KIF28P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)8.11580656
2thrombin receptor signaling pathway (GO:0070493)7.45893389
3neutrophil activation involved in immune response (GO:0002283)6.90497660
4blood coagulation, intrinsic pathway (GO:0007597)5.93089208
5regulation of platelet aggregation (GO:0090330)5.85888447
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.84917532
7adenosine receptor signaling pathway (GO:0001973)5.52637506
8regulation of platelet activation (GO:0010543)5.49597663
9negative regulation of norepinephrine secretion (GO:0010700)5.29705137
10G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.07332921
11platelet aggregation (GO:0070527)4.99530862
12leukocyte migration involved in inflammatory response (GO:0002523)4.97666205
13regulation of integrin-mediated signaling pathway (GO:2001044)4.94805236
14low-density lipoprotein particle remodeling (GO:0034374)4.77940310
15negative regulation of platelet activation (GO:0010544)4.70886863
16negative regulation of homotypic cell-cell adhesion (GO:0034111)4.63447766
17purinergic nucleotide receptor signaling pathway (GO:0035590)4.60310456
18negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.58357470
19negative regulation of thymocyte apoptotic process (GO:0070244)4.47534487
20positive regulation of endothelial cell differentiation (GO:0045603)4.36823281
21regulation of lipoprotein metabolic process (GO:0050746)4.25808345
22negative regulation of heart rate (GO:0010459)4.24016257
23angiogenesis involved in wound healing (GO:0060055)4.13662324
24positive regulation of mast cell activation (GO:0033005)3.95774506
25negative regulation of protein localization to cell surface (GO:2000009)3.95138735
26fusion of sperm to egg plasma membrane (GO:0007342)3.94886014
27neutrophil activation (GO:0042119)3.92418002
28negative regulation of response to food (GO:0032096)3.92154643
29negative regulation of appetite (GO:0032099)3.92154643
30regulation of Golgi to plasma membrane protein transport (GO:0042996)3.89618041
31lipoxygenase pathway (GO:0019372)3.88063063
32platelet degranulation (GO:0002576)3.87703821
33megakaryocyte development (GO:0035855)3.84277664
34purinergic receptor signaling pathway (GO:0035587)3.79318906
35high-density lipoprotein particle remodeling (GO:0034375)3.77818815
36G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.68212171
37regulation of integrin activation (GO:0033623)3.66351798
38beta-amyloid metabolic process (GO:0050435)3.65380657
39regulation of norepinephrine secretion (GO:0014061)3.61815394
40platelet activation (GO:0030168)3.59517484
41polyamine biosynthetic process (GO:0006596)3.58681222
42positive regulation of cAMP-mediated signaling (GO:0043950)3.57836110
43platelet formation (GO:0030220)3.56063597
44reverse cholesterol transport (GO:0043691)3.54019761
45positive regulation of macrophage differentiation (GO:0045651)3.53878953
46positive regulation of blood coagulation (GO:0030194)3.53137773
47positive regulation of hemostasis (GO:1900048)3.53137773
48positive regulation of systemic arterial blood pressure (GO:0003084)3.52994733
49regulation of MHC class II biosynthetic process (GO:0045346)3.52315613
50positive regulation of granulocyte differentiation (GO:0030854)3.44918268
51positive regulation of Rho protein signal transduction (GO:0035025)3.43622668
52regulation of macrophage derived foam cell differentiation (GO:0010743)3.40277324
53negative regulation of T-helper cell differentiation (GO:0045623)3.40052518
54negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.40052518
55relaxation of smooth muscle (GO:0044557)3.37583431
56granulocyte activation (GO:0036230)3.36035079
57erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.35822234
58L-phenylalanine catabolic process (GO:0006559)3.35822234
59homotypic cell-cell adhesion (GO:0034109)3.35577533
60regulation of female receptivity (GO:0045924)3.29673626
61negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.29590496
62negative regulation of catecholamine secretion (GO:0033604)3.29356047
63regulation of homotypic cell-cell adhesion (GO:0034110)3.28248899
64negative regulation of neural precursor cell proliferation (GO:2000178)3.26409766
65termination of G-protein coupled receptor signaling pathway (GO:0038032)3.23728793
66phospholipid homeostasis (GO:0055091)3.20278325
67autophagic vacuole fusion (GO:0000046)3.16271388
68positive regulation of receptor recycling (GO:0001921)3.12774545
69negative regulation of heart contraction (GO:0045822)3.12441721
70positive regulation of coagulation (GO:0050820)3.09559466
71termination of signal transduction (GO:0023021)3.08755436
72leukocyte degranulation (GO:0043299)3.06421163
73regulation of hemostasis (GO:1900046)3.05906971
74regulation of blood coagulation (GO:0030193)3.05906971
75negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.04168142
76negative regulation of T cell apoptotic process (GO:0070233)3.01456897
77positive regulation of protein homodimerization activity (GO:0090073)3.01197841
78positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.98605080
79negative regulation of interleukin-17 production (GO:0032700)2.94096885
80regulation of memory T cell differentiation (GO:0043380)2.93559068
81extracellular fibril organization (GO:0043206)2.92164463
82endothelium development (GO:0003158)2.90902666
83regulation of endothelial cell differentiation (GO:0045601)2.89270319
84negative regulation of blood coagulation (GO:0030195)2.88782543
85negative regulation of hemostasis (GO:1900047)2.88782543
86female mating behavior (GO:0060180)2.86910549
87positive regulation of muscle hypertrophy (GO:0014742)2.86691534
88positive regulation of cardiac muscle hypertrophy (GO:0010613)2.86691534
89plasma membrane fusion (GO:0045026)2.86071701
90regulation of T-helper 1 cell differentiation (GO:0045625)2.83263813
91tyrosine metabolic process (GO:0006570)2.82229164
92fatty acid elongation (GO:0030497)2.81574741
93regulation of mast cell activation (GO:0033003)2.81277590
94pyrimidine nucleoside catabolic process (GO:0046135)2.79310946
95regulation of coagulation (GO:0050818)2.74879714
96monoamine transport (GO:0015844)2.74591734
97regulation of megakaryocyte differentiation (GO:0045652)2.71270765
98regulation of cholesterol efflux (GO:0010874)2.70757255
99negative regulation of calcium ion transport into cytosol (GO:0010523)2.70528988
100phagocytosis, engulfment (GO:0006911)2.69087416

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.65992314
2SCL_19346495_ChIP-Seq_HPC-7_Human3.95348091
3LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.84740864
4EZH2_22144423_ChIP-Seq_EOC_Human3.24631156
5GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.02958505
6GBX2_23144817_ChIP-Seq_PC3_Human2.91008452
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.59929977
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.59913101
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.59261932
10GATA1_19941826_ChIP-Seq_K562_Human2.52080279
11LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.47419577
12GATA2_19941826_ChIP-Seq_K562_Human2.27782423
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.25614082
14GATA1_19941827_ChIP-Seq_MEL_Mouse2.23038432
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.22785192
16GATA2_21666600_ChIP-Seq_HMVEC_Human2.14518839
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13918518
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.13159693
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.09003162
20SPI1_23127762_ChIP-Seq_K562_Human2.05258876
21IKZF1_21737484_ChIP-ChIP_HCT116_Human1.87361753
22IRF8_21731497_ChIP-ChIP_J774_Mouse1.83165806
23IGF1R_20145208_ChIP-Seq_DFB_Human1.77543183
24GATA1_22025678_ChIP-Seq_K562_Human1.76498357
25GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.75144896
26HTT_18923047_ChIP-ChIP_STHdh_Human1.74748249
27TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.73822145
28ELK4_26923725_Chip-Seq_MESODERM_Mouse1.69050861
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.65788031
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64413047
31TAF15_26573619_Chip-Seq_HEK293_Human1.63522144
32GATA1_22383799_ChIP-Seq_G1ME_Mouse1.61315590
33SRY_22984422_ChIP-ChIP_TESTIS_Rat1.54818426
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54005401
35PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43104161
36GATA1_19941827_ChIP-Seq_MEL86_Mouse1.38153130
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36984410
38NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35562216
39NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35562216
40RUNX_20019798_ChIP-Seq_JUKART_Human1.32554465
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.31470094
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31054753
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.29223397
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.28636181
45VDR_22108803_ChIP-Seq_LS180_Human1.28459965
46STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.26476442
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24578446
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22022325
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.20557615
50SMAD4_21799915_ChIP-Seq_A2780_Human1.20438672
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18592946
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16465073
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14937828
54BCAT_22108803_ChIP-Seq_LS180_Human1.14576275
55TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13398367
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10772106
57EWS_26573619_Chip-Seq_HEK293_Human1.09973031
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07727239
59ER_23166858_ChIP-Seq_MCF-7_Human1.06847581
60AR_25329375_ChIP-Seq_VCAP_Human1.05153346
61TCF4_18268006_ChIP-ChIP_LS174T_Human1.04865400
62SALL4_22934838_ChIP-ChIP_CD34+_Human1.04797077
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02915276
64OCT1_27270436_Chip-Seq_PROSTATE_Human1.01943859
65KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.01554261
66PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.01090331
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99827016
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97362375
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96519554
70LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96278997
71PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93861368
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93606450
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93512089
74EZH2_27294783_Chip-Seq_NPCs_Mouse0.93229582
75SPI1_20517297_ChIP-Seq_HL60_Human0.92463747
76P300_19829295_ChIP-Seq_ESCs_Human0.91686387
77GATA3_21878914_ChIP-Seq_MCF-7_Human0.90464814
78ETS1_22383799_ChIP-Seq_G1ME_Mouse0.90372121
79STAT3_23295773_ChIP-Seq_U87_Human0.89882695
80PIAS1_25552417_ChIP-Seq_VCAP_Human0.89646859
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88262079
82GATA3_27048872_Chip-Seq_THYMUS_Human0.86980874
83IRF8_22096565_ChIP-ChIP_GC-B_Human0.86819096
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86484995
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86459092
86NANOG_19829295_ChIP-Seq_ESCs_Human0.83709977
87SOX2_19829295_ChIP-Seq_ESCs_Human0.83709977
88ARNT_22903824_ChIP-Seq_MCF-7_Human0.83319406
89TCF4_23295773_ChIP-Seq_U87_Human0.82755125
90P53_22387025_ChIP-Seq_ESCs_Mouse0.81532991
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.80016992
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80016992
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79160263
94SMRT_27268052_Chip-Seq_Bcells_Human0.78880794
95IRF1_19129219_ChIP-ChIP_H3396_Human0.78744875
96FLI1_27457419_Chip-Seq_LIVER_Mouse0.78699689
97TBL1_22424771_ChIP-Seq_293T_Human0.78075560
98LXR_22158963_ChIP-Seq_LIVER_Mouse0.77929262
99STAT1_20625510_ChIP-Seq_HELA_Human0.77449743
100CEBPB_22108803_ChIP-Seq_LS180_Human0.77265762

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology9.65948089
2MP0008004_abnormal_stomach_pH5.74006490
3MP0003724_increased_susceptibility_to3.43042797
4MP0000465_gastrointestinal_hemorrhage3.32450078
5MP0004084_abnormal_cardiac_muscle2.53391795
6MP0004510_myositis2.45058189
7MP0005084_abnormal_gallbladder_morpholo2.32518150
8MP0000230_abnormal_systemic_arterial2.22734035
9MP0001835_abnormal_antigen_presentation2.20257826
10MP0000343_altered_response_to2.17046669
11MP0005410_abnormal_fertilization2.09068572
12MP0002736_abnormal_nociception_after2.07556970
13MP0005083_abnormal_biliary_tract1.97103080
14MP0005646_abnormal_pituitary_gland1.87983360
15MP0002132_abnormal_respiratory_system1.85451720
16MP0008872_abnormal_physiological_respon1.81436752
17MP0004036_abnormal_muscle_relaxation1.80513567
18MP0008775_abnormal_heart_ventricle1.78875198
19MP0005058_abnormal_lysosome_morphology1.78863434
20MP0003303_peritoneal_inflammation1.75627332
21MP0001879_abnormal_lymphatic_vessel1.69356069
22MP0001545_abnormal_hematopoietic_system1.69141482
23MP0005397_hematopoietic_system_phenotyp1.69141482
24MP0003638_abnormal_response/metabolism_1.67301347
25MP0001968_abnormal_touch/_nociception1.64941005
26MP0003879_abnormal_hair_cell1.61197807
27MP0003828_pulmonary_edema1.59785442
28MP0004130_abnormal_muscle_cell1.58668889
29MP0005167_abnormal_blood-brain_barrier1.53352784
30MP0010329_abnormal_lipoprotein_level1.52037838
31MP0010155_abnormal_intestine_physiology1.50865907
32MP0003566_abnormal_cell_adhesion1.46315772
33MP0009697_abnormal_copulation1.39092297
34MP0002148_abnormal_hypersensitivity_rea1.39066043
35MP0003136_yellow_coat_color1.35975416
36MP0002733_abnormal_thermal_nociception1.35441766
37MP0001851_eye_inflammation1.30984434
38MP0002398_abnormal_bone_marrow1.30505067
39MP0006276_abnormal_autonomic_nervous1.29902256
40MP0000249_abnormal_blood_vessel1.29540243
41MP0009780_abnormal_chondrocyte_physiolo1.25554367
42MP0005000_abnormal_immune_tolerance1.24294417
43MP0005671_abnormal_response_to1.20628875
44MP0001663_abnormal_digestive_system1.18233727
45MP0003656_abnormal_erythrocyte_physiolo1.08455303
46MP0004215_abnormal_myocardial_fiber1.07944340
47MP0001664_abnormal_digestion1.07209148
48MP0010368_abnormal_lymphatic_system1.06280195
49MP0009763_increased_sensitivity_to1.05450386
50MP0009642_abnormal_blood_homeostasis1.01950422
51MP0010386_abnormal_urinary_bladder0.99234819
52MP0009278_abnormal_bone_marrow0.96850543
53MP0001970_abnormal_pain_threshold0.95867396
54MP0000689_abnormal_spleen_morphology0.95829708
55MP0002723_abnormal_immune_serum0.95289378
56MP0000858_altered_metastatic_potential0.93654638
57MP0004484_altered_response_of0.93483278
58MP0008874_decreased_physiological_sensi0.93396200
59MP0003183_abnormal_peptide_metabolism0.93394960
60MP0003436_decreased_susceptibility_to0.93141410
61MP0005409_darkened_coat_color0.93041526
62MP0004808_abnormal_hematopoietic_stem0.90504307
63MP0002429_abnormal_blood_cell0.88488175
64MP0001533_abnormal_skeleton_physiology0.87939398
65MP0005666_abnormal_adipose_tissue0.87173751
66MP0004134_abnormal_chest_morphology0.87117881
67MP0001800_abnormal_humoral_immune0.85172707
68MP0005174_abnormal_tail_pigmentation0.84993043
69MP0002735_abnormal_chemical_nociception0.83416194
70MP0000015_abnormal_ear_pigmentation0.83388775
71MP0002722_abnormal_immune_system0.82893456
72MP0004947_skin_inflammation0.79450696
73MP0002452_abnormal_antigen_presenting0.79192669
74MP0002972_abnormal_cardiac_muscle0.78810583
75MP0005385_cardiovascular_system_phenoty0.78484780
76MP0001544_abnormal_cardiovascular_syste0.78484780
77MP0009764_decreased_sensitivity_to0.77444092
78MP0009765_abnormal_xenobiotic_induced0.76849576
79MP0002118_abnormal_lipid_homeostasis0.76454064
80MP0006138_congestive_heart_failure0.76007617
81MP0001765_abnormal_ion_homeostasis0.75855334
82MP0005535_abnormal_body_temperature0.75814087
83MP0000716_abnormal_immune_system0.75468902
84MP0006036_abnormal_mitochondrial_physio0.75408294
85MP0002420_abnormal_adaptive_immunity0.75350168
86MP0005381_digestive/alimentary_phenotyp0.75142957
87MP0002419_abnormal_innate_immunity0.74628487
88MP0002128_abnormal_blood_circulation0.73703452
89MP0001819_abnormal_immune_cell0.73511383
90MP0003866_abnormal_defecation0.73066610
91MP0005365_abnormal_bile_salt0.71208181
92MP0001756_abnormal_urination0.70781444
93MP0000685_abnormal_immune_system0.70478096
94MP0001845_abnormal_inflammatory_respons0.70219483
95MP0005620_abnormal_muscle_contractility0.70092142
96MP0002876_abnormal_thyroid_physiology0.70049763
97MP0004085_abnormal_heartbeat0.69641151
98MP0005025_abnormal_response_to0.68309864
99MP0002998_abnormal_bone_remodeling0.65684573
100MP0006054_spinal_hemorrhage0.64025872

Predicted human phenotypes

RankGene SetZ-score
1Abnormal platelet volume (HP:0011876)9.45402110
2Petechiae (HP:0000967)9.27189186
3Purpura (HP:0000979)8.71912166
4Epistaxis (HP:0000421)7.95145366
5Gingival bleeding (HP:0000225)6.79758250
6Hyperlipoproteinemia (HP:0010980)6.18422055
7Abnormal platelet function (HP:0011869)5.83253015
8Impaired platelet aggregation (HP:0003540)5.83253015
9Dyschromatopsia (HP:0007641)4.77374073
10Spontaneous hematomas (HP:0007420)4.40266589
11Poikilocytosis (HP:0004447)4.23224714
12Acanthocytosis (HP:0001927)4.16226472
13Abnormality of the common coagulation pathway (HP:0010990)3.92541303
14Abnormality of lateral ventricle (HP:0030047)3.60209258
15Bruising susceptibility (HP:0000978)3.51031255
16Conjunctival telangiectasia (HP:0000524)3.47883300
17Abnormal pupillary function (HP:0007686)3.42607503
18Joint hemorrhage (HP:0005261)3.15670005
19Abnormality of the vasculature of the conjunctiva (HP:0008054)2.98190701
20Decreased central vision (HP:0007663)2.87922421
21Paralysis (HP:0003470)2.85901089
22Abnormality of the heme biosynthetic pathway (HP:0010472)2.85426824
23Thyroid-stimulating hormone excess (HP:0002925)2.79269408
24Increased density of long bones (HP:0006392)2.75246908
25Xanthomatosis (HP:0000991)2.68879701
26Joint swelling (HP:0001386)2.55819638
27Spontaneous abortion (HP:0005268)2.51452652
28Abnormal auditory evoked potentials (HP:0006958)2.38345424
29Hepatosplenomegaly (HP:0001433)2.22547935
30Abnormal ciliary motility (HP:0012262)2.20102222
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.18829609
32Ventricular fibrillation (HP:0001663)2.12899276
33Abnormality of iron homeostasis (HP:0011031)2.11656038
34Hypophosphatemic rickets (HP:0004912)2.10829499
35Generalized aminoaciduria (HP:0002909)2.06331669
36Prolonged bleeding time (HP:0003010)11.7564341
37Menorrhagia (HP:0000132)10.6363366
38Increased mean platelet volume (HP:0011877)10.0310088
39Papillary thyroid carcinoma (HP:0002895)1.96494122
40Encephalitis (HP:0002383)1.94319622
41Biliary tract neoplasm (HP:0100574)1.92986889
42Stomatitis (HP:0010280)1.90504494
43Absent/shortened dynein arms (HP:0200106)1.89669133
44Dynein arm defect of respiratory motile cilia (HP:0012255)1.89669133
45Thrombocytosis (HP:0001894)1.89044783
46Abnormality of transition element cation homeostasis (HP:0011030)1.88433345
47Tinnitus (HP:0000360)1.88320418
48Episodic fever (HP:0001954)1.86593351
49Abnormality of the prostate (HP:0008775)1.86355125
50Upper limb muscle weakness (HP:0003484)1.85270994
51Panhypogammaglobulinemia (HP:0003139)1.84059225
52Male infertility (HP:0003251)1.83775905
53Hyperthyroidism (HP:0000836)1.81391036
54Abnormality of macrophages (HP:0004311)1.81051067
55Increased IgM level (HP:0003496)1.79532440
56Central scotoma (HP:0000603)1.78305701
57Arterial thrombosis (HP:0004420)1.75800003
58Nausea (HP:0002018)1.72388454
59Abnormal respiratory epithelium morphology (HP:0012253)1.69687135
60Abnormal respiratory motile cilium morphology (HP:0005938)1.69687135
61Mitral stenosis (HP:0001718)1.67506233
62Polyphagia (HP:0002591)1.64967049
63Febrile seizures (HP:0002373)1.64902686
64Infertility (HP:0000789)1.63778605
65Arthropathy (HP:0003040)1.63041172
66Tongue fasciculations (HP:0001308)1.60355824
67Increased serum ferritin (HP:0003281)1.59034846
68Autoimmune hemolytic anemia (HP:0001890)1.57489824
69Chronic obstructive pulmonary disease (HP:0006510)1.56214674
70Obstructive lung disease (HP:0006536)1.56214674
71Testicular neoplasm (HP:0010788)1.54439406
72Polycythemia (HP:0001901)1.53653893
73Eosinophilia (HP:0001880)1.52225076
74Inflammation of the large intestine (HP:0002037)1.49660280
75Basal ganglia calcification (HP:0002135)1.49101614
76Muscle fiber splitting (HP:0003555)1.49067143
77Renal cortical cysts (HP:0000803)1.48962836
78Thrombophlebitis (HP:0004418)1.47948757
79Dysautonomia (HP:0002459)1.46763094
80Granulocytopenia (HP:0001913)1.43935573
81Diplopia (HP:0000651)1.43890822
82Abnormality of binocular vision (HP:0011514)1.43890822
83Muscle fibrillation (HP:0010546)1.43167992
84Visual hallucinations (HP:0002367)1.42569742
85Myocardial infarction (HP:0001658)1.41755855
863-Methylglutaconic aciduria (HP:0003535)1.40840774
87Vertigo (HP:0002321)1.40322044
88Congenital sensorineural hearing impairment (HP:0008527)1.39877442
89Transitional cell carcinoma of the bladder (HP:0006740)1.39715486
90Abnormal respiratory motile cilium physiology (HP:0012261)1.38948903
91Gonadal dysgenesis (HP:0000133)1.38238251
92Chest pain (HP:0100749)1.36691328
93Gastrointestinal inflammation (HP:0004386)1.35670980
94Aortic aneurysm (HP:0004942)1.31843237
95Acute lymphatic leukemia (HP:0006721)1.31399786
96Clumsiness (HP:0002312)1.30894888
97Leiomyosarcoma (HP:0100243)1.29688824
98Uterine leiomyosarcoma (HP:0002891)1.29688824
99Hypomagnesemia (HP:0002917)1.28015643
100Leukocytosis (HP:0001974)1.25856952

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.59082147
2MYLK4.01754189
3MST44.00047666
4BMX3.86810135
5TEC3.19146857
6BTK3.08329389
7PTK2B2.72300774
8TAOK32.50540092
9CSF1R2.44298128
10SYK2.32146494
11EIF2AK12.31949864
12PIK3CG2.31045436
13ZAP701.88985317
14GRK61.87812133
15GRK51.86199400
16ILK1.81180048
17STK31.80574957
18ADRBK21.69803580
19MAPKAPK31.64385006
20FES1.63145192
21TNK21.58930522
22MARK31.57697477
23BMPR21.56081098
24FGR1.47513857
25HCK1.47161670
26PNCK1.34665376
27PLK21.31096141
28BMPR1B1.24561245
29TNIK1.18293704
30LYN1.06787321
31DAPK31.06364929
32PINK11.06359512
33PAK11.05365925
34NUAK11.04775686
35MAP3K50.99287371
36FLT30.99225016
37MAP2K30.98801605
38IKBKB0.98416895
39FRK0.95804215
40TRIM280.93638482
41DAPK20.92860393
42RET0.92646818
43BLK0.87580183
44MAPK120.87141913
45MAP4K20.86183313
46PDK10.83625330
47LMTK20.82975993
48ACVR1B0.80448415
49ITK0.79523694
50SGK20.77959880
51ADRBK10.76540605
52PKN10.75511471
53PRKD10.75467307
54MATK0.73343150
55IRAK10.71255913
56SIK30.70883372
57EPHA30.69508693
58MAPK130.69144777
59STK240.67019979
60PDPK10.66427344
61FER0.64657480
62TLK10.63685310
63NLK0.63451707
64GRK10.61403218
65CDK80.60864261
66PRKG10.60669701
67PRKCQ0.59872399
68KIT0.55893292
69PIM20.55671831
70PRKACG0.55465516
71INSRR0.54533785
72ERBB20.54491782
73TAOK20.51683663
74TXK0.48485880
75MINK10.46146053
76PDGFRB0.45442816
77LCK0.43982429
78PAK30.41116814
79DAPK10.39440015
80TAOK10.38968150
81CDK30.38076173
82PKN20.37595970
83MAP2K10.37446290
84STK40.36826330
85OBSCN0.35751816
86SGK4940.34671028
87SGK2230.34671028
88MAP3K30.34622431
89SGK30.34531055
90IGF1R0.34395287
91HIPK20.33574924
92ROCK10.33503077
93PRKCB0.33311957
94DYRK1A0.29585393
95FYN0.29403005
96CAMK10.28627141
97PRKCA0.28287439
98PRKCE0.27608819
99PAK20.26532875
100JAK20.24964609

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046115.55990561
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.34106494
3SNARE interactions in vesicular transport_Homo sapiens_hsa041302.90641617
4Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.75634760
5Nitrogen metabolism_Homo sapiens_hsa009102.43565212
6Arachidonic acid metabolism_Homo sapiens_hsa005902.16843566
7ECM-receptor interaction_Homo sapiens_hsa045122.07702766
8Hematopoietic cell lineage_Homo sapiens_hsa046402.06775560
9Gap junction_Homo sapiens_hsa045402.02262468
10Vascular smooth muscle contraction_Homo sapiens_hsa042701.95788880
11Serotonergic synapse_Homo sapiens_hsa047261.76430115
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.63889257
13Chemokine signaling pathway_Homo sapiens_hsa040621.61819370
14Olfactory transduction_Homo sapiens_hsa047401.49566240
15Alcoholism_Homo sapiens_hsa050341.48053729
16Systemic lupus erythematosus_Homo sapiens_hsa053221.44100816
17Linoleic acid metabolism_Homo sapiens_hsa005911.37827449
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36590356
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.34055258
20Glycerolipid metabolism_Homo sapiens_hsa005611.31200221
21Pancreatic secretion_Homo sapiens_hsa049721.25592064
22B cell receptor signaling pathway_Homo sapiens_hsa046621.23283176
23Circadian entrainment_Homo sapiens_hsa047131.22934111
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.19925773
25Collecting duct acid secretion_Homo sapiens_hsa049661.17523469
26Long-term depression_Homo sapiens_hsa047301.11051824
27Chemical carcinogenesis_Homo sapiens_hsa052041.06135095
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03498596
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03141718
30Phospholipase D signaling pathway_Homo sapiens_hsa040721.03063611
31Complement and coagulation cascades_Homo sapiens_hsa046101.00072973
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98489576
33Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97404895
34Endocytosis_Homo sapiens_hsa041440.95590286
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93296470
36Starch and sucrose metabolism_Homo sapiens_hsa005000.89040195
37Calcium signaling pathway_Homo sapiens_hsa040200.87988813
38Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84855310
39Choline metabolism in cancer_Homo sapiens_hsa052310.82369990
40Glycerophospholipid metabolism_Homo sapiens_hsa005640.81316745
41Leukocyte transendothelial migration_Homo sapiens_hsa046700.81051786
42Renin secretion_Homo sapiens_hsa049240.79944053
43Morphine addiction_Homo sapiens_hsa050320.79694334
44Glutathione metabolism_Homo sapiens_hsa004800.78340106
45Fatty acid elongation_Homo sapiens_hsa000620.77883084
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76902568
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76654819
48Focal adhesion_Homo sapiens_hsa045100.75927435
49Phototransduction_Homo sapiens_hsa047440.74022388
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73298837
51Sulfur metabolism_Homo sapiens_hsa009200.73148256
52Malaria_Homo sapiens_hsa051440.72376745
53GABAergic synapse_Homo sapiens_hsa047270.70956412
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70919742
55Shigellosis_Homo sapiens_hsa051310.69869566
56T cell receptor signaling pathway_Homo sapiens_hsa046600.69691915
57Oxytocin signaling pathway_Homo sapiens_hsa049210.68325334
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66498702
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66362789
60ABC transporters_Homo sapiens_hsa020100.66244936
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66026946
62Rap1 signaling pathway_Homo sapiens_hsa040150.64771677
63Fat digestion and absorption_Homo sapiens_hsa049750.63518715
64Dilated cardiomyopathy_Homo sapiens_hsa054140.63235288
65Staphylococcus aureus infection_Homo sapiens_hsa051500.63203504
66Regulation of autophagy_Homo sapiens_hsa041400.62931332
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62204814
68Retinol metabolism_Homo sapiens_hsa008300.61976155
69beta-Alanine metabolism_Homo sapiens_hsa004100.60481852
70Ras signaling pathway_Homo sapiens_hsa040140.60448397
71Cholinergic synapse_Homo sapiens_hsa047250.59728679
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58003102
73Phagosome_Homo sapiens_hsa041450.57688258
74Glutamatergic synapse_Homo sapiens_hsa047240.57636498
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57510584
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57461741
77Gastric acid secretion_Homo sapiens_hsa049710.57183177
78Sphingolipid metabolism_Homo sapiens_hsa006000.54638675
79Primary immunodeficiency_Homo sapiens_hsa053400.52861467
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51982318
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51243936
82Melanoma_Homo sapiens_hsa052180.51169016
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50930863
84PPAR signaling pathway_Homo sapiens_hsa033200.50843591
85Endometrial cancer_Homo sapiens_hsa052130.50677171
86Non-small cell lung cancer_Homo sapiens_hsa052230.49919184
87Pancreatic cancer_Homo sapiens_hsa052120.46241012
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.44952484
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44506424
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41611005
91Osteoclast differentiation_Homo sapiens_hsa043800.40113706
92Glioma_Homo sapiens_hsa052140.39276368
93Salivary secretion_Homo sapiens_hsa049700.38828229
94Ovarian steroidogenesis_Homo sapiens_hsa049130.37744211
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35899111
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.35691273
97Bile secretion_Homo sapiens_hsa049760.35448259
98Renin-angiotensin system_Homo sapiens_hsa046140.34941243
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33349602
100Viral carcinogenesis_Homo sapiens_hsa052030.33099788

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