KIF2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)6.16026275
2protein neddylation (GO:0045116)5.93180516
3regulation of histone H3-K9 methylation (GO:0051570)4.35922440
4regulation of MHC class II biosynthetic process (GO:0045346)4.32766728
5neuron cell-cell adhesion (GO:0007158)4.29269155
6positive regulation of granulocyte differentiation (GO:0030854)4.23718190
7regulation of platelet aggregation (GO:0090330)4.14390930
8nuclear pore organization (GO:0006999)3.95593484
9vocalization behavior (GO:0071625)3.88052525
10neutrophil activation involved in immune response (GO:0002283)3.82036199
11presynaptic membrane assembly (GO:0097105)3.80503374
12negative regulation of histone methylation (GO:0031061)3.78770460
13platelet aggregation (GO:0070527)3.72642634
14regulation of Golgi to plasma membrane protein transport (GO:0042996)3.70895935
15negative regulation of dendrite morphogenesis (GO:0050774)3.69810424
16negative regulation of norepinephrine secretion (GO:0010700)3.67002677
17megakaryocyte development (GO:0035855)3.64790684
18G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.61730648
19negative regulation of thymocyte apoptotic process (GO:0070244)3.56466988
20protein localization to synapse (GO:0035418)3.55950983
21pore complex assembly (GO:0046931)3.52147619
22regulation of platelet activation (GO:0010543)3.47268034
23postsynaptic membrane organization (GO:0001941)3.46016557
24synaptic vesicle exocytosis (GO:0016079)3.44618907
25regulation of synaptic vesicle exocytosis (GO:2000300)3.41775764
26regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.40095788
27glutamate secretion (GO:0014047)3.38705537
28DNA double-strand break processing (GO:0000729)3.36298285
29regulation of short-term neuronal synaptic plasticity (GO:0048172)3.33053779
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.30088257
31centriole replication (GO:0007099)3.29408036
32positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.28179260
33presynaptic membrane organization (GO:0097090)3.28083089
34phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.27433647
35blood coagulation, intrinsic pathway (GO:0007597)3.26608388
36negative regulation of heart rate (GO:0010459)3.26536486
37leukocyte migration involved in inflammatory response (GO:0002523)3.09112713
38platelet formation (GO:0030220)3.06895520
39negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.06497705
40synaptic vesicle docking involved in exocytosis (GO:0016081)3.04528757
41regulation of glutamate receptor signaling pathway (GO:1900449)3.04396183
42mitotic sister chromatid cohesion (GO:0007064)3.04357451
43long-chain fatty acid biosynthetic process (GO:0042759)3.00554926
44regulation of integrin activation (GO:0033623)3.00198326
45startle response (GO:0001964)2.99027906
46inositol phosphate catabolic process (GO:0071545)2.97525591
47purinergic nucleotide receptor signaling pathway (GO:0035590)2.96130682
48negative regulation of DNA recombination (GO:0045910)2.94581320
49positive regulation of endothelial cell differentiation (GO:0045603)2.94474395
50regulation of synaptic vesicle transport (GO:1902803)2.94135714
51negative regulation of dendrite development (GO:2000171)2.93425908
52ionotropic glutamate receptor signaling pathway (GO:0035235)2.89890420
53cell migration in hindbrain (GO:0021535)2.88842704
54negative regulation of synaptic transmission, GABAergic (GO:0032229)2.86815381
55positive regulation of mast cell activation (GO:0033005)2.86674705
56DNA topological change (GO:0006265)2.84680346
57serotonin receptor signaling pathway (GO:0007210)2.84141360
58negative regulation of fibroblast apoptotic process (GO:2000270)2.83738603
59synaptic vesicle maturation (GO:0016188)2.82004690
60CENP-A containing nucleosome assembly (GO:0034080)2.80725438
61angiogenesis involved in wound healing (GO:0060055)2.80566055
62synaptic vesicle endocytosis (GO:0048488)2.80449253
63adenosine receptor signaling pathway (GO:0001973)2.80422067
64regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.80096515
65regulation of centriole replication (GO:0046599)2.77776315
66piRNA metabolic process (GO:0034587)2.77585658
67chromatin remodeling at centromere (GO:0031055)2.76734945
68definitive hemopoiesis (GO:0060216)2.76577057
69neurotransmitter-gated ion channel clustering (GO:0072578)2.75499045
70regulation of megakaryocyte differentiation (GO:0045652)2.74744433
71dendrite development (GO:0016358)2.74666927
72meiotic chromosome segregation (GO:0045132)2.73755743
73neuron-neuron synaptic transmission (GO:0007270)2.72719405
74homotypic cell-cell adhesion (GO:0034109)2.72709777
75hepatocyte apoptotic process (GO:0097284)2.70865623
76protein localization to microtubule cytoskeleton (GO:0072698)2.70046287
77negative regulation of heart contraction (GO:0045822)2.69764662
78regulation of B cell receptor signaling pathway (GO:0050855)2.69536883
79positive regulation of alpha-beta T cell proliferation (GO:0046641)2.69439511
80kinetochore organization (GO:0051383)2.69192752
81monoubiquitinated protein deubiquitination (GO:0035520)2.68862045
82synaptic transmission, glutamatergic (GO:0035249)2.68453610
83DNA replication-independent nucleosome organization (GO:0034724)2.68142006
84DNA replication-independent nucleosome assembly (GO:0006336)2.68142006
85cerebral cortex radially oriented cell migration (GO:0021799)2.66458865
86glutamate receptor signaling pathway (GO:0007215)2.66176435
87DNA synthesis involved in DNA repair (GO:0000731)2.65100659
88positive regulation of B cell differentiation (GO:0045579)2.64927740
89DNA unwinding involved in DNA replication (GO:0006268)2.64102932
90neuron recognition (GO:0008038)2.63785120
91positive regulation of macrophage differentiation (GO:0045651)2.61328900
92protein localization to kinetochore (GO:0034501)2.61044652
93pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.59836864
94acrosome assembly (GO:0001675)2.59444351
95regulation of DNA endoreduplication (GO:0032875)2.59145669
96neurotransmitter secretion (GO:0007269)2.57620365
97positive regulation of cAMP-mediated signaling (GO:0043950)2.57257467
98positive regulation of synapse assembly (GO:0051965)2.56728971
99regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.56686662
100positive regulation of histone methylation (GO:0031062)2.56478295
101cilium or flagellum-dependent cell motility (GO:0001539)2.56225674
102nerve growth factor signaling pathway (GO:0038180)2.56183468
103mRNA splice site selection (GO:0006376)2.53444916
104protein localization to microtubule (GO:0035372)2.53024689
105regulation of histone H3-K4 methylation (GO:0051569)2.52747559
106sister chromatid segregation (GO:0000819)2.52152667
107regulation of response to tumor cell (GO:0002834)2.51468237
108positive regulation of response to tumor cell (GO:0002836)2.51468237
109positive regulation of immune response to tumor cell (GO:0002839)2.51468237
110regulation of immune response to tumor cell (GO:0002837)2.51468237
111neuronal action potential propagation (GO:0019227)2.51428382
112negative regulation of neurotransmitter secretion (GO:0046929)2.51247893
113double-strand break repair via nonhomologous end joining (GO:0006303)2.50787852
114non-recombinational repair (GO:0000726)2.50787852
115mitotic G2/M transition checkpoint (GO:0044818)2.49833641
116positive regulation of gamma-delta T cell activation (GO:0046645)2.49642662
117polyamine biosynthetic process (GO:0006596)2.49504398
118regulation of erythrocyte differentiation (GO:0045646)2.48339026
119negative regulation of catecholamine secretion (GO:0033604)2.47926691
120regulation of excitatory postsynaptic membrane potential (GO:0060079)2.47454218
121positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.46681620
122regulation of long-term neuronal synaptic plasticity (GO:0048169)2.46453878
123epithelial cilium movement (GO:0003351)2.45441450
124acrosome reaction (GO:0007340)2.45263286
125histone mRNA catabolic process (GO:0071044)2.44910865
126central nervous system projection neuron axonogenesis (GO:0021952)2.44675027
127negative regulation of response to food (GO:0032096)2.44074993
128negative regulation of appetite (GO:0032099)2.44074993
129regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.43860793
130cerebellar Purkinje cell differentiation (GO:0021702)2.43667164
131mitotic recombination (GO:0006312)2.43520194
132positive regulation of cardiac muscle hypertrophy (GO:0010613)2.43201624
133positive regulation of muscle hypertrophy (GO:0014742)2.43201624
134histone exchange (GO:0043486)2.42097183
135V(D)J recombination (GO:0033151)2.42088267
136negative regulation of neurotransmitter transport (GO:0051589)2.42038334
137innervation (GO:0060384)2.41867316
138replication fork processing (GO:0031297)2.41479372
139negative regulation of T cell apoptotic process (GO:0070233)2.41438035
140spindle assembly (GO:0051225)2.40950179
141regulation of synapse assembly (GO:0051963)2.40565222
142regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.40542259
143calcium ion-dependent exocytosis (GO:0017156)2.40319380
144mismatch repair (GO:0006298)2.39889974
145negative regulation of DNA-dependent DNA replication (GO:2000104)2.39834734
146hippocampus development (GO:0021766)2.38025023
147axonal fasciculation (GO:0007413)2.37823501
148protein localization to cytoskeleton (GO:0044380)2.37064016
149regulation of postsynaptic membrane potential (GO:0060078)2.36985283
150long-term synaptic potentiation (GO:0060291)2.36493045
151regulation of clathrin-mediated endocytosis (GO:2000369)2.36168649
152spindle checkpoint (GO:0031577)2.35383469
153telomere maintenance via semi-conservative replication (GO:0032201)2.35129907
154nucleosome assembly (GO:0006334)2.35065243
155regulation of neurotransmitter secretion (GO:0046928)2.34172611
156gamma-aminobutyric acid signaling pathway (GO:0007214)2.33023464
157synapse assembly (GO:0007416)2.32938638
158exploration behavior (GO:0035640)2.32531164
159positive regulation of fibroblast migration (GO:0010763)2.31035116
160regulation of neuronal synaptic plasticity (GO:0048168)2.30359934
161nuclear pore complex assembly (GO:0051292)2.30048708
162locomotory exploration behavior (GO:0035641)2.29801274
163sister chromatid cohesion (GO:0007062)2.29374772
164regulation of synaptic transmission, GABAergic (GO:0032228)2.28876293
165DNA methylation involved in gamete generation (GO:0043046)2.28621904
166cilium movement (GO:0003341)2.28139010
167* microtubule depolymerization (GO:0007019)2.27661268
168regulation of cAMP-dependent protein kinase activity (GO:2000479)2.27639040
169regulation of meiosis I (GO:0060631)2.27091350
170regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.25223293
171regulation of mitotic spindle checkpoint (GO:1903504)2.25223293
172positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.25156922
173positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.25156922
174positive regulation of mitotic sister chromatid separation (GO:1901970)2.25156922
175protein localization to cilium (GO:0061512)2.24782479
176regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.23480770
177positive regulation of synapse maturation (GO:0090129)2.23352692
178response to histamine (GO:0034776)2.23330177
179negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.23033414
180negative regulation of homotypic cell-cell adhesion (GO:0034111)2.23032448
181layer formation in cerebral cortex (GO:0021819)2.22467975
182regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.21556424
183phosphorylated carbohydrate dephosphorylation (GO:0046838)2.20415086
184inositol phosphate dephosphorylation (GO:0046855)2.20415086
185male meiosis (GO:0007140)2.20122375
186negative regulation of DNA repair (GO:0045738)2.19910694
187regulation of synaptic transmission, glutamatergic (GO:0051966)2.19835880
188transmission of nerve impulse (GO:0019226)2.19477396
189generation of neurons (GO:0048699)2.19155313
190positive regulation of membrane potential (GO:0045838)2.18744674
191regulation of vesicle fusion (GO:0031338)2.18606254
192clathrin coat assembly (GO:0048268)2.18592693
193urinary tract smooth muscle contraction (GO:0014848)2.18222966

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.36673089
2GBX2_23144817_ChIP-Seq_PC3_Human3.75433076
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.71573085
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.45579343
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.92218550
6TAF15_26573619_Chip-Seq_HEK293_Human2.74496078
7SCL_19346495_ChIP-Seq_HPC-7_Human2.74283318
8FUS_26573619_Chip-Seq_HEK293_Human2.41110988
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36884147
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36809012
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.36193539
12* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36080069
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.29004875
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.28691596
15IGF1R_20145208_ChIP-Seq_DFB_Human2.22930404
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10598263
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.09728824
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.08979013
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02914312
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01861101
21* P300_19829295_ChIP-Seq_ESCs_Human2.00960242
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00650548
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.95004263
24SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.92135917
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91178743
26RNF2_27304074_Chip-Seq_NSC_Mouse1.89351556
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.86471791
28EWS_26573619_Chip-Seq_HEK293_Human1.84959113
29SMAD4_21799915_ChIP-Seq_A2780_Human1.83740083
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82375035
31ELK1_19687146_ChIP-ChIP_HELA_Human1.80329893
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.79830616
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.78979351
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78950274
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77946178
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.72433305
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69071429
38REST_21632747_ChIP-Seq_MESCs_Mouse1.68236210
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.64074418
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.63407448
41E2F7_22180533_ChIP-Seq_HELA_Human1.62435261
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62336935
43IRF1_19129219_ChIP-ChIP_H3396_Human1.61764767
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61316224
45STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61251045
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.58311869
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57496717
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57125258
49VDR_22108803_ChIP-Seq_LS180_Human1.55404269
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.52097092
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51989238
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.51464575
53GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49234149
54* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49090537
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.46563896
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.46443473
57CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46242928
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.46239989
59* STAT3_23295773_ChIP-Seq_U87_Human1.43983572
60JUN_21703547_ChIP-Seq_K562_Human1.43607032
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41436733
62RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.38716714
63MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38510130
64TCF4_23295773_ChIP-Seq_U87_Human1.37975385
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37767820
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36212969
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36017058
68AR_21572438_ChIP-Seq_LNCaP_Human1.35942197
69E2F1_18555785_Chip-Seq_ESCs_Mouse1.35552653
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35429583
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35379863
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35379863
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.34413076
74IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34336177
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.34249955
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32506647
77ER_23166858_ChIP-Seq_MCF-7_Human1.32232781
78* AR_25329375_ChIP-Seq_VCAP_Human1.29898192
79RNF2_27304074_Chip-Seq_ESCs_Mouse1.29698691
80ZNF274_21170338_ChIP-Seq_K562_Hela1.28972276
81SOX9_26525672_Chip-Seq_HEART_Mouse1.28492921
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27317582
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.26680584
84RNF2_18974828_ChIP-Seq_MESCs_Mouse1.26291323
85EZH2_18974828_ChIP-Seq_MESCs_Mouse1.26291323
86* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26072403
87E2F1_21310950_ChIP-Seq_MCF-7_Human1.25886037
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.25494510
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24546617
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24463194
91PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24323976
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23325768
93SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22657198
94SALL4_22934838_ChIP-ChIP_CD34+_Human1.21580625
95STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.21567995
96FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.20502640
97P53_22387025_ChIP-Seq_ESCs_Mouse1.20266264
98CMYC_18555785_Chip-Seq_ESCs_Mouse1.19941005
99SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.19736518
100* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19176124
101ELK4_26923725_Chip-Seq_MESODERM_Mouse1.19095529
102MYB_26560356_Chip-Seq_TH2_Human1.18147135
103EED_16625203_ChIP-ChIP_MESCs_Mouse1.18090132
104SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17074657
105CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15944140
106JARID2_20075857_ChIP-Seq_MESCs_Mouse1.15765359
107SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13414864
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13204427
109YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12857254
110RUNX2_22187159_ChIP-Seq_PCA_Human1.11433818
111KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11101296
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10861428
113PRDM14_20953172_ChIP-Seq_ESCs_Human1.10750252
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10440502
115PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09807304
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09444889
117FLI1_21867929_ChIP-Seq_TH2_Mouse1.09274833
118SOX2_21211035_ChIP-Seq_LN229_Gbm1.09268591
119* GATA2_19941826_ChIP-Seq_K562_Human1.08652952
120MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08435903
121RARB_27405468_Chip-Seq_BRAIN_Mouse1.07582244
122REST_18959480_ChIP-ChIP_MESCs_Mouse1.06837742
123FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06697779
124EST1_17652178_ChIP-ChIP_JURKAT_Human1.06016254
125NFE2_27457419_Chip-Seq_LIVER_Mouse1.05677238
126EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05533227
127GATA1_22025678_ChIP-Seq_K562_Human1.05298252
128MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05179387
129NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04954956
130SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04784078
131ARNT_22903824_ChIP-Seq_MCF-7_Human1.04547551
132P300_18555785_Chip-Seq_ESCs_Mouse1.04344043
133TP63_19390658_ChIP-ChIP_HaCaT_Human1.03449377
134POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03435412
135RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03131921
136STAT3_18555785_Chip-Seq_ESCs_Mouse1.03111411
137OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02804699
138IRF8_21731497_ChIP-ChIP_J774_Mouse1.02570352
139* GATA1_19941826_ChIP-Seq_K562_Human1.01769906
140* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00662750
141CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99208078
142VDR_23849224_ChIP-Seq_CD4+_Human0.99009947
143TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97674523
144Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95207303
145* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.94700460
146PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93625082
147OCT4_18555785_Chip-Seq_ESCs_Mouse0.93345655
148CRX_20693478_ChIP-Seq_RETINA_Mouse0.92580088
149* FOXP3_21729870_ChIP-Seq_TREG_Human0.92386922
150NMYC_18555785_Chip-Seq_ESCs_Mouse0.91838903
151RUNX_20019798_ChIP-Seq_JUKART_Human0.90996453
152SPI1_23127762_ChIP-Seq_K562_Human0.89567605
153MYC_18940864_ChIP-ChIP_HL60_Human0.87519138
154SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.87380106

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology6.61101890
2MP0004859_abnormal_synaptic_plasticity3.72808532
3MP0003880_abnormal_central_pattern3.64094093
4MP0003787_abnormal_imprinting3.19657818
5MP0000465_gastrointestinal_hemorrhage3.05131450
6MP0004270_analgesia3.01355976
7MP0008004_abnormal_stomach_pH2.96376390
8MP0008877_abnormal_DNA_methylation2.93833472
9MP0001188_hyperpigmentation2.63054114
10MP0003635_abnormal_synaptic_transmissio2.60708286
11MP0001968_abnormal_touch/_nociception2.57894914
12MP0002735_abnormal_chemical_nociception2.53622249
13MP0002734_abnormal_mechanical_nocicepti2.35549143
14MP0002736_abnormal_nociception_after2.31159151
15MP0002063_abnormal_learning/memory/cond2.28763540
16MP0009745_abnormal_behavioral_response2.22086333
17MP0004957_abnormal_blastocyst_morpholog2.21934703
18MP0001986_abnormal_taste_sensitivity2.13143991
19MP0009046_muscle_twitch2.05925764
20MP0003121_genomic_imprinting2.01808376
21MP0000778_abnormal_nervous_system1.97643008
22MP0003077_abnormal_cell_cycle1.96940111
23MP0002572_abnormal_emotion/affect_behav1.95171678
24MP0003122_maternal_imprinting1.93328144
25MP0006276_abnormal_autonomic_nervous1.92567942
26MP0005083_abnormal_biliary_tract1.91557599
27MP0002398_abnormal_bone_marrow1.86029463
28MP0002064_seizures1.81293539
29MP0003763_abnormal_thymus_physiology1.81281777
30MP0001486_abnormal_startle_reflex1.71385190
31MP0001984_abnormal_olfaction1.69328059
32MP0002272_abnormal_nervous_system1.60647650
33MP0002067_abnormal_sensory_capabilities1.60225081
34MP0005646_abnormal_pituitary_gland1.60193868
35MP0003123_paternal_imprinting1.59892229
36MP0000703_abnormal_thymus_morphology1.59708867
37MP0001835_abnormal_antigen_presentation1.59605466
38MP0002184_abnormal_innervation1.59026433
39MP0004084_abnormal_cardiac_muscle1.58799058
40MP0006292_abnormal_olfactory_placode1.57294630
41MP0005410_abnormal_fertilization1.50131280
42MP0004808_abnormal_hematopoietic_stem1.49827392
43MP0000569_abnormal_digit_pigmentation1.44421193
44MP0005423_abnormal_somatic_nervous1.42264993
45MP0001970_abnormal_pain_threshold1.41990261
46MP0003724_increased_susceptibility_to1.40159776
47MP0005671_abnormal_response_to1.36056729
48* MP0004811_abnormal_neuron_physiology1.35652418
49MP0000689_abnormal_spleen_morphology1.33314579
50MP0005187_abnormal_penis_morphology1.33212433
51MP0001529_abnormal_vocalization1.32356701
52MP0002733_abnormal_thermal_nociception1.32217617
53MP0001730_embryonic_growth_arrest1.31934928
54MP0001440_abnormal_grooming_behavior1.31545893
55MP0010094_abnormal_chromosome_stability1.29137150
56MP0002557_abnormal_social/conspecific_i1.26635689
57MP0002722_abnormal_immune_system1.26478151
58MP0005386_behavior/neurological_phenoty1.23375755
59MP0004924_abnormal_behavior1.23375755
60MP0008057_abnormal_DNA_replication1.22672617
61MP0001905_abnormal_dopamine_level1.22669046
62MP0003693_abnormal_embryo_hatching1.21499171
63MP0003698_abnormal_male_reproductive1.17943818
64MP0001697_abnormal_embryo_size1.17126216
65MP0003718_maternal_effect1.16761327
66MP0008058_abnormal_DNA_repair1.16295573
67MP0001501_abnormal_sleep_pattern1.16026437
68* MP0002882_abnormal_neuron_morphology1.15146379
69MP0002396_abnormal_hematopoietic_system1.14964506
70MP0005174_abnormal_tail_pigmentation1.14574000
71MP0005623_abnormal_meninges_morphology1.14447595
72MP0009697_abnormal_copulation1.14058177
73MP0005394_taste/olfaction_phenotype1.13645961
74MP0005499_abnormal_olfactory_system1.13645961
75MP0008872_abnormal_physiological_respon1.13581965
76MP0000631_abnormal_neuroendocrine_gland1.12077878
77MP0010352_gastrointestinal_tract_polyps1.11104062
78MP0000350_abnormal_cell_proliferation1.10685300
79MP0002429_abnormal_blood_cell1.10301089
80MP0000955_abnormal_spinal_cord1.08929077
81MP0002160_abnormal_reproductive_system1.08779150
82MP0005084_abnormal_gallbladder_morpholo1.08405106
83MP0002102_abnormal_ear_morphology1.05584012
84* MP0002152_abnormal_brain_morphology1.03675974
85MP0008789_abnormal_olfactory_epithelium1.03604303
86MP0000015_abnormal_ear_pigmentation1.03036650
87MP0005171_absent_coat_pigmentation1.02476782
88MP0002210_abnormal_sex_determination1.02102174
89MP0004510_myositis1.01409665
90MP0002019_abnormal_tumor_incidence1.01135396
91MP0002751_abnormal_autonomic_nervous1.01049600
92MP0001929_abnormal_gametogenesis1.01036036
93MP0000566_synostosis1.00506814
94MP0008569_lethality_at_weaning1.00473396
95MP0000490_abnormal_crypts_of0.99374882
96* MP0003861_abnormal_nervous_system0.99068897
97MP0005409_darkened_coat_color0.99022723
98MP0001800_abnormal_humoral_immune0.96611986
99MP0008961_abnormal_basal_metabolism0.96567189
100MP0001851_eye_inflammation0.96532000
101MP0000716_abnormal_immune_system0.95433986
102MP0009250_abnormal_appendicular_skeleto0.94825321
103MP0001545_abnormal_hematopoietic_system0.93703666
104MP0005397_hematopoietic_system_phenotyp0.93703666
105MP0005645_abnormal_hypothalamus_physiol0.93654868
106MP0002009_preneoplasia0.93512255
107MP0003566_abnormal_cell_adhesion0.92460393
108MP0000313_abnormal_cell_death0.92122490
109MP0003385_abnormal_body_wall0.91984831
110MP0002066_abnormal_motor_capabilities/c0.91364623
111MP0002163_abnormal_gland_morphology0.90828292
112MP0000516_abnormal_urinary_system0.89968723
113MP0005367_renal/urinary_system_phenotyp0.89968723
114MP0003890_abnormal_embryonic-extraembry0.89570526
115MP0001672_abnormal_embryogenesis/_devel0.89545254
116MP0005380_embryogenesis_phenotype0.89545254
117MP0001177_atelectasis0.88937723
118MP0002086_abnormal_extraembryonic_tissu0.88236129
119MP0002084_abnormal_developmental_patter0.87127222
120MP0008775_abnormal_heart_ventricle0.86849870
121MP0002752_abnormal_somatic_nervous0.85873686
122MP0006035_abnormal_mitochondrial_morpho0.84783734
123MP0003755_abnormal_palate_morphology0.83530806
124MP0003221_abnormal_cardiomyocyte_apopto0.82891501
125MP0009703_decreased_birth_body0.82670838
126MP0004142_abnormal_muscle_tone0.82505041
127MP0009780_abnormal_chondrocyte_physiolo0.82362241
128MP0002080_prenatal_lethality0.82006686
129MP0008770_decreased_survivor_rate0.81044705
130MP0005384_cellular_phenotype0.80263558
131MP0003984_embryonic_growth_retardation0.80176320
132MP0003111_abnormal_nucleus_morphology0.80030423
133MP0001963_abnormal_hearing_physiology0.79861649
134MP0005621_abnormal_cell_physiology0.79656424
135MP0009765_abnormal_xenobiotic_induced0.79226037
136MP0000358_abnormal_cell_content/0.78625327
137MP0002088_abnormal_embryonic_growth/wei0.78405291
138MP0001145_abnormal_male_reproductive0.78013719
139MP0002420_abnormal_adaptive_immunity0.77511422
140MP0004858_abnormal_nervous_system0.77502308
141MP0003567_abnormal_fetal_cardiomyocyte0.76690859
142MP0008007_abnormal_cellular_replicative0.76150724
143MP0003879_abnormal_hair_cell0.76115063
144MP0000653_abnormal_sex_gland0.75998785
145MP0001879_abnormal_lymphatic_vessel0.74813377
146MP0003638_abnormal_response/metabolism_0.74534146
147MP0001819_abnormal_immune_cell0.74428929
148MP0005551_abnormal_eye_electrophysiolog0.73505035
149MP0004742_abnormal_vestibular_system0.73243416
150MP0001299_abnormal_eye_distance/0.72995645
151MP0003303_peritoneal_inflammation0.72761513
152MP0005000_abnormal_immune_tolerance0.72620957
153MP0000026_abnormal_inner_ear0.72175677
154MP0003656_abnormal_erythrocyte_physiolo0.71703213
155MP0002653_abnormal_ependyma_morphology0.71492155
156MP0009763_increased_sensitivity_to0.70789584
157MP0002723_abnormal_immune_serum0.70432943
158* MP0002081_perinatal_lethality0.70321627
159MP0000230_abnormal_systemic_arterial0.70076735
160MP0001502_abnormal_circadian_rhythm0.70037986
161MP0002161_abnormal_fertility/fecundity0.68457956
162MP0002085_abnormal_embryonic_tissue0.68295194
163MP0004197_abnormal_fetal_growth/weight/0.68180817
164MP0002095_abnormal_skin_pigmentation0.67482314
165MP0003183_abnormal_peptide_metabolism0.67294936
166MP0003937_abnormal_limbs/digits/tail_de0.67119233
167MP0008932_abnormal_embryonic_tissue0.66363183
168MP0002116_abnormal_craniofacial_bone0.65352432
169MP0004147_increased_porphyrin_level0.65347713
170MP0000049_abnormal_middle_ear0.62751234

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)8.62177890
2Prolonged bleeding time (HP:0003010)8.31262767
3Abnormal platelet volume (HP:0011876)8.06712193
4Menorrhagia (HP:0000132)7.24733713
5Petechiae (HP:0000967)6.48155574
6Epistaxis (HP:0000421)5.22338978
7Purpura (HP:0000979)5.17288245
8Gingival bleeding (HP:0000225)4.70715654
9Focal motor seizures (HP:0011153)4.61240489
10Febrile seizures (HP:0002373)4.37255136
11Epileptic encephalopathy (HP:0200134)4.03035626
12Atonic seizures (HP:0010819)3.97673503
13Impaired platelet aggregation (HP:0003540)3.78263280
14Abnormal platelet function (HP:0011869)3.78263280
15Abnormal hair whorl (HP:0010721)3.55195951
16Acanthocytosis (HP:0001927)3.53917841
17Poikilocytosis (HP:0004447)3.35348158
18Dyschromatopsia (HP:0007641)3.32891940
19Focal seizures (HP:0007359)3.20100035
20Abnormality of the labia minora (HP:0012880)3.18169067
21Spontaneous hematomas (HP:0007420)3.10801686
22Progressive cerebellar ataxia (HP:0002073)2.98036455
23Papillary thyroid carcinoma (HP:0002895)2.97038665
24Conjunctival telangiectasia (HP:0000524)2.89870896
25Gait imbalance (HP:0002141)2.82222705
26Hyperventilation (HP:0002883)2.78215308
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.71961723
28Absent/shortened dynein arms (HP:0200106)2.71961723
29Medial flaring of the eyebrow (HP:0010747)2.71575106
30Myelodysplasia (HP:0002863)2.66261698
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.63728920
32Absence seizures (HP:0002121)2.54494724
33Congenital primary aphakia (HP:0007707)2.50544799
34Uterine leiomyosarcoma (HP:0002891)2.50256830
35Leiomyosarcoma (HP:0100243)2.50256830
36Volvulus (HP:0002580)2.49481907
37Broad-based gait (HP:0002136)2.48362050
38Transitional cell carcinoma of the bladder (HP:0006740)2.48217020
39Hyperlipoproteinemia (HP:0010980)2.46119202
40Thyroid carcinoma (HP:0002890)2.44760046
41Myokymia (HP:0002411)2.44510543
42Abnormal auditory evoked potentials (HP:0006958)2.39556357
43Abnormality of the vasculature of the conjunctiva (HP:0008054)2.37223518
44Protruding tongue (HP:0010808)2.37211664
45Abnormality of chromosome stability (HP:0003220)2.35193963
46Upper limb muscle weakness (HP:0003484)2.34819974
47Medulloblastoma (HP:0002885)2.34219968
48Abnormal respiratory motile cilium physiology (HP:0012261)2.33934370
49Nephrogenic diabetes insipidus (HP:0009806)2.31626491
50Pancreatic fibrosis (HP:0100732)2.31046885
51Gaze-evoked nystagmus (HP:0000640)2.30496437
52Bladder neoplasm (HP:0009725)2.29893332
53Bladder carcinoma (HP:0002862)2.29893332
54Abnormal respiratory motile cilium morphology (HP:0005938)2.29306590
55Abnormal respiratory epithelium morphology (HP:0012253)2.29306590
56Abnormal ciliary motility (HP:0012262)2.27546060
57Abnormality of the heme biosynthetic pathway (HP:0010472)2.27300559
58Dialeptic seizures (HP:0011146)2.25035256
59T lymphocytopenia (HP:0005403)2.24410263
60Increased density of long bones (HP:0006392)2.23725962
61Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.21974548
62Chromsome breakage (HP:0040012)2.21544109
63Cortical dysplasia (HP:0002539)2.15898039
64Abnormality of lateral ventricle (HP:0030047)2.15748865
65Genetic anticipation (HP:0003743)2.15049898
66Amaurosis fugax (HP:0100576)2.13936455
67Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.10675888
68Poor coordination (HP:0002370)2.09254852
69Chromosomal breakage induced by crosslinking agents (HP:0003221)2.07780447
70Malignant gastrointestinal tract tumors (HP:0006749)2.07488967
71Gastrointestinal carcinoma (HP:0002672)2.07488967
72Drooling (HP:0002307)2.07129447
73Excessive salivation (HP:0003781)2.07129447
74Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.07060758
75Degeneration of the lateral corticospinal tracts (HP:0002314)2.07060758
76Absent eyebrow (HP:0002223)2.03439487
77Generalized tonic-clonic seizures (HP:0002069)2.03437565
78Abnormality of T cell number (HP:0011839)2.02754233
79Abnormality of midbrain morphology (HP:0002418)2.02456675
80Molar tooth sign on MRI (HP:0002419)2.02456675
81Genital tract atresia (HP:0001827)2.01635538
82Panhypogammaglobulinemia (HP:0003139)2.00298218
83Visual hallucinations (HP:0002367)1.99709351
84Fetal akinesia sequence (HP:0001989)1.98643047
85Aqueductal stenosis (HP:0002410)1.96990948
86Autoimmune hemolytic anemia (HP:0001890)1.96453573
87Acute myeloid leukemia (HP:0004808)1.95134766
88Nephroblastoma (Wilms tumor) (HP:0002667)1.94422656
89Progressive inability to walk (HP:0002505)1.94348064
90Absent speech (HP:0001344)1.93128687
91Inappropriate behavior (HP:0000719)1.93070399
92Vaginal atresia (HP:0000148)1.92673741
93Nephronophthisis (HP:0000090)1.92308443
94Colon cancer (HP:0003003)1.92080370
95Thyroid-stimulating hormone excess (HP:0002925)1.91694665
96Embryonal renal neoplasm (HP:0011794)1.91425702
97Biliary tract neoplasm (HP:0100574)1.90757191
98Urinary bladder sphincter dysfunction (HP:0002839)1.89594290
99Rhinitis (HP:0012384)1.88691470
100IgM deficiency (HP:0002850)1.88672695
101Bruising susceptibility (HP:0000978)1.87115676
102Gastroesophageal reflux (HP:0002020)1.86208761
103Abnormality of the common coagulation pathway (HP:0010990)1.81887092
104Urinary urgency (HP:0000012)1.79897796
105Ectopic kidney (HP:0000086)1.78133547
106Abnormal pupillary function (HP:0007686)1.78081497
107Abnormality of the prostate (HP:0008775)1.77244566
108Amyotrophic lateral sclerosis (HP:0007354)1.76396573
109Specific learning disability (HP:0001328)1.75866765
110Hypothermia (HP:0002045)1.73819447
111Cystic hygroma (HP:0000476)1.73699407
112Neoplasm of the oral cavity (HP:0100649)1.73279993
113Deep philtrum (HP:0002002)1.73259361
114Abnormality of incisor morphology (HP:0011063)1.72274030
115Facial hemangioma (HP:0000329)1.72047689
116Renal cortical cysts (HP:0000803)1.71753117
117Inability to walk (HP:0002540)1.71023307
118IgA deficiency (HP:0002720)1.69559960
119Abnormality of the nasal septum (HP:0000419)1.69514040
120Aplasia/Hypoplasia of the uvula (HP:0010293)1.69412262
121Asymmetry of the thorax (HP:0001555)1.68973823
122Aplasia/Hypoplasia of the sternum (HP:0006714)1.68532322
123Syringomyelia (HP:0003396)1.67134832
124Spinal cord lesions (HP:0100561)1.67134832
125Abnormality of chromosome segregation (HP:0002916)1.65674313
126Neoplasm of the small intestine (HP:0100833)1.65419261
127Amblyopia (HP:0000646)1.64983989
128Fair hair (HP:0002286)1.64661822
129Poor suck (HP:0002033)1.64010557
130Aplasia/Hypoplasia of the lens (HP:0008063)1.63896373
131Failure to thrive in infancy (HP:0001531)1.63498295
132Acute lymphatic leukemia (HP:0006721)1.62847184
133True hermaphroditism (HP:0010459)1.62792597
134Supernumerary spleens (HP:0009799)1.62019921
135Poor eye contact (HP:0000817)1.61459125
136Termporal pattern (HP:0011008)1.61361174
137Insidious onset (HP:0003587)1.61361174
138Postaxial hand polydactyly (HP:0001162)1.61341915
139Tinnitus (HP:0000360)1.60320812
140Truncal ataxia (HP:0002078)1.59935066
141Encephalitis (HP:0002383)1.59487526
142Basal cell carcinoma (HP:0002671)1.58766894
143Impaired vibration sensation in the lower limbs (HP:0002166)1.58674515
144Generalized hypopigmentation of hair (HP:0011358)1.58226384
145Limb dystonia (HP:0002451)1.57081983
146Capillary hemangiomas (HP:0005306)1.56399301
147Meckel diverticulum (HP:0002245)1.55936099
148Narrow forehead (HP:0000341)1.55319475
149Increased number of teeth (HP:0011069)1.54791868
150Akinesia (HP:0002304)1.54342376
151Microglossia (HP:0000171)1.54102104
152Curly hair (HP:0002212)1.53472021
153Epileptiform EEG discharges (HP:0011182)1.52845017
154Astigmatism (HP:0000483)1.52529068
155Duodenal stenosis (HP:0100867)1.52127721
156Small intestinal stenosis (HP:0012848)1.52127721
157Neoplasm of the adrenal cortex (HP:0100641)1.51052663
158Abnormality of the ileum (HP:0001549)1.49919547
159Birth length less than 3rd percentile (HP:0003561)1.49683173
160Impaired smooth pursuit (HP:0007772)1.49518318
161Short foot (HP:0001773)1.49460473
162Clubbing of toes (HP:0100760)1.49114270
163Impaired vibratory sensation (HP:0002495)1.47885114
164Heterochromia iridis (HP:0001100)1.47666231
165Aplasia/Hypoplasia of the tongue (HP:0010295)1.46566459
166Abnormality of salivation (HP:0100755)1.46234643
167Absent frontal sinuses (HP:0002688)1.46227132
168Abnormality of T cells (HP:0002843)1.45730339
169Abnormality of the corticospinal tract (HP:0002492)1.45186461
170Postaxial foot polydactyly (HP:0001830)1.44975957
171Aganglionic megacolon (HP:0002251)1.43427134
172Chest pain (HP:0100749)1.43276241
173Increased IgM level (HP:0003496)1.43146762
174Abnormality of the preputium (HP:0100587)1.42713267
175Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.41736190
176Short 4th metacarpal (HP:0010044)1.41736190
177IgG deficiency (HP:0004315)1.41458423
178Prominent nose (HP:0000448)1.41208995
179Heterotopia (HP:0002282)1.40919481
180Rhabdomyosarcoma (HP:0002859)1.40731418

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.85016406
2MST43.29992848
3MAP2K73.06002494
4AKT32.85067426
5NTRK32.78707092
6MARK12.75109918
7SIK32.66759812
8TEC2.58725878
9PLK22.55916526
10MAP3K42.50726665
11BMX2.35338340
12TAOK32.33107161
13MAPK132.27617522
14MINK12.18165828
15PRPF4B2.09453546
16MAP3K122.04403106
17PRKD31.97133892
18BTK1.95273114
19MKNK21.92237813
20ERBB31.91791959
21CDC71.89669108
22STK31.87094948
23SGK21.82535064
24TRIM281.80494917
25MKNK11.73648760
26SYK1.56010268
27PLK31.47348432
28CCNB11.45749338
29BCR1.45491205
30EPHA41.42517898
31MAP3K91.39060480
32CAMK1G1.37620471
33KSR11.37525903
34CAMKK21.36781942
35CDK81.34813193
36LATS21.33008398
37PNCK1.30773691
38MAP3K101.29437690
39YES11.28907270
40PIK3CG1.24738970
41FRK1.24494207
42SGK2231.18640801
43SGK4941.18640801
44NEK61.16861425
45SGK31.12352677
46HCK1.11387482
47TSSK61.07087270
48CDK31.06221684
49BMPR21.05120736
50EIF2AK31.04273740
51TTK1.03783736
52FGR1.03072755
53CSF1R1.02437200
54STK40.99023379
55PDK30.98522645
56PDK40.98522645
57TXK0.98278898
58NTRK20.96877205
59NEK20.96395971
60MAP2K40.95620441
61NUAK10.94291234
62GRK50.94006517
63CDK190.90785990
64PRKCG0.87571462
65NLK0.86873999
66BMPR1B0.85792776
67STK240.81536850
68SRPK10.81352839
69DAPK10.81012184
70CHEK20.79524573
71EPHA30.79140493
72BRAF0.79108947
73ITK0.79032015
74CSNK1G20.78355185
75DYRK20.76480815
76STK38L0.75971292
77DYRK30.74687304
78RIPK40.74530059
79FES0.71125659
80PLK40.69650501
81CDK50.68346366
82TAF10.67569067
83SIK20.67477598
84CDK180.67308873
85RPS6KB10.66305155
86BRSK10.65825936
87WEE10.64740953
88PTK2B0.63814646
89CLK10.63155071
90DYRK1A0.62995683
91PIM10.62633426
92WNK30.61343370
93CAMK1D0.60011390
94BRD40.59554730
95RPS6KA40.59429711
96LYN0.59369098
97CDK140.59200488
98CAMK2A0.58873633
99ADRBK20.58652619
100IRAK10.58194708
101PRKCH0.56933165
102MAP3K60.56918822
103SGK10.55201601
104ACVR1B0.55067467
105PRKCE0.55001326
106CSNK1G30.54929018
107BUB10.54872774
108PDK20.53012829
109LCK0.52762594
110PDGFRB0.52535776
111BRSK20.52416220
112PLK10.51900350
113VRK10.51719769
114CSNK1A1L0.50960995
115PAK10.50455799
116CDK150.50148802
117IRAK20.49546706
118ATM0.47552829
119CDK120.46612713
120ILK0.45924310
121RAF10.45115746
122JAK30.45055628
123SCYL20.44942653
124CDK11A0.43420881
125WNK10.43327239
126PRKG10.43058257
127CDK10.42411301
128ERBB20.42363332
129CSNK1G10.42222728
130ZAK0.42010077
131EIF2AK10.41411066
132CSNK1E0.40418646
133CHEK10.39346229
134MAP4K20.39176743
135NEK10.38949071
136DAPK20.38551370
137EGFR0.38025498
138PBK0.38021311
139ATR0.37274728
140RPS6KA20.37189422
141TNIK0.36918348
142UHMK10.36148739
143GSK3B0.34400882
144PAK60.33870506
145ERBB40.33869778
146MAPK100.33152150
147LATS10.31977450
148MUSK0.31946086
149CDK20.31129648
150PRKCB0.30603651

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046113.71278628
2Mismatch repair_Homo sapiens_hsa034303.36639670
3Nicotine addiction_Homo sapiens_hsa050332.93267952
4Synaptic vesicle cycle_Homo sapiens_hsa047212.56848617
5DNA replication_Homo sapiens_hsa030302.27034648
6Olfactory transduction_Homo sapiens_hsa047402.17827819
7Long-term potentiation_Homo sapiens_hsa047202.10519635
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.87483587
9Phototransduction_Homo sapiens_hsa047441.85954066
10Circadian entrainment_Homo sapiens_hsa047131.85924301
11Amphetamine addiction_Homo sapiens_hsa050311.82522627
12Morphine addiction_Homo sapiens_hsa050321.81371887
13Dopaminergic synapse_Homo sapiens_hsa047281.74637815
14Glutamatergic synapse_Homo sapiens_hsa047241.70496826
15Oocyte meiosis_Homo sapiens_hsa041141.62709521
16GABAergic synapse_Homo sapiens_hsa047271.61851248
17Serotonergic synapse_Homo sapiens_hsa047261.60696031
18Taste transduction_Homo sapiens_hsa047421.60692160
19Hematopoietic cell lineage_Homo sapiens_hsa046401.58620281
20Collecting duct acid secretion_Homo sapiens_hsa049661.57456786
21T cell receptor signaling pathway_Homo sapiens_hsa046601.55022490
22Primary immunodeficiency_Homo sapiens_hsa053401.53281135
23Long-term depression_Homo sapiens_hsa047301.43351584
24Systemic lupus erythematosus_Homo sapiens_hsa053221.40616403
25B cell receptor signaling pathway_Homo sapiens_hsa046621.36741749
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.35307194
27Pancreatic cancer_Homo sapiens_hsa052121.35115931
28Cholinergic synapse_Homo sapiens_hsa047251.34259377
29Cell cycle_Homo sapiens_hsa041101.29743340
30Viral carcinogenesis_Homo sapiens_hsa052031.29631163
31Chemokine signaling pathway_Homo sapiens_hsa040621.28746873
32Axon guidance_Homo sapiens_hsa043601.24446129
33Fanconi anemia pathway_Homo sapiens_hsa034601.22992478
34Basal transcription factors_Homo sapiens_hsa030221.22201799
35Shigellosis_Homo sapiens_hsa051311.20759244
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20227400
37Steroid biosynthesis_Homo sapiens_hsa001001.18260726
38Salivary secretion_Homo sapiens_hsa049701.17256637
39mRNA surveillance pathway_Homo sapiens_hsa030151.16643517
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16297042
41Renin secretion_Homo sapiens_hsa049241.15338865
42ErbB signaling pathway_Homo sapiens_hsa040121.14577399
43Insulin secretion_Homo sapiens_hsa049111.11936115
44Glioma_Homo sapiens_hsa052141.11413736
45Base excision repair_Homo sapiens_hsa034101.10580588
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08247002
47Calcium signaling pathway_Homo sapiens_hsa040201.07894487
48Adherens junction_Homo sapiens_hsa045201.07576831
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06589116
50Chronic myeloid leukemia_Homo sapiens_hsa052201.06116509
51Oxytocin signaling pathway_Homo sapiens_hsa049211.05274749
52Cocaine addiction_Homo sapiens_hsa050301.04636633
53Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03719315
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03055927
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02821513
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00165485
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99938027
58Dorso-ventral axis formation_Homo sapiens_hsa043200.99053785
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98751013
60RNA degradation_Homo sapiens_hsa030180.97868105
61Colorectal cancer_Homo sapiens_hsa052100.96726180
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95913917
63Melanoma_Homo sapiens_hsa052180.95240298
64Gap junction_Homo sapiens_hsa045400.95217675
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.93402818
66cAMP signaling pathway_Homo sapiens_hsa040240.92294517
67Vibrio cholerae infection_Homo sapiens_hsa051100.91837210
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91472874
69Gastric acid secretion_Homo sapiens_hsa049710.91415236
70Measles_Homo sapiens_hsa051620.90716728
71Endometrial cancer_Homo sapiens_hsa052130.90544157
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90439967
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88955447
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87508811
75Melanogenesis_Homo sapiens_hsa049160.87232027
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86770193
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85985995
78Wnt signaling pathway_Homo sapiens_hsa043100.84376925
79GnRH signaling pathway_Homo sapiens_hsa049120.82257095
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79381646
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79150192
82RNA transport_Homo sapiens_hsa030130.78379252
83MAPK signaling pathway_Homo sapiens_hsa040100.77636504
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75640770
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74874184
86p53 signaling pathway_Homo sapiens_hsa041150.72974887
87Alcoholism_Homo sapiens_hsa050340.72951366
88One carbon pool by folate_Homo sapiens_hsa006700.72435341
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72196318
90Endocytosis_Homo sapiens_hsa041440.71394265
91Estrogen signaling pathway_Homo sapiens_hsa049150.70651105
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.70006510
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69364979
94Ras signaling pathway_Homo sapiens_hsa040140.67931443
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67619848
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.66245099
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.63898572
98Non-homologous end-joining_Homo sapiens_hsa034500.63654039
99Rheumatoid arthritis_Homo sapiens_hsa053230.63034328
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62928683
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.61963519
102Rap1 signaling pathway_Homo sapiens_hsa040150.61175537
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60871562
104Homologous recombination_Homo sapiens_hsa034400.60258716
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59967605
106Pancreatic secretion_Homo sapiens_hsa049720.59295840
107RNA polymerase_Homo sapiens_hsa030200.57688758
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.57627628
109Huntingtons disease_Homo sapiens_hsa050160.56467186
110Renal cell carcinoma_Homo sapiens_hsa052110.56117673
111Pyrimidine metabolism_Homo sapiens_hsa002400.56099522
112Nitrogen metabolism_Homo sapiens_hsa009100.55894307
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54736179
114Prostate cancer_Homo sapiens_hsa052150.54212576
115ECM-receptor interaction_Homo sapiens_hsa045120.53324109
116Phagosome_Homo sapiens_hsa041450.53134991
117Type I diabetes mellitus_Homo sapiens_hsa049400.52652559
118Choline metabolism in cancer_Homo sapiens_hsa052310.52591975
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52560423
120Non-small cell lung cancer_Homo sapiens_hsa052230.51715294
121Hippo signaling pathway_Homo sapiens_hsa043900.51221102
122Thyroid cancer_Homo sapiens_hsa052160.51030666
123FoxO signaling pathway_Homo sapiens_hsa040680.50958917
124Small cell lung cancer_Homo sapiens_hsa052220.50762954
125Herpes simplex infection_Homo sapiens_hsa051680.49912755
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47989904
127Inositol phosphate metabolism_Homo sapiens_hsa005620.47602748
128Nucleotide excision repair_Homo sapiens_hsa034200.47492481
129MicroRNAs in cancer_Homo sapiens_hsa052060.46715350
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46504625
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46442299
132TGF-beta signaling pathway_Homo sapiens_hsa043500.46113200
133Spliceosome_Homo sapiens_hsa030400.45968241
134Purine metabolism_Homo sapiens_hsa002300.45899854
135mTOR signaling pathway_Homo sapiens_hsa041500.45562108
136Acute myeloid leukemia_Homo sapiens_hsa052210.45474965
137Epstein-Barr virus infection_Homo sapiens_hsa051690.44885073
138Hepatitis B_Homo sapiens_hsa051610.44299841
139Salmonella infection_Homo sapiens_hsa051320.43401898
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.42504044
141Pathways in cancer_Homo sapiens_hsa052000.42118866
142Apoptosis_Homo sapiens_hsa042100.39572478

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »