KIF2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.89484033
2motile cilium assembly (GO:0044458)9.76659127
3spermatid development (GO:0007286)9.63635498
4regulation of cilium movement (GO:0003352)8.73825950
5response to pheromone (GO:0019236)8.63363235
6cilium movement (GO:0003341)8.18178793
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.80792785
8single fertilization (GO:0007338)7.73124644
9piRNA metabolic process (GO:0034587)7.38691490
10sperm capacitation (GO:0048240)7.25856451
11male meiosis (GO:0007140)7.22378689
12rRNA methylation (GO:0031167)7.16572645
13protein targeting to Golgi (GO:0000042)7.10470010
14synaptonemal complex organization (GO:0070193)7.05495031
15synaptonemal complex assembly (GO:0007130)6.86248455
16establishment of protein localization to Golgi (GO:0072600)6.81941241
17negative regulation of inclusion body assembly (GO:0090084)6.70024703
18retrograde transport, vesicle recycling within Golgi (GO:0000301)6.62663793
19spermatogenesis (GO:0007283)6.54886461
20phosphatidylethanolamine biosynthetic process (GO:0006646)6.53543234
21male gamete generation (GO:0048232)6.52517265
22fertilization (GO:0009566)6.46198937
23organic cation transport (GO:0015695)6.31262334
24phosphatidylethanolamine metabolic process (GO:0046337)6.03281066
25rRNA modification (GO:0000154)6.02503830
26gamete generation (GO:0007276)6.00122311
27regulation of inclusion body assembly (GO:0090083)5.63569938
28calcium ion-dependent exocytosis (GO:0017156)5.54521844
29cellular ketone body metabolic process (GO:0046950)5.50410520
30cellular process involved in reproduction in multicellular organism (GO:0022412)5.40659249
31germ cell development (GO:0007281)5.38371702
32ventricular system development (GO:0021591)5.26176302
33positive regulation of Rab GTPase activity (GO:0032851)5.19766231
34regulation of Rab GTPase activity (GO:0032313)5.19766231
35regulation of microtubule-based movement (GO:0060632)5.15301657
36cell recognition (GO:0008037)5.15214371
37protein localization to Golgi apparatus (GO:0034067)5.09355142
38ketone body metabolic process (GO:1902224)4.85569160
39male meiosis I (GO:0007141)4.83947021
40glycerol ether metabolic process (GO:0006662)4.80511630
41spermatid nucleus differentiation (GO:0007289)4.80355033
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.79812437
43DNA methylation involved in gamete generation (GO:0043046)4.74088447
44chromosome organization involved in meiosis (GO:0070192)4.73905526
45multicellular organismal reproductive process (GO:0048609)4.73212505
46microtubule severing (GO:0051013)4.66716592
47regulation of transcription involved in cell fate commitment (GO:0060850)4.63702978
48chromosome condensation (GO:0030261)4.49592699
49chromatin silencing (GO:0006342)4.48425110
50seminiferous tubule development (GO:0072520)4.47065462
51ether metabolic process (GO:0018904)4.44159705
52left/right pattern formation (GO:0060972)4.31604614
53meiotic nuclear division (GO:0007126)4.27395985
54DNA packaging (GO:0006323)4.26774872
55chaperone-mediated protein complex assembly (GO:0051131)4.11902926
56musculoskeletal movement (GO:0050881)3.88356737
57multicellular organismal movement (GO:0050879)3.88356737
58coenzyme catabolic process (GO:0009109)3.87046858
59meiosis I (GO:0007127)3.86129444
60multicellular organismal development (GO:0007275)3.81044088
61glomerular visceral epithelial cell development (GO:0072015)3.78546404
62monoubiquitinated protein deubiquitination (GO:0035520)3.68000998
63glomerular epithelial cell development (GO:0072310)3.62584179
64negative regulation of Rho protein signal transduction (GO:0035024)3.60729031
65genitalia morphogenesis (GO:0035112)3.58214191
66single strand break repair (GO:0000012)3.55077228
67protein polyglutamylation (GO:0018095)3.50813985
68membrane protein intracellular domain proteolysis (GO:0031293)3.49117584
69sexual reproduction (GO:0019953)3.48891982
70response to acidic pH (GO:0010447)3.47595657
71polyamine biosynthetic process (GO:0006596)3.46573915
72microtubule nucleation (GO:0007020)3.42679900
73protein localization to cilium (GO:0061512)3.41850043
74protein K11-linked deubiquitination (GO:0035871)3.40856339
75nucleosome disassembly (GO:0006337)3.38337902
76protein-DNA complex disassembly (GO:0032986)3.38337902
77meiotic cell cycle (GO:0051321)3.36609674
78peptidyl-threonine dephosphorylation (GO:0035970)3.33445177
79cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.33436912
80cellular response to pH (GO:0071467)3.32688878
81regulation of spindle checkpoint (GO:0090231)3.26515947
82cerebral cortex neuron differentiation (GO:0021895)3.26471416
83sequestering of actin monomers (GO:0042989)3.21434445
84polyol catabolic process (GO:0046174)3.20451833
85histone H3-K9 demethylation (GO:0033169)3.19312726
86carnitine transport (GO:0015879)3.17859527
87amino-acid betaine transport (GO:0015838)3.17859527
88regulation of interleukin-13 production (GO:0032656)3.17515871
89protein refolding (GO:0042026)3.15895012
90homeostasis of number of cells within a tissue (GO:0048873)3.10907248
91alditol metabolic process (GO:0019400)3.08776462
92glycolytic process (GO:0006096)3.05969622
93regulation of T-helper 2 cell differentiation (GO:0045628)3.05547726
94negative regulation of gene expression, epigenetic (GO:0045814)3.04110945
95nucleoside diphosphate phosphorylation (GO:0006165)3.04024219
96carnitine transmembrane transport (GO:1902603)3.01813302
97mesenchymal cell differentiation involved in kidney development (GO:0072161)2.95583349
98mesenchymal cell differentiation involved in renal system development (GO:2001012)2.95583349
99DNA conformation change (GO:0071103)2.95033233
100mitotic sister chromatid cohesion (GO:0007064)2.93708326
101* microtubule polymerization or depolymerization (GO:0031109)2.93639356
102nucleus organization (GO:0006997)2.93224261
103regulation of phosphoprotein phosphatase activity (GO:0043666)2.92550282
104cilium organization (GO:0044782)2.90710129
105synapsis (GO:0007129)2.88632068
106intraciliary transport (GO:0042073)2.86002627
107cilium morphogenesis (GO:0060271)2.85880761
108cell differentiation involved in metanephros development (GO:0072202)2.85715781
109GTP biosynthetic process (GO:0006183)2.85703087
110cranial nerve morphogenesis (GO:0021602)2.82981098
111interferon-gamma secretion (GO:0072643)2.82215612
112Golgi to endosome transport (GO:0006895)2.82155061
113cilium assembly (GO:0042384)2.80343110
114mitotic G1 DNA damage checkpoint (GO:0031571)2.80073576
115lactate metabolic process (GO:0006089)2.79985438
116axoneme assembly (GO:0035082)2.79620293
117cellular component assembly involved in morphogenesis (GO:0010927)2.77937386
118meiotic cell cycle process (GO:1903046)2.76760537
119receptor recycling (GO:0001881)2.74358233
120gene silencing by RNA (GO:0031047)2.73122258
121positive regulation of macrophage activation (GO:0043032)2.71333373
122centriole assembly (GO:0098534)2.70590211
123regulation of ARF GTPase activity (GO:0032312)2.70429225
124positive regulation of guanylate cyclase activity (GO:0031284)2.70137282
125NAD biosynthetic process (GO:0009435)2.69429329
126* microtubule-based movement (GO:0007018)2.69247283
127negative regulation of organelle assembly (GO:1902116)2.67320182
128negative regulation of histone methylation (GO:0031061)2.66870951
129glycerol metabolic process (GO:0006071)2.61770524
130RNA localization (GO:0006403)2.61695528
131regulation of cilium assembly (GO:1902017)2.58469270
132UTP biosynthetic process (GO:0006228)2.54600877
133peptidyl-glutamic acid modification (GO:0018200)2.51838222
134RNA destabilization (GO:0050779)2.45701231
135single-organism membrane fusion (GO:0044801)2.39773231
136regulation of centriole replication (GO:0046599)2.36126514
137centriole replication (GO:0007099)2.33787161
138fusion of sperm to egg plasma membrane (GO:0007342)14.5520857
139sperm motility (GO:0030317)13.6332852
140cell wall macromolecule metabolic process (GO:0044036)13.5335946
141cell wall macromolecule catabolic process (GO:0016998)13.5335946
142acrosome assembly (GO:0001675)12.0186680
143acrosome reaction (GO:0007340)11.8836810
144sperm-egg recognition (GO:0035036)11.8366612
145multicellular organism reproduction (GO:0032504)11.7251033
146plasma membrane fusion (GO:0045026)11.0954137
147cell-cell recognition (GO:0009988)10.6054520
148binding of sperm to zona pellucida (GO:0007339)10.5809033
149cilium or flagellum-dependent cell motility (GO:0001539)10.2165438
150axonemal dynein complex assembly (GO:0070286)10.1607179
151epithelial cilium movement (GO:0003351)10.0005379

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.79155743
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.48469858
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.26975882
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.21058607
5EZH2_22144423_ChIP-Seq_EOC_Human3.93885965
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.76385734
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.43331857
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.04470868
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.93657607
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.57894014
11VDR_22108803_ChIP-Seq_LS180_Human2.33177735
12* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.19326629
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.17241375
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.14089061
15VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.11451084
16ZNF274_21170338_ChIP-Seq_K562_Hela2.11099879
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07228872
18ELF1_20517297_ChIP-Seq_JURKAT_Human2.04683816
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.04023871
20FUS_26573619_Chip-Seq_HEK293_Human1.99350378
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94883181
22GATA1_26923725_Chip-Seq_HPCs_Mouse1.94246710
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93869484
24RAC3_21632823_ChIP-Seq_H3396_Human1.93211402
25DROSHA_22980978_ChIP-Seq_HELA_Human1.89291363
26KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.86899658
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84479027
28* ERA_21632823_ChIP-Seq_H3396_Human1.82303115
29NANOG_20526341_ChIP-Seq_ESCs_Human1.81719034
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81264446
31RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.79724927
32CTCF_27219007_Chip-Seq_Bcells_Human1.78835508
33EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.78159164
34ELK4_26923725_Chip-Seq_MESODERM_Mouse1.76864956
35STAT1_17558387_ChIP-Seq_HELA_Human1.73862888
36* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.72984531
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70200403
38MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.66700193
39FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65643663
40BCL6_27268052_Chip-Seq_Bcells_Human1.64080367
41TAF2_19829295_ChIP-Seq_ESCs_Human1.61164823
42SMC4_20622854_ChIP-Seq_HELA_Human1.59051605
43RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.58787296
44ARNT_22903824_ChIP-Seq_MCF-7_Human1.58001824
45E2F1_20622854_ChIP-Seq_HELA_Human1.56922287
46KAP1_22055183_ChIP-Seq_ESCs_Mouse1.56415418
47* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.55988707
48ER_23166858_ChIP-Seq_MCF-7_Human1.55277009
49SOX2_22085726_ChIP-Seq_NPCs_Mouse1.54549294
50KDM2B_26808549_Chip-Seq_REH_Human1.52769750
51* MYC_19829295_ChIP-Seq_ESCs_Human1.52419182
52GATA3_21867929_ChIP-Seq_CD8_Mouse1.51602898
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.51559707
54BCOR_27268052_Chip-Seq_Bcells_Human1.50852601
55TAL1_26923725_Chip-Seq_HPCs_Mouse1.50400125
56PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.49920173
57CTCF_20526341_ChIP-Seq_ESCs_Human1.48242115
58P68_20966046_ChIP-Seq_HELA_Human1.48137193
59OCT4_20526341_ChIP-Seq_ESCs_Human1.47493388
60PHF8_20622854_ChIP-Seq_HELA_Human1.47439703
61TP63_22573176_ChIP-Seq_HFKS_Human1.46023859
62* CBX2_27304074_Chip-Seq_ESCs_Mouse1.45481292
63* SMAD4_21741376_ChIP-Seq_EPCs_Human1.45063830
64TP53_18474530_ChIP-ChIP_U2OS_Human1.43200077
65HNFA_21074721_ChIP-Seq_CACO-2_Human1.42463901
66CBX2_22325352_ChIP-Seq_293T-Rex_Human1.41762571
67AR_25329375_ChIP-Seq_VCAP_Human1.41310657
68* WDR5_24793694_ChIP-Seq_LNCAP_Human1.41262375
69RBPJ_21746931_ChIP-Seq_IB4_Human1.38703348
70LXR_22292898_ChIP-Seq_THP-1_Human1.37558461
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.37550802
72CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.37211332
73* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36391284
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34911740
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.34673058
76ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33477396
77SMAD3_21741376_ChIP-Seq_ESCs_Human1.33392280
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32672298
79ETV1_20927104_ChIP-Seq_GIST48_Human1.32569865
80P300_27268052_Chip-Seq_Bcells_Human1.32246480
81* LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.31156351
82PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.30049054
83P53_21459846_ChIP-Seq_SAOS-2_Human1.29688517
84GATA3_21867929_ChIP-Seq_TH1_Mouse1.29305946
85FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.29248841
86SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.28700821
87SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28592600
88REST_21632747_ChIP-Seq_MESCs_Mouse1.28050079
89* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27830756
90* CBP_20019798_ChIP-Seq_JUKART_Human1.27830756
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27304252
92GATA3_21878914_ChIP-Seq_MCF-7_Human1.26369943
93* TDRD3_21172665_ChIP-Seq_MCF-7_Human1.26288772
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24857309
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24604547
96SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24382866
97P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.24112539
98* FLI1_21867929_ChIP-Seq_TH2_Mouse1.23956995
99KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.23261694
100CEBPB_22108803_ChIP-Seq_LS180_Human1.22836520
101TBL1_22424771_ChIP-Seq_293T_Human1.22168121
102GF1_26923725_Chip-Seq_HPCs_Mouse1.21515555
103* SMAD3_21741376_ChIP-Seq_EPCs_Human1.20851138
104CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20048013
105TP63_19390658_ChIP-ChIP_HaCaT_Human1.17983123
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17354898
107CRX_20693478_ChIP-Seq_RETINA_Mouse1.16902750
108PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16533835
109RUNX_20019798_ChIP-Seq_JUKART_Human1.15900043
110PHF8_20622853_ChIP-Seq_HELA_Human1.15568166
111CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14586267
112SMAD4_21741376_ChIP-Seq_HESCs_Human1.14247128
113RAD21_21589869_ChIP-Seq_MESCs_Mouse1.14149843
114SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14146504
115* P300_19829295_ChIP-Seq_ESCs_Human1.13920242
116RUNX1_26923725_Chip-Seq_HPCs_Mouse1.12399166
117GATA6_21074721_ChIP-Seq_CACO-2_Human1.11870309
118KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11058360
119NANOG_18555785_Chip-Seq_ESCs_Mouse1.10683790
120SA1_27219007_Chip-Seq_Bcells_Human1.10322819
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08925710
122SMRT_27268052_Chip-Seq_Bcells_Human1.08334245
123* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08049646
124TAF15_26573619_Chip-Seq_HEK293_Human1.08011470
125SPI1_26923725_Chip-Seq_HPCs_Mouse1.07890757
126NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07773221
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07145195
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07145195
129CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07100081
130ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06743002
131EZH2_27294783_Chip-Seq_ESCs_Mouse1.05781626
132SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04728556
133* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04540361
134NFYA_21822215_ChIP-Seq_K562_Human1.04267227
135NANOG_19829295_ChIP-Seq_ESCs_Human1.04251799
136SOX2_19829295_ChIP-Seq_ESCs_Human1.04251799
137PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.04163316
138OCT4_18555785_Chip-Seq_ESCs_Mouse1.04034441
139GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02636272
140OCT1_27270436_Chip-Seq_PROSTATE_Human1.01818556
141EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01587790
142* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00951118
143P53_22387025_ChIP-Seq_ESCs_Mouse1.00860564
144PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00743594
145EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00258823
146ESET_19884257_ChIP-Seq_ESCs_Mouse1.00196692
147ERG_20517297_ChIP-Seq_VCAP_Human1.00107096
148* RUNX2_22187159_ChIP-Seq_PCA_Human0.99201590
149RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98753154
150RNF2_27304074_Chip-Seq_NSC_Mouse0.98724644
151* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98570377
152RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98526616
153KLF5_25053715_ChIP-Seq_YYC3_Human0.98089022
154MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97975484
155MYC_27129775_Chip-Seq_CORNEA_Mouse0.97824066
156HOXB7_26014856_ChIP-Seq_BT474_Human0.97722657
157RARA_24833708_ChIP-Seq_LIVER_Mouse0.97128699
158CMYC_18555785_Chip-Seq_ESCs_Mouse0.97109982
159NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96565399
160OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96500788
161EZH2_27294783_Chip-Seq_NPCs_Mouse0.96331554
162GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95236977
163KLF4_18555785_Chip-Seq_ESCs_Mouse0.94571045
164LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94420889
165P300_18555785_Chip-Seq_ESCs_Mouse0.94079436
166YY1_22570637_ChIP-Seq_MALME-3M_Human0.91745167
167FLI1_21867929_ChIP-Seq_CD8_Mouse0.91351445
168NFYB_21822215_ChIP-Seq_K562_Human0.91304168
169SOX9_26525672_Chip-Seq_HEART_Mouse0.91087434
170ESRRB_18555785_Chip-Seq_ESCs_Mouse0.90941168
171GF1B_26923725_Chip-Seq_HPCs_Mouse0.90874932
172EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89418222
173JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.88997056
174STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88480223
175SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88425302
176PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88312756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.08722161
2MP0001929_abnormal_gametogenesis5.53719927
3MP0008877_abnormal_DNA_methylation4.28253123
4MP0002210_abnormal_sex_determination3.43345421
5MP0001348_abnormal_lacrimal_gland3.41060570
6MP0002161_abnormal_fertility/fecundity3.31206257
7MP0001145_abnormal_male_reproductive2.91301669
8MP0005670_abnormal_white_adipose2.84677392
9MP0002653_abnormal_ependyma_morphology2.64125756
10MP0000653_abnormal_sex_gland2.53029172
11MP0000678_abnormal_parathyroid_gland2.40971879
12MP0003718_maternal_effect2.23053100
13MP0005410_abnormal_fertilization16.4124013
14MP0002132_abnormal_respiratory_system1.94450452
15MP0005379_endocrine/exocrine_gland_phen1.68549813
16MP0001485_abnormal_pinna_reflex1.63154232
17MP0002160_abnormal_reproductive_system1.60613958
18MP0005623_abnormal_meninges_morphology1.59075080
19MP0001486_abnormal_startle_reflex1.51733087
20MP0004233_abnormal_muscle_weight1.51266478
21MP0002249_abnormal_larynx_morphology1.47050264
22MP0005310_abnormal_salivary_gland1.47045208
23MP0004510_myositis1.43962975
24MP0003646_muscle_fatigue1.37279240
25MP0009053_abnormal_anal_canal1.33537708
26MP0005451_abnormal_body_composition1.32511528
27MP0002282_abnormal_trachea_morphology1.30254430
28MP0004859_abnormal_synaptic_plasticity1.26350265
29MP0002822_catalepsy1.20192040
30MP0002138_abnormal_hepatobiliary_system1.20159433
31MP0001765_abnormal_ion_homeostasis1.13765101
32MP0001963_abnormal_hearing_physiology1.12617398
33MP0002735_abnormal_chemical_nociception1.10080861
34MP0001984_abnormal_olfaction1.07121716
35MP0002127_abnormal_cardiovascular_syste1.05375386
36MP0005647_abnormal_sex_gland1.01489198
37MP0005248_abnormal_Harderian_gland1.01423435
38MP0005395_other_phenotype1.00617783
39MP0000026_abnormal_inner_ear0.98508157
40MP0009046_muscle_twitch0.96752001
41MP0008058_abnormal_DNA_repair0.91117355
42MP0002234_abnormal_pharynx_morphology0.89682778
43MP0008995_early_reproductive_senescence0.89185990
44MP0000955_abnormal_spinal_cord0.83547487
45MP0005389_reproductive_system_phenotype0.80824002
46MP0008569_lethality_at_weaning0.76187470
47MP0005083_abnormal_biliary_tract0.75167490
48MP0000681_abnormal_thyroid_gland0.74525277
49MP0000049_abnormal_middle_ear0.73121538
50MP0002067_abnormal_sensory_capabilities0.72951978
51MP0003011_delayed_dark_adaptation0.71786463
52MP0003115_abnormal_respiratory_system0.70581447
53MP0004085_abnormal_heartbeat0.70524756
54MP0002733_abnormal_thermal_nociception0.69389574
55MP0005167_abnormal_blood-brain_barrier0.67193264
56MP0001905_abnormal_dopamine_level0.66203410
57MP0003878_abnormal_ear_physiology0.64446094
58MP0005377_hearing/vestibular/ear_phenot0.64446094
59MP0009697_abnormal_copulation0.64424121
60MP0002557_abnormal_social/conspecific_i0.63348973
61MP0001879_abnormal_lymphatic_vessel0.62694736
62MP0005636_abnormal_mineral_homeostasis0.60636582
63MP0005367_renal/urinary_system_phenotyp0.60233711
64MP0000516_abnormal_urinary_system0.60233711
65MP0005666_abnormal_adipose_tissue0.58872671
66MP0002572_abnormal_emotion/affect_behav0.56293708
67MP0010094_abnormal_chromosome_stability0.56164723
68MP0001666_abnormal_nutrient_absorption0.54825236
69MP0004484_altered_response_of0.52457319
70MP0001324_abnormal_eye_pigmentation0.52193534
71MP0002928_abnormal_bile_duct0.50098191
72MP0003077_abnormal_cell_cycle0.49877263
73MP0000003_abnormal_adipose_tissue0.49070656
74MP0002102_abnormal_ear_morphology0.48705084
75MP0000358_abnormal_cell_content/0.48636643
76MP0002269_muscular_atrophy0.48316272
77MP0004036_abnormal_muscle_relaxation0.48219376
78MP0002272_abnormal_nervous_system0.48059381
79MP0003699_abnormal_female_reproductive0.47583866
80MP0001440_abnormal_grooming_behavior0.47357115
81MP0003329_amyloid_beta_deposits0.47195366
82MP0001764_abnormal_homeostasis0.46889543
83MP0000569_abnormal_digit_pigmentation0.46659191
84MP0003137_abnormal_impulse_conducting0.46058177
85MP0001970_abnormal_pain_threshold0.45960878
86MP0002734_abnormal_mechanical_nocicepti0.43795768
87MP0009745_abnormal_behavioral_response0.43777705
88MP0001293_anophthalmia0.43377460
89MP0008057_abnormal_DNA_replication0.43030329
90MP0005551_abnormal_eye_electrophysiolog0.42753279
91MP0003950_abnormal_plasma_membrane0.40757167
92MP0005253_abnormal_eye_physiology0.40718144
93MP0000230_abnormal_systemic_arterial0.40383370
94MP0001545_abnormal_hematopoietic_system0.40280883
95MP0005397_hematopoietic_system_phenotyp0.40280883
96MP0001501_abnormal_sleep_pattern0.40277672
97MP0005408_hypopigmentation0.39648085
98MP0000249_abnormal_blood_vessel0.39320499
99MP0003119_abnormal_digestive_system0.39208640
100MP0000470_abnormal_stomach_morphology0.38714688
101MP0009115_abnormal_fat_cell0.38595767
102MP0003786_premature_aging0.36858707
103MP0003880_abnormal_central_pattern0.36840841
104MP0002736_abnormal_nociception_after0.35768702
105MP0002971_abnormal_brown_adipose0.35630355
106MP0005084_abnormal_gallbladder_morpholo0.35324198
107MP0009278_abnormal_bone_marrow0.35113332
108MP0004084_abnormal_cardiac_muscle0.34944126
109MP0001270_distended_abdomen0.34021624
110MP0006292_abnormal_olfactory_placode0.33531657
111MP0003936_abnormal_reproductive_system0.33391813
112MP0003635_abnormal_synaptic_transmissio0.32951264
113MP0006036_abnormal_mitochondrial_physio0.32718583
114MP0000534_abnormal_ureter_morphology0.31331564
115MP0003111_abnormal_nucleus_morphology0.30642876
116MP0001119_abnormal_female_reproductive0.30207208
117MP0003633_abnormal_nervous_system0.30153442
118MP0005391_vision/eye_phenotype0.30146393
119MP0002139_abnormal_hepatobiliary_system0.28103020
120MP0004019_abnormal_vitamin_homeostasis0.27660185
121MP0003942_abnormal_urinary_system0.25909063
122MP0001730_embryonic_growth_arrest0.25677523
123MP0004133_heterotaxia0.25447065
124MP0004811_abnormal_neuron_physiology0.25218186
125MP0010307_abnormal_tumor_latency0.24989105
126MP0003879_abnormal_hair_cell0.24913049
127MP0003861_abnormal_nervous_system0.23813096
128MP0008007_abnormal_cellular_replicative0.22681485
129MP0000604_amyloidosis0.22353104
130MP0003631_nervous_system_phenotype0.21993774
131MP0002152_abnormal_brain_morphology0.21777213
132MP0008961_abnormal_basal_metabolism0.21524991
133MP0003948_abnormal_gas_homeostasis0.20025233
134MP0001968_abnormal_touch/_nociception0.19294430
135MP0002169_no_abnormal_phenotype0.18793733
136MP0002873_normal_phenotype0.18553586
137MP0004808_abnormal_hematopoietic_stem0.18312508
138MP0002295_abnormal_pulmonary_circulatio0.18002070
139MP0006035_abnormal_mitochondrial_morpho0.17823364
140MP0001727_abnormal_embryo_implantation0.17026688
141MP0005375_adipose_tissue_phenotype0.17024223
142MP0004742_abnormal_vestibular_system0.16481238
143MP0001661_extended_life_span0.16229669
144MP0005423_abnormal_somatic_nervous0.15348500
145MP0000313_abnormal_cell_death0.15347604
146MP0003045_fibrosis0.14966436
147MP0008875_abnormal_xenobiotic_pharmacok0.14540862
148MP0001986_abnormal_taste_sensitivity0.14325034
149MP0002092_abnormal_eye_morphology0.14244786
150MP0005365_abnormal_bile_salt0.14084811
151MP0002084_abnormal_developmental_patter0.13942818
152MP0002229_neurodegeneration0.13387516
153MP0002405_respiratory_system_inflammati0.13020265
154MP0005319_abnormal_enzyme/_coenzyme0.12891057
155MP0000751_myopathy0.12876187
156MP0005535_abnormal_body_temperature0.12699112
157MP0004130_abnormal_muscle_cell0.12551560
158MP0002118_abnormal_lipid_homeostasis0.12531536
159MP0002796_impaired_skin_barrier0.12515361
160MP0003959_abnormal_lean_body0.12256771

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.40705202
2Abnormal respiratory motile cilium morphology (HP:0005938)9.38948755
3Abnormal respiratory epithelium morphology (HP:0012253)9.38948755
4Severe visual impairment (HP:0001141)8.33961287
5Rhinitis (HP:0012384)7.60410645
6Abnormal ciliary motility (HP:0012262)7.52862345
7Chronic bronchitis (HP:0004469)7.39219123
8Infertility (HP:0000789)6.77939093
9Nasal polyposis (HP:0100582)6.41662461
10Abnormality of the nasal mucosa (HP:0000433)5.27920522
11Bony spicule pigmentary retinopathy (HP:0007737)5.00607486
12Attenuation of retinal blood vessels (HP:0007843)4.99347459
13Chronic hepatic failure (HP:0100626)4.91062743
14Resting tremor (HP:0002322)4.74176651
15Bronchitis (HP:0012387)4.63988565
16Male infertility (HP:0003251)4.58547120
17Bronchiectasis (HP:0002110)4.46584830
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.41254779
19Hyperkalemia (HP:0002153)4.33028553
20Abnormality of macular pigmentation (HP:0008002)4.15681706
21Nephronophthisis (HP:0000090)4.05117387
22Cone-rod dystrophy (HP:0000548)3.96902310
23Abnormal rod and cone electroretinograms (HP:0008323)3.95182791
24Hypoplastic ischia (HP:0003175)3.92581424
25Facial shape deformation (HP:0011334)3.78469791
26Potter facies (HP:0002009)3.78469791
27Enlarged epiphyses (HP:0010580)3.76390976
28Aplasia/Hypoplasia of the earlobes (HP:0009906)3.63303387
29Abnormal spermatogenesis (HP:0008669)3.58342454
30Abnormality of the ischium (HP:0003174)3.51219834
31Recurrent sinusitis (HP:0011108)3.48085301
32Hypoplasia of the thymus (HP:0000778)3.34594318
33Recurrent otitis media (HP:0000403)3.31790051
34Progressive sensorineural hearing impairment (HP:0000408)3.22406324
35Hypoalphalipoproteinemia (HP:0003233)3.17142148
36Postural instability (HP:0002172)3.10824520
37Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.08727465
38Abnormality of the renal medulla (HP:0100957)3.05633870
39Unilateral renal agenesis (HP:0000122)2.83288218
40Recurrent bronchitis (HP:0002837)2.80501526
41Menstrual irregularities (HP:0000858)2.78002819
42Tubulointerstitial nephritis (HP:0001970)2.75497059
43Truncal obesity (HP:0001956)2.71696917
44Amelogenesis imperfecta (HP:0000705)2.70611637
45Impulsivity (HP:0100710)2.69595112
46Renovascular hypertension (HP:0100817)2.66910309
47Generalized aminoaciduria (HP:0002909)2.66746618
48Medial flaring of the eyebrow (HP:0010747)2.66606206
49Abnormality of dental color (HP:0011073)2.62575716
50Insulin-resistant diabetes mellitus (HP:0000831)2.62344136
51Progressive cerebellar ataxia (HP:0002073)2.60878699
52Portal hypertension (HP:0001409)2.60105178
53Abnormality of the aortic arch (HP:0012303)2.59499313
54Abnormality of midbrain morphology (HP:0002418)2.50378071
55Molar tooth sign on MRI (HP:0002419)2.50378071
56Abnormality of potassium homeostasis (HP:0011042)2.48642999
57Abnormality of the costochondral junction (HP:0000919)2.47948292
58Tubular atrophy (HP:0000092)2.43982326
59Gonadotropin excess (HP:0000837)2.42678762
60Abnormality of the hepatic vasculature (HP:0006707)2.38085950
61Azoospermia (HP:0000027)2.32584888
62Tubulointerstitial abnormality (HP:0001969)2.31144261
63Flattened epiphyses (HP:0003071)2.30902296
64Epiphyseal dysplasia (HP:0002656)2.25557610
65Ventricular tachycardia (HP:0004756)2.22446600
66Cholecystitis (HP:0001082)2.16695723
67Abnormal gallbladder physiology (HP:0012438)2.16695723
68Osteomalacia (HP:0002749)2.15497095
69Polyuria (HP:0000103)2.10400655
70Focal segmental glomerulosclerosis (HP:0000097)2.07095533
71Progressive hearing impairment (HP:0001730)2.06927870
72Abnormality of the parathyroid morphology (HP:0011766)2.05349909
73Abnormality of the epiphysis of the femoral head (HP:0010574)2.05185151
74Increased purine levels (HP:0004368)2.04845052
75Hyperuricemia (HP:0002149)2.04845052
76Recurrent pneumonia (HP:0006532)2.01787386
77Absent/shortened dynein arms (HP:0200106)13.6153182
78Dynein arm defect of respiratory motile cilia (HP:0012255)13.6153182
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2588302
80Hypophosphatemic rickets (HP:0004912)1.99155671
81Dyschromatopsia (HP:0007641)1.98193725
82Widely patent fontanelles and sutures (HP:0004492)1.98156971
83Hyponatremia (HP:0002902)1.96335130
84Abnormality of the pubic bones (HP:0003172)1.94163952
85Myokymia (HP:0002411)1.93330219
86Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.91986765
87Abnormality of femoral epiphyses (HP:0006499)1.91986765
88Spastic tetraparesis (HP:0001285)1.91656029
89Intellectual disability, moderate (HP:0002342)1.91105326
90Tubulointerstitial fibrosis (HP:0005576)1.82876375
91Abnormality of the femoral head (HP:0003368)1.81985129
92Optic nerve hypoplasia (HP:0000609)1.81861094
93Flat capital femoral epiphysis (HP:0003370)1.79357717
94Decreased central vision (HP:0007663)1.79294662
95Postaxial foot polydactyly (HP:0001830)1.79046938
96Bradycardia (HP:0001662)1.78640213
97Tetany (HP:0001281)1.77598442
98Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77126028
99Recurrent corneal erosions (HP:0000495)1.77035729
100Heterotopia (HP:0002282)1.76942699
101Renal Fanconi syndrome (HP:0001994)1.76706643
102Choroideremia (HP:0001139)1.73660421
103Stage 5 chronic kidney disease (HP:0003774)1.73073964
104Transposition of the great arteries (HP:0001669)1.72092271
105Abnormal connection of the cardiac segments (HP:0011545)1.72092271
106Abnormal ventriculo-arterial connection (HP:0011563)1.72092271
107Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69637613
108Congenital hepatic fibrosis (HP:0002612)1.65614702
109Congenital primary aphakia (HP:0007707)1.65599341
110Gait imbalance (HP:0002141)1.65237670
111Abnormal drinking behavior (HP:0030082)1.63396473
112Polydipsia (HP:0001959)1.63396473
113Abnormality of the renal cortex (HP:0011035)1.58972777
114Aplasia/Hypoplasia of the lens (HP:0008063)1.57523788
115Abnormality of renal excretion (HP:0011036)1.56156327
116Short ribs (HP:0000773)1.55906104
117Fibular hypoplasia (HP:0003038)1.55556387
118Chronic sinusitis (HP:0011109)1.54783831
119Abnormal biliary tract physiology (HP:0012439)1.52671328
120Bile duct proliferation (HP:0001408)1.52671328
121Abnormality of the lower motor neuron (HP:0002366)1.51140819
122Abnormality of permanent molar morphology (HP:0011071)1.50913550
123Abnormality of the dental root (HP:0006486)1.50913550
124Taurodontia (HP:0000679)1.50913550
125Hemorrhage of the eye (HP:0011885)1.50680700
126Bell-shaped thorax (HP:0001591)1.50209319
127Postaxial hand polydactyly (HP:0001162)1.48254933
128Oculomotor apraxia (HP:0000657)1.47815633
129Renal dysplasia (HP:0000110)1.46401121
130Abnormality of dentin (HP:0010299)1.41769759
131Facial cleft (HP:0002006)1.41126755
132Abnormality of molar (HP:0011077)1.40177492
133Abnormality of molar morphology (HP:0011070)1.40177492
134Nephrogenic diabetes insipidus (HP:0009806)1.39982768
135Abnormality of the dental pulp (HP:0006479)1.39067214
136Neurofibrillary tangles (HP:0002185)1.38279479
137Asymmetric septal hypertrophy (HP:0001670)1.37359708
138Decreased electroretinogram (ERG) amplitude (HP:0000654)1.33976146
139Cystic liver disease (HP:0006706)1.33511604
140Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.33175329
141Absent epiphyses (HP:0010577)1.33175329
142Absent frontal sinuses (HP:0002688)1.30562571
143Microglossia (HP:0000171)1.30366456
144Deformed sella turcica (HP:0002681)1.30288033
145Bundle branch block (HP:0011710)1.30018076
146Easy fatigability (HP:0003388)1.29723065
147Amyotrophic lateral sclerosis (HP:0007354)1.29534552
148Vaginal atresia (HP:0000148)1.27402963
149Cerebellar dysplasia (HP:0007033)1.26705248
150Genital tract atresia (HP:0001827)1.26226367
151Hemiparesis (HP:0001269)1.25279549
152Abnormal urine output (HP:0012590)1.24161962
153Poor coordination (HP:0002370)1.23906429
154Abnormality of saccadic eye movements (HP:0000570)1.23778611
155Pancreatic fibrosis (HP:0100732)1.22926456
156J-shaped sella turcica (HP:0002680)1.20844223
157Fatigable weakness (HP:0003473)1.19010911
158Abnormality of the neuromuscular junction (HP:0003398)1.19010911
159Abnormality of ocular smooth pursuit (HP:0000617)1.18680368
160Congenital malformation of the right heart (HP:0011723)1.18398413
161Double outlet right ventricle (HP:0001719)1.18398413
162Aplasia/Hypoplasia of the tongue (HP:0010295)1.18355291
163Supernumerary spleens (HP:0009799)1.17029375
164Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.16303312
165Cerebral inclusion bodies (HP:0100314)1.14662503
166Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.14268969

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.37012645
2PDK38.37012645
3TESK15.95263084
4PDK25.42103083
5PRKD35.17844100
6DDR24.96251746
7INSRR4.23808461
8ICK4.23739037
9MAP4K23.47415387
10BRD43.40139580
11PLK23.25380550
12PTK2B2.22187616
13WNK42.14440497
14STK392.04438844
15PNCK2.03524805
16PIK3CG1.93789260
17MST1R1.77484037
18STK381.70751197
19NEK21.56130688
20DYRK1B1.53651016
21CDK71.22591171
22PDK11.13213246
23KSR21.04412409
24MAP3K90.99483791
25TYRO30.91572407
26DYRK30.88416352
27AKT30.86366075
28CAMK1D0.85139434
29MAPK150.83096673
30WNK10.81104995
31IRAK10.79604394
32TESK20.74412077
33PASK0.73910588
34MAP3K110.71551893
35LATS20.69771878
36RPS6KA20.67515159
37CCNB10.67408421
38UHMK10.66762458
39PDPK10.65481286
40STK30.65378818
41SIK20.64687981
42CHEK20.60679851
43LMTK20.60012716
44MAP3K20.59962355
45RIPK40.59895112
46PRKAA20.58834496
47MAP2K60.58672029
48CAMK1G0.58231959
49MAP2K20.57537034
50TTK0.56636785
51CAMK10.54578489
52CDK30.53904295
53EEF2K0.53535265
54ROCK10.52605845
55MAP3K80.50133447
56LATS10.46733582
57PINK10.46502202
58PLK40.43265522
59SGK2230.42329932
60SGK4940.42329932
61TIE10.42130462
62STK38L0.41373548
63CHEK10.41042893
64PAK10.39466462
65MAPK10.39106371
66IRAK20.37394804
67MARK10.35497022
68NTRK20.35173648
69MAP3K10.34719325
70RPS6KC10.34605441
71RPS6KL10.34605441
72CAMK40.34575889
73ARAF0.33807253
74BMPR1B0.33581409
75WEE10.33254682
76MUSK0.31900474
77MET0.31314560
78RPS6KA60.31311323
79NTRK30.31197577
80PRKCG0.29513396
81ATM0.28485168
82PAK20.28233756
83CDK120.28220382
84MAP3K100.27212588
85MTOR0.26918519
86ATR0.26032147
87SGK10.24965634
88BRSK20.24691851
89MARK20.24240899
90MAPKAPK50.22495801
91CAMKK10.21945882
92NEK60.21366891
93PAK40.21316928
94MAPK140.20828339
95MAPK100.20650273
96CDC70.18514223
97PRKAA10.18457129
98MAPK110.17396765
99JAK30.16256764
100AKT10.15229110
101BLK0.14875592
102PLK10.14704993
103RPS6KB10.14483004
104PRKCZ0.13178119
105CDK150.11920751
106OXSR10.11866999
107BRSK10.11292083
108PRKCQ0.10882112
109TNIK0.10773767
110PKN10.09900967
111MARK30.09560917
112CDK180.09417777
113SGK20.08509228
114PRKG20.08370262
115CDK11A0.08156135
116PRKACA0.07353709
117RPS6KA10.06694837
118MAPK90.06670080
119CSNK1D0.06598921
120CSNK2A10.06563088
121RIPK10.06346886
122GSK3B0.05994686
123FER0.05969855
124PRKG10.05615210
125CDK140.05238488
126BRAF0.04861897
127MAP3K70.04647322
128CDK60.04582991
129PRKACG0.04242133
130STK100.03895802
131STK110.03585837
132CDK20.02915032
133YES10.02852564
134EGFR0.02703671
135CDK10.02510671
136CSNK2A20.02507577
137PDGFRB0.01892704
138CAMK2A0.01613827
139MAPK80.01457842
140ZAP700.01281733
141CSF1R0.00596214
142PRKCB0.00359748
143MAP3K5-0.0314675
144MAP3K4-0.0285702
145AURKA-0.0265959
146RPS6KA3-0.0261690
147PRKACB-0.0251000
148PRKDC-0.0202768
149PIM1-0.0172459
150WNK3-0.0070894
151CDK4-0.0060078
152PRKCA-0.0038986
153PRKCD-0.0018807

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.76723817
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.45560850
3Fatty acid biosynthesis_Homo sapiens_hsa000614.38538108
4Vitamin B6 metabolism_Homo sapiens_hsa007503.94369440
5Olfactory transduction_Homo sapiens_hsa047403.75769438
6Pyruvate metabolism_Homo sapiens_hsa006203.64984509
7Propanoate metabolism_Homo sapiens_hsa006402.94870314
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.89126261
9Linoleic acid metabolism_Homo sapiens_hsa005912.79599763
10Glucagon signaling pathway_Homo sapiens_hsa049222.63842670
11Butanoate metabolism_Homo sapiens_hsa006502.58489820
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.50923687
13Basal transcription factors_Homo sapiens_hsa030222.42514220
14Carbohydrate digestion and absorption_Homo sapiens_hsa049732.23571678
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.20608326
16Selenocompound metabolism_Homo sapiens_hsa004502.16583281
17Glycerolipid metabolism_Homo sapiens_hsa005612.06739009
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.97250685
19PPAR signaling pathway_Homo sapiens_hsa033201.97021795
20Pentose phosphate pathway_Homo sapiens_hsa000301.95464096
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.82584968
22Oocyte meiosis_Homo sapiens_hsa041141.73200905
23Type I diabetes mellitus_Homo sapiens_hsa049401.69890701
24Allograft rejection_Homo sapiens_hsa053301.65731193
25Phenylalanine metabolism_Homo sapiens_hsa003601.64815967
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.64024822
27Autoimmune thyroid disease_Homo sapiens_hsa053201.61666993
28Type II diabetes mellitus_Homo sapiens_hsa049301.60457530
29Fructose and mannose metabolism_Homo sapiens_hsa000511.59131423
30Dorso-ventral axis formation_Homo sapiens_hsa043201.58626987
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.57326442
32Graft-versus-host disease_Homo sapiens_hsa053321.50396066
33Amphetamine addiction_Homo sapiens_hsa050311.49367358
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.45611840
35Mineral absorption_Homo sapiens_hsa049781.43176888
36Carbon metabolism_Homo sapiens_hsa012001.41323574
37Fanconi anemia pathway_Homo sapiens_hsa034601.41212362
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35319188
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.34871180
40Fatty acid metabolism_Homo sapiens_hsa012121.33413370
41Fatty acid degradation_Homo sapiens_hsa000711.33007256
42Fat digestion and absorption_Homo sapiens_hsa049751.32058752
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.28788070
44Ether lipid metabolism_Homo sapiens_hsa005651.27692912
45Cardiac muscle contraction_Homo sapiens_hsa042601.25049057
46Viral myocarditis_Homo sapiens_hsa054161.19700952
47Arginine and proline metabolism_Homo sapiens_hsa003301.14367909
48Renin secretion_Homo sapiens_hsa049241.13011508
49Huntingtons disease_Homo sapiens_hsa050161.11637165
50Antigen processing and presentation_Homo sapiens_hsa046121.07339504
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04668848
52Arginine biosynthesis_Homo sapiens_hsa002201.02025676
53Phototransduction_Homo sapiens_hsa047441.01805818
54Purine metabolism_Homo sapiens_hsa002301.01355324
55mRNA surveillance pathway_Homo sapiens_hsa030150.99944232
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98200896
57RNA transport_Homo sapiens_hsa030130.92860669
58Biosynthesis of amino acids_Homo sapiens_hsa012300.92826981
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91436554
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90922235
61Collecting duct acid secretion_Homo sapiens_hsa049660.89887006
62Glutathione metabolism_Homo sapiens_hsa004800.89591911
63Morphine addiction_Homo sapiens_hsa050320.87088032
64Influenza A_Homo sapiens_hsa051640.82037933
65Chemical carcinogenesis_Homo sapiens_hsa052040.77995933
66Hedgehog signaling pathway_Homo sapiens_hsa043400.77221070
67Insulin secretion_Homo sapiens_hsa049110.75422797
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.75409482
69Long-term potentiation_Homo sapiens_hsa047200.72581689
70Nicotine addiction_Homo sapiens_hsa050330.71574671
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69635376
72Arachidonic acid metabolism_Homo sapiens_hsa005900.69273391
73Estrogen signaling pathway_Homo sapiens_hsa049150.69112215
74Bile secretion_Homo sapiens_hsa049760.68806899
75Tyrosine metabolism_Homo sapiens_hsa003500.68499135
76Renin-angiotensin system_Homo sapiens_hsa046140.67908790
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.66968097
78Thyroid hormone synthesis_Homo sapiens_hsa049180.66215070
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65399648
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64592764
81Glutamatergic synapse_Homo sapiens_hsa047240.60655918
82Retinol metabolism_Homo sapiens_hsa008300.57283860
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57115091
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.55740819
85Legionellosis_Homo sapiens_hsa051340.54950920
86Calcium signaling pathway_Homo sapiens_hsa040200.54174289
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53830972
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53830277
89ABC transporters_Homo sapiens_hsa020100.53037242
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.52409533
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48923438
92Protein digestion and absorption_Homo sapiens_hsa049740.48788984
93Synaptic vesicle cycle_Homo sapiens_hsa047210.48545272
94Systemic lupus erythematosus_Homo sapiens_hsa053220.48352962
95Inositol phosphate metabolism_Homo sapiens_hsa005620.48056028
96MAPK signaling pathway_Homo sapiens_hsa040100.46205045
97Pancreatic secretion_Homo sapiens_hsa049720.46177681
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45819246
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44701483
100Serotonergic synapse_Homo sapiens_hsa047260.43001273
101Endocytosis_Homo sapiens_hsa041440.42423048
102AMPK signaling pathway_Homo sapiens_hsa041520.42227036
103Salivary secretion_Homo sapiens_hsa049700.42004762
104Tight junction_Homo sapiens_hsa045300.40641963
105Metabolic pathways_Homo sapiens_hsa011000.39237572
106Cholinergic synapse_Homo sapiens_hsa047250.38994095
107Nitrogen metabolism_Homo sapiens_hsa009100.37788120
108Acute myeloid leukemia_Homo sapiens_hsa052210.37409623
109Taste transduction_Homo sapiens_hsa047420.37222435
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36772007
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36619731
112Gastric acid secretion_Homo sapiens_hsa049710.36462409
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.35412361
114VEGF signaling pathway_Homo sapiens_hsa043700.34772125
115N-Glycan biosynthesis_Homo sapiens_hsa005100.33889753
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31040960
117GABAergic synapse_Homo sapiens_hsa047270.30906226
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.29492773
119Sulfur metabolism_Homo sapiens_hsa009200.29110997
120Oxytocin signaling pathway_Homo sapiens_hsa049210.28790812
121ECM-receptor interaction_Homo sapiens_hsa045120.28504992
122cAMP signaling pathway_Homo sapiens_hsa040240.28432719
123Circadian entrainment_Homo sapiens_hsa047130.26131644
124Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25384542
125Pyrimidine metabolism_Homo sapiens_hsa002400.22922942
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22670965
127Prolactin signaling pathway_Homo sapiens_hsa049170.22405300
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20084099
129Herpes simplex infection_Homo sapiens_hsa051680.19464465
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18558896
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18553738
132Cocaine addiction_Homo sapiens_hsa050300.17765441
133Alcoholism_Homo sapiens_hsa050340.17566685
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14327677
135Steroid hormone biosynthesis_Homo sapiens_hsa001400.13704599
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13516010
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.13352345
138B cell receptor signaling pathway_Homo sapiens_hsa046620.10425638
139Wnt signaling pathway_Homo sapiens_hsa043100.09257259
140HIF-1 signaling pathway_Homo sapiens_hsa040660.05026149
141Basal cell carcinoma_Homo sapiens_hsa052170.04921687
142Viral carcinogenesis_Homo sapiens_hsa052030.04802876
143Salmonella infection_Homo sapiens_hsa051320.03133295

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