KIF3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.35664349
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.20869275
3synaptic vesicle exocytosis (GO:0016079)5.10952573
4vocalization behavior (GO:0071625)5.02510176
5pyrimidine nucleobase catabolic process (GO:0006208)4.90655228
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.83310963
7protein localization to synapse (GO:0035418)4.81466141
8regulation of synaptic vesicle exocytosis (GO:2000300)4.51685949
9synaptic vesicle maturation (GO:0016188)4.51557156
10glutamate secretion (GO:0014047)4.48262130
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.47254117
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.44610052
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.41305085
14regulation of glutamate receptor signaling pathway (GO:1900449)4.33187538
15locomotory exploration behavior (GO:0035641)4.20555948
16neuron recognition (GO:0008038)4.17349114
17neuronal action potential propagation (GO:0019227)4.12913959
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.12697201
19glutamate receptor signaling pathway (GO:0007215)4.07158641
20presynaptic membrane assembly (GO:0097105)4.06292705
21nucleobase catabolic process (GO:0046113)4.05474662
22synaptic transmission, glutamatergic (GO:0035249)4.04654664
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.02328148
24regulation of synaptic vesicle transport (GO:1902803)3.95382628
25postsynaptic membrane organization (GO:0001941)3.93603021
26neuron-neuron synaptic transmission (GO:0007270)3.92209595
27exploration behavior (GO:0035640)3.89014122
28neurotransmitter secretion (GO:0007269)3.87426782
29presynaptic membrane organization (GO:0097090)3.84279338
30axonal fasciculation (GO:0007413)3.79312062
31neurofilament cytoskeleton organization (GO:0060052)3.61578359
32regulation of neuronal synaptic plasticity (GO:0048168)3.60624294
33gamma-aminobutyric acid signaling pathway (GO:0007214)3.54284056
34transmission of nerve impulse (GO:0019226)3.52418637
35neurotransmitter-gated ion channel clustering (GO:0072578)3.48359430
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.48297469
37cell migration in hindbrain (GO:0021535)3.43491287
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.43466295
39regulation of long-term neuronal synaptic plasticity (GO:0048169)3.42863780
40layer formation in cerebral cortex (GO:0021819)3.39543734
41behavioral response to nicotine (GO:0035095)3.36627575
42regulation of excitatory postsynaptic membrane potential (GO:0060079)3.35386831
43negative regulation of synaptic transmission, GABAergic (GO:0032229)3.33894495
44neurotransmitter transport (GO:0006836)3.32439640
45gamma-aminobutyric acid transport (GO:0015812)3.32126502
46positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.30467840
47positive regulation of dendritic spine morphogenesis (GO:0061003)3.29684178
48proline transport (GO:0015824)3.29630005
49regulation of synapse structural plasticity (GO:0051823)3.29476115
50regulation of postsynaptic membrane potential (GO:0060078)3.27386260
51regulation of neurotransmitter secretion (GO:0046928)3.26549568
52cerebellar Purkinje cell differentiation (GO:0021702)3.26135578
53positive regulation of synapse maturation (GO:0090129)3.25480982
54G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.23803446
55positive regulation of synapse assembly (GO:0051965)3.21799941
56long-term memory (GO:0007616)3.19038230
57synaptic vesicle endocytosis (GO:0048488)3.17448974
58regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.14874617
59dendrite morphogenesis (GO:0048813)3.14759157
60regulation of vesicle fusion (GO:0031338)3.13495793
61dendritic spine morphogenesis (GO:0060997)3.13094150
62regulation of synaptic transmission, glutamatergic (GO:0051966)3.11561658
63synapse assembly (GO:0007416)3.11210595
64cerebellar granule cell differentiation (GO:0021707)3.10669216
65positive regulation of membrane potential (GO:0045838)3.08757737
66long-term synaptic potentiation (GO:0060291)3.08220665
67cellular potassium ion homeostasis (GO:0030007)3.07966403
68membrane depolarization during action potential (GO:0086010)3.05856169
69regulation of synaptic plasticity (GO:0048167)3.04703407
70regulation of glutamate secretion (GO:0014048)3.03659161
71startle response (GO:0001964)3.01941032
72regulation of neurotransmitter levels (GO:0001505)3.01589457
73innervation (GO:0060384)3.01512168
74central nervous system projection neuron axonogenesis (GO:0021952)3.01472003
75serotonin metabolic process (GO:0042428)3.01008217
76regulation of neurotransmitter transport (GO:0051588)3.00959101
77positive regulation of synaptic transmission, GABAergic (GO:0032230)3.00955482
78negative regulation of microtubule polymerization (GO:0031115)3.00472301
79negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98571380
80negative regulation of dendrite morphogenesis (GO:0050774)2.96265285
81membrane depolarization (GO:0051899)2.95410218
82neuronal ion channel clustering (GO:0045161)2.95263543
83behavioral fear response (GO:0001662)2.94967882
84behavioral defense response (GO:0002209)2.94967882
85neuromuscular synaptic transmission (GO:0007274)2.94226929
86regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.93402272
87response to histamine (GO:0034776)2.93287609
88dendrite development (GO:0016358)2.90410522
89adult walking behavior (GO:0007628)2.90198243
90positive regulation of neurotransmitter secretion (GO:0001956)2.89708886
91protein localization to cilium (GO:0061512)2.89661787
92glycosphingolipid biosynthetic process (GO:0006688)2.89090906
93positive regulation of neurotransmitter transport (GO:0051590)2.88875356
94negative regulation of neurotransmitter transport (GO:0051589)2.88730992
95membrane hyperpolarization (GO:0060081)2.88693324
96regulation of dendritic spine morphogenesis (GO:0061001)2.87609989
97neuronal action potential (GO:0019228)2.87135942
98auditory behavior (GO:0031223)2.86745622
99learning (GO:0007612)2.86568123
100fear response (GO:0042596)2.85799893
101synaptic transmission (GO:0007268)2.84882143
102positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.83550555
103regulation of respiratory system process (GO:0044065)2.82610710
104substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.79932698
105substrate-independent telencephalic tangential migration (GO:0021826)2.79932698
106establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.79481018
107mitochondrion transport along microtubule (GO:0047497)2.79481018
108activation of protein kinase A activity (GO:0034199)2.78765181
109establishment of mitochondrion localization (GO:0051654)2.78355838
110mechanosensory behavior (GO:0007638)2.78338748
111calcium ion-dependent exocytosis (GO:0017156)2.78167395
112regulation of protein kinase A signaling (GO:0010738)2.77900220
113cerebral cortex radially oriented cell migration (GO:0021799)2.77833659
114regulation of synaptic transmission (GO:0050804)2.76737954
115synapse organization (GO:0050808)2.76710509
116positive regulation of dendritic spine development (GO:0060999)2.76613454
117nonmotile primary cilium assembly (GO:0035058)2.76131943
118neuromuscular process controlling posture (GO:0050884)2.75647988
119response to auditory stimulus (GO:0010996)2.75517377
120mating behavior (GO:0007617)2.74738940
121retinal ganglion cell axon guidance (GO:0031290)2.74326490
122primary amino compound metabolic process (GO:1901160)2.72505333
123negative regulation of cytosolic calcium ion concentration (GO:0051481)2.67200916
124positive regulation of potassium ion transmembrane transport (GO:1901381)2.65970009
125adult behavior (GO:0030534)2.64402732
126regulation of synapse assembly (GO:0051963)2.63667178
127behavioral response to cocaine (GO:0048148)2.63632360
128retinal cone cell development (GO:0046549)2.61286429

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.26476744
2GBX2_23144817_ChIP-Seq_PC3_Human3.92879247
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02837011
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95935628
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87741918
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57982353
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57982353
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.55738850
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50892034
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50435683
11REST_21632747_ChIP-Seq_MESCs_Mouse2.50215240
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45380992
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41831429
14TAF15_26573619_Chip-Seq_HEK293_Human2.39620535
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.32512905
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29713511
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29401084
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.22543639
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13574529
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.10343453
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.06970974
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06823741
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05825353
24REST_18959480_ChIP-ChIP_MESCs_Mouse1.98460596
25RARB_27405468_Chip-Seq_BRAIN_Mouse1.96062775
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95473149
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94915670
28DROSHA_22980978_ChIP-Seq_HELA_Human1.92633012
29AR_21572438_ChIP-Seq_LNCaP_Human1.92110490
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90997511
31* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89835952
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82647414
33SMAD4_21799915_ChIP-Seq_A2780_Human1.76010422
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75066262
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.69643433
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66790054
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65823356
38P300_19829295_ChIP-Seq_ESCs_Human1.65377381
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63948579
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55419698
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54500314
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51672478
43EWS_26573619_Chip-Seq_HEK293_Human1.51410097
44RNF2_27304074_Chip-Seq_NSC_Mouse1.50447568
45ZNF274_21170338_ChIP-Seq_K562_Hela1.49215980
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47495731
47IGF1R_20145208_ChIP-Seq_DFB_Human1.47485804
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46463427
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.46196384
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.45856763
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44978656
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44423911
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44029663
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41831036
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40636654
56VDR_22108803_ChIP-Seq_LS180_Human1.38651249
57FUS_26573619_Chip-Seq_HEK293_Human1.37528198
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.35122292
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.30989581
60AR_25329375_ChIP-Seq_VCAP_Human1.30964125
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30143837
62STAT3_23295773_ChIP-Seq_U87_Human1.26582080
63CBP_20019798_ChIP-Seq_JUKART_Human1.24243093
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24243093
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20502517
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19778543
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.19430307
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17885688
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.17424876
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17400978
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.17117906
72RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16700405
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16196910
74ER_23166858_ChIP-Seq_MCF-7_Human1.15705597
75* TCF4_23295773_ChIP-Seq_U87_Human1.15242349
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.14433753
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13881328
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13061803
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.12929121
80BCAT_22108803_ChIP-Seq_LS180_Human1.12491706
81AHR_22903824_ChIP-Seq_MCF-7_Human1.11447512
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10002648
83* RUNX2_22187159_ChIP-Seq_PCA_Human1.08938772
84EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08539735
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08199043
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07890991
87TAL1_26923725_Chip-Seq_HPCs_Mouse1.06699969
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06664010
89JUN_21703547_ChIP-Seq_K562_Human1.06231099
90AR_19668381_ChIP-Seq_PC3_Human1.05888677
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05590916
92P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05265390
93* PRDM14_20953172_ChIP-Seq_ESCs_Human1.05016958
94RING1B_27294783_Chip-Seq_NPCs_Mouse1.03903808
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03341734
96RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02626107
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02614394
98NANOG_18555785_Chip-Seq_ESCs_Mouse0.99999582
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99584333
100* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99557860
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99455822
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99455822
103NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98911441
104FLI1_21867929_ChIP-Seq_TH2_Mouse0.97489957
105ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97133115
106P53_22387025_ChIP-Seq_ESCs_Mouse0.96717836
107TP53_18474530_ChIP-ChIP_U2OS_Human0.94818183
108SMAD3_21741376_ChIP-Seq_ESCs_Human0.93453055
109WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92757323
110SOX9_26525672_Chip-Seq_HEART_Mouse0.89804442
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89471315
112KDM2B_26808549_Chip-Seq_REH_Human0.89180321
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87750364
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87142764
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86716078
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86571093
117E2F1_18555785_Chip-Seq_ESCs_Mouse0.86306749

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.03380580
2MP0003880_abnormal_central_pattern4.99732753
3MP0003635_abnormal_synaptic_transmissio3.65350535
4MP0004270_analgesia3.56943624
5MP0001968_abnormal_touch/_nociception3.27344716
6MP0009745_abnormal_behavioral_response3.10120590
7MP0009046_muscle_twitch2.99890769
8MP0002063_abnormal_learning/memory/cond2.97659901
9MP0002064_seizures2.93661440
10MP0002735_abnormal_chemical_nociception2.90657091
11MP0002736_abnormal_nociception_after2.77995659
12MP0002734_abnormal_mechanical_nocicepti2.74491854
13MP0002572_abnormal_emotion/affect_behav2.66388590
14MP0005423_abnormal_somatic_nervous2.65847689
15MP0006276_abnormal_autonomic_nervous2.57896640
16MP0002272_abnormal_nervous_system2.57762929
17MP0001486_abnormal_startle_reflex2.35149513
18MP0001440_abnormal_grooming_behavior2.23346310
19MP0002733_abnormal_thermal_nociception2.18998692
20MP0002822_catalepsy2.16505323
21* MP0000778_abnormal_nervous_system2.16003993
22MP0002067_abnormal_sensory_capabilities2.11831636
23MP0001970_abnormal_pain_threshold2.07286044
24MP0002184_abnormal_innervation2.06146630
25MP0001501_abnormal_sleep_pattern1.91372266
26MP0003122_maternal_imprinting1.78543535
27MP0002557_abnormal_social/conspecific_i1.75408325
28MP0001529_abnormal_vocalization1.75142928
29MP0005386_behavior/neurological_phenoty1.70828336
30MP0004924_abnormal_behavior1.70828336
31MP0003787_abnormal_imprinting1.68751363
32MP0008569_lethality_at_weaning1.67319804
33MP0001984_abnormal_olfaction1.65189569
34MP0004858_abnormal_nervous_system1.64872300
35MP0004811_abnormal_neuron_physiology1.61823695
36MP0005645_abnormal_hypothalamus_physiol1.61683625
37MP0004142_abnormal_muscle_tone1.58955191
38* MP0000955_abnormal_spinal_cord1.58484549
39MP0005646_abnormal_pituitary_gland1.55726814
40MP0002882_abnormal_neuron_morphology1.54649334
41MP0009780_abnormal_chondrocyte_physiolo1.53475180
42MP0001188_hyperpigmentation1.53273219
43MP0003329_amyloid_beta_deposits1.51533233
44MP0001905_abnormal_dopamine_level1.50719809
45MP0006292_abnormal_olfactory_placode1.44496043
46MP0002066_abnormal_motor_capabilities/c1.39276312
47MP0004742_abnormal_vestibular_system1.26604759
48MP0003123_paternal_imprinting1.23460700
49MP0001502_abnormal_circadian_rhythm1.21873794
50MP0008789_abnormal_olfactory_epithelium1.19744298
51MP0004885_abnormal_endolymph1.19003447
52MP0000751_myopathy1.18571188
53MP0003879_abnormal_hair_cell1.18422826
54* MP0002152_abnormal_brain_morphology1.16177182
55MP0000566_synostosis1.14540457
56MP0005187_abnormal_penis_morphology1.13139118
57MP0003890_abnormal_embryonic-extraembry1.10225324
58MP0002229_neurodegeneration1.10175856
59MP0003633_abnormal_nervous_system1.08004758
60MP0002234_abnormal_pharynx_morphology1.06749121
61MP0002909_abnormal_adrenal_gland1.06329569
62MP0005551_abnormal_eye_electrophysiolog1.04720049
63MP0002752_abnormal_somatic_nervous1.04115287
64MP0001963_abnormal_hearing_physiology1.02772606
65MP0003631_nervous_system_phenotype1.00559116
66MP0000631_abnormal_neuroendocrine_gland1.00524666
67MP0005171_absent_coat_pigmentation1.00292490
68MP0003634_abnormal_glial_cell0.99349877
69MP0004145_abnormal_muscle_electrophysio0.98386314
70* MP0004133_heterotaxia0.96052598
71MP0005499_abnormal_olfactory_system0.90876583
72MP0005394_taste/olfaction_phenotype0.90876583
73MP0002751_abnormal_autonomic_nervous0.90844053
74MP0002837_dystrophic_cardiac_calcinosis0.90803498
75MP0000920_abnormal_myelination0.89254575
76MP0003119_abnormal_digestive_system0.87059824
77MP0002638_abnormal_pupillary_reflex0.86567257
78MP0002102_abnormal_ear_morphology0.86336966
79MP0003938_abnormal_ear_development0.85728792
80MP0002069_abnormal_eating/drinking_beha0.85343285
81MP0002876_abnormal_thyroid_physiology0.85045088
82MP0005409_darkened_coat_color0.84908152
83MP0004043_abnormal_pH_regulation0.84286655
84MP0004085_abnormal_heartbeat0.83998822
85MP0010386_abnormal_urinary_bladder0.83706048
86MP0003121_genomic_imprinting0.82249449
87MP0003632_abnormal_nervous_system0.79821060
88MP0002928_abnormal_bile_duct0.78415749
89MP0001485_abnormal_pinna_reflex0.77751740
90MP0000026_abnormal_inner_ear0.77456396
91MP0001177_atelectasis0.77317747
92MP0005195_abnormal_posterior_eye0.76596785
93MP0005623_abnormal_meninges_morphology0.74849910
94* MP0003861_abnormal_nervous_system0.73948998
95MP0004215_abnormal_myocardial_fiber0.72732112
96MP0006072_abnormal_retinal_apoptosis0.72194473
97MP0000427_abnormal_hair_cycle0.68678493
98MP0008877_abnormal_DNA_methylation0.68596020
99MP0003137_abnormal_impulse_conducting0.68325095
100MP0002160_abnormal_reproductive_system0.68114041
101MP0005410_abnormal_fertilization0.67748153
102MP0003283_abnormal_digestive_organ0.67672647
103MP0008872_abnormal_physiological_respon0.67087188
104MP0001943_abnormal_respiration0.65510131
105MP0003698_abnormal_male_reproductive0.64992174
106MP0008874_decreased_physiological_sensi0.64077251
107MP0000049_abnormal_middle_ear0.63308601
108MP0002938_white_spotting0.62928121
109MP0001664_abnormal_digestion0.61173898
110MP0001986_abnormal_taste_sensitivity0.60847862
111MP0002653_abnormal_ependyma_morphology0.60827021
112MP0000569_abnormal_digit_pigmentation0.59334701
113MP0005253_abnormal_eye_physiology0.58559389
114MP0004484_altered_response_of0.56947665
115MP0010770_preweaning_lethality0.56340237
116MP0002082_postnatal_lethality0.56340237
117MP0010769_abnormal_survival0.55575296
118MP0002090_abnormal_vision0.55215830
119MP0005535_abnormal_body_temperature0.54551894

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.55562327
2Myokymia (HP:0002411)5.90851499
3Focal seizures (HP:0007359)4.87120646
4Atonic seizures (HP:0010819)4.65891166
5Progressive cerebellar ataxia (HP:0002073)4.45921923
6Epileptic encephalopathy (HP:0200134)4.43979020
7Febrile seizures (HP:0002373)4.27858710
8Visual hallucinations (HP:0002367)4.05037654
9Absence seizures (HP:0002121)3.57782587
10Hyperventilation (HP:0002883)3.34594187
11Dialeptic seizures (HP:0011146)3.34346047
12Supranuclear gaze palsy (HP:0000605)3.32673204
13Action tremor (HP:0002345)3.30633275
14Generalized tonic-clonic seizures (HP:0002069)3.27548303
15Broad-based gait (HP:0002136)3.26659274
16Ankle clonus (HP:0011448)3.11454506
17Limb dystonia (HP:0002451)3.06618596
18Abnormality of the corticospinal tract (HP:0002492)3.02102410
19Insidious onset (HP:0003587)3.02018465
20Termporal pattern (HP:0011008)3.02018465
21Gaze-evoked nystagmus (HP:0000640)2.97596158
22Pheochromocytoma (HP:0002666)2.95186289
23Molar tooth sign on MRI (HP:0002419)2.87253000
24Abnormality of midbrain morphology (HP:0002418)2.87253000
25Urinary bladder sphincter dysfunction (HP:0002839)2.81631271
26Gait imbalance (HP:0002141)2.80380944
27Pancreatic fibrosis (HP:0100732)2.78934920
28Truncal ataxia (HP:0002078)2.78810183
29Nephronophthisis (HP:0000090)2.75973052
30Impaired vibration sensation in the lower limbs (HP:0002166)2.75730419
31Amblyopia (HP:0000646)2.74555392
32Neuroendocrine neoplasm (HP:0100634)2.68370374
33Drooling (HP:0002307)2.67690535
34Excessive salivation (HP:0003781)2.67690535
35Degeneration of the lateral corticospinal tracts (HP:0002314)2.66184329
36Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.66184329
37True hermaphroditism (HP:0010459)2.66031341
38Polyphagia (HP:0002591)2.60707852
39Dysdiadochokinesis (HP:0002075)2.60182489
40Abnormal eating behavior (HP:0100738)2.58326183
41Spastic gait (HP:0002064)2.55930989
42Pancreatic cysts (HP:0001737)2.54409729
43Dysmetria (HP:0001310)2.53815175
44Progressive inability to walk (HP:0002505)2.48696608
45Abnormal hair whorl (HP:0010721)2.48114554
46Anxiety (HP:0000739)2.47642447
47Mutism (HP:0002300)2.45147138
48Neurofibrillary tangles (HP:0002185)2.44860903
49Lissencephaly (HP:0001339)2.42333402
50Urinary urgency (HP:0000012)2.41770327
51Genetic anticipation (HP:0003743)2.40614668
52Depression (HP:0000716)2.38813893
53Fetal akinesia sequence (HP:0001989)2.37940291
54Medial flaring of the eyebrow (HP:0010747)2.36171622
55Cerebral inclusion bodies (HP:0100314)2.33592060
56Absent speech (HP:0001344)2.33317824
57Congenital primary aphakia (HP:0007707)2.32764157
58Epileptiform EEG discharges (HP:0011182)2.31867935
59Scanning speech (HP:0002168)2.28793364
60Specific learning disability (HP:0001328)2.27671611
61Poor eye contact (HP:0000817)2.27478853
62Spastic tetraplegia (HP:0002510)2.22959017
63Status epilepticus (HP:0002133)2.22857463
64Genital tract atresia (HP:0001827)2.22359240
65Diplopia (HP:0000651)2.21127362
66Abnormality of binocular vision (HP:0011514)2.21127362
67Poor coordination (HP:0002370)2.20811002
68Nephrogenic diabetes insipidus (HP:0009806)2.20473175
69Lower limb muscle weakness (HP:0007340)2.20153254
70EEG with generalized epileptiform discharges (HP:0011198)2.18241379
71Abnormality of the renal medulla (HP:0100957)2.16578004
72Pachygyria (HP:0001302)2.15662237
73Vaginal atresia (HP:0000148)2.14839884
74Ulnar claw (HP:0001178)2.14400864
75Dynein arm defect of respiratory motile cilia (HP:0012255)2.14161328
76Absent/shortened dynein arms (HP:0200106)2.14161328
77Abnormality of the lower motor neuron (HP:0002366)2.13290319
78Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.11268849
79Akinesia (HP:0002304)2.11002446
80Hemiparesis (HP:0001269)2.09047132
81Inability to walk (HP:0002540)2.08691194
82Hypsarrhythmia (HP:0002521)2.07157732
83Abnormal ciliary motility (HP:0012262)2.06906529
84Failure to thrive in infancy (HP:0001531)2.04308200
85Abnormal social behavior (HP:0012433)2.03396069
86Impaired social interactions (HP:0000735)2.03396069
87Type II lissencephaly (HP:0007260)2.03290236
88Retinal dysplasia (HP:0007973)2.02004948
89Morphological abnormality of the pyramidal tract (HP:0002062)2.00886835
90Optic nerve hypoplasia (HP:0000609)1.99853677
91Agitation (HP:0000713)1.99737515
92Impaired smooth pursuit (HP:0007772)1.99108072
93Aplasia/Hypoplasia of the brainstem (HP:0007362)1.98570324
94Hypoplasia of the brainstem (HP:0002365)1.98570324
95Oligodactyly (hands) (HP:0001180)1.96467345
96Protruding tongue (HP:0010808)1.96143576
97Blue irides (HP:0000635)1.94444329
98Amyotrophic lateral sclerosis (HP:0007354)1.90854942
99Sleep apnea (HP:0010535)1.90128179
100Abnormal respiratory motile cilium physiology (HP:0012261)1.89292257
101Cystic liver disease (HP:0006706)1.88943485
102Hypoventilation (HP:0002791)1.87360592
103Esotropia (HP:0000565)1.86407295
104Postaxial hand polydactyly (HP:0001162)1.86253884
105Bradykinesia (HP:0002067)1.85927979
106Abnormality of salivation (HP:0100755)1.84157812
107Impaired vibratory sensation (HP:0002495)1.83245721
108Postural instability (HP:0002172)1.83165334
109Narrow nasal bridge (HP:0000446)1.82714511
110Generalized myoclonic seizures (HP:0002123)1.80550734
111Torticollis (HP:0000473)1.79821177
112Abnormal respiratory motile cilium morphology (HP:0005938)1.79514174
113Abnormal respiratory epithelium morphology (HP:0012253)1.79514174
114Poor suck (HP:0002033)1.78811204
115Chronic hepatic failure (HP:0100626)1.78474254
116Abnormality of the labia minora (HP:0012880)1.77280130
117Stereotypic behavior (HP:0000733)1.76432321
118Focal dystonia (HP:0004373)1.75213627
119Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.75030423
120Hypothermia (HP:0002045)1.75021927
121Congenital stationary night blindness (HP:0007642)1.71703228
122Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71420196
123Sclerocornea (HP:0000647)1.69978730
124Narrow forehead (HP:0000341)1.69516911
125Hypoplasia of the corpus callosum (HP:0002079)1.69426510
126Volvulus (HP:0002580)1.69149539
127Exotropia (HP:0000577)1.66796212
128Postaxial foot polydactyly (HP:0001830)1.66243458
129Muscular hypotonia of the trunk (HP:0008936)1.66199323
130Intellectual disability, severe (HP:0010864)1.63148302
131Hepatoblastoma (HP:0002884)1.62484912
132Intention tremor (HP:0002080)1.59477181

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.20404461
2NTRK34.14688461
3MARK13.71221242
4EPHA43.08551016
5MAP3K43.01161548
6MAP3K92.91522399
7MAP2K72.75777480
8MINK12.63433687
9FRK2.46965476
10MAP3K122.39271732
11PNCK2.23203113
12MAPK132.09299621
13NTRK22.08592744
14PLK21.89720591
15DAPK21.89542996
16PINK11.86428142
17CDK191.73944133
18MAP2K41.71372099
19NTRK11.64268615
20TNIK1.52697648
21PAK61.51322007
22TRIM281.48741925
23MAP4K21.44037153
24GRK51.41186940
25CDK51.37975861
26OXSR11.35318218
27PHKG11.33074447
28PHKG21.33074447
29UHMK11.31023999
30KSR11.26814923
31PRKCG1.22340958
32DAPK11.22017370
33SGK2231.21794151
34SGK4941.21794151
35ARAF1.20030439
36PRPF4B1.16768099
37KSR21.12050151
38* CAMK2A1.10719064
39CAMK2B1.10240392
40CSNK1G21.09463693
41SIK21.06855310
42BCR1.05966469
43RIPK41.04189597
44STK391.00190515
45FES0.97689484
46LATS20.96960436
47AKT30.94182067
48CDK140.94041210
49CAMKK10.93417265
50CDK180.93331888
51CDK150.88150652
52SGK20.88145788
53DYRK20.85780712
54LIMK10.85556972
55GRK70.85349660
56DYRK1A0.84350795
57BMPR20.80743660
58SIK30.80399300
59GRK10.79484476
60PRKD30.79389410
61PRKCE0.78865038
62CDK11A0.77719009
63CSNK1G30.77401640
64MKNK20.77169118
65PAK30.76481960
66CAMKK20.74267309
67FGFR20.73951086
68CAMK2D0.72600331
69MARK20.72408646
70PTK2B0.72041883
71INSRR0.71811048
72MAPKAPK50.69791089
73WNK30.69669541
74FER0.68913388
75PKN10.67731433
76TYRO30.65438575
77NME10.64009059
78ERBB30.63961916
79DYRK30.63705340
80CAMK2G0.60312035
81MAP3K20.59303877
82CAMK10.59226997
83ROCK20.58474667
84STK380.58378277
85FGR0.57963530
86STK110.56642006
87SGK10.56637438
88ADRBK10.56326777
89CAMK40.56216991
90LMTK20.55166731
91RET0.55064595
92CSNK1E0.54478846
93BRAF0.54470798
94CSNK1A1L0.54413436
95WNK10.52729782
96PRKACA0.50327074
97RPS6KA20.49458340
98SGK30.48760581
99TNK20.48428764
100BMPR1B0.48090728
101PRKG10.47931934
102CSNK1D0.47654683
103WNK40.46212515
104MAPK150.46012643
105CSNK1A10.45538082
106MAP3K60.45297118
107CAMK1G0.45248475
108NUAK10.43889227
109PRKCH0.43292193
110PRKCZ0.43057317
111CDK30.42149203
112ADRBK20.42132417
113EPHA30.40957205
114CSNK1G10.39343123
115MAPK100.38988633
116CCNB10.38781190
117NEK60.38668843
118PDK40.38075673
119PDK30.38075673
120RPS6KA30.37766037
121PRKACB0.37689819
122TAOK10.36079434
123PRKAA10.31742816
124PRKDC0.30698595
125EPHB20.30268047
126STK38L0.28417613
127GSK3B0.27300814
128RPS6KA40.27066080

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.04431573
2Synaptic vesicle cycle_Homo sapiens_hsa047213.52350900
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75824173
4GABAergic synapse_Homo sapiens_hsa047272.61979933
5Olfactory transduction_Homo sapiens_hsa047402.57828790
6Circadian entrainment_Homo sapiens_hsa047132.57254616
7Glutamatergic synapse_Homo sapiens_hsa047242.49574562
8Morphine addiction_Homo sapiens_hsa050322.46637380
9Long-term potentiation_Homo sapiens_hsa047202.44758001
10Amphetamine addiction_Homo sapiens_hsa050312.37569426
11Collecting duct acid secretion_Homo sapiens_hsa049662.26826271
12Dopaminergic synapse_Homo sapiens_hsa047282.22420320
13Taste transduction_Homo sapiens_hsa047422.10780997
14Serotonergic synapse_Homo sapiens_hsa047261.95163841
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.93592439
16Salivary secretion_Homo sapiens_hsa049701.88807630
17Long-term depression_Homo sapiens_hsa047301.82018573
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.81589253
19Cholinergic synapse_Homo sapiens_hsa047251.81334860
20Insulin secretion_Homo sapiens_hsa049111.74302727
21Cocaine addiction_Homo sapiens_hsa050301.63964068
22Renin secretion_Homo sapiens_hsa049241.62952711
23Gastric acid secretion_Homo sapiens_hsa049711.59452265
24Oxidative phosphorylation_Homo sapiens_hsa001901.58787232
25Axon guidance_Homo sapiens_hsa043601.50907229
26Vibrio cholerae infection_Homo sapiens_hsa051101.50874373
27Calcium signaling pathway_Homo sapiens_hsa040201.49993781
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47378780
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45822451
30Oxytocin signaling pathway_Homo sapiens_hsa049211.45114541
31Protein export_Homo sapiens_hsa030601.42384506
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39773178
33Phototransduction_Homo sapiens_hsa047441.39575905
34Butanoate metabolism_Homo sapiens_hsa006501.35993500
35Gap junction_Homo sapiens_hsa045401.33033240
36Cardiac muscle contraction_Homo sapiens_hsa042601.32149632
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25241519
38Alzheimers disease_Homo sapiens_hsa050101.24992336
39GnRH signaling pathway_Homo sapiens_hsa049121.24210662
40Parkinsons disease_Homo sapiens_hsa050121.21368191
41cAMP signaling pathway_Homo sapiens_hsa040241.12152037
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11626050
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10990593
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04358380
45Melanogenesis_Homo sapiens_hsa049161.03318475
46Estrogen signaling pathway_Homo sapiens_hsa049151.02220158
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.99674137
48ErbB signaling pathway_Homo sapiens_hsa040120.97371829
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95886830
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90435153
51Huntingtons disease_Homo sapiens_hsa050160.89811298
52Glioma_Homo sapiens_hsa052140.89630020
53Oocyte meiosis_Homo sapiens_hsa041140.89626464
54Steroid biosynthesis_Homo sapiens_hsa001000.87818311
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.87738937
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86131240
57Type II diabetes mellitus_Homo sapiens_hsa049300.83111055
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82527275
59Dorso-ventral axis formation_Homo sapiens_hsa043200.80705803
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79586722
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78127036
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78047374
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72622182
64Regulation of autophagy_Homo sapiens_hsa041400.69539005
65Dilated cardiomyopathy_Homo sapiens_hsa054140.68144018
66Basal transcription factors_Homo sapiens_hsa030220.67521285
67Pancreatic secretion_Homo sapiens_hsa049720.67372750
68MAPK signaling pathway_Homo sapiens_hsa040100.66378374
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65925819
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65604645
71Linoleic acid metabolism_Homo sapiens_hsa005910.64830295
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.64570609
73Hippo signaling pathway_Homo sapiens_hsa043900.63934011
74Nitrogen metabolism_Homo sapiens_hsa009100.63182923
75Ras signaling pathway_Homo sapiens_hsa040140.62863500
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62832614
77Caffeine metabolism_Homo sapiens_hsa002320.61444815
78Alcoholism_Homo sapiens_hsa050340.60517679
79Choline metabolism in cancer_Homo sapiens_hsa052310.58360526
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58168025
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57973331
82Wnt signaling pathway_Homo sapiens_hsa043100.56546275
83Thyroid hormone synthesis_Homo sapiens_hsa049180.56211504
84Rheumatoid arthritis_Homo sapiens_hsa053230.55640702
85Phagosome_Homo sapiens_hsa041450.55605898
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48786735
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.48737597
88Hedgehog signaling pathway_Homo sapiens_hsa043400.48377497
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.48150230
90beta-Alanine metabolism_Homo sapiens_hsa004100.45340715
91Renal cell carcinoma_Homo sapiens_hsa052110.44622147
92Fatty acid biosynthesis_Homo sapiens_hsa000610.44196325
93Rap1 signaling pathway_Homo sapiens_hsa040150.43719753
94Ovarian steroidogenesis_Homo sapiens_hsa049130.43649269
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43346123
96Selenocompound metabolism_Homo sapiens_hsa004500.43340324
97Glucagon signaling pathway_Homo sapiens_hsa049220.42945391
98Propanoate metabolism_Homo sapiens_hsa006400.42703880
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41949166
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41584872
101Endocytosis_Homo sapiens_hsa041440.40899588
102Basal cell carcinoma_Homo sapiens_hsa052170.40207934
103Tryptophan metabolism_Homo sapiens_hsa003800.39248528
104Circadian rhythm_Homo sapiens_hsa047100.39125224
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38525055
106Ether lipid metabolism_Homo sapiens_hsa005650.38400579
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36947443
108Bile secretion_Homo sapiens_hsa049760.36540245
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35489375
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35472470
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35353433
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34905737
113Vitamin B6 metabolism_Homo sapiens_hsa007500.34173616
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33706411
115Endometrial cancer_Homo sapiens_hsa052130.33436183
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32897095
117Prion diseases_Homo sapiens_hsa050200.32324820
118VEGF signaling pathway_Homo sapiens_hsa043700.32118857
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31783097
120Melanoma_Homo sapiens_hsa052180.31428273
121RNA degradation_Homo sapiens_hsa030180.31180345
122Type I diabetes mellitus_Homo sapiens_hsa049400.30744729
123Inositol phosphate metabolism_Homo sapiens_hsa005620.30527844
124Colorectal cancer_Homo sapiens_hsa052100.29557670
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29029297
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28522936

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »