KIF3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.98086221
2locomotory exploration behavior (GO:0035641)4.86078321
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.76654845
4layer formation in cerebral cortex (GO:0021819)4.72428508
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.72073164
6cilium or flagellum-dependent cell motility (GO:0001539)4.59808631
7vocalization behavior (GO:0071625)4.34627111
8glutamate secretion (GO:0014047)4.17364528
9synaptic vesicle exocytosis (GO:0016079)4.15478078
10regulation of synaptic vesicle exocytosis (GO:2000300)4.05511713
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.05478179
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.01470749
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.99766831
14proline transport (GO:0015824)3.93721009
15exploration behavior (GO:0035640)3.88064515
16protein localization to synapse (GO:0035418)3.81332076
17regulation of glutamate receptor signaling pathway (GO:1900449)3.74764914
18dendrite morphogenesis (GO:0048813)3.60858498
19neuron cell-cell adhesion (GO:0007158)3.50227282
20clathrin coat assembly (GO:0048268)3.49599575
21regulation of synapse structural plasticity (GO:0051823)3.47050797
22regulation of synaptic vesicle transport (GO:1902803)3.46034439
23pyrimidine nucleobase catabolic process (GO:0006208)3.34462702
24acrosome assembly (GO:0001675)3.33545978
25neurotransmitter secretion (GO:0007269)3.25584799
26sperm motility (GO:0030317)3.23628036
27nucleobase catabolic process (GO:0046113)3.22906385
28axonemal dynein complex assembly (GO:0070286)3.21535593
29activation of protein kinase A activity (GO:0034199)3.21021613
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.20299030
31fusion of sperm to egg plasma membrane (GO:0007342)3.19421752
32calcium ion-dependent exocytosis (GO:0017156)3.16546909
33regulation of ARF protein signal transduction (GO:0032012)3.16531333
34dendritic spine morphogenesis (GO:0060997)3.16287027
35regulation of neuronal synaptic plasticity (GO:0048168)3.13929686
36embryonic retina morphogenesis in camera-type eye (GO:0060059)3.08733727
37negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.07150138
38negative regulation of cell killing (GO:0031342)3.07150138
39acrosome reaction (GO:0007340)3.03531092
40positive regulation of synapse maturation (GO:0090129)3.02377012
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.00999288
42ionotropic glutamate receptor signaling pathway (GO:0035235)2.98143859
43neuron recognition (GO:0008038)2.97521826
44cellular potassium ion homeostasis (GO:0030007)2.97146437
45axon extension (GO:0048675)2.94234874
46neurotransmitter-gated ion channel clustering (GO:0072578)2.91334744
47epithelial cilium movement (GO:0003351)2.85356067
48axonal fasciculation (GO:0007413)2.83073647
49innervation (GO:0060384)2.82802784
50sodium ion export (GO:0071436)2.82016219
51* vesicle transport along microtubule (GO:0047496)2.81854569
52synaptic vesicle endocytosis (GO:0048488)2.80601961
53postsynaptic membrane organization (GO:0001941)2.79693294
54nerve growth factor signaling pathway (GO:0038180)2.79313949
55cell migration in hindbrain (GO:0021535)2.76766351
56response to gravity (GO:0009629)2.76163580
57cerebellar granule cell differentiation (GO:0021707)2.72678555
58establishment of nucleus localization (GO:0040023)2.71664517
59regulation of clathrin-mediated endocytosis (GO:2000369)2.71418146
60* organelle transport along microtubule (GO:0072384)2.71295826
61protein targeting to Golgi (GO:0000042)2.70956038
62G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.70693720
63regulation of dendritic spine morphogenesis (GO:0061001)2.70524488
64apical protein localization (GO:0045176)2.70244411
65regulation of NFAT protein import into nucleus (GO:0051532)2.70080785
66neuromuscular process controlling balance (GO:0050885)2.69120353
67response to auditory stimulus (GO:0010996)2.68227154
68plasma membrane fusion (GO:0045026)2.67944686
69positive regulation of axon extension (GO:0045773)2.67658356
70neuron projection extension (GO:1990138)2.66822775
71gamma-aminobutyric acid transport (GO:0015812)2.66615012
72establishment of protein localization to Golgi (GO:0072600)2.64140005
73auditory behavior (GO:0031223)2.63250557
74presynaptic membrane assembly (GO:0097105)2.62650305
75central nervous system projection neuron axonogenesis (GO:0021952)2.62554281
76cilium movement (GO:0003341)2.62168495
77glutamate receptor signaling pathway (GO:0007215)2.61942316
78membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.61379713
79synaptic transmission, glutamatergic (GO:0035249)2.59964862
80regulation of neurotransmitter secretion (GO:0046928)2.58087152
81regulation of excitatory postsynaptic membrane potential (GO:0060079)2.57194851
82mating behavior (GO:0007617)2.56531332
83negative regulation of synaptic transmission, GABAergic (GO:0032229)2.54847492
84regulation of calcium ion-dependent exocytosis (GO:0017158)2.54586753
85piRNA metabolic process (GO:0034587)2.54228378
86regulation of synaptic plasticity (GO:0048167)2.51905794
87long-term memory (GO:0007616)2.51866056
88negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.50796991
89regulation of vesicle fusion (GO:0031338)2.50750816
90regulation of microtubule-based movement (GO:0060632)2.49478806
91cerebellar Purkinje cell layer development (GO:0021680)2.48397801
92presynaptic membrane organization (GO:0097090)2.48109972
93dopamine receptor signaling pathway (GO:0007212)2.47505772
94synapse assembly (GO:0007416)2.46929249
95neurotransmitter transport (GO:0006836)2.46382478
96desmosome organization (GO:0002934)2.46137077
97membrane depolarization during action potential (GO:0086010)2.46129399
98regulation of postsynaptic membrane potential (GO:0060078)2.45188204
99alanine transport (GO:0032328)2.44866336
100receptor recycling (GO:0001881)2.44564549
101cytoskeletal anchoring at plasma membrane (GO:0007016)2.44367802
102multicellular organism reproduction (GO:0032504)2.44338463
103neuron-neuron synaptic transmission (GO:0007270)2.43612515
104mitochondrion transport along microtubule (GO:0047497)2.43266867
105establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.43266867
106negative regulation of hormone biosynthetic process (GO:0032353)2.42988120
107long-term synaptic potentiation (GO:0060291)2.42507605
108protein localization to endosome (GO:0036010)2.40947811
109cellular response to nerve growth factor stimulus (GO:1990090)2.40617757
110response to nerve growth factor (GO:1990089)2.40617757
111regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.40433976
112intraspecies interaction between organisms (GO:0051703)2.40381757
113regulation of bile acid biosynthetic process (GO:0070857)2.39848390
114negative regulation of hormone metabolic process (GO:0032351)2.34922023
115detection of calcium ion (GO:0005513)2.33365161
116neuron remodeling (GO:0016322)2.31732208
117regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.31552011
118negative regulation of dendrite morphogenesis (GO:0050774)2.28846032
119adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.28123210
120epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.27514226
121asymmetric protein localization (GO:0008105)2.27383088
122auditory receptor cell differentiation (GO:0042491)2.27331925
123camera-type eye morphogenesis (GO:0048593)2.26536579
124cellular response to vitamin D (GO:0071305)2.24723146
125negative regulation of catenin import into nucleus (GO:0035414)2.24067059
126establishment or maintenance of monopolar cell polarity (GO:0061339)2.22907407
127establishment of monopolar cell polarity (GO:0061162)2.22907407
128negative regulation of keratinocyte proliferation (GO:0010839)2.22864917
129cellular sodium ion homeostasis (GO:0006883)2.22341892
130regulation of synapse maturation (GO:0090128)2.22159576
131membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.19510716
132regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.18816741
133macroautophagy (GO:0016236)2.17471698
134startle response (GO:0001964)2.17090143
135lymphangiogenesis (GO:0001946)2.16992169
136motile cilium assembly (GO:0044458)2.16715663
137regulation of axon extension involved in axon guidance (GO:0048841)2.16417779
138potassium ion homeostasis (GO:0055075)2.14931226
139chemosensory behavior (GO:0007635)2.14068888
140positive regulation of dendritic spine morphogenesis (GO:0061003)2.14013074
141membrane assembly (GO:0071709)2.13231722
142peripheral nervous system axon ensheathment (GO:0032292)2.11412707
143myelination in peripheral nervous system (GO:0022011)2.11412707
144neuronal ion channel clustering (GO:0045161)2.09969902
145dendritic spine organization (GO:0097061)2.09449669
146regulation of type B pancreatic cell apoptotic process (GO:2000674)2.06533314
147righting reflex (GO:0060013)2.04952472
148negative regulation of glycogen metabolic process (GO:0070874)2.04895534
149positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.02996950
150membrane hyperpolarization (GO:0060081)2.02515424
151cochlea development (GO:0090102)2.02067075

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.21937448
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.94958048
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.50427913
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.41179641
5GBX2_23144817_ChIP-Seq_PC3_Human2.29970978
6REST_21632747_ChIP-Seq_MESCs_Mouse2.21224039
7DROSHA_22980978_ChIP-Seq_HELA_Human2.20741674
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.17420306
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.05097521
10SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97703305
11RARB_27405468_Chip-Seq_BRAIN_Mouse1.96845278
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88533977
13MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85208190
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83037145
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82938598
16JARID2_20064375_ChIP-Seq_MESCs_Mouse1.80026451
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79494595
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75315090
19EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72333759
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72333759
21ZNF274_21170338_ChIP-Seq_K562_Hela1.64345098
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64214524
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.62523252
24REST_18959480_ChIP-ChIP_MESCs_Mouse1.61195398
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.60921953
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.60205580
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54726143
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.52773705
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51441105
30* SMAD4_21799915_ChIP-Seq_A2780_Human1.50857261
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46690531
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46456630
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46034164
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45019668
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43705849
36CTNNB1_20460455_ChIP-Seq_HCT116_Human1.43035949
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.40860628
38CDX2_20551321_ChIP-Seq_CACO-2_Human1.40319643
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40267793
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37862894
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.35436340
42AR_21572438_ChIP-Seq_LNCaP_Human1.35054084
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29250876
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28848361
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28069795
46TP53_18474530_ChIP-ChIP_U2OS_Human1.26993730
47AHR_22903824_ChIP-Seq_MCF-7_Human1.26151656
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.26054903
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26032592
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25989949
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25530353
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25067611
53KDM2B_26808549_Chip-Seq_K562_Human1.24255103
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.23496458
55ARNT_22903824_ChIP-Seq_MCF-7_Human1.22688543
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.21077948
57* FOXA2_19822575_ChIP-Seq_HepG2_Human1.19631065
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.19614655
59STAT3_23295773_ChIP-Seq_U87_Human1.19413656
60WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17727298
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17309312
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17304770
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16508917
64AR_25329375_ChIP-Seq_VCAP_Human1.15956742
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14920235
66ELK4_26923725_Chip-Seq_MESODERM_Mouse1.14402039
67AR_19668381_ChIP-Seq_PC3_Human1.12949162
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11587706
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11558246
70* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11016184
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10979628
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.10624878
73TCF4_23295773_ChIP-Seq_U87_Human1.10297946
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10223232
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09680345
76EED_16625203_ChIP-ChIP_MESCs_Mouse1.08813244
77SMAD3_21741376_ChIP-Seq_ESCs_Human1.08676486
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07695541
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06992958
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05819643
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05241160
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05212256
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05043316
84FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04990046
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03610464
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03000048
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03000048
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02926984
89FOXO3_23340844_ChIP-Seq_DLD1_Human1.00922316
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00675675
91FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00321782
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00192436
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.00080833
94ESR1_20079471_ChIP-ChIP_T-47D_Human0.99448127
95P300_19829295_ChIP-Seq_ESCs_Human0.99318661
96CBP_20019798_ChIP-Seq_JUKART_Human0.98535550
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98535550
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97395486
99* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97173259
100RING1B_27294783_Chip-Seq_ESCs_Mouse0.96765955
101TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96165279
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95916646
103SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95906539
104TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95593439
105ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95413443
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95273304
107SMAD4_21741376_ChIP-Seq_HESCs_Human0.94520392
108CJUN_26792858_Chip-Seq_BT549_Human0.93885731
109NANOG_18555785_Chip-Seq_ESCs_Mouse0.93873891
110DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93610488
111SMAD4_21741376_ChIP-Seq_EPCs_Human0.93555569
112OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93425808
113TET1_21490601_ChIP-Seq_MESCs_Mouse0.93262667
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92385949
115BCAT_22108803_ChIP-Seq_LS180_Human0.92252026
116KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91768019
117FUS_26573619_Chip-Seq_HEK293_Human0.91234398
118TP53_16413492_ChIP-PET_HCT116_Human0.91115320
119PIAS1_25552417_ChIP-Seq_VCAP_Human0.90720917
120SMAD3_21741376_ChIP-Seq_HESCs_Human0.90290573
121ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89918505
122FLI1_21867929_ChIP-Seq_TH2_Mouse0.89732465
123OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88733256
124RING1B_27294783_Chip-Seq_NPCs_Mouse0.87450190
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86248575
126KDM2B_26808549_Chip-Seq_REH_Human0.86086210
127NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85948999
128GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85846476
129TAF15_26573619_Chip-Seq_HEK293_Human0.85416636
130P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85125335
131TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83995587

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.23850177
2MP0000569_abnormal_digit_pigmentation4.11233393
3MP0004270_analgesia3.84226390
4MP0005410_abnormal_fertilization3.63304528
5MP0003635_abnormal_synaptic_transmissio3.62147532
6MP0009780_abnormal_chondrocyte_physiolo3.24708068
7MP0002063_abnormal_learning/memory/cond3.03726899
8MP0003880_abnormal_central_pattern2.76009614
9MP0005423_abnormal_somatic_nervous2.66198028
10MP0005409_darkened_coat_color2.55998914
11MP0002734_abnormal_mechanical_nocicepti2.46489715
12MP0009745_abnormal_behavioral_response2.45725763
13MP0009046_muscle_twitch2.45130371
14MP0003329_amyloid_beta_deposits2.45012744
15MP0003303_peritoneal_inflammation2.37101457
16MP0004858_abnormal_nervous_system2.36607476
17MP0001968_abnormal_touch/_nociception2.30264681
18MP0002064_seizures2.28632933
19MP0002572_abnormal_emotion/affect_behav2.23181230
20MP0000778_abnormal_nervous_system2.14421201
21MP0002909_abnormal_adrenal_gland2.08422766
22MP0001984_abnormal_olfaction2.02252446
23MP0004811_abnormal_neuron_physiology1.99704876
24MP0002876_abnormal_thyroid_physiology1.94850934
25MP0002733_abnormal_thermal_nociception1.91742159
26MP0002735_abnormal_chemical_nociception1.90725954
27MP0000604_amyloidosis1.85629325
28MP0003879_abnormal_hair_cell1.78368796
29MP0002184_abnormal_innervation1.77430815
30MP0005623_abnormal_meninges_morphology1.76312676
31MP0001440_abnormal_grooming_behavior1.73065780
32MP0003123_paternal_imprinting1.71382303
33MP0000534_abnormal_ureter_morphology1.67550144
34MP0001501_abnormal_sleep_pattern1.61156293
35MP0001486_abnormal_startle_reflex1.60882032
36MP0002736_abnormal_nociception_after1.59910438
37MP0001970_abnormal_pain_threshold1.59453493
38MP0002557_abnormal_social/conspecific_i1.52902144
39MP0004510_myositis1.52577220
40MP0010234_abnormal_vibrissa_follicle1.52209279
41MP0003698_abnormal_male_reproductive1.44553285
42MP0002272_abnormal_nervous_system1.44395150
43MP0008569_lethality_at_weaning1.44087701
44MP0002067_abnormal_sensory_capabilities1.42186418
45MP0005386_behavior/neurological_phenoty1.40617051
46MP0004924_abnormal_behavior1.40617051
47MP0003172_abnormal_lysosome_physiology1.38904378
48* MP0000955_abnormal_spinal_cord1.38527039
49MP0001348_abnormal_lacrimal_gland1.37659323
50MP0000537_abnormal_urethra_morphology1.36882520
51MP0003300_gastrointestinal_ulcer1.36228121
52MP0003633_abnormal_nervous_system1.34019375
53MP0009053_abnormal_anal_canal1.33523573
54MP0002882_abnormal_neuron_morphology1.32998468
55MP0003122_maternal_imprinting1.31674292
56MP0001944_abnormal_pancreas_morphology1.30673669
57MP0003942_abnormal_urinary_system1.30409401
58MP0005379_endocrine/exocrine_gland_phen1.30155555
59MP0002822_catalepsy1.29055576
60MP0003787_abnormal_imprinting1.27233124
61MP0008961_abnormal_basal_metabolism1.25479797
62MP0003868_abnormal_feces_composition1.24341249
63MP0001666_abnormal_nutrient_absorption1.23434675
64MP0002139_abnormal_hepatobiliary_system1.23091378
65MP0001485_abnormal_pinna_reflex1.22940104
66MP0008875_abnormal_xenobiotic_pharmacok1.22750465
67MP0004130_abnormal_muscle_cell1.22328659
68MP0005076_abnormal_cell_differentiation1.19426625
69MP0005187_abnormal_penis_morphology1.17687479
70MP0004134_abnormal_chest_morphology1.16041635
71MP0003195_calcinosis1.13089869
72MP0002066_abnormal_motor_capabilities/c1.10540084
73* MP0002152_abnormal_brain_morphology1.10361779
74MP0002090_abnormal_vision1.06237288
75MP0004885_abnormal_endolymph1.06153040
76MP0003634_abnormal_glial_cell1.05000474
77MP0000566_synostosis1.04984618
78MP0003631_nervous_system_phenotype1.04293161
79MP0004233_abnormal_muscle_weight1.03975248
80MP0003045_fibrosis1.03556279
81MP0000678_abnormal_parathyroid_gland1.01168204
82MP0005365_abnormal_bile_salt1.01044981
83MP0002089_abnormal_postnatal_growth/wei1.00549757
84MP0001756_abnormal_urination1.00526856
85MP0010678_abnormal_skin_adnexa1.00458753
86MP0005360_urolithiasis0.98905255
87MP0003690_abnormal_glial_cell0.97680497
88MP0001299_abnormal_eye_distance/0.96144388
89MP0003075_altered_response_to0.95660555
90MP0004043_abnormal_pH_regulation0.94901472
91MP0001765_abnormal_ion_homeostasis0.93800339
92MP0005551_abnormal_eye_electrophysiolog0.93558640
93MP0001502_abnormal_circadian_rhythm0.92531026
94MP0008877_abnormal_DNA_methylation0.92032637
95MP0000462_abnormal_digestive_system0.91241545
96MP0001188_hyperpigmentation0.89585542
97MP0005499_abnormal_olfactory_system0.88522331
98MP0005394_taste/olfaction_phenotype0.88522331
99MP0002163_abnormal_gland_morphology0.87913936
100MP0003937_abnormal_limbs/digits/tail_de0.87433214
101MP0005645_abnormal_hypothalamus_physiol0.87057957
102MP0002877_abnormal_melanocyte_morpholog0.86576394
103MP0002160_abnormal_reproductive_system0.85988640
104MP0002653_abnormal_ependyma_morphology0.83921910
105MP0004019_abnormal_vitamin_homeostasis0.83620296
106MP0001929_abnormal_gametogenesis0.83098537
107MP0004264_abnormal_extraembryonic_tissu0.81248367
108MP0002234_abnormal_pharynx_morphology0.81103243
109MP0003283_abnormal_digestive_organ0.80483816
110MP0003091_abnormal_cell_migration0.80477946
111MP0010368_abnormal_lymphatic_system0.79953157
112MP0002229_neurodegeneration0.79368764
113MP0008872_abnormal_physiological_respon0.79099293
114MP0000015_abnormal_ear_pigmentation0.77513676
115MP0003632_abnormal_nervous_system0.77119866
116MP0002161_abnormal_fertility/fecundity0.75382073
117MP0002928_abnormal_bile_duct0.75228737
118MP0003890_abnormal_embryonic-extraembry0.74360387
119MP0000383_abnormal_hair_follicle0.73180970
120MP0003936_abnormal_reproductive_system0.73080957
121MP0006276_abnormal_autonomic_nervous0.73020383
122MP0004185_abnormal_adipocyte_glucose0.70560299
123MP0005257_abnormal_intraocular_pressure0.70372258
124MP0010352_gastrointestinal_tract_polyps0.70229953
125MP0001664_abnormal_digestion0.70122886
126MP0005085_abnormal_gallbladder_physiolo0.69716625
127MP0004133_heterotaxia0.69321132
128MP0003705_abnormal_hypodermis_morpholog0.68762685
129MP0002069_abnormal_eating/drinking_beha0.68493349
130MP0005646_abnormal_pituitary_gland0.67849815
131MP0003183_abnormal_peptide_metabolism0.67157297
132* MP0003861_abnormal_nervous_system0.66658457
133MP0000013_abnormal_adipose_tissue0.66184633
134MP0005535_abnormal_body_temperature0.63633831
135MP0001177_atelectasis0.63544422
136MP0002896_abnormal_bone_mineralization0.63389501
137MP0005310_abnormal_salivary_gland0.59374560
138MP0008874_decreased_physiological_sensi0.59296371
139MP0010307_abnormal_tumor_latency0.58545954
140MP0000751_myopathy0.58131718
141MP0000631_abnormal_neuroendocrine_gland0.56966350
142MP0005166_decreased_susceptibility_to0.56452503
143MP0010386_abnormal_urinary_bladder0.55029952
144MP0005248_abnormal_Harderian_gland0.52135916
145MP0002752_abnormal_somatic_nervous0.49659612

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.18047745
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.00552722
3Dynein arm defect of respiratory motile cilia (HP:0012255)3.87739512
4Absent/shortened dynein arms (HP:0200106)3.87739512
5Visual hallucinations (HP:0002367)3.69261740
6Amyotrophic lateral sclerosis (HP:0007354)3.60583913
7Supranuclear gaze palsy (HP:0000605)3.57312958
8Focal motor seizures (HP:0011153)3.53525521
9Abnormality of the lower motor neuron (HP:0002366)3.52610964
10Focal seizures (HP:0007359)3.49361181
11Papilledema (HP:0001085)3.49206167
12Action tremor (HP:0002345)3.38884646
13Mutism (HP:0002300)3.31743921
14Progressive cerebellar ataxia (HP:0002073)3.31504929
15Cerebral inclusion bodies (HP:0100314)3.19628425
16Epileptic encephalopathy (HP:0200134)3.09072533
17Inappropriate behavior (HP:0000719)2.85150920
18Neurofibrillary tangles (HP:0002185)2.84844765
19Abnormal respiratory motile cilium physiology (HP:0012261)2.81850366
20Urinary bladder sphincter dysfunction (HP:0002839)2.73751921
21Hyperventilation (HP:0002883)2.71143112
22Abnormality of binocular vision (HP:0011514)2.69830399
23Diplopia (HP:0000651)2.69830399
24Rhinitis (HP:0012384)2.60411093
25Insidious onset (HP:0003587)2.58726169
26Termporal pattern (HP:0011008)2.58726169
27Disinhibition (HP:0000734)2.55394238
28Apathy (HP:0000741)2.54633631
29Abnormal pancreas size (HP:0012094)2.53270589
30Drooling (HP:0002307)2.46049840
31Excessive salivation (HP:0003781)2.46049840
32Papillary thyroid carcinoma (HP:0002895)2.44771267
33Ankle clonus (HP:0011448)2.44420335
34Infertility (HP:0000789)2.40801960
35Absent frontal sinuses (HP:0002688)2.39633029
36Impaired vibration sensation in the lower limbs (HP:0002166)2.38670279
37Depression (HP:0000716)2.36184125
38Urinary urgency (HP:0000012)2.35354393
39Abnormality of the corticospinal tract (HP:0002492)2.34031575
40Atonic seizures (HP:0010819)2.33472404
41Truncal ataxia (HP:0002078)2.32805263
42Obstructive sleep apnea (HP:0002870)2.31501338
43Genetic anticipation (HP:0003743)2.30604306
44Diminished motivation (HP:0000745)2.30068164
45Abnormality of the nasal septum (HP:0000419)2.27467056
46Abnormal respiratory epithelium morphology (HP:0012253)2.26573062
47Abnormal respiratory motile cilium morphology (HP:0005938)2.26573062
48Impaired smooth pursuit (HP:0007772)2.22082212
49Poor eye contact (HP:0000817)2.21889060
50Absence seizures (HP:0002121)2.21490643
51Abnormality of ocular smooth pursuit (HP:0000617)2.19977421
52Abnormal social behavior (HP:0012433)2.16819427
53Impaired social interactions (HP:0000735)2.16819427
54Nasal polyposis (HP:0100582)2.16027658
55Dysdiadochokinesis (HP:0002075)2.14965806
56Postural instability (HP:0002172)2.14084150
57Abnormal ciliary motility (HP:0012262)2.12317835
58Generalized tonic-clonic seizures (HP:0002069)2.11275287
59Neuronal loss in central nervous system (HP:0002529)2.10915787
60Dysmetric saccades (HP:0000641)2.10736365
61Heterotopia (HP:0002282)2.09500008
62Gaze-evoked nystagmus (HP:0000640)2.09495267
63Macroorchidism (HP:0000053)2.08333655
64Hyperphosphatemia (HP:0002905)2.07294907
65Megalencephaly (HP:0001355)2.06402377
66Agitation (HP:0000713)2.06080734
67Menstrual irregularities (HP:0000858)2.05217320
68Gait imbalance (HP:0002141)2.03010104
69Febrile seizures (HP:0002373)2.01960381
70Hemiparesis (HP:0001269)2.01515117
71Broad-based gait (HP:0002136)1.97547917
72Short 1st metacarpal (HP:0010034)1.96914741
73Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.96914741
74Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.95721061
75Intellectual disability, profound (HP:0002187)1.94751181
76Amblyopia (HP:0000646)1.93774990
77Chronic bronchitis (HP:0004469)1.93282749
78Pachygyria (HP:0001302)1.92840959
79Akinesia (HP:0002304)1.92830512
80Abnormal eating behavior (HP:0100738)1.88714316
81Lower limb amyotrophy (HP:0007210)1.87602235
82Insomnia (HP:0100785)1.87599591
83Hyperacusis (HP:0010780)1.87382036
84Lower limb muscle weakness (HP:0007340)1.86993785
85Subacute progressive viral hepatitis (HP:0006572)1.84495545
86Thyroid carcinoma (HP:0002890)1.84030026
87Spastic gait (HP:0002064)1.84020143
88Hyperactive renin-angiotensin system (HP:0000841)1.83190157
89Hypercortisolism (HP:0001578)1.82977250
90Limb dystonia (HP:0002451)1.81391517
91Dialeptic seizures (HP:0011146)1.81345809
92Anxiety (HP:0000739)1.81083100
93Aqueductal stenosis (HP:0002410)1.80498321
94Hypoplasia of the brainstem (HP:0002365)1.80026508
95Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80026508
96Enlarged penis (HP:0000040)1.79122279
97Dysmetria (HP:0001310)1.77977299
98Impaired vibratory sensation (HP:0002495)1.77756937
99Hypercalciuria (HP:0002150)1.77731224
100Late onset (HP:0003584)1.77388991
101Arterial tortuosity (HP:0005116)1.77372494
102Hand muscle atrophy (HP:0009130)1.77137553
103Abnormality of the 1st metacarpal (HP:0010009)1.76733488
104Stereotypic behavior (HP:0000733)1.76279588
105Tubular atrophy (HP:0000092)1.75934930
106Overgrowth (HP:0001548)1.75766813
107Vascular calcification (HP:0004934)1.75654837
108Renovascular hypertension (HP:0100817)1.74713274
109Cardiovascular calcification (HP:0011915)1.74179940
110Torticollis (HP:0000473)1.74106891
111Intention tremor (HP:0002080)1.73934330
112Pointed chin (HP:0000307)1.72666499
113Bronchiectasis (HP:0002110)1.71993475
114Bronchomalacia (HP:0002780)1.71604879
115EEG with generalized epileptiform discharges (HP:0011198)1.70791966
116Hyperparathyroidism (HP:0000843)1.70533389
117Progressive inability to walk (HP:0002505)1.70444759
118Ankyloglossia (HP:0010296)1.70306911
119Epileptiform EEG discharges (HP:0011182)1.69981108
120Buphthalmos (HP:0000557)1.69608872
121Abnormality of the nasal mucosa (HP:0000433)1.69323174
122Unilateral renal agenesis (HP:0000122)1.69209910
123Absent speech (HP:0001344)1.68783922
124Abnormality of the distal phalanges of the toes (HP:0010182)1.67434003
125Vascular tortuosity (HP:0004948)1.66049377
126Shawl scrotum (HP:0000049)1.64681543
127Mitral stenosis (HP:0001718)1.63997119
128Abnormality of glutamine family amino acid metabolism (HP:0010902)1.63575305
129Vertebral arch anomaly (HP:0008438)1.62914478
130Congenital sensorineural hearing impairment (HP:0008527)1.62626113
131Insulin-resistant diabetes mellitus (HP:0000831)1.62489673
132Short nail (HP:0001799)1.62470739
133Oligodontia (HP:0000677)1.62428736
134Short phalanx of the thumb (HP:0009660)1.62288517
135Spinal cord compression (HP:0002176)1.60480149
136Nephronophthisis (HP:0000090)1.58820766
137Osteomalacia (HP:0002749)1.57304752
138Cystic liver disease (HP:0006706)1.56007637
139Abnormality of renin-angiotensin system (HP:0000847)1.55677284
140Hypoventilation (HP:0002791)1.55017874
141Pancreatic fibrosis (HP:0100732)1.52846515
142Sleep apnea (HP:0010535)1.52744494
143Chorioretinal atrophy (HP:0000533)1.50568718
144Coronal craniosynostosis (HP:0004440)1.50263987
145Hypsarrhythmia (HP:0002521)1.50030093
146Fetal akinesia sequence (HP:0001989)1.47936859
147Elfin facies (HP:0004428)1.46492044
148Short femoral neck (HP:0100864)1.46396953
149Increased circulating renin level (HP:0000848)1.46374394
150Flat acetabular roof (HP:0003180)1.45288395
151Pheochromocytoma (HP:0002666)1.45240826
152True hermaphroditism (HP:0010459)1.44526633
153Morphological abnormality of the middle ear (HP:0008609)1.43661407
154Hyperaldosteronism (HP:0000859)1.43372569
155Abnormality of proline metabolism (HP:0010907)1.43359117
156Hydroxyprolinuria (HP:0003080)1.43359117
157Cutaneous finger syndactyly (HP:0010554)1.41972793
158Abnormality of the renal medulla (HP:0100957)1.41959670
159Urethral obstruction (HP:0000796)1.41021027
160Abnormality of the gastric mucosa (HP:0004295)1.40163308
161Hamartoma of the eye (HP:0010568)1.40100224

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.00801597
2MAP3K93.97401432
3EPHA22.94425189
4NTRK32.85060860
5PRKD32.71313989
6MAP3K42.44751229
7PDK42.35544817
8PDK32.35544817
9MINK12.24511455
10PAK62.18779734
11DAPK22.17561012
12MST1R2.07809401
13EPHA42.02837263
14MAP2K71.92736766
15KSR21.92418595
16CAMKK11.90668542
17NTRK21.83410867
18RIPK41.81765849
19MAP3K21.81149206
20TRIB31.78803538
21TAOK11.66586532
22NTRK11.65546334
23SIK21.62667634
24MET1.55153101
25TYRO31.53902790
26TESK11.44096340
27LATS21.43453205
28CAMK1G1.42421769
29PTK2B1.40204482
30PNCK1.39306510
31RET1.37712615
32KSR11.33674062
33STK381.32644674
34TNIK1.27886933
35SCYL21.27702466
36STK391.25976422
37CDK51.25910454
38PHKG11.23249901
39PHKG21.23249901
40MAP2K41.22761501
41PLK21.21532483
42PDK21.19356971
43STK38L1.17374289
44TSSK61.13132236
45MAPK131.06622307
46RIPK11.02984576
47ICK1.02879610
48ALK1.01453748
49GRK11.00200164
50SIK10.98070767
51ERBB30.97129875
52PRKCH0.92828787
53DAPK10.92212740
54PAK30.91003926
55EPHB20.90490318
56LATS10.90095502
57MARK20.89235964
58PRKCI0.88850720
59MAPK150.85048421
60BCR0.84168092
61AKT30.83082571
62WNK40.82767233
63CAMKK20.82683401
64PDK10.82228210
65CSNK1G20.81312760
66STK110.80421167
67ADRBK20.80027262
68PRKCG0.77302621
69GRK50.76318106
70PRKCE0.76035770
71FES0.75684090
72PDGFRB0.75382529
73PKN20.74426950
74PDGFRA0.73911135
75PINK10.70948249
76FGFR30.68713962
77LIMK10.68584130
78WNK30.68093112
79NEK60.67554724
80FGFR20.67517007
81CAMK2B0.63717968
82MAP3K10.62856606
83SGK30.62245341
84ERBB40.61885592
85PDPK10.60300487
86MAPKAPK30.60286682
87FGR0.60057465
88WNK10.59868914
89PRKCZ0.58595565
90STK30.57434864
91RPS6KA20.57418181
92TRPM70.56893402
93STK240.56830024
94CDK140.56672257
95FYN0.56594643
96EEF2K0.56084774
97CDK150.56016456
98EPHA30.55574048
99CAMK1D0.55287760
100CDK180.55042577
101CSNK1E0.54879731
102PRKD20.54142214
103BRSK10.53907967
104PRKG20.53734606
105MAP3K120.53508071
106LMTK20.53285127
107MST40.51714888
108JAK10.50908625
109FRK0.50358201
110SGK10.50339133
111MTOR0.49373948
112CDC42BPA0.48199152
113DYRK20.47736932
114ROCK20.47595049
115DDR20.46611399
116PRKAA10.45098429
117RPS6KB10.44920413
118PTK20.44566144
119CDK11A0.43738386
120CAMK2A0.43488223
121CASK0.42451245
122MAP3K50.42278210
123FGFR40.41882069
124MAP3K130.40908689
125SGK20.39641081
126UHMK10.38796778
127SGK4940.35082493
128SGK2230.35082493
129BMX0.34698210
130EGFR0.34546206
131RPS6KA30.33575653
132PTK60.32662571
133MAP3K70.32521373
134CSNK1D0.32510464
135SRC0.32225725
136MAPK120.32212683
137FER0.31643632
138CCNB10.31384868

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.39232827
2Olfactory transduction_Homo sapiens_hsa047402.17541983
3Long-term potentiation_Homo sapiens_hsa047202.11096787
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.10075722
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96699773
6Circadian entrainment_Homo sapiens_hsa047131.93469543
7Nicotine addiction_Homo sapiens_hsa050331.86062249
8Dopaminergic synapse_Homo sapiens_hsa047281.74680617
9Glutamatergic synapse_Homo sapiens_hsa047241.74518974
10Amphetamine addiction_Homo sapiens_hsa050311.73613210
11GABAergic synapse_Homo sapiens_hsa047271.65032468
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.63148399
13Morphine addiction_Homo sapiens_hsa050321.63022601
14Cholinergic synapse_Homo sapiens_hsa047251.60718425
15Dorso-ventral axis formation_Homo sapiens_hsa043201.60133978
16Vitamin B6 metabolism_Homo sapiens_hsa007501.57633521
17Renin secretion_Homo sapiens_hsa049241.57468910
18Salivary secretion_Homo sapiens_hsa049701.53520705
19Type II diabetes mellitus_Homo sapiens_hsa049301.52631421
20Bile secretion_Homo sapiens_hsa049761.51008382
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49618615
22Insulin secretion_Homo sapiens_hsa049111.48193785
23Gastric acid secretion_Homo sapiens_hsa049711.45420499
24Glioma_Homo sapiens_hsa052141.45242486
25Histidine metabolism_Homo sapiens_hsa003401.41537804
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41379087
27Estrogen signaling pathway_Homo sapiens_hsa049151.41138731
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39172839
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.38121190
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35337387
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33872089
32Oxytocin signaling pathway_Homo sapiens_hsa049211.33611474
33GnRH signaling pathway_Homo sapiens_hsa049121.29953719
34Caffeine metabolism_Homo sapiens_hsa002321.28060623
35Axon guidance_Homo sapiens_hsa043601.26459728
36Fatty acid biosynthesis_Homo sapiens_hsa000611.26422454
37Cocaine addiction_Homo sapiens_hsa050301.21565001
38Long-term depression_Homo sapiens_hsa047301.19237845
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19153452
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.17293089
41mTOR signaling pathway_Homo sapiens_hsa041501.13512363
42Gap junction_Homo sapiens_hsa045401.13002371
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12691370
44Phototransduction_Homo sapiens_hsa047441.12482365
45Hippo signaling pathway_Homo sapiens_hsa043901.12076020
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11485088
47ErbB signaling pathway_Homo sapiens_hsa040121.11364298
48Chemical carcinogenesis_Homo sapiens_hsa052041.10414820
49Tight junction_Homo sapiens_hsa045301.09652593
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09021748
51Endometrial cancer_Homo sapiens_hsa052131.08323993
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08003426
53VEGF signaling pathway_Homo sapiens_hsa043701.07264540
54Neurotrophin signaling pathway_Homo sapiens_hsa047221.05078893
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03764228
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03247919
57Cyanoamino acid metabolism_Homo sapiens_hsa004601.01745902
58cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00905343
59Serotonergic synapse_Homo sapiens_hsa047261.00627197
60Taste transduction_Homo sapiens_hsa047420.99767258
61cAMP signaling pathway_Homo sapiens_hsa040240.99544857
62Protein digestion and absorption_Homo sapiens_hsa049740.95512187
63Fat digestion and absorption_Homo sapiens_hsa049750.92611883
64Butanoate metabolism_Homo sapiens_hsa006500.91579692
65Phenylalanine metabolism_Homo sapiens_hsa003600.91512843
66Calcium signaling pathway_Homo sapiens_hsa040200.90127178
67Retinol metabolism_Homo sapiens_hsa008300.89096052
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87570384
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.87142139
70Renal cell carcinoma_Homo sapiens_hsa052110.86676016
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86290937
72Collecting duct acid secretion_Homo sapiens_hsa049660.84553086
73Prolactin signaling pathway_Homo sapiens_hsa049170.84184053
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83447862
75Glucagon signaling pathway_Homo sapiens_hsa049220.82992741
76Hedgehog signaling pathway_Homo sapiens_hsa043400.82817295
77Mineral absorption_Homo sapiens_hsa049780.81670840
78Melanogenesis_Homo sapiens_hsa049160.80451992
79MAPK signaling pathway_Homo sapiens_hsa040100.79961810
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79809417
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79601373
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79320285
83Colorectal cancer_Homo sapiens_hsa052100.78784113
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78529897
85Oocyte meiosis_Homo sapiens_hsa041140.78069976
86Endocytosis_Homo sapiens_hsa041440.77979140
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77817116
88Renin-angiotensin system_Homo sapiens_hsa046140.77560890
89Sphingolipid metabolism_Homo sapiens_hsa006000.76740600
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76546191
91Non-small cell lung cancer_Homo sapiens_hsa052230.75399462
92Sulfur metabolism_Homo sapiens_hsa009200.74802903
93Choline metabolism in cancer_Homo sapiens_hsa052310.74525870
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74411098
95Basal cell carcinoma_Homo sapiens_hsa052170.73207519
96Chemokine signaling pathway_Homo sapiens_hsa040620.72930028
97Osteoclast differentiation_Homo sapiens_hsa043800.72679994
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.72648131
99beta-Alanine metabolism_Homo sapiens_hsa004100.72559956
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72136748
101Arginine biosynthesis_Homo sapiens_hsa002200.72046783
102Thyroid hormone synthesis_Homo sapiens_hsa049180.71977771
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71705452
104Starch and sucrose metabolism_Homo sapiens_hsa005000.70768969
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69593314
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.69438545
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69437745
108T cell receptor signaling pathway_Homo sapiens_hsa046600.69050574
109PPAR signaling pathway_Homo sapiens_hsa033200.68357457
110Insulin signaling pathway_Homo sapiens_hsa049100.68016572
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67341216
112ECM-receptor interaction_Homo sapiens_hsa045120.66821536
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.66405964
114Pancreatic cancer_Homo sapiens_hsa052120.65231350
115Chronic myeloid leukemia_Homo sapiens_hsa052200.65095262
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.64271246
117B cell receptor signaling pathway_Homo sapiens_hsa046620.63608214
118Rap1 signaling pathway_Homo sapiens_hsa040150.63411862
119Ras signaling pathway_Homo sapiens_hsa040140.61401968
120Adherens junction_Homo sapiens_hsa045200.60964752
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60526236
122Selenocompound metabolism_Homo sapiens_hsa004500.60027122
123Tyrosine metabolism_Homo sapiens_hsa003500.59472997
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59396659
125Prion diseases_Homo sapiens_hsa050200.58273714
126Vibrio cholerae infection_Homo sapiens_hsa051100.57322607
127Tuberculosis_Homo sapiens_hsa051520.56979562
128Viral myocarditis_Homo sapiens_hsa054160.56959162
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56905896
130Glycerolipid metabolism_Homo sapiens_hsa005610.56843723
131Inositol phosphate metabolism_Homo sapiens_hsa005620.56763671
132Pancreatic secretion_Homo sapiens_hsa049720.55007557
133Type I diabetes mellitus_Homo sapiens_hsa049400.54735207
134Wnt signaling pathway_Homo sapiens_hsa043100.54596913
135Circadian rhythm_Homo sapiens_hsa047100.54249626
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53929160
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53381266
138Salmonella infection_Homo sapiens_hsa051320.53359961
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52959115
140Amoebiasis_Homo sapiens_hsa051460.52856777
141Focal adhesion_Homo sapiens_hsa045100.52819703
142Toxoplasmosis_Homo sapiens_hsa051450.51606202
143Tryptophan metabolism_Homo sapiens_hsa003800.51166081
144Dilated cardiomyopathy_Homo sapiens_hsa054140.51124738
145Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50995468
146AMPK signaling pathway_Homo sapiens_hsa041520.50713537
147Platelet activation_Homo sapiens_hsa046110.50549064
148Insulin resistance_Homo sapiens_hsa049310.49879459
149Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49283587

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