KIF4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)6.85329286
2mitotic sister chromatid segregation (GO:0000070)6.76659972
3sister chromatid segregation (GO:0000819)6.58257874
4protein localization to kinetochore (GO:0034501)6.37810535
5mitotic metaphase plate congression (GO:0007080)6.27101777
6regulation of attachment of spindle microtubules to kinetochore (GO:0051988)6.18219710
7protein localization to chromosome, centromeric region (GO:0071459)6.10616156
8DNA unwinding involved in DNA replication (GO:0006268)5.62670364
9metaphase plate congression (GO:0051310)5.60217912
10nuclear pore complex assembly (GO:0051292)5.43800004
11kinetochore organization (GO:0051383)5.29320351
12regulation of spindle organization (GO:0090224)5.26158955
13regulation of mitotic spindle organization (GO:0060236)5.19721745
14establishment of chromosome localization (GO:0051303)4.99862510
15nuclear pore organization (GO:0006999)4.90479133
16CENP-A containing nucleosome assembly (GO:0034080)4.86236491
17DNA strand elongation involved in DNA replication (GO:0006271)4.85903215
18chromatin remodeling at centromere (GO:0031055)4.74449413
19DNA strand elongation (GO:0022616)4.71761808
20DNA topological change (GO:0006265)4.67953143
21chromosome condensation (GO:0030261)4.65097453
22mitotic sister chromatid cohesion (GO:0007064)4.62437266
23regulation of chromosome segregation (GO:0051983)4.47448872
24spindle checkpoint (GO:0031577)4.44565110
25positive regulation of chromosome segregation (GO:0051984)4.43109002
26telomere maintenance via semi-conservative replication (GO:0032201)4.42957919
27DNA ligation (GO:0006266)4.42001798
28kinetochore assembly (GO:0051382)4.36505717
29mitotic nuclear envelope disassembly (GO:0007077)4.31866593
30chromosome segregation (GO:0007059)4.23279385
31protein localization to chromosome (GO:0034502)4.16083252
32DNA replication checkpoint (GO:0000076)4.15697898
33negative regulation of chromosome segregation (GO:0051985)4.14810924
34establishment of integrated proviral latency (GO:0075713)4.13107727
35mitotic spindle checkpoint (GO:0071174)4.08935849
36negative regulation of mitotic metaphase/anaphase transition (GO:0045841)4.02831826
37negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.02831826
38negative regulation of mitotic sister chromatid segregation (GO:0033048)4.02831826
39negative regulation of mitotic sister chromatid separation (GO:2000816)4.02831826
40negative regulation of sister chromatid segregation (GO:0033046)4.02831826
41DNA replication-independent nucleosome assembly (GO:0006336)4.02389703
42DNA replication-independent nucleosome organization (GO:0034724)4.02389703
43membrane disassembly (GO:0030397)4.02242559
44nuclear envelope disassembly (GO:0051081)4.02242559
45DNA packaging (GO:0006323)4.01536010
46pore complex assembly (GO:0046931)4.01363299
47histone exchange (GO:0043486)3.98408519
48regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.96036188
49regulation of mitotic metaphase/anaphase transition (GO:0030071)3.96036188
50mitotic spindle assembly checkpoint (GO:0007094)3.94742374
51mitotic recombination (GO:0006312)3.94414486
52regulation of sister chromatid segregation (GO:0033045)3.91947317
53regulation of mitotic sister chromatid separation (GO:0010965)3.91947317
54regulation of mitotic sister chromatid segregation (GO:0033047)3.91947317
55attachment of spindle microtubules to kinetochore (GO:0008608)3.91635657
56positive regulation of mitotic sister chromatid separation (GO:1901970)3.90967804
57positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.90967804
58positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.90967804
59spindle assembly checkpoint (GO:0071173)3.90199220
60DNA replication initiation (GO:0006270)3.79963936
61telomere maintenance via recombination (GO:0000722)3.78797114
62regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.69790015
63microtubule depolymerization (GO:0007019)3.67942412
64meiotic chromosome segregation (GO:0045132)3.67235981
65regulation of sister chromatid cohesion (GO:0007063)3.60031588
66regulation of centrosome cycle (GO:0046605)3.59659538
67regulation of centriole replication (GO:0046599)3.51127817
68chromatin assembly or disassembly (GO:0006333)3.46404813
69ATP-dependent chromatin remodeling (GO:0043044)3.37027647
70nucleotide-excision repair, DNA gap filling (GO:0006297)3.34697358
71anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.30371742
72DNA conformation change (GO:0071103)3.29899500
73negative regulation of mitosis (GO:0045839)3.28917474
74mitotic cell cycle (GO:0000278)3.25350644
75ventricular cardiac muscle cell development (GO:0055015)3.25063461
76spindle assembly involved in mitosis (GO:0090307)3.25038076
77regulation of DNA endoreduplication (GO:0032875)3.24628834
78non-recombinational repair (GO:0000726)3.21386190
79double-strand break repair via nonhomologous end joining (GO:0006303)3.21386190
80mitotic cytokinesis (GO:0000281)3.20635805
81heterochromatin organization (GO:0070828)3.19494720
82mitotic G2/M transition checkpoint (GO:0044818)3.15933105
83mitotic spindle organization (GO:0007052)3.15048467
84nuclear envelope organization (GO:0006998)3.13724282
85histone-serine phosphorylation (GO:0035404)3.11616853
86DNA replication-dependent nucleosome organization (GO:0034723)3.09921620
87DNA replication-dependent nucleosome assembly (GO:0006335)3.09921620
88DNA duplex unwinding (GO:0032508)3.08599874
89establishment of viral latency (GO:0019043)3.08523107
90protein complex localization (GO:0031503)3.03517516
91chromosome organization (GO:0051276)3.03490734
92telomere maintenance via telomere lengthening (GO:0010833)3.03137760
93DNA geometric change (GO:0032392)2.99790702
94protein K6-linked ubiquitination (GO:0085020)2.98781604
95mitotic nuclear division (GO:0007067)2.96347932
96spindle organization (GO:0007051)2.94993963
97regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92264501
98negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.90316827
99establishment of mitotic spindle localization (GO:0040001)2.90312020
100regulation of spindle checkpoint (GO:0090231)2.89922213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human8.56311498
2* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human5.19940636
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human5.12156769
4AR_21909140_ChIP-Seq_LNCAP_Human3.80347301
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.71562422
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.43232021
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.40595669
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.88125401
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.82032795
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.61701741
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.60702122
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.59132114
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56424046
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.54685148
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.34155871
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28251566
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.21800370
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20143475
19* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.18030424
20MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.02544048
21MYCN_18555785_ChIP-Seq_MESCs_Mouse2.01329198
22E2F7_22180533_ChIP-Seq_HELA_Human10.0723954
23XRN2_22483619_ChIP-Seq_HELA_Human1.97706281
24THAP11_20581084_ChIP-Seq_MESCs_Mouse1.96891120
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90942290
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.87937967
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.84450266
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.83439983
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83101477
30DCP1A_22483619_ChIP-Seq_HELA_Human1.82168127
31TTF2_22483619_ChIP-Seq_HELA_Human1.75387023
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74596542
33ELK1_19687146_ChIP-ChIP_HELA_Human1.71662030
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70122500
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66332850
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65471632
37ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62638684
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.53013247
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.51511302
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49753391
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48962440
42* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.47306354
43FOXP3_21729870_ChIP-Seq_TREG_Human1.46006101
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45979029
45GABP_19822575_ChIP-Seq_HepG2_Human1.38492375
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38488662
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37108050
48E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.36621657
49CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.32844490
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32671719
51KDM5A_27292631_Chip-Seq_BREAST_Human1.32131544
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27435147
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.25236347
54VDR_23849224_ChIP-Seq_CD4+_Human1.20297842
55CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19462089
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16319277
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14345425
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14040818
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10798282
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10509218
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08953962
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08168788
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04231314
64SOX17_20123909_ChIP-Seq_XEN_Mouse1.03804872
65CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00248437
66MYC_18940864_ChIP-ChIP_HL60_Human0.97861460
67ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95550008
68CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94474738
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94455992
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93434227
71NANOG_21062744_ChIP-ChIP_HESCs_Human0.92997339
72NANOG_16153702_ChIP-ChIP_HESCs_Human0.92453904
73YY1_21170310_ChIP-Seq_MESCs_Mouse0.92161679
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89597829
75SOX2_16153702_ChIP-ChIP_HESCs_Human0.89217717
76SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87319752
77CHD1_26751641_Chip-Seq_LNCaP_Human0.82063953
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81533351
79SRF_21415370_ChIP-Seq_HL-1_Mouse0.80169547
80ELF1_17652178_ChIP-ChIP_JURKAT_Human0.78985545
81CIITA_25753668_ChIP-Seq_RAJI_Human0.77603673
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.76764340
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.76272287
84STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75686634
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.75387725
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.75303734
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.73072339
88TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.73023223
89MYC_22102868_ChIP-Seq_BL_Human0.72957198
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.70976501
91RBPJ_22232070_ChIP-Seq_NCS_Mouse0.70355558
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.69268215
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.68345650
94TFEB_21752829_ChIP-Seq_HELA_Human0.66671022
95POU5F1_16153702_ChIP-ChIP_HESCs_Human0.66307253
96FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.66015065
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.64767688
98ZNF263_19887448_ChIP-Seq_K562_Human0.63596637
99PKCTHETA_26484144_Chip-Seq_BREAST_Human0.63393941
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.62827843

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.18426123
2MP0003693_abnormal_embryo_hatching5.07799605
3MP0003111_abnormal_nucleus_morphology4.84098532
4MP0003077_abnormal_cell_cycle4.12668727
5MP0004957_abnormal_blastocyst_morpholog3.97336292
6MP0008057_abnormal_DNA_replication3.64405160
7MP0008058_abnormal_DNA_repair3.29946254
8MP0008932_abnormal_embryonic_tissue3.22064711
9MP0003718_maternal_effect2.68049731
10MP0010030_abnormal_orbit_morphology2.47611691
11MP0008007_abnormal_cellular_replicative2.40217300
12MP0006292_abnormal_olfactory_placode2.19537894
13MP0001730_embryonic_growth_arrest2.17776931
14MP0009697_abnormal_copulation2.08540513
15MP0000350_abnormal_cell_proliferation2.04245373
16MP0010307_abnormal_tumor_latency1.94099299
17MP0005380_embryogenesis_phenotype1.81920512
18MP0001672_abnormal_embryogenesis/_devel1.81920512
19MP0001697_abnormal_embryo_size1.77684291
20MP0003890_abnormal_embryonic-extraembry1.76734403
21MP0010352_gastrointestinal_tract_polyps1.75592805
22MP0001293_anophthalmia1.71245659
23MP0002085_abnormal_embryonic_tissue1.66065573
24MP0000537_abnormal_urethra_morphology1.63765819
25MP0002084_abnormal_developmental_patter1.58327068
26MP0002080_prenatal_lethality1.57470836
27MP0003937_abnormal_limbs/digits/tail_de1.54246988
28MP0003984_embryonic_growth_retardation1.52973574
29MP0003705_abnormal_hypodermis_morpholog1.47197411
30MP0002088_abnormal_embryonic_growth/wei1.46282711
31MP0002697_abnormal_eye_size1.42471011
32MP0009672_abnormal_birth_weight1.41688596
33MP0003941_abnormal_skin_development1.38603157
34MP0002877_abnormal_melanocyte_morpholog1.35866328
35MP0000566_synostosis1.34284516
36MP0005076_abnormal_cell_differentiation1.31404963
37MP0003786_premature_aging1.27895693
38MP0000313_abnormal_cell_death1.26306024
39MP0001286_abnormal_eye_development1.22499845
40MP0002210_abnormal_sex_determination1.19003677
41MP0001346_abnormal_lacrimal_gland1.18721984
42MP0000428_abnormal_craniofacial_morphol1.16972247
43MP0002086_abnormal_extraembryonic_tissu1.15916104
44MP0004197_abnormal_fetal_growth/weight/1.15837049
45MP0003950_abnormal_plasma_membrane1.14275558
46MP0002234_abnormal_pharynx_morphology1.13877174
47MP0002938_white_spotting1.13161512
48MP0010234_abnormal_vibrissa_follicle1.10444098
49MP0002092_abnormal_eye_morphology1.10184671
50MP0002233_abnormal_nose_morphology1.10091563
51MP0001929_abnormal_gametogenesis1.09871502
52MP0002111_abnormal_tail_morphology1.07342600
53MP0004233_abnormal_muscle_weight1.07271102
54MP0003315_abnormal_perineum_morphology1.06711454
55MP0008789_abnormal_olfactory_epithelium1.04202246
56MP0003755_abnormal_palate_morphology0.98300758
57MP0008877_abnormal_DNA_methylation0.97419376
58MP0009053_abnormal_anal_canal0.93687288
59MP0003861_abnormal_nervous_system0.92599636
60MP0001145_abnormal_male_reproductive0.91832341
61MP0003385_abnormal_body_wall0.91525180
62MP0000762_abnormal_tongue_morphology0.90905941
63MP0005395_other_phenotype0.90615610
64MP0000358_abnormal_cell_content/0.90311046
65MP0003935_abnormal_craniofacial_develop0.88316470
66MP0002396_abnormal_hematopoietic_system0.88236266
67MP0009703_decreased_birth_body0.87828385
68MP0002019_abnormal_tumor_incidence0.87250494
69MP0005623_abnormal_meninges_morphology0.86897622
70MP0003119_abnormal_digestive_system0.86711338
71MP0000653_abnormal_sex_gland0.86069520
72MP0003699_abnormal_female_reproductive0.84670811
73MP0000049_abnormal_middle_ear0.84352677
74MP0000432_abnormal_head_morphology0.82520338
75MP0005499_abnormal_olfactory_system0.81762114
76MP0005394_taste/olfaction_phenotype0.81762114
77MP0003567_abnormal_fetal_cardiomyocyte0.80672102
78MP0003123_paternal_imprinting0.80588035
79MP0003136_yellow_coat_color0.79408280
80MP0003121_genomic_imprinting0.75637368
81MP0005501_abnormal_skin_physiology0.75143510
82MP0000490_abnormal_crypts_of0.74287110
83MP0004185_abnormal_adipocyte_glucose0.74256956
84MP0005384_cellular_phenotype0.73339189
85MP0003942_abnormal_urinary_system0.73175980
86MP0002161_abnormal_fertility/fecundity0.71966563
87MP0000647_abnormal_sebaceous_gland0.70390006
88MP0006035_abnormal_mitochondrial_morpho0.68843178
89MP0005621_abnormal_cell_physiology0.68251961
90MP0001119_abnormal_female_reproductive0.68156872
91MP0000579_abnormal_nail_morphology0.67671902
92MP0002160_abnormal_reproductive_system0.67126112
93MP0001299_abnormal_eye_distance/0.63996976
94MP0003943_abnormal_hepatobiliary_system0.63330042
95MP0002114_abnormal_axial_skeleton0.63302822
96MP0004808_abnormal_hematopoietic_stem0.61031267
97MP0009379_abnormal_foot_pigmentation0.60908656
98MP0002081_perinatal_lethality0.59863480
99MP0004272_abnormal_basement_membrane0.59385551
100MP0005257_abnormal_intraocular_pressure0.58947674

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.94498183
2Chromsome breakage (HP:0040012)5.62206930
3Increased nuchal translucency (HP:0010880)4.23817880
4Meckel diverticulum (HP:0002245)3.74750581
5Cortical dysplasia (HP:0002539)3.73614537
6Abnormality of chromosome stability (HP:0003220)3.65936337
7Abnormality of the preputium (HP:0100587)3.57748414
8Aplasia/Hypoplasia of the uvula (HP:0010293)3.54524264
9Abnormality of the ileum (HP:0001549)3.53731253
10Small intestinal stenosis (HP:0012848)3.39845192
11Duodenal stenosis (HP:0100867)3.39845192
12Abnormal lung lobation (HP:0002101)3.34797305
13Volvulus (HP:0002580)3.27079267
14Nephroblastoma (Wilms tumor) (HP:0002667)3.25849606
15Embryonal renal neoplasm (HP:0011794)3.07093363
16Birth length less than 3rd percentile (HP:0003561)3.04137815
17Abnormality of the duodenum (HP:0002246)2.84449386
18Abnormality of the carotid arteries (HP:0005344)2.81871875
19Aplasia/Hypoplasia of the sacrum (HP:0008517)2.78850934
20Reticulocytopenia (HP:0001896)2.75497781
21Myelodysplasia (HP:0002863)2.73510288
22Ectopic kidney (HP:0000086)2.62462386
23Absent radius (HP:0003974)2.57449378
24Proximal placement of thumb (HP:0009623)2.46691144
25Selective tooth agenesis (HP:0001592)2.46370789
26Cafe-au-lait spot (HP:0000957)2.42215930
27Sloping forehead (HP:0000340)2.40815056
28Deviation of the thumb (HP:0009603)2.39499944
29Aplasia involving forearm bones (HP:0009822)2.39054199
30Absent forearm bone (HP:0003953)2.39054199
31Facial hemangioma (HP:0000329)2.32496059
32Hypoplastic pelvis (HP:0008839)2.30418918
33High anterior hairline (HP:0009890)2.27721519
34Duplication of thumb phalanx (HP:0009942)2.26692381
35Triphalangeal thumb (HP:0001199)2.23175488
36Abnormality of the labia minora (HP:0012880)2.21289312
37Choanal atresia (HP:0000453)2.19947001
38Rhabdomyosarcoma (HP:0002859)2.19103203
39Missing ribs (HP:0000921)2.14803903
40Abnormal number of incisors (HP:0011064)2.14667798
41Horseshoe kidney (HP:0000085)2.14541363
42Aplasia/Hypoplasia of the sternum (HP:0006714)2.13368680
43Overlapping toe (HP:0001845)2.12923515
44Ependymoma (HP:0002888)2.12257583
45Abnormality of chromosome segregation (HP:0002916)2.07326653
4611 pairs of ribs (HP:0000878)2.04715003
47Breast hypoplasia (HP:0003187)2.04196091
48Hypoplasia of the capital femoral epiphysis (HP:0003090)2.02888961
49Embryonal neoplasm (HP:0002898)2.02653327
50Arteriovenous malformation (HP:0100026)2.00544650
51Short thumb (HP:0009778)2.00034258
52Clubbing of toes (HP:0100760)1.99546713
53Deep philtrum (HP:0002002)1.97624593
54Multiple enchondromatosis (HP:0005701)1.96552856
55Abnormal gallbladder physiology (HP:0012438)1.92845110
56Cholecystitis (HP:0001082)1.92845110
57Medulloblastoma (HP:0002885)1.89021982
58Neoplasm of the colon (HP:0100273)1.88720618
59Glioma (HP:0009733)1.84452358
60Atresia of the external auditory canal (HP:0000413)1.83450070
61Abnormality of the phalanges of the hallux (HP:0010057)1.82567187
62Colon cancer (HP:0003003)1.82413585
63Absent thumb (HP:0009777)1.82289707
64Abnormality of the fetal cardiovascular system (HP:0010948)1.82258311
65Abnormal umbilical cord blood vessels (HP:0011403)1.82258311
66Single umbilical artery (HP:0001195)1.82258311
67Absent epiphyses (HP:0010577)1.81654231
68Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.81654231
69Abnormality of the septum pellucidum (HP:0007375)1.80578544
70Facial cleft (HP:0002006)1.79622190
71Abnormality of cochlea (HP:0000375)1.79295534
72Abnormality of the astrocytes (HP:0100707)1.77261704
73Astrocytoma (HP:0009592)1.77261704
74Abnormality of the umbilical cord (HP:0010881)1.77123639
75Capillary hemangiomas (HP:0005306)1.74194817
76Oligodactyly (HP:0012165)1.73312551
77Absent septum pellucidum (HP:0001331)1.73278622
78Microglossia (HP:0000171)1.73048710
79Patellar aplasia (HP:0006443)1.71826762
80Impulsivity (HP:0100710)1.69199200
81Broad distal phalanx of finger (HP:0009836)1.67564593
82Septo-optic dysplasia (HP:0100842)1.66317119
83Overriding aorta (HP:0002623)1.65956690
84Abnormality of glycolysis (HP:0004366)1.65511208
85High pitched voice (HP:0001620)1.65456957
86Abnormality of the calcaneus (HP:0008364)1.62237592
87Hyperacusis (HP:0010780)1.61373560
88Tracheoesophageal fistula (HP:0002575)1.60921354
89Oligodactyly (hands) (HP:0001180)1.59842077
90Squamous cell carcinoma (HP:0002860)1.59283831
91Aplasia/Hypoplasia of the patella (HP:0006498)1.57652043
92Microvesicular hepatic steatosis (HP:0001414)1.55001001
93Insomnia (HP:0100785)1.53631763
94Uterine leiomyosarcoma (HP:0002891)1.53489253
95Leiomyosarcoma (HP:0100243)1.53489253
96Obsessive-compulsive behavior (HP:0000722)1.53360776
97Duplicated collecting system (HP:0000081)1.53276729
98Progressive external ophthalmoplegia (HP:0000590)1.52402008
99Progressive muscle weakness (HP:0003323)1.51180962
100Secondary amenorrhea (HP:0000869)1.50602309

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.35164828
2TTK4.34273639
3CDC73.97763520
4NEK13.46935825
5WEE13.28008670
6PBK2.67256549
7SRPK12.65121848
8NEK22.55088793
9PLK42.49797360
10PLK32.39434983
11BRSK22.34357166
12TSSK62.23376609
13EIF2AK12.20766455
14PLK12.09334408
15VRK21.99708606
16BRSK11.96394808
17CHEK21.75294158
18AURKB1.74403295
19ZAK1.72458413
20CDK121.53985294
21MKNK11.49139521
22ATR1.38335886
23CCNB11.37157227
24CDK71.32844846
25BRAF1.32338189
26PNCK1.31604826
27MKNK21.30415283
28MAP3K101.29519964
29AURKA1.28689143
30CHEK11.24382097
31MST1R1.23882212
32MAP3K81.23544992
33STK101.21916266
34SMG11.21045645
35EIF2AK31.12759447
36TAF11.11355006
37STK31.11018264
38VRK11.09939853
39STK41.06062013
40MET1.03678389
41CDK80.95858902
42LATS10.92712606
43EIF2AK20.92357999
44ATM0.91011061
45MELK0.90477024
46BRD40.89812779
47TRIM280.88018167
48NME20.87697415
49EEF2K0.86762783
50RPS6KB20.83644467
51CDK10.81794891
52CLK10.76490347
53PAK40.75527730
54SCYL20.73806133
55LATS20.72728756
56ERBB40.71459500
57STK160.70683565
58CDK20.68970656
59MST40.67920002
60CDK40.67642126
61EPHA20.65507101
62NUAK10.62650046
63MAP3K90.62622401
64PASK0.54995746
65ICK0.52754415
66CDK90.52749804
67RPS6KA40.50938381
68PRKCI0.49695004
69ARAF0.49204745
70ALK0.48024967
71PAK10.46961319
72CDK180.46818284
73NME10.46653424
74CDK150.45857981
75CDK11A0.45462627
76IRAK30.44584107
77KSR10.44076539
78CSNK1E0.41542880
79CSNK2A20.41230815
80PTK20.40122342
81MTOR0.39628519
82RAF10.39343381
83AKT20.39028754
84CSNK2A10.38710382
85CDK60.38462386
86CAMK1G0.37819609
87CDK140.36943120
88TRIB30.35898735
89FGFR10.35247063
90PRKDC0.34987731
91DYRK30.34012599
92PDK20.30458047
93TNIK0.29704850
94PLK20.29635844
95DMPK0.28431231
96PDGFRA0.25192064
97CDK30.25110767
98CAMK1D0.24969433
99MAPK140.23452291
100MARK30.21809795

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.99948963
2Mismatch repair_Homo sapiens_hsa034304.36587494
3Cell cycle_Homo sapiens_hsa041103.74141327
4Non-homologous end-joining_Homo sapiens_hsa034503.10605405
5Homologous recombination_Homo sapiens_hsa034403.07370635
6Base excision repair_Homo sapiens_hsa034103.04449386
7Fanconi anemia pathway_Homo sapiens_hsa034602.80797085
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.74744349
9Nucleotide excision repair_Homo sapiens_hsa034202.69220504
10Spliceosome_Homo sapiens_hsa030402.68746879
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.65787976
12RNA transport_Homo sapiens_hsa030132.65507406
13Proteasome_Homo sapiens_hsa030502.64127292
14One carbon pool by folate_Homo sapiens_hsa006702.04703528
15Oocyte meiosis_Homo sapiens_hsa041141.79256287
16mRNA surveillance pathway_Homo sapiens_hsa030151.76190554
17Basal transcription factors_Homo sapiens_hsa030221.74254439
18Ribosome_Homo sapiens_hsa030101.70392890
19Pyrimidine metabolism_Homo sapiens_hsa002401.66563415
20RNA polymerase_Homo sapiens_hsa030201.64919916
21RNA degradation_Homo sapiens_hsa030181.57476649
22p53 signaling pathway_Homo sapiens_hsa041151.52644227
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.49324615
24Biosynthesis of amino acids_Homo sapiens_hsa012301.46933356
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.46678950
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44264528
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27274501
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17748452
29Pyruvate metabolism_Homo sapiens_hsa006201.11421846
30Thyroid cancer_Homo sapiens_hsa052161.09532438
31Folate biosynthesis_Homo sapiens_hsa007901.00013763
32Carbon metabolism_Homo sapiens_hsa012000.98873212
33Selenocompound metabolism_Homo sapiens_hsa004500.98586006
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97246347
35Purine metabolism_Homo sapiens_hsa002300.96325606
36MicroRNAs in cancer_Homo sapiens_hsa052060.94964257
37Steroid biosynthesis_Homo sapiens_hsa001000.94284192
38Lysine degradation_Homo sapiens_hsa003100.93381645
39Adherens junction_Homo sapiens_hsa045200.92371153
40Hippo signaling pathway_Homo sapiens_hsa043900.91391401
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87371735
42Protein export_Homo sapiens_hsa030600.85617942
43Basal cell carcinoma_Homo sapiens_hsa052170.81556894
44Vitamin B6 metabolism_Homo sapiens_hsa007500.80645252
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80523720
46Pentose phosphate pathway_Homo sapiens_hsa000300.79796557
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74786908
48Viral carcinogenesis_Homo sapiens_hsa052030.73451273
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73287281
50Small cell lung cancer_Homo sapiens_hsa052220.72499977
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.71735409
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68947979
53Colorectal cancer_Homo sapiens_hsa052100.64609174
54TGF-beta signaling pathway_Homo sapiens_hsa043500.64353527
55N-Glycan biosynthesis_Homo sapiens_hsa005100.60432052
56Hedgehog signaling pathway_Homo sapiens_hsa043400.60301399
57Huntingtons disease_Homo sapiens_hsa050160.60079626
58Fatty acid elongation_Homo sapiens_hsa000620.59567986
59Wnt signaling pathway_Homo sapiens_hsa043100.58621363
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57956121
61Prostate cancer_Homo sapiens_hsa052150.55597138
62Glutathione metabolism_Homo sapiens_hsa004800.55279734
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55277230
64Epstein-Barr virus infection_Homo sapiens_hsa051690.53338112
65Chronic myeloid leukemia_Homo sapiens_hsa052200.52371980
66HTLV-I infection_Homo sapiens_hsa051660.51845391
67Bladder cancer_Homo sapiens_hsa052190.49268915
68Alcoholism_Homo sapiens_hsa050340.48014274
69Sulfur relay system_Homo sapiens_hsa041220.47587429
70Propanoate metabolism_Homo sapiens_hsa006400.45592187
71Pancreatic cancer_Homo sapiens_hsa052120.45219657
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45042615
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41355099
74Systemic lupus erythematosus_Homo sapiens_hsa053220.38144402
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37711375
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37205193
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33787604
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32699664
79Melanoma_Homo sapiens_hsa052180.32428746
80Endometrial cancer_Homo sapiens_hsa052130.31185215
81Tight junction_Homo sapiens_hsa045300.31133143
82Non-small cell lung cancer_Homo sapiens_hsa052230.30288150
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29401508
84Parkinsons disease_Homo sapiens_hsa050120.29104769
85Proteoglycans in cancer_Homo sapiens_hsa052050.28574988
86Pathways in cancer_Homo sapiens_hsa052000.27417436
87Arginine and proline metabolism_Homo sapiens_hsa003300.24320958
88Metabolic pathways_Homo sapiens_hsa011000.23970941
89Fructose and mannose metabolism_Homo sapiens_hsa000510.22762426
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22126377
91Galactose metabolism_Homo sapiens_hsa000520.21883584
92Gap junction_Homo sapiens_hsa045400.20452955
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20099667
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.19917132
95Glioma_Homo sapiens_hsa052140.18935034
96Hepatitis B_Homo sapiens_hsa051610.16690875
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.16440774
98Apoptosis_Homo sapiens_hsa042100.16369590
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.15143108
100Shigellosis_Homo sapiens_hsa051310.11781698

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