KIF4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is an intronless retrocopy of kinesin family member 4A. The protein encoded by this gene is a microtubule-based motor protein that plays vital roles in anaphase spindle dynamics and cytokinesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)5.86088924
2CENP-A containing nucleosome assembly (GO:0034080)5.81336073
3mitotic metaphase plate congression (GO:0007080)5.31642622
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.29539860
5kinetochore organization (GO:0051383)5.08950901
6protein localization to kinetochore (GO:0034501)5.01909019
7histone exchange (GO:0043486)4.95554855
8kinetochore assembly (GO:0051382)4.84505181
9metaphase plate congression (GO:0051310)4.73884926
10DNA ligation (GO:0006266)4.55778309
11establishment of integrated proviral latency (GO:0075713)4.45222923
12ATP synthesis coupled proton transport (GO:0015986)4.44839648
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.44839648
14DNA replication-independent nucleosome assembly (GO:0006336)4.42987500
15DNA replication-independent nucleosome organization (GO:0034724)4.42987500
16telomere maintenance via semi-conservative replication (GO:0032201)4.33436595
17DNA strand elongation involved in DNA replication (GO:0006271)4.30941782
18mitotic sister chromatid segregation (GO:0000070)4.20193573
19proteasome assembly (GO:0043248)4.19014347
20protein localization to chromosome, centromeric region (GO:0071459)4.13630571
21DNA strand elongation (GO:0022616)4.12453266
22establishment of protein localization to mitochondrial membrane (GO:0090151)4.06884371
23DNA replication checkpoint (GO:0000076)4.05705479
24spindle checkpoint (GO:0031577)4.05267285
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.01291041
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.94620678
27chaperone-mediated protein transport (GO:0072321)3.94575130
28sister chromatid segregation (GO:0000819)3.94308320
29anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.92343901
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.91401606
31establishment of chromosome localization (GO:0051303)3.84744062
32negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.84235641
33negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.84235641
34negative regulation of mitotic sister chromatid segregation (GO:0033048)3.84235641
35negative regulation of mitotic sister chromatid separation (GO:2000816)3.84235641
36negative regulation of sister chromatid segregation (GO:0033046)3.84235641
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.81154334
38mitotic recombination (GO:0006312)3.79194390
39negative regulation of chromosome segregation (GO:0051985)3.76585581
40telomere maintenance via recombination (GO:0000722)3.75031388
41mitotic spindle checkpoint (GO:0071174)3.70449382
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.67929662
43exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.67675772
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.61698918
45negative regulation of ligase activity (GO:0051352)3.60278367
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.60278367
47mitotic spindle assembly checkpoint (GO:0007094)3.56470349
48DNA double-strand break processing (GO:0000729)3.55421989
49respiratory electron transport chain (GO:0022904)3.54921287
50spindle assembly checkpoint (GO:0071173)3.54817753
51DNA damage response, detection of DNA damage (GO:0042769)3.50380315
52regulation of mitotic metaphase/anaphase transition (GO:0030071)3.48220351
53regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.48220351
54spliceosomal snRNP assembly (GO:0000387)3.48014775
55establishment of viral latency (GO:0019043)3.46709285
56electron transport chain (GO:0022900)3.46494230
57regulation of chromosome segregation (GO:0051983)3.44046851
58regulation of spindle organization (GO:0090224)3.41682601
59regulation of mitotic sister chromatid segregation (GO:0033047)3.37211555
60regulation of sister chromatid segregation (GO:0033045)3.37211555
61regulation of mitotic sister chromatid separation (GO:0010965)3.37211555
62mitotic chromosome condensation (GO:0007076)3.34593086
63negative regulation of mitosis (GO:0045839)3.34427569
64protein neddylation (GO:0045116)3.32274457
65nucleotide-excision repair, DNA gap filling (GO:0006297)3.26915315
66maturation of SSU-rRNA (GO:0030490)3.25348598
67regulation of mitochondrial translation (GO:0070129)3.24682998
68ATP-dependent chromatin remodeling (GO:0043044)3.22917917
69termination of RNA polymerase III transcription (GO:0006386)3.21065672
70transcription elongation from RNA polymerase III promoter (GO:0006385)3.21065672
71negative regulation of DNA-dependent DNA replication (GO:2000104)3.20846585
72attachment of spindle microtubules to kinetochore (GO:0008608)3.19765194
73ribosomal small subunit assembly (GO:0000028)3.19340744
74DNA topological change (GO:0006265)3.16520673
75protein K6-linked ubiquitination (GO:0085020)3.15344359
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.13402434
77regulation of mitotic spindle checkpoint (GO:1903504)3.13402434
78microtubule depolymerization (GO:0007019)3.13318470
79signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.13316713
80signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.13316713
81signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.13316713
82positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.13092943
83telomere maintenance via telomere lengthening (GO:0010833)3.11877695
84DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.10127521
85translational termination (GO:0006415)3.09077784
86viral transcription (GO:0019083)3.08777476
87intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06140675
88signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.06140675
89regulation of helicase activity (GO:0051095)3.02223840
90signal transduction involved in DNA damage checkpoint (GO:0072422)3.01982379
91signal transduction involved in DNA integrity checkpoint (GO:0072401)3.01982379
92signal transduction involved in cell cycle checkpoint (GO:0072395)3.00781582
93purine nucleobase biosynthetic process (GO:0009113)2.99668061
94positive regulation of ligase activity (GO:0051351)2.98906644
95regulation of ubiquitin-protein transferase activity (GO:0051438)2.98785407
96mitochondrial respiratory chain complex assembly (GO:0033108)2.97732855
97protein complex biogenesis (GO:0070271)2.96686866
98chromosome segregation (GO:0007059)2.94944192
99IMP biosynthetic process (GO:0006188)2.94748707
100mitotic G2/M transition checkpoint (GO:0044818)2.94578436

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.64159681
2E2F7_22180533_ChIP-Seq_HELA_Human5.50021918
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.07983948
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.78984606
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.06610049
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.95879288
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.91663322
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.77043799
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.61195943
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.32145028
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.15311376
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.04337983
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.69392887
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.68680756
15AR_21909140_ChIP-Seq_LNCAP_Human2.63115442
16ELK1_19687146_ChIP-ChIP_HELA_Human2.51992531
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.50586717
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.34825408
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30483461
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21968436
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15560291
22VDR_23849224_ChIP-Seq_CD4+_Human2.07818130
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.06363452
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05167981
25FOXP3_21729870_ChIP-Seq_TREG_Human2.00266843
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.98081874
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97904858
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90085462
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89479992
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.86669745
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84123508
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80751424
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.76956546
34TTF2_22483619_ChIP-Seq_HELA_Human1.76780868
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73666317
36MYC_18940864_ChIP-ChIP_HL60_Human1.73315941
37POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.69411633
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.69387845
39XRN2_22483619_ChIP-Seq_HELA_Human1.68047432
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66161680
41DCP1A_22483619_ChIP-Seq_HELA_Human1.65054805
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62954865
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62563528
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61269782
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.59801444
46EWS_26573619_Chip-Seq_HEK293_Human1.59266430
47VDR_22108803_ChIP-Seq_LS180_Human1.57577681
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52391648
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.50846506
50NANOG_16153702_ChIP-ChIP_HESCs_Human1.47943821
51GABP_19822575_ChIP-Seq_HepG2_Human1.42082715
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41683190
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40797450
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38816954
55FUS_26573619_Chip-Seq_HEK293_Human1.36667903
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35462182
57SOX2_16153702_ChIP-ChIP_HESCs_Human1.35062806
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28536532
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27460087
60ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27218673
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.25948263
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.19957860
63ZNF274_21170338_ChIP-Seq_K562_Hela1.16457426
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10149910
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08476533
66TP63_19390658_ChIP-ChIP_HaCaT_Human0.95988522
67ELK1_22589737_ChIP-Seq_MCF10A_Human0.95972065
68PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93581907
69TAF15_26573619_Chip-Seq_HEK293_Human0.92958023
70* P300_19829295_ChIP-Seq_ESCs_Human0.92798589
71CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90311985
72POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87213571
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86877282
74NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86028682
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85760396
76IRF1_19129219_ChIP-ChIP_H3396_Human0.84894083
77CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83270876
78SOX17_20123909_ChIP-Seq_XEN_Mouse0.82700395
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82484871
80PCGF2_27294783_Chip-Seq_NPCs_Mouse0.82014386
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81208529
82KDM5A_27292631_Chip-Seq_BREAST_Human0.80268723
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.76582167
84ZFX_18555785_ChIP-Seq_MESCs_Mouse0.75957931
85TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75885520
86* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.75677689
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.73611858
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.71137565
89IGF1R_20145208_ChIP-Seq_DFB_Human0.70457118
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.70445432
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.69172390
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.69030439
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.68401504
94KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.67869996
95KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.67869996
96KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.67869996
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.66832586
98TP53_22573176_ChIP-Seq_HFKS_Human0.66637337
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.65324340
100ERG_20887958_ChIP-Seq_HPC-7_Mouse0.64732500

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.29486986
2MP0003693_abnormal_embryo_hatching4.11809963
3MP0008058_abnormal_DNA_repair3.60597562
4MP0004957_abnormal_blastocyst_morpholog3.34900105
5MP0003890_abnormal_embryonic-extraembry3.27096035
6MP0003111_abnormal_nucleus_morphology3.26926388
7MP0003077_abnormal_cell_cycle3.03208888
8MP0009379_abnormal_foot_pigmentation3.02187545
9MP0006292_abnormal_olfactory_placode2.82771066
10MP0008932_abnormal_embryonic_tissue2.82319709
11MP0001293_anophthalmia2.65062136
12MP0008057_abnormal_DNA_replication2.49083782
13MP0002102_abnormal_ear_morphology2.19427503
14MP0002938_white_spotting2.17460804
15MP0003941_abnormal_skin_development2.07228596
16MP0004133_heterotaxia2.06043147
17MP0003718_maternal_effect2.03362449
18MP0010030_abnormal_orbit_morphology2.00628374
19MP0003136_yellow_coat_color1.96638926
20MP0008007_abnormal_cellular_replicative1.91410585
21MP0003283_abnormal_digestive_organ1.89922834
22MP0008789_abnormal_olfactory_epithelium1.84266775
23MP0009697_abnormal_copulation1.83508276
24MP0006072_abnormal_retinal_apoptosis1.79184150
25MP0003119_abnormal_digestive_system1.78491043
26MP0008877_abnormal_DNA_methylation1.77668355
27MP0005499_abnormal_olfactory_system1.69502395
28MP0005394_taste/olfaction_phenotype1.69502395
29MP0001529_abnormal_vocalization1.67170915
30MP0003880_abnormal_central_pattern1.67084591
31MP0003121_genomic_imprinting1.61415144
32MP0002254_reproductive_system_inflammat1.60994383
33MP0002234_abnormal_pharynx_morphology1.51146398
34MP0006035_abnormal_mitochondrial_morpho1.51139791
35MP0001286_abnormal_eye_development1.49106627
36MP0005084_abnormal_gallbladder_morpholo1.43673007
37MP0003937_abnormal_limbs/digits/tail_de1.41063126
38MP0001485_abnormal_pinna_reflex1.40183137
39MP0003786_premature_aging1.38330420
40MP0003315_abnormal_perineum_morphology1.29031266
41MP0002085_abnormal_embryonic_tissue1.24512560
42MP0002736_abnormal_nociception_after1.23879033
43MP0002111_abnormal_tail_morphology1.23641112
44MP0001672_abnormal_embryogenesis/_devel1.19412142
45MP0005380_embryogenesis_phenotype1.19412142
46MP0003186_abnormal_redox_activity1.19371746
47MP0002233_abnormal_nose_morphology1.15105517
48MP0001697_abnormal_embryo_size1.14280841
49MP0006036_abnormal_mitochondrial_physio1.14184281
50MP0000049_abnormal_middle_ear1.13835954
51MP0000350_abnormal_cell_proliferation1.12126677
52MP0002084_abnormal_developmental_patter1.10215748
53MP0003122_maternal_imprinting1.09884688
54MP0002210_abnormal_sex_determination1.08581601
55MP0003567_abnormal_fetal_cardiomyocyte1.08450278
56MP0001730_embryonic_growth_arrest1.07945035
57MP0003123_paternal_imprinting1.03228304
58MP0002751_abnormal_autonomic_nervous1.01625348
59MP0001929_abnormal_gametogenesis0.99287050
60MP0002697_abnormal_eye_size0.96700649
61MP0005253_abnormal_eye_physiology0.95604845
62MP0001145_abnormal_male_reproductive0.95165251
63MP0000566_synostosis0.93090085
64MP0000653_abnormal_sex_gland0.92888150
65MP0001346_abnormal_lacrimal_gland0.90961009
66MP0000537_abnormal_urethra_morphology0.89719087
67MP0005391_vision/eye_phenotype0.89026268
68MP0003984_embryonic_growth_retardation0.88266728
69MP0002080_prenatal_lethality0.88239729
70MP0003385_abnormal_body_wall0.88078274
71MP0002088_abnormal_embryonic_growth/wei0.86112094
72MP0002653_abnormal_ependyma_morphology0.86046407
73MP0003787_abnormal_imprinting0.85602108
74MP0001984_abnormal_olfaction0.83341166
75MP0004142_abnormal_muscle_tone0.81273136
76MP0005377_hearing/vestibular/ear_phenot0.81213362
77MP0003878_abnormal_ear_physiology0.81213362
78MP0003861_abnormal_nervous_system0.81069992
79MP0003011_delayed_dark_adaptation0.79718417
80MP0004215_abnormal_myocardial_fiber0.76575792
81MP0000358_abnormal_cell_content/0.76526008
82MP0009672_abnormal_birth_weight0.75456411
83MP0005551_abnormal_eye_electrophysiolog0.75291831
84MP0000313_abnormal_cell_death0.74553915
85MP0000428_abnormal_craniofacial_morphol0.74120268
86MP0000579_abnormal_nail_morphology0.72589674
87MP0003755_abnormal_palate_morphology0.72575576
88MP0002277_abnormal_respiratory_mucosa0.72119355
89MP0001188_hyperpigmentation0.71939791
90MP0003938_abnormal_ear_development0.71110296
91MP0000647_abnormal_sebaceous_gland0.70812967
92MP0002282_abnormal_trachea_morphology0.70465726
93MP0000631_abnormal_neuroendocrine_gland0.68797738
94MP0006276_abnormal_autonomic_nervous0.68247641
95MP0003698_abnormal_male_reproductive0.67818909
96MP0003137_abnormal_impulse_conducting0.66396106
97MP0002092_abnormal_eye_morphology0.66338894
98MP0001727_abnormal_embryo_implantation0.65639657
99MP0001119_abnormal_female_reproductive0.65021613
100MP0002160_abnormal_reproductive_system0.64045832

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.62567095
2Acute encephalopathy (HP:0006846)4.01595856
3Abnormal mitochondria in muscle tissue (HP:0008316)3.99661196
4Increased hepatocellular lipid droplets (HP:0006565)3.86739304
5Mitochondrial inheritance (HP:0001427)3.80798965
6Colon cancer (HP:0003003)3.79417053
7Progressive macrocephaly (HP:0004481)3.70106330
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.67896246
9Lipid accumulation in hepatocytes (HP:0006561)3.57640672
10Abnormality of the labia minora (HP:0012880)3.48077287
11Increased CSF lactate (HP:0002490)3.43261003
12Chromsome breakage (HP:0040012)3.34535768
13Hepatocellular necrosis (HP:0001404)3.30188241
14Meckel diverticulum (HP:0002245)3.15985472
15Reticulocytopenia (HP:0001896)3.10917909
16Aplasia/Hypoplasia of the uvula (HP:0010293)3.07930810
17Cerebral edema (HP:0002181)3.06104308
18Aplasia/Hypoplasia of the sacrum (HP:0008517)2.99121676
19Renal Fanconi syndrome (HP:0001994)2.98876991
20Abnormality of the ileum (HP:0001549)2.95615334
21Birth length less than 3rd percentile (HP:0003561)2.91652689
22Abnormal lung lobation (HP:0002101)2.83497267
23Septo-optic dysplasia (HP:0100842)2.81843983
24Intestinal atresia (HP:0011100)2.77453799
25Abnormality of chromosome stability (HP:0003220)2.72707114
26Exertional dyspnea (HP:0002875)2.71335830
27Hepatic necrosis (HP:0002605)2.68920561
28Abnormality of the duodenum (HP:0002246)2.61810986
29Abnormality of the preputium (HP:0100587)2.59292007
30Duodenal stenosis (HP:0100867)2.57469564
31Small intestinal stenosis (HP:0012848)2.57469564
32Oligodactyly (hands) (HP:0001180)2.56476854
33Triphalangeal thumb (HP:0001199)2.50568255
34Congenital, generalized hypertrichosis (HP:0004540)2.47970223
35Volvulus (HP:0002580)2.47541238
36Pancreatic fibrosis (HP:0100732)2.42111482
37True hermaphroditism (HP:0010459)2.37159692
38Pancreatic cysts (HP:0001737)2.35893211
39Absent radius (HP:0003974)2.33580709
40Hypoplastic pelvis (HP:0008839)2.32019995
41Absent septum pellucidum (HP:0001331)2.30289323
42Respiratory difficulties (HP:0002880)2.30142362
43Anophthalmia (HP:0000528)2.29189697
44Esophageal atresia (HP:0002032)2.29174157
45Macrocytic anemia (HP:0001972)2.27698893
46Abnormal number of incisors (HP:0011064)2.25875447
47Leukodystrophy (HP:0002415)2.24250489
48Methylmalonic acidemia (HP:0002912)2.24047318
49Absent forearm bone (HP:0003953)2.22160222
50Aplasia involving forearm bones (HP:0009822)2.22160222
51Optic disc pallor (HP:0000543)2.20889631
52Abnormal number of erythroid precursors (HP:0012131)2.18981323
53Congenital malformation of the right heart (HP:0011723)2.17998769
54Double outlet right ventricle (HP:0001719)2.17998769
55Abnormality of midbrain morphology (HP:0002418)2.16321198
56Molar tooth sign on MRI (HP:0002419)2.16321198
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.16039435
58Horseshoe kidney (HP:0000085)2.13425644
59Anencephaly (HP:0002323)2.12129962
60Ectopic kidney (HP:0000086)2.11321489
61Decreased activity of mitochondrial respiratory chain (HP:0008972)2.10576695
62Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.10576695
63Cleft eyelid (HP:0000625)2.10327793
64Sloping forehead (HP:0000340)2.08833088
65Increased serum lactate (HP:0002151)2.08589428
66Respiratory failure (HP:0002878)2.06386470
67Hyperglycinemia (HP:0002154)2.04937102
68Oligodactyly (HP:0012165)2.04309497
69Gastrointestinal atresia (HP:0002589)2.04232848
70Hemivertebrae (HP:0002937)2.02755691
71Abnormality of cells of the erythroid lineage (HP:0012130)2.02684179
72Bilateral microphthalmos (HP:0007633)2.01747941
73Abnormality of renal resorption (HP:0011038)2.00271619
74Supernumerary spleens (HP:0009799)2.00136865
75Degeneration of anterior horn cells (HP:0002398)1.99424332
76Abnormality of the anterior horn cell (HP:0006802)1.99424332
77Lactic acidosis (HP:0003128)1.97467302
78Abnormality of the septum pellucidum (HP:0007375)1.96740947
79Bile duct proliferation (HP:0001408)1.95465760
80Abnormal biliary tract physiology (HP:0012439)1.95465760
81Hypoplastic female external genitalia (HP:0012815)1.94085989
82Ependymoma (HP:0002888)1.93580671
83Glioma (HP:0009733)1.93258692
84Methylmalonic aciduria (HP:0012120)1.91773028
85Preaxial hand polydactyly (HP:0001177)1.86623962
86Cortical dysplasia (HP:0002539)1.86524158
87Exercise intolerance (HP:0003546)1.85969735
88Medulloblastoma (HP:0002885)1.85816855
89Holoprosencephaly (HP:0001360)1.84697036
90Aplasia/Hypoplasia of the tongue (HP:0010295)1.83586456
91Small hand (HP:0200055)1.83045457
92Sclerocornea (HP:0000647)1.82232339
93Pancytopenia (HP:0001876)1.82089112
94Rhabdomyosarcoma (HP:0002859)1.81925410
95Increased intramyocellular lipid droplets (HP:0012240)1.81900133
96Nephronophthisis (HP:0000090)1.81809859
97Pendular nystagmus (HP:0012043)1.81633695
98Cerebral hypomyelination (HP:0006808)1.79965110
99Multiple enchondromatosis (HP:0005701)1.79610534
100Abnormality of serum amino acid levels (HP:0003112)1.79042462

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.17438180
2VRK24.28699844
3CDC73.59174390
4TTK3.29035856
5NEK12.96631700
6PBK2.76093921
7ZAK2.70060681
8PLK32.64830672
9PLK42.61928823
10WEE12.43760254
11TNIK2.42924119
12VRK12.36773881
13BRSK22.32792155
14SRPK12.28913408
15STK162.18920078
16BMPR1B2.04290974
17WNK32.02441091
18TRIM282.01008652
19PLK11.94065901
20MKNK21.84615338
21NUAK11.80426190
22MST41.79012703
23TAF11.71471914
24ACVR1B1.70449646
25MKNK11.69174446
26NME11.58143996
27TSSK61.57368036
28ERBB41.41760059
29EIF2AK31.38226215
30NEK21.32367335
31EIF2AK11.31216477
32BRSK11.30533369
33AURKB1.27081644
34PNCK1.26178460
35STK101.18105687
36CHEK21.16551455
37CCNB11.08651564
38PDK21.05842401
39BRAF1.05295609
40DYRK20.99217547
41ATR0.98408116
42STK40.97865046
43UHMK10.88536290
44MAP4K20.80114017
45PLK20.79736512
46TGFBR10.76957271
47MAP3K40.76934228
48GRK10.76341764
49EIF2AK20.73600207
50AURKA0.70103099
51CDK70.64744072
52DYRK30.62175729
53CDK30.61472608
54CHEK10.61357559
55CASK0.60753449
56CSNK1G10.60552504
57CSNK2A10.59370092
58PASK0.59148533
59NME20.59107552
60BCR0.58719065
61ATM0.58388479
62TIE10.57269740
63ARAF0.56242877
64STK38L0.55019182
65NLK0.49909519
66CSNK2A20.48693773
67MAP3K80.48092323
68MELK0.47716713
69CSNK1G30.46250068
70CDK10.43330022
71PRKCG0.42992972
72ADRBK10.42451937
73KDR0.41072148
74STK30.39516502
75MINK10.39493986
76EPHA40.38907522
77CSNK1G20.34499556
78BRD40.32725847
79PAK10.32449325
80CDK20.32257824
81ADRBK20.31397382
82CSNK1E0.30538872
83OXSR10.30233238
84PRKDC0.29124393
85ALK0.29114022
86MAP3K90.29048462
87LRRK20.28650854
88MARK30.28276411
89FGFR10.28235919
90CLK10.27391301
91ABL20.26839697
92WNK40.26521568
93CSNK1A10.22483171
94CDK180.21724941
95RPS6KA40.21530003
96CSNK1A1L0.21240265
97GRK70.21063754
98EPHB20.20856293
99INSRR0.20699325
100ERBB30.20591773

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.28249711
2Mismatch repair_Homo sapiens_hsa034304.01909566
3DNA replication_Homo sapiens_hsa030304.00272565
4Ribosome_Homo sapiens_hsa030103.54973902
5Oxidative phosphorylation_Homo sapiens_hsa001903.42982775
6RNA polymerase_Homo sapiens_hsa030203.17884124
7Parkinsons disease_Homo sapiens_hsa050123.09182249
8Homologous recombination_Homo sapiens_hsa034402.96911737
9Non-homologous end-joining_Homo sapiens_hsa034502.57085419
10Protein export_Homo sapiens_hsa030602.35030303
11Fanconi anemia pathway_Homo sapiens_hsa034602.34819475
12Huntingtons disease_Homo sapiens_hsa050162.32613056
13Base excision repair_Homo sapiens_hsa034102.31604104
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.27355085
15Spliceosome_Homo sapiens_hsa030402.25911063
16Nucleotide excision repair_Homo sapiens_hsa034202.09817711
17Cell cycle_Homo sapiens_hsa041102.04079330
18Alzheimers disease_Homo sapiens_hsa050101.98323078
19RNA transport_Homo sapiens_hsa030131.88596715
20Pyrimidine metabolism_Homo sapiens_hsa002401.79983381
21One carbon pool by folate_Homo sapiens_hsa006701.78236617
22RNA degradation_Homo sapiens_hsa030181.77426338
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59668904
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59437555
25Basal transcription factors_Homo sapiens_hsa030221.55883114
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46852697
27Pyruvate metabolism_Homo sapiens_hsa006201.38464635
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32539209
29Propanoate metabolism_Homo sapiens_hsa006401.32116096
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30613487
31Purine metabolism_Homo sapiens_hsa002301.28583174
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24158917
33Cardiac muscle contraction_Homo sapiens_hsa042601.22198267
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.20591217
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20095884
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17065210
37Glutathione metabolism_Homo sapiens_hsa004801.03170422
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00781947
39Oocyte meiosis_Homo sapiens_hsa041140.97702643
40p53 signaling pathway_Homo sapiens_hsa041150.97453007
41Basal cell carcinoma_Homo sapiens_hsa052170.95446496
42Phototransduction_Homo sapiens_hsa047440.94960601
43Steroid biosynthesis_Homo sapiens_hsa001000.92369727
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85162953
45Selenocompound metabolism_Homo sapiens_hsa004500.78835919
46Folate biosynthesis_Homo sapiens_hsa007900.78556160
47mRNA surveillance pathway_Homo sapiens_hsa030150.76762613
48Hedgehog signaling pathway_Homo sapiens_hsa043400.75792100
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69917256
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67843351
51Metabolic pathways_Homo sapiens_hsa011000.66771176
52Carbon metabolism_Homo sapiens_hsa012000.65921565
53Sulfur relay system_Homo sapiens_hsa041220.60710382
54Butanoate metabolism_Homo sapiens_hsa006500.59138147
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58261032
56Fatty acid elongation_Homo sapiens_hsa000620.57621899
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56659297
58Biosynthesis of amino acids_Homo sapiens_hsa012300.56610296
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53518545
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50617893
61beta-Alanine metabolism_Homo sapiens_hsa004100.48639186
62Peroxisome_Homo sapiens_hsa041460.46156229
63Caffeine metabolism_Homo sapiens_hsa002320.43754195
64Tryptophan metabolism_Homo sapiens_hsa003800.43466499
65TGF-beta signaling pathway_Homo sapiens_hsa043500.42383181
66Olfactory transduction_Homo sapiens_hsa047400.40400635
67Vitamin B6 metabolism_Homo sapiens_hsa007500.36858416
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36548223
69Epstein-Barr virus infection_Homo sapiens_hsa051690.36398949
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36126218
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34191674
72Vitamin digestion and absorption_Homo sapiens_hsa049770.33539441
73Hippo signaling pathway_Homo sapiens_hsa043900.32900861
74Fatty acid degradation_Homo sapiens_hsa000710.32886800
75Wnt signaling pathway_Homo sapiens_hsa043100.32261000
76Arginine and proline metabolism_Homo sapiens_hsa003300.32204494
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.30725175
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29704746
79Nitrogen metabolism_Homo sapiens_hsa009100.29642345
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26703100
81Fat digestion and absorption_Homo sapiens_hsa049750.26088877
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.25899663
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24662147
84Retinol metabolism_Homo sapiens_hsa008300.24560215
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23765627
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23248119
87Linoleic acid metabolism_Homo sapiens_hsa005910.22807277
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22635375
89Chemical carcinogenesis_Homo sapiens_hsa052040.19321668
90Systemic lupus erythematosus_Homo sapiens_hsa053220.18623646
91Ether lipid metabolism_Homo sapiens_hsa005650.17914696
92Sulfur metabolism_Homo sapiens_hsa009200.15753418
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15501343
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15019093
95Collecting duct acid secretion_Homo sapiens_hsa049660.14661089
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14081385
97N-Glycan biosynthesis_Homo sapiens_hsa005100.13244046
98Fatty acid metabolism_Homo sapiens_hsa012120.12538456
99Nicotine addiction_Homo sapiens_hsa050330.12204016
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.11835331

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