KIF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine deoxyribonucleotide catabolic process (GO:0009223)7.75146135
2central nervous system myelination (GO:0022010)7.62124112
3axon ensheathment in central nervous system (GO:0032291)7.62124112
4base-excision repair, AP site formation (GO:0006285)7.22791232
5cellular glucuronidation (GO:0052695)6.92857365
6glucuronate metabolic process (GO:0019585)6.80550827
7uronic acid metabolic process (GO:0006063)6.80550827
8pyrimidine nucleotide catabolic process (GO:0006244)6.44958623
9fatty acid elongation (GO:0030497)6.20960804
10cilium movement (GO:0003341)5.97330291
11lens morphogenesis in camera-type eye (GO:0002089)5.66557003
12axonemal dynein complex assembly (GO:0070286)5.16787136
13heart valve formation (GO:0003188)4.99422364
14epithelial cilium movement (GO:0003351)4.79791182
15positive regulation of gastrulation (GO:2000543)4.75706760
16behavioral response to nicotine (GO:0035095)4.74172582
17axoneme assembly (GO:0035082)4.69097405
18lens fiber cell differentiation (GO:0070306)4.67723699
19myelination (GO:0042552)4.62747162
20axon ensheathment (GO:0008366)4.61174885
21ensheathment of neurons (GO:0007272)4.61174885
22negative regulation of chondrocyte differentiation (GO:0032331)4.55083214
23cilium or flagellum-dependent cell motility (GO:0001539)4.54995048
24presynaptic membrane assembly (GO:0097105)4.23695511
25enteric nervous system development (GO:0048484)4.10647593
26pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.09429198
27presynaptic membrane organization (GO:0097090)4.07607017
28detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.00108109
29long-chain fatty acid biosynthetic process (GO:0042759)3.99745092
30ventricular system development (GO:0021591)3.99272917
31asymmetric protein localization (GO:0008105)3.90553732
32ear development (GO:0043583)3.88500671
33response to pheromone (GO:0019236)3.87821648
34fucose catabolic process (GO:0019317)3.83565988
35L-fucose metabolic process (GO:0042354)3.83565988
36L-fucose catabolic process (GO:0042355)3.83565988
37regulation of cilium movement (GO:0003352)3.79528562
38negative regulation of inclusion body assembly (GO:0090084)3.78980844
39apical protein localization (GO:0045176)3.70705160
40indolalkylamine metabolic process (GO:0006586)3.68126826
41tryptophan catabolic process (GO:0006569)3.65680527
42indole-containing compound catabolic process (GO:0042436)3.65680527
43indolalkylamine catabolic process (GO:0046218)3.65680527
44oligodendrocyte differentiation (GO:0048709)3.55540769
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.52421251
46DNA deamination (GO:0045006)3.50561818
47myelin maintenance (GO:0043217)3.48782354
48negative regulation of protein localization to cell surface (GO:2000009)3.44657411
49kynurenine metabolic process (GO:0070189)3.37741172
50detection of light stimulus involved in sensory perception (GO:0050962)3.36957640
51detection of light stimulus involved in visual perception (GO:0050908)3.36957640
52gamma-aminobutyric acid transport (GO:0015812)3.34892557
53cilium organization (GO:0044782)3.28706104
54water-soluble vitamin biosynthetic process (GO:0042364)3.25627006
55retinal cone cell development (GO:0046549)3.23948806
56eye photoreceptor cell differentiation (GO:0001754)3.23858980
57photoreceptor cell differentiation (GO:0046530)3.23858980
58piRNA metabolic process (GO:0034587)3.22121864
59negative regulation of cartilage development (GO:0061037)3.19816601
60phenylpropanoid metabolic process (GO:0009698)3.19492992
61tryptophan metabolic process (GO:0006568)3.18667604
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.16776438
63cilium assembly (GO:0042384)3.16628106
64cilium morphogenesis (GO:0060271)3.16436021
65positive regulation of actin filament depolymerization (GO:0030836)3.15640118
66cellular ketone body metabolic process (GO:0046950)3.13774818
67adult feeding behavior (GO:0008343)3.12688740
68neural tube formation (GO:0001841)3.10874025
69membrane assembly (GO:0071709)3.10406005
70regulation of action potential (GO:0098900)3.08291944
71cholesterol biosynthetic process (GO:0006695)3.02769044
72adaptation of signaling pathway (GO:0023058)3.02681295
73protein localization to cilium (GO:0061512)3.02558036
74positive regulation of macroautophagy (GO:0016239)3.02441832
75protein targeting to vacuole (GO:0006623)3.00977717
76protein targeting to lysosome (GO:0006622)3.00977717
77establishment of protein localization to vacuole (GO:0072666)3.00977717
78keratinocyte development (GO:0003334)2.99582100
79photoreceptor cell maintenance (GO:0045494)2.98652409
80nonmotile primary cilium assembly (GO:0035058)2.97983972
81thalamus development (GO:0021794)2.97152325
82respiratory chain complex IV assembly (GO:0008535)2.96722547
83motile cilium assembly (GO:0044458)2.95772992
84preassembly of GPI anchor in ER membrane (GO:0016254)2.92142654
85neuronal action potential (GO:0019228)2.91170772
86ketone body metabolic process (GO:1902224)2.89840449
87nucleotide transmembrane transport (GO:1901679)2.88434370
88indole-containing compound metabolic process (GO:0042430)2.87771394
89acrosome reaction (GO:0007340)2.86564618
90adhesion of symbiont to host (GO:0044406)2.85986451
91SMAD protein complex assembly (GO:0007183)2.85354526
92reflex (GO:0060004)2.84709246
93deoxyribonucleotide catabolic process (GO:0009264)2.83464597
94negative regulation of mast cell activation (GO:0033004)2.82871312
95peripheral nervous system development (GO:0007422)2.80716419
96protein polyglutamylation (GO:0018095)2.79979862
97behavioral response to ethanol (GO:0048149)2.79823922
98protein complex biogenesis (GO:0070271)2.79090851
99rRNA catabolic process (GO:0016075)2.78043468
100negative regulation of telomere maintenance (GO:0032205)2.76603387
101primary amino compound metabolic process (GO:1901160)2.75925950
102DNA methylation involved in gamete generation (GO:0043046)2.75507707
103mitochondrial respiratory chain complex I assembly (GO:0032981)2.73147181
104NADH dehydrogenase complex assembly (GO:0010257)2.73147181
105mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.73147181
106platelet dense granule organization (GO:0060155)2.72090055
107negative regulation of cytosolic calcium ion concentration (GO:0051481)2.71216529
108reciprocal DNA recombination (GO:0035825)2.70548467
109reciprocal meiotic recombination (GO:0007131)2.70548467
110auditory receptor cell stereocilium organization (GO:0060088)2.70134520
111regulation of lipoprotein metabolic process (GO:0050746)2.69795598
112nephron epithelium morphogenesis (GO:0072088)2.69620552
113nephron tubule morphogenesis (GO:0072078)2.69620552
114regulation of cardiac muscle cell contraction (GO:0086004)2.69525961
115photoreceptor cell development (GO:0042461)2.67750825
116multicellular organism reproduction (GO:0032504)2.66666388
117regulation of microtubule-based movement (GO:0060632)2.66205510
118negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.65443869
119long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.65402962
120protein localization to vacuole (GO:0072665)2.64781729
121protein localization to lysosome (GO:0061462)2.64781729
122positive regulation of digestive system process (GO:0060456)2.64446040
123protein K11-linked deubiquitination (GO:0035871)2.64400103
124dopamine transport (GO:0015872)2.64199019
125deoxyribose phosphate catabolic process (GO:0046386)2.63661782
126left/right axis specification (GO:0070986)2.63278045
127positive regulation of actin cytoskeleton reorganization (GO:2000251)2.62362498
128postsynaptic membrane organization (GO:0001941)2.61961997
129astrocyte development (GO:0014002)2.61445352
130oxygen transport (GO:0015671)2.61334346
131microtubule bundle formation (GO:0001578)2.60384635
132positive regulation of cartilage development (GO:0061036)2.59555663
133neuron cell-cell adhesion (GO:0007158)2.59471019
134regulation of feeding behavior (GO:0060259)2.59399132
135detection of mechanical stimulus involved in sensory perception (GO:0050974)2.58703447
136male meiosis I (GO:0007141)2.58153372
137intraciliary transport (GO:0042073)2.58124344
138cytochrome complex assembly (GO:0017004)2.58053610
139sterol biosynthetic process (GO:0016126)2.57885915
140centriole replication (GO:0007099)2.57474147
141flavonoid metabolic process (GO:0009812)2.56997962
142negative regulation of neurotransmitter transport (GO:0051589)2.56253303
143fusion of sperm to egg plasma membrane (GO:0007342)2.55579102
144glycerophospholipid catabolic process (GO:0046475)2.55054907
145GTP biosynthetic process (GO:0006183)2.54016100
146exogenous drug catabolic process (GO:0042738)2.53514385
147positive regulation of glial cell differentiation (GO:0045687)2.53490905
148protein-cofactor linkage (GO:0018065)2.53297713
149establishment of mitochondrion localization (GO:0051654)2.53289528
150sperm motility (GO:0030317)2.52399341
151serotonin metabolic process (GO:0042428)2.52264591
152mitochondrial respiratory chain complex assembly (GO:0033108)2.51574975
153creatine metabolic process (GO:0006600)2.51155131
154regulation of pigment cell differentiation (GO:0050932)2.50381387
155drug catabolic process (GO:0042737)2.49773226
156cellular component assembly involved in morphogenesis (GO:0010927)2.48774843
157kidney morphogenesis (GO:0060993)2.46925978
158response to methylmercury (GO:0051597)2.46045079
159sulfation (GO:0051923)2.45144091
160cornea development in camera-type eye (GO:0061303)2.44577449
161glutathione derivative biosynthetic process (GO:1901687)2.44213249
162glutathione derivative metabolic process (GO:1901685)2.44213249
163benzene-containing compound metabolic process (GO:0042537)2.43529019
164long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.43431960
165cAMP catabolic process (GO:0006198)2.42997556
166amine catabolic process (GO:0009310)2.42714412
167cellular biogenic amine catabolic process (GO:0042402)2.42714412
168regulation of inclusion body assembly (GO:0090083)2.42707632
169spinal cord motor neuron differentiation (GO:0021522)2.41277218
170aspartate family amino acid catabolic process (GO:0009068)2.40856365
171eye photoreceptor cell development (GO:0042462)2.39565666
172cell fate commitment involved in formation of primary germ layer (GO:0060795)2.39385565
173inner ear receptor stereocilium organization (GO:0060122)2.39213600
174neuron recognition (GO:0008038)2.39080356
175polyol catabolic process (GO:0046174)2.38727528
176axonal fasciculation (GO:0007413)2.38682757
177negative regulation of synaptic transmission, GABAergic (GO:0032229)2.38292453
178GPI anchor metabolic process (GO:0006505)2.37958095
179smoothened signaling pathway (GO:0007224)2.37587249
180regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.37558681
181proline transport (GO:0015824)2.37206466
182transmission of nerve impulse (GO:0019226)2.36706425
183positive regulation of protein depolymerization (GO:1901881)2.36351796
184nucleoside diphosphate phosphorylation (GO:0006165)2.35881607
185cellular copper ion homeostasis (GO:0006878)2.35008580
186positive regulation of oligodendrocyte differentiation (GO:0048714)2.33847686
187regulation of glomerular filtration (GO:0003093)2.33819413
188cerebral cortex radially oriented cell migration (GO:0021799)2.32742669

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.21700026
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.56050335
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.37289325
4EZH2_22144423_ChIP-Seq_EOC_Human3.21899209
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.71842221
6IGF1R_20145208_ChIP-Seq_DFB_Human2.41044205
7GBX2_23144817_ChIP-Seq_PC3_Human2.33836485
8CDX2_19796622_ChIP-Seq_MESCs_Mouse2.32918344
9* FUS_26573619_Chip-Seq_HEK293_Human2.12587154
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.12482772
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.10202485
12EED_16625203_ChIP-ChIP_MESCs_Mouse1.90626420
13TAF15_26573619_Chip-Seq_HEK293_Human1.90421044
14EWS_26573619_Chip-Seq_HEK293_Human1.89876552
15RNF2_27304074_Chip-Seq_ESCs_Mouse1.88920477
16EZH2_27304074_Chip-Seq_ESCs_Mouse1.87964382
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86608028
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86280550
19ER_23166858_ChIP-Seq_MCF-7_Human1.85994980
20SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85858871
21SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.84697851
22DROSHA_22980978_ChIP-Seq_HELA_Human1.83713181
23MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82628412
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.80085225
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79829247
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.78295249
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75927097
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74970948
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74559330
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.73002363
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.70178446
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.64714318
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.64714318
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63991932
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63716496
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59975331
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59357464
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59006060
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58597667
40STAT3_23295773_ChIP-Seq_U87_Human1.58110622
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58019709
42CBP_20019798_ChIP-Seq_JUKART_Human1.58019709
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57665123
44BCAT_22108803_ChIP-Seq_LS180_Human1.57087379
45JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54735903
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52877617
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51795331
48REST_21632747_ChIP-Seq_MESCs_Mouse1.51392274
49SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.49678207
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49541797
51TCF4_23295773_ChIP-Seq_U87_Human1.49248013
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49103724
53AR_21572438_ChIP-Seq_LNCaP_Human1.47919741
54AR_25329375_ChIP-Seq_VCAP_Human1.47814195
55TP53_22573176_ChIP-Seq_HFKS_Human1.47236466
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.47081412
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42779418
58* SMAD4_21799915_ChIP-Seq_A2780_Human1.40431508
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39144583
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38576325
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37669319
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37390001
63NANOG_19829295_ChIP-Seq_ESCs_Human1.37076595
64SOX2_19829295_ChIP-Seq_ESCs_Human1.37076595
65* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36743946
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34113930
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31901783
68CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31267711
69TCF4_22108803_ChIP-Seq_LS180_Human1.31126453
70IRF1_19129219_ChIP-ChIP_H3396_Human1.29582992
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27056012
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.26686999
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.26366144
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25967565
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.25967565
76* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24865479
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.23866764
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23537082
79RUNX2_22187159_ChIP-Seq_PCA_Human1.23486443
80LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23466733
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22903087
82SMAD4_21741376_ChIP-Seq_EPCs_Human1.22459799
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22339855
84* EP300_21415370_ChIP-Seq_HL-1_Mouse1.22334856
85FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22045140
86AHR_22903824_ChIP-Seq_MCF-7_Human1.21646831
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.20056109
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.19885127
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19096768
90RING1B_27294783_Chip-Seq_NPCs_Mouse1.18246332
91VDR_22108803_ChIP-Seq_LS180_Human1.18121490
92* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17673324
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.17236246
94GATA3_21878914_ChIP-Seq_MCF-7_Human1.16012734
95RARB_27405468_Chip-Seq_BRAIN_Mouse1.15987357
96MYC_18940864_ChIP-ChIP_HL60_Human1.15813020
97NOTCH1_21737748_ChIP-Seq_TLL_Human1.15231753
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15058867
99CMYC_18555785_Chip-Seq_ESCs_Mouse1.14527117
100AR_20517297_ChIP-Seq_VCAP_Human1.14342763
101POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13392826
102STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13254347
103GATA1_26923725_Chip-Seq_HPCs_Mouse1.13112060
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12835006
105NCOR_22424771_ChIP-Seq_293T_Human1.12785718
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12732007
107RNF2_27304074_Chip-Seq_NSC_Mouse1.12707738
108P53_22387025_ChIP-Seq_ESCs_Mouse1.12617514
109EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12266602
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10421502
111SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.09419542
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.08329053
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07818613
114FLI1_21867929_ChIP-Seq_TH2_Mouse1.06846475
115ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06435430
116NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06372371
117NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05937148
118SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05394664
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05364181
120P300_18555785_Chip-Seq_ESCs_Mouse1.05208473
121ARNT_22903824_ChIP-Seq_MCF-7_Human1.05032739
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04622023
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04622023
124ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03794063
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03067033
126LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01190540
127RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00878680
128CRX_20693478_ChIP-Seq_RETINA_Mouse1.00706273
129E2F1_18555785_Chip-Seq_ESCs_Mouse1.00465241
130NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00395468
131NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00395468
132* P300_19829295_ChIP-Seq_ESCs_Human1.00280688
133* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00109945
134STAT3_18555785_Chip-Seq_ESCs_Mouse0.98966965
135PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98741673
136MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98729406
137ZNF274_21170338_ChIP-Seq_K562_Hela0.97901760
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97500904
139HOXB7_26014856_ChIP-Seq_BT474_Human0.96956229
140CDX2_22108803_ChIP-Seq_LS180_Human0.96800150
141TP53_18474530_ChIP-ChIP_U2OS_Human0.96074872
142SOX2_21211035_ChIP-Seq_LN229_Gbm0.95895361
143AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95760294
144GABP_17652178_ChIP-ChIP_JURKAT_Human0.95736919
145TP53_16413492_ChIP-PET_HCT116_Human0.95377092
146EZH2_27294783_Chip-Seq_NPCs_Mouse0.95253645
147WT1_19549856_ChIP-ChIP_CCG9911_Human0.94726536
148ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.92762003
149P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92658827
150EGR1_19032775_ChIP-ChIP_M12_Human0.92656168
151ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92163976
152SOX2_18555785_Chip-Seq_ESCs_Mouse0.92111836
153TAL1_26923725_Chip-Seq_HPCs_Mouse0.91136552
154AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90305328
155TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90296238

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat7.84676309
2MP0004233_abnormal_muscle_weight4.82235650
3MP0001346_abnormal_lacrimal_gland3.77236032
4MP0003136_yellow_coat_color3.01942656
5MP0002168_other_aberrant_phenotype2.86195746
6MP0008007_abnormal_cellular_replicative2.69496302
7MP0003786_premature_aging2.68398735
8MP0005410_abnormal_fertilization2.56638429
9MP0003385_abnormal_body_wall2.52449082
10MP0003195_calcinosis2.51360679
11MP0000920_abnormal_myelination2.49448147
12MP0000566_synostosis2.37146002
13MP0001968_abnormal_touch/_nociception2.36334852
14MP0002102_abnormal_ear_morphology2.35887309
15MP0006292_abnormal_olfactory_placode2.30115884
16MP0003880_abnormal_central_pattern2.25574974
17MP0005503_abnormal_tendon_morphology2.21161922
18MP0003646_muscle_fatigue2.19343159
19MP0000569_abnormal_digit_pigmentation2.18466324
20MP0002837_dystrophic_cardiac_calcinosis2.15194519
21MP0005171_absent_coat_pigmentation2.14638725
22MP0005646_abnormal_pituitary_gland2.06919300
23MP0008875_abnormal_xenobiotic_pharmacok2.06689936
24MP0004043_abnormal_pH_regulation1.98974845
25MP0004270_analgesia1.96639602
26MP0002877_abnormal_melanocyte_morpholog1.94509036
27MP0005253_abnormal_eye_physiology1.93474567
28MP0005623_abnormal_meninges_morphology1.93467280
29MP0002736_abnormal_nociception_after1.91670943
30MP0004142_abnormal_muscle_tone1.91393492
31MP0008872_abnormal_physiological_respon1.86081467
32MP0000613_abnormal_salivary_gland1.82983097
33MP0001984_abnormal_olfaction1.78082972
34MP0000762_abnormal_tongue_morphology1.76040228
35MP0000579_abnormal_nail_morphology1.75147508
36MP0001986_abnormal_taste_sensitivity1.73374716
37MP0000778_abnormal_nervous_system1.69455746
38MP0000467_abnormal_esophagus_morphology1.66126342
39MP0004133_heterotaxia1.62906366
40MP0000631_abnormal_neuroendocrine_gland1.61612000
41MP0002876_abnormal_thyroid_physiology1.61427577
42MP0002160_abnormal_reproductive_system1.59482118
43MP0009379_abnormal_foot_pigmentation1.58266511
44MP0002735_abnormal_chemical_nociception1.57064434
45MP0003011_delayed_dark_adaptation1.56771338
46MP0006276_abnormal_autonomic_nervous1.56121837
47MP0003690_abnormal_glial_cell1.54418410
48MP0005395_other_phenotype1.52469025
49MP0002653_abnormal_ependyma_morphology1.48655101
50MP0002277_abnormal_respiratory_mucosa1.47564296
51MP0002108_abnormal_muscle_morphology1.47254436
52MP0001486_abnormal_startle_reflex1.41093177
53MP0003950_abnormal_plasma_membrane1.39302265
54MP0004885_abnormal_endolymph1.36564239
55MP0002272_abnormal_nervous_system1.36181763
56MP0003937_abnormal_limbs/digits/tail_de1.34346079
57MP0000427_abnormal_hair_cycle1.32751022
58MP0004859_abnormal_synaptic_plasticity1.32495437
59MP0003828_pulmonary_edema1.32202925
60MP0001970_abnormal_pain_threshold1.32064695
61MP0001501_abnormal_sleep_pattern1.31368163
62MP0001177_atelectasis1.30282117
63MP0002295_abnormal_pulmonary_circulatio1.30161705
64MP0009250_abnormal_appendicular_skeleto1.29905831
65MP0002064_seizures1.28829348
66MP0002133_abnormal_respiratory_system1.28275076
67MP0005388_respiratory_system_phenotype1.28275076
68MP0002557_abnormal_social/conspecific_i1.27015059
69MP0002067_abnormal_sensory_capabilities1.26767152
70MP0010386_abnormal_urinary_bladder1.26493564
71MP0005084_abnormal_gallbladder_morpholo1.24784900
72MP0003329_amyloid_beta_deposits1.23512084
73MP0002090_abnormal_vision1.23412128
74MP0002733_abnormal_thermal_nociception1.23088392
75MP0002938_white_spotting1.22026102
76MP0003941_abnormal_skin_development1.21952437
77MP0005174_abnormal_tail_pigmentation1.21253041
78MP0002098_abnormal_vibrissa_morphology1.21092175
79MP0003718_maternal_effect1.19837697
80MP0004147_increased_porphyrin_level1.18281335
81MP0003787_abnormal_imprinting1.17940380
82MP0001905_abnormal_dopamine_level1.17584996
83MP0004742_abnormal_vestibular_system1.17235977
84MP0002928_abnormal_bile_duct1.14973360
85MP0003635_abnormal_synaptic_transmissio1.13349720
86MP0000372_irregular_coat_pigmentation1.12990155
87MP0009745_abnormal_behavioral_response1.12508348
88MP0009046_muscle_twitch1.12468612
89MP0008789_abnormal_olfactory_epithelium1.10882351
90MP0005386_behavior/neurological_phenoty1.07621769
91MP0004924_abnormal_behavior1.07621769
92MP0008058_abnormal_DNA_repair1.07324544
93MP0002796_impaired_skin_barrier1.06051726
94MP0002138_abnormal_hepatobiliary_system1.05617735
95MP0000647_abnormal_sebaceous_gland1.04679138
96MP0001529_abnormal_vocalization1.03552693
97MP0004145_abnormal_muscle_electrophysio1.01324603
98MP0001485_abnormal_pinna_reflex1.01259016
99MP0010030_abnormal_orbit_morphology1.00978805
100MP0000026_abnormal_inner_ear0.99311454
101MP0003634_abnormal_glial_cell0.98298488
102MP0005377_hearing/vestibular/ear_phenot0.96677591
103MP0003878_abnormal_ear_physiology0.96677591
104MP0001919_abnormal_reproductive_system0.96050100
105MP0001958_emphysema0.95772481
106MP0002234_abnormal_pharynx_morphology0.94941279
107MP0001929_abnormal_gametogenesis0.91075749
108MP0004215_abnormal_myocardial_fiber0.91032948
109MP0008877_abnormal_DNA_methylation0.90826301
110MP0002752_abnormal_somatic_nervous0.90515480
111MP0002095_abnormal_skin_pigmentation0.90343363
112MP0001440_abnormal_grooming_behavior0.88786368
113MP0000383_abnormal_hair_follicle0.88730570
114MP0004272_abnormal_basement_membrane0.86952742
115MP0008995_early_reproductive_senescence0.86683952
116MP0005409_darkened_coat_color0.86471264
117MP0004134_abnormal_chest_morphology0.86002800
118MP0006072_abnormal_retinal_apoptosis0.85183660
119MP0004381_abnormal_hair_follicle0.85054904
120MP0002909_abnormal_adrenal_gland0.83820264
121MP0005508_abnormal_skeleton_morphology0.83714187
122MP0002882_abnormal_neuron_morphology0.83347373
123MP0001293_anophthalmia0.82217590
124MP0001270_distended_abdomen0.82191008
125MP0003137_abnormal_impulse_conducting0.81943831
126MP0002210_abnormal_sex_determination0.81541443
127MP0005551_abnormal_eye_electrophysiolog0.81467054
128MP0000538_abnormal_urinary_bladder0.81324574
129MP0010678_abnormal_skin_adnexa0.80474834
130MP0005389_reproductive_system_phenotype0.79500391
131MP0002229_neurodegeneration0.79145570
132MP0005379_endocrine/exocrine_gland_phen0.79024378
133MP0003890_abnormal_embryonic-extraembry0.78830515
134MP0002734_abnormal_mechanical_nocicepti0.78695471
135MP0002063_abnormal_learning/memory/cond0.78371898
136MP0000230_abnormal_systemic_arterial0.78303219
137MP0005167_abnormal_blood-brain_barrier0.77839031
138MP0008569_lethality_at_weaning0.76943977
139MP0002751_abnormal_autonomic_nervous0.75777188
140MP0002249_abnormal_larynx_morphology0.75302294
141MP0001324_abnormal_eye_pigmentation0.74896579
142MP0003121_genomic_imprinting0.74663535
143MP0000470_abnormal_stomach_morphology0.74513154
144MP0005075_abnormal_melanosome_morpholog0.74228721
145MP0002693_abnormal_pancreas_physiology0.73327371
146MP0000653_abnormal_sex_gland0.72978733
147MP0003252_abnormal_bile_duct0.72889672
148MP0002638_abnormal_pupillary_reflex0.72536923
149MP0001963_abnormal_hearing_physiology0.72068358
150MP0002066_abnormal_motor_capabilities/c0.71924086
151MP0003938_abnormal_ear_development0.70425354
152MP0002572_abnormal_emotion/affect_behav0.69359145
153MP0005408_hypopigmentation0.68176773
154MP0005645_abnormal_hypothalamus_physiol0.68142523
155MP0000955_abnormal_spinal_cord0.67144589
156MP0005197_abnormal_uvea_morphology0.65157581
157MP0002184_abnormal_innervation0.64870254
158MP0005195_abnormal_posterior_eye0.64580259
159MP0008004_abnormal_stomach_pH0.64237799
160MP0003698_abnormal_male_reproductive0.63775221

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.50609557
2Abnormal respiratory motile cilium physiology (HP:0012261)8.08560423
3Abnormal ciliary motility (HP:0012262)7.90260493
4Dynein arm defect of respiratory motile cilia (HP:0012255)6.30364691
5Absent/shortened dynein arms (HP:0200106)6.30364691
6Rhinitis (HP:0012384)6.07224206
7Abnormal respiratory motile cilium morphology (HP:0005938)5.34348043
8Abnormal respiratory epithelium morphology (HP:0012253)5.34348043
9Chronic bronchitis (HP:0004469)4.79020042
10Pancreatic cysts (HP:0001737)4.75131352
11Degeneration of the lateral corticospinal tracts (HP:0002314)4.02815913
12Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.02815913
13Type II lissencephaly (HP:0007260)3.80088078
14Congenital stationary night blindness (HP:0007642)3.78048868
15Split foot (HP:0001839)3.68929593
16Neurofibrillary tangles (HP:0002185)3.37309633
17Medial flaring of the eyebrow (HP:0010747)3.24864411
18Abnormality of the renal cortex (HP:0011035)3.21549622
19Bronchiectasis (HP:0002110)3.17720025
20Aplasia involving bones of the upper limbs (HP:0009823)3.14413722
21Aplasia of the phalanges of the hand (HP:0009802)3.14413722
22Aplasia involving bones of the extremities (HP:0009825)3.14413722
23Cystic liver disease (HP:0006706)3.12095068
24Abnormality of the corticospinal tract (HP:0002492)3.09686219
25Chronic hepatic failure (HP:0100626)3.01463322
26Hyperventilation (HP:0002883)2.91659091
27Abolished electroretinogram (ERG) (HP:0000550)2.90812362
28Bronchomalacia (HP:0002780)2.89436128
29Cerebellar dysplasia (HP:0007033)2.82212053
30Tubular atrophy (HP:0000092)2.75621292
31Supranuclear gaze palsy (HP:0000605)2.74627294
32Attenuation of retinal blood vessels (HP:0007843)2.72024703
33Retinal dysplasia (HP:0007973)2.69024168
34Sclerocornea (HP:0000647)2.68922703
35Polydipsia (HP:0001959)2.68221719
36Abnormal drinking behavior (HP:0030082)2.68221719
37Onion bulb formation (HP:0003383)2.64791302
38Nephronophthisis (HP:0000090)2.59387353
39Abnormal rod and cone electroretinograms (HP:0008323)2.56174391
40Gait imbalance (HP:0002141)2.55918007
41True hermaphroditism (HP:0010459)2.46282500
42Congenital primary aphakia (HP:0007707)2.46038798
43Parakeratosis (HP:0001036)2.44425696
44Submucous cleft hard palate (HP:0000176)2.43473101
45Lissencephaly (HP:0001339)2.40859224
46Decreased central vision (HP:0007663)2.39811805
47Cerebral inclusion bodies (HP:0100314)2.38564197
48Nephrogenic diabetes insipidus (HP:0009806)2.37997986
49Gaze-evoked nystagmus (HP:0000640)2.31795099
50Abnormal biliary tract physiology (HP:0012439)2.26461121
51Bile duct proliferation (HP:0001408)2.26461121
52Sensory axonal neuropathy (HP:0003390)2.26423628
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.26354803
54Furrowed tongue (HP:0000221)2.26227117
55Pendular nystagmus (HP:0012043)2.25793747
56Hypoplasia of the pons (HP:0012110)2.24033391
57Broad-based gait (HP:0002136)2.23886119
58Renal cortical cysts (HP:0000803)2.23884879
59Abnormality of the pons (HP:0007361)2.23774191
60Partial duplication of thumb phalanx (HP:0009944)2.21947021
61Nasal polyposis (HP:0100582)2.21359792
62Progressive cerebellar ataxia (HP:0002073)2.20180901
63Peripheral hypomyelination (HP:0007182)2.20179391
64Decreased electroretinogram (ERG) amplitude (HP:0000654)2.17676186
65Progressive inability to walk (HP:0002505)2.16186916
66Chin dimple (HP:0010751)2.15365949
67Pancreatic fibrosis (HP:0100732)2.14707569
68Keratoconus (HP:0000563)2.14664106
69Increased corneal curvature (HP:0100692)2.14664106
70Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.13863105
71Polyuria (HP:0000103)2.11747873
72Large for gestational age (HP:0001520)2.10928430
73Esophageal atresia (HP:0002032)2.10117767
74Myokymia (HP:0002411)2.09581000
75Abnormal auditory evoked potentials (HP:0006958)2.08673068
76Congenital, generalized hypertrichosis (HP:0004540)2.06195368
77Stridor (HP:0010307)2.05040872
78Genital tract atresia (HP:0001827)2.04334327
79Tubulointerstitial nephritis (HP:0001970)2.03979288
80Infertility (HP:0000789)2.03598966
81Intention tremor (HP:0002080)2.03541872
82Genetic anticipation (HP:0003743)2.03537352
83Hypokalemic alkalosis (HP:0001949)2.02683729
84Inability to walk (HP:0002540)2.02366183
85Cutaneous finger syndactyly (HP:0010554)2.01691444
86Abnormal connection of the cardiac segments (HP:0011545)2.00437112
87Abnormal ventriculo-arterial connection (HP:0011563)2.00437112
88Transposition of the great arteries (HP:0001669)2.00437112
89Bony spicule pigmentary retinopathy (HP:0007737)2.00291494
90Arterial tortuosity (HP:0005116)2.00172464
91Methylmalonic acidemia (HP:0002912)2.00160032
92Decreased circulating renin level (HP:0003351)1.99992849
93Short nail (HP:0001799)1.97353518
94Down-sloping shoulders (HP:0200021)1.96832246
95Abnormal tarsal ossification (HP:0008369)1.95838499
96Vaginal atresia (HP:0000148)1.95591468
97Postaxial hand polydactyly (HP:0001162)1.95018366
98Absent speech (HP:0001344)1.93283511
99Optic nerve hypoplasia (HP:0000609)1.91198463
100Abnormality of macular pigmentation (HP:0008002)1.90828247
101Febrile seizures (HP:0002373)1.90803618
102Hemiparesis (HP:0001269)1.89798373
103Hypoplasia of the ulna (HP:0003022)1.89662916
104Partial duplication of the phalanx of hand (HP:0009999)1.89553662
105Aplasia/Hypoplasia of the tibia (HP:0005772)1.88979036
106Bronchitis (HP:0012387)1.88744751
107Dysmetria (HP:0001310)1.88025292
108Abnormality of midbrain morphology (HP:0002418)1.86752911
109Molar tooth sign on MRI (HP:0002419)1.86752911
110Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86574448
111Aplasia/Hypoplasia of the fovea (HP:0008060)1.86048850
112Hypoplasia of the fovea (HP:0007750)1.86048850
113Focal motor seizures (HP:0011153)1.85976163
114Acute necrotizing encephalopathy (HP:0006965)1.85699339
115Abnormality of the labia minora (HP:0012880)1.85248039
116Aplasia/Hypoplasia of the fibula (HP:0006492)1.83600700
117Double outlet right ventricle (HP:0001719)1.83445178
118Congenital malformation of the right heart (HP:0011723)1.83445178
119Abnormality of the renal medulla (HP:0100957)1.83030281
120Protruding tongue (HP:0010808)1.82933689
121Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82798134
122Abnormality of alanine metabolism (HP:0010916)1.82798134
123Hyperalaninemia (HP:0003348)1.82798134
124Mitochondrial inheritance (HP:0001427)1.82149294
125Segmental peripheral demyelination/remyelination (HP:0003481)1.82075744
126Male pseudohermaphroditism (HP:0000037)1.80767434
127Methylmalonic aciduria (HP:0012120)1.80198853
128Decreased motor nerve conduction velocity (HP:0003431)1.79106338
129Supernumerary spleens (HP:0009799)1.76918106
130Stomach cancer (HP:0012126)1.76635931
131Abnormality of the fovea (HP:0000493)1.76408084
132Hypothermia (HP:0002045)1.76136816
133Adrenal hypoplasia (HP:0000835)1.75994566
134Occipital encephalocele (HP:0002085)1.75723895
135Severe muscular hypotonia (HP:0006829)1.75058552
136Lipid accumulation in hepatocytes (HP:0006561)1.74791426
137Poor coordination (HP:0002370)1.74204248
138Hydroxyprolinuria (HP:0003080)1.73804178
139Abnormality of proline metabolism (HP:0010907)1.73804178
140Increased CSF lactate (HP:0002490)1.73768791
141Pachygyria (HP:0001302)1.73416428
142Fibular hypoplasia (HP:0003038)1.72377010
1433-Methylglutaconic aciduria (HP:0003535)1.71940733
144Cupped ear (HP:0000378)1.71607284
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.71378468
146Anencephaly (HP:0002323)1.71122964
147Preaxial hand polydactyly (HP:0001177)1.70917252
148Vascular tortuosity (HP:0004948)1.70242221
149Chorioretinal atrophy (HP:0000533)1.70173897
150Abnormality of the nasal mucosa (HP:0000433)1.69363156
151Broad metatarsal (HP:0001783)1.68993682
152Abnormality of the fibula (HP:0002991)1.68164392
153Fibular aplasia (HP:0002990)1.66685805
154Leukodystrophy (HP:0002415)1.64257539
155Confusion (HP:0001289)1.64192665
156Spastic gait (HP:0002064)1.64049145
157Hyporeflexia of lower limbs (HP:0002600)1.62056498
158Steatorrhea (HP:0002570)1.61634735
159Foot dorsiflexor weakness (HP:0009027)1.60980677
160Cutaneous syndactyly (HP:0012725)1.60320246
161Postaxial foot polydactyly (HP:0001830)1.59308086
162Bifid scrotum (HP:0000048)1.59121572
163Microglossia (HP:0000171)1.58787393
164Aplasia/Hypoplasia of the ulna (HP:0006495)1.58052961
165Hypoplasia of the uterus (HP:0000013)1.55817431
166Flat acetabular roof (HP:0003180)1.54986633
167Abnormality of the umbilical cord (HP:0010881)1.54687698
168Centrally nucleated skeletal muscle fibers (HP:0003687)1.53735206
169Absent septum pellucidum (HP:0001331)1.53539290
170Metabolic alkalosis (HP:0200114)1.53323155
171Abnormality of the phalanges of the 2nd finger (HP:0009541)1.52643911
172Insidious onset (HP:0003587)1.50717176
173Termporal pattern (HP:0011008)1.50717176
174Natal tooth (HP:0000695)1.49299586
175Prominent occiput (HP:0000269)1.48845762
176Congenital hepatic fibrosis (HP:0002612)1.48667509
177Abnormality of dentin (HP:0010299)1.48099207

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.91319336
2FRK5.87331349
3BMPR1B4.37816385
4TAOK33.42298720
5WNK43.27392824
6ADRBK23.08461454
7TGFBR12.92233051
8PNCK2.74148154
9OXSR12.67955035
10MAPK152.55301169
11WNK32.55287877
12ERBB32.52339532
13GRK12.50045607
14MAP4K22.41166846
15INSRR2.37893808
16EPHB12.31141654
17TNIK2.27519174
18PINK12.25340428
19TLK12.18512448
20MAPKAPK52.12843438
21BMPR22.02595832
22CDK82.02421127
23NUAK11.97360102
24ACVR1B1.95889517
25PKN11.85356473
26TXK1.84704000
27LIMK11.82942202
28BCR1.77877004
29WNK11.57569108
30TESK11.56136933
31MET1.53957544
32NEK61.51277466
33MAP3K41.49704539
34PRPF4B1.44375061
35UHMK11.36457344
36BRSK21.35034238
37ROCK21.32244248
38PAK61.30709981
39MAP2K21.30458840
40PTK2B1.24534472
41ADRBK11.17345434
42NME11.14189258
43MARK11.12954616
44CAMK2B1.12914796
45LMTK21.12368360
46MUSK1.11045604
47CASK1.06391638
48VRK11.04529909
49SGK4941.04412401
50SGK2231.04412401
51NTRK21.03986661
52MKNK20.98031315
53MST40.97680601
54CAMK2A0.95269424
55NTRK10.94807272
56PIM20.93092726
57CAMK2D0.93029335
58PBK0.91144335
59MAP2K70.89065663
60CDK190.88733684
61TRIM280.87537552
62CDK90.87268497
63FGR0.85132921
64PDK30.82926346
65PDK40.82926346
66TIE10.82697697
67IRAK10.82680468
68CSNK1G20.82383167
69ITK0.81352606
70CAMK2G0.81150103
71NTRK30.80812540
72MAPKAPK30.80728060
73EPHA40.80287938
74PAK30.79544400
75WEE10.79462439
76EPHA30.77675239
77PDK20.76483455
78FGFR20.75770311
79PHKG10.74977571
80PHKG20.74977571
81TEC0.73724390
82KIT0.72155930
83PLK40.71919139
84DYRK20.71581264
85PRKCE0.71423834
86DYRK1B0.70220907
87GRK70.69848683
88STK38L0.69332399
89MARK30.67629059
90CAMKK20.65861998
91MAPK100.64881308
92PIK3CA0.61903467
93CDK140.61798542
94ERBB40.61451129
95CDK50.59702440
96PRKCH0.58555124
97CSNK1A1L0.57610027
98CSNK1G30.57584335
99NLK0.56249109
100CLK10.55856076
101CSNK1G10.55690175
102BCKDK0.54719417
103PRKCQ0.53569001
104PAK20.52701347
105DAPK20.52670634
106TYRO30.51874879
107NEK90.51662838
108IKBKB0.51232088
109PRKD10.50910404
110DAPK30.49725816
111PRKCI0.48003674
112CDK30.47192359
113CDK150.46955354
114VRK20.46915293
115MKNK10.46806375
116PLK20.45453325
117PLK30.44878254
118RPS6KA50.44534293
119MAP2K60.44469952
120STK110.43648978
121HIPK20.43249176
122CDK180.43225405
123MAPK130.42607146
124CAMK10.41528114
125DYRK1A0.39944081
126GRK50.38717907
127PRKG10.38575004
128MINK10.36999201
129CSNK1A10.36198569
130MST1R0.35961686
131PRKCA0.35321305
132CDK11A0.35133980
133FLT30.34672121
134PASK0.34258309
135FYN0.34230275
136OBSCN0.33820434
137CSNK1D0.33008046
138CHUK0.32828717
139PRKCZ0.32405726
140TRPM70.32235151
141ZAK0.32058459
142MAPK40.31998489
143PRKAA20.31056680
144PRKACA0.30952727
145DYRK30.29893560
146STK30.29810920
147PRKAA10.29784253
148PRKACB0.29305685
149PTK60.29207244
150ROCK10.28306642
151FER0.27857937
152RPS6KA20.26931051
153PRKCG0.26917363

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000534.69304979
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.47917501
3Pentose and glucuronate interconversions_Homo sapiens_hsa000403.39573686
4Steroid biosynthesis_Homo sapiens_hsa001003.38979930
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.98566672
6Fatty acid elongation_Homo sapiens_hsa000622.79514846
7Steroid hormone biosynthesis_Homo sapiens_hsa001402.75046246
8Chemical carcinogenesis_Homo sapiens_hsa052042.54794846
9Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.47543603
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.35554978
11Nitrogen metabolism_Homo sapiens_hsa009102.35034750
12Retinol metabolism_Homo sapiens_hsa008302.31718670
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.30903055
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22504673
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.20065186
16Selenocompound metabolism_Homo sapiens_hsa004502.06323626
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.06271807
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.95600208
19Ether lipid metabolism_Homo sapiens_hsa005651.91265030
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.89958409
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.89286351
22Sulfur metabolism_Homo sapiens_hsa009201.87900941
23Homologous recombination_Homo sapiens_hsa034401.86000494
24RNA polymerase_Homo sapiens_hsa030201.72961421
25Tryptophan metabolism_Homo sapiens_hsa003801.70230451
26Starch and sucrose metabolism_Homo sapiens_hsa005001.66834964
27Protein export_Homo sapiens_hsa030601.62477461
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57155102
29Oxidative phosphorylation_Homo sapiens_hsa001901.54528176
30Axon guidance_Homo sapiens_hsa043601.52327929
31Caffeine metabolism_Homo sapiens_hsa002321.52252670
32Fanconi anemia pathway_Homo sapiens_hsa034601.51738015
33ABC transporters_Homo sapiens_hsa020101.39978528
34Glutathione metabolism_Homo sapiens_hsa004801.39534010
35Basal transcription factors_Homo sapiens_hsa030221.33684757
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.30243300
37Arginine and proline metabolism_Homo sapiens_hsa003301.29676151
38Linoleic acid metabolism_Homo sapiens_hsa005911.27487667
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24062120
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21255657
41Butanoate metabolism_Homo sapiens_hsa006501.16135438
42Peroxisome_Homo sapiens_hsa041461.12984121
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.12332047
44Histidine metabolism_Homo sapiens_hsa003401.11609281
45Regulation of autophagy_Homo sapiens_hsa041401.11238004
46Nicotine addiction_Homo sapiens_hsa050331.08047715
47Huntingtons disease_Homo sapiens_hsa050161.07943587
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05926461
49Alzheimers disease_Homo sapiens_hsa050101.04346776
50Glutamatergic synapse_Homo sapiens_hsa047241.02944987
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00395601
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99566742
53Dorso-ventral axis formation_Homo sapiens_hsa043200.99258797
54Propanoate metabolism_Homo sapiens_hsa006400.98844828
55Gap junction_Homo sapiens_hsa045400.97370792
56Amphetamine addiction_Homo sapiens_hsa050310.97067506
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.96759675
58beta-Alanine metabolism_Homo sapiens_hsa004100.94503691
59Circadian entrainment_Homo sapiens_hsa047130.94451129
60GABAergic synapse_Homo sapiens_hsa047270.93141935
61RNA degradation_Homo sapiens_hsa030180.93140328
62Renin secretion_Homo sapiens_hsa049240.90657212
63Vitamin B6 metabolism_Homo sapiens_hsa007500.89211056
64Morphine addiction_Homo sapiens_hsa050320.89146432
65Parkinsons disease_Homo sapiens_hsa050120.88325755
66Asthma_Homo sapiens_hsa053100.85018872
67Phagosome_Homo sapiens_hsa041450.84664030
68Cardiac muscle contraction_Homo sapiens_hsa042600.83533192
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83081049
70One carbon pool by folate_Homo sapiens_hsa006700.82829585
71Vibrio cholerae infection_Homo sapiens_hsa051100.82823887
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82698793
73Serotonergic synapse_Homo sapiens_hsa047260.82654793
74Collecting duct acid secretion_Homo sapiens_hsa049660.81977976
75Sphingolipid metabolism_Homo sapiens_hsa006000.77646717
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77367568
77Salivary secretion_Homo sapiens_hsa049700.76393803
78Phenylalanine metabolism_Homo sapiens_hsa003600.74080613
79Purine metabolism_Homo sapiens_hsa002300.73079075
80Arachidonic acid metabolism_Homo sapiens_hsa005900.72563337
81Type I diabetes mellitus_Homo sapiens_hsa049400.71265121
82Cocaine addiction_Homo sapiens_hsa050300.70573458
83Synaptic vesicle cycle_Homo sapiens_hsa047210.69551705
84Olfactory transduction_Homo sapiens_hsa047400.64786265
85Glycerolipid metabolism_Homo sapiens_hsa005610.64496295
86Gastric acid secretion_Homo sapiens_hsa049710.64233135
87Primary immunodeficiency_Homo sapiens_hsa053400.63595550
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61890805
89Pyruvate metabolism_Homo sapiens_hsa006200.61872202
90Metabolic pathways_Homo sapiens_hsa011000.61121523
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60681778
92Taste transduction_Homo sapiens_hsa047420.60548303
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60004520
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59456151
95Rheumatoid arthritis_Homo sapiens_hsa053230.59111662
96Dopaminergic synapse_Homo sapiens_hsa047280.58908889
97Fatty acid degradation_Homo sapiens_hsa000710.58845265
98Graft-versus-host disease_Homo sapiens_hsa053320.58224668
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55738654
100Dilated cardiomyopathy_Homo sapiens_hsa054140.55436082
101Fatty acid biosynthesis_Homo sapiens_hsa000610.54972324
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54628069
103Fatty acid metabolism_Homo sapiens_hsa012120.54482123
104Sulfur relay system_Homo sapiens_hsa041220.54005669
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50470507
106Pyrimidine metabolism_Homo sapiens_hsa002400.49872196
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49163030
108Hedgehog signaling pathway_Homo sapiens_hsa043400.48783144
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.48686884
110Autoimmune thyroid disease_Homo sapiens_hsa053200.48681069
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48074125
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47387210
113Calcium signaling pathway_Homo sapiens_hsa040200.46892713
114Long-term potentiation_Homo sapiens_hsa047200.45792969
115Allograft rejection_Homo sapiens_hsa053300.45583995
116Tight junction_Homo sapiens_hsa045300.44342501
117Fat digestion and absorption_Homo sapiens_hsa049750.44304948
118Ovarian steroidogenesis_Homo sapiens_hsa049130.43361689
119Circadian rhythm_Homo sapiens_hsa047100.43220176
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42825586
121Tyrosine metabolism_Homo sapiens_hsa003500.41470666
122Proteasome_Homo sapiens_hsa030500.40762030
123Oxytocin signaling pathway_Homo sapiens_hsa049210.40710613
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40579473
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40220218
126Cholinergic synapse_Homo sapiens_hsa047250.39808729
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.38884808
128ECM-receptor interaction_Homo sapiens_hsa045120.38274207
129Ribosome_Homo sapiens_hsa030100.37675772
130Non-homologous end-joining_Homo sapiens_hsa034500.36424963
131Long-term depression_Homo sapiens_hsa047300.35983966
132Mineral absorption_Homo sapiens_hsa049780.35361850
133Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35000588
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33109832
135Renal cell carcinoma_Homo sapiens_hsa052110.33071087
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.32985649
137cAMP signaling pathway_Homo sapiens_hsa040240.31218017
138MAPK signaling pathway_Homo sapiens_hsa040100.31051626
139Melanogenesis_Homo sapiens_hsa049160.30118300
140Hippo signaling pathway_Homo sapiens_hsa043900.28944548
141Basal cell carcinoma_Homo sapiens_hsa052170.28654529
142Insulin secretion_Homo sapiens_hsa049110.24694611
143Phototransduction_Homo sapiens_hsa047440.23993533
144Ras signaling pathway_Homo sapiens_hsa040140.23922944

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