KIF7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)6.95352141
2polyketide metabolic process (GO:0030638)6.95352141
3doxorubicin metabolic process (GO:0044598)6.95352141
4protein localization to kinetochore (GO:0034501)6.09546045
5regulation of telomere maintenance via telomerase (GO:0032210)5.24961713
6heterochromatin organization (GO:0070828)5.09714401
7regulation of response to osmotic stress (GO:0047484)5.08712067
8negative regulation of epidermis development (GO:0045683)5.05962561
9regulation of mammary gland epithelial cell proliferation (GO:0033599)4.96681579
10mitotic sister chromatid segregation (GO:0000070)4.93038110
11nuclear pore complex assembly (GO:0051292)4.93035017
12negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.91679616
13somite rostral/caudal axis specification (GO:0032525)4.91042037
14notochord development (GO:0030903)4.75645097
15protein localization to chromosome, centromeric region (GO:0071459)4.73436343
16negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.69979041
17nuclear pore organization (GO:0006999)4.59160629
18DNA replication-dependent nucleosome organization (GO:0034723)4.54972372
19DNA replication-dependent nucleosome assembly (GO:0006335)4.54972372
20maintenance of protein location in nucleus (GO:0051457)4.48607381
21sister chromatid segregation (GO:0000819)4.47802333
22histone H4-K12 acetylation (GO:0043983)4.46305420
23histone H4-K8 acetylation (GO:0043982)4.45997622
24histone H4-K5 acetylation (GO:0043981)4.45997622
25negative regulation of cell cycle G2/M phase transition (GO:1902750)4.44530319
26regulation of nuclear cell cycle DNA replication (GO:0033262)4.39626887
27chromatin assembly (GO:0031497)4.39307878
28aminoglycoside antibiotic metabolic process (GO:0030647)4.28224409
29negative regulation of telomerase activity (GO:0051974)4.27589151
30pre-miRNA processing (GO:0031054)4.22352355
31regulation of gene silencing by RNA (GO:0060966)4.12859125
32regulation of posttranscriptional gene silencing (GO:0060147)4.12859125
33regulation of gene silencing by miRNA (GO:0060964)4.12859125
34muscle organ morphogenesis (GO:0048644)4.10075560
35rRNA transcription (GO:0009303)4.03940969
36regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.93075920
37positive regulation of DNA-dependent DNA replication (GO:2000105)3.91268664
38bone trabecula formation (GO:0060346)3.85949667
39DNA unwinding involved in DNA replication (GO:0006268)3.74116935
40negative regulation of epidermal cell differentiation (GO:0045605)3.71471562
41pore complex assembly (GO:0046931)3.69678270
42RNA stabilization (GO:0043489)3.64797075
43mRNA stabilization (GO:0048255)3.64797075
44convergent extension (GO:0060026)3.64270967
45DNA replication checkpoint (GO:0000076)3.59908644
46regulation of MHC class I biosynthetic process (GO:0045343)3.56494270
47outer ear morphogenesis (GO:0042473)3.56156804
48paraxial mesoderm development (GO:0048339)3.53921461
49DNA duplex unwinding (GO:0032508)3.49627288
50primitive streak formation (GO:0090009)3.46650356
51DNA geometric change (GO:0032392)3.46439537
52branching involved in mammary gland duct morphogenesis (GO:0060444)3.43895227
53mitotic chromosome condensation (GO:0007076)3.42912025
54histone H4-K16 acetylation (GO:0043984)3.39055187
55protein heterotrimerization (GO:0070208)3.36270276
56regulation of cilium movement (GO:0003352)3.36191434
57regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.31539272
58regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.27707398
59regulation of hippo signaling (GO:0035330)3.20376656
60ribosomal small subunit biogenesis (GO:0042274)3.20350946
61trophectodermal cell differentiation (GO:0001829)3.17315863
62cochlea morphogenesis (GO:0090103)3.14346023
63regulation of apoptotic process involved in morphogenesis (GO:1902337)3.12040109
64negative regulation of telomere maintenance (GO:0032205)3.09769255
65collagen fibril organization (GO:0030199)3.08549178
66regulation of telomere maintenance (GO:0032204)3.07048773
67regulation of double-strand break repair (GO:2000779)3.05934210
68Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.03190327
69intracellular estrogen receptor signaling pathway (GO:0030520)3.00664402
70maternal placenta development (GO:0001893)3.00407906
71maturation of SSU-rRNA (GO:0030490)2.99563454
72rRNA methylation (GO:0031167)2.98294147
73negative regulation of gene silencing (GO:0060969)2.97844670
74cell fate commitment involved in formation of primary germ layer (GO:0060795)2.97498506
75hormone catabolic process (GO:0042447)2.95928548
76chromosome condensation (GO:0030261)2.95003253
77G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.94623416
78regulation of gene silencing (GO:0060968)2.92728461
79positive regulation of protein deacetylation (GO:0090312)2.92543104
80anterior/posterior axis specification (GO:0009948)2.90453999
81regulation of translational fidelity (GO:0006450)2.89593879
82cell migration involved in gastrulation (GO:0042074)2.88538911
83protein localization to chromosome (GO:0034502)2.86197049
84regulation of establishment of planar polarity (GO:0090175)2.84993499
85intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.84537807
86NLS-bearing protein import into nucleus (GO:0006607)2.84430795
87ribosome biogenesis (GO:0042254)2.83223910
88polarized epithelial cell differentiation (GO:0030859)2.83080365
89spindle assembly (GO:0051225)2.83023433
90DNA conformation change (GO:0071103)2.82893847
91adherens junction assembly (GO:0034333)2.81832920
92regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.80908570
93kidney mesenchyme development (GO:0072074)2.79782534
94planar cell polarity pathway involved in neural tube closure (GO:0090179)2.79467946
95mitotic nuclear envelope disassembly (GO:0007077)2.78854708
96DNA replication initiation (GO:0006270)2.78600272
97interferon-gamma production (GO:0032609)2.77202955
98basement membrane organization (GO:0071711)2.75769168
99formation of translation preinitiation complex (GO:0001731)2.74231858
100protein retention in ER lumen (GO:0006621)2.74037319
101cytidine deamination (GO:0009972)2.73886031
102cytidine metabolic process (GO:0046087)2.73886031
103cytidine catabolic process (GO:0006216)2.73886031
104hippo signaling (GO:0035329)2.73558829
105negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.73128146
106positive regulation of histone deacetylation (GO:0031065)2.72916793
107rRNA modification (GO:0000154)2.72905744
108atrial septum morphogenesis (GO:0060413)2.72703031
109tooth mineralization (GO:0034505)2.72103926
110chondrocyte proliferation (GO:0035988)2.71971073
111establishment of apical/basal cell polarity (GO:0035089)2.71191300
112protein complex localization (GO:0031503)2.71043650
113mesenchymal-epithelial cell signaling (GO:0060638)2.70626231
114regulation of G0 to G1 transition (GO:0070316)2.70251932
115DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.70005983
116microtubule severing (GO:0051013)2.69451459
117retinoic acid receptor signaling pathway (GO:0048384)2.69426918
118vitamin A metabolic process (GO:0006776)2.68626442
119regulation of telomerase activity (GO:0051972)2.68446307
120DNA damage response, detection of DNA damage (GO:0042769)2.68429047
121phenol-containing compound catabolic process (GO:0019336)2.67275268
122embryonic axis specification (GO:0000578)2.66157449
123endothelial cell morphogenesis (GO:0001886)2.64347871
124endodermal cell differentiation (GO:0035987)2.63684227
125axon extension involved in axon guidance (GO:0048846)2.61621421
126neuron projection extension involved in neuron projection guidance (GO:1902284)2.61621421
127maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.60941415
128cardiovascular system development (GO:0072358)2.60208751
129regulation of translation in response to stress (GO:0043555)2.59945888
130cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.58348237
131embryonic skeletal joint morphogenesis (GO:0060272)2.57171651
132cranial nerve morphogenesis (GO:0021602)2.53280989
133neural tube development (GO:0021915)2.51059419
134non-canonical Wnt signaling pathway (GO:0035567)2.50744074
135cell-substrate adherens junction assembly (GO:0007045)2.49981008
136focal adhesion assembly (GO:0048041)2.49981008
137cell migration involved in heart development (GO:0060973)2.48884562
138cell migration involved in sprouting angiogenesis (GO:0002042)2.47329174
139negative regulation of chondrocyte differentiation (GO:0032331)2.45300127
140L-serine metabolic process (GO:0006563)2.39603474
141establishment or maintenance of monopolar cell polarity (GO:0061339)2.38183948
142establishment of monopolar cell polarity (GO:0061162)2.38183948
143lung-associated mesenchyme development (GO:0060484)2.37726902
144DNA strand elongation involved in DNA replication (GO:0006271)2.35684718
145camera-type eye morphogenesis (GO:0048593)2.35468944
146DNA strand elongation (GO:0022616)2.34651394
147skin morphogenesis (GO:0043589)2.34127579
148cell-substrate junction assembly (GO:0007044)2.34001727
149regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.33585811
150cellular protein complex localization (GO:0034629)2.32440057
151negative regulation of catenin import into nucleus (GO:0035414)2.29411009
152muscle cell migration (GO:0014812)2.29408708
153nucleosome disassembly (GO:0006337)2.28319081
154protein-DNA complex disassembly (GO:0032986)2.28319081
155regulation of heart morphogenesis (GO:2000826)2.26452418
156eye morphogenesis (GO:0048592)2.25443768
157proximal/distal pattern formation (GO:0009954)2.25430939
158atrioventricular valve morphogenesis (GO:0003181)2.25133327
159spliceosomal tri-snRNP complex assembly (GO:0000244)2.22398321
160establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.22068956
161semaphorin-plexin signaling pathway (GO:0071526)2.21540967
162positive regulation of cartilage development (GO:0061036)2.20879819
163negative regulation of mRNA processing (GO:0050686)2.20132445
164peptidyl-arginine omega-N-methylation (GO:0035247)2.18617684
165meiotic chromosome segregation (GO:0045132)2.17281174
166DNA strand renaturation (GO:0000733)2.16747216
167organ induction (GO:0001759)2.16332785
168positive regulation of SMAD protein import into nucleus (GO:0060391)2.15596462
169lymph vessel development (GO:0001945)2.14319155
170embryonic skeletal system morphogenesis (GO:0048704)2.12528859
171mitotic sister chromatid cohesion (GO:0007064)2.12454148
172histone arginine methylation (GO:0034969)2.12378159
173regulation of RNA export from nucleus (GO:0046831)2.12240022
174heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.11734324
175axon extension (GO:0048675)2.11576557
176regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.11505122
177metanephric mesenchyme development (GO:0072075)2.11145488
178mitotic metaphase plate congression (GO:0007080)2.10530293
179ventricular cardiac muscle cell development (GO:0055015)2.09909212
180proline biosynthetic process (GO:0006561)2.08956671

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.91245536
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.28622462
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.28622462
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.28622462
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.95348111
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.64401266
7TP63_19390658_ChIP-ChIP_HaCaT_Human3.31817429
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.19038870
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.89166038
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.69480465
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.66432224
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.65123330
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.63844466
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.60111239
15SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.51823244
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.49940792
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.44600062
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.39941228
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.38611180
20TCF3_18692474_ChIP-Seq_MEFs_Mouse2.36328175
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.34882955
22TCF3_18692474_ChIP-Seq_MESCs_Mouse2.31897136
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.29447199
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.04592022
25MYC_19079543_ChIP-ChIP_MESCs_Mouse1.98646812
26HIF1A_21447827_ChIP-Seq_MCF-7_Human1.88480157
27NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.88296970
28ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.85117996
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.84347232
30KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.82685039
31MYC_22102868_ChIP-Seq_BL_Human1.78710088
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78622206
33STAT3_1855785_ChIP-Seq_MESCs_Mouse1.78150083
34POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.75890899
35SOX2_18555785_ChIP-Seq_MESCs_Mouse1.74922267
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72922126
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.71823834
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67527548
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.67311204
40SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.67302113
41NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.67294096
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.66705200
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.63376298
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.62447665
45LXR_22292898_ChIP-Seq_THP-1_Human1.59556711
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.59394128
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58925526
48POU5F1_16518401_ChIP-PET_MESCs_Mouse1.58257433
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.56577435
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54837317
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.53478202
52TTF2_22483619_ChIP-Seq_HELA_Human1.51432295
53TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.51323330
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49552801
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47611628
56UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40544522
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39886582
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.38793502
59MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38128411
60CLOCK_20551151_ChIP-Seq_293T_Human1.36850095
61TET1_21451524_ChIP-Seq_MESCs_Mouse1.36258616
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35793023
63ZNF263_19887448_ChIP-Seq_K562_Human1.35657164
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.34689659
65* KDM2B_26808549_Chip-Seq_K562_Human1.34657059
66CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.32090186
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.32022420
68NANOG_21062744_ChIP-ChIP_HESCs_Human1.29245107
69CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29185357
70JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.28504465
71NANOG_18692474_ChIP-Seq_MESCs_Mouse1.28160772
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27292391
73AR_21909140_ChIP-Seq_LNCAP_Human1.27079139
74SOX2_18692474_ChIP-Seq_MESCs_Mouse1.26960899
75NANOG_18692474_ChIP-Seq_MEFs_Mouse1.26391208
76POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.26282561
77PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.24352551
78EED_16625203_ChIP-ChIP_MESCs_Mouse1.23393630
79TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20064752
80NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.19952468
81NANOG_16153702_ChIP-ChIP_HESCs_Human1.18589819
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17731848
83GABP_19822575_ChIP-Seq_HepG2_Human1.16954471
84DCP1A_22483619_ChIP-Seq_HELA_Human1.16628685
85VDR_21846776_ChIP-Seq_THP-1_Human1.16119553
86OCT4_18692474_ChIP-Seq_MEFs_Mouse1.15786890
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14884161
88TP53_22127205_ChIP-Seq_IMR90_Human1.14749438
89* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14570340
90SOX2_18692474_ChIP-Seq_MEFs_Mouse1.12946667
91UBF1/2_26484160_Chip-Seq_HMECs_Human1.12264930
92TCF7_22412390_ChIP-Seq_EML_Mouse1.11859574
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10170737
94YY1_21170310_ChIP-Seq_MESCs_Mouse1.09269047
95EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07949931
96RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06906772
97EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06906772
98DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05461164
99XRN2_22483619_ChIP-Seq_HELA_Human1.05065075
100SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05056022
101TP63_17297297_ChIP-ChIP_HaCaT_Human1.04754399
102NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03935463
103ATF3_27146783_Chip-Seq_COLON_Human1.03715082
104ELK3_25401928_ChIP-Seq_HUVEC_Human1.03711465
105POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.03622252
106POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03223647
107TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.02461603
108E2F1_17053090_ChIP-ChIP_MCF-7_Human1.02311188
109KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01738604
110NCOR1_26117541_ChIP-Seq_K562_Human1.01664270
111E2F1_21310950_ChIP-Seq_MCF-7_Human0.99972226
112EZH2_27304074_Chip-Seq_ESCs_Mouse0.99781113
113PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.99570575
114CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98911052
115HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98639258
116FOXP1_21924763_ChIP-Seq_HESCs_Human0.98604017
117MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98202464
118YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98122304
119* P68_20966046_ChIP-Seq_HELA_Human0.97983314
120MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.97796005
121KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97749567
122NANOG_16518401_ChIP-PET_MESCs_Mouse0.97722345
123ETS1_20019798_ChIP-Seq_JURKAT_Human0.97322712
124WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97144670
125THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96544093
126CREB1_15753290_ChIP-ChIP_HEK293T_Human0.96344566
127IRF1_19129219_ChIP-ChIP_H3396_Human0.95854903
128RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95838762
129RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95506321
130OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95443615
131SOX2_16153702_ChIP-ChIP_HESCs_Human0.93918644
132SALL1_21062744_ChIP-ChIP_HESCs_Human0.92581650
133ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91466444
134EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90989822
135KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90857279
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90401069
137CIITA_25753668_ChIP-Seq_RAJI_Human0.88362234
138NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86783614
139KDM5A_27292631_Chip-Seq_BREAST_Human0.84518621
140CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84362431
141TBX3_20139965_ChIP-Seq_ESCs_Mouse0.81773716
142NOTCH1_21737748_ChIP-Seq_TLL_Human0.81208461
143ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81144675
144E2F1_18555785_ChIP-Seq_MESCs_Mouse0.80676602
145TBX3_20139965_ChIP-Seq_MESCs_Mouse0.79997558
146ZFX_18555785_ChIP-Seq_MESCs_Mouse0.79794086
147* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79093733
148RACK7_27058665_Chip-Seq_MCF-7_Human0.78926035
149DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.77496736

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.30980269
2MP0010030_abnormal_orbit_morphology2.97651136
3MP0006292_abnormal_olfactory_placode2.95350379
4MP0005503_abnormal_tendon_morphology2.87876450
5MP0003890_abnormal_embryonic-extraembry2.82021375
6MP0003122_maternal_imprinting2.78172983
7MP0004264_abnormal_extraembryonic_tissu2.69586718
8MP0010352_gastrointestinal_tract_polyps2.58428191
9MP0008057_abnormal_DNA_replication2.57989237
10MP0004957_abnormal_blastocyst_morpholog2.55885388
11MP0003121_genomic_imprinting2.45561895
12MP0003011_delayed_dark_adaptation2.39619542
13MP0005394_taste/olfaction_phenotype2.35602242
14MP0005499_abnormal_olfactory_system2.35602242
15MP0002254_reproductive_system_inflammat2.33544138
16MP0002653_abnormal_ependyma_morphology2.33229086
17MP0005257_abnormal_intraocular_pressure2.32404588
18MP0004858_abnormal_nervous_system2.24217380
19MP0003123_paternal_imprinting2.12829183
20MP0001293_anophthalmia1.97913002
21MP0001672_abnormal_embryogenesis/_devel1.93547157
22MP0005380_embryogenesis_phenotype1.93547157
23MP0009384_cardiac_valve_regurgitation1.90201521
24MP0003111_abnormal_nucleus_morphology1.88673627
25MP0003279_aneurysm1.87919323
26MP0003077_abnormal_cell_cycle1.84778694
27MP0000751_myopathy1.84236714
28MP0002932_abnormal_joint_morphology1.82307841
29MP0000049_abnormal_middle_ear1.79955596
30MP0002088_abnormal_embryonic_growth/wei1.79691590
31MP0000678_abnormal_parathyroid_gland1.79566295
32MP0003984_embryonic_growth_retardation1.77950432
33MP0010368_abnormal_lymphatic_system1.72323569
34MP0001958_emphysema1.72229689
35MP0010094_abnormal_chromosome_stability1.71553967
36MP0005623_abnormal_meninges_morphology1.68258800
37MP0001849_ear_inflammation1.66666145
38MP0005275_abnormal_skin_tensile1.66328874
39MP0001299_abnormal_eye_distance/1.62625269
40* MP0002085_abnormal_embryonic_tissue1.61425054
41MP0000350_abnormal_cell_proliferation1.61287180
42MP0005075_abnormal_melanosome_morpholog1.59717293
43MP0003938_abnormal_ear_development1.59273287
44MP0002092_abnormal_eye_morphology1.59057567
45MP0000428_abnormal_craniofacial_morphol1.56722672
46MP0004197_abnormal_fetal_growth/weight/1.56114366
47MP0002084_abnormal_developmental_patter1.55702482
48MP0002249_abnormal_larynx_morphology1.51285613
49MP0002086_abnormal_extraembryonic_tissu1.50525393
50MP0002332_abnormal_exercise_endurance1.49957124
51MP0000762_abnormal_tongue_morphology1.47857324
52MP0003935_abnormal_craniofacial_develop1.45248883
53MP0003119_abnormal_digestive_system1.44848911
54MP0001730_embryonic_growth_arrest1.42444516
55MP0008007_abnormal_cellular_replicative1.41971601
56MP0000432_abnormal_head_morphology1.38278210
57MP0002233_abnormal_nose_morphology1.36531049
58MP0003755_abnormal_palate_morphology1.36475607
59MP0004272_abnormal_basement_membrane1.34419213
60MP0005171_absent_coat_pigmentation1.34143245
61MP0003941_abnormal_skin_development1.33728468
62MP0005248_abnormal_Harderian_gland1.30879174
63MP0002108_abnormal_muscle_morphology1.30834987
64MP0004185_abnormal_adipocyte_glucose1.29436688
65MP0001697_abnormal_embryo_size1.26736127
66MP0000566_synostosis1.25344590
67MP0002127_abnormal_cardiovascular_syste1.22691255
68MP0005508_abnormal_skeleton_morphology1.21907100
69* MP0002114_abnormal_axial_skeleton1.21525583
70MP0008932_abnormal_embryonic_tissue1.19516728
71MP0002089_abnormal_postnatal_growth/wei1.16086968
72MP0002116_abnormal_craniofacial_bone1.15619093
73MP0004233_abnormal_muscle_weight1.14610389
74MP0008438_abnormal_cutaneous_collagen1.13491454
75MP0003283_abnormal_digestive_organ1.13272966
76MP0003942_abnormal_urinary_system1.12469843
77MP0002925_abnormal_cardiovascular_devel1.11954603
78MP0008789_abnormal_olfactory_epithelium1.11143376
79MP0003115_abnormal_respiratory_system1.09629023
80MP0002111_abnormal_tail_morphology1.09323517
81MP0000767_abnormal_smooth_muscle1.08170933
82* MP0002080_prenatal_lethality1.08138725
83MP0003385_abnormal_body_wall1.07170373
84* MP0003937_abnormal_limbs/digits/tail_de1.07075753
85MP0003315_abnormal_perineum_morphology1.05941420
86MP0009379_abnormal_foot_pigmentation1.04942357
87MP0004133_heterotaxia1.04840663
88MP0000003_abnormal_adipose_tissue1.04617160
89MP0002060_abnormal_skin_morphology1.03914529
90MP0009053_abnormal_anal_canal1.03287717
91MP0009672_abnormal_birth_weight1.03282436
92MP0009250_abnormal_appendicular_skeleto1.02097141
93MP0005076_abnormal_cell_differentiation1.00871491
94MP0005197_abnormal_uvea_morphology1.00847615
95MP0008961_abnormal_basal_metabolism0.99680560
96MP0002396_abnormal_hematopoietic_system0.98903345
97MP0008770_decreased_survivor_rate0.98201342
98MP0001348_abnormal_lacrimal_gland0.95955207
99MP0003693_abnormal_embryo_hatching0.95669857
100MP0005023_abnormal_wound_healing0.95191231
101MP0001286_abnormal_eye_development0.94408282
102MP0000759_abnormal_skeletal_muscle0.93428957
103MP0006035_abnormal_mitochondrial_morpho0.92221208
104MP0009703_decreased_birth_body0.91048337
105MP0001542_abnormal_bone_strength0.90098424
106MP0002938_white_spotting0.89728948
107MP0002160_abnormal_reproductive_system0.89689025
108MP0000313_abnormal_cell_death0.88609868
109MP0002234_abnormal_pharynx_morphology0.87938928
110MP0000537_abnormal_urethra_morphology0.87622431
111MP0005391_vision/eye_phenotype0.87048100
112MP0000733_abnormal_muscle_development0.86119575
113MP0002277_abnormal_respiratory_mucosa0.84423928
114MP0002877_abnormal_melanocyte_morpholog0.83923012
115MP0000462_abnormal_digestive_system0.83350100
116MP0001346_abnormal_lacrimal_gland0.82738133
117MP0003786_premature_aging0.82483805
118MP0002896_abnormal_bone_mineralization0.82459175
119* MP0003861_abnormal_nervous_system0.81964980
120MP0003091_abnormal_cell_migration0.80651745
121MP0000013_abnormal_adipose_tissue0.80509409
122MP0000579_abnormal_nail_morphology0.79985773
123* MP0002697_abnormal_eye_size0.76150848
124MP0000534_abnormal_ureter_morphology0.75364035
125MP0003566_abnormal_cell_adhesion0.74942292
126* MP0002109_abnormal_limb_morphology0.74172977
127MP0002132_abnormal_respiratory_system0.73170890
128MP0000163_abnormal_cartilage_morphology0.72952891
129MP0002970_abnormal_white_adipose0.72609653
130* MP0002081_perinatal_lethality0.72502652
131MP0002098_abnormal_vibrissa_morphology0.71550825
132MP0003787_abnormal_imprinting0.69837931
133MP0000490_abnormal_crypts_of0.69781963
134MP0008058_abnormal_DNA_repair0.69554679

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.98965058
2Rib fusion (HP:0000902)4.71467931
3Hepatoblastoma (HP:0002884)4.45146443
4Ependymoma (HP:0002888)4.28579787
5Abnormality of the lower motor neuron (HP:0002366)4.27097781
6Multiple enchondromatosis (HP:0005701)3.87777507
7Neoplasm of striated muscle (HP:0009728)3.60487322
8Hypochromic microcytic anemia (HP:0004840)3.48441304
9Shallow orbits (HP:0000586)3.47920067
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.46688874
11Astrocytoma (HP:0009592)3.38180517
12Abnormality of the astrocytes (HP:0100707)3.38180517
13Nephroblastoma (Wilms tumor) (HP:0002667)3.27845871
14Rhabdomyosarcoma (HP:0002859)3.18811531
15Renal duplication (HP:0000075)3.18059983
16Ankle contracture (HP:0006466)3.17187637
17Embryonal renal neoplasm (HP:0011794)3.09935395
18Chromsome breakage (HP:0040012)3.07729446
19Abnormality of dentin (HP:0010299)3.07052119
20Short humerus (HP:0005792)2.98314183
21Broad metatarsal (HP:0001783)2.96832045
22Aplasia/hypoplasia of the humerus (HP:0006507)2.96196124
23Bladder diverticulum (HP:0000015)2.90653527
24Fused cervical vertebrae (HP:0002949)2.89371571
25Abnormal lung lobation (HP:0002101)2.86918913
26Hyperacusis (HP:0010780)2.82863791
27Genu recurvatum (HP:0002816)2.81447503
28Short 5th finger (HP:0009237)2.79229184
29Turricephaly (HP:0000262)2.68938659
30Medulloblastoma (HP:0002885)2.65609596
31Biconcave vertebral bodies (HP:0004586)2.64424774
32Broad distal phalanx of finger (HP:0009836)2.63267076
33Spinal rigidity (HP:0003306)2.60318672
34Coronal craniosynostosis (HP:0004440)2.60159946
35Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.60067632
36Trismus (HP:0000211)2.59398834
37Soft skin (HP:0000977)2.58164545
38Fragile skin (HP:0001030)2.57096275
39* Abnormality of the phalanges of the hallux (HP:0010057)2.54813450
40Glioma (HP:0009733)2.54386446
41Bowel diverticulosis (HP:0005222)2.52893794
42Supernumerary ribs (HP:0005815)2.50809723
43Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.48839350
44Short 4th metacarpal (HP:0010044)2.48839350
45Atrophic scars (HP:0001075)2.48180080
46Missing ribs (HP:0000921)2.46402308
47Meckel diverticulum (HP:0002245)2.46401581
48Atresia of the external auditory canal (HP:0000413)2.45425333
49Neoplasm of the heart (HP:0100544)2.42738541
50Selective tooth agenesis (HP:0001592)2.39317692
51Abnormality of the salivary glands (HP:0010286)2.38636749
52Anomalous pulmonary venous return (HP:0010772)2.36375356
53Preauricular pit (HP:0004467)2.35537529
54Periauricular skin pits (HP:0100277)2.35537529
55Shawl scrotum (HP:0000049)2.34610245
56Mitral regurgitation (HP:0001653)2.34372337
57Increased connective tissue (HP:0009025)2.34290029
58Supernumerary spleens (HP:0009799)2.33750675
59Abnormality of the pubic bones (HP:0003172)2.33451186
60Large earlobe (HP:0009748)2.33260281
61Abnormality of the ileum (HP:0001549)2.32560568
62Impulsivity (HP:0100710)2.32038081
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.27921141
64Bowing of the arm (HP:0006488)2.27484988
65Bowed forearm bones (HP:0003956)2.27484988
66Vertebral fusion (HP:0002948)2.26544365
67Neoplasm of the oral cavity (HP:0100649)2.25519286
68Disproportionate tall stature (HP:0001519)2.25021478
69Supernumerary bones of the axial skeleton (HP:0009144)2.24763874
70Aplasia/Hypoplasia of the sternum (HP:0006714)2.24578523
71Pseudobulbar signs (HP:0002200)2.23588717
72Broad long bones (HP:0005622)2.22373428
73Cervical subluxation (HP:0003308)2.22027846
74Aortic dissection (HP:0002647)2.18564716
75Abnormality of the calcaneus (HP:0008364)2.18131119
76Aortic aneurysm (HP:0004942)2.18097960
77Mitral valve prolapse (HP:0001634)2.16831314
78Testicular atrophy (HP:0000029)2.14692033
79Abnormality of chromosome segregation (HP:0002916)2.12801185
80Amyotrophic lateral sclerosis (HP:0007354)2.12124613
81Abnormality of the pulmonary veins (HP:0011718)2.11682206
82Thin ribs (HP:0000883)2.10655847
83Wormian bones (HP:0002645)2.10089301
84Broad finger (HP:0001500)2.08993366
85Broad phalanx (HP:0006009)2.06609210
86Short nail (HP:0001799)2.06583093
87Protrusio acetabuli (HP:0003179)2.05036159
88Aplasia/Hypoplasia of the fovea (HP:0008060)2.04449286
89Hypoplasia of the fovea (HP:0007750)2.04449286
90* Skin tags (HP:0010609)2.04162777
91Hand muscle atrophy (HP:0009130)2.03814347
92Small intestinal stenosis (HP:0012848)2.03679233
93Duodenal stenosis (HP:0100867)2.03679233
94* Preauricular skin tag (HP:0000384)2.03025080
95Joint laxity (HP:0001388)2.02947476
96Skin pits (HP:0100276)2.02669159
97Abnormal cartilage morphology (HP:0002763)2.02578598
98Blue sclerae (HP:0000592)2.02474054
99Facial cleft (HP:0002006)2.00902920
100Short middle phalanx of the 5th finger (HP:0004220)2.00849293
101Overriding aorta (HP:0002623)1.99492924
102Deviation of the hallux (HP:0010051)1.98985340
103Mildly elevated creatine phosphokinase (HP:0008180)1.98820896
104Increased nuchal translucency (HP:0010880)1.98103471
105Spinal cord lesions (HP:0100561)1.98028194
106Syringomyelia (HP:0003396)1.98028194
107Abnormal umbilical cord blood vessels (HP:0011403)1.97660040
108Single umbilical artery (HP:0001195)1.97660040
109Abnormality of the fetal cardiovascular system (HP:0010948)1.97660040
110Broad thumb (HP:0011304)1.97107292
111Calcaneovalgus deformity (HP:0001848)1.97025946
112Malignant neoplasm of the central nervous system (HP:0100836)1.94603143
113Abnormality of the musculature of the hand (HP:0001421)1.94252058
114Glossoptosis (HP:0000162)1.93891364
115Reticulocytopenia (HP:0001896)1.93152765
116Insomnia (HP:0100785)1.93009860
117Dislocated radial head (HP:0003083)1.92667234
118Type 1 muscle fiber predominance (HP:0003803)1.91960031
119* Wide anterior fontanel (HP:0000260)1.91468345
120Abnormality of the 4th metacarpal (HP:0010012)1.90536236
121Mesomelia (HP:0003027)1.89831523
122Vascular tortuosity (HP:0004948)1.89030378
123Hemivertebrae (HP:0002937)1.87517732
124Abnormality of the umbilical cord (HP:0010881)1.85988814
125Increased variability in muscle fiber diameter (HP:0003557)1.85891654
126Spinal muscular atrophy (HP:0007269)1.85174794
127Ragged-red muscle fibers (HP:0003200)1.84294386
128Camptodactyly of toe (HP:0001836)1.83861873
129Abnormality of the aortic arch (HP:0012303)1.83709630
130Achilles tendon contracture (HP:0001771)1.83661644
131Ulnar bowing (HP:0003031)1.83212354
132Vertebral compression fractures (HP:0002953)1.82195965
133Ectopic kidney (HP:0000086)1.81660957
134Hallux valgus (HP:0001822)1.81651552
135Adenoma sebaceum (HP:0009720)1.81049646
136Angiofibromas (HP:0010615)1.81049646
137Flat cornea (HP:0007720)1.80932416
138Elbow flexion contracture (HP:0002987)1.80904811
139Abnormality of the radial head (HP:0003995)1.80749779
140Hypoplastic scapulae (HP:0000882)1.79793315
141Aplasia/Hypoplasia of the scapulae (HP:0006713)1.79793315
142* Abnormality of the distal phalanx of the thumb (HP:0009617)1.79036920
143Abnormality of the acetabulum (HP:0003170)1.78873804
144Renovascular hypertension (HP:0100817)1.78850733
145Premature skin wrinkling (HP:0100678)1.77788164
146Long eyelashes (HP:0000527)1.77656029
147Follicular hyperkeratosis (HP:0007502)1.77317156
148Nonimmune hydrops fetalis (HP:0001790)1.77004373
149Deformed tarsal bones (HP:0008119)1.76372167
150Elfin facies (HP:0004428)1.76071273
151Abnormal number of incisors (HP:0011064)1.75488702
152Broad palm (HP:0001169)1.75176946
153Patellar dislocation (HP:0002999)1.73573440
154Overgrowth (HP:0001548)1.73567038
155Natal tooth (HP:0000695)1.73443129
156Ectopia lentis (HP:0001083)1.73407266
157Cerebral aneurysm (HP:0004944)1.72591914
158Premature rupture of membranes (HP:0001788)1.71975754
159Distal upper limb amyotrophy (HP:0007149)1.71277259
160Upper limb amyotrophy (HP:0009129)1.71277259
161Abnormality of the distal phalanges of the toes (HP:0010182)1.71257092
162Abnormality of the labia minora (HP:0012880)1.71036462
163* Duplication of thumb phalanx (HP:0009942)1.70969469
164Hyperextensible skin (HP:0000974)1.70380375
165Aplasia/Hypoplasia of the macula (HP:0008059)1.69748316
166Arnold-Chiari malformation (HP:0002308)1.69736837
167Nasolacrimal duct obstruction (HP:0000579)1.69573776
168Hypoventilation (HP:0002791)1.69340220
169Abnormality of the duodenum (HP:0002246)1.69204718
170Peritonitis (HP:0002586)1.68399472
171* Partial duplication of the phalanx of hand (HP:0009999)1.68384210
172Neonatal short-limb short stature (HP:0008921)1.68202569
173Abnormal ventriculo-arterial connection (HP:0011563)1.67706547
174Transposition of the great arteries (HP:0001669)1.67706547
175Abnormal connection of the cardiac segments (HP:0011545)1.67706547
176Supernumerary nipples (HP:0002558)1.67576438
177Protruding ear (HP:0000411)1.65753931
178Pendular nystagmus (HP:0012043)1.65034712
179Horizontal nystagmus (HP:0000666)1.64672446
180Abnormality of carpal bone ossification (HP:0006257)1.64664382
181Morphological abnormality of the middle ear (HP:0008609)1.64573271
182Broad phalanges of the hand (HP:0009768)1.64153852
183Fibroma (HP:0010614)1.63604470

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.29963256
2GRK54.00024288
3GRK63.73666243
4ERN13.38712954
5SMG12.90718451
6TYRO32.61205638
7TTK2.55766843
8ADRBK22.47268946
9GRK12.44179560
10MAP3K102.23230223
11CSF1R2.19569663
12STK102.05267191
13CDK71.96980035
14TGFBR21.96096355
15CDC71.87827768
16PAK41.71131192
17CAMK1G1.70646417
18MAPK71.61333099
19NEK21.54625796
20NME21.52934830
21WNK11.52885151
22EPHA21.47280687
23MOS1.46740595
24LATS21.44103984
25CAMK1D1.43265341
26MATK1.38308831
27PLK11.37436750
28CHEK21.34555855
29LATS11.25546619
30WEE11.25237677
31ICK1.20844515
32TRIB31.19746808
33PRKD21.12970121
34ERBB41.12719465
35PNCK1.12088113
36CAMK41.12030326
37CHEK11.10319515
38MET1.10298778
39IRAK31.09428842
40MYLK1.08271136
41GRK71.07997719
42PKN21.07340302
43DDR21.05742100
44BRAF1.05373472
45ALK1.05048977
46PRKG21.05039791
47MTOR1.04595072
48PDGFRA1.03145587
49MARK20.98598816
50ARAF0.98291399
51AKT20.97078287
52CDK40.96050943
53EEF2K0.94788608
54FGFR30.93654651
55DMPK0.92162016
56RPS6KB20.89872077
57BUB10.89368908
58PIM20.88507256
59BRSK10.86694623
60ADRBK10.83860582
61ILK0.83206836
62RPS6KA20.80586088
63BMX0.78160098
64AKT30.77018299
65LMTK20.74647357
66SIK10.74012189
67CDC42BPA0.73598089
68BRD40.73054519
69LIMK10.72871272
70NTRK10.72381552
71STK30.70283260
72CDK20.70128269
73RIPK10.69597904
74VRK20.68796687
75HIPK20.67865201
76DYRK30.65809817
77STK160.65759633
78AURKB0.65642009
79RPS6KL10.65370071
80RPS6KC10.65370071
81DAPK30.64887493
82NEK90.63733631
83CDK90.63564098
84FLT30.62952320
85ATM0.61412908
86ATR0.60376079
87CDK11A0.59582041
88TTN0.58380690
89STK38L0.58319364
90CDK150.57828702
91MKNK10.57011957
92STK40.56665822
93PTK60.56549360
94PLK40.56427027
95TAF10.56175338
96AURKA0.54961843
97PTK20.54895931
98PAK20.54569483
99MST1R0.53984158
100NEK10.53953266
101MAP3K70.53905420
102RPS6KA60.52572395
103PLK30.51078918
104PRKD30.50854499
105RPS6KA40.50627962
106CDK180.50184531
107CDK10.48941977
108PRKCI0.48311693
109CSK0.47320926
110FGFR40.47199166
111PAK10.47105263
112SRPK10.46979174
113ERBB20.46299426
114MAP3K80.45471519
115DYRK1B0.44023330
116MAP2K30.40375646
117MAP2K70.39455398
118DYRK20.39394879
119CDK60.38394658
120FGFR10.36713107
121EIF2AK20.35403646
122PASK0.34415871
123CSNK1E0.33425517
124MAPK10.33215361
125PIM10.32856183
126EPHB20.32367042
127MAPK140.32114049
128GSK3B0.31698389
129INSR0.30778871
130IGF1R0.30671813
131CHUK0.30436578
132PDK30.30405594
133PDK40.30405594
134AKT10.28938417
135CDK80.28188934
136MAP2K60.26966255
137MAPK100.25512531
138TESK20.25201497
139MELK0.24279872
140GSK3A0.23806733
141PDGFRB0.22324922
142MKNK20.21216912

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.01982510
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.74330162
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.60871639
4Basal cell carcinoma_Homo sapiens_hsa052172.53876942
5DNA replication_Homo sapiens_hsa030302.53607655
6RNA transport_Homo sapiens_hsa030132.49396151
7Cell cycle_Homo sapiens_hsa041102.24733452
8Mismatch repair_Homo sapiens_hsa034302.22878440
9mRNA surveillance pathway_Homo sapiens_hsa030152.18661464
10Fructose and mannose metabolism_Homo sapiens_hsa000512.16543945
11One carbon pool by folate_Homo sapiens_hsa006702.12757134
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.02112377
13Spliceosome_Homo sapiens_hsa030401.95781708
14Fanconi anemia pathway_Homo sapiens_hsa034601.92698331
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.92496495
16Hedgehog signaling pathway_Homo sapiens_hsa043401.89027534
17Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.82956700
18Hippo signaling pathway_Homo sapiens_hsa043901.65839958
19Thyroid cancer_Homo sapiens_hsa052161.63608858
20Homologous recombination_Homo sapiens_hsa034401.56885122
21MicroRNAs in cancer_Homo sapiens_hsa052061.56447999
22Base excision repair_Homo sapiens_hsa034101.54601925
23mTOR signaling pathway_Homo sapiens_hsa041501.49001675
24Arachidonic acid metabolism_Homo sapiens_hsa005901.44481816
25Galactose metabolism_Homo sapiens_hsa000521.44241057
26Notch signaling pathway_Homo sapiens_hsa043301.41939157
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.40585715
28Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.36306399
29p53 signaling pathway_Homo sapiens_hsa041151.30792908
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.30173688
31RNA degradation_Homo sapiens_hsa030181.26239658
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21560490
33Pathways in cancer_Homo sapiens_hsa052001.20758262
34Adherens junction_Homo sapiens_hsa045201.20399153
35Proteoglycans in cancer_Homo sapiens_hsa052051.11224279
36Small cell lung cancer_Homo sapiens_hsa052221.09780768
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08967553
38Nucleotide excision repair_Homo sapiens_hsa034201.08110163
39Wnt signaling pathway_Homo sapiens_hsa043101.06759268
40TGF-beta signaling pathway_Homo sapiens_hsa043501.04647845
41Bladder cancer_Homo sapiens_hsa052191.02528370
42Linoleic acid metabolism_Homo sapiens_hsa005911.01944135
43Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00819089
44Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99518882
45HTLV-I infection_Homo sapiens_hsa051660.98419436
46Axon guidance_Homo sapiens_hsa043600.96586865
47Ribosome_Homo sapiens_hsa030100.96398913
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95801231
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95424259
50Colorectal cancer_Homo sapiens_hsa052100.92501523
51ECM-receptor interaction_Homo sapiens_hsa045120.91691700
52Basal transcription factors_Homo sapiens_hsa030220.89983637
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88711592
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87089932
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85783950
56Focal adhesion_Homo sapiens_hsa045100.85333213
57Viral carcinogenesis_Homo sapiens_hsa052030.85185508
58Tight junction_Homo sapiens_hsa045300.84904725
59Non-small cell lung cancer_Homo sapiens_hsa052230.81989001
60Acute myeloid leukemia_Homo sapiens_hsa052210.79957837
61Rap1 signaling pathway_Homo sapiens_hsa040150.79236179
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78895797
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.76424848
64Pyruvate metabolism_Homo sapiens_hsa006200.76374762
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76218512
66Non-homologous end-joining_Homo sapiens_hsa034500.75059066
67Glioma_Homo sapiens_hsa052140.74454149
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.73629586
69PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72587177
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72198944
71N-Glycan biosynthesis_Homo sapiens_hsa005100.72101462
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71416277
73Lysine degradation_Homo sapiens_hsa003100.70962300
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69999904
75Endometrial cancer_Homo sapiens_hsa052130.69808525
76Chronic myeloid leukemia_Homo sapiens_hsa052200.69372837
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69232385
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68811283
79Gap junction_Homo sapiens_hsa045400.67901044
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67076014
81Herpes simplex infection_Homo sapiens_hsa051680.67071340
82Selenocompound metabolism_Homo sapiens_hsa004500.66101361
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65105030
84Protein digestion and absorption_Homo sapiens_hsa049740.63596331
85RNA polymerase_Homo sapiens_hsa030200.62960475
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62749590
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61602560
88Carbon metabolism_Homo sapiens_hsa012000.61557855
89Pancreatic cancer_Homo sapiens_hsa052120.60980686
90Oocyte meiosis_Homo sapiens_hsa041140.60465237
91Systemic lupus erythematosus_Homo sapiens_hsa053220.60132197
92Steroid biosynthesis_Homo sapiens_hsa001000.59035402
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58961773
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56526094
95Amoebiasis_Homo sapiens_hsa051460.56073902
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.55268865
97Folate biosynthesis_Homo sapiens_hsa007900.54698305
98AMPK signaling pathway_Homo sapiens_hsa041520.54164141
99Ovarian steroidogenesis_Homo sapiens_hsa049130.53983069
100Sulfur relay system_Homo sapiens_hsa041220.51358128
101Melanoma_Homo sapiens_hsa052180.50892506
102Biosynthesis of amino acids_Homo sapiens_hsa012300.50224895
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.49212536
104Alcoholism_Homo sapiens_hsa050340.48570988
105Choline metabolism in cancer_Homo sapiens_hsa052310.48377881
106Pyrimidine metabolism_Homo sapiens_hsa002400.47412751
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46573144
108Apoptosis_Homo sapiens_hsa042100.46350897
109Prostate cancer_Homo sapiens_hsa052150.45867188
110Purine metabolism_Homo sapiens_hsa002300.45653721
111Insulin signaling pathway_Homo sapiens_hsa049100.45383707
112Prion diseases_Homo sapiens_hsa050200.44831347
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44641721
114VEGF signaling pathway_Homo sapiens_hsa043700.41780823
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40918146
116Inositol phosphate metabolism_Homo sapiens_hsa005620.40232088
117Dorso-ventral axis formation_Homo sapiens_hsa043200.39039969
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38038293
119Viral myocarditis_Homo sapiens_hsa054160.36803194
120Melanogenesis_Homo sapiens_hsa049160.36593374
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.36536421
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35262845
123HIF-1 signaling pathway_Homo sapiens_hsa040660.34891950
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.34359773
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31028462
126Dilated cardiomyopathy_Homo sapiens_hsa054140.30719815
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30328537
128Pentose phosphate pathway_Homo sapiens_hsa000300.27045520

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