KIFC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the kinesin-14 family of microtubule motors. Members of this family play a role in the formation, maintenance and remodeling of the bipolar mitotic spindle. The protein encoded by this gene has cytoplasmic functions in the interphase cells. It may also be involved in the final stages of cytokinesis. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)4.35902067
2ventricular cardiac muscle cell action potential (GO:0086005)4.31172197
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.10224660
4cell adhesion mediated by integrin (GO:0033627)4.03627370
5negative regulation of potassium ion transmembrane transport (GO:1901380)4.01384593
6sarcomere organization (GO:0045214)3.98551939
7tricarboxylic acid cycle (GO:0006099)3.98397995
8cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.95588027
9lysine metabolic process (GO:0006553)3.84041980
10lysine catabolic process (GO:0006554)3.84041980
11regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.82320448
12bundle of His cell to Purkinje myocyte communication (GO:0086069)3.79296698
13skin morphogenesis (GO:0043589)3.75296172
14cell communication involved in cardiac conduction (GO:0086065)3.74751649
15cell communication by electrical coupling (GO:0010644)3.71044736
16cardiac myofibril assembly (GO:0055003)3.67544354
17NADH metabolic process (GO:0006734)3.57545063
18carnitine shuttle (GO:0006853)3.46809087
19aspartate family amino acid catabolic process (GO:0009068)3.40930715
20regulation of hippo signaling (GO:0035330)3.40831466
212-oxoglutarate metabolic process (GO:0006103)3.35949022
22endodermal cell differentiation (GO:0035987)3.34290152
23regulation of early endosome to late endosome transport (GO:2000641)3.32882590
24barbed-end actin filament capping (GO:0051016)3.32256936
25positive regulation of osteoblast proliferation (GO:0033690)3.25259219
26cardiac muscle contraction (GO:0060048)3.23215103
27basement membrane organization (GO:0071711)3.17794881
28positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.17780470
29amino-acid betaine transport (GO:0015838)3.13091469
30carnitine transport (GO:0015879)3.13091469
31fatty acid transmembrane transport (GO:1902001)3.12305080
32regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.12042218
33sodium ion export (GO:0071436)3.08765709
34cytoskeletal anchoring at plasma membrane (GO:0007016)3.06847216
35regulation of cardioblast differentiation (GO:0051890)3.06624990
36tricarboxylic acid metabolic process (GO:0072350)3.06291156
37COPI coating of Golgi vesicle (GO:0048205)3.05551302
38Golgi transport vesicle coating (GO:0048200)3.05551302
39endothelial cell chemotaxis (GO:0035767)3.05222481
40positive regulation of receptor recycling (GO:0001921)3.04336445
41heart trabecula formation (GO:0060347)3.01921344
42carnitine transmembrane transport (GO:1902603)3.00782960
43regulation of cholesterol homeostasis (GO:2000188)2.98080710
44low-density lipoprotein particle clearance (GO:0034383)2.95848042
45cardiac muscle cell development (GO:0055013)2.94899659
46regulation of tight junction assembly (GO:2000810)2.92790894
47response to magnesium ion (GO:0032026)2.91852606
48negative regulation of fatty acid transport (GO:2000192)2.89283937
49regulation of fatty acid oxidation (GO:0046320)2.88720702
50mannose metabolic process (GO:0006013)2.87678896
51biotin metabolic process (GO:0006768)2.87623373
52cellular response to thyroid hormone stimulus (GO:0097067)2.86651738
534-hydroxyproline metabolic process (GO:0019471)2.85788126
54adhesion of symbiont to host (GO:0044406)2.85521322
55myofibril assembly (GO:0030239)2.85472001
56wound healing, spreading of epidermal cells (GO:0035313)2.84470028
57semaphorin-plexin signaling pathway (GO:0071526)2.83768941
58cardiac muscle cell action potential involved in contraction (GO:0086002)2.83706234
59positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.82523322
60regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.82059200
61adhesion of symbiont to host cell (GO:0044650)2.81912336
62virion attachment to host cell (GO:0019062)2.81912336
63fatty acid beta-oxidation (GO:0006635)2.81443665
64regulation of membrane repolarization (GO:0060306)2.81107431
65cardiac muscle cell action potential (GO:0086001)2.80842834
66positive regulation of extracellular matrix organization (GO:1903055)2.80431112
67regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.79961517
68cell-substrate adherens junction assembly (GO:0007045)2.79878250
69focal adhesion assembly (GO:0048041)2.79878250
70retina vasculature morphogenesis in camera-type eye (GO:0061299)2.77441280
71membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.76052244
72cardiac cell development (GO:0055006)2.75633325
73hyaluronan catabolic process (GO:0030214)2.74240929
74regulation of membrane protein ectodomain proteolysis (GO:0051043)2.74105713
75negative regulation of cell size (GO:0045792)2.69515021
76protein retention in ER lumen (GO:0006621)2.69405214
77response to thyroid hormone (GO:0097066)2.69324481
78actomyosin structure organization (GO:0031032)2.69248945
79maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.67937678
80glomerular visceral epithelial cell development (GO:0072015)2.65851944
81vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.65323290
82regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.64791272
83collagen metabolic process (GO:0032963)2.64777292
84quaternary ammonium group transport (GO:0015697)2.64191962
85actin filament depolymerization (GO:0030042)2.63501785
86surfactant homeostasis (GO:0043129)2.63149901
87atrioventricular valve morphogenesis (GO:0003181)2.63148825
88positive regulation of sodium ion transport (GO:0010765)2.62860429
89regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.62194926
90CDP-diacylglycerol metabolic process (GO:0046341)2.60908106
91glomerular basement membrane development (GO:0032836)2.60794949
92dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.60487723
93phosphate ion transport (GO:0006817)2.60242697
94positive regulation of triglyceride biosynthetic process (GO:0010867)2.59348634
95apoptotic cell clearance (GO:0043277)2.58309358
96peptidyl-proline hydroxylation (GO:0019511)2.58234026
97glial cell migration (GO:0008347)2.55641482
98protein localization to endosome (GO:0036010)2.55126333
99regulation of actin filament-based movement (GO:1903115)2.55090445
100collagen catabolic process (GO:0030574)2.54838793
101phosphate ion transmembrane transport (GO:0035435)2.54823638
102multicellular organismal macromolecule metabolic process (GO:0044259)2.54762721
103activation of Rac GTPase activity (GO:0032863)2.54574418
104glycosphingolipid catabolic process (GO:0046479)2.53976866
105positive regulation of blood vessel endothelial cell migration (GO:0043536)2.53523559
106pinocytosis (GO:0006907)2.52642212
107positive regulation of endothelial cell apoptotic process (GO:2000353)2.51444351
108mesodermal cell differentiation (GO:0048333)2.51389881
109regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.50907835
110regulation of fatty acid beta-oxidation (GO:0031998)2.50514026
111endothelial cell morphogenesis (GO:0001886)2.50256084
112response to laminar fluid shear stress (GO:0034616)2.50184853
113protein hydroxylation (GO:0018126)2.49817017
114response to mercury ion (GO:0046689)2.47362633
115fatty acid catabolic process (GO:0009062)2.46068020
116amino-acid betaine metabolic process (GO:0006577)2.45709646
117endocytic recycling (GO:0032456)2.45638115
118alanine transport (GO:0032328)2.45628757
119substrate-dependent cell migration (GO:0006929)2.45532673
120acetyl-CoA metabolic process (GO:0006084)2.45517779
121multicellular organismal metabolic process (GO:0044236)2.43754730
122multicellular organismal catabolic process (GO:0044243)2.43654274
123cell-substrate junction assembly (GO:0007044)2.43516551
124membrane repolarization during action potential (GO:0086011)2.43191742
125CDP-diacylglycerol biosynthetic process (GO:0016024)2.42762515
126extracellular matrix disassembly (GO:0022617)2.42731883
127stress fiber assembly (GO:0043149)2.42556358
128hemidesmosome assembly (GO:0031581)2.42089659
129fatty acid oxidation (GO:0019395)2.41992152
130alpha-linolenic acid metabolic process (GO:0036109)2.41963112
131lipid oxidation (GO:0034440)2.41719125
132regulation of the force of heart contraction (GO:0002026)2.41613576
133lung epithelium development (GO:0060428)2.40784505
134potassium ion import (GO:0010107)2.40583511
135cardiac muscle hypertrophy (GO:0003300)2.40482348
136short-chain fatty acid metabolic process (GO:0046459)2.40130633
137decidualization (GO:0046697)2.38270121
138regulation of apoptotic process involved in morphogenesis (GO:1902337)2.38136192
139fatty acid homeostasis (GO:0055089)2.37392759
140growth hormone secretion (GO:0030252)2.37358612
141* epithelial cell-cell adhesion (GO:0090136)2.36906585
142wound healing, spreading of cells (GO:0044319)2.36472254
143regulation of acyl-CoA biosynthetic process (GO:0050812)2.36093505
144adherens junction assembly (GO:0034333)2.33809038
145regulation of heart rate by cardiac conduction (GO:0086091)2.33246833
146vascular endothelial growth factor signaling pathway (GO:0038084)2.32932345
147regulation of integrin activation (GO:0033623)2.32845404
148negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.32583732
149desmosome organization (GO:0002934)2.32517105
150positive regulation of fatty acid beta-oxidation (GO:0032000)2.32252690
151dicarboxylic acid biosynthetic process (GO:0043650)2.31853011
152positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.31770522
153response to parathyroid hormone (GO:0071107)2.30883716
154glycolipid catabolic process (GO:0019377)2.30240313
155retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.30198770
156cell migration involved in sprouting angiogenesis (GO:0002042)2.29735571
157striated muscle hypertrophy (GO:0014897)2.29649807
158carnitine metabolic process (GO:0009437)2.29590730
159cell volume homeostasis (GO:0006884)2.29140535
160cysteine metabolic process (GO:0006534)2.28979953
161regulation of p38MAPK cascade (GO:1900744)2.28404738
162regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.28366597
163regulation of cofactor metabolic process (GO:0051193)2.27867955
164regulation of coenzyme metabolic process (GO:0051196)2.27867955
165hypotonic response (GO:0006971)2.27801338
166glomerular epithelial cell development (GO:0072310)2.27344613
167cellular modified amino acid catabolic process (GO:0042219)2.27104961
168negative regulation of nitric oxide biosynthetic process (GO:0045019)2.26784181
169protein heterotrimerization (GO:0070208)2.26212038
170negative regulation of focal adhesion assembly (GO:0051895)2.25164629
171negative regulation of cell junction assembly (GO:1901889)2.25164629
172negative regulation of adherens junction organization (GO:1903392)2.25164629
173regulation of glucose import in response to insulin stimulus (GO:2001273)2.24452779
174negative regulation of protein localization to cell surface (GO:2000009)2.23552467
175macroautophagy (GO:0016236)2.23397054
176negative regulation of smooth muscle cell migration (GO:0014912)2.22172425
177regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.21941299
178peptidyl-glutamic acid carboxylation (GO:0017187)2.21373721
179protein carboxylation (GO:0018214)2.21373721
180sphingosine metabolic process (GO:0006670)2.21001052
181positive regulation of p38MAPK cascade (GO:1900745)2.19513261
182positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.17647521
183membrane protein ectodomain proteolysis (GO:0006509)2.17330773
184angiogenesis involved in wound healing (GO:0060055)2.15867788
185planar cell polarity pathway involved in neural tube closure (GO:0090179)2.15648497

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.88879860
2* ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.24135653
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.11777863
4ZNF263_19887448_ChIP-Seq_K562_Human2.97530245
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.67240318
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.63844514
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.43156980
8CLOCK_20551151_ChIP-Seq_293T_Human2.38132839
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.37031640
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.32402888
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.31545425
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23420072
13* LXR_22158963_ChIP-Seq_LIVER_Mouse2.20959465
14ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.19045996
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.15553939
16EP300_21415370_ChIP-Seq_HL-1_Mouse2.00446396
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.98317771
18TBX20_22080862_ChIP-Seq_HEART_Mouse1.88484436
19TBX20_22328084_ChIP-Seq_HEART_Mouse1.88484436
20GATA2_21666600_ChIP-Seq_HMVEC_Human1.86743597
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.83914402
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81539840
23SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.80285799
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.79908779
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.74601075
26* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.71537141
27* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.71537141
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.68270393
29* LXR_22292898_ChIP-Seq_THP-1_Human1.67918394
30RACK7_27058665_Chip-Seq_MCF-7_Human1.64175079
31TP53_22127205_ChIP-Seq_IMR90_Human1.63662766
32* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.56198095
33JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55388172
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55343829
35KDM2B_26808549_Chip-Seq_K562_Human1.55016181
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54359306
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52352799
38JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50502022
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49921506
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.47954006
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.47579200
42DROSHA_22980978_ChIP-Seq_HELA_Human1.47147108
43P63_26484246_Chip-Seq_KERATINOCYTES_Human1.44201062
44CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.43255128
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42247060
46* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.41892844
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41341742
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.37354313
49* UBF1/2_26484160_Chip-Seq_HMECs_Human1.37109256
50* RUNX1_27514584_Chip-Seq_MCF-7_Human1.35776829
51* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35731975
52* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34983967
53CJUN_26792858_Chip-Seq_BT549_Human1.32480679
54* ATF3_27146783_Chip-Seq_COLON_Human1.31526880
55CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31131730
56VDR_21846776_ChIP-Seq_THP-1_Human1.29979561
57P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28883362
58* FOXA2_19822575_ChIP-Seq_HepG2_Human1.27153930
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25228739
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25119050
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.24830509
62* TP63_22573176_ChIP-Seq_HFKS_Human1.24347987
63TCF7_22412390_ChIP-Seq_EML_Mouse1.23657383
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23520825
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23367898
66TP53_23651856_ChIP-Seq_MEFs_Mouse1.23168188
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.23106706
68CREB1_26743006_Chip-Seq_LNCaP_Human1.21197169
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21149891
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20385326
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17672065
72SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16237373
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15519744
74KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15491458
75KDM2B_26808549_Chip-Seq_DND41_Human1.14161917
76PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.12900499
77SMC4_20622854_ChIP-Seq_HELA_Human1.12468984
78CTCF_27219007_Chip-Seq_Bcells_Human1.12066416
79* TET1_21490601_ChIP-Seq_MESCs_Mouse1.12019947
80P68_20966046_ChIP-Seq_HELA_Human1.11217091
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.10720252
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09985581
83EGR1_19374776_ChIP-ChIP_THP-1_Human1.09322571
84* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08480068
85CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08106270
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.06850295
87MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06575411
88SMC1_22415368_ChIP-Seq_MEFs_Mouse1.06522552
89SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06264469
90ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.06067246
91ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05967114
92* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04523121
93* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03306509
94* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03163902
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03063453
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02842292
97NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02841267
98KLF5_25053715_ChIP-Seq_YYC3_Human1.02320164
99CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01753915
100ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01209212
101GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.00511994
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00028344
103* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99956897
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99708559
105* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99257560
106FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99058106
107POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99013192
108RARB_27405468_Chip-Seq_BRAIN_Mouse0.98759929
109* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98751903
110SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98292673
111* BRD4_25478319_ChIP-Seq_HGPS_Human0.98247134
112ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98218183
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97473504
114KLF4_19829295_ChIP-Seq_ESCs_Human0.96944144
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96350922
116ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95388689
117SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95222604
118RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94717368
119* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93479333
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93359912
121SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93308259
122TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93090155
123HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92777202
124SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92523509
125ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91508005
126EZH2_18974828_ChIP-Seq_MESCs_Mouse0.90803705
127RNF2_18974828_ChIP-Seq_MESCs_Mouse0.90803705
128* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90800358
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90082071
130GATA1_19941826_ChIP-Seq_K562_Human0.89591626
131ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89394966
132TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.89201708
133* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89125788
134CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87471435
135TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87398012
136SMAD3_21741376_ChIP-Seq_HESCs_Human0.87260439
137MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.87134011
138AHR_22903824_ChIP-Seq_MCF-7_Human0.86644165

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.75033220
2MP0004084_abnormal_cardiac_muscle3.68935137
3MP0000751_myopathy3.29128732
4MP0005058_abnormal_lysosome_morphology3.28964009
5MP0003705_abnormal_hypodermis_morpholog3.12353360
6MP0003646_muscle_fatigue2.97982035
7MP0002138_abnormal_hepatobiliary_system2.83037697
8MP0005257_abnormal_intraocular_pressure2.72945877
9MP0004215_abnormal_myocardial_fiber2.51970071
10MP0002877_abnormal_melanocyte_morpholog2.40036449
11MP0005330_cardiomyopathy2.36936429
12MP0004036_abnormal_muscle_relaxation2.35820323
13MP0002139_abnormal_hepatobiliary_system2.30605887
14MP0003453_abnormal_keratinocyte_physiol2.13861000
15MP0005023_abnormal_wound_healing2.09838715
16MP0003252_abnormal_bile_duct2.08428252
17MP0000750_abnormal_muscle_regeneration1.98763058
18MP0004130_abnormal_muscle_cell1.98304151
19MP0010234_abnormal_vibrissa_follicle1.92543921
20MP0006138_congestive_heart_failure1.90149109
21MP0002972_abnormal_cardiac_muscle1.85945880
22MP0004087_abnormal_muscle_fiber1.85800691
23MP0003329_amyloid_beta_deposits1.85073273
24MP0004272_abnormal_basement_membrane1.83702165
25MP0009840_abnormal_foam_cell1.82221852
26MP0004510_myositis1.81963478
27MP0002269_muscular_atrophy1.79698438
28MP0003283_abnormal_digestive_organ1.78350545
29MP0009780_abnormal_chondrocyte_physiolo1.77426892
30MP0002909_abnormal_adrenal_gland1.72021371
31MP0003137_abnormal_impulse_conducting1.66745034
32MP0005451_abnormal_body_composition1.66652135
33MP0005360_urolithiasis1.65420235
34MP0006054_spinal_hemorrhage1.64341573
35MP0008775_abnormal_heart_ventricle1.63769938
36MP0005666_abnormal_adipose_tissue1.63623578
37MP0005623_abnormal_meninges_morphology1.62357588
38MP0005670_abnormal_white_adipose1.61305691
39MP0003566_abnormal_cell_adhesion1.60856432
40MP0005409_darkened_coat_color1.60761429
41MP0004043_abnormal_pH_regulation1.60303161
42MP0010630_abnormal_cardiac_muscle1.60087107
43MP0005332_abnormal_amino_acid1.59843310
44MP0001544_abnormal_cardiovascular_syste1.59767466
45MP0005385_cardiovascular_system_phenoty1.59767466
46MP0000749_muscle_degeneration1.58602963
47MP0004233_abnormal_muscle_weight1.56988534
48MP0005076_abnormal_cell_differentiation1.56508621
49MP0005620_abnormal_muscle_contractility1.55367831
50MP0002998_abnormal_bone_remodeling1.55158385
51MP0003172_abnormal_lysosome_physiology1.54990952
52MP0009278_abnormal_bone_marrow1.52201310
53MP0001958_emphysema1.51965919
54MP0000858_altered_metastatic_potential1.51479909
55MP0000343_altered_response_to1.46452822
56MP0002060_abnormal_skin_morphology1.44930388
57MP0002928_abnormal_bile_duct1.44857976
58MP0000747_muscle_weakness1.44424651
59MP0005595_abnormal_vascular_smooth1.43342641
60MP0010368_abnormal_lymphatic_system1.40875682
61MP0005365_abnormal_bile_salt1.40062121
62MP0005083_abnormal_biliary_tract1.39752048
63MP0000678_abnormal_parathyroid_gland1.38185973
64MP0004484_altered_response_of1.35641607
65MP0000013_abnormal_adipose_tissue1.35555072
66MP0004085_abnormal_heartbeat1.35443236
67MP0003300_gastrointestinal_ulcer1.35039293
68MP0005084_abnormal_gallbladder_morpholo1.34770767
69MP0003045_fibrosis1.34532659
70MP0005275_abnormal_skin_tensile1.32009922
71MP0000767_abnormal_smooth_muscle1.32006993
72MP0003195_calcinosis1.30466387
73MP0005167_abnormal_blood-brain_barrier1.29769265
74MP0005375_adipose_tissue_phenotype1.28840359
75MP0004185_abnormal_adipocyte_glucose1.28697682
76MP0004858_abnormal_nervous_system1.26381299
77MP0008961_abnormal_basal_metabolism1.22778646
78MP0003279_aneurysm1.21301499
79MP0005085_abnormal_gallbladder_physiolo1.19433019
80MP0003879_abnormal_hair_cell1.18967830
81MP0006082_CNS_inflammation1.16923745
82MP0001348_abnormal_lacrimal_gland1.16870820
83MP0008438_abnormal_cutaneous_collagen1.16103210
84MP0001756_abnormal_urination1.14857373
85MP0001666_abnormal_nutrient_absorption1.14840382
86MP0009643_abnormal_urine_homeostasis1.13131543
87MP0005164_abnormal_response_to1.13120943
88MP0004947_skin_inflammation1.12659052
89MP0002106_abnormal_muscle_physiology1.12187852
90MP0003075_altered_response_to1.12151558
91MP0002796_impaired_skin_barrier1.12140167
92MP0004885_abnormal_endolymph1.12078845
93MP0002089_abnormal_postnatal_growth/wei1.11013105
94MP0003878_abnormal_ear_physiology1.10415211
95MP0005377_hearing/vestibular/ear_phenot1.10415211
96MP0010352_gastrointestinal_tract_polyps1.09431167
97MP0005503_abnormal_tendon_morphology1.09142345
98MP0005165_increased_susceptibility_to1.08550898
99MP0008260_abnormal_autophagy1.05757875
100MP0000003_abnormal_adipose_tissue1.03624235
101MP0002234_abnormal_pharynx_morphology1.02564734
102MP0010329_abnormal_lipoprotein_level1.01736374
103MP0001765_abnormal_ion_homeostasis1.01652263
104MP0005464_abnormal_platelet_physiology1.00753250
105MP0009384_cardiac_valve_regurgitation1.00513942
106MP0003191_abnormal_cellular_cholesterol0.98564378
107MP0002118_abnormal_lipid_homeostasis0.97932379
108MP0005501_abnormal_skin_physiology0.95553224
109MP0002168_other_aberrant_phenotype0.94955311
110MP0005369_muscle_phenotype0.93399060
111MP0000759_abnormal_skeletal_muscle0.92998582
112MP0002127_abnormal_cardiovascular_syste0.92322533
113MP0000733_abnormal_muscle_development0.92277808
114MP0003221_abnormal_cardiomyocyte_apopto0.91597661
115MP0004859_abnormal_synaptic_plasticity0.91104366
116MP0001915_intracranial_hemorrhage0.89616051
117MP0004019_abnormal_vitamin_homeostasis0.89314255
118MP0003634_abnormal_glial_cell0.86776600
119MP0001216_abnormal_epidermal_layer0.86119969
120MP0004782_abnormal_surfactant_physiolog0.85413808
121MP0002295_abnormal_pulmonary_circulatio0.84471475
122MP0001243_abnormal_dermal_layer0.83667401
123MP0000230_abnormal_systemic_arterial0.83586879
124MP0003448_altered_tumor_morphology0.82960673
125MP0000604_amyloidosis0.82858381
126MP0001849_ear_inflammation0.82471162
127MP0000579_abnormal_nail_morphology0.82464310
128MP0001533_abnormal_skeleton_physiology0.82419318
129MP0002332_abnormal_exercise_endurance0.81938932
130MP0005508_abnormal_skeleton_morphology0.81921055
131MP0003183_abnormal_peptide_metabolism0.81523190
132MP0000249_abnormal_blood_vessel0.80594771
133MP0000681_abnormal_thyroid_gland0.80477265
134MP0002896_abnormal_bone_mineralization0.78890613
135MP0003656_abnormal_erythrocyte_physiolo0.77434113
136MP0003436_decreased_susceptibility_to0.77309729
137MP0005397_hematopoietic_system_phenotyp0.77124812
138MP0001545_abnormal_hematopoietic_system0.77124812
139MP0000266_abnormal_heart_morphology0.76185824
140MP0005171_absent_coat_pigmentation0.75088720
141MP0005319_abnormal_enzyme/_coenzyme0.74959256
142MP0010771_integument_phenotype0.74931560
143MP0009053_abnormal_anal_canal0.73922809
144MP0001661_extended_life_span0.73618372
145MP0003828_pulmonary_edema0.72760835
146MP0000920_abnormal_myelination0.72598961
147MP0005197_abnormal_uvea_morphology0.72457787
148MP0000537_abnormal_urethra_morphology0.72364657
149MP0010030_abnormal_orbit_morphology0.71954886
150MP0006036_abnormal_mitochondrial_physio0.69671707
151MP0001614_abnormal_blood_vessel0.69629110
152MP0005220_abnormal_exocrine_pancreas0.68831028
153MP0002078_abnormal_glucose_homeostasis0.67356768
154MP0003950_abnormal_plasma_membrane0.67251342
155MP0003690_abnormal_glial_cell0.66876918
156MP0005187_abnormal_penis_morphology0.65597244
157MP0003091_abnormal_cell_migration0.65189329

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)4.69254656
2Right ventricular cardiomyopathy (HP:0011663)4.41055050
3Sudden death (HP:0001699)4.39060414
4Muscle fiber splitting (HP:0003555)4.15221732
5Bundle branch block (HP:0011710)4.01771741
6Ventricular tachycardia (HP:0004756)3.97609387
7Ventricular fibrillation (HP:0001663)3.64652370
8Atrophic scars (HP:0001075)3.27553814
9Abnormality of glycolipid metabolism (HP:0010969)3.26950665
10Abnormality of liposaccharide metabolism (HP:0010968)3.26950665
11Abnormality of glycosphingolipid metabolism (HP:0004343)3.26950665
12Hyperglycinuria (HP:0003108)3.26426559
13Atrioventricular block (HP:0001678)3.25817087
14Syncope (HP:0001279)3.24773604
15Ketoacidosis (HP:0001993)3.23238475
16Hyporeflexia of lower limbs (HP:0002600)3.20950990
17Increased connective tissue (HP:0009025)3.19389379
18Vertebral compression fractures (HP:0002953)3.15941965
19Ventricular arrhythmia (HP:0004308)3.03022368
20Atrial fibrillation (HP:0005110)3.01439783
21Heart block (HP:0012722)3.01035029
22Myoglobinuria (HP:0002913)3.00867467
23Difficulty climbing stairs (HP:0003551)3.00248579
24Exercise-induced myalgia (HP:0003738)3.00095023
25Neurofibrillary tangles (HP:0002185)2.99357455
26Abnormal atrioventricular conduction (HP:0005150)2.95324712
27Asymmetric septal hypertrophy (HP:0001670)2.91724041
28Dysostosis multiplex (HP:0000943)2.91417324
29Distal lower limb amyotrophy (HP:0008944)2.90779606
30Neonatal death (HP:0003811)2.84159644
31Ulnar bowing (HP:0003031)2.83254806
32Fragile skin (HP:0001030)2.81912257
33Primary atrial arrhythmia (HP:0001692)2.81865582
34Exercise-induced muscle cramps (HP:0003710)2.80040273
35Nuclear cataract (HP:0100018)2.77935083
36Cervical subluxation (HP:0003308)2.77181349
37Cerebral aneurysm (HP:0004944)2.76939479
38Broad face (HP:0000283)2.76469967
39Abnormality of polysaccharide metabolism (HP:0011012)2.75260952
40Abnormality of glycosaminoglycan metabolism (HP:0004371)2.75260952
41Abnormality of mucopolysaccharide metabolism (HP:0011020)2.75260952
42Myocardial infarction (HP:0001658)2.74487120
43Mucopolysacchariduria (HP:0008155)2.73460121
44Urinary glycosaminoglycan excretion (HP:0003541)2.73460121
45Abnormality of glycine metabolism (HP:0010895)2.72276614
46Abnormality of serine family amino acid metabolism (HP:0010894)2.72276614
47Potter facies (HP:0002009)2.71196091
48Facial shape deformation (HP:0011334)2.71196091
49Supraventricular arrhythmia (HP:0005115)2.71164473
50Difficulty running (HP:0009046)2.69448090
51Hypoglycemic coma (HP:0001325)2.67722537
52Achilles tendon contracture (HP:0001771)2.64152470
53Supraventricular tachycardia (HP:0004755)2.63754290
54Thin bony cortex (HP:0002753)2.60822962
55Increased cerebral lipofuscin (HP:0011813)2.59499735
56Hyperuricemia (HP:0002149)2.59399958
57Increased purine levels (HP:0004368)2.59399958
58Ketosis (HP:0001946)2.57575568
59Arterial tortuosity (HP:0005116)2.54409695
60Wormian bones (HP:0002645)2.53422650
61Prolonged QT interval (HP:0001657)2.51992181
62Abnormality of the calf musculature (HP:0001430)2.50851929
63Interstitial pulmonary disease (HP:0006530)2.50441281
64Shallow orbits (HP:0000586)2.49251988
65Natal tooth (HP:0000695)2.49101095
66Abnormality of the Achilles tendon (HP:0005109)2.48829263
67Palpitations (HP:0001962)2.48711310
68Aortic dissection (HP:0002647)2.48550850
69Vascular tortuosity (HP:0004948)2.48502954
70Axonal loss (HP:0003447)2.47753589
71Lipoatrophy (HP:0100578)2.46574482
72Osteolytic defects of the hand bones (HP:0009699)2.45628418
73Osteolytic defects of the phalanges of the hand (HP:0009771)2.45628418
74Spinal rigidity (HP:0003306)2.44575740
75Lymphangioma (HP:0100764)2.42384320
76Broad metatarsal (HP:0001783)2.39574139
77Aortic aneurysm (HP:0004942)2.39095851
78Hyperacusis (HP:0010780)2.38793857
79Mitral stenosis (HP:0001718)2.36212498
80Increased circulating renin level (HP:0000848)2.34010906
81Bronchomalacia (HP:0002780)2.32041453
82Premature rupture of membranes (HP:0001788)2.30736924
83Increased neuronal autofluorescent lipopigment (HP:0002074)2.30122084
84Calf muscle hypertrophy (HP:0008981)2.28547006
85Elbow flexion contracture (HP:0002987)2.27851541
86Hyperglycinemia (HP:0002154)2.26490356
87J-shaped sella turcica (HP:0002680)2.25844573
88Late onset (HP:0003584)2.20316226
89Hyperglycemia (HP:0003074)2.19428640
90Focal segmental glomerulosclerosis (HP:0000097)2.19421968
91Bladder diverticulum (HP:0000015)2.17976179
92Blue sclerae (HP:0000592)2.17746938
93Upper limb amyotrophy (HP:0009129)2.16860272
94Distal upper limb amyotrophy (HP:0007149)2.16860272
95Esophageal varix (HP:0002040)2.14225276
96Abnormality of fatty-acid metabolism (HP:0004359)2.14152213
97Systemic lupus erythematosus (HP:0002725)2.12168150
98Abnormality of complement system (HP:0005339)2.11851906
99Joint stiffness (HP:0001387)2.09543619
100Turricephaly (HP:0000262)2.08883814
101Hypokalemic alkalosis (HP:0001949)2.07869805
102Dilated cardiomyopathy (HP:0001644)2.07456254
103Malnutrition (HP:0004395)2.07080804
104Mitral regurgitation (HP:0001653)2.06932520
105EMG: myopathic abnormalities (HP:0003458)2.06864691
106Polycythemia (HP:0001901)2.06428436
107Protrusio acetabuli (HP:0003179)2.06251554
108Hemorrhage of the eye (HP:0011885)2.04700097
109Stridor (HP:0010307)2.03808071
110Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.03755827
111Xanthomatosis (HP:0000991)2.03631645
112Hyperinsulinemic hypoglycemia (HP:0000825)2.03587383
113Lower limb amyotrophy (HP:0007210)1.99285914
114Hyperammonemia (HP:0001987)1.98657468
115Abnormality of purine metabolism (HP:0004352)1.97391377
116Aplasia involving bones of the upper limbs (HP:0009823)1.96985706
117Aplasia of the phalanges of the hand (HP:0009802)1.96985706
118Aplasia involving bones of the extremities (HP:0009825)1.96985706
119Spondylolisthesis (HP:0003302)1.96208668
120Hand muscle atrophy (HP:0009130)1.94962029
121Mildly elevated creatine phosphokinase (HP:0008180)1.93964555
122Aneurysm (HP:0002617)1.93429055
123Menorrhagia (HP:0000132)1.92801193
124Athetosis (HP:0002305)1.90327632
125Abnormal EKG (HP:0003115)1.90120953
126Loss of speech (HP:0002371)1.89510264
127Enlarged penis (HP:0000040)1.88987306
128Visceral angiomatosis (HP:0100761)1.88459262
129Renal salt wasting (HP:0000127)1.88169484
130Follicular hyperkeratosis (HP:0007502)1.87892584
131Cardiovascular calcification (HP:0011915)1.87300103
132Thick nail (HP:0001805)1.86829432
133Complement deficiency (HP:0004431)1.86710882
134Abnormality of the distal phalanges of the toes (HP:0010182)1.86547440
135Aortic regurgitation (HP:0001659)1.84435261
136Hypoalphalipoproteinemia (HP:0003233)1.84156922
137Alopecia of scalp (HP:0002293)1.83560280
138Hamartoma of the eye (HP:0010568)1.83249692
139Muscle hypertrophy of the lower extremities (HP:0008968)1.82983110
140Abnormal urine output (HP:0012590)1.82010500
141Abnormality of monocarboxylic acid metabolism (HP:0010996)1.81126994
142Distal lower limb muscle weakness (HP:0009053)1.79530308
143Global brain atrophy (HP:0002283)1.78765715
144Short nail (HP:0001799)1.78667355
145Hydroxyprolinuria (HP:0003080)1.78110120
146Abnormality of proline metabolism (HP:0010907)1.78110120
147Dilatation of the ascending aorta (HP:0005111)1.77343728
148Soft skin (HP:0000977)1.76220115
149Increased mean platelet volume (HP:0011877)1.76022626
150Flat acetabular roof (HP:0003180)1.75217339
151Deep venous thrombosis (HP:0002625)1.74810337
152Increased variability in muscle fiber diameter (HP:0003557)1.74760277
153Vacuolated lymphocytes (HP:0001922)1.74613719
154Myotonia (HP:0002486)1.74387331
155Dicarboxylic aciduria (HP:0003215)1.74312223
156Abnormality of dicarboxylic acid metabolism (HP:0010995)1.74312223
157Rhabdomyolysis (HP:0003201)1.74257302
158Neonatal short-limb short stature (HP:0008921)1.74249246
159Glomerulosclerosis (HP:0000096)1.73702680
160Mitral valve prolapse (HP:0001634)1.73648024
161Abnormality of renal excretion (HP:0011036)1.73502374
162Hemangiomatosis (HP:0007461)1.72981055
163Cerebral inclusion bodies (HP:0100314)1.72713813
164Disproportionate tall stature (HP:0001519)1.72691882
165Limb-girdle muscle atrophy (HP:0003797)1.71751391
166Vascular calcification (HP:0004934)1.71485067
167Ankle contracture (HP:0006466)1.71364614
168Retinal atrophy (HP:0001105)1.70896429
169Abnormality of the acetabulum (HP:0003170)1.70775394
170Hyperactive renin-angiotensin system (HP:0000841)1.70374358
171Zonular cataract (HP:0010920)1.70336913
172Subaortic stenosis (HP:0001682)1.70228770
173Abnormality of the left ventricular outflow tract (HP:0011103)1.70228770
174Polyuria (HP:0000103)1.70001237
175Onion bulb formation (HP:0003383)1.69416504
176Advanced eruption of teeth (HP:0006288)1.68872567
177Abnormality of the lower motor neuron (HP:0002366)1.68430583
178Glomerulonephritis (HP:0000099)1.68404632
179Long toe (HP:0010511)1.66455031
180Rapidly progressive (HP:0003678)1.65670039

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.54511299
2IRAK34.09242109
3LMTK23.36250522
4TTN3.30377469
5PDK32.92986310
6PDK42.92986310
7PKN22.62896740
8PHKG12.38479243
9PHKG22.38479243
10RIPK12.38294479
11EPHA22.31337165
12PRKD32.28586475
13NME22.22177615
14WNK42.05495975
15BCKDK1.94916669
16LATS21.87653822
17PDGFRA1.86897952
18NEK11.81327147
19PDK21.80013830
20MAP3K91.73266156
21TESK11.72231345
22STK381.70743625
23PAK31.58548278
24WNK31.50583380
25PTK61.46332504
26MAP3K61.46004464
27ERBB41.45597646
28TIE11.44763934
29FER1.38165379
30PIM21.37429033
31CDK121.34559819
32SIK11.33357139
33LATS11.31446215
34KSR21.30857518
35MOS1.28250864
36ERN11.26363341
37DDR21.25316778
38PINK11.24674724
39PRKG21.20142238
40NTRK11.17724944
41DMPK1.15788676
42PTK21.14982712
43PAK61.14782076
44MYLK1.14598665
45TAOK21.13211710
46ICK1.12571150
47FGFR41.12036490
48MAP2K31.10914730
49ZAP701.08972933
50ABL21.08835622
51STK38L0.98460239
52PRPF4B0.98019209
53EPHA40.97706698
54TRPM70.94569085
55PRKD10.94564084
56EPHB10.94280731
57MST1R0.92967749
58CAMKK10.91253135
59LIMK10.91046345
60RPS6KA20.90858592
61EEF2K0.89944959
62PAK40.88643070
63BMX0.88513184
64NEK90.84032303
65TAOK10.82965279
66MET0.80644350
67TYRO30.79875567
68MAPKAPK30.78515677
69PTK2B0.78496721
70TBK10.77782221
71PDPK10.77350035
72MAP3K110.76046240
73PRKAA10.75153374
74MAP2K10.74922869
75ARAF0.74347014
76ROCK10.73435372
77DAPK20.73130487
78MAPK110.71379736
79MTOR0.70841281
80RET0.70479344
81PRKCH0.68593060
82MAP3K130.68433920
83MAP3K20.67634576
84EPHB20.67112638
85CDC42BPA0.66996233
86MAP3K70.66754103
87MAPK150.66398755
88ALK0.64462087
89LRRK20.62971996
90FGFR10.62399412
91SMG10.61955012
92MARK10.61318174
93OXSR10.61312293
94FGFR20.59722050
95CAMK1G0.58672546
96PDGFRB0.57590899
97MUSK0.54875617
98DYRK1B0.54130674
99ILK0.54084247
100CAMK1D0.53732122
101MAP3K10.51910902
102PRKD20.50371287
103MAP3K140.49671410
104FLT30.49054516
105DAPK30.48583128
106MAPK120.48230096
107RPS6KC10.47841904
108RPS6KL10.47841904
109MAP3K30.47240111
110CAMK2D0.47202712
111GRK70.47119374
112INSRR0.47049208
113SGK30.44929220
114PRKAA20.44926359
115PAK20.44677246
116GSK3A0.42173990
117MAPK70.42117055
118MAP3K80.41776180
119PDK10.41645163
120KDR0.41163343
121ADRBK20.40580347
122WNK10.40578490
123CAMK2G0.40359674
124MAP2K40.39309004
125MARK20.38661443
126CAMK2B0.36785830
127STK390.36192555
128STK110.36077537
129MINK10.35814132
130PRKACG0.35324322
131PRKCI0.35248511
132RPS6KA60.34999271
133PRKCE0.34647093
134PRKCZ0.34548925
135TGFBR20.34472835
136MAP2K60.34122360
137MAP2K20.33114611
138STK100.32303405
139ROCK20.31879302
140MELK0.31814238
141CLK10.31794909
142ADRBK10.30729883
143NTRK30.29040772
144SIK20.27936819

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.54447959
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.26536654
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.14184834
4Other glycan degradation_Homo sapiens_hsa005113.10080725
5Nitrogen metabolism_Homo sapiens_hsa009102.79198863
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.61956750
7Fatty acid degradation_Homo sapiens_hsa000712.57930469
8Propanoate metabolism_Homo sapiens_hsa006402.31795152
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.24191931
10Lysosome_Homo sapiens_hsa041422.21594371
11Fatty acid metabolism_Homo sapiens_hsa012122.19914806
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.09238288
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.04248448
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.99492399
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.89642581
16Carbon metabolism_Homo sapiens_hsa012001.81699757
17Butanoate metabolism_Homo sapiens_hsa006501.77830835
18Dilated cardiomyopathy_Homo sapiens_hsa054141.77084601
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69388395
20Arginine biosynthesis_Homo sapiens_hsa002201.68399004
21Fatty acid biosynthesis_Homo sapiens_hsa000611.63802059
22PPAR signaling pathway_Homo sapiens_hsa033201.62713360
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.55164907
24Bile secretion_Homo sapiens_hsa049761.46857686
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.45472488
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.44314437
27Pyruvate metabolism_Homo sapiens_hsa006201.41311245
28Cardiac muscle contraction_Homo sapiens_hsa042601.33405967
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.32790432
30Biosynthesis of amino acids_Homo sapiens_hsa012301.30571911
31Sphingolipid metabolism_Homo sapiens_hsa006001.29448552
32Small cell lung cancer_Homo sapiens_hsa052221.27185366
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25505509
34TNF signaling pathway_Homo sapiens_hsa046681.24660691
35Chronic myeloid leukemia_Homo sapiens_hsa052201.19517257
36Protein digestion and absorption_Homo sapiens_hsa049741.17102448
37Fat digestion and absorption_Homo sapiens_hsa049751.16405532
38Tryptophan metabolism_Homo sapiens_hsa003801.11709282
39Pancreatic secretion_Homo sapiens_hsa049721.11396725
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08895394
41Pertussis_Homo sapiens_hsa051331.08277559
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08193508
43Vitamin B6 metabolism_Homo sapiens_hsa007501.06894893
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.03281731
45Salmonella infection_Homo sapiens_hsa051321.01085832
46ECM-receptor interaction_Homo sapiens_hsa045120.98669263
47Glycerolipid metabolism_Homo sapiens_hsa005610.97560607
48Gastric acid secretion_Homo sapiens_hsa049710.96778890
49Glucagon signaling pathway_Homo sapiens_hsa049220.96487313
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95356420
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94690236
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94363967
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.92819758
54Focal adhesion_Homo sapiens_hsa045100.91839207
55ABC transporters_Homo sapiens_hsa020100.91420845
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91059819
57Osteoclast differentiation_Homo sapiens_hsa043800.90465675
58Tight junction_Homo sapiens_hsa045300.90410783
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90355069
60Insulin resistance_Homo sapiens_hsa049310.89918106
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89086912
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88684004
63Insulin secretion_Homo sapiens_hsa049110.87510452
64Starch and sucrose metabolism_Homo sapiens_hsa005000.86298563
65Malaria_Homo sapiens_hsa051440.85394095
66Toxoplasmosis_Homo sapiens_hsa051450.85278330
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.82926206
68Dorso-ventral axis formation_Homo sapiens_hsa043200.80425572
69Pancreatic cancer_Homo sapiens_hsa052120.80101132
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80094049
71Lysine degradation_Homo sapiens_hsa003100.79093638
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78068900
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.78009936
74Notch signaling pathway_Homo sapiens_hsa043300.77123397
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76962889
76beta-Alanine metabolism_Homo sapiens_hsa004100.76271498
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75652517
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75068404
79Arginine and proline metabolism_Homo sapiens_hsa003300.73666829
80Peroxisome_Homo sapiens_hsa041460.72345075
81Platelet activation_Homo sapiens_hsa046110.71958677
82Adherens junction_Homo sapiens_hsa045200.71640598
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.71582428
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71204605
85Endocytosis_Homo sapiens_hsa041440.71170526
86MicroRNAs in cancer_Homo sapiens_hsa052060.70918900
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.70356372
88Insulin signaling pathway_Homo sapiens_hsa049100.70209035
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70078136
90Fructose and mannose metabolism_Homo sapiens_hsa000510.69021649
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68450357
92AMPK signaling pathway_Homo sapiens_hsa041520.68411821
93Vibrio cholerae infection_Homo sapiens_hsa051100.66714226
94ErbB signaling pathway_Homo sapiens_hsa040120.66659703
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66081243
96Sulfur relay system_Homo sapiens_hsa041220.65375770
97Acute myeloid leukemia_Homo sapiens_hsa052210.65330103
98Vitamin digestion and absorption_Homo sapiens_hsa049770.64695296
99Shigellosis_Homo sapiens_hsa051310.64515497
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.64475455
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.64247778
102Glioma_Homo sapiens_hsa052140.64135096
103Bladder cancer_Homo sapiens_hsa052190.64066141
104Amoebiasis_Homo sapiens_hsa051460.62073813
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62012641
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61892929
107Salivary secretion_Homo sapiens_hsa049700.60957999
108Apoptosis_Homo sapiens_hsa042100.60900132
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.60520725
110Ovarian steroidogenesis_Homo sapiens_hsa049130.60188315
111Histidine metabolism_Homo sapiens_hsa003400.59725478
112Type II diabetes mellitus_Homo sapiens_hsa049300.59351332
113Phagosome_Homo sapiens_hsa041450.58502542
114Estrogen signaling pathway_Homo sapiens_hsa049150.57485816
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57169818
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56502799
117Thyroid hormone synthesis_Homo sapiens_hsa049180.54635866
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53878640
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52013293
120Proteoglycans in cancer_Homo sapiens_hsa052050.51467902
121N-Glycan biosynthesis_Homo sapiens_hsa005100.51216948
122Gap junction_Homo sapiens_hsa045400.51200731
123mTOR signaling pathway_Homo sapiens_hsa041500.49720321
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49557361
125Staphylococcus aureus infection_Homo sapiens_hsa051500.48937700
126Mineral absorption_Homo sapiens_hsa049780.48074773
127Sulfur metabolism_Homo sapiens_hsa009200.47538904
128Hepatitis C_Homo sapiens_hsa051600.47338308
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.47046500
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46756651
131Renin-angiotensin system_Homo sapiens_hsa046140.46567771
132Prion diseases_Homo sapiens_hsa050200.45650260
133Hippo signaling pathway_Homo sapiens_hsa043900.42918283
134Prolactin signaling pathway_Homo sapiens_hsa049170.41899274
135Tuberculosis_Homo sapiens_hsa051520.41856622
136Galactose metabolism_Homo sapiens_hsa000520.41483233
137GnRH signaling pathway_Homo sapiens_hsa049120.41288813
138Renal cell carcinoma_Homo sapiens_hsa052110.40937497
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40826082
140Renin secretion_Homo sapiens_hsa049240.40289411
141Circadian rhythm_Homo sapiens_hsa047100.40075551
142Pathways in cancer_Homo sapiens_hsa052000.39363151
143Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39079229
144Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38746906
145NF-kappa B signaling pathway_Homo sapiens_hsa040640.38464334
146Rap1 signaling pathway_Homo sapiens_hsa040150.38061061
147Pentose phosphate pathway_Homo sapiens_hsa000300.37852191
148Cyanoamino acid metabolism_Homo sapiens_hsa004600.37770433
149cAMP signaling pathway_Homo sapiens_hsa040240.37182726
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.36933887
151Complement and coagulation cascades_Homo sapiens_hsa046100.36191937
152Synaptic vesicle cycle_Homo sapiens_hsa047210.35316077
153Selenocompound metabolism_Homo sapiens_hsa004500.34981609
154VEGF signaling pathway_Homo sapiens_hsa043700.34882962
155Phenylalanine metabolism_Homo sapiens_hsa003600.34865850
156Circadian entrainment_Homo sapiens_hsa047130.34063064

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