KIN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)9.10562596
2polyketide metabolic process (GO:0030638)9.10562596
3doxorubicin metabolic process (GO:0044598)9.10562596
4negative regulation of epidermis development (GO:0045683)6.25536851
5heterochromatin organization (GO:0070828)5.91866983
6protein localization to kinetochore (GO:0034501)5.80829474
7regulation of nuclear cell cycle DNA replication (GO:0033262)5.70292831
8aminoglycoside antibiotic metabolic process (GO:0030647)5.67229472
9behavioral response to nicotine (GO:0035095)5.54239290
10maintenance of protein location in nucleus (GO:0051457)5.53905951
11negative regulation of epidermal cell differentiation (GO:0045605)5.50393605
12somite rostral/caudal axis specification (GO:0032525)5.25103221
13negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.03699394
14regulation of mammary gland epithelial cell proliferation (GO:0033599)4.93502070
15negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.92657081
16rRNA transcription (GO:0009303)4.77978195
17rRNA methylation (GO:0031167)4.75188570
18DNA replication checkpoint (GO:0000076)4.68907819
19negative regulation of cell cycle G2/M phase transition (GO:1902750)4.60248298
20rRNA modification (GO:0000154)4.58670151
21regulation of response to osmotic stress (GO:0047484)4.57954982
22DNA damage response, detection of DNA damage (GO:0042769)4.47776432
23regulation of telomere maintenance via telomerase (GO:0032210)4.47766832
24mitotic sister chromatid segregation (GO:0000070)4.41990970
25muscle organ morphogenesis (GO:0048644)4.37327210
26protein localization to chromosome, centromeric region (GO:0071459)4.35388326
27L-fucose catabolic process (GO:0042355)4.30144889
28fucose catabolic process (GO:0019317)4.30144889
29L-fucose metabolic process (GO:0042354)4.30144889
30regulation of translation in response to stress (GO:0043555)4.29896765
31ribosomal small subunit biogenesis (GO:0042274)4.28607342
32notochord development (GO:0030903)4.26510630
33negative regulation of telomerase activity (GO:0051974)4.22329176
34phenol-containing compound catabolic process (GO:0019336)4.22297349
35negative regulation of telomere maintenance (GO:0032205)4.18625545
36regulation of cilium movement (GO:0003352)4.11875992
37regulation of MHC class I biosynthetic process (GO:0045343)4.05610194
38histone H4-K12 acetylation (GO:0043983)4.03574079
39cullin deneddylation (GO:0010388)4.01556326
40DNA replication-dependent nucleosome assembly (GO:0006335)4.01540350
41DNA replication-dependent nucleosome organization (GO:0034723)4.01540350
42quinone metabolic process (GO:1901661)3.94677436
43positive regulation of DNA-dependent DNA replication (GO:2000105)3.92256775
44cell fate commitment involved in formation of primary germ layer (GO:0060795)3.83815012
45indolalkylamine metabolic process (GO:0006586)3.80620676
46cytidine metabolic process (GO:0046087)3.78330480
47cytidine catabolic process (GO:0006216)3.78330480
48cytidine deamination (GO:0009972)3.78330480
49water-soluble vitamin biosynthetic process (GO:0042364)3.75172579
50indole-containing compound catabolic process (GO:0042436)3.72812173
51indolalkylamine catabolic process (GO:0046218)3.72812173
52tryptophan catabolic process (GO:0006569)3.72812173
53interferon-gamma production (GO:0032609)3.72082073
54pseudouridine synthesis (GO:0001522)3.65139120
55regulation of apoptotic process involved in morphogenesis (GO:1902337)3.64275194
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.64168819
57mitochondrial respiratory chain complex I assembly (GO:0032981)3.64168819
58NADH dehydrogenase complex assembly (GO:0010257)3.64168819
59protein complex biogenesis (GO:0070271)3.63996486
60sister chromatid segregation (GO:0000819)3.63993074
61histone H4-K8 acetylation (GO:0043982)3.59131222
62histone H4-K5 acetylation (GO:0043981)3.59131222
63protein deneddylation (GO:0000338)3.56918604
64kynurenine metabolic process (GO:0070189)3.56128871
65detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.51904531
66nucleoside transmembrane transport (GO:1901642)3.50259939
67mitochondrial respiratory chain complex assembly (GO:0033108)3.49054820
68DNA double-strand break processing (GO:0000729)3.47380397
69ribonucleoprotein complex biogenesis (GO:0022613)3.46778476
70DNA deamination (GO:0045006)3.41032142
71ribosome biogenesis (GO:0042254)3.37272128
72primitive streak formation (GO:0090009)3.35934347
73regulation of telomere maintenance (GO:0032204)3.34885776
74mitotic G2/M transition checkpoint (GO:0044818)3.34295650
75tryptophan metabolic process (GO:0006568)3.32361698
76chromatin assembly (GO:0031497)3.30721905
77sulfation (GO:0051923)3.30393477
78response to pheromone (GO:0019236)3.28969592
79platelet dense granule organization (GO:0060155)3.26733243
80epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.25661219
81neural tube formation (GO:0001841)3.22050292
82nuclear pore complex assembly (GO:0051292)3.18509213
83DNA methylation involved in gamete generation (GO:0043046)3.17494094
84pyrimidine nucleobase catabolic process (GO:0006208)3.16340362
85negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.12620939
86maturation of 5.8S rRNA (GO:0000460)3.11840889
87respiratory chain complex IV assembly (GO:0008535)3.11170315
88piRNA metabolic process (GO:0034587)3.10365184
89nuclear pore organization (GO:0006999)3.09057792
90detection of light stimulus involved in visual perception (GO:0050908)3.06392978
91detection of light stimulus involved in sensory perception (GO:0050962)3.06392978
92cellular component biogenesis (GO:0044085)3.00902984
93coenzyme catabolic process (GO:0009109)2.98832357
94chaperone-mediated protein transport (GO:0072321)2.98547300
95formation of translation preinitiation complex (GO:0001731)2.98143009
96intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.97050224
97negative regulation of transcription regulatory region DNA binding (GO:2000678)2.96839634
98regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.95974664
99nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.95664204
100neuronal action potential (GO:0019228)2.95391760
101regulation of DNA-dependent DNA replication (GO:0090329)2.95292441
102DNA replication initiation (GO:0006270)2.94623844
103mitochondrial DNA replication (GO:0006264)2.94609140
104negative regulation of DNA-dependent DNA replication (GO:2000104)2.94109852
105nonmotile primary cilium assembly (GO:0035058)2.93115455
106cytochrome complex assembly (GO:0017004)2.92625157
107mitotic chromosome condensation (GO:0007076)2.92203733
108indole-containing compound metabolic process (GO:0042430)2.91893114
109response to dietary excess (GO:0002021)2.90596580
110positive regulation of histone H3-K4 methylation (GO:0051571)2.90475259
111RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.89439006
112tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.89439006
113regulation of double-strand break repair (GO:2000779)2.87966233
114epithelial cilium movement (GO:0003351)2.87944847
115exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87606655
116transcription from mitochondrial promoter (GO:0006390)2.87119634
117positive regulation of defense response to virus by host (GO:0002230)2.85356182
118establishment of protein localization to mitochondrial membrane (GO:0090151)2.85249513
119kidney morphogenesis (GO:0060993)2.84571100
120branching involved in mammary gland duct morphogenesis (GO:0060444)2.84206473
121ribosomal large subunit biogenesis (GO:0042273)2.83486481
122negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.81395304
123RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.79982469
124recombinational repair (GO:0000725)2.79737261
125cilium morphogenesis (GO:0060271)2.79022832
126positive regulation of prostaglandin secretion (GO:0032308)2.78543147
127double-strand break repair via homologous recombination (GO:0000724)2.78426043
128nucleobase catabolic process (GO:0046113)2.78042633
129behavioral response to ethanol (GO:0048149)2.77549802
130apoptotic DNA fragmentation (GO:0006309)2.75055349
131omega-hydroxylase P450 pathway (GO:0097267)2.73462284
132somatic diversification of immune receptors via somatic mutation (GO:0002566)2.73461419
133somatic hypermutation of immunoglobulin genes (GO:0016446)2.73461419
134presynaptic membrane assembly (GO:0097105)2.72557294
135maintenance of protein localization in organelle (GO:0072595)2.71471409
136amine catabolic process (GO:0009310)2.69959825
137cellular biogenic amine catabolic process (GO:0042402)2.69959825
138negative regulation of translation, ncRNA-mediated (GO:0040033)2.68985306
139regulation of translation, ncRNA-mediated (GO:0045974)2.68985306
140negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.68985306
141regulation of telomerase activity (GO:0051972)2.68210732
142attachment of spindle microtubules to kinetochore (GO:0008608)2.65212211
143regulation of mesoderm development (GO:2000380)2.64543846
144dopamine transport (GO:0015872)2.64465835
145rRNA catabolic process (GO:0016075)2.63913114
146gamma-aminobutyric acid transport (GO:0015812)2.63565094
147cell proliferation in forebrain (GO:0021846)2.62970875
148ATP synthesis coupled proton transport (GO:0015986)2.62392499
149energy coupled proton transport, down electrochemical gradient (GO:0015985)2.62392499
150positive regulation of fatty acid transport (GO:2000193)2.61774160
151regulation of double-strand break repair via homologous recombination (GO:0010569)2.60627251
152axoneme assembly (GO:0035082)2.60236011
153protein neddylation (GO:0045116)2.59929026
154cofactor transport (GO:0051181)2.59901892
155DNA unwinding involved in DNA replication (GO:0006268)2.59693598
156maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.59540258
157hormone catabolic process (GO:0042447)2.59507072
158protein polyglutamylation (GO:0018095)2.58858329
159photoreceptor cell maintenance (GO:0045494)2.58591001
160negative regulation of signal transduction by p53 class mediator (GO:1901797)2.58507246
161proteasome assembly (GO:0043248)2.58331558
162protein-cofactor linkage (GO:0018065)2.56959847
163primary amino compound metabolic process (GO:1901160)2.55452697
164transcription from RNA polymerase I promoter (GO:0006360)2.55002430
165preassembly of GPI anchor in ER membrane (GO:0016254)2.54815576
166regulation of hexokinase activity (GO:1903299)2.54356880
167regulation of glucokinase activity (GO:0033131)2.54356880
168positive regulation of developmental pigmentation (GO:0048087)2.54343041
169histone H4-K16 acetylation (GO:0043984)2.53617211
170serotonin metabolic process (GO:0042428)2.51903911
171cilium organization (GO:0044782)2.51630535
172regulation of meiosis I (GO:0060631)2.51555933
173rRNA processing (GO:0006364)2.51088233
174GDP-mannose metabolic process (GO:0019673)2.50017791
175transmission of nerve impulse (GO:0019226)2.48083002
176transcription elongation from RNA polymerase III promoter (GO:0006385)2.48002465
177termination of RNA polymerase III transcription (GO:0006386)2.48002465
178single strand break repair (GO:0000012)2.47872632
179replication fork processing (GO:0031297)2.47648883
180nucleoside transport (GO:0015858)2.47622342
181mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.46460270
182spinal cord motor neuron differentiation (GO:0021522)2.46233667
183protein K6-linked ubiquitination (GO:0085020)2.44695279
184presynaptic membrane organization (GO:0097090)2.44328678
185regulation of gene silencing by RNA (GO:0060966)2.44087266
186regulation of posttranscriptional gene silencing (GO:0060147)2.44087266
187regulation of gene silencing by miRNA (GO:0060964)2.44087266
188mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.43625020
189centriole replication (GO:0007099)2.42970432
190reciprocal DNA recombination (GO:0035825)2.42768768
191reciprocal meiotic recombination (GO:0007131)2.42768768
192cilium assembly (GO:0042384)2.42571595
193photoreceptor cell development (GO:0042461)2.41978051
194negative regulation of appetite (GO:0032099)2.41637891
195negative regulation of response to food (GO:0032096)2.41637891

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.12810108
2E2F7_22180533_ChIP-Seq_HELA_Human5.89103674
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.09757495
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.09757495
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.09757495
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human5.01680636
7ZNF274_21170338_ChIP-Seq_K562_Hela4.12114649
8EZH2_22144423_ChIP-Seq_EOC_Human3.73087923
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.49181606
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.28365362
11TP63_19390658_ChIP-ChIP_HaCaT_Human3.22160941
12VDR_22108803_ChIP-Seq_LS180_Human3.20461945
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.03659951
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.85308615
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.78501260
16GBX2_23144817_ChIP-Seq_PC3_Human2.77457195
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.65617068
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.64160167
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.60333341
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.56670981
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.55114526
22IRF1_19129219_ChIP-ChIP_H3396_Human2.53785070
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53632760
24NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.51535929
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.44402038
26SALL1_21062744_ChIP-ChIP_HESCs_Human2.36396381
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.34335776
28IGF1R_20145208_ChIP-Seq_DFB_Human2.34129171
29EWS_26573619_Chip-Seq_HEK293_Human2.32142562
30FUS_26573619_Chip-Seq_HEK293_Human2.28557759
31* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25244818
32MYC_19030024_ChIP-ChIP_MESCs_Mouse2.24648349
33SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.17905154
34FLI1_27457419_Chip-Seq_LIVER_Mouse2.17362439
35ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13908459
36TAF15_26573619_Chip-Seq_HEK293_Human2.13316010
37NOTCH1_21737748_ChIP-Seq_TLL_Human2.11720479
38CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11558610
39P300_19829295_ChIP-Seq_ESCs_Human2.10350901
40TCF3_18692474_ChIP-Seq_MESCs_Mouse2.09590481
41MYC_19079543_ChIP-ChIP_MESCs_Mouse2.05400408
42* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.03173342
43CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02095543
44ETS1_20019798_ChIP-Seq_JURKAT_Human2.02067106
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.99982281
46TCF3_18692474_ChIP-Seq_MEFs_Mouse1.99557830
47* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.99042963
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97813771
49SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.90213164
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.90177475
51NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.89637184
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.88873017
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.84408888
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83149178
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.72759525
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72605602
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.71539227
58FOXP3_21729870_ChIP-Seq_TREG_Human1.70010871
59ER_23166858_ChIP-Seq_MCF-7_Human1.69732562
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66954790
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65762642
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64868612
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.64209459
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.63532414
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63057905
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62191189
67MYC_18940864_ChIP-ChIP_HL60_Human1.58125988
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57303107
69VDR_23849224_ChIP-Seq_CD4+_Human1.56971684
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56659258
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.55983322
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55818827
73BCAT_22108803_ChIP-Seq_LS180_Human1.54251167
74* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52588117
75HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49643978
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.48609596
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.48349856
78STAT3_23295773_ChIP-Seq_U87_Human1.45778515
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43698560
80XRN2_22483619_ChIP-Seq_HELA_Human1.43549267
81TP53_22573176_ChIP-Seq_HFKS_Human1.42546163
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42108411
83CBP_20019798_ChIP-Seq_JUKART_Human1.41558403
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41558403
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40840367
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39169681
87TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38840544
88TTF2_22483619_ChIP-Seq_HELA_Human1.38280589
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38025001
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.37327859
91BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37204535
92NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36818899
93SMAD4_21799915_ChIP-Seq_A2780_Human1.35932472
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35752716
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35752716
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35281142
97ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33676988
98STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32987672
99AR_25329375_ChIP-Seq_VCAP_Human1.31773949
100ELK1_19687146_ChIP-ChIP_HELA_Human1.31612015
101SOX2_19829295_ChIP-Seq_ESCs_Human1.31403231
102NANOG_19829295_ChIP-Seq_ESCs_Human1.31403231
103KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30317000
104PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30019341
105TCF4_23295773_ChIP-Seq_U87_Human1.29780136
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.26741750
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26641499
108SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26297247
109NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24811488
110PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24519743
111REST_21632747_ChIP-Seq_MESCs_Mouse1.24474474
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24400500
113NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.24046510
114EZH2_27294783_Chip-Seq_NPCs_Mouse1.23105105
115STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22714261
116NFE2_27457419_Chip-Seq_LIVER_Mouse1.21987842
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20990117
118RUNX2_22187159_ChIP-Seq_PCA_Human1.20450415
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20193195
120TCF4_22108803_ChIP-Seq_LS180_Human1.18522802
121POU5F1_16518401_ChIP-PET_MESCs_Mouse1.17528485
122E2F1_17053090_ChIP-ChIP_MCF-7_Human1.17182250
123FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16860576
124FOXA1_25329375_ChIP-Seq_VCAP_Human1.16860576
125DCP1A_22483619_ChIP-Seq_HELA_Human1.15407367
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14614291
127HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14588533
128ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13010168
129NANOG_16153702_ChIP-ChIP_HESCs_Human1.12981028
130POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.12811626
131FLI1_21867929_ChIP-Seq_TH2_Mouse1.12223703
132SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12174473
133KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11123849
134ELK1_22589737_ChIP-Seq_MCF10A_Human1.10413268
135SMAD4_21741376_ChIP-Seq_EPCs_Human1.07928926
136THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07706533
137YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07203033
138KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06814338
139KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06664622
140CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06377155
141TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.06222590
142PRDM14_20953172_ChIP-Seq_ESCs_Human1.05483467
143AR_21572438_ChIP-Seq_LNCaP_Human1.05291067
144GATA3_21878914_ChIP-Seq_MCF-7_Human1.04909463
145CRX_20693478_ChIP-Seq_RETINA_Mouse1.04498098
146ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04475261
147SRF_21415370_ChIP-Seq_HL-1_Mouse1.03829040
148NCOR_22424771_ChIP-Seq_293T_Human1.03155919
149NANOG_18692474_ChIP-Seq_MEFs_Mouse1.02861138
150RNF2_27304074_Chip-Seq_NSC_Mouse1.02445919
151TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01889349
152EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00660961
153* GABP_19822575_ChIP-Seq_HepG2_Human1.00340355
154NANOG_18555785_Chip-Seq_ESCs_Mouse1.00325983
155* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00279288
156TP53_16413492_ChIP-PET_HCT116_Human1.00224386
157FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99689122
158ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99131945
159AR_20517297_ChIP-Seq_VCAP_Human0.98536849
160P53_22387025_ChIP-Seq_ESCs_Mouse0.97163206
161KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97108459
162SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97047507
163AR_21909140_ChIP-Seq_LNCAP_Human0.96661546
164* HOXB7_26014856_ChIP-Seq_BT474_Human0.96041032
165EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95703687
166OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95036291
167NANOG_18692474_ChIP-Seq_MESCs_Mouse0.94410175
168PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94360158
169BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94324131
170* JUN_21703547_ChIP-Seq_K562_Human0.93468215
171HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92640345
172SOX2_16153702_ChIP-ChIP_HESCs_Human0.92082491
173CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90806439
174* KDM5A_27292631_Chip-Seq_BREAST_Human0.90106662
175* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88930051
176SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.88045173
177SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87817002
178SOX2_18692474_ChIP-Seq_MESCs_Mouse0.84023259
179MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.83427941
180BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81524360
181* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81098258
182NANOG_21062744_ChIP-ChIP_HESCs_Human0.79374884
183CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.78985177
184ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.78363394
185PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.77824315
186CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.76782333
187SCL_19346495_ChIP-Seq_HPC-7_Human0.76717038

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.13310763
2MP0003011_delayed_dark_adaptation4.54998103
3MP0008057_abnormal_DNA_replication4.53288004
4MP0003890_abnormal_embryonic-extraembry3.52125760
5MP0000569_abnormal_digit_pigmentation3.38551973
6MP0004264_abnormal_extraembryonic_tissu3.35026447
7MP0005075_abnormal_melanosome_morpholog3.27965558
8MP0004957_abnormal_blastocyst_morpholog3.16695543
9MP0008877_abnormal_DNA_methylation2.92775274
10MP0002254_reproductive_system_inflammat2.89872206
11MP0003195_calcinosis2.82071834
12MP0005499_abnormal_olfactory_system2.78322958
13MP0005394_taste/olfaction_phenotype2.78322958
14MP0003880_abnormal_central_pattern2.75708788
15MP0003122_maternal_imprinting2.69371136
16MP0002332_abnormal_exercise_endurance2.37091182
17MP0003646_muscle_fatigue2.35031622
18MP0002102_abnormal_ear_morphology2.25313728
19MP0003121_genomic_imprinting2.24946741
20MP0005551_abnormal_eye_electrophysiolog2.24732274
21MP0001968_abnormal_touch/_nociception2.19472562
22MP0003938_abnormal_ear_development2.19330027
23MP0006072_abnormal_retinal_apoptosis2.11301137
24MP0003077_abnormal_cell_cycle2.10471305
25MP0008872_abnormal_physiological_respon2.05606510
26MP0010094_abnormal_chromosome_stability1.98697486
27MP0002277_abnormal_respiratory_mucosa1.98038545
28MP0002837_dystrophic_cardiac_calcinosis1.94701392
29MP0006035_abnormal_mitochondrial_morpho1.90073097
30MP0009046_muscle_twitch1.87454409
31MP0002736_abnormal_nociception_after1.85313158
32MP0000631_abnormal_neuroendocrine_gland1.83131060
33MP0004381_abnormal_hair_follicle1.79718498
34MP0004142_abnormal_muscle_tone1.79229472
35MP0003111_abnormal_nucleus_morphology1.77312736
36MP0003693_abnormal_embryo_hatching1.76203712
37MP0001485_abnormal_pinna_reflex1.76045201
38MP0005645_abnormal_hypothalamus_physiol1.75025813
39MP0000678_abnormal_parathyroid_gland1.74855162
40MP0005257_abnormal_intraocular_pressure1.71255065
41MP0000049_abnormal_middle_ear1.69703912
42MP0002638_abnormal_pupillary_reflex1.66992053
43MP0001672_abnormal_embryogenesis/_devel1.66428597
44MP0005380_embryogenesis_phenotype1.66428597
45MP0009745_abnormal_behavioral_response1.64102754
46MP0001293_anophthalmia1.63655202
47MP0002396_abnormal_hematopoietic_system1.63508590
48MP0008932_abnormal_embryonic_tissue1.62735159
49MP0006276_abnormal_autonomic_nervous1.62660947
50MP0005084_abnormal_gallbladder_morpholo1.62182128
51MP0008058_abnormal_DNA_repair1.61805527
52MP0002272_abnormal_nervous_system1.61714207
53MP0002127_abnormal_cardiovascular_syste1.59574816
54MP0001986_abnormal_taste_sensitivity1.58144229
55MP0000427_abnormal_hair_cycle1.57172192
56MP0002088_abnormal_embryonic_growth/wei1.52980915
57MP0005174_abnormal_tail_pigmentation1.52912877
58MP0003984_embryonic_growth_retardation1.50888336
59MP0000762_abnormal_tongue_morphology1.49065303
60MP0000350_abnormal_cell_proliferation1.48219403
61MP0001486_abnormal_startle_reflex1.46965619
62MP0002876_abnormal_thyroid_physiology1.46195942
63MP0000372_irregular_coat_pigmentation1.45027627
64MP0004147_increased_porphyrin_level1.42133224
65MP0002160_abnormal_reproductive_system1.40973002
66MP0001529_abnormal_vocalization1.40848972
67MP0008789_abnormal_olfactory_epithelium1.38911471
68MP0000383_abnormal_hair_follicle1.37707671
69MP0003315_abnormal_perineum_morphology1.36286415
70MP0006082_CNS_inflammation1.36185523
71MP0008007_abnormal_cellular_replicative1.34429484
72MP0002928_abnormal_bile_duct1.34000205
73MP0005646_abnormal_pituitary_gland1.33408369
74MP0003123_paternal_imprinting1.32536433
75MP0001984_abnormal_olfaction1.31723159
76MP0002132_abnormal_respiratory_system1.29822429
77MP0002092_abnormal_eye_morphology1.28317455
78MP0005266_abnormal_metabolism1.27700339
79MP0004742_abnormal_vestibular_system1.25851285
80MP0005389_reproductive_system_phenotype1.24442546
81MP0001730_embryonic_growth_arrest1.22963079
82MP0002735_abnormal_chemical_nociception1.22153384
83MP0008875_abnormal_xenobiotic_pharmacok1.21356061
84MP0001501_abnormal_sleep_pattern1.20522340
85MP0002932_abnormal_joint_morphology1.20442043
86MP0002085_abnormal_embryonic_tissue1.17625665
87MP0002557_abnormal_social/conspecific_i1.16251047
88MP0010030_abnormal_orbit_morphology1.15939852
89MP0002653_abnormal_ependyma_morphology1.15646387
90MP0005195_abnormal_posterior_eye1.14311881
91MP0002067_abnormal_sensory_capabilities1.14241888
92MP0002064_seizures1.13911735
93MP0002095_abnormal_skin_pigmentation1.12662214
94MP0003136_yellow_coat_color1.11870718
95MP0002138_abnormal_hepatobiliary_system1.11838678
96MP0003786_premature_aging1.11138004
97MP0004885_abnormal_endolymph1.10949128
98MP0005386_behavior/neurological_phenoty1.10509520
99MP0004924_abnormal_behavior1.10509520
100MP0002572_abnormal_emotion/affect_behav1.10115432
101MP0000778_abnormal_nervous_system1.09777534
102MP0003937_abnormal_limbs/digits/tail_de1.09352475
103MP0000566_synostosis1.08742765
104MP0000313_abnormal_cell_death1.07876743
105MP0002234_abnormal_pharynx_morphology1.07725523
106MP0002938_white_spotting1.05903566
107MP0001286_abnormal_eye_development1.04681890
108MP0000432_abnormal_head_morphology1.04640533
109MP0000490_abnormal_crypts_of1.03127880
110MP0004215_abnormal_myocardial_fiber1.02334826
111MP0008995_early_reproductive_senescence1.00961149
112MP0002086_abnormal_extraembryonic_tissu0.99856508
113MP0001970_abnormal_pain_threshold0.99095263
114MP0001919_abnormal_reproductive_system0.99039385
115MP0002114_abnormal_axial_skeleton0.98571897
116MP0005391_vision/eye_phenotype0.97505175
117MP0003183_abnormal_peptide_metabolism0.96243747
118MP0002752_abnormal_somatic_nervous0.95862124
119MP0002233_abnormal_nose_morphology0.94628328
120MP0004858_abnormal_nervous_system0.94463575
121MP0004145_abnormal_muscle_electrophysio0.94257887
122MP0001697_abnormal_embryo_size0.93697221
123MP0002733_abnormal_thermal_nociception0.93398859
124MP0005410_abnormal_fertilization0.93392023
125MP0003119_abnormal_digestive_system0.93162829
126MP0002210_abnormal_sex_determination0.92722250
127MP0003252_abnormal_bile_duct0.92232413
128MP0002751_abnormal_autonomic_nervous0.91212151
129MP0003755_abnormal_palate_morphology0.89518664
130MP0003698_abnormal_male_reproductive0.89111687
131MP0002098_abnormal_vibrissa_morphology0.89079938
132MP0003283_abnormal_digestive_organ0.87554432
133MP0002084_abnormal_developmental_patter0.87133153
134MP0003137_abnormal_impulse_conducting0.86967379
135MP0002734_abnormal_mechanical_nocicepti0.86888640
136MP0003787_abnormal_imprinting0.86229583
137MP0003635_abnormal_synaptic_transmissio0.85932089
138MP0009764_decreased_sensitivity_to0.85446934
139MP0000026_abnormal_inner_ear0.85031701
140MP0001929_abnormal_gametogenesis0.84091375
141MP0001905_abnormal_dopamine_level0.81788444
142MP0001324_abnormal_eye_pigmentation0.81198045
143MP0004197_abnormal_fetal_growth/weight/0.80094391
144MP0000653_abnormal_sex_gland0.79971285
145MP0003935_abnormal_craniofacial_develop0.78275775
146MP0002063_abnormal_learning/memory/cond0.78273070
147MP0005248_abnormal_Harderian_gland0.76577782
148MP0000428_abnormal_craniofacial_morphol0.76410958
149MP0005377_hearing/vestibular/ear_phenot0.76140614
150MP0003878_abnormal_ear_physiology0.76140614
151MP0003567_abnormal_fetal_cardiomyocyte0.76129426
152MP0003186_abnormal_redox_activity0.75085793
153MP0002080_prenatal_lethality0.74729654
154MP0002163_abnormal_gland_morphology0.73998471
155MP0001188_hyperpigmentation0.73540258
156MP0004133_heterotaxia0.71259694
157MP0002249_abnormal_larynx_morphology0.70553129
158MP0010352_gastrointestinal_tract_polyps0.68630968
159MP0002116_abnormal_craniofacial_bone0.68591805
160MP0002970_abnormal_white_adipose0.67167008
161MP0005253_abnormal_eye_physiology0.66855611
162MP0005508_abnormal_skeleton_morphology0.66848525
163MP0000750_abnormal_muscle_regeneration0.66307948
164MP0001849_ear_inflammation0.64223861
165MP0009379_abnormal_foot_pigmentation0.62395008
166MP0004043_abnormal_pH_regulation0.61218659
167MP0009250_abnormal_appendicular_skeleto0.59460039
168MP0003718_maternal_effect0.59348068
169MP0004782_abnormal_surfactant_physiolog0.59248009
170MP0008770_decreased_survivor_rate0.58771935
171MP0002019_abnormal_tumor_incidence0.58231159
172MP0005376_homeostasis/metabolism_phenot0.57957169
173MP0009333_abnormal_splenocyte_physiolog0.57842610
174MP0001727_abnormal_embryo_implantation0.57613635
175MP0001145_abnormal_male_reproductive0.57039145
176MP0000358_abnormal_cell_content/0.56628013

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.10721637
2Hypochromic microcytic anemia (HP:0004840)5.39509391
3Pancreatic cysts (HP:0001737)4.37145453
4Hepatoblastoma (HP:0002884)4.32070501
5Pancreatic fibrosis (HP:0100732)4.22480877
6Multiple enchondromatosis (HP:0005701)4.20088382
7Chromosomal breakage induced by crosslinking agents (HP:0003221)4.17781964
8Rib fusion (HP:0000902)4.08912504
9Molar tooth sign on MRI (HP:0002419)4.00010428
10Abnormality of midbrain morphology (HP:0002418)4.00010428
11Nephroblastoma (Wilms tumor) (HP:0002667)3.95984371
12Anomalous pulmonary venous return (HP:0010772)3.95717428
13True hermaphroditism (HP:0010459)3.86241619
14Ependymoma (HP:0002888)3.82773354
15Rectal fistula (HP:0100590)3.79765769
16Rectovaginal fistula (HP:0000143)3.79765769
17Embryonal renal neoplasm (HP:0011794)3.71567787
18Chromsome breakage (HP:0040012)3.67847740
19Aplasia/Hypoplasia of the fovea (HP:0008060)3.61017952
20Hypoplasia of the fovea (HP:0007750)3.61017952
21Abnormality of the pulmonary veins (HP:0011718)3.57359882
22Nephronophthisis (HP:0000090)3.54589518
23Partial duplication of thumb phalanx (HP:0009944)3.53321992
24Congenital stationary night blindness (HP:0007642)3.41869372
25Neoplasm of striated muscle (HP:0009728)3.41174078
26Abnormal lung lobation (HP:0002101)3.39190041
27Intestinal fistula (HP:0100819)3.32339303
28Rhabdomyosarcoma (HP:0002859)3.23449962
29Vaginal fistula (HP:0004320)3.19165553
303-Methylglutaconic aciduria (HP:0003535)3.13602576
31Abnormality of the renal medulla (HP:0100957)3.09848141
32Partial duplication of the phalanx of hand (HP:0009999)3.08393089
33Supernumerary spleens (HP:0009799)3.07078353
34Hyperinsulinemic hypoglycemia (HP:0000825)3.06520167
35Type II lissencephaly (HP:0007260)3.03826738
36Testicular atrophy (HP:0000029)2.99955103
37Meckel diverticulum (HP:0002245)2.99367482
38Impulsivity (HP:0100710)2.98606480
39Fused cervical vertebrae (HP:0002949)2.92380904
40Progressive external ophthalmoplegia (HP:0000590)2.89681844
41Medial flaring of the eyebrow (HP:0010747)2.87540826
42Reduced antithrombin III activity (HP:0001976)2.81691208
43Birth length less than 3rd percentile (HP:0003561)2.81071440
44Nasolacrimal duct obstruction (HP:0000579)2.79841580
45Cystic liver disease (HP:0006706)2.79289384
46Abnormality of the renal cortex (HP:0011035)2.79068353
47Bifid tongue (HP:0010297)2.75326449
48Abnormality of the ileum (HP:0001549)2.74898831
49Trismus (HP:0000211)2.74342804
50Aplastic anemia (HP:0001915)2.62021799
51Abnormality of the salivary glands (HP:0010286)2.61320184
52Abnormality of the fovea (HP:0000493)2.59880181
53Microvesicular hepatic steatosis (HP:0001414)2.59298691
54Abnormality of alanine metabolism (HP:0010916)2.57678710
55Hyperalaninemia (HP:0003348)2.57678710
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.57678710
57Congenital, generalized hypertrichosis (HP:0004540)2.57340957
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.57189047
59Aplasia/Hypoplasia of the uvula (HP:0010293)2.52740971
60Aplasia/hypoplasia of the humerus (HP:0006507)2.49584893
61Chronic hepatic failure (HP:0100626)2.48633775
62Sclerocornea (HP:0000647)2.47568989
63Abnormality of the phalanges of the hallux (HP:0010057)2.47370276
64Abolished electroretinogram (ERG) (HP:0000550)2.45940872
65Hyperglycinemia (HP:0002154)2.45583932
66Hypochromic anemia (HP:0001931)2.44910507
67Abnormality of glycolysis (HP:0004366)2.43321729
68Increased serum pyruvate (HP:0003542)2.43321729
69Progressive cerebellar ataxia (HP:0002073)2.43202749
70Progressive inability to walk (HP:0002505)2.39717906
71Glossoptosis (HP:0000162)2.39652874
72Aplasia/Hypoplasia of the tibia (HP:0005772)2.39405775
73Methylmalonic acidemia (HP:0002912)2.39358430
74Inability to walk (HP:0002540)2.38138582
75Premature ovarian failure (HP:0008209)2.37345209
76Cerebellar dysplasia (HP:0007033)2.36238742
77Abnormality of chromosome segregation (HP:0002916)2.35553657
78Abnormality of the preputium (HP:0100587)2.34714888
79Tubular atrophy (HP:0000092)2.34702227
80Sensory axonal neuropathy (HP:0003390)2.34332382
81Attenuation of retinal blood vessels (HP:0007843)2.33857848
82Duplication of thumb phalanx (HP:0009942)2.31653431
83Abnormality of the pons (HP:0007361)2.29472424
84Hypoplasia of the pons (HP:0012110)2.28946444
85Type I transferrin isoform profile (HP:0003642)2.27946865
86Lipid accumulation in hepatocytes (HP:0006561)2.25835541
87Gait imbalance (HP:0002141)2.25481842
88Colon cancer (HP:0003003)2.25471271
89Abnormality of the lower motor neuron (HP:0002366)2.24532963
90Gaze-evoked nystagmus (HP:0000640)2.24467443
91Acute necrotizing encephalopathy (HP:0006965)2.24025729
92Mitochondrial inheritance (HP:0001427)2.23428168
93Congenital primary aphakia (HP:0007707)2.23248298
94Astrocytoma (HP:0009592)2.21870028
95Abnormality of the astrocytes (HP:0100707)2.21870028
96Abnormality of chromosome stability (HP:0003220)2.21504406
97Short humerus (HP:0005792)2.20827439
98Anencephaly (HP:0002323)2.19503951
99Furrowed tongue (HP:0000221)2.19184128
100Periauricular skin pits (HP:0100277)2.18335436
101Preauricular pit (HP:0004467)2.18335436
102Duodenal stenosis (HP:0100867)2.17917256
103Small intestinal stenosis (HP:0012848)2.17917256
104Aplasia/Hypoplasia of the tongue (HP:0010295)2.17712210
105Pendular nystagmus (HP:0012043)2.16434736
106Abnormal biliary tract physiology (HP:0012439)2.15694413
107Bile duct proliferation (HP:0001408)2.15694413
108Lissencephaly (HP:0001339)2.15474848
109Increased CSF lactate (HP:0002490)2.15036770
110Decreased central vision (HP:0007663)2.14619487
111Patellar aplasia (HP:0006443)2.14136781
112Facial cleft (HP:0002006)2.13437317
113Upper limb muscle weakness (HP:0003484)2.13023077
114Abnormality of the lacrimal duct (HP:0011481)2.12929826
115Broad-based gait (HP:0002136)2.12898750
116Chorioretinal atrophy (HP:0000533)2.11997004
117Ragged-red muscle fibers (HP:0003200)2.11797585
118Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.11612123
119Methylmalonic aciduria (HP:0012120)2.11197940
120Secondary amenorrhea (HP:0000869)2.10226885
121Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10139155
122Male pseudohermaphroditism (HP:0000037)2.09810619
123Nephrogenic diabetes insipidus (HP:0009806)2.09483634
124Hyperventilation (HP:0002883)2.09372443
125Abnormal drinking behavior (HP:0030082)2.09286646
126Polydipsia (HP:0001959)2.09286646
127Aplasia/Hypoplasia of the macula (HP:0008059)2.08802541
128Acute encephalopathy (HP:0006846)2.08008577
129Progressive macrocephaly (HP:0004481)2.06602959
130Genetic anticipation (HP:0003743)2.06426638
131Genital tract atresia (HP:0001827)2.06087537
132Microretrognathia (HP:0000308)2.05890701
133Preauricular skin tag (HP:0000384)2.05758397
134Large earlobe (HP:0009748)2.05229167
135Amyotrophic lateral sclerosis (HP:0007354)2.05056823
136Aplasia/Hypoplasia of the patella (HP:0006498)2.04767074
137Hypothermia (HP:0002045)2.02525004
138Abnormality of small intestinal villus morphology (HP:0011472)2.01764487
139Villous atrophy (HP:0011473)2.01764487
140Congenital hepatic fibrosis (HP:0002612)2.01685175
141Increased hepatocellular lipid droplets (HP:0006565)2.01121230
142Combined immunodeficiency (HP:0005387)2.00975076
143Dynein arm defect of respiratory motile cilia (HP:0012255)2.00923152
144Absent/shortened dynein arms (HP:0200106)2.00923152
145Large for gestational age (HP:0001520)2.00791718
146Abnormality of the labia minora (HP:0012880)2.00251349
147Triphalangeal thumb (HP:0001199)1.99966494
148Aplasia/Hypoplasia of the sternum (HP:0006714)1.99913314
149Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96209504
150Optic nerve hypoplasia (HP:0000609)1.95293409
151Vaginal atresia (HP:0000148)1.93802514
152Horizontal nystagmus (HP:0000666)1.93699336
153Increased corneal curvature (HP:0100692)1.93057096
154Keratoconus (HP:0000563)1.93057096
155Oligodactyly (hands) (HP:0001180)1.93017132
156Small hand (HP:0200055)1.92710601
157Bone marrow hypocellularity (HP:0005528)1.92696614
158Myelodysplasia (HP:0002863)1.91883064
159Embryonal neoplasm (HP:0002898)1.90459992
160Postaxial foot polydactyly (HP:0001830)1.89697063
161Short tibia (HP:0005736)1.89507949
162Pancreatic islet-cell hyperplasia (HP:0004510)1.87602795
163Shawl scrotum (HP:0000049)1.86874165
164Hyperglycinuria (HP:0003108)1.86379125
165Abnormality of the nasolacrimal system (HP:0000614)1.85815575
166Abnormal rod and cone electroretinograms (HP:0008323)1.85237903
167Increased IgM level (HP:0003496)1.85001334
168Abnormal cartilage morphology (HP:0002763)1.84895321
169Abnormality of the duodenum (HP:0002246)1.84351687
170Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83208085
171Hepatocellular necrosis (HP:0001404)1.83012229
172Medulloblastoma (HP:0002885)1.82543390
173Renal cortical cysts (HP:0000803)1.81961582
174Sparse eyelashes (HP:0000653)1.80152598
175Abnormal mitochondria in muscle tissue (HP:0008316)1.79478328
176Aplasia/Hypoplasia affecting the retina (HP:0008061)1.78267025
177Abnormal number of erythroid precursors (HP:0012131)1.77468404
178Abnormality of the intervertebral disk (HP:0005108)1.77231484
179Prominent occiput (HP:0000269)1.76641203
180Sloping forehead (HP:0000340)1.76426665
181Septo-optic dysplasia (HP:0100842)1.76198619
182Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.76093402
183Polyuria (HP:0000103)1.75224944
184Stomach cancer (HP:0012126)1.75039557
185Ectopic anus (HP:0004397)1.74845367
186Aplasia/hypoplasia of the uterus (HP:0008684)1.74757517
187Abnormality of glycine metabolism (HP:0010895)1.74156390
188Abnormality of serine family amino acid metabolism (HP:0010894)1.74156390
189Optic disc pallor (HP:0000543)1.73726212
190Dandy-Walker malformation (HP:0001305)1.72391443
191Pachygyria (HP:0001302)1.72125183
192Abnormality of serum amino acid levels (HP:0003112)1.71914998
193Poor coordination (HP:0002370)1.71347856

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.39960526
2FRK5.00120753
3GRK54.34266758
4GRK13.38128566
5GRK63.36723330
6ZAK3.22007928
7ADRBK23.16263384
8INSRR2.79534104
9TTK2.74769471
10EIF2AK12.54332827
11MAP3K42.52378096
12WNK32.50029066
13CSF1R2.48464878
14GRK72.47753972
15TNIK2.32559507
16NUAK12.31573037
17ERN12.30474659
18MAPK72.20082948
19STK102.15050443
20PINK12.12776080
21TGFBR22.06568503
22MAP4K22.01640337
23EIF2AK31.95119358
24AKT31.89919440
25MAP2K71.89291685
26PNCK1.85259815
27EIF2AK21.75184106
28CDK71.71703142
29MOS1.70147148
30MAPK131.67569974
31WNK41.65393083
32TYRO31.55248503
33SRPK11.52947740
34OXSR11.52259601
35PBK1.49634263
36WNK11.48923309
37MATK1.38467548
38ADRBK11.36140515
39WEE11.34587079
40PRKG21.30911530
41PLK11.27324893
42STK391.27047258
43CHEK21.26341676
44BRSK21.25538786
45BUB11.22232673
46TAOK31.17724682
47TRIM281.12295049
48HIPK21.08441950
49BRD41.07393378
50PLK31.06547748
51DYRK31.03907107
52ACVR1B1.03615845
53CAMKK21.02803804
54NME21.01005650
55CAMK41.00713177
56PRKCG0.99245960
57PAK30.97743641
58VRK10.95444085
59PAK40.92296369
60MST40.91557894
61TLK10.89239738
62TXK0.88663563
63CHEK10.87858245
64DYRK20.87058487
65CASK0.86231312
66PRKCE0.86132559
67PIK3CA0.85306943
68MKNK20.83742027
69DAPK20.82977368
70PLK20.82504393
71TSSK60.78526814
72VRK20.78186125
73CDK80.77749828
74BLK0.77295276
75EPHA40.77223044
76CSNK1G20.76804963
77MARK10.76398718
78CSNK1G10.75638695
79ITK0.75289171
80MAPK150.74188691
81BMPR1B0.74111952
82FGFR30.71678329
83CSK0.71161945
84BCKDK0.70121850
85MKNK10.69779841
86AURKA0.69220477
87NLK0.67699628
88CDC70.67642544
89TAF10.66992793
90EPHA20.65094144
91ATM0.65024923
92PKN10.64991388
93TIE10.64951730
94YES10.63924077
95CSNK1G30.62968539
96PTK2B0.61763378
97AURKB0.61559705
98CSNK1A1L0.61071562
99MARK20.58564396
100ERBB30.57979431
101MAPKAPK50.56813267
102STK160.56002125
103IRAK30.55673294
104EPHB10.53606186
105STK38L0.52834511
106NTRK20.52314475
107STK110.52295743
108STK40.50823552
109IKBKB0.50173949
110BCR0.49396156
111FGFR20.49340031
112NTRK30.48717732
113BRSK10.48465640
114NME10.48145295
115PRKCQ0.47790296
116ATR0.47668840
117CDK20.46426446
118MELK0.45427523
119NEK20.45315849
120CDK40.44945671
121CSNK1A10.43386108
122CAMK2A0.43377304
123PRKCI0.42959007
124PRKACA0.41271989
125CAMK10.39609543
126CDK190.37319079
127MAPK120.36049079
128MUSK0.35685120
129DYRK1A0.35581593
130BMPR20.34558546
131NTRK10.34514786
132OBSCN0.34407463
133CDK10.33989448
134PRKCD0.33287152
135IGF1R0.32860730
136CHUK0.32623394
137CAMK1D0.32473091
138AKT20.32253406
139TEC0.31185977
140PIM20.31166166
141PRKCZ0.30611579
142PIM10.30242408
143TGFBR10.30096565
144PRKCA0.29972516
145MAP2K40.29709357
146IRAK10.29444473
147IRAK40.28768154
148ERBB20.28721845
149CSNK2A10.28687111
150CLK10.27557262
151IRAK20.26054990
152PAK10.26022875
153MAPKAPK20.25658778
154PLK40.25191342
155RPS6KA50.23703440
156MAP2K60.23520803
157INSR0.22473212
158CSNK1E0.22054299
159STK30.20222345
160MAPK40.20023571
161LATS20.19107467

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.57511650
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.13854387
3Ribosome_Homo sapiens_hsa030103.80052184
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.78190390
5RNA polymerase_Homo sapiens_hsa030202.79443717
6Phototransduction_Homo sapiens_hsa047442.49399178
7Arachidonic acid metabolism_Homo sapiens_hsa005902.47213530
8Homologous recombination_Homo sapiens_hsa034402.44403463
9Fanconi anemia pathway_Homo sapiens_hsa034602.41610558
10DNA replication_Homo sapiens_hsa030302.40459370
11Spliceosome_Homo sapiens_hsa030402.36101510
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.29266465
13Mismatch repair_Homo sapiens_hsa034302.26087603
14RNA transport_Homo sapiens_hsa030132.23216901
15Proteasome_Homo sapiens_hsa030502.19214395
16Selenocompound metabolism_Homo sapiens_hsa004502.06124679
17RNA degradation_Homo sapiens_hsa030182.04382913
18Nicotine addiction_Homo sapiens_hsa050332.04334958
19Butanoate metabolism_Homo sapiens_hsa006501.98926596
20Basal transcription factors_Homo sapiens_hsa030221.91459246
21Linoleic acid metabolism_Homo sapiens_hsa005911.91212851
22Nitrogen metabolism_Homo sapiens_hsa009101.90153751
23Base excision repair_Homo sapiens_hsa034101.85204686
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.84836099
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.75385217
26Non-homologous end-joining_Homo sapiens_hsa034501.75302201
27Cell cycle_Homo sapiens_hsa041101.73219836
28Fructose and mannose metabolism_Homo sapiens_hsa000511.72654680
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.70212754
30Pyrimidine metabolism_Homo sapiens_hsa002401.66554061
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62638102
32Caffeine metabolism_Homo sapiens_hsa002321.62484504
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57929944
34Protein export_Homo sapiens_hsa030601.57022741
35mRNA surveillance pathway_Homo sapiens_hsa030151.43024518
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.37078868
37Propanoate metabolism_Homo sapiens_hsa006401.36317259
38Nucleotide excision repair_Homo sapiens_hsa034201.35740625
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.34832759
40Taste transduction_Homo sapiens_hsa047421.34373664
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31098481
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.24441230
43Galactose metabolism_Homo sapiens_hsa000521.24052996
44Ether lipid metabolism_Homo sapiens_hsa005651.23780104
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16841861
46One carbon pool by folate_Homo sapiens_hsa006701.16701287
47Olfactory transduction_Homo sapiens_hsa047401.16359762
48p53 signaling pathway_Homo sapiens_hsa041151.15837964
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12733508
50Cardiac muscle contraction_Homo sapiens_hsa042601.11627172
51Morphine addiction_Homo sapiens_hsa050321.06515680
52Peroxisome_Homo sapiens_hsa041461.02803504
53Folate biosynthesis_Homo sapiens_hsa007901.02109902
54Primary bile acid biosynthesis_Homo sapiens_hsa001201.01505028
55Herpes simplex infection_Homo sapiens_hsa051681.00195863
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00078913
57Chemical carcinogenesis_Homo sapiens_hsa052041.00036165
58Primary immunodeficiency_Homo sapiens_hsa053400.97812295
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97500289
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96047349
61Oxidative phosphorylation_Homo sapiens_hsa001900.93355736
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90492575
63Insulin secretion_Homo sapiens_hsa049110.89883372
64Glutamatergic synapse_Homo sapiens_hsa047240.87437450
65Thyroid cancer_Homo sapiens_hsa052160.86289737
66Huntingtons disease_Homo sapiens_hsa050160.84203192
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80657066
68Vitamin digestion and absorption_Homo sapiens_hsa049770.80112773
69Glycerolipid metabolism_Homo sapiens_hsa005610.79166974
70GABAergic synapse_Homo sapiens_hsa047270.77760595
71Purine metabolism_Homo sapiens_hsa002300.77309258
72Ovarian steroidogenesis_Homo sapiens_hsa049130.75646505
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70630737
74Circadian entrainment_Homo sapiens_hsa047130.69209398
75ABC transporters_Homo sapiens_hsa020100.67548885
76Parkinsons disease_Homo sapiens_hsa050120.67274605
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64673335
78beta-Alanine metabolism_Homo sapiens_hsa004100.64072217
79Retinol metabolism_Homo sapiens_hsa008300.63051732
80Regulation of autophagy_Homo sapiens_hsa041400.62933694
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62723018
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62646576
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.61180319
84Fat digestion and absorption_Homo sapiens_hsa049750.60648338
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60077667
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.58455363
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56458870
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.55585412
89Glutathione metabolism_Homo sapiens_hsa004800.55324868
90Asthma_Homo sapiens_hsa053100.53929455
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53105345
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.51869134
93Metabolic pathways_Homo sapiens_hsa011000.51365684
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51322178
95Fatty acid elongation_Homo sapiens_hsa000620.50965677
96Calcium signaling pathway_Homo sapiens_hsa040200.50586962
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49486050
98Hematopoietic cell lineage_Homo sapiens_hsa046400.49046590
99Collecting duct acid secretion_Homo sapiens_hsa049660.45191861
100Epstein-Barr virus infection_Homo sapiens_hsa051690.45045080
101Autoimmune thyroid disease_Homo sapiens_hsa053200.44635402
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.44595424
103Other glycan degradation_Homo sapiens_hsa005110.42553583
104African trypanosomiasis_Homo sapiens_hsa051430.42136136
105Cocaine addiction_Homo sapiens_hsa050300.42106767
106Sulfur relay system_Homo sapiens_hsa041220.42073664
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42021592
108Allograft rejection_Homo sapiens_hsa053300.41553367
109Alzheimers disease_Homo sapiens_hsa050100.41306650
110Dopaminergic synapse_Homo sapiens_hsa047280.39127495
111MicroRNAs in cancer_Homo sapiens_hsa052060.38932433
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38541579
113Pathways in cancer_Homo sapiens_hsa052000.38540061
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37903275
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36325349
116Histidine metabolism_Homo sapiens_hsa003400.36166348
117Mineral absorption_Homo sapiens_hsa049780.35427765
118Dorso-ventral axis formation_Homo sapiens_hsa043200.35145426
119Tryptophan metabolism_Homo sapiens_hsa003800.34440325
120Basal cell carcinoma_Homo sapiens_hsa052170.34155327
121Pentose phosphate pathway_Homo sapiens_hsa000300.31892692
122Circadian rhythm_Homo sapiens_hsa047100.31380520
123Systemic lupus erythematosus_Homo sapiens_hsa053220.30576876
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.29655346
125Steroid biosynthesis_Homo sapiens_hsa001000.29209801
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27881238
127Hedgehog signaling pathway_Homo sapiens_hsa043400.26386873
128Apoptosis_Homo sapiens_hsa042100.26385689
129Notch signaling pathway_Homo sapiens_hsa043300.24864362
130Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.24847479
131Graft-versus-host disease_Homo sapiens_hsa053320.23851167
132Sphingolipid metabolism_Homo sapiens_hsa006000.23177536
133Serotonergic synapse_Homo sapiens_hsa047260.22884205
134Sulfur metabolism_Homo sapiens_hsa009200.20815440
135Wnt signaling pathway_Homo sapiens_hsa043100.19997795
136Antigen processing and presentation_Homo sapiens_hsa046120.19618702
137Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19468435
138Viral carcinogenesis_Homo sapiens_hsa052030.19146802
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18169855
140HTLV-I infection_Homo sapiens_hsa051660.15070170
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.14182202
142Measles_Homo sapiens_hsa051620.13933940

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