KIR2DS4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)7.84523826
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.84523826
3cellular response to interleukin-15 (GO:0071350)7.60302001
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.54503548
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.18330251
6response to interleukin-15 (GO:0070672)7.06170450
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.71984262
8antigen processing and presentation of endogenous antigen (GO:0019883)6.58004724
9regulation of B cell receptor signaling pathway (GO:0050855)6.32009418
10positive regulation of gamma-delta T cell activation (GO:0046645)6.20133871
11activated T cell proliferation (GO:0050798)6.16971761
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.08845129
13leukocyte aggregation (GO:0070486)5.66689256
14negative T cell selection (GO:0043383)4.88629985
15negative thymic T cell selection (GO:0045060)4.84561302
16regulation of natural killer cell mediated immunity (GO:0002715)4.81993249
17regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.81993249
18negative regulation of lymphocyte mediated immunity (GO:0002707)4.55773843
19interferon-gamma production (GO:0032609)4.43000520
20regulation of gamma-delta T cell activation (GO:0046643)4.42570483
21positive thymic T cell selection (GO:0045059)4.41407821
22regulation of gamma-delta T cell differentiation (GO:0045586)4.36361001
23neutrophil activation involved in immune response (GO:0002283)4.28936804
24macrophage activation involved in immune response (GO:0002281)4.28420323
25B cell receptor signaling pathway (GO:0050853)4.27033331
26antigen processing and presentation via MHC class Ib (GO:0002475)4.25254477
27positive T cell selection (GO:0043368)4.24752289
28negative regulation of T cell mediated immunity (GO:0002710)4.23987979
29regulation of B cell differentiation (GO:0045577)4.14384989
30cellular defense response (GO:0006968)4.12056673
31detection of bacterium (GO:0016045)4.11658428
32regulation of T cell tolerance induction (GO:0002664)4.05518203
33detection of other organism (GO:0098543)4.01614990
34positive regulation of T cell mediated cytotoxicity (GO:0001916)4.00098398
35negative regulation of leukocyte mediated immunity (GO:0002704)3.97940680
36regulation of T cell mediated cytotoxicity (GO:0001914)3.97707545
37positive regulation of natural killer cell mediated immunity (GO:0002717)3.97470861
38regulation of leukocyte mediated cytotoxicity (GO:0001910)3.97167865
39positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.92996293
40type I interferon signaling pathway (GO:0060337)3.89273089
41cellular response to type I interferon (GO:0071357)3.89273089
42response to interferon-beta (GO:0035456)3.89060272
43response to type I interferon (GO:0034340)3.86843283
44negative regulation of interleukin-12 production (GO:0032695)3.83441853
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.77601757
46positive regulation by organism of defense response of other organism involved in symbiotic interact3.77601757
47modulation by symbiont of host immune response (GO:0052553)3.77601757
48positive regulation by symbiont of host defense response (GO:0052509)3.77601757
49modulation by symbiont of host defense response (GO:0052031)3.77601757
50modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.77601757
51positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.72691176
52thymic T cell selection (GO:0045061)3.70336370
53T cell selection (GO:0045058)3.68470324
54cytidine deamination (GO:0009972)3.67453362
55cytidine metabolic process (GO:0046087)3.67453362
56cytidine catabolic process (GO:0006216)3.67453362
57T cell migration (GO:0072678)3.66275011
58regulation of cell killing (GO:0031341)3.64736851
59positive regulation of cell killing (GO:0031343)3.62641206
60positive regulation of B cell differentiation (GO:0045579)3.61776913
61cellular extravasation (GO:0045123)3.61517914
62neutrophil activation (GO:0042119)3.61262854
63regulation of alpha-beta T cell proliferation (GO:0046640)3.61059190
64positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.54060667
65regulation of tolerance induction (GO:0002643)3.51151055
66positive regulation of granulocyte differentiation (GO:0030854)3.47349442
67cellular response to interferon-beta (GO:0035458)3.46135046
68microglial cell activation (GO:0001774)3.45586284
69granulocyte activation (GO:0036230)3.40685004
70regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.38975728
71pyrimidine ribonucleoside catabolic process (GO:0046133)3.38400057
72myeloid cell activation involved in immune response (GO:0002275)3.36516160
73antigen receptor-mediated signaling pathway (GO:0050851)3.35937836
74hepatocyte apoptotic process (GO:0097284)3.27559406
75mast cell activation (GO:0045576)3.24942305
76positive regulation of tolerance induction (GO:0002645)3.23594292
77interferon-gamma-mediated signaling pathway (GO:0060333)3.17558076
78regulation of interleukin-12 biosynthetic process (GO:0045075)3.16718168
79positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.16547326
80leukocyte migration involved in inflammatory response (GO:0002523)3.14585808
81positive regulation of defense response to virus by host (GO:0002230)3.11465248
82T cell receptor signaling pathway (GO:0050852)3.10750436
83respiratory burst (GO:0045730)3.07908802
84leukocyte degranulation (GO:0043299)3.07101615
85regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.05649427
86positive regulation of isotype switching (GO:0045830)3.03989186
87negative regulation of innate immune response (GO:0045824)3.03742724
88positive regulation of mast cell activation (GO:0033005)3.01336823
89detection of external biotic stimulus (GO:0098581)3.00314108
90regulation of regulatory T cell differentiation (GO:0045589)2.98899793
91regulation of isotype switching to IgG isotypes (GO:0048302)2.94630520
92negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.93426922
93immunoglobulin mediated immune response (GO:0016064)2.89561844
94negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.87430897
95natural killer cell differentiation (GO:0001779)2.87110457
96regulation of T cell mediated immunity (GO:0002709)2.86341420
97positive regulation of calcium-mediated signaling (GO:0050850)2.85640837
98positive regulation of lymphocyte mediated immunity (GO:0002708)2.84942307
99response to host immune response (GO:0052572)2.82512008
100response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.82512008

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human5.86398623
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.76607077
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.35394052
4IRF8_22096565_ChIP-ChIP_GC-B_Human5.24821945
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.01968546
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.02626545
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.82850094
8RUNX_20019798_ChIP-Seq_JUKART_Human3.61999096
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.39644549
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.26971348
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.24887724
12MYB_26560356_Chip-Seq_TH2_Human3.05506782
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.71051174
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.63682510
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.63542519
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.58288616
17MAF_26560356_Chip-Seq_TH1_Human2.58042339
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.52478913
19MYB_26560356_Chip-Seq_TH1_Human2.42520872
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.39901294
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31835434
22SPI1_23547873_ChIP-Seq_NB4_Human2.27253944
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.25527765
24UTX_26944678_Chip-Seq_JUKART_Human2.17797763
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12788225
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.07993061
27SPI1_23127762_ChIP-Seq_K562_Human2.06401538
28GATA3_27048872_Chip-Seq_THYMUS_Human2.03558264
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.01969660
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.93067742
31VDR_24763502_ChIP-Seq_THP-1_Human1.91613210
32MAF_26560356_Chip-Seq_TH2_Human1.84139989
33MYC_22102868_ChIP-Seq_BL_Human1.82643051
34VDR_21846776_ChIP-Seq_THP-1_Human1.80387170
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76312426
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72876467
37GATA3_26560356_Chip-Seq_TH2_Human1.68756008
38SCL_19346495_ChIP-Seq_HPC-7_Human1.68433224
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.65752889
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.58160954
41RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.56328430
42TCF7_22412390_ChIP-Seq_EML_Mouse1.52543373
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49762800
44VDR_24787735_ChIP-Seq_THP-1_Human1.47459044
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42591170
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42035993
47KDM2B_26808549_Chip-Seq_DND41_Human1.40824182
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39879384
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39810028
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37275576
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.30937074
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22603359
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21836081
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21483780
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18322092
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17712666
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15960065
58GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15935246
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11088071
60VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.10741196
61PU_27001747_Chip-Seq_BMDM_Mouse1.10379278
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10200232
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09021046
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.08403193
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.08307951
66GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04958205
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02860360
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01332907
69CIITA_25753668_ChIP-Seq_RAJI_Human1.01019331
70CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97584245
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97511273
72KDM2B_26808549_Chip-Seq_JURKAT_Human0.97442986
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96084172
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95690171
75ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94086627
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93295193
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91865494
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89330144
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89018580
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87811048
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87760750
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87446866
83PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87297321
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83695888
85GATA1_19941826_ChIP-Seq_K562_Human0.83132433
86IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82030222
87GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80933015
88RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80142099
89SMRT_27268052_Chip-Seq_Bcells_Human0.80013854
90GATA3_26560356_Chip-Seq_TH1_Human0.78904957
91SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76442918
92BCL6_27268052_Chip-Seq_Bcells_Human0.73929389
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72625249
94BCOR_27268052_Chip-Seq_Bcells_Human0.72273555
95PU.1_20513432_ChIP-Seq_Bcells_Mouse0.71516863
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71021694
97GATA2_21666600_ChIP-Seq_HMVEC_Human0.70578588
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.69065868
99GATA1_22025678_ChIP-Seq_K562_Human0.68215613
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.67678176

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.82562484
2MP0003763_abnormal_thymus_physiology4.35211086
3MP0001835_abnormal_antigen_presentation4.11635072
4MP0006082_CNS_inflammation3.94416840
5MP0003436_decreased_susceptibility_to3.51034936
6MP0003724_increased_susceptibility_to3.29048158
7MP0001800_abnormal_humoral_immune3.25922801
8MP0005387_immune_system_phenotype3.05631352
9MP0001790_abnormal_immune_system3.05631352
10MP0005000_abnormal_immune_tolerance2.95794623
11MP0005025_abnormal_response_to2.87497629
12MP0002723_abnormal_immune_serum2.83415008
13MP0000685_abnormal_immune_system2.77777418
14MP0002420_abnormal_adaptive_immunity2.75733100
15MP0001819_abnormal_immune_cell2.72305419
16MP0002419_abnormal_innate_immunity2.71743793
17MP0009785_altered_susceptibility_to2.65935907
18MP0003183_abnormal_peptide_metabolism2.58432543
19MP0009333_abnormal_splenocyte_physiolog2.58349238
20MP0002452_abnormal_antigen_presenting2.56535930
21MP0002405_respiratory_system_inflammati2.42458286
22MP0003300_gastrointestinal_ulcer2.34416233
23MP0000703_abnormal_thymus_morphology2.28449503
24MP0002398_abnormal_bone_marrow2.20554073
25MP0000716_abnormal_immune_system2.12848231
26MP0003303_peritoneal_inflammation1.95539341
27MP0002148_abnormal_hypersensitivity_rea1.90720193
28MP0002722_abnormal_immune_system1.89702485
29MP0000689_abnormal_spleen_morphology1.89446041
30MP0003866_abnormal_defecation1.81479698
31MP0001851_eye_inflammation1.79108971
32MP0010155_abnormal_intestine_physiology1.77486011
33MP0002132_abnormal_respiratory_system1.71415525
34MP0005464_abnormal_platelet_physiology1.67943374
35MP0003690_abnormal_glial_cell1.66556699
36MP0001845_abnormal_inflammatory_respons1.65495058
37MP0004381_abnormal_hair_follicle1.65130747
38MP0002429_abnormal_blood_cell1.61550468
39MP0001533_abnormal_skeleton_physiology1.51430914
40MP0001873_stomach_inflammation1.50709768
41MP0002166_altered_tumor_susceptibility1.50202431
42MP0001853_heart_inflammation1.49934561
43MP0000858_altered_metastatic_potential1.38544452
44MP0008057_abnormal_DNA_replication1.38418270
45MP0008469_abnormal_protein_level1.34470679
46MP0002396_abnormal_hematopoietic_system1.33763141
47MP0004947_skin_inflammation1.32283575
48MP0004883_abnormal_blood_vessel1.26109796
49MP0005310_abnormal_salivary_gland1.25510307
50MP0002998_abnormal_bone_remodeling1.24968870
51MP0003045_fibrosis1.22862958
52MP0004142_abnormal_muscle_tone1.19437717
53MP0002277_abnormal_respiratory_mucosa1.17990350
54MP0003172_abnormal_lysosome_physiology1.16699682
55MP0003191_abnormal_cellular_cholesterol1.07169530
56MP0000569_abnormal_digit_pigmentation1.05748458
57MP0005075_abnormal_melanosome_morpholog0.98779541
58MP0005377_hearing/vestibular/ear_phenot0.97934780
59MP0003878_abnormal_ear_physiology0.97934780
60MP0009764_decreased_sensitivity_to0.92603797
61MP0009763_increased_sensitivity_to0.92489421
62MP0002006_tumorigenesis0.88468992
63MP0001986_abnormal_taste_sensitivity0.87532922
64MP0008260_abnormal_autophagy0.86108719
65MP0005166_decreased_susceptibility_to0.83625121
66MP0004130_abnormal_muscle_cell0.82539967
67MP0002332_abnormal_exercise_endurance0.82382575
68MP0003448_altered_tumor_morphology0.81169741
69MP0005164_abnormal_response_to0.81060196
70MP0005451_abnormal_body_composition0.80944000
71MP0002933_joint_inflammation0.80231386
72MP0002163_abnormal_gland_morphology0.71856777
73MP0000015_abnormal_ear_pigmentation0.69619042
74MP0002138_abnormal_hepatobiliary_system0.66952619
75MP0003828_pulmonary_edema0.65854895
76MP0004510_myositis0.64857416
77MP0003075_altered_response_to0.64539123
78MP0000920_abnormal_myelination0.64379375
79MP0009278_abnormal_bone_marrow0.63766482
80MP0002019_abnormal_tumor_incidence0.62205225
81MP0000465_gastrointestinal_hemorrhage0.60643460
82MP0008873_increased_physiological_sensi0.60151107
83MP0001663_abnormal_digestive_system0.59601090
84MP0002693_abnormal_pancreas_physiology0.59464570
85MP0005376_homeostasis/metabolism_phenot0.57425456
86MP0005645_abnormal_hypothalamus_physiol0.57113004
87MP0005390_skeleton_phenotype0.56875122
88MP0000249_abnormal_blood_vessel0.56096117
89MP0003795_abnormal_bone_structure0.52796792
90MP0000604_amyloidosis0.52582910
91MP0005319_abnormal_enzyme/_coenzyme0.49570909
92MP0005266_abnormal_metabolism0.49379847
93MP0002009_preneoplasia0.49193553
94MP0000490_abnormal_crypts_of0.47316347
95MP0003943_abnormal_hepatobiliary_system0.46600665
96MP0005334_abnormal_fat_pad0.45543943
97MP0004185_abnormal_adipocyte_glucose0.44262195
98MP0003959_abnormal_lean_body0.44148745
99MP0009765_abnormal_xenobiotic_induced0.43591145
100MP0001765_abnormal_ion_homeostasis0.43137068

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.56891962
2T lymphocytopenia (HP:0005403)6.31999566
3Abnormality of T cell number (HP:0011839)5.76003368
4Abnormal delayed hypersensitivity skin test (HP:0002963)5.59111482
5Elevated erythrocyte sedimentation rate (HP:0003565)5.23572544
6Recurrent cutaneous fungal infections (HP:0011370)5.18267105
7Chronic mucocutaneous candidiasis (HP:0002728)5.18267105
8Recurrent fungal infections (HP:0002841)4.89084795
9Myositis (HP:0100614)4.69218910
10Encephalitis (HP:0002383)4.68026799
11Abnormality of T cells (HP:0002843)4.66839713
12Recurrent bacterial skin infections (HP:0005406)4.64157462
13Stomatitis (HP:0010280)4.55473372
14Recurrent abscess formation (HP:0002722)4.47668268
15Panhypogammaglobulinemia (HP:0003139)4.40547031
16Abnormality of macrophages (HP:0004311)4.36861343
17Orchitis (HP:0100796)4.35716577
18Retrobulbar optic neuritis (HP:0100654)4.35396819
19Optic neuritis (HP:0100653)4.35396819
20Meningitis (HP:0001287)4.14154134
21Recurrent skin infections (HP:0001581)4.05277890
22Recurrent bronchitis (HP:0002837)4.01828249
23Increased IgE level (HP:0003212)3.83577323
24Agammaglobulinemia (HP:0004432)3.81613478
25Recurrent viral infections (HP:0004429)3.53971157
26Gastrointestinal infarctions (HP:0005244)3.52156738
27Severe combined immunodeficiency (HP:0004430)3.47445447
28Leukocytosis (HP:0001974)3.44291524
29Spontaneous hematomas (HP:0007420)3.42349579
30Vasculitis (HP:0002633)3.41066977
31Pustule (HP:0200039)3.30775052
32Chronic obstructive pulmonary disease (HP:0006510)3.29447677
33Obstructive lung disease (HP:0006536)3.29447677
34Keratoconjunctivitis sicca (HP:0001097)3.21187863
35Abnormality of T cell physiology (HP:0011840)3.19482246
36Mediastinal lymphadenopathy (HP:0100721)3.18226710
37Recurrent gram-negative bacterial infections (HP:0005420)3.16073603
38Abnormality of eosinophils (HP:0001879)3.15950779
39Inflammation of the large intestine (HP:0002037)3.15268211
40IgG deficiency (HP:0004315)3.11774861
41Gastrointestinal inflammation (HP:0004386)3.11289775
42Chronic diarrhea (HP:0002028)3.08231092
43Gingivitis (HP:0000230)3.07628724
44Granulocytopenia (HP:0001913)3.03959532
45Pulmonary infiltrates (HP:0002113)2.97909589
46Eosinophilia (HP:0001880)2.97528885
47Colitis (HP:0002583)2.95309063
48Keratoconjunctivitis (HP:0001096)2.94669648
49Increased IgM level (HP:0003496)2.83491045
50Chest pain (HP:0100749)2.80303711
51Viral hepatitis (HP:0006562)2.78497587
52Hypoplasia of the thymus (HP:0000778)2.73661211
53Joint swelling (HP:0001386)2.73387654
54Combined immunodeficiency (HP:0005387)2.64798333
55Lymphopenia (HP:0001888)2.62809934
56Hemiplegia (HP:0002301)2.60820780
57Petechiae (HP:0000967)2.55174071
58Autoimmune hemolytic anemia (HP:0001890)2.52826450
59Hypoproteinemia (HP:0003075)2.50650208
60Hypochromic microcytic anemia (HP:0004840)2.45553634
61Abnormality of cells of the lymphoid lineage (HP:0012140)2.44487185
62Hypochromic anemia (HP:0001931)2.42591438
63Nasal polyposis (HP:0100582)2.41308964
64Hemoptysis (HP:0002105)2.41203031
65Chronic otitis media (HP:0000389)2.40956509
66Pulmonary embolism (HP:0002204)2.38154309
67Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.38130957
68Urticaria (HP:0001025)2.35828524
69Anorexia (HP:0002039)2.32076963
70Abnormality of the pleura (HP:0002103)2.31059391
71Prolonged bleeding time (HP:0003010)2.29860565
72Hypergammaglobulinemia (HP:0010702)2.26319406
73Arterial thrombosis (HP:0004420)2.25402593
74Gingival bleeding (HP:0000225)2.23957258
75Bronchitis (HP:0012387)2.21208226
76Slow saccadic eye movements (HP:0000514)2.19761631
77Cellulitis (HP:0100658)2.16537330
78Abnormality of the fingertips (HP:0001211)2.14818502
79Microcytic anemia (HP:0001935)2.14596573
80Glomerulopathy (HP:0100820)2.13691969
81Epistaxis (HP:0000421)2.13615648
82Pigmentary retinal degeneration (HP:0001146)2.12065681
83Sepsis (HP:0100806)2.08823907
84Osteomyelitis (HP:0002754)2.08185312
85Lymphoma (HP:0002665)2.04541361
86Episodic fever (HP:0001954)2.03579170
87Purpura (HP:0000979)2.03207541
88Acne (HP:0001061)2.02442962
89Papilledema (HP:0001085)2.01791535
90Gangrene (HP:0100758)2.00222111
91Abnormality of the pericardium (HP:0001697)2.00071319
92Micronodular cirrhosis (HP:0001413)1.99923331
93Abnormality of binocular vision (HP:0011514)1.99732541
94Diplopia (HP:0000651)1.99732541
95Basal ganglia calcification (HP:0002135)1.97923809
96Stomach cancer (HP:0012126)1.97264301
97Thyroiditis (HP:0100646)1.92055216
98Abnormality of the nasal mucosa (HP:0000433)1.91635031
99Subacute progressive viral hepatitis (HP:0006572)1.88763097
100Abnormality of glycosphingolipid metabolism (HP:0004343)1.88047819

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.04336506
2MAP4K14.73904874
3EPHB13.71014471
4RIPK43.00165963
5EPHA32.95927266
6CDK32.92164585
7IRAK42.66805112
8MAP2K32.60202816
9FES2.35610041
10CSK2.32766875
11JAK12.16856618
12STK102.16069284
13MAP3K32.10456597
14FGFR41.94417823
15TGFBR21.92175391
16BLK1.90951450
17ZAP701.88060420
18FRK1.85271883
19TNK21.83463602
20TYK21.82625995
21GRK71.68197402
22BTK1.67441569
23GRK61.58291260
24JAK31.56964694
25ITK1.42374627
26PRPF4B1.40422251
27TAOK11.38661144
28HCK1.38048805
29TAOK31.36220492
30SYK1.34657429
31FGFR31.33352420
32MOS1.30037602
33LCK1.26484244
34ERN11.25078382
35SIK31.24354170
36SGK31.21916914
37HIPK21.20149244
38IRAK11.17289067
39SGK21.12070102
40NLK1.11455083
41MARK31.11450003
42TRIB31.05008058
43TEC1.03381572
44PDK10.99142736
45MAP3K10.96366150
46LYN0.93519729
47IKBKE0.93481125
48JAK20.93172321
49STK380.89088807
50MAPK120.88505983
51MARK20.83199852
52PRKCQ0.79820174
53MAP3K130.77742702
54PRKCH0.75506039
55GRK50.71867573
56IKBKB0.71190713
57MAP2K60.70030493
58FGR0.69859448
59KIT0.67919687
60MAP3K140.67141637
61PTK2B0.66285911
62SGK2230.64016523
63SGK4940.64016523
64SIK20.63423244
65CDK40.63190361
66PIK3CG0.61514579
67MAP3K110.58580936
68PIM10.56994463
69YES10.56480619
70PRKD20.55409830
71TBK10.51128849
72PRKCE0.50815269
73CSF1R0.49798130
74PRKCG0.48609564
75FYN0.48586565
76RET0.46158473
77MAPKAPK20.45829370
78SMG10.44358247
79LRRK20.38702563
80KSR20.38552275
81DAPK20.38272447
82CSNK1D0.38052635
83MAPK70.37175047
84BMPR20.35735622
85RPS6KA40.35515253
86ADRBK10.33469435
87RPS6KL10.32072329
88RPS6KC10.32072329
89STK110.31704180
90CAMK40.31295869
91CAMKK20.31223641
92PTK60.30341182
93RPS6KA60.30303199
94PDPK10.29436017
95CHUK0.28637318
96MAP3K80.28514513
97DYRK1B0.28371764
98CDK120.27756687
99TESK20.22173471
100MAP3K70.22051330

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053325.54043618
2* Antigen processing and presentation_Homo sapiens_hsa046124.35025123
3* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.29066855
4Primary immunodeficiency_Homo sapiens_hsa053403.61418221
5Allograft rejection_Homo sapiens_hsa053302.56705152
6T cell receptor signaling pathway_Homo sapiens_hsa046602.46418664
7Autoimmune thyroid disease_Homo sapiens_hsa053202.45701094
8Osteoclast differentiation_Homo sapiens_hsa043802.27361714
9Measles_Homo sapiens_hsa051622.06660032
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.02282247
11B cell receptor signaling pathway_Homo sapiens_hsa046622.01447134
12Leishmaniasis_Homo sapiens_hsa051402.00237989
13Type I diabetes mellitus_Homo sapiens_hsa049401.98223305
14Staphylococcus aureus infection_Homo sapiens_hsa051501.96005617
15Viral myocarditis_Homo sapiens_hsa054161.93051931
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59408775
17Chemokine signaling pathway_Homo sapiens_hsa040621.54018587
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53668543
19Tuberculosis_Homo sapiens_hsa051521.50563914
20Malaria_Homo sapiens_hsa051441.50529212
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.50331194
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48431609
23Acute myeloid leukemia_Homo sapiens_hsa052211.41374673
24Hematopoietic cell lineage_Homo sapiens_hsa046401.39983137
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.39197114
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29913897
27Herpes simplex infection_Homo sapiens_hsa051681.21812239
28VEGF signaling pathway_Homo sapiens_hsa043701.18062935
29Toxoplasmosis_Homo sapiens_hsa051451.17860903
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17171807
31Influenza A_Homo sapiens_hsa051641.16476669
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16440082
33Hepatitis B_Homo sapiens_hsa051611.15412643
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.13581998
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09674879
36TNF signaling pathway_Homo sapiens_hsa046681.08146545
37Non-small cell lung cancer_Homo sapiens_hsa052231.06825638
38Pancreatic cancer_Homo sapiens_hsa052121.02840578
39Platelet activation_Homo sapiens_hsa046110.99551028
40Hepatitis C_Homo sapiens_hsa051600.96078310
41Intestinal immune network for IgA production_Homo sapiens_hsa046720.95577043
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92096567
43Asthma_Homo sapiens_hsa053100.91204994
44Epstein-Barr virus infection_Homo sapiens_hsa051690.86571970
45Shigellosis_Homo sapiens_hsa051310.84793557
46HTLV-I infection_Homo sapiens_hsa051660.81695740
47Apoptosis_Homo sapiens_hsa042100.79484872
48Endocytosis_Homo sapiens_hsa041440.77838436
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76851495
50Sphingolipid signaling pathway_Homo sapiens_hsa040710.76354889
51Phagosome_Homo sapiens_hsa041450.75623980
52African trypanosomiasis_Homo sapiens_hsa051430.73625891
53Pertussis_Homo sapiens_hsa051330.70072213
54Viral carcinogenesis_Homo sapiens_hsa052030.68030252
55Rheumatoid arthritis_Homo sapiens_hsa053230.65959303
56Prolactin signaling pathway_Homo sapiens_hsa049170.65554587
57Chronic myeloid leukemia_Homo sapiens_hsa052200.64182849
58Renal cell carcinoma_Homo sapiens_hsa052110.63447044
59Legionellosis_Homo sapiens_hsa051340.61802734
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61238354
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60641027
62Salmonella infection_Homo sapiens_hsa051320.60394439
63FoxO signaling pathway_Homo sapiens_hsa040680.60096971
64Choline metabolism in cancer_Homo sapiens_hsa052310.59637907
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.58282110
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57747697
67Regulation of autophagy_Homo sapiens_hsa041400.56263483
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.56196975
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54318998
70Colorectal cancer_Homo sapiens_hsa052100.51903064
71mTOR signaling pathway_Homo sapiens_hsa041500.51086552
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50070785
73Renin secretion_Homo sapiens_hsa049240.44975621
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.44520288
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43680761
76MAPK signaling pathway_Homo sapiens_hsa040100.42099521
77Insulin resistance_Homo sapiens_hsa049310.41769507
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40239687
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39944027
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39797700
81HIF-1 signaling pathway_Homo sapiens_hsa040660.39758297
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39569658
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37364519
84GnRH signaling pathway_Homo sapiens_hsa049120.35968852
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35221952
86Rap1 signaling pathway_Homo sapiens_hsa040150.34602556
87Ras signaling pathway_Homo sapiens_hsa040140.34192112
88Endometrial cancer_Homo sapiens_hsa052130.33062396
89Inositol phosphate metabolism_Homo sapiens_hsa005620.33002509
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.32641719
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32021104
92Oxytocin signaling pathway_Homo sapiens_hsa049210.29538365
93Prostate cancer_Homo sapiens_hsa052150.29205852
94Notch signaling pathway_Homo sapiens_hsa043300.28874018
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27006109
96Collecting duct acid secretion_Homo sapiens_hsa049660.25867458
97Lysosome_Homo sapiens_hsa041420.25176880
98cAMP signaling pathway_Homo sapiens_hsa040240.24152054
99ErbB signaling pathway_Homo sapiens_hsa040120.24092458
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23974077

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