KIR3DL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of T cell mediated immunity (GO:0002710)9.06440534
2relaxation of smooth muscle (GO:0044557)8.05064307
3negative regulation of cAMP-mediated signaling (GO:0043951)7.96109835
4negative regulation of cardiac muscle hypertrophy (GO:0010614)7.87058996
5desmosome organization (GO:0002934)7.72985658
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.48438029
7negative regulation of cell killing (GO:0031342)7.48438029
8glial cell proliferation (GO:0014009)7.26794758
9negative regulation of muscle hypertrophy (GO:0014741)7.03646486
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.88376880
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.82953376
12negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)6.71074625
13regulation of hypersensitivity (GO:0002883)6.66867035
14positive regulation of T cell cytokine production (GO:0002726)6.61960591
15negative regulation of lipase activity (GO:0060192)6.50196176
16positive regulation of gamma-delta T cell activation (GO:0046645)6.38276738
17negative regulation of interleukin-2 production (GO:0032703)6.36082400
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.31687913
19cellular response to interleukin-15 (GO:0071350)6.19506067
20regulation of T cell chemotaxis (GO:0010819)6.14114466
21positive regulation of T cell chemotaxis (GO:0010820)6.14114466
22regulation of B cell receptor signaling pathway (GO:0050855)6.07765182
23relaxation of cardiac muscle (GO:0055119)6.02700270
24antigen processing and presentation of endogenous antigen (GO:0019883)5.94654142
25positive regulation of microtubule polymerization (GO:0031116)5.88673083
26response to interleukin-15 (GO:0070672)5.88499121
27activated T cell proliferation (GO:0050798)5.77357014
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.73023577
29dichotomous subdivision of an epithelial terminal unit (GO:0060600)5.63440246
30positive thymic T cell selection (GO:0045059)5.50518451
31positive regulation of T cell mediated cytotoxicity (GO:0001916)5.44101195
32leukocyte aggregation (GO:0070486)5.39723699
33negative regulation of lymphocyte mediated immunity (GO:0002707)5.32571369
34interferon-gamma production (GO:0032609)5.29307441
35positive regulation of alpha-beta T cell proliferation (GO:0046641)5.29085198
36positive regulation of transforming growth factor beta production (GO:0071636)5.21725114
37neutrophil activation involved in immune response (GO:0002283)5.13362679
38termination of G-protein coupled receptor signaling pathway (GO:0038032)5.06061306
39regulation of T cell tolerance induction (GO:0002664)4.92725901
40positive regulation of type 2 immune response (GO:0002830)4.88266153
41negative regulation of smooth muscle contraction (GO:0045986)4.85561014
42regulation of gamma-delta T cell activation (GO:0046643)4.66323078
43mammary gland alveolus development (GO:0060749)4.65617415
44regulation of gamma-delta T cell differentiation (GO:0045586)4.61113698
45termination of signal transduction (GO:0023021)4.59653854
46regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.58281302
47regulation of natural killer cell mediated immunity (GO:0002715)4.58281302
48regulation of acute inflammatory response to antigenic stimulus (GO:0002864)4.53452618
49positive regulation of interleukin-10 production (GO:0032733)4.47724544
50regulation of alpha-beta T cell proliferation (GO:0046640)4.45254280
51macrophage activation involved in immune response (GO:0002281)4.41966682
52negative T cell selection (GO:0043383)4.41450061
53negative thymic T cell selection (GO:0045060)4.41226529
54negative regulation of transcription by competitive promoter binding (GO:0010944)4.38293972
55regulation of T cell cytokine production (GO:0002724)4.37776884
56positive regulation of T-helper 1 type immune response (GO:0002827)4.36321703
57regulation of T cell mediated cytotoxicity (GO:0001914)4.34327464
58regulation of T cell receptor signaling pathway (GO:0050856)4.28136851
59negative regulation of interferon-gamma production (GO:0032689)4.24173578
60positive regulation by symbiont of host defense response (GO:0052509)4.22558627
61modulation by symbiont of host defense response (GO:0052031)4.22558627
62modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.22558627
63modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.22558627
64positive regulation by organism of defense response of other organism involved in symbiotic interact4.22558627
65modulation by symbiont of host immune response (GO:0052553)4.22558627
66detection of bacterium (GO:0016045)4.22487850
67lymphocyte chemotaxis (GO:0048247)4.21616141
68keratinocyte development (GO:0003334)4.20883069
69detection of other organism (GO:0098543)4.19056031
70neutrophil activation (GO:0042119)4.15302162
71T cell migration (GO:0072678)4.13471307
72cellular extravasation (GO:0045123)4.08144879
73thymic T cell selection (GO:0045061)4.00925046
74positive regulation of tolerance induction (GO:0002645)3.99786976
75B cell receptor signaling pathway (GO:0050853)3.97637069
76positive T cell selection (GO:0043368)3.97563766
77regulation of B cell differentiation (GO:0045577)3.96855296
78positive regulation of microtubule polymerization or depolymerization (GO:0031112)3.95760403
79granulocyte activation (GO:0036230)3.92574673
80negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.86586684
81regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.81535042
82antigen processing and presentation via MHC class Ib (GO:0002475)3.78311466
83regulation of lymphocyte chemotaxis (GO:1901623)3.77606745
84positive regulation of natural killer cell mediated immunity (GO:0002717)3.73928469
85positive regulation of granulocyte differentiation (GO:0030854)3.72360686
86myeloid cell activation involved in immune response (GO:0002275)3.69673105
87keratinocyte proliferation (GO:0043616)3.69603138
88negative regulation of cytokine production involved in immune response (GO:0002719)3.68019095
89leukocyte migration involved in inflammatory response (GO:0002523)3.63015688
90microglial cell activation (GO:0001774)3.61456655
91mammary gland epithelial cell proliferation (GO:0033598)3.61454602
92regulation of axon regeneration (GO:0048679)3.60247709
93regulation of neuron projection regeneration (GO:0070570)3.60247709
94positive regulation of immunoglobulin mediated immune response (GO:0002891)3.60122085
95positive regulation of B cell mediated immunity (GO:0002714)3.60122085
96positive regulation of interleukin-4 production (GO:0032753)3.59889070
97regulation of leukocyte mediated cytotoxicity (GO:0001910)3.58242171
98establishment of skin barrier (GO:0061436)3.55722593
99cornea development in camera-type eye (GO:0061303)3.55570740
100positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)3.54404826
101relaxation of muscle (GO:0090075)3.53900638
102type I interferon signaling pathway (GO:0060337)3.53837818
103cellular response to type I interferon (GO:0071357)3.53837818
104response to type I interferon (GO:0034340)3.52579033
105response to UV-B (GO:0010224)3.49885092
106negative regulation of interleukin-12 production (GO:0032695)3.48914877
107mast cell activation (GO:0045576)3.48714682
108regulation of tolerance induction (GO:0002643)3.45226773
109negative regulation of leukocyte mediated immunity (GO:0002704)3.45168926
110leukocyte degranulation (GO:0043299)3.42290891
111regulation of transforming growth factor beta production (GO:0071634)3.41529276
112immunoglobulin mediated immune response (GO:0016064)3.40036608
113T cell receptor signaling pathway (GO:0050852)3.39763543
114embryonic body morphogenesis (GO:0010172)3.38797647
115positive regulation of T cell migration (GO:2000406)3.38755653
116negative regulation of alpha-beta T cell activation (GO:0046636)3.38093037
117positive regulation of mast cell activation (GO:0033005)3.37112029
118regulation of water loss via skin (GO:0033561)3.34016147
119positive regulation of hair cycle (GO:0042635)3.32301966
120positive regulation of hair follicle development (GO:0051798)3.32301966
121respiratory burst (GO:0045730)3.29547165
122positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.29445732
123positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.27708559
124negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744)3.27261492
125negative regulation of muscle contraction (GO:0045932)3.26759559
126regulation of cell killing (GO:0031341)3.25495106
127regulation of receptor recycling (GO:0001919)3.24045376
128regulation of interleukin-10 production (GO:0032653)3.23843938
129detection of external biotic stimulus (GO:0098581)3.23198256
130positive regulation of B cell differentiation (GO:0045579)3.21687517
131positive regulation of granulocyte chemotaxis (GO:0071624)3.19149787
132cellular defense response (GO:0006968)3.18071639
133positive regulation of neutrophil chemotaxis (GO:0090023)3.17957736
134positive regulation of neutrophil migration (GO:1902624)3.17957736
135cellular response to zinc ion (GO:0071294)3.17320080
136negative regulation of adaptive immune response (GO:0002820)3.16417253
137positive regulation of odontogenesis (GO:0042482)3.15985390
138regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.15972062
139positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.15857398
140positive regulation of cell killing (GO:0031343)3.15204991
141response to peptidoglycan (GO:0032494)3.13119223
142regulation of mast cell degranulation (GO:0043304)3.11437572
143basement membrane organization (GO:0071711)3.10166886
144regulation of regulatory T cell differentiation (GO:0045589)3.09936189
145regulation of T-helper 1 type immune response (GO:0002825)3.09826084
146positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.09315521
147positive regulation of calcium-mediated signaling (GO:0050850)3.07299049
148response to host immune response (GO:0052572)3.06750802
149response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.06750802
150negative regulation of phagocytosis (GO:0050765)3.04734207
151eyelid development in camera-type eye (GO:0061029)3.04507125
152cytidine deamination (GO:0009972)3.04374871
153cytidine metabolic process (GO:0046087)3.04374871
154cytidine catabolic process (GO:0006216)3.04374871
155regulation of mast cell activation (GO:0033003)2.97985811
156detection of biotic stimulus (GO:0009595)2.95498605
157T cell selection (GO:0045058)2.94519407
158lymphocyte migration (GO:0072676)2.94020734
159positive regulation of isotype switching (GO:0045830)2.93998034
160positive regulation of cytokine production involved in immune response (GO:0002720)2.93943145
161negative regulation of innate immune response (GO:0045824)2.93303262
162dendritic cell chemotaxis (GO:0002407)2.91952906
163positive regulation of interleukin-8 secretion (GO:2000484)2.90573342
164pyrimidine ribonucleoside catabolic process (GO:0046133)2.90289024
165centrosome localization (GO:0051642)2.90185385
166regulation of mast cell activation involved in immune response (GO:0033006)2.90165903
167T cell proliferation (GO:0042098)2.89889637
168macrophage activation (GO:0042116)2.89611889
169positive regulation of lymphocyte migration (GO:2000403)2.89521865
170interferon-gamma-mediated signaling pathway (GO:0060333)2.89513336
171regulation of T cell migration (GO:2000404)2.87971125
172response to host defenses (GO:0052200)2.87835267
173response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.87835267
174positive regulation of T cell differentiation in thymus (GO:0033089)2.82211541
175negative regulation of production of molecular mediator of immune response (GO:0002701)2.77962806
176signal complex assembly (GO:0007172)2.77198542
177positive regulation of immunoglobulin production (GO:0002639)2.75503026
178antigen receptor-mediated signaling pathway (GO:0050851)2.75078711
179body morphogenesis (GO:0010171)2.74085747

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.69244511
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.54929497
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.32070879
4* CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human5.15379090
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.11266833
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.03279918
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.81423791
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.69153116
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.60559898
10VDR_22108803_ChIP-Seq_LS180_Human3.23965571
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.16064231
12MYB_26560356_Chip-Seq_TH2_Human2.88713287
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.79533857
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.75031627
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.62784748
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.60392540
17MAF_26560356_Chip-Seq_TH1_Human2.58239504
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.52868557
19SPI1_23547873_ChIP-Seq_NB4_Human2.45478934
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.44822642
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.43094946
22UTX_26944678_Chip-Seq_JUKART_Human2.38473659
23MYB_26560356_Chip-Seq_TH1_Human2.36933470
24BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.35309662
25SPI1_23127762_ChIP-Seq_K562_Human2.34696131
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26471124
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.21482797
28MYC_22102868_ChIP-Seq_BL_Human2.20948791
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.18111332
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.11888710
31VDR_24763502_ChIP-Seq_THP-1_Human2.11743929
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.08814153
33VDR_21846776_ChIP-Seq_THP-1_Human2.07545383
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.98375716
35MAF_26560356_Chip-Seq_TH2_Human1.91956299
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86892014
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82684354
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.82559363
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.76384592
40ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.75786551
41TCF7_22412390_ChIP-Seq_EML_Mouse1.71044570
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.69628588
43* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.67614069
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63920483
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.63478109
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.60146133
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60121085
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59327132
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.57173039
50KDM2B_26808549_Chip-Seq_DND41_Human1.56945564
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.56281302
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55890334
53RXR_22108803_ChIP-Seq_LS180_Human1.52857952
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50657642
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.47770271
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45957760
57VDR_24787735_ChIP-Seq_THP-1_Human1.45026281
58AHR_22903824_ChIP-Seq_MCF-7_Human1.43666468
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40789070
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38921075
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38921075
62Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.38920611
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38374277
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.37889352
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.37209202
66EZH2_27304074_Chip-Seq_ESCs_Mouse1.34925423
67RUNX_20019798_ChIP-Seq_JUKART_Human1.34894469
68TAF15_26573619_Chip-Seq_HEK293_Human1.34157528
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34115587
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32955587
71SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32923178
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31329377
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31030643
74RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.29876730
75SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29524166
76TCF4_18268006_ChIP-ChIP_LS174T_Human1.28514333
77FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28245774
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26982235
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26144041
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24838020
81GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23547851
82GATA1_22025678_ChIP-Seq_K562_Human1.23047588
83SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22994719
84CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22183118
85* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20651992
86* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20651992
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.19463275
88JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19148432
89SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19007079
90GATA1_19941826_ChIP-Seq_K562_Human1.18920223
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18019983
92SOX2_20726797_ChIP-Seq_SW620_Human1.16356338
93MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15775763
94SCL_19346495_ChIP-Seq_HPC-7_Human1.15758603
95PU_27001747_Chip-Seq_BMDM_Mouse1.14818882
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.14310624
97KDM2B_26808549_Chip-Seq_JURKAT_Human1.13958826
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.13450778
99SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11631652
100CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10991883
101ZNF263_19887448_ChIP-Seq_K562_Human1.09757006
102NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08584208
103GATA2_21666600_ChIP-Seq_HMVEC_Human1.08521559
104PKCTHETA_26484144_Chip-Seq_BREAST_Human1.08412529
105JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08311475
106PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08223802
107PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07979120
108GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07584900
109EED_16625203_ChIP-ChIP_MESCs_Mouse1.07578938
110LXR_22158963_ChIP-Seq_LIVER_Mouse1.07562284
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06120496
112FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05631102
113GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05518450
114BCAT_22108803_ChIP-Seq_LS180_Human1.05444803
115EZH2_27294783_Chip-Seq_ESCs_Mouse1.05285708
116CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05113955
117RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04688862
118PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04524266
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04158710
120TP53_18474530_ChIP-ChIP_U2OS_Human1.03964532
121PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03877466
122FOXO3_23340844_ChIP-Seq_DLD1_Human1.02977322
123ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02316413
124ELK3_25401928_ChIP-Seq_HUVEC_Human1.00142028
125CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99931883
126GATA3_24758297_ChIP-Seq_MCF-7_Human0.99767315
127SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98387646
128CJUN_26792858_Chip-Seq_BT549_Human0.97879001
129MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96191949
130DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95648941
131P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93341421
132RXR_22158963_ChIP-Seq_LIVER_Mouse0.93246559
133RNF2_27304074_Chip-Seq_ESCs_Mouse0.92950684
134TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91662731
135CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91618635
136ETV1_20927104_ChIP-Seq_GIST48_Human0.91016302
137BCL6_27268052_Chip-Seq_Bcells_Human0.90538224
138GATA2_19941826_ChIP-Seq_K562_Human0.90492032
139STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90292643
140THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90200569
141EZH2_27294783_Chip-Seq_NPCs_Mouse0.89734895
142RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89405733
143SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89072751
144NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88652782
145NOTCH1_21737748_ChIP-Seq_TLL_Human0.88409894
146NANOG_18555785_Chip-Seq_ESCs_Mouse0.87659528
147RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87451823
148ESR2_21235772_ChIP-Seq_MCF-7_Human0.87042081
149HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.86205482
150GATA3_27048872_Chip-Seq_THYMUS_Human0.85665337
151CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84554821
152PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84140565
153PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83383495
154GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.83135893
155GATA3_26560356_Chip-Seq_TH2_Human0.82131307
156BCOR_27268052_Chip-Seq_Bcells_Human0.81850401
157GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.81548478
158TP63_23658742_ChIP-Seq_EP156T_Human0.80142760
159EGR1_23403033_ChIP-Seq_LIVER_Mouse0.80021484
160KLF5_20875108_ChIP-Seq_MESCs_Mouse0.79322133
161TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.78675055
162GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78614739
163CDX2_20551321_ChIP-Seq_CACO-2_Human0.78338873
164CIITA_25753668_ChIP-Seq_RAJI_Human0.78083579
165TCF4_22108803_ChIP-Seq_LS180_Human0.77756592
166CRX_20693478_ChIP-Seq_RETINA_Mouse0.77133776
167CBX2_22325352_ChIP-Seq_293T-Rex_Human0.77092477
168TP53_16413492_ChIP-PET_HCT116_Human0.77053621
169GATA1_19941827_ChIP-Seq_MEL86_Mouse0.76676555
170GATA3_26560356_Chip-Seq_TH1_Human0.75634111
171RBPJ_21746931_ChIP-Seq_IB4_Human0.75417639
172FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75338711
173SMRT_27268052_Chip-Seq_Bcells_Human0.75081659
174RING1B_27294783_Chip-Seq_ESCs_Mouse0.74892588
175ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.74718657
176ESR1_21235772_ChIP-Seq_MCF-7_Human0.74647424
177HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.74221272
178KDM2B_26808549_Chip-Seq_K562_Human0.73822510
179WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.73805308
180GATA6_21074721_ChIP-Seq_CACO-2_Human0.73751996
181STAT6_21828071_ChIP-Seq_BEAS2B_Human0.73333560
182STAT4_19710469_ChIP-ChIP_TH1__Mouse0.73021671
183CMYC_18555785_Chip-Seq_ESCs_Mouse0.72963735

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.18273604
2MP0005671_abnormal_response_to4.59416653
3MP0004381_abnormal_hair_follicle4.28868537
4MP0001835_abnormal_antigen_presentation4.07463930
5MP0003436_decreased_susceptibility_to3.93716030
6MP0002796_impaired_skin_barrier3.83526838
7MP0006082_CNS_inflammation3.81289022
8MP0002098_abnormal_vibrissa_morphology3.65396443
9MP0003941_abnormal_skin_development3.52807646
10MP0003705_abnormal_hypodermis_morpholog3.36507155
11MP0002009_preneoplasia2.92760604
12MP0003950_abnormal_plasma_membrane2.78693526
13MP0002419_abnormal_innate_immunity2.77489385
14MP0004947_skin_inflammation2.69887223
15MP0000579_abnormal_nail_morphology2.68954855
16MP0000685_abnormal_immune_system2.60924702
17MP0005464_abnormal_platelet_physiology2.53021443
18MP0008961_abnormal_basal_metabolism2.44537544
19MP0009333_abnormal_splenocyte_physiolog2.42866695
20MP0003183_abnormal_peptide_metabolism2.36739625
21MP0003959_abnormal_lean_body2.36034535
22MP0002398_abnormal_bone_marrow2.33189584
23MP0002405_respiratory_system_inflammati2.31369611
24MP0000627_abnormal_mammary_gland2.27829315
25MP0004185_abnormal_adipocyte_glucose2.14343730
26MP0003300_gastrointestinal_ulcer2.14136762
27MP0000716_abnormal_immune_system2.12720924
28MP0001881_abnormal_mammary_gland2.05134168
29MP0005085_abnormal_gallbladder_physiolo1.99843340
30MP0003303_peritoneal_inflammation1.99010906
31MP0010155_abnormal_intestine_physiology1.92658762
32MP0002060_abnormal_skin_morphology1.91823350
33MP0005501_abnormal_skin_physiology1.88752544
34MP0001533_abnormal_skeleton_physiology1.88134600
35MP0002132_abnormal_respiratory_system1.88131202
36MP0001216_abnormal_epidermal_layer1.86364477
37MP0000689_abnormal_spleen_morphology1.85363606
38MP0002837_dystrophic_cardiac_calcinosis1.82521854
39MP0003453_abnormal_keratinocyte_physiol1.80854895
40MP0001845_abnormal_inflammatory_respons1.74414248
41MP0003866_abnormal_defecation1.74027459
42MP0005408_hypopigmentation1.68329974
43MP0002429_abnormal_blood_cell1.67611379
44MP0002006_tumorigenesis1.64066198
45MP0002277_abnormal_respiratory_mucosa1.63257749
46MP0001873_stomach_inflammation1.59506464
47MP0005075_abnormal_melanosome_morpholog1.56781155
48MP0003566_abnormal_cell_adhesion1.52706049
49MP0001661_extended_life_span1.52404121
50MP0003828_pulmonary_edema1.50630258
51MP0004859_abnormal_synaptic_plasticity1.50342218
52MP0003172_abnormal_lysosome_physiology1.49845790
53MP0008875_abnormal_xenobiotic_pharmacok1.48169223
54MP0003252_abnormal_bile_duct1.47414741
55MP0001853_heart_inflammation1.44300910
56MP0000427_abnormal_hair_cycle1.43970614
57MP0002396_abnormal_hematopoietic_system1.41774435
58MP0000377_abnormal_hair_follicle1.39794058
59MP0003936_abnormal_reproductive_system1.39026266
60MP0006054_spinal_hemorrhage1.38556923
61MP0003724_increased_susceptibility_to1.37196590
62MP0004510_myositis1.37056431
63MP0000858_altered_metastatic_potential1.36509305
64MP0004883_abnormal_blood_vessel1.36293533
65MP0008469_abnormal_protein_level1.35387086
66MP0004858_abnormal_nervous_system1.35079756
67MP0000762_abnormal_tongue_morphology1.34284653
68MP0000367_abnormal_coat/_hair1.34155031
69MP0005365_abnormal_bile_salt1.30267961
70MP0002148_abnormal_hypersensitivity_rea1.24348586
71MP0000465_gastrointestinal_hemorrhage1.23583062
72MP0010352_gastrointestinal_tract_polyps1.23015902
73MP0003763_abnormal_thymus_physiology1.20769083
74MP0003191_abnormal_cellular_cholesterol1.20456241
75MP0002998_abnormal_bone_remodeling1.18010068
76MP0001851_eye_inflammation1.17562290
77MP0010771_integument_phenotype1.17236976
78MP0005310_abnormal_salivary_gland1.16775398
79MP0004270_analgesia1.16325872
80MP0001501_abnormal_sleep_pattern1.15753350
81MP0003690_abnormal_glial_cell1.12995820
82MP0009785_altered_susceptibility_to1.09736870
83MP0005647_abnormal_sex_gland1.09443691
84MP0003045_fibrosis1.05662903
85MP0002896_abnormal_bone_mineralization1.05199316
86MP0000751_myopathy1.03655689
87MP0004233_abnormal_muscle_weight1.02257710
88MP0000490_abnormal_crypts_of1.00872813
89MP0001340_abnormal_eyelid_morphology1.00592954
90MP0001800_abnormal_humoral_immune1.00150910
91MP0002166_altered_tumor_susceptibility0.97935009
92MP0001819_abnormal_immune_cell0.97375615
93MP0003938_abnormal_ear_development0.97026246
94MP0005000_abnormal_immune_tolerance0.94979905
95MP0005451_abnormal_body_composition0.94764936
96MP0009763_increased_sensitivity_to0.94731465
97MP0010678_abnormal_skin_adnexa0.94364919
98MP0001790_abnormal_immune_system0.93768897
99MP0005387_immune_system_phenotype0.93768897
100MP0005025_abnormal_response_to0.93281418
101MP0008260_abnormal_autophagy0.93060205
102MP0005166_decreased_susceptibility_to0.91342640
103MP0004130_abnormal_muscle_cell0.90984079
104MP0000609_abnormal_liver_physiology0.88096779
105MP0002723_abnormal_immune_serum0.88057254
106MP0002722_abnormal_immune_system0.87688305
107MP0005360_urolithiasis0.87656819
108MP0002139_abnormal_hepatobiliary_system0.87620269
109MP0002254_reproductive_system_inflammat0.87226223
110MP0001765_abnormal_ion_homeostasis0.87063410
111MP0003448_altered_tumor_morphology0.86997207
112MP0001663_abnormal_digestive_system0.86828552
113MP0005275_abnormal_skin_tensile0.86408011
114MP0003635_abnormal_synaptic_transmissio0.86222730
115MP0000647_abnormal_sebaceous_gland0.86191922
116MP0009931_abnormal_skin_appearance0.86140541
117MP0004019_abnormal_vitamin_homeostasis0.85347338
118MP0003633_abnormal_nervous_system0.84108912
119MP0005164_abnormal_response_to0.83963793
120MP0001986_abnormal_taste_sensitivity0.83267679
121MP0002332_abnormal_exercise_endurance0.81580926
122MP0000467_abnormal_esophagus_morphology0.81470916
123MP0009278_abnormal_bone_marrow0.81358662
124MP0001849_ear_inflammation0.81109515
125MP0002877_abnormal_melanocyte_morpholog0.79145948
126MP0002933_joint_inflammation0.77488986
127MP0005165_increased_susceptibility_to0.77322909
128MP0000015_abnormal_ear_pigmentation0.76161960
129MP0000703_abnormal_thymus_morphology0.75387848
130MP0004142_abnormal_muscle_tone0.74591710
131MP0002420_abnormal_adaptive_immunity0.73689787
132MP0001191_abnormal_skin_condition0.73304267
133MP0000383_abnormal_hair_follicle0.71269736
134MP0000470_abnormal_stomach_morphology0.71166599
135MP0003880_abnormal_central_pattern0.69662988
136MP0005390_skeleton_phenotype0.69139225
137MP0001666_abnormal_nutrient_absorption0.69130831
138MP0002136_abnormal_kidney_physiology0.68946440
139MP0009764_decreased_sensitivity_to0.67404141
140MP0002452_abnormal_antigen_presenting0.67322774
141MP0002970_abnormal_white_adipose0.66367468
142MP0000537_abnormal_urethra_morphology0.65760762
143MP0005397_hematopoietic_system_phenotyp0.65119020
144MP0001545_abnormal_hematopoietic_system0.65119020
145MP0004808_abnormal_hematopoietic_stem0.65014052
146MP0003075_altered_response_to0.65009467
147MP0002019_abnormal_tumor_incidence0.64963794
148MP0002572_abnormal_emotion/affect_behav0.64286781
149MP0002693_abnormal_pancreas_physiology0.61697962
150MP0000249_abnormal_blood_vessel0.61079732
151MP0005083_abnormal_biliary_tract0.60311582
152MP0009765_abnormal_xenobiotic_induced0.58972503
153MP0003795_abnormal_bone_structure0.54267022
154MP0005058_abnormal_lysosome_morphology0.52400927
155MP0008004_abnormal_stomach_pH0.51826215
156MP0003638_abnormal_response/metabolism_0.50458822
157MP0008873_increased_physiological_sensi0.49771878
158MP0000920_abnormal_myelination0.48109901
159MP0000343_altered_response_to0.47226704
160MP0009115_abnormal_fat_cell0.45611414
161MP0000569_abnormal_digit_pigmentation0.45170256
162MP0003943_abnormal_hepatobiliary_system0.44846002
163MP0005381_digestive/alimentary_phenotyp0.44204421
164MP0005319_abnormal_enzyme/_coenzyme0.42797264
165MP0008874_decreased_physiological_sensi0.41546140
166MP0005376_homeostasis/metabolism_phenot0.40989889

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune hemolytic anemia (HP:0001890)9.88727943
2Lip pit (HP:0100267)6.61958213
3Natal tooth (HP:0000695)6.56712152
4Parakeratosis (HP:0001036)6.24884457
5T lymphocytopenia (HP:0005403)5.54804757
6Myositis (HP:0100614)5.26142653
7Recurrent abscess formation (HP:0002722)5.22867746
8Abnormality of T cell number (HP:0011839)5.20671539
9Epidermoid cyst (HP:0200040)5.15268234
10Abnormality of macrophages (HP:0004311)5.08889373
11Recurrent bacterial skin infections (HP:0005406)5.05243079
12Abnormal delayed hypersensitivity skin test (HP:0002963)4.74755126
13Abnormality of the nasal septum (HP:0000419)4.57309087
14Advanced eruption of teeth (HP:0006288)4.45480789
15Encephalitis (HP:0002383)4.42845811
16Morphological abnormality of the middle ear (HP:0008609)4.33885425
17Congenital, generalized hypertrichosis (HP:0004540)4.30717988
18Abnormality of nail color (HP:0100643)4.17117162
19Recurrent fungal infections (HP:0002841)4.14934443
20Spontaneous hematomas (HP:0007420)4.10186915
21Meningitis (HP:0001287)4.09128423
22Abnormality of T cells (HP:0002843)4.03250656
23Aplasia cutis congenita (HP:0001057)3.96403343
24Prolonged bleeding time (HP:0003010)3.81834783
25Obstructive lung disease (HP:0006536)3.80274888
26Chronic obstructive pulmonary disease (HP:0006510)3.80274888
27Gastrointestinal infarctions (HP:0005244)3.80123244
28Dry hair (HP:0011359)3.78635005
29Recurrent gram-negative bacterial infections (HP:0005420)3.73596680
30Chronic mucocutaneous candidiasis (HP:0002728)3.71921908
31Recurrent cutaneous fungal infections (HP:0011370)3.71921908
32Renal cortical cysts (HP:0000803)3.68110935
33Palmoplantar hyperkeratosis (HP:0000972)3.61813425
34Recurrent skin infections (HP:0001581)3.59901453
35Increased IgM level (HP:0003496)3.58986122
36Palmar hyperkeratosis (HP:0010765)3.52859105
37Hypochromic microcytic anemia (HP:0004840)3.48996506
38Nasolacrimal duct obstruction (HP:0000579)3.46776256
39White forelock (HP:0002211)3.45538761
40Vasculitis (HP:0002633)3.39543291
41Abnormal number of erythroid precursors (HP:0012131)3.38171165
42Keratoconjunctivitis sicca (HP:0001097)3.34238118
43Hypotrichosis (HP:0001006)3.32241492
44Gingival bleeding (HP:0000225)3.32028112
45Abnormality of cells of the erythroid lineage (HP:0012130)3.29464784
46Chest pain (HP:0100749)3.27954019
47Panhypogammaglobulinemia (HP:0003139)3.26128715
48Pustule (HP:0200039)3.25831250
49Stomatitis (HP:0010280)3.22161088
50Hypochromic anemia (HP:0001931)3.21896628
51Gingivitis (HP:0000230)3.19537804
52Recurrent viral infections (HP:0004429)3.18712174
53Increased IgE level (HP:0003212)3.17944519
54Granulocytopenia (HP:0001913)3.17891683
55Leukocytosis (HP:0001974)3.17630418
56Pulmonary infiltrates (HP:0002113)3.17223145
57Abnormality of secondary sexual hair (HP:0009888)3.16553676
58Abnormality of the axillary hair (HP:0100134)3.16553676
59Inflammation of the large intestine (HP:0002037)3.15942820
60Abnormality of the distal phalanges of the toes (HP:0010182)3.14548555
61Epistaxis (HP:0000421)3.13637269
62Keratoconjunctivitis (HP:0001096)3.12457448
63Sparse scalp hair (HP:0002209)3.06694124
64Plantar hyperkeratosis (HP:0007556)3.03912037
65Gastrointestinal inflammation (HP:0004386)3.03804311
66Premature rupture of membranes (HP:0001788)3.03453771
67Abnormality of the lacrimal duct (HP:0011481)3.03226489
68Abnormality of the nasolacrimal system (HP:0000614)3.02733474
69Eosinophilia (HP:0001880)2.97551340
70Right ventricular cardiomyopathy (HP:0011663)2.97437888
71Joint swelling (HP:0001386)2.97215389
72Recurrent bronchitis (HP:0002837)2.96219454
73Conjugated hyperbilirubinemia (HP:0002908)2.95875517
74Urticaria (HP:0001025)2.94384736
75Abnormality of T cell physiology (HP:0011840)2.91423067
76Submucous cleft hard palate (HP:0000176)2.90090501
77Arterial thrombosis (HP:0004420)2.82211416
78Abnormality of aromatic amino acid family metabolism (HP:0004338)2.80735606
79Patchy hypopigmentation of hair (HP:0011365)2.76293026
80Anorexia (HP:0002039)2.74042860
81Abnormality of eosinophils (HP:0001879)2.72650816
82Episodic fever (HP:0001954)2.71177916
83Petechiae (HP:0000967)2.71142416
84Osteolytic defects of the phalanges of the hand (HP:0009771)2.67127774
85Osteolytic defects of the hand bones (HP:0009699)2.67127774
86Sparse eyelashes (HP:0000653)2.65426658
87Hemiplegia (HP:0002301)2.63240982
88Hemoptysis (HP:0002105)2.62536533
89Pulmonary embolism (HP:0002204)2.60113462
90Generalized hypopigmentation of hair (HP:0011358)2.56246373
91IgG deficiency (HP:0004315)2.53538524
92Severe combined immunodeficiency (HP:0004430)2.53054381
93Intrahepatic cholestasis (HP:0001406)2.51303812
94Prolonged partial thromboplastin time (HP:0003645)2.50565019
95Abnormality of cells of the lymphoid lineage (HP:0012140)2.47347490
96Fair hair (HP:0002286)2.45443169
97Muscle fiber atrophy (HP:0100295)2.39831240
98Hypergammaglobulinemia (HP:0010702)2.39451874
99Agammaglobulinemia (HP:0004432)2.37909270
100Purpura (HP:0000979)2.37877488
101Megalencephaly (HP:0001355)2.36857943
102Anophthalmia (HP:0000528)2.36671916
103Woolly hair (HP:0002224)2.32422079
104Microcytic anemia (HP:0001935)2.31172350
105Elevated erythrocyte sedimentation rate (HP:0003565)2.30628628
106Asplenia (HP:0001746)2.29565978
107Type 2 muscle fiber atrophy (HP:0003554)2.28444546
108IgM deficiency (HP:0002850)2.28290032
109Reduced subcutaneous adipose tissue (HP:0003758)2.25989481
110Nasal polyposis (HP:0100582)2.25567893
111Cellulitis (HP:0100658)2.24496692
112Colitis (HP:0002583)2.23897420
113Increased serum ferritin (HP:0003281)2.23812609
114Limb hypertonia (HP:0002509)2.21872410
115Angiofibromas (HP:0010615)2.20582056
116Adenoma sebaceum (HP:0009720)2.20582056
117Abnormal platelet volume (HP:0011876)2.20495757
118Autoimmune thrombocytopenia (HP:0001973)2.17106939
119Popliteal pterygium (HP:0009756)2.15836616
120Chronic otitis media (HP:0000389)2.14624305
121Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.13569727
122Hydroxyprolinuria (HP:0003080)2.12737399
123Abnormality of proline metabolism (HP:0010907)2.12737399
124Abnormality of the pleura (HP:0002103)2.10118788
125Abnormality of the fingertips (HP:0001211)2.10106283
126Short nail (HP:0001799)2.09284339
127Abnormality of binocular vision (HP:0011514)2.09069807
128Diplopia (HP:0000651)2.09069807
129Chronic diarrhea (HP:0002028)2.08081616
130Abnormality of iron homeostasis (HP:0011031)2.07888604
131Weak cry (HP:0001612)2.07410863
132Gangrene (HP:0100758)2.06540376
133Premature graying of hair (HP:0002216)2.06028638
134Acute hepatic failure (HP:0006554)2.05969091
135Aplasia/Hypoplasia of the spleen (HP:0010451)2.05405132
136Fatigable weakness (HP:0003473)2.04958255
137Abnormality of the neuromuscular junction (HP:0003398)2.04958255
138Verrucae (HP:0200043)2.04607004
139Papilloma (HP:0012740)2.04607004
140Wide intermamillary distance (HP:0006610)2.04567127
141Hyperlipoproteinemia (HP:0010980)2.04377204
142Sepsis (HP:0100806)2.03153107
143Hoarse voice (HP:0001609)2.00104854
144Nonprogressive disorder (HP:0003680)1.99784210
145Glomerulopathy (HP:0100820)1.99766270
146Slow saccadic eye movements (HP:0000514)1.99531977
147Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.98476448
148Orchitis (HP:0100796)1.96982559
149Combined immunodeficiency (HP:0005387)1.95731579
150Amaurosis fugax (HP:0100576)1.94448223
151Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.92352050
152Vertigo (HP:0002321)1.92090403
153Ventricular tachycardia (HP:0004756)1.91218417
154Hypoplasia of the thymus (HP:0000778)1.89499340
155Viral hepatitis (HP:0006562)1.88870594
156Acne (HP:0001061)1.87574964
157Lymphoma (HP:0002665)1.87366221
158Supernumerary nipples (HP:0002558)1.86790817
159Preauricular pit (HP:0004467)1.86248832
160Periauricular skin pits (HP:0100277)1.86248832
161Papilledema (HP:0001085)1.84717932
162Aplasia/Hypoplasia of the thymus (HP:0010515)1.84448459
163Acanthosis nigricans (HP:0000956)1.83006417
164Obstructive sleep apnea (HP:0002870)1.82406951
165Hyperglycemia (HP:0003074)1.81296820
166Distal lower limb amyotrophy (HP:0008944)1.77276336
167Abnormally folded helix (HP:0008544)1.76506543
168Insulin-resistant diabetes mellitus (HP:0000831)1.76065585
169Poor suck (HP:0002033)1.75483377
170Athetosis (HP:0002305)1.75120078
171Abnormality of the common coagulation pathway (HP:0010990)1.75036727
172Hypoproteinemia (HP:0003075)1.74269828
173Overfolded helix (HP:0000396)1.74188478
174Mediastinal lymphadenopathy (HP:0100721)1.73725560
175Neurofibrillary tangles (HP:0002185)1.72946873
176Enlarged kidneys (HP:0000105)1.72547494
177Hypoglycemic seizures (HP:0002173)1.72348765
178Skin pits (HP:0100276)1.69380822
179Eczematoid dermatitis (HP:0000976)1.67240283
180Abnormal trabecular bone morphology (HP:0100671)1.66206016
181Retrobulbar optic neuritis (HP:0100654)1.65202749
182Optic neuritis (HP:0100653)1.65202749
183Hyperinsulinemic hypoglycemia (HP:0000825)1.64473023
184Abnormality of glutamine family amino acid metabolism (HP:0010902)1.60641985
185Femoral bowing (HP:0002980)1.58856395
186Lymphopenia (HP:0001888)1.58283030
187Xanthomatosis (HP:0000991)1.57966546
188Nasal speech (HP:0001611)1.57474647

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.52709285
2PIK3CG4.39136550
3EEF2K4.11243125
4RIPK43.97566283
5TXK3.65753028
6MAP3K133.51761434
7MST1R3.24234723
8MAP3K93.21202370
9FGFR22.97143506
10FES2.75412576
11MAPKAPK32.58673569
12PRPF4B2.49801847
13ITK2.34838078
14EPHB12.33920228
15ZAP702.22316859
16BTK2.19118524
17IRAK42.14098097
18TAOK32.13979413
19TNK22.10515810
20JAK12.10233988
21GRK62.05508129
22MAP2K32.05266593
23TRPM71.90521684
24INSRR1.89341014
25MAP3K31.86567913
26FGFR41.85549426
27RPS6KB21.85428371
28JAK31.84311164
29SIK31.67245288
30GRK71.61853098
31MAPKAPK51.60112587
32MAP3K21.57336976
33DYRK31.54663348
34MST41.53728011
35EPHB21.52304658
36PRKD11.51319867
37MAP3K121.49758066
38TYRO31.45197408
39TEC1.43159601
40RPS6KA41.42848948
41TLK11.40164052
42MAP3K141.39227524
43EPHA41.39225314
44MARK21.35280585
45MAP3K111.33460719
46MARK31.31813555
47TRIB31.26741027
48NTRK21.24765566
49RPS6KA21.23563770
50LRRK21.21103010
51FGR1.19019585
52MOS1.18705547
53PDK11.16831919
54MAP3K71.16218187
55RET1.14982383
56HIPK21.13266540
57IKBKE1.13151037
58BMPR21.09170323
59FRK1.07924445
60CHUK1.05116493
61FYN1.05056504
62JAK21.03986642
63CSF1R1.01816066
64TAOK11.01640955
65MAP3K10.97798723
66TESK20.95209313
67HCK0.94105622
68IGF1R0.94069356
69TYK20.93762123
70STK100.93398379
71ERBB20.90885707
72KIT0.89711906
73ADRBK10.88983647
74PRKCH0.87411184
75SGK20.86380333
76PIM10.86338169
77MAP2K60.85576391
78MYLK0.84731165
79BLK0.84574526
80FGFR30.83469072
81KSR20.82065315
82LCK0.81720327
83SYK0.80649957
84SIK20.80429599
85MAPK150.80213734
86CDK120.79550293
87RPS6KC10.78950299
88RPS6KL10.78950299
89FER0.78622125
90STK380.77790516
91GRK50.77639195
92YES10.77260162
93RPS6KA60.75459863
94CAMK2D0.74686192
95LYN0.73106988
96MAP2K40.72646061
97MINK10.72382699
98TBK10.71627245
99CASK0.71083333
100PRKAA20.69085973
101TGFBR20.67606310
102RPS6KB10.66977122
103PTK60.66341632
104MAPK120.65985219
105BMX0.65896484
106PRKCQ0.64620069
107CSK0.64146228
108STK110.63751157
109PAK30.63670856
110PRKG10.63264552
111PAK40.61767066
112PTK2B0.61098198
113CDK40.60913468
114MET0.60746530
115SMG10.59495590
116IRAK10.59129914
117SGK4940.58952866
118SGK2230.58952866
119CAMKK10.58785797
120RPS6KA10.58571700
121INSR0.57730865
122GSK3A0.56929854
123NLK0.55762925
124CAMK40.55390013
125MAP2K70.53363624
126PRKCZ0.52467965
127EPHA30.52386970
128MAPK70.50851313
129CAMKK20.49933166
130PDPK10.49635763
131MAPK110.49126894
132ERN10.48963527
133DYRK1B0.48100495
134UHMK10.47629880
135MAP3K100.47382772
136IKBKB0.47088890
137MAPKAPK20.46839558
138SGK30.46307440
139* CDK30.46182691
140ROCK10.45393527
141ICK0.44734069
142KDR0.42918645
143CDK50.42458115
144AKT20.41596109
145TAOK20.41310423
146PRKD20.41022981
147* PRKCE0.40456446
148PKN10.40137072
149CAMK2A0.39019063
150VRK10.38451559
151MATK0.38438388
152MAP3K50.35957805
153CDK190.35941434
154RIPK10.34724496
155MELK0.33078053
156BRD40.31366711
157CDC42BPA0.29985355

Predicted pathways (KEGG)

RankGene SetZ-score
1* Graft-versus-host disease_Homo sapiens_hsa053326.60709227
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.54865559
3* Antigen processing and presentation_Homo sapiens_hsa046123.38480408
4Olfactory transduction_Homo sapiens_hsa047403.05244318
5* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.73019174
6Hematopoietic cell lineage_Homo sapiens_hsa046402.64022757
7Allograft rejection_Homo sapiens_hsa053302.62827566
8Autoimmune thyroid disease_Homo sapiens_hsa053202.43064743
9Nitrogen metabolism_Homo sapiens_hsa009102.42761268
10T cell receptor signaling pathway_Homo sapiens_hsa046602.41532495
11B cell receptor signaling pathway_Homo sapiens_hsa046622.32962126
12Primary immunodeficiency_Homo sapiens_hsa053402.31562389
13Leishmaniasis_Homo sapiens_hsa051402.30040774
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.09970237
15Type I diabetes mellitus_Homo sapiens_hsa049401.92562862
16Viral myocarditis_Homo sapiens_hsa054161.89287300
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.84553293
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.80452607
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71740608
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.64937462
21Collecting duct acid secretion_Homo sapiens_hsa049661.58360861
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.54430083
23Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.53301862
24Acute myeloid leukemia_Homo sapiens_hsa052211.44612847
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43496739
26Measles_Homo sapiens_hsa051621.38189290
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35917719
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32569669
29Vibrio cholerae infection_Homo sapiens_hsa051101.31363248
30Herpes simplex infection_Homo sapiens_hsa051681.28988553
31Toxoplasmosis_Homo sapiens_hsa051451.27256135
32Influenza A_Homo sapiens_hsa051641.24875106
33VEGF signaling pathway_Homo sapiens_hsa043701.22740767
34Hepatitis B_Homo sapiens_hsa051611.20108508
35TNF signaling pathway_Homo sapiens_hsa046681.17979756
36Cocaine addiction_Homo sapiens_hsa050301.14659304
37ErbB signaling pathway_Homo sapiens_hsa040121.14248862
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.13323831
39Renin secretion_Homo sapiens_hsa049241.07785618
40Pancreatic cancer_Homo sapiens_hsa052121.07702440
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00998376
42African trypanosomiasis_Homo sapiens_hsa051431.00589744
43Fatty acid elongation_Homo sapiens_hsa000620.99612935
44Oxytocin signaling pathway_Homo sapiens_hsa049210.97812562
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97488576
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95844784
47Shigellosis_Homo sapiens_hsa051310.92451633
48Hepatitis C_Homo sapiens_hsa051600.92348115
49Legionellosis_Homo sapiens_hsa051340.88982793
50Apoptosis_Homo sapiens_hsa042100.88005784
51Chronic myeloid leukemia_Homo sapiens_hsa052200.87110650
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.86084031
53Phagosome_Homo sapiens_hsa041450.84879557
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84275206
55Endocytosis_Homo sapiens_hsa041440.82307172
56Renal cell carcinoma_Homo sapiens_hsa052110.80785825
57Circadian entrainment_Homo sapiens_hsa047130.80596995
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.79725793
59Amphetamine addiction_Homo sapiens_hsa050310.79293382
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79066500
61Asthma_Homo sapiens_hsa053100.78980517
62Epstein-Barr virus infection_Homo sapiens_hsa051690.77769397
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76595959
64Pertussis_Homo sapiens_hsa051330.75018833
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73686478
66Colorectal cancer_Homo sapiens_hsa052100.73282980
67Complement and coagulation cascades_Homo sapiens_hsa046100.73004452
68Folate biosynthesis_Homo sapiens_hsa007900.72498061
69Choline metabolism in cancer_Homo sapiens_hsa052310.72262314
70Rheumatoid arthritis_Homo sapiens_hsa053230.71890481
71Prolactin signaling pathway_Homo sapiens_hsa049170.71822202
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.71463764
73Salmonella infection_Homo sapiens_hsa051320.70350262
74Tryptophan metabolism_Homo sapiens_hsa003800.69684661
75HTLV-I infection_Homo sapiens_hsa051660.68730558
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68064268
77Amoebiasis_Homo sapiens_hsa051460.67698904
78Type II diabetes mellitus_Homo sapiens_hsa049300.66431176
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.65983758
80Viral carcinogenesis_Homo sapiens_hsa052030.65877215
81Gastric acid secretion_Homo sapiens_hsa049710.65711356
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.63963012
83Bile secretion_Homo sapiens_hsa049760.63763578
84Prion diseases_Homo sapiens_hsa050200.63599815
85Chemokine signaling pathway_Homo sapiens_hsa040620.63533116
86Ras signaling pathway_Homo sapiens_hsa040140.63259945
87Melanogenesis_Homo sapiens_hsa049160.61808436
88Platelet activation_Homo sapiens_hsa046110.61266161
89Endometrial cancer_Homo sapiens_hsa052130.58753743
90PPAR signaling pathway_Homo sapiens_hsa033200.58687000
91Caffeine metabolism_Homo sapiens_hsa002320.58430666
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58322127
93Arginine biosynthesis_Homo sapiens_hsa002200.56984698
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56241359
95Staphylococcus aureus infection_Homo sapiens_hsa051500.56171999
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56096140
97Sphingolipid metabolism_Homo sapiens_hsa006000.55847866
98Ribosome_Homo sapiens_hsa030100.55658343
99Osteoclast differentiation_Homo sapiens_hsa043800.54870788
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53830489
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53802021
102Salivary secretion_Homo sapiens_hsa049700.53700266
103Cholinergic synapse_Homo sapiens_hsa047250.53324755
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51715132
105mTOR signaling pathway_Homo sapiens_hsa041500.51712747
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51384423
107GABAergic synapse_Homo sapiens_hsa047270.51298915
108Tuberculosis_Homo sapiens_hsa051520.51162452
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.50817178
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50143630
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49826973
112Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49499933
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48383794
114Proteoglycans in cancer_Homo sapiens_hsa052050.48198537
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47795325
116Glutamatergic synapse_Homo sapiens_hsa047240.47481269
117Notch signaling pathway_Homo sapiens_hsa043300.47261718
118MAPK signaling pathway_Homo sapiens_hsa040100.47091115
119Inositol phosphate metabolism_Homo sapiens_hsa005620.46118950
120Dilated cardiomyopathy_Homo sapiens_hsa054140.45654091
121Regulation of autophagy_Homo sapiens_hsa041400.44889513
122Ovarian steroidogenesis_Homo sapiens_hsa049130.44872746
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44405001
124Serotonergic synapse_Homo sapiens_hsa047260.44264511
125Histidine metabolism_Homo sapiens_hsa003400.43843493
126Rap1 signaling pathway_Homo sapiens_hsa040150.42943615
127Starch and sucrose metabolism_Homo sapiens_hsa005000.42701713
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42540646
129Thyroid hormone synthesis_Homo sapiens_hsa049180.42444606
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41876756
131Mineral absorption_Homo sapiens_hsa049780.41660886
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41266526
133Estrogen signaling pathway_Homo sapiens_hsa049150.40754814
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40307830
135Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39484738
136Lysosome_Homo sapiens_hsa041420.39444820
137Hippo signaling pathway_Homo sapiens_hsa043900.39429857
138FoxO signaling pathway_Homo sapiens_hsa040680.39292557
139Dorso-ventral axis formation_Homo sapiens_hsa043200.39290732
140Synaptic vesicle cycle_Homo sapiens_hsa047210.39221277
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38228893
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.38172253
143Axon guidance_Homo sapiens_hsa043600.37340668
144Insulin resistance_Homo sapiens_hsa049310.37071968
145Insulin secretion_Homo sapiens_hsa049110.36735699
146GnRH signaling pathway_Homo sapiens_hsa049120.36252614
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.35650739
148Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35382541
149Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34820325
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.34528194
151MicroRNAs in cancer_Homo sapiens_hsa052060.34292591
152Malaria_Homo sapiens_hsa051440.33252238
153ABC transporters_Homo sapiens_hsa020100.33201675
154Adherens junction_Homo sapiens_hsa045200.32331118
155Glioma_Homo sapiens_hsa052140.32114712
156Dopaminergic synapse_Homo sapiens_hsa047280.32073758
157Non-small cell lung cancer_Homo sapiens_hsa052230.31744660
158Taste transduction_Homo sapiens_hsa047420.31561586
159Chemical carcinogenesis_Homo sapiens_hsa052040.31468137
160Ether lipid metabolism_Homo sapiens_hsa005650.31203596
161Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30965611
162Prostate cancer_Homo sapiens_hsa052150.30895469
163Other glycan degradation_Homo sapiens_hsa005110.30197407
164HIF-1 signaling pathway_Homo sapiens_hsa040660.29984905

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