ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.54161472
2	L-fucose catabolic process (GO:0042355)	4.61404336
3	fucose catabolic process (GO:0019317)	4.61404336
4	L-fucose metabolic process (GO:0042354)	4.61404336
5	DNA deamination (GO:0045006)	4.43437054
6	indolalkylamine metabolic process (GO:0006586)	4.19567875
7	response to pheromone (GO:0019236)	4.10693256
8	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.07089900
9	indole-containing compound catabolic process (GO:0042436)	4.01499375
10	indolalkylamine catabolic process (GO:0046218)	4.01499375
11	tryptophan catabolic process (GO:0006569)	4.01499375
12	detection of light stimulus involved in sensory perception (GO:0050962)	3.94002000
13	detection of light stimulus involved in visual perception (GO:0050908)	3.94002000
14	kynurenine metabolic process (GO:0070189)	3.72004287
15	cellular ketone body metabolic process (GO:0046950)	3.60524554
16	tryptophan metabolic process (GO:0006568)	3.39856486
17	ketone body metabolic process (GO:1902224)	3.22646963
18	water-soluble vitamin biosynthetic process (GO:0042364)	3.21708409
19	reflex (GO:0060004)	3.10458083
20	indole-containing compound metabolic process (GO:0042430)	3.09930080
21	protein polyglutamylation (GO:0018095)	3.04493362
22	piRNA metabolic process (GO:0034587)	3.01779022
23	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.99359032
24	gamma-aminobutyric acid transport (GO:0015812)	2.98694077
25	signal peptide processing (GO:0006465)	2.98382661
26	cytidine metabolic process (GO:0046087)	2.96494876
27	cytidine catabolic process (GO:0006216)	2.96494876
28	cytidine deamination (GO:0009972)	2.96494876
29	axoneme assembly (GO:0035082)	2.95223996
30	neural tube formation (GO:0001841)	2.94825482
31	amine catabolic process (GO:0009310)	2.93952082
32	cellular biogenic amine catabolic process (GO:0042402)	2.93952082
33	cilium or flagellum-dependent cell motility (GO:0001539)	2.90982027
34	photoreceptor cell maintenance (GO:0045494)	2.90820952
35	retinal cone cell development (GO:0046549)	2.87158565
36	behavioral response to ethanol (GO:0048149)	2.86191406
37	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.84516976
38	respiratory chain complex IV assembly (GO:0008535)	2.84258900
39	nonmotile primary cilium assembly (GO:0035058)	2.80901370
40	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.80707670
41	transmission of nerve impulse (GO:0019226)	2.78869152
42	platelet dense granule organization (GO:0060155)	2.78423321
43	protein complex biogenesis (GO:0070271)	2.78096256
44	cilium morphogenesis (GO:0060271)	2.76914617
45	sulfation (GO:0051923)	2.74233843
46	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.73808929
47	multicellular organism reproduction (GO:0032504)	2.73705742
48	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.73606158
49	cAMP catabolic process (GO:0006198)	2.73522409
50	primary amino compound metabolic process (GO:1901160)	2.72268695
51	auditory receptor cell stereocilium organization (GO:0060088)	2.72168559
52	neuronal action potential (GO:0019228)	2.71890649
53	negative regulation of telomere maintenance (GO:0032205)	2.71348563
54	epithelial cilium movement (GO:0003351)	2.71214438
55	tachykinin receptor signaling pathway (GO:0007217)	2.69762299
56	serotonin metabolic process (GO:0042428)	2.68233132
57	rhodopsin mediated signaling pathway (GO:0016056)	2.67921925
58	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.67568998
59	NADH dehydrogenase complex assembly (GO:0010257)	2.67568998
60	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.67568998
61	positive regulation of defense response to virus by host (GO:0002230)	2.67335670
62	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.63626192
63	cytochrome complex assembly (GO:0017004)	2.63284635
64	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.62583224
65	regulation of action potential (GO:0098900)	2.61467788
66	protein K11-linked deubiquitination (GO:0035871)	2.60178778
67	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.59795042
68	DNA methylation involved in gamete generation (GO:0043046)	2.59649514
69	regulation of neurotransmitter uptake (GO:0051580)	2.58131634
70	cilium organization (GO:0044782)	2.58051653
71	cyclic nucleotide catabolic process (GO:0009214)	2.57322359
72	oxidative demethylation (GO:0070989)	2.56289557
73	photoreceptor cell development (GO:0042461)	2.55754562
74	cornea development in camera-type eye (GO:0061303)	2.55669752
75	nucleoside transmembrane transport (GO:1901642)	2.55429366
76	reciprocal DNA recombination (GO:0035825)	2.55043051
77	reciprocal meiotic recombination (GO:0007131)	2.55043051
78	mitochondrial respiratory chain complex assembly (GO:0033108)	2.54837860
79	kidney morphogenesis (GO:0060993)	2.54042205
80	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.52728608
81	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.52728608
82	synaptic transmission, cholinergic (GO:0007271)	2.52508504
83	adaptation of signaling pathway (GO:0023058)	2.52202211
84	negative regulation of mast cell activation (GO:0033004)	2.51667189
85	cilium assembly (GO:0042384)	2.50842391
86	positive regulation of fatty acid transport (GO:2000193)	2.50634192
87	recombinational repair (GO:0000725)	2.50023605
88	double-strand break repair via homologous recombination (GO:0000724)	2.49637267
89	replication fork processing (GO:0031297)	2.49408438
90	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.49030512
91	regulation of translation, ncRNA-mediated (GO:0045974)	2.49030512
92	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.49030512
93	preassembly of GPI anchor in ER membrane (GO:0016254)	2.47438984
94	NAD biosynthetic process (GO:0009435)	2.47348397
95	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.46801022
96	interferon-gamma production (GO:0032609)	2.46573953
97	regulation of cilium movement (GO:0003352)	2.46353647
98	inner ear receptor stereocilium organization (GO:0060122)	2.45548789
99	regulation of hippo signaling (GO:0035330)	2.45183699
100	endoderm formation (GO:0001706)	2.44995992

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.58999993
2	VDR_22108803_ChIP-Seq_LS180_Human	3.24351515
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.16835517
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.07224409
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.88360556
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.63429051
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.55264318
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.38547243
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.37732570
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.30215983
11	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.19484879
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.12536618
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.10831043
14	P300_19829295_ChIP-Seq_ESCs_Human	2.07775229
15	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.07661363
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.04348955
17	EWS_26573619_Chip-Seq_HEK293_Human	2.02853048
18	FUS_26573619_Chip-Seq_HEK293_Human	1.98208253
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.87803347
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.78887857
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.76963742
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.75146116
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.74993041
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.68517843
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.67131712
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.66563061
27	STAT3_23295773_ChIP-Seq_U87_Human	1.64662585
28	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.63728411
29	SMAD4_21799915_ChIP-Seq_A2780_Human	1.59522411
30	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.59108754
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.58115373
32	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.57935813
33	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.56551650
34	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.56349608
35	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.52315206
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.52315206
37	CBP_20019798_ChIP-Seq_JUKART_Human	1.52091161
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.52091161
39	TCF4_23295773_ChIP-Seq_U87_Human	1.49265795
40	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.49121410
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.48070392
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44404304
43	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.42978778
44	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.42250506
45	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.41151745
46	* AR_25329375_ChIP-Seq_VCAP_Human	1.40805918
47	TCF4_22108803_ChIP-Seq_LS180_Human	1.39885799
48	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.38089360
49	REST_21632747_ChIP-Seq_MESCs_Mouse	1.37855867
50	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.37440512
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35626933
52	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35626933
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.35229241
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.32447602
55	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.32237246
56	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.31319379
57	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31128263
58	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.30723908
59	IRF1_19129219_ChIP-ChIP_H3396_Human	1.28187494
60	AR_21572438_ChIP-Seq_LNCaP_Human	1.28172008
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26645129
62	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26645129
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.26229075
64	RNF2_27304074_Chip-Seq_NSC_Mouse	1.25560167
65	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.24688133
66	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24171540
67	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24091674
68	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21071046
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.20485235
70	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.19881868
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18579639
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.18206908
73	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.15889038
74	CDX2_22108803_ChIP-Seq_LS180_Human	1.15744336
75	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14828366
76	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12089015
77	NCOR_22424771_ChIP-Seq_293T_Human	1.11658263
78	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11235416
79	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.10950972
80	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.10707106
81	AR_20517297_ChIP-Seq_VCAP_Human	1.09229109
82	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.09039903
83	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08931503
84	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.07378941
85	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05375474
86	MYC_18940864_ChIP-ChIP_HL60_Human	1.04877246
87	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04122572
88	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.02529104
89	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02175827
90	DROSHA_22980978_ChIP-Seq_HELA_Human	0.98585237
91	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.98460269
92	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.97911778
93	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.96869709
94	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.94829607
95	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94599699
96	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.94388592
97	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.94228821
98	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.93532374
99	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.93502956
100	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.93442190

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.25304695
2	MP0008877_abnormal_DNA_methylation	2.83418107
3	MP0005551_abnormal_eye_electrophysiolog	2.66237060
4	MP0003646_muscle_fatigue	2.64839848
5	MP0000569_abnormal_digit_pigmentation	2.45848042
6	MP0002638_abnormal_pupillary_reflex	2.36637338
7	MP0006072_abnormal_retinal_apoptosis	2.34715374
8	MP0001968_abnormal_touch/_nociception	2.33349466
9	MP0004043_abnormal_pH_regulation	2.23208186
10	MP0002102_abnormal_ear_morphology	2.14440442
11	MP0009046_muscle_twitch	2.12390456
12	MP0001501_abnormal_sleep_pattern	2.08123237
13	MP0002837_dystrophic_cardiac_calcinosis	2.05129184
14	MP0002736_abnormal_nociception_after	2.00156322
15	MP0009745_abnormal_behavioral_response	1.99750546
16	MP0003136_yellow_coat_color	1.95437789
17	MP0005253_abnormal_eye_physiology	1.91475890
18	MP0008872_abnormal_physiological_respon	1.91086660
19	MP0002876_abnormal_thyroid_physiology	1.89260522
20	MP0005646_abnormal_pituitary_gland	1.87907714
21	MP0003787_abnormal_imprinting	1.86238687
22	MP0001485_abnormal_pinna_reflex	1.79923186
23	MP0004142_abnormal_muscle_tone	1.78843564
24	MP0000372_irregular_coat_pigmentation	1.77188580
25	MP0005645_abnormal_hypothalamus_physiol	1.75291930
26	MP0005174_abnormal_tail_pigmentation	1.71994072
27	MP0001986_abnormal_taste_sensitivity	1.71888359
28	MP0000427_abnormal_hair_cycle	1.71555221
29	MP0006276_abnormal_autonomic_nervous	1.70943855
30	MP0003880_abnormal_central_pattern	1.64895296
31	MP0004147_increased_porphyrin_level	1.63619182
32	MP0002272_abnormal_nervous_system	1.63164317
33	MP0004133_heterotaxia	1.62352849
34	MP0004885_abnormal_endolymph	1.55354092
35	MP0001486_abnormal_startle_reflex	1.54458644
36	MP0006292_abnormal_olfactory_placode	1.48465195
37	MP0010386_abnormal_urinary_bladder	1.40240068
38	MP0000631_abnormal_neuroendocrine_gland	1.39389209
39	MP0002163_abnormal_gland_morphology	1.37776809
40	MP0008875_abnormal_xenobiotic_pharmacok	1.36863289
41	MP0002572_abnormal_emotion/affect_behav	1.33021684
42	MP0002653_abnormal_ependyma_morphology	1.32055514
43	MP0002064_seizures	1.27541023
44	MP0002557_abnormal_social/conspecific_i	1.26176632
45	MP0001529_abnormal_vocalization	1.25124872
46	MP0004742_abnormal_vestibular_system	1.24005568
47	MP0001970_abnormal_pain_threshold	1.23897465
48	MP0002733_abnormal_thermal_nociception	1.23567697
49	MP0004924_abnormal_behavior	1.23503408
50	MP0005386_behavior/neurological_phenoty	1.23503408
51	MP0002735_abnormal_chemical_nociception	1.23023724
52	MP0001984_abnormal_olfaction	1.21992747
53	MP0002938_white_spotting	1.21109971
54	MP0002138_abnormal_hepatobiliary_system	1.20871532
55	MP0005084_abnormal_gallbladder_morpholo	1.20727540
56	MP0004145_abnormal_muscle_electrophysio	1.19484689
57	MP0003011_delayed_dark_adaptation	1.16829526
58	MP0002928_abnormal_bile_duct	1.15397234
59	MP0003890_abnormal_embryonic-extraembry	1.12212332
60	MP0005379_endocrine/exocrine_gland_phen	1.12202467
61	MP0002160_abnormal_reproductive_system	1.11318882
62	MP0002067_abnormal_sensory_capabilities	1.11168669
63	MP0005195_abnormal_posterior_eye	1.10925482
64	MP0005389_reproductive_system_phenotype	1.08967362
65	MP0000383_abnormal_hair_follicle	1.07614771
66	MP0003635_abnormal_synaptic_transmissio	1.06650561
67	MP0000230_abnormal_systemic_arterial	1.06323024
68	MP0008775_abnormal_heart_ventricle	1.03263537
69	MP0002095_abnormal_skin_pigmentation	1.03161347
70	MP0002063_abnormal_learning/memory/cond	1.01122313
71	MP0005410_abnormal_fertilization	1.00918240
72	MP0003252_abnormal_bile_duct	1.00883463
73	MP0005671_abnormal_response_to	1.00482385
74	MP0005085_abnormal_gallbladder_physiolo	0.96170528
75	MP0004215_abnormal_myocardial_fiber	0.94983896
76	MP0005167_abnormal_blood-brain_barrier	0.94724413
77	MP0002234_abnormal_pharynx_morphology	0.94628370
78	MP0003878_abnormal_ear_physiology	0.94476361
79	MP0005377_hearing/vestibular/ear_phenot	0.94476361
80	MP0002229_neurodegeneration	0.93418967
81	MP0002734_abnormal_mechanical_nocicepti	0.91993291
82	MP0001905_abnormal_dopamine_level	0.91457903
83	MP0002752_abnormal_somatic_nervous	0.89857435
84	MP0008995_early_reproductive_senescence	0.89518031
85	MP0002693_abnormal_pancreas_physiology	0.88283507
86	MP0001963_abnormal_hearing_physiology	0.86052842
87	MP0003137_abnormal_impulse_conducting	0.83005965
88	MP0002751_abnormal_autonomic_nervous	0.82709255
89	MP0003698_abnormal_male_reproductive	0.82266580
90	MP0005075_abnormal_melanosome_morpholog	0.82129626
91	MP0000026_abnormal_inner_ear	0.81946789
92	MP0003718_maternal_effect	0.81792462
93	MP0000778_abnormal_nervous_system	0.80358598
94	MP0000538_abnormal_urinary_bladder	0.79827331
95	MP0003283_abnormal_digestive_organ	0.79744912
96	MP0001324_abnormal_eye_pigmentation	0.77555570
97	MP0001919_abnormal_reproductive_system	0.77516612
98	MP0002184_abnormal_innervation	0.76462380
99	MP0002210_abnormal_sex_determination	0.75308173
100	MP0003121_genomic_imprinting	0.74484742

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.57454169
2	Congenital stationary night blindness (HP:0007642)	4.40811015
3	Molar tooth sign on MRI (HP:0002419)	4.20949188
4	Abnormality of midbrain morphology (HP:0002418)	4.20949188
5	Pancreatic fibrosis (HP:0100732)	4.05488001
6	True hermaphroditism (HP:0010459)	4.00802076
7	Nephronophthisis (HP:0000090)	3.46583002
8	Abnormality of the renal cortex (HP:0011035)	3.32814766
9	Attenuation of retinal blood vessels (HP:0007843)	3.22894719
10	Abnormality of the renal medulla (HP:0100957)	3.09449433
11	Medial flaring of the eyebrow (HP:0010747)	3.07552801
12	Hyperventilation (HP:0002883)	3.01333829
13	Abolished electroretinogram (ERG) (HP:0000550)	2.93884696
14	Type II lissencephaly (HP:0007260)	2.89541588
15	Chronic hepatic failure (HP:0100626)	2.85778969
16	Gaze-evoked nystagmus (HP:0000640)	2.85210221
17	Cystic liver disease (HP:0006706)	2.77871722
18	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.72620204
19	Abnormality of alanine metabolism (HP:0010916)	2.72620204
20	Hyperalaninemia (HP:0003348)	2.72620204
21	Progressive cerebellar ataxia (HP:0002073)	2.72614426
22	Abnormal rod and cone electroretinograms (HP:0008323)	2.67989190
23	Renal cortical cysts (HP:0000803)	2.67349371
24	Genetic anticipation (HP:0003743)	2.56287937
25	Inability to walk (HP:0002540)	2.48123902
26	Sclerocornea (HP:0000647)	2.43017934
27	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.42001226
28	Tubular atrophy (HP:0000092)	2.41564987
29	Large for gestational age (HP:0001520)	2.41467903
30	Methylmalonic acidemia (HP:0002912)	2.41268772
31	Pendular nystagmus (HP:0012043)	2.39425196
32	Gait imbalance (HP:0002141)	2.38474005
33	Bony spicule pigmentary retinopathy (HP:0007737)	2.34379149
34	Congenital primary aphakia (HP:0007707)	2.33507502
35	Decreased central vision (HP:0007663)	2.33209557
36	Increased corneal curvature (HP:0100692)	2.30790902
37	Keratoconus (HP:0000563)	2.30790902
38	Progressive inability to walk (HP:0002505)	2.30673292
39	Congenital sensorineural hearing impairment (HP:0008527)	2.29509932
40	Congenital, generalized hypertrichosis (HP:0004540)	2.28604713
41	Polydipsia (HP:0001959)	2.28454726
42	Abnormal drinking behavior (HP:0030082)	2.28454726
43	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.28015632
44	Clumsiness (HP:0002312)	2.25443915
45	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.21954160
46	Absent/shortened dynein arms (HP:0200106)	2.18615514
47	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.18615514
48	Broad-based gait (HP:0002136)	2.17782624
49	Furrowed tongue (HP:0000221)	2.16821986
50	Bile duct proliferation (HP:0001408)	2.16767762
51	Abnormal biliary tract physiology (HP:0012439)	2.16767762
52	Ketoacidosis (HP:0001993)	2.15695281
53	Decreased circulating renin level (HP:0003351)	2.14502757
54	Methylmalonic aciduria (HP:0012120)	2.14227108
55	Chorioretinal atrophy (HP:0000533)	2.13409026
56	Nephrogenic diabetes insipidus (HP:0009806)	2.12175696
57	Anencephaly (HP:0002323)	2.11151894
58	Congenital hepatic fibrosis (HP:0002612)	2.09113952
59	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.04348623
60	Abnormality of macular pigmentation (HP:0008002)	2.04116031
61	Abnormality of the pons (HP:0007361)	2.03515330
62	Febrile seizures (HP:0002373)	2.01385956
63	Male pseudohermaphroditism (HP:0000037)	2.01270028
64	Genital tract atresia (HP:0001827)	2.00691160
65	Hypothermia (HP:0002045)	1.99784233
66	Ketosis (HP:0001946)	1.98790071
67	Hypoplasia of the pons (HP:0012110)	1.98182772
68	Protruding tongue (HP:0010808)	1.98056391
69	Agitation (HP:0000713)	1.97930249
70	Lissencephaly (HP:0001339)	1.96276017
71	Polyuria (HP:0000103)	1.94633532
72	3-Methylglutaconic aciduria (HP:0003535)	1.94360804
73	Fair hair (HP:0002286)	1.94048420
74	Cerebellar dysplasia (HP:0007033)	1.93998607
75	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.93600469
76	Vaginal atresia (HP:0000148)	1.91911526
77	Increased CSF lactate (HP:0002490)	1.91501059
78	Hypoplasia of the fovea (HP:0007750)	1.91230392
79	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.91230392
80	Optic nerve hypoplasia (HP:0000609)	1.86863038
81	Postaxial foot polydactyly (HP:0001830)	1.84618729
82	Intestinal atresia (HP:0011100)	1.84422312
83	Retinitis pigmentosa (HP:0000510)	1.82396934
84	Hemiparesis (HP:0001269)	1.82243065
85	Dyskinesia (HP:0100660)	1.80471866
86	Hyperglycinemia (HP:0002154)	1.79030250
87	Abnormal ciliary motility (HP:0012262)	1.77463470
88	Mitochondrial inheritance (HP:0001427)	1.75497520
89	Patellar aplasia (HP:0006443)	1.74850364
90	Thyroiditis (HP:0100646)	1.74204921
91	Stomach cancer (HP:0012126)	1.72929986
92	Hypoproteinemia (HP:0003075)	1.70881490
93	Absent speech (HP:0001344)	1.70662935
94	Abnormal respiratory epithelium morphology (HP:0012253)	1.70459960
95	Abnormal respiratory motile cilium morphology (HP:0005938)	1.70459960
96	Tachypnea (HP:0002789)	1.70350581
97	Constricted visual fields (HP:0001133)	1.70108250
98	Retinal dysplasia (HP:0007973)	1.68215608
99	Focal seizures (HP:0007359)	1.67281360
100	Abnormality of the fovea (HP:0000493)	1.66125876

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.09698612
2	BMPR1B	3.48314744
3	ADRBK2	3.32853229
4	MAP4K2	2.73033338
5	ACVR1B	2.58411458
6	WNK3	2.44411853
7	GRK1	2.38406469
8	ZAK	2.25599599
9	NUAK1	2.22412589
10	TAOK3	2.19879040
11	WNK4	2.15673071
12	INSRR	2.07728688
13	TXK	1.94695938
14	PINK1	1.89264820
15	CASK	1.80340908
16	MAPK13	1.75529669
17	OXSR1	1.64536208
18	STK39	1.56151900
19	TLK1	1.55150449
20	MKNK2	1.41886165
21	MAP3K4	1.38116423
22	MAP2K6	1.34903026
23	TNIK	1.32602336
24	ADRBK1	1.31258291
25	DAPK2	1.28304685
26	NTRK3	1.21712027
27	PAK3	1.13075442
28	TGFBR1	1.11755815
29	TRIM28	1.07810129
30	PRKCE	0.96100162
31	PRKCG	0.95118330
32	MAPKAPK3	0.91159822
33	TEC	0.90612386
34	PTK2B	0.84280576
35	PLK2	0.81337318
36	BCKDK	0.80735023
37	MUSK	0.79450296
38	PIK3CA	0.75106993
39	TNK2	0.74971109
40	STK38L	0.74903668
41	DYRK2	0.73715031
42	PHKG1	0.72839047
43	PHKG2	0.72839047
44	PNCK	0.71293647
45	VRK1	0.71186192
46	MARK1	0.70964353
47	PIK3CG	0.70964056
48	CSNK1G1	0.68128437
49	AKT3	0.67950654
50	CAMKK2	0.67832221
51	MAP2K7	0.67664869
52	CSNK1G2	0.67171460
53	ITK	0.66676239
54	TIE1	0.66473786
55	STK3	0.66469608
56	PKN1	0.62737092
57	TAF1	0.62079380
58	MST4	0.60658611
59	PRKCQ	0.60195382
60	KIT	0.60000301
61	CAMK2A	0.59766279
62	OBSCN	0.59511262
63	FGFR2	0.59496492
64	NLK	0.57475295
65	PLK4	0.57378301
66	CSNK1G3	0.56713102
67	IKBKB	0.54771572
68	CSNK1A1L	0.54128622
69	NTRK2	0.53379127
70	EIF2AK3	0.52813571
71	MKNK1	0.51627776
72	MAPKAPK5	0.51281910
73	STK16	0.50675894
74	PDK2	0.49117480
75	PRKACA	0.49051457
76	GRK7	0.48944335
77	SYK	0.48156136
78	STK11	0.46543642
79	ERBB3	0.46284652
80	BCR	0.44296444
81	IRAK1	0.43921465
82	GRK5	0.43524912
83	MAPK15	0.43391157
84	TRPM7	0.42839587
85	BRSK2	0.40609426
86	SIK2	0.39395140
87	PRKCA	0.38400912
88	CSNK1A1	0.38340539
89	CSNK1D	0.36893979
90	PLK3	0.36844903
91	RPS6KA5	0.36593352
92	PRKAA2	0.35538668
93	EPHA4	0.34939894
94	NEK2	0.34079471
95	CAMK1	0.33324767
96	FLT3	0.33318633
97	PRKG1	0.32539511
98	SGK2	0.31977234
99	FER	0.31131652
100	LCK	0.29940338

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.01922987
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.83951692
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.74011251
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.53067707
5	Butanoate metabolism_Homo sapiens_hsa00650	2.43804265
6	Nicotine addiction_Homo sapiens_hsa05033	2.26025678
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.24678865
8	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.12119220
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.08778250
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.07692739
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.00010621
12	Ether lipid metabolism_Homo sapiens_hsa00565	1.94372060
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.93123941
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.90727903
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.87714189
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.80138620
17	Homologous recombination_Homo sapiens_hsa03440	1.76322661
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.73791696
19	Oxidative phosphorylation_Homo sapiens_hsa00190	1.64528620
20	Morphine addiction_Homo sapiens_hsa05032	1.52217670
21	Caffeine metabolism_Homo sapiens_hsa00232	1.50314135
22	Taste transduction_Homo sapiens_hsa04742	1.50273127
23	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.48921192
24	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.47600342
25	Olfactory transduction_Homo sapiens_hsa04740	1.45554936
26	RNA polymerase_Homo sapiens_hsa03020	1.45472035
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.45151830
28	Regulation of autophagy_Homo sapiens_hsa04140	1.44649863
29	Propanoate metabolism_Homo sapiens_hsa00640	1.44220376
30	ABC transporters_Homo sapiens_hsa02010	1.41797087
31	Basal transcription factors_Homo sapiens_hsa03022	1.39852001
32	Protein export_Homo sapiens_hsa03060	1.39071252
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.34360636
34	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.23259493
35	GABAergic synapse_Homo sapiens_hsa04727	1.19101108
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.18905922
37	Parkinsons disease_Homo sapiens_hsa05012	1.17490877
38	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.17176914
39	Chemical carcinogenesis_Homo sapiens_hsa05204	1.16038599
40	Serotonergic synapse_Homo sapiens_hsa04726	1.15438362
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.15290332
42	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.13837119
43	Insulin secretion_Homo sapiens_hsa04911	1.11980321
44	Peroxisome_Homo sapiens_hsa04146	1.10760976
45	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.10727101
46	RNA degradation_Homo sapiens_hsa03018	1.10273973
47	Sulfur metabolism_Homo sapiens_hsa00920	1.08263925
48	Retinol metabolism_Homo sapiens_hsa00830	1.07487426
49	Circadian entrainment_Homo sapiens_hsa04713	1.06591859
50	Glutamatergic synapse_Homo sapiens_hsa04724	1.04162153
51	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.03963740
52	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.98197911
53	One carbon pool by folate_Homo sapiens_hsa00670	0.90733783
54	Primary immunodeficiency_Homo sapiens_hsa05340	0.85599012
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.84398160
56	Salivary secretion_Homo sapiens_hsa04970	0.83810412
57	Calcium signaling pathway_Homo sapiens_hsa04020	0.82151209
58	Glycerolipid metabolism_Homo sapiens_hsa00561	0.81715614
59	Huntingtons disease_Homo sapiens_hsa05016	0.81230347
60	Cardiac muscle contraction_Homo sapiens_hsa04260	0.81121967
61	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.80814581
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.79872922
63	Type I diabetes mellitus_Homo sapiens_hsa04940	0.78088881
64	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.77564498
65	Graft-versus-host disease_Homo sapiens_hsa05332	0.77282321
66	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.77162966
67	Collecting duct acid secretion_Homo sapiens_hsa04966	0.75441323
68	Alzheimers disease_Homo sapiens_hsa05010	0.75150700
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.68472487
70	Purine metabolism_Homo sapiens_hsa00230	0.64525387
71	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.61634163
72	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.60928275
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.60435518
74	Histidine metabolism_Homo sapiens_hsa00340	0.60095815
75	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.57920003
76	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.57847227
77	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.57474014
78	Asthma_Homo sapiens_hsa05310	0.57391354
79	Dopaminergic synapse_Homo sapiens_hsa04728	0.55566673
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.54555092
81	Long-term depression_Homo sapiens_hsa04730	0.54470997
82	Non-homologous end-joining_Homo sapiens_hsa03450	0.53782746
83	Metabolic pathways_Homo sapiens_hsa01100	0.53438023
84	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.53359312
85	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.53279457
86	Allograft rejection_Homo sapiens_hsa05330	0.51116949
87	Cocaine addiction_Homo sapiens_hsa05030	0.43333909
88	Cholinergic synapse_Homo sapiens_hsa04725	0.39816168
89	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.39732940
90	Circadian rhythm_Homo sapiens_hsa04710	0.39676614
91	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.39124991
92	cAMP signaling pathway_Homo sapiens_hsa04024	0.38861621
93	Mineral absorption_Homo sapiens_hsa04978	0.37583886
94	Renin secretion_Homo sapiens_hsa04924	0.37521276
95	Amphetamine addiction_Homo sapiens_hsa05031	0.36693332
96	Fatty acid degradation_Homo sapiens_hsa00071	0.36166049
97	Sphingolipid metabolism_Homo sapiens_hsa00600	0.33535339
98	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.32855008
99	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.31382929
100	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.30599851

KIR3DX1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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