KIRREL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bone trabecula formation (GO:0060346)5.57530221
2hemidesmosome assembly (GO:0031581)5.15215686
3protein heterotrimerization (GO:0070208)4.77490853
4collagen fibril organization (GO:0030199)4.43228924
5cell-substrate junction assembly (GO:0007044)4.15410861
6chondrocyte proliferation (GO:0035988)4.10060582
7notochord development (GO:0030903)4.09858240
8heterochromatin organization (GO:0070828)4.08490715
9axon extension involved in axon guidance (GO:0048846)4.04190858
10neuron projection extension involved in neuron projection guidance (GO:1902284)4.04190858
11paraxial mesoderm development (GO:0048339)4.02041453
12glomerular basement membrane development (GO:0032836)3.95069274
13hippo signaling (GO:0035329)3.77421309
14planar cell polarity pathway involved in neural tube closure (GO:0090179)3.76253429
15endothelial cell morphogenesis (GO:0001886)3.71067795
16COPI coating of Golgi vesicle (GO:0048205)3.70549392
17Golgi transport vesicle coating (GO:0048200)3.70549392
18endodermal cell differentiation (GO:0035987)3.70279385
19regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.61931566
20cell migration involved in heart development (GO:0060973)3.61771686
21polarized epithelial cell differentiation (GO:0030859)3.56510074
22regulation of hippo signaling (GO:0035330)3.55151684
23maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.52002961
24dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.49020463
25protein retention in ER lumen (GO:0006621)3.48522552
26protein localization to kinetochore (GO:0034501)3.47738272
27substrate-dependent cell migration (GO:0006929)3.45094896
28mesodermal cell differentiation (GO:0048333)3.42672720
29cell proliferation involved in metanephros development (GO:0072203)3.42137090
30retina vasculature morphogenesis in camera-type eye (GO:0061299)3.38744737
31negative regulation of epidermis development (GO:0045683)3.31852217
32negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.31617408
33nuclear pore complex assembly (GO:0051292)3.28451664
34basement membrane organization (GO:0071711)3.27683363
35polyketide metabolic process (GO:0030638)3.27604828
36doxorubicin metabolic process (GO:0044598)3.27604828
37daunorubicin metabolic process (GO:0044597)3.27604828
38regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.27180557
39focal adhesion assembly (GO:0048041)3.26984248
40cell-substrate adherens junction assembly (GO:0007045)3.26984248
41negative regulation of chondrocyte differentiation (GO:0032331)3.20181487
42regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.17850207
43heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.15360451
44kidney mesenchyme development (GO:0072074)3.14388310
45glomerular visceral epithelial cell development (GO:0072015)3.12980990
46metanephric mesenchyme development (GO:0072075)3.12839111
47negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.10339722
48skin morphogenesis (GO:0043589)3.03635603
49epithelial cell-cell adhesion (GO:0090136)3.02071683
50cochlea morphogenesis (GO:0090103)3.01557309
51cell adhesion mediated by integrin (GO:0033627)3.01477643
52extracellular fibril organization (GO:0043206)3.01293199
53apoptotic cell clearance (GO:0043277)3.00263618
54positive regulation of osteoblast proliferation (GO:0033690)3.00106913
55sequestering of extracellular ligand from receptor (GO:0035581)2.99686951
56branching involved in mammary gland duct morphogenesis (GO:0060444)2.99197279
57type B pancreatic cell proliferation (GO:0044342)2.98403319
58regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.98071895
59cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.98017140
60extracellular matrix assembly (GO:0085029)2.97908522
61plasma membrane repair (GO:0001778)2.97717260
62muscle cell migration (GO:0014812)2.95572695
63mesenchymal-epithelial cell signaling (GO:0060638)2.93519103
64positive regulation of endothelial cell apoptotic process (GO:2000353)2.93299451
65positive regulation of blood vessel endothelial cell migration (GO:0043536)2.93133189
66NLS-bearing protein import into nucleus (GO:0006607)2.93002115
67G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.92862679
68negative regulation of catenin import into nucleus (GO:0035414)2.92112541
69nuclear pore organization (GO:0006999)2.91587496
70collagen metabolic process (GO:0032963)2.90882238
71outer ear morphogenesis (GO:0042473)2.90133100
72regulation of mammary gland epithelial cell proliferation (GO:0033599)2.88810897
73wound healing, spreading of epidermal cells (GO:0035313)2.88276551
74epoxygenase P450 pathway (GO:0019373)2.87693876
75renal filtration (GO:0097205)2.87474742
76glomerular epithelial cell development (GO:0072310)2.87207805
77establishment of apical/basal cell polarity (GO:0035089)2.86589512
78protein localization to endosome (GO:0036010)2.86014737
79collagen catabolic process (GO:0030574)2.84167588
80wound healing, spreading of cells (GO:0044319)2.84115876
81negative regulation of fatty acid transport (GO:2000192)2.83811830
82craniofacial suture morphogenesis (GO:0097094)2.82365034
83regulation of SMAD protein import into nucleus (GO:0060390)2.81406827
84chondrocyte development (GO:0002063)2.81050815
85negative regulation of smooth muscle cell migration (GO:0014912)2.80820648
86atrioventricular valve morphogenesis (GO:0003181)2.78788592
87extracellular matrix organization (GO:0030198)2.78453260
88Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.77506169
89extracellular structure organization (GO:0043062)2.77309914
90chromatin assembly (GO:0031497)2.76922689
91multicellular organismal macromolecule metabolic process (GO:0044259)2.76829349
92regulation of posttranscriptional gene silencing (GO:0060147)2.76446860
93regulation of gene silencing by miRNA (GO:0060964)2.76446860
94regulation of gene silencing by RNA (GO:0060966)2.76446860
95positive regulation of smoothened signaling pathway (GO:0045880)2.76358277
96negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.76345657
97regulation of telomere maintenance via telomerase (GO:0032210)2.76133415
98primitive streak formation (GO:0090009)2.75961264
99bone morphogenesis (GO:0060349)2.75595223
100adherens junction assembly (GO:0034333)2.75554586
101protein hydroxylation (GO:0018126)2.75504698
102peptidyl-proline hydroxylation (GO:0019511)2.75476170
103regulation of transforming growth factor beta2 production (GO:0032909)2.75075314
104vascular endothelial growth factor signaling pathway (GO:0038084)2.74120728
105regulation of establishment of planar polarity (GO:0090175)2.73081872
106cell migration involved in sprouting angiogenesis (GO:0002042)2.72743510
107regulation of apoptotic process involved in morphogenesis (GO:1902337)2.72498716
108regulation of response to osmotic stress (GO:0047484)2.72090500
109negative regulation of axon extension involved in axon guidance (GO:0048843)2.71789844
110pre-miRNA processing (GO:0031054)2.71304529
111positive regulation of histone deacetylation (GO:0031065)2.70760413
112anterior/posterior axis specification, embryo (GO:0008595)2.70650078
113sister chromatid segregation (GO:0000819)2.70450039
114semaphorin-plexin signaling pathway (GO:0071526)2.69153218
115mitotic sister chromatid segregation (GO:0000070)2.69090178
116negative regulation of cartilage development (GO:0061037)2.68583746
117positive regulation of SMAD protein import into nucleus (GO:0060391)2.66531240
118blood vessel endothelial cell migration (GO:0043534)2.64972715
119negative regulation of cell cycle G2/M phase transition (GO:1902750)2.64677551
120cellular response to vitamin (GO:0071295)2.64601927
121muscle organ morphogenesis (GO:0048644)2.63640294
122cellular response to vitamin D (GO:0071305)2.63447651
123insulin-like growth factor receptor signaling pathway (GO:0048009)2.62653744
124vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.62584690
125stress fiber assembly (GO:0043149)2.62282683
126dermatan sulfate biosynthetic process (GO:0030208)2.61848615
127convergent extension (GO:0060026)2.61668785
128multicellular organismal catabolic process (GO:0044243)2.61205198
129substrate adhesion-dependent cell spreading (GO:0034446)2.60836382
130protein localization to cell surface (GO:0034394)2.60084088
131regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.58844472
132multicellular organismal metabolic process (GO:0044236)2.58077252
133glomerular filtration (GO:0003094)2.57588682
134regulation of cartilage development (GO:0061035)2.56979308
135barbed-end actin filament capping (GO:0051016)2.56946012
136establishment of tissue polarity (GO:0007164)2.55717731
137establishment of planar polarity (GO:0001736)2.55717731
138body morphogenesis (GO:0010171)2.55100189
139regulation of axon extension involved in axon guidance (GO:0048841)2.55076324
140RNA stabilization (GO:0043489)2.54925026
141mRNA stabilization (GO:0048255)2.54925026
142maintenance of protein location in nucleus (GO:0051457)2.54865473
143cell proliferation involved in kidney development (GO:0072111)2.54621701
144middle ear morphogenesis (GO:0042474)2.54596245
145extracellular matrix disassembly (GO:0022617)2.54164942
146dermatan sulfate metabolic process (GO:0030205)2.54009085
147embryonic camera-type eye development (GO:0031076)2.53616527
148heparan sulfate proteoglycan metabolic process (GO:0030201)2.53392152
149non-canonical Wnt signaling pathway (GO:0035567)2.52764913
150endocardial cushion development (GO:0003197)2.52675581
151regulation of chondrocyte differentiation (GO:0032330)2.52035843
152fibril organization (GO:0097435)2.52027951

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.28217971
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.28217971
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.28217971
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.89418628
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.62498197
6NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.87962311
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.79492571
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.74008603
9* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.69134420
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.66675353
11E2F7_22180533_ChIP-Seq_HELA_Human2.63659869
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.61320118
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.59872917
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.55684104
15RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.43094991
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.39182192
17TCF3_18692474_ChIP-Seq_MEFs_Mouse2.35216880
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.31663584
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.29063770
20SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.27311490
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.26754913
22ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.25595286
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.20656992
24WT1_19549856_ChIP-ChIP_CCG9911_Human2.10487234
25ZFP281_18757296_ChIP-ChIP_E14_Mouse2.07129689
26TCF3_18692474_ChIP-Seq_MESCs_Mouse1.99620213
27SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.97496450
28CLOCK_20551151_ChIP-Seq_293T_Human1.97324587
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.97115541
30ZNF263_19887448_ChIP-Seq_K562_Human1.94863990
31* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.92429796
32ZFP281_27345836_Chip-Seq_ESCs_Mouse1.88451702
33NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.82745669
34EP300_21415370_ChIP-Seq_HL-1_Mouse1.78893044
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.78033918
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.76295872
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.75153438
38NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.74104117
39HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.68341018
40* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.68111832
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.66666020
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.65951785
43BRD4_25478319_ChIP-Seq_HGPS_Human1.63193630
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61517369
45* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.59881055
46TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.59637311
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.55685508
48TP53_22127205_ChIP-Seq_IMR90_Human1.54498834
49* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.51150267
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.50806768
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50639226
52TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.45416119
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.45228182
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44294467
55EED_16625203_ChIP-ChIP_MESCs_Mouse1.42893753
56POU5F1_16518401_ChIP-PET_MESCs_Mouse1.39630111
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.35703533
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35420228
59NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.35245222
60TP53_18474530_ChIP-ChIP_U2OS_Human1.34638590
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33283689
62DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32715563
63* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.31704361
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31004900
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30841113
66AR_21909140_ChIP-Seq_LNCAP_Human1.30698310
67EZH2_18974828_ChIP-Seq_MESCs_Mouse1.29211570
68RNF2_18974828_ChIP-Seq_MESCs_Mouse1.29211570
69ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28316277
70KDM2B_26808549_Chip-Seq_K562_Human1.28166411
71FOXO3_23340844_ChIP-Seq_DLD1_Human1.26857000
72RACK7_27058665_Chip-Seq_MCF-7_Human1.26856742
73TBX20_22328084_ChIP-Seq_HEART_Mouse1.26773870
74TBX20_22080862_ChIP-Seq_HEART_Mouse1.26773870
75NFIB_24661679_ChIP-Seq_LUNG_Mouse1.26090238
76ATF3_27146783_Chip-Seq_COLON_Human1.25744123
77KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25335667
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25033230
79* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24912489
80SALL4_18804426_ChIP-ChIP_XEN_Mouse1.24234907
81FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.24179607
82JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23283624
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.22937464
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22715705
85NANOG_16153702_ChIP-ChIP_HESCs_Human1.22095427
86ESR1_21235772_ChIP-Seq_MCF-7_Human1.20352808
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19358359
88EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18681093
89* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.18505143
90E2F4_17652178_ChIP-ChIP_JURKAT_Human1.16912959
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16380296
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15298894
93ISL1_27105846_Chip-Seq_CPCs_Mouse1.14753181
94MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.14440741
95SA1_22415368_ChIP-Seq_MEFs_Mouse1.13834707
96NANOG_18692474_ChIP-Seq_MEFs_Mouse1.13033894
97SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11244582
98ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11223661
99CDX2_20551321_ChIP-Seq_CACO-2_Human1.10724921
100GATA2_21666600_ChIP-Seq_HMVEC_Human1.10554383
101SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10256417
102MYC_22102868_ChIP-Seq_BL_Human1.10147703
103* TP53_23651856_ChIP-Seq_MEFs_Mouse1.09995653
104LXR_22292898_ChIP-Seq_THP-1_Human1.09297180
105TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08657277
106FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08620742
107TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08084475
108TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07940254
109CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07878226
110RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07764322
111TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07247485
112UBF1/2_26484160_Chip-Seq_HMECs_Human1.07183743
113NCOR1_26117541_ChIP-Seq_K562_Human1.06750701
114JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05814912
115SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05558900
116STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05476610
117* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05261334
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05248586
119MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04981432
120FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04041481
121PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02849602
122NANOG_21062744_ChIP-ChIP_HESCs_Human1.02521385
123NANOG_18692474_ChIP-Seq_MESCs_Mouse1.02384727
124TP53_16413492_ChIP-PET_HCT116_Human1.02210961
125KDM2B_26808549_Chip-Seq_DND41_Human1.02100344
126TCF7_22412390_ChIP-Seq_EML_Mouse1.00932547
127* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00485127
128* CJUN_26792858_Chip-Seq_BT549_Human0.99921210
129RING1B_27294783_Chip-Seq_NPCs_Mouse0.99876278
130NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99745567
131NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99745567
132SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99469850
133SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99469850
134DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98665467
135NANOG_16518401_ChIP-PET_MESCs_Mouse0.98406795
136EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97954418
137* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97062702
138SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.95739302
139ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95372985
140POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.95327231

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.39274648
2MP0003705_abnormal_hypodermis_morpholog4.18464863
3MP0005275_abnormal_skin_tensile3.41826588
4MP0005503_abnormal_tendon_morphology3.33199795
5MP0004272_abnormal_basement_membrane2.99654383
6MP0005623_abnormal_meninges_morphology2.97337303
7MP0010030_abnormal_orbit_morphology2.89534011
8MP0005257_abnormal_intraocular_pressure2.62354018
9MP0010352_gastrointestinal_tract_polyps2.49692477
10MP0003279_aneurysm2.43396876
11MP0003283_abnormal_digestive_organ2.06456013
12MP0005508_abnormal_skeleton_morphology1.99476543
13MP0003122_maternal_imprinting1.94598125
14MP0003950_abnormal_plasma_membrane1.89281024
15MP0000751_myopathy1.85824255
16MP0003566_abnormal_cell_adhesion1.77506244
17MP0003385_abnormal_body_wall1.74715981
18MP0000428_abnormal_craniofacial_morphol1.71325832
19MP0002932_abnormal_joint_morphology1.70829958
20MP0000733_abnormal_muscle_development1.67547975
21MP0005023_abnormal_wound_healing1.65877252
22MP0009250_abnormal_appendicular_skeleto1.64158057
23MP0001958_emphysema1.59173387
24MP0003942_abnormal_urinary_system1.59025709
25MP0005171_absent_coat_pigmentation1.54822967
26MP0009053_abnormal_anal_canal1.53562565
27MP0003091_abnormal_cell_migration1.49607010
28MP0002877_abnormal_melanocyte_morpholog1.49183425
29MP0000049_abnormal_middle_ear1.46257652
30MP0003755_abnormal_palate_morphology1.45466322
31MP0000013_abnormal_adipose_tissue1.45187032
32MP0000537_abnormal_urethra_morphology1.45173552
33MP0001849_ear_inflammation1.45068121
34MP0002108_abnormal_muscle_morphology1.44866403
35MP0003935_abnormal_craniofacial_develop1.42666546
36MP0001542_abnormal_bone_strength1.41790880
37MP0000534_abnormal_ureter_morphology1.41493045
38MP0004858_abnormal_nervous_system1.39017331
39MP0009384_cardiac_valve_regurgitation1.38908813
40MP0003937_abnormal_limbs/digits/tail_de1.37329776
41MP0000579_abnormal_nail_morphology1.34758207
42MP0005076_abnormal_cell_differentiation1.34552894
43MP0006054_spinal_hemorrhage1.32528846
44MP0003121_genomic_imprinting1.31802210
45MP0000432_abnormal_head_morphology1.31698287
46MP0000762_abnormal_tongue_morphology1.30865319
47MP0003890_abnormal_embryonic-extraembry1.30829513
48MP0002233_abnormal_nose_morphology1.29787946
49MP0003123_paternal_imprinting1.28125699
50MP0002092_abnormal_eye_morphology1.26919492
51MP0002249_abnormal_larynx_morphology1.26844872
52MP0002060_abnormal_skin_morphology1.25590742
53MP0001293_anophthalmia1.24306055
54MP0004197_abnormal_fetal_growth/weight/1.23785823
55MP0000163_abnormal_cartilage_morphology1.22523863
56MP0001879_abnormal_lymphatic_vessel1.22272338
57MP0004264_abnormal_extraembryonic_tissu1.20121894
58MP0010368_abnormal_lymphatic_system1.19669710
59MP0005409_darkened_coat_color1.18647645
60MP0002116_abnormal_craniofacial_bone1.18535710
61MP0003011_delayed_dark_adaptation1.17180809
62MP0002088_abnormal_embryonic_growth/wei1.15485286
63MP0002254_reproductive_system_inflammat1.14485658
64MP0003984_embryonic_growth_retardation1.14427411
65MP0005380_embryogenesis_phenotype1.13980724
66MP0001672_abnormal_embryogenesis/_devel1.13980724
67MP0002896_abnormal_bone_mineralization1.13481516
68MP0000767_abnormal_smooth_muscle1.13408137
69MP0002697_abnormal_eye_size1.12906823
70MP0002282_abnormal_trachea_morphology1.12822154
71MP0001348_abnormal_lacrimal_gland1.11701005
72MP0002084_abnormal_developmental_patter1.11697514
73MP0002085_abnormal_embryonic_tissue1.11344726
74MP0003115_abnormal_respiratory_system1.11040702
75MP0000750_abnormal_muscle_regeneration1.10571552
76MP0009780_abnormal_chondrocyte_physiolo1.10523430
77MP0002925_abnormal_cardiovascular_devel1.10439145
78MP0005248_abnormal_Harderian_gland1.09849766
79MP0002114_abnormal_axial_skeleton1.08584439
80MP0001243_abnormal_dermal_layer1.08473871
81MP0005595_abnormal_vascular_smooth1.03511968
82MP0001299_abnormal_eye_distance/1.03116566
83MP0002653_abnormal_ependyma_morphology1.02751042
84MP0002111_abnormal_tail_morphology1.02463654
85MP0000003_abnormal_adipose_tissue1.01708509
86MP0000467_abnormal_esophagus_morphology1.01517991
87MP0002086_abnormal_extraembryonic_tissu1.00620291
88MP0003119_abnormal_digestive_system0.99356507
89MP0002109_abnormal_limb_morphology0.99259683
90MP0004233_abnormal_muscle_weight0.99133535
91MP0003941_abnormal_skin_development0.96994089
92MP0003045_fibrosis0.96102506
93MP0004185_abnormal_adipocyte_glucose0.95773509
94MP0000350_abnormal_cell_proliferation0.95656081
95MP0002115_abnormal_skeleton_extremities0.94617963
96MP0000462_abnormal_digestive_system0.93572482
97MP0002113_abnormal_skeleton_development0.89772860
98MP0000759_abnormal_skeletal_muscle0.88920352
99MP0004957_abnormal_blastocyst_morpholog0.88701574
100MP0001614_abnormal_blood_vessel0.88698826
101MP0003938_abnormal_ear_development0.88419873
102MP0002295_abnormal_pulmonary_circulatio0.88233510
103MP0006138_congestive_heart_failure0.88107807
104MP0005197_abnormal_uvea_morphology0.87961125
105MP0005499_abnormal_olfactory_system0.83495570
106MP0005394_taste/olfaction_phenotype0.83495570
107MP0005367_renal/urinary_system_phenotyp0.82839038
108MP0000516_abnormal_urinary_system0.82839038
109MP0000678_abnormal_parathyroid_gland0.82682586
110MP0005390_skeleton_phenotype0.81114126
111MP0002089_abnormal_postnatal_growth/wei0.80588009
112MP0001286_abnormal_eye_development0.79903716
113MP0004133_heterotaxia0.79610425
114MP0001915_intracranial_hemorrhage0.78936348
115MP0002128_abnormal_blood_circulation0.78203612
116MP0001697_abnormal_embryo_size0.78141186
117MP0005193_abnormal_anterior_eye0.78099685
118MP0002938_white_spotting0.77780606
119MP0000749_muscle_degeneration0.74412639
120MP0001661_extended_life_span0.73641819
121MP0004134_abnormal_chest_morphology0.72434851
122MP0003453_abnormal_keratinocyte_physiol0.72184622
123MP0002177_abnormal_outer_ear0.69163656
124MP0004087_abnormal_muscle_fiber0.68893749
125MP0010771_integument_phenotype0.62144822
126MP0001175_abnormal_lung_morphology0.61714902
127MP0008932_abnormal_embryonic_tissue0.61238490
128MP0005621_abnormal_cell_physiology0.61137256
129MP0004084_abnormal_cardiac_muscle0.60203231
130MP0003448_altered_tumor_morphology0.58584364

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.32616704
2Premature rupture of membranes (HP:0001788)5.83548885
3Ankle contracture (HP:0006466)4.34238772
4Shallow orbits (HP:0000586)4.07905906
5Vascular tortuosity (HP:0004948)4.05605006
6Arterial tortuosity (HP:0005116)3.87666309
7Peritonitis (HP:0002586)3.57490854
8Aortic dissection (HP:0002647)3.31231715
9Broad metatarsal (HP:0001783)3.31134094
10Increased connective tissue (HP:0009025)3.28086435
11Cerebral aneurysm (HP:0004944)3.23925836
12Atrophic scars (HP:0001075)3.23760142
13Soft skin (HP:0000977)3.08037138
14Bilateral microphthalmos (HP:0007633)3.05222134
15Cervical subluxation (HP:0003308)3.02514131
16Mitral valve prolapse (HP:0001634)3.00739607
17Genu recurvatum (HP:0002816)2.99727528
18Hepatoblastoma (HP:0002884)2.99221244
19Bladder diverticulum (HP:0000015)2.97242232
20Abnormality of dentin (HP:0010299)2.95781430
21Neonatal short-limb short stature (HP:0008921)2.91205316
22Wrist flexion contracture (HP:0001239)2.72459526
23Dilatation of the ascending aorta (HP:0005111)2.70786467
24Ulnar bowing (HP:0003031)2.70422008
25Fragile skin (HP:0001030)2.67679105
26Aortic aneurysm (HP:0004942)2.56912704
27Short 4th metacarpal (HP:0010044)2.56417396
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.56417396
29Mildly elevated creatine phosphokinase (HP:0008180)2.53676142
30Short nail (HP:0001799)2.51439815
31Renal duplication (HP:0000075)2.51411007
32Blue sclerae (HP:0000592)2.49070211
33Mesomelia (HP:0003027)2.48905959
34Fused cervical vertebrae (HP:0002949)2.45093928
35Spondylolisthesis (HP:0003302)2.42448011
36Spinal rigidity (HP:0003306)2.38639745
37Abnormality of the distal phalanx of the thumb (HP:0009617)2.29082354
38Bowel diverticulosis (HP:0005222)2.28637415
39Wormian bones (HP:0002645)2.27991642
40Natal tooth (HP:0000695)2.26094801
41Hyperacusis (HP:0010780)2.26060135
42Wide anterior fontanel (HP:0000260)2.24712157
43Deviation of the hallux (HP:0010051)2.23890228
44Follicular hyperkeratosis (HP:0007502)2.23370417
45Aortic regurgitation (HP:0001659)2.22266632
46Type 1 muscle fiber predominance (HP:0003803)2.19671406
47Disproportionate tall stature (HP:0001519)2.19037703
48Rib fusion (HP:0000902)2.18094705
49Hyperextensible skin (HP:0000974)2.17411779
50Radial bowing (HP:0002986)2.14761386
51Hallux valgus (HP:0001822)2.13413269
52Increased variability in muscle fiber diameter (HP:0003557)2.12351942
53Infantile muscular hypotonia (HP:0008947)2.10026835
54Distal upper limb amyotrophy (HP:0007149)2.08384852
55Upper limb amyotrophy (HP:0009129)2.08384852
56Abnormality of the 4th metacarpal (HP:0010012)2.08238171
57Short humerus (HP:0005792)2.07935440
58Lymphangioma (HP:0100764)2.07854653
59Ectopia lentis (HP:0001083)2.05618389
60Aneurysm (HP:0002617)2.05587985
61Selective tooth agenesis (HP:0001592)2.04639843
62Camptodactyly of toe (HP:0001836)2.03638681
63Astrocytoma (HP:0009592)2.03577953
64Abnormality of the astrocytes (HP:0100707)2.03577953
65Broad long bones (HP:0005622)2.02903034
66Mitral stenosis (HP:0001718)2.02103122
67Broad thumb (HP:0011304)1.99374995
68Multiple enchondromatosis (HP:0005701)1.98805701
69Buphthalmos (HP:0000557)1.98100730
70Coronal craniosynostosis (HP:0004440)1.96689167
71Biconcave vertebral bodies (HP:0004586)1.96428108
72Abnormality of the acetabulum (HP:0003170)1.95676734
73Bowed forearm bones (HP:0003956)1.94173125
74Bowing of the arm (HP:0006488)1.94173125
75Abnormality of the peritoneum (HP:0002585)1.93200370
76Aplasia/hypoplasia of the humerus (HP:0006507)1.92975547
77Vertebral compression fractures (HP:0002953)1.91208080
78Aortic valve stenosis (HP:0001650)1.90819433
79Difficulty running (HP:0009046)1.90426705
80Absent frontal sinuses (HP:0002688)1.89203805
81Short 5th finger (HP:0009237)1.89066567
82Broad face (HP:0000283)1.89063637
83Hypoventilation (HP:0002791)1.87920815
84Turricephaly (HP:0000262)1.87282315
85Ependymoma (HP:0002888)1.87024033
86Abnormality of the lower motor neuron (HP:0002366)1.85248541
87Delayed cranial suture closure (HP:0000270)1.84693091
88Hand muscle atrophy (HP:0009130)1.84371945
89Protruding ear (HP:0000411)1.84284063
90Mild short stature (HP:0003502)1.83924471
91Trismus (HP:0000211)1.83540516
92Broad toe (HP:0001837)1.83310086
93Dislocated radial head (HP:0003083)1.82062447
94Vertebral arch anomaly (HP:0008438)1.81602168
95Breech presentation (HP:0001623)1.81155244
96Abnormality of skeletal muscle fiber size (HP:0012084)1.79805001
97Mitral regurgitation (HP:0001653)1.79587830
98Broad phalanx (HP:0006009)1.78569050
99Tibial bowing (HP:0002982)1.78551687
100Abnormality of the radial head (HP:0003995)1.78135866
101Inguinal hernia (HP:0000023)1.77508781
102Pterygium (HP:0001059)1.76005900
103Joint laxity (HP:0001388)1.75449581
104Abnormality of the calcaneus (HP:0008364)1.75126470
105Abnormal delivery (HP:0001787)1.74746889
106Spinal cord lesions (HP:0100561)1.74380602
107Syringomyelia (HP:0003396)1.74380602
108Arnold-Chiari malformation (HP:0002308)1.74282092
109Coxa vara (HP:0002812)1.74113828
110Hypoplasia of the iris (HP:0007676)1.73875602
111Broad phalanges of the hand (HP:0009768)1.73764079
112Flat cornea (HP:0007720)1.72435843
113Overgrowth (HP:0001548)1.72376682
114Generalized amyotrophy (HP:0003700)1.72119247
115Long toe (HP:0010511)1.71789477
116Round ear (HP:0100830)1.71204717
117Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.70493960
118Thin bony cortex (HP:0002753)1.69502474
119Limb-girdle muscle weakness (HP:0003325)1.68987924
120Elbow flexion contracture (HP:0002987)1.67968923
121Preaxial foot polydactyly (HP:0001841)1.67906523
122Abnormality of skull ossification (HP:0002703)1.66953056
123Broad finger (HP:0001500)1.66934990
124Abnormal cartilage morphology (HP:0002763)1.66913495
125Joint stiffness (HP:0001387)1.66731567
126Slender build (HP:0001533)1.65135033
127Abnormal ossification of hand bones (HP:0005921)1.65075739
128Hip contracture (HP:0003273)1.64917110
129Abnormality of the phalanges of the hallux (HP:0010057)1.64745510
130Broad ribs (HP:0000885)1.64278503
131Abnormality of oral frenula (HP:0000190)1.64221423
132Distal lower limb amyotrophy (HP:0008944)1.64047923
133Osteolytic defects of the phalanges of the hand (HP:0009771)1.63891365
134Osteolytic defects of the hand bones (HP:0009699)1.63891365
135Achilles tendon contracture (HP:0001771)1.63825077
136Abnormality of the distal phalanges of the toes (HP:0010182)1.62547030
137Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.62026258
138Arachnodactyly (HP:0001166)1.60306440

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.80345661
2DDR23.54903944
3ERN13.44759765
4PDGFRA3.07114727
5TTN3.06529968
6TRIB32.98787486
7LATS12.85897100
8MYLK2.66065260
9MST1R2.64401406
10LATS22.47148952
11TGFBR22.23062860
12PAK42.03720827
13SIK12.01513417
14PKN21.91330846
15EPHA21.90218569
16EPHB21.90155645
17TYRO31.87567182
18ERBB41.83865345
19MAP3K101.83560556
20GRK51.81976964
21RIPK11.75265462
22NEK91.69343488
23BMX1.69046054
24MOS1.66455008
25PAK21.64239243
26TTK1.60344134
27TESK11.60155531
28LIMK11.59235576
29STK101.51743375
30SMG11.48712654
31PTK21.46904311
32EEF2K1.43810789
33MTOR1.43341945
34LMTK21.35539356
35WNK11.30679214
36CSF1R1.26524651
37EPHB11.24587243
38GRK61.23899331
39STK31.18085219
40CDK71.14320269
41NTRK11.14125644
42MAPK71.12056390
43ICK1.07343654
44FGFR11.05653595
45MET1.03102995
46PAK31.02593686
47CAMK1D0.99994891
48IRAK30.99062734
49PDGFRB0.96981401
50PTK60.96361762
51FER0.95691231
52FGFR30.92973848
53RPS6KA20.90668552
54CDK80.90468586
55MARK20.88832831
56GRK10.87374763
57FGFR40.87055778
58PRKG20.86656987
59MATK0.85357894
60MAP3K60.84770733
61LRRK20.81267738
62NEK20.79067031
63ADRBK10.77543191
64FGFR20.73260416
65DMPK0.72134156
66CAMK40.71826407
67ABL20.71752959
68AKT30.68849245
69STK38L0.68712080
70AKT20.68706696
71ALK0.68620502
72CHEK20.66019241
73PRKD20.64507923
74NEK10.64168458
75CDC70.63919089
76CDK60.62797261
77TRPM70.62540082
78ERBB20.62466094
79RPS6KB20.62405563
80PRKD30.62084259
81CAMK1G0.61677641
82CLK10.61102874
83PLK10.60337809
84INSR0.57565852
85TGFBR10.55844681
86PIM20.55422096
87TIE10.55029781
88MAP3K30.54222796
89CHEK10.53792771
90ROCK10.52230138
91ARAF0.52059964
92PAK10.51902428
93RPS6KA40.51538724
94MAP3K70.50661346
95DYRK1B0.50579397
96MAP3K80.49804195
97HIPK20.49634439
98CDK90.46492810
99PAK60.43951827
100ILK0.43718326
101ADRBK20.40991230
102EPHA30.40096211
103DAPK30.39590836
104MAPK10.39159812
105CDK40.38243995
106RPS6KC10.37714291
107RPS6KL10.37714291
108AURKB0.37146983
109GSK3A0.36524482
110BRSK10.36348843
111CDC42BPA0.35718193
112BRD40.35371803
113ROCK20.35345384
114CDK180.35201566
115CDK20.34748990
116CDK11A0.34743347
117KSR20.34530909
118STK380.34522829
119SRC0.34331210
120IGF1R0.33890077
121SCYL20.33830651
122FLT30.33783926
123CDK150.31239736
124PRKD10.29242222
125MAP2K10.28373467
126CAMK2G0.28337981
127PNCK0.27951073
128PTK2B0.27919087
129CSNK1E0.27901364
130MELK0.27578938
131CSK0.26900820
132CDK140.26519099
133BUB10.26153356
134KSR10.26047948
135PBK0.24648533
136PRPF4B0.24338712

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.72463193
2Focal adhesion_Homo sapiens_hsa045102.76076605
3Basal cell carcinoma_Homo sapiens_hsa052172.51800523
4Proteoglycans in cancer_Homo sapiens_hsa052052.37043470
5Adherens junction_Homo sapiens_hsa045202.35395275
6Hippo signaling pathway_Homo sapiens_hsa043902.30253443
7MicroRNAs in cancer_Homo sapiens_hsa052062.13254459
8Small cell lung cancer_Homo sapiens_hsa052222.12721777
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.11076074
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.11053940
11Hedgehog signaling pathway_Homo sapiens_hsa043402.10489264
12Bladder cancer_Homo sapiens_hsa052192.07196804
13Protein digestion and absorption_Homo sapiens_hsa049742.04348453
14Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.86895423
15TGF-beta signaling pathway_Homo sapiens_hsa043501.71903334
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.70180900
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.64887609
18mTOR signaling pathway_Homo sapiens_hsa041501.63829182
19Dilated cardiomyopathy_Homo sapiens_hsa054141.62639630
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.62025890
21Amoebiasis_Homo sapiens_hsa051461.60834039
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.55502781
23PI3K-Akt signaling pathway_Homo sapiens_hsa041511.55454656
24Regulation of actin cytoskeleton_Homo sapiens_hsa048101.54450740
25Pathways in cancer_Homo sapiens_hsa052001.46798210
26Chronic myeloid leukemia_Homo sapiens_hsa052201.43368639
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.43139200
28Tight junction_Homo sapiens_hsa045301.40946749
29p53 signaling pathway_Homo sapiens_hsa041151.39779913
30Melanoma_Homo sapiens_hsa052181.37901180
31Wnt signaling pathway_Homo sapiens_hsa043101.36321869
32Vitamin B6 metabolism_Homo sapiens_hsa007501.34526406
33Cell cycle_Homo sapiens_hsa041101.34272285
34Thyroid cancer_Homo sapiens_hsa052161.32562094
35Notch signaling pathway_Homo sapiens_hsa043301.31095748
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22670417
37Rap1 signaling pathway_Homo sapiens_hsa040151.20480476
38Axon guidance_Homo sapiens_hsa043601.17487186
39Pancreatic cancer_Homo sapiens_hsa052121.15992137
40Prion diseases_Homo sapiens_hsa050201.12588918
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.11521947
42Viral myocarditis_Homo sapiens_hsa054161.09588184
43Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09358652
44Glioma_Homo sapiens_hsa052141.09272582
45Prostate cancer_Homo sapiens_hsa052151.08440777
46Colorectal cancer_Homo sapiens_hsa052101.08342701
47HTLV-I infection_Homo sapiens_hsa051661.07572039
48N-Glycan biosynthesis_Homo sapiens_hsa005101.05113432
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04211636
50RNA transport_Homo sapiens_hsa030131.00032347
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98637539
52Endometrial cancer_Homo sapiens_hsa052130.98344860
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91602434
54Non-small cell lung cancer_Homo sapiens_hsa052230.89997471
55mRNA surveillance pathway_Homo sapiens_hsa030150.88144957
56AMPK signaling pathway_Homo sapiens_hsa041520.87481501
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85911932
58Fructose and mannose metabolism_Homo sapiens_hsa000510.84041859
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83537685
60Lysine degradation_Homo sapiens_hsa003100.82704527
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82369860
62Melanogenesis_Homo sapiens_hsa049160.81803905
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80031518
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.79870495
65Renal cell carcinoma_Homo sapiens_hsa052110.79209376
66Malaria_Homo sapiens_hsa051440.78105729
67Viral carcinogenesis_Homo sapiens_hsa052030.77633704
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76587567
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75286861
70Other glycan degradation_Homo sapiens_hsa005110.74370913
71Galactose metabolism_Homo sapiens_hsa000520.71192541
72VEGF signaling pathway_Homo sapiens_hsa043700.69589023
73Pentose phosphate pathway_Homo sapiens_hsa000300.68906820
74One carbon pool by folate_Homo sapiens_hsa006700.67423724
75Acute myeloid leukemia_Homo sapiens_hsa052210.67142446
76Platelet activation_Homo sapiens_hsa046110.67035323
77HIF-1 signaling pathway_Homo sapiens_hsa040660.66739784
78Ovarian steroidogenesis_Homo sapiens_hsa049130.66197185
79Vibrio cholerae infection_Homo sapiens_hsa051100.65892567
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.63467094
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62842141
82Toxoplasmosis_Homo sapiens_hsa051450.61264478
83Biosynthesis of amino acids_Homo sapiens_hsa012300.60939364
84Renin-angiotensin system_Homo sapiens_hsa046140.59995308
85Gap junction_Homo sapiens_hsa045400.58251685
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57088317
87Ras signaling pathway_Homo sapiens_hsa040140.56880059
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56664792
89Thyroid hormone synthesis_Homo sapiens_hsa049180.56342476
90Insulin resistance_Homo sapiens_hsa049310.54998769
91Apoptosis_Homo sapiens_hsa042100.54231296
92Choline metabolism in cancer_Homo sapiens_hsa052310.53208507
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52178749
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52039347
95Estrogen signaling pathway_Homo sapiens_hsa049150.49625530
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.49479847
97Dorso-ventral axis formation_Homo sapiens_hsa043200.48797872
98Arachidonic acid metabolism_Homo sapiens_hsa005900.48414434
99GnRH signaling pathway_Homo sapiens_hsa049120.47737845
100ErbB signaling pathway_Homo sapiens_hsa040120.47391551
101Shigellosis_Homo sapiens_hsa051310.47159830
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46802757
103Salmonella infection_Homo sapiens_hsa051320.44876899
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43777576
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.42292173
106MAPK signaling pathway_Homo sapiens_hsa040100.40271563
107FoxO signaling pathway_Homo sapiens_hsa040680.39953013
108Endocytosis_Homo sapiens_hsa041440.39534351
109Hepatitis B_Homo sapiens_hsa051610.39492007
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39128463
111Insulin signaling pathway_Homo sapiens_hsa049100.38862838
112Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37685537
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.37249913
114Sphingolipid metabolism_Homo sapiens_hsa006000.36586155
115Glucagon signaling pathway_Homo sapiens_hsa049220.34940814
116Inositol phosphate metabolism_Homo sapiens_hsa005620.34047955
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30300523
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29673979

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