KISS1R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty. Mutations in this gene have been associated with hypogonadotropic hypogonadism and central precocious puberty. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.87960448
2ribosomal small subunit biogenesis (GO:0042274)6.80550010
3translational termination (GO:0006415)6.47592236
4translational elongation (GO:0006414)5.45948646
5synaptic vesicle maturation (GO:0016188)5.45486985
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.42412953
7locomotory exploration behavior (GO:0035641)5.28739810
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.22793720
9protein targeting to ER (GO:0045047)5.18848692
10cotranslational protein targeting to membrane (GO:0006613)5.17294893
11heterochromatin organization (GO:0070828)5.09541100
12viral life cycle (GO:0019058)5.06600318
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.97739123
14ATP synthesis coupled proton transport (GO:0015986)4.96070559
15energy coupled proton transport, down electrochemical gradient (GO:0015985)4.96070559
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.94247842
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.93323064
18cellular protein complex disassembly (GO:0043624)4.83251368
19protein localization to endoplasmic reticulum (GO:0070972)4.76270953
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.74814571
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.73928878
22proline metabolic process (GO:0006560)4.64863181
23regulation of synaptic vesicle exocytosis (GO:2000300)4.60145382
24layer formation in cerebral cortex (GO:0021819)4.51953327
25protein complex disassembly (GO:0043241)4.50157046
26vocalization behavior (GO:0071625)4.47967081
27glutamate secretion (GO:0014047)4.44179778
28synaptic vesicle exocytosis (GO:0016079)4.44127922
29establishment of protein localization to mitochondrial membrane (GO:0090151)4.43364336
30synaptic vesicle docking involved in exocytosis (GO:0016081)4.37423571
31translational initiation (GO:0006413)4.24213390
32macromolecular complex disassembly (GO:0032984)4.13656047
33regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.09954749
34regulation of synaptic vesicle transport (GO:1902803)3.97635180
35cell-cell junction maintenance (GO:0045217)3.93712540
36protein localization to synapse (GO:0035418)3.92475021
37exploration behavior (GO:0035640)3.87276432
38respiratory electron transport chain (GO:0022904)3.86499709
39regulation of glutamate receptor signaling pathway (GO:1900449)3.85856896
40proline transport (GO:0015824)3.85795996
41neurotransmitter secretion (GO:0007269)3.80301545
42sodium ion export (GO:0071436)3.76130129
43G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.75155172
44ribosomal small subunit assembly (GO:0000028)3.73402778
45activation of protein kinase A activity (GO:0034199)3.73358623
46ionotropic glutamate receptor signaling pathway (GO:0035235)3.70305653
47L-serine metabolic process (GO:0006563)3.69760344
48serine family amino acid biosynthetic process (GO:0009070)3.69757018
49electron transport chain (GO:0022900)3.69574565
50branching involved in labyrinthine layer morphogenesis (GO:0060670)3.68254821
51mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.61783823
52regulation of long-term neuronal synaptic plasticity (GO:0048169)3.61574972
53positive regulation of vesicle fusion (GO:0031340)3.59032719
54regulation of synapse structural plasticity (GO:0051823)3.57457413
55regulation of neuronal synaptic plasticity (GO:0048168)3.54106741
56neuron maturation (GO:0042551)3.52540958
57negative regulation of catecholamine secretion (GO:0033604)3.50621451
58gamma-aminobutyric acid transport (GO:0015812)3.44893852
59synaptic transmission, dopaminergic (GO:0001963)3.42367520
60cellular potassium ion homeostasis (GO:0030007)3.41675810
61diaphragm development (GO:0060539)3.41330358
62substrate-independent telencephalic tangential migration (GO:0021826)3.39736905
63substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.39736905
64protein targeting to membrane (GO:0006612)3.37824045
65dendritic spine morphogenesis (GO:0060997)3.37722845
66cellular response to nicotine (GO:0071316)3.36848239
67negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.36152610
68cellular modified amino acid catabolic process (GO:0042219)3.34542008
69maturation of SSU-rRNA (GO:0030490)3.34476143
70adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.33459222
71kinetochore assembly (GO:0051382)3.33284770
72glucose 6-phosphate metabolic process (GO:0051156)3.32822260
73regulation of ARF protein signal transduction (GO:0032012)3.31404434
74peristalsis (GO:0030432)3.26429431
75positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.24003855
76neuromuscular process controlling balance (GO:0050885)3.23911799
77positive regulation of synapse maturation (GO:0090129)3.22471122
78translation (GO:0006412)3.21627042
79cytoskeletal anchoring at plasma membrane (GO:0007016)3.20121836
804-hydroxyproline metabolic process (GO:0019471)3.20064318
81regulation of vesicle fusion (GO:0031338)3.19163096
82chaperone-mediated protein transport (GO:0072321)3.16974427
83proline biosynthetic process (GO:0006561)3.15798050
84positive regulation of membrane potential (GO:0045838)3.14122904
85neurotransmitter-gated ion channel clustering (GO:0072578)3.11340666
86response to histamine (GO:0034776)3.10958185
87cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.09865734
88ATP biosynthetic process (GO:0006754)3.09115044
89kinetochore organization (GO:0051383)3.07937935
90glutamate receptor signaling pathway (GO:0007215)3.07491295
91synaptic transmission, glutamatergic (GO:0035249)3.06452294
92regulation of clathrin-mediated endocytosis (GO:2000369)3.05705704
93positive regulation of p38MAPK cascade (GO:1900745)3.05346929
94negative regulation of microtubule polymerization (GO:0031115)3.04816447
95regulation of synaptic plasticity (GO:0048167)3.03846362
96regulation of dendritic spine morphogenesis (GO:0061001)3.03562273
97cell migration in hindbrain (GO:0021535)3.03264534
98neuron cell-cell adhesion (GO:0007158)3.02599014
99synaptic vesicle endocytosis (GO:0048488)3.02007822
100positive regulation of fibroblast migration (GO:0010763)3.01524235
101long-term memory (GO:0007616)3.00587341
102ribosomal large subunit biogenesis (GO:0042273)3.00032639
103skeletal muscle organ development (GO:0060538)2.99240657
104regulation of norepinephrine secretion (GO:0014061)2.99114541
105negative regulation of myeloid cell apoptotic process (GO:0033033)2.98880406
106vesicle transport along microtubule (GO:0047496)2.98655561
107neuronal action potential propagation (GO:0019227)2.98161971
108cellular response to virus (GO:0098586)2.97227373
109regulation of excitatory postsynaptic membrane potential (GO:0060079)2.96180585
110very-low-density lipoprotein particle assembly (GO:0034379)2.94458539
111positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.93076925
112regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.93066631
113histone H3-K9 demethylation (GO:0033169)2.92879342
114negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.92488233
115purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.92403564
116glycine transport (GO:0015816)2.91429331
117nuclear-transcribed mRNA catabolic process (GO:0000956)2.90705672
118neurotransmitter transport (GO:0006836)2.89265367
119inner mitochondrial membrane organization (GO:0007007)2.87153585
120cell communication by electrical coupling (GO:0010644)2.86961165
121cerebellar Purkinje cell layer development (GO:0021680)2.86866085
122regulation of female receptivity (GO:0045924)2.86461738
123purine nucleoside triphosphate biosynthetic process (GO:0009145)2.86351359
124neuron-neuron synaptic transmission (GO:0007270)2.83372233
125response to inactivity (GO:0014854)2.83023022
126regulation of ARF GTPase activity (GO:0032312)2.82752103
127long-term synaptic potentiation (GO:0060291)2.82618067
128positive regulation of protein kinase C signaling (GO:0090037)2.82239393
129mRNA catabolic process (GO:0006402)2.81483318
130chromatin assembly (GO:0031497)2.81249009
131organelle transport along microtubule (GO:0072384)2.80261926
132positive regulation of neurotransmitter transport (GO:0051590)2.80256505
133regulation of neurotransmitter levels (GO:0001505)2.80238278
134plasma lipoprotein particle assembly (GO:0034377)2.80031670
135negative regulation of synaptic transmission, GABAergic (GO:0032229)2.79743390
136genetic imprinting (GO:0071514)2.79669587
137protein localization to endosome (GO:0036010)2.79398727
138regulation of cellular respiration (GO:0043457)2.78951755
139positive regulation of lymphocyte apoptotic process (GO:0070230)2.78395957
140establishment of nucleus localization (GO:0040023)2.78249318
141cerebellar Purkinje cell differentiation (GO:0021702)2.77477659
142positive regulation of sodium ion transport (GO:0010765)2.76323277
143ribonucleoside triphosphate biosynthetic process (GO:0009201)2.75813575
144regulation of postsynaptic membrane potential (GO:0060078)2.74521026
145regulation of neurotransmitter secretion (GO:0046928)2.73893277
146prepulse inhibition (GO:0060134)2.72073828
147clathrin coat assembly (GO:0048268)2.70599012
148activation of MAPKKK activity (GO:0000185)2.69348592
149RNA catabolic process (GO:0006401)2.68625410
150dendrite morphogenesis (GO:0048813)2.68473536
151DNA replication checkpoint (GO:0000076)2.67581634
152intraspecies interaction between organisms (GO:0051703)2.66977764
153social behavior (GO:0035176)2.66977764
154negative regulation of DNA-templated transcription, elongation (GO:0032785)2.66873075
155regulation of early endosome to late endosome transport (GO:2000641)2.65536717
156positive regulation of catecholamine secretion (GO:0033605)2.64813898
157positive regulation of protein homooligomerization (GO:0032464)2.64600132
158modulation by symbiont of host cellular process (GO:0044068)2.64527986
159membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.63514287
160negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.63284916
161oxidative phosphorylation (GO:0006119)2.61872273
162positive regulation of T cell apoptotic process (GO:0070234)2.61366400
163DNA damage response, detection of DNA damage (GO:0042769)2.61266064
164regulation of dendritic spine development (GO:0060998)2.58755688
165alanine transport (GO:0032328)2.57075817
166ribonucleoprotein complex biogenesis (GO:0022613)2.56135452
167post-embryonic morphogenesis (GO:0009886)2.55211193
168regulation of neurotransmitter transport (GO:0051588)2.55156417
169cell junction maintenance (GO:0034331)2.54559489
170regulation of vitamin D biosynthetic process (GO:0060556)2.54314670
171negative regulation of norepinephrine secretion (GO:0010700)2.54019003
172membrane repolarization during action potential (GO:0086011)2.53431398
173negative regulation of amine transport (GO:0051953)2.53095632
174negative regulation of cell killing (GO:0031342)2.52725324
175negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.52725324
176long term synaptic depression (GO:0060292)2.52478496
177dendritic spine organization (GO:0097061)2.52456911
178neuromuscular process controlling posture (GO:0050884)2.52427027
179innervation (GO:0060384)2.51105060
180axon cargo transport (GO:0008088)2.50675999
181nerve growth factor signaling pathway (GO:0038180)2.50607642
182positive regulation of heat generation (GO:0031652)2.49995463
183body morphogenesis (GO:0010171)2.49981584
184regulation of amyloid precursor protein catabolic process (GO:1902991)2.48960084
185cerebellar granule cell differentiation (GO:0021707)2.48251635
186modulation by virus of host process (GO:0019054)2.47223207
187establishment of protein localization to membrane (GO:0090150)2.47135535
188UTP biosynthetic process (GO:0006228)2.47116605
189histone H3-K9 methylation (GO:0051567)2.45426026
190neuron recognition (GO:0008038)2.45367228
191dopamine receptor signaling pathway (GO:0007212)2.45135543
192phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.44934813
193positive regulation of cellular amine metabolic process (GO:0033240)2.44906101
194neuromuscular process (GO:0050905)2.44809172
195positive regulation of neurotransmitter secretion (GO:0001956)2.44237797
196positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.44135876
197protein targeting to plasma membrane (GO:0072661)2.44100180
198positive regulation of axon extension (GO:0045773)2.43312860
199* regulation of synaptic transmission (GO:0050804)2.42925535

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.65823723
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.35559323
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.84817868
4MYC_18555785_ChIP-Seq_MESCs_Mouse2.83222784
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.78440572
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.77285906
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.69714001
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.68556707
9DROSHA_22980978_ChIP-Seq_HELA_Human2.53600855
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.36663254
11MYC_22102868_ChIP-Seq_BL_Human2.34675931
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32975669
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.31299579
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28113756
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25864698
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25373865
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24552527
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24552527
19REST_21632747_ChIP-Seq_MESCs_Mouse2.24361891
20XRN2_22483619_ChIP-Seq_HELA_Human2.21894381
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.20751312
22E2F7_22180533_ChIP-Seq_HELA_Human2.15718831
23JARID2_20064375_ChIP-Seq_MESCs_Mouse2.13378240
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.12552991
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.12448939
26KDM2B_26808549_Chip-Seq_K562_Human2.12089637
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.09652769
28KDM2B_26808549_Chip-Seq_SUP-B15_Human2.03244855
29* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.00655571
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.98155081
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96281561
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.94784364
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.93662205
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.93400127
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91448854
36* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90361896
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89459266
38VDR_21846776_ChIP-Seq_THP-1_Human1.89357149
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.87034430
40* EZH2_27294783_Chip-Seq_ESCs_Mouse1.83550143
41LXR_22292898_ChIP-Seq_THP-1_Human1.82559176
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81892874
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.81190070
44* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.79855763
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78571087
46KDM2B_26808549_Chip-Seq_DND41_Human1.77718911
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.76669714
48SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.75760149
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74612999
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.70923708
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.70838553
52* RNF2_27304074_Chip-Seq_ESCs_Mouse1.68258122
53* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.67754794
54SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.67333355
55GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.66594651
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66483060
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.64415283
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.63549883
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.61483687
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.60196565
61DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.60181604
62JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.59722783
63CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58792006
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.57824054
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57019540
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55239835
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.54165847
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52651477
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51522642
70AR_21572438_ChIP-Seq_LNCaP_Human1.49288303
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48134198
72ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.48077506
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.43499953
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41788065
75* KDM2B_26808549_Chip-Seq_JURKAT_Human1.41618862
76CREB1_15753290_ChIP-ChIP_HEK293T_Human1.41064545
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39272117
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.38229691
79EST1_17652178_ChIP-ChIP_JURKAT_Human1.36832113
80KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.35493283
81GBX2_23144817_ChIP-Seq_PC3_Human1.34642973
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34207034
83TP63_17297297_ChIP-ChIP_HaCaT_Human1.33183102
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32864418
85E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32332972
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31964092
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30279660
88ZNF263_19887448_ChIP-Seq_K562_Human1.29987671
89TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.29371155
90EED_16625203_ChIP-ChIP_MESCs_Mouse1.29062774
91DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28792399
92TTF2_22483619_ChIP-Seq_HELA_Human1.28779478
93TET1_21490601_ChIP-Seq_MESCs_Mouse1.28764687
94ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28628614
95SMC4_20622854_ChIP-Seq_HELA_Human1.28560837
96CTCF_18555785_ChIP-Seq_MESCs_Mouse1.26739532
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26732817
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25778259
99CREB1_26743006_Chip-Seq_LNCaP_Human1.25463874
100SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24749272
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24671851
102P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24423204
103RACK7_27058665_Chip-Seq_MCF-7_Human1.24249967
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.24000315
105NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23715579
106* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23708488
107ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23519883
108FOXP1_21924763_ChIP-Seq_HESCs_Human1.23039665
109CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22989748
110GABP_19822575_ChIP-Seq_HepG2_Human1.22353613
111RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21907229
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21746750
113TP63_19390658_ChIP-ChIP_HaCaT_Human1.21349548
114KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21146754
115KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21146754
116KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21146754
117ZNF274_21170338_ChIP-Seq_K562_Hela1.20893350
118SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20866382
119KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20714962
120CTCF_27219007_Chip-Seq_Bcells_Human1.20241746
121KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19823861
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19560473
123MAF_26560356_Chip-Seq_TH2_Human1.15586492
124KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15113406
125ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13912313
126NCOR1_26117541_ChIP-Seq_K562_Human1.11519692
127SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.10961549
128TCF7_22412390_ChIP-Seq_EML_Mouse1.10903695
129GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.09425783
130BP1_19119308_ChIP-ChIP_Hs578T_Human1.08375607
131KLF4_19829295_ChIP-Seq_ESCs_Human1.08162851
132* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08103535
133CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07358877
134NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06754308
135PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06093544
136CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05295738
137SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05215010
138RARA_24833708_ChIP-Seq_LIVER_Mouse1.05139752
139AHR_22903824_ChIP-Seq_MCF-7_Human1.05031299
140CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05019460
141TP53_20018659_ChIP-ChIP_R1E_Mouse1.04716449
142CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04597919
143* RING1B_27294783_Chip-Seq_ESCs_Mouse1.04516979
144ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03452936
145SMAD4_21741376_ChIP-Seq_ESCs_Human1.02994167
146AR_19668381_ChIP-Seq_PC3_Human1.02209825
147NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01442812
148SOX2_21211035_ChIP-Seq_LN229_Gbm1.00467190
149RUNX1_27514584_Chip-Seq_MCF-7_Human1.00370849
150RXR_22108803_ChIP-Seq_LS180_Human1.00337603
151NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00073878
152ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99840737
153ELK3_25401928_ChIP-Seq_HUVEC_Human0.99181495
154RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98691741
155GATA1_19941826_ChIP-Seq_K562_Human0.97960575
156SPI1_23127762_ChIP-Seq_K562_Human0.97617875
157OCT4_19829295_ChIP-Seq_ESCs_Human0.97401899
158* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97378993
159KLF5_25053715_ChIP-Seq_YYC3_Human0.95313339
160P68_20966046_ChIP-Seq_HELA_Human0.95211396
161RING1B_27294783_Chip-Seq_NPCs_Mouse0.93931304
162* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92475423
163CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91791819
164CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90802812
165CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87879091
166ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87404408
167NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86566082
168TP63_22573176_ChIP-Seq_HFKS_Human0.86541964
169ATF3_27146783_Chip-Seq_COLON_Human0.86541899
170SMAD3_21741376_ChIP-Seq_ESCs_Human0.86159808
171ARNT_22903824_ChIP-Seq_MCF-7_Human0.85600180
172ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84448213
173SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83897910
174* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.83514554

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting7.08595953
2MP0004859_abnormal_synaptic_plasticity6.34259763
3MP0010234_abnormal_vibrissa_follicle4.56489236
4MP0003787_abnormal_imprinting4.23054468
5MP0003635_abnormal_synaptic_transmissio3.68351777
6MP0002163_abnormal_gland_morphology3.33054990
7MP0000566_synostosis3.32414157
8MP0004270_analgesia3.26418574
9MP0004858_abnormal_nervous_system3.25924113
10MP0005377_hearing/vestibular/ear_phenot3.02492350
11MP0003878_abnormal_ear_physiology3.02492350
12MP0009780_abnormal_chondrocyte_physiolo2.92975553
13MP0002063_abnormal_learning/memory/cond2.86476460
14MP0003329_amyloid_beta_deposits2.84760269
15MP0009745_abnormal_behavioral_response2.61339088
16MP0003880_abnormal_central_pattern2.56715284
17MP0002909_abnormal_adrenal_gland2.50066409
18MP0001968_abnormal_touch/_nociception2.49908790
19MP0003122_maternal_imprinting2.44989267
20MP0002064_seizures2.39992342
21MP0005451_abnormal_body_composition2.38703865
22MP0003121_genomic_imprinting2.29524668
23MP0009046_muscle_twitch2.25264589
24MP0001188_hyperpigmentation2.18154429
25MP0000013_abnormal_adipose_tissue2.14745599
26MP0002837_dystrophic_cardiac_calcinosis2.14665681
27MP0001529_abnormal_vocalization2.13454622
28MP0002572_abnormal_emotion/affect_behav2.10796726
29MP0003303_peritoneal_inflammation2.08894744
30MP0002736_abnormal_nociception_after2.05472998
31MP0001440_abnormal_grooming_behavior2.04967601
32MP0002733_abnormal_thermal_nociception2.02110891
33MP0002734_abnormal_mechanical_nocicepti2.00773645
34MP0008961_abnormal_basal_metabolism2.00218848
35MP0002735_abnormal_chemical_nociception1.99650569
36MP0009379_abnormal_foot_pigmentation1.95081168
37MP0004742_abnormal_vestibular_system1.90480206
38MP0003879_abnormal_hair_cell1.84815093
39MP0001970_abnormal_pain_threshold1.84729631
40MP0005379_endocrine/exocrine_gland_phen1.79055933
41MP0004811_abnormal_neuron_physiology1.77407262
42MP0002272_abnormal_nervous_system1.74311983
43MP0005423_abnormal_somatic_nervous1.73398876
44MP0000678_abnormal_parathyroid_gland1.69583702
45MP0001486_abnormal_startle_reflex1.67317577
46MP0008569_lethality_at_weaning1.66397781
47MP0006292_abnormal_olfactory_placode1.65585429
48MP0001501_abnormal_sleep_pattern1.64617818
49MP0002638_abnormal_pupillary_reflex1.64459372
50MP0005167_abnormal_blood-brain_barrier1.61881801
51MP0005646_abnormal_pituitary_gland1.59692534
52MP0002822_catalepsy1.53170772
53MP0000604_amyloidosis1.47912175
54MP0003195_calcinosis1.47415043
55MP0003075_altered_response_to1.46298878
56MP0002184_abnormal_innervation1.45121679
57MP0004185_abnormal_adipocyte_glucose1.43883408
58MP0001485_abnormal_pinna_reflex1.41745154
59MP0010030_abnormal_orbit_morphology1.40057193
60MP0003633_abnormal_nervous_system1.39779437
61MP0005360_urolithiasis1.39494769
62MP0000579_abnormal_nail_morphology1.35308272
63MP0003941_abnormal_skin_development1.35069400
64* MP0000955_abnormal_spinal_cord1.34778782
65MP0003942_abnormal_urinary_system1.34216539
66MP0003705_abnormal_hypodermis_morpholog1.34040472
67MP0000003_abnormal_adipose_tissue1.32924063
68MP0004130_abnormal_muscle_cell1.31603899
69MP0004885_abnormal_endolymph1.29251605
70MP0005645_abnormal_hypothalamus_physiol1.26782930
71MP0001293_anophthalmia1.25533934
72MP0002067_abnormal_sensory_capabilities1.25022375
73MP0000778_abnormal_nervous_system1.24047656
74MP0008874_decreased_physiological_sensi1.21839727
75MP0005058_abnormal_lysosome_morphology1.18936494
76MP0003045_fibrosis1.18035847
77MP0003567_abnormal_fetal_cardiomyocyte1.15851026
78MP0003172_abnormal_lysosome_physiology1.15388758
79MP0002066_abnormal_motor_capabilities/c1.12178380
80MP0003631_nervous_system_phenotype1.10727319
81* MP0002557_abnormal_social/conspecific_i1.10124575
82MP0003186_abnormal_redox_activity1.10063766
83MP0003011_delayed_dark_adaptation1.08178125
84MP0005084_abnormal_gallbladder_morpholo1.07919809
85MP0008995_early_reproductive_senescence1.07703025
86MP0002877_abnormal_melanocyte_morpholog1.07212972
87MP0005375_adipose_tissue_phenotype1.06828301
88MP0004019_abnormal_vitamin_homeostasis1.05462626
89MP0002249_abnormal_larynx_morphology1.04210796
90MP0008058_abnormal_DNA_repair1.03358134
91MP0004233_abnormal_muscle_weight1.02631483
92MP0003938_abnormal_ear_development1.02023840
93MP0005386_behavior/neurological_phenoty1.00286352
94MP0004924_abnormal_behavior1.00286352
95MP0005623_abnormal_meninges_morphology0.99654344
96* MP0002882_abnormal_neuron_morphology0.99175159
97MP0003183_abnormal_peptide_metabolism0.98187537
98MP0008875_abnormal_xenobiotic_pharmacok0.97750713
99MP0003634_abnormal_glial_cell0.97234815
100MP0004957_abnormal_blastocyst_morpholog0.96503986
101MP0002796_impaired_skin_barrier0.96210725
102MP0002697_abnormal_eye_size0.93997699
103MP0001348_abnormal_lacrimal_gland0.93965870
104MP0002089_abnormal_postnatal_growth/wei0.92272643
105* MP0001919_abnormal_reproductive_system0.92113618
106MP0002139_abnormal_hepatobiliary_system0.91849650
107* MP0003315_abnormal_perineum_morphology0.89540325
108MP0005666_abnormal_adipose_tissue0.89344647
109MP0003693_abnormal_embryo_hatching0.87236596
110MP0000026_abnormal_inner_ear0.85575965
111MP0002069_abnormal_eating/drinking_beha0.85514487
112MP0001177_atelectasis0.85078172
113MP0003300_gastrointestinal_ulcer0.85049214
114MP0001299_abnormal_eye_distance/0.83743240
115MP0008872_abnormal_physiological_respon0.82070393
116MP0010678_abnormal_skin_adnexa0.81529865
117MP0005076_abnormal_cell_differentiation0.81492451
118* MP0002152_abnormal_brain_morphology0.81175931
119MP0002693_abnormal_pancreas_physiology0.80809348
120MP0001944_abnormal_pancreas_morphology0.77873745
121MP0001663_abnormal_digestive_system0.77478461
122MP0002938_white_spotting0.77451584
123MP0000747_muscle_weakness0.76985510
124MP0000920_abnormal_myelination0.76075157
125MP0005166_decreased_susceptibility_to0.76037947
126MP0001502_abnormal_circadian_rhythm0.75944334
127MP0001764_abnormal_homeostasis0.75696634
128MP0009278_abnormal_bone_marrow0.74052469
129MP0006276_abnormal_autonomic_nervous0.73086670
130MP0005535_abnormal_body_temperature0.72312859
131MP0003632_abnormal_nervous_system0.71415120
132MP0005083_abnormal_biliary_tract0.71411658
133MP0005275_abnormal_skin_tensile0.70777369
134MP0005409_darkened_coat_color0.70240452
135MP0003690_abnormal_glial_cell0.68593416
136MP0001664_abnormal_digestion0.68115180
137MP0005220_abnormal_exocrine_pancreas0.68085910
138MP0004484_altered_response_of0.67963669
139MP0005636_abnormal_mineral_homeostasis0.67925613
140MP0002229_neurodegeneration0.65509415
141MP0003453_abnormal_keratinocyte_physiol0.65100626
142MP0004510_myositis0.64268975
143MP0001963_abnormal_hearing_physiology0.63827817
144MP0005670_abnormal_white_adipose0.63121484
145MP0004133_heterotaxia0.62793540
146MP0004883_abnormal_blood_vessel0.62377735
147MP0005332_abnormal_amino_acid0.62025992
148MP0003119_abnormal_digestive_system0.61931392
149MP0009840_abnormal_foam_cell0.60564206
150MP0003191_abnormal_cellular_cholesterol0.60299136
151MP0003111_abnormal_nucleus_morphology0.59555851
152MP0002752_abnormal_somatic_nervous0.59011110
153MP0003436_decreased_susceptibility_to0.58932688
154MP0004085_abnormal_heartbeat0.58820865
155MP0001765_abnormal_ion_homeostasis0.58117370
156MP0003566_abnormal_cell_adhesion0.58065513
157MP0002234_abnormal_pharynx_morphology0.57703899
158MP0000631_abnormal_neuroendocrine_gland0.57512764
159MP0009333_abnormal_splenocyte_physiolog0.57440985
160MP0004043_abnormal_pH_regulation0.57153633
161MP0005448_abnormal_energy_balance0.57000843
162MP0001730_embryonic_growth_arrest0.56544727
163* MP0000639_abnormal_adrenal_gland0.56394138
164MP0003136_yellow_coat_color0.55779324
165MP0002092_abnormal_eye_morphology0.55639811
166MP0001286_abnormal_eye_development0.55304030
167MP0005381_digestive/alimentary_phenotyp0.54929945
168MP0002928_abnormal_bile_duct0.54885090
169* MP0002210_abnormal_sex_determination0.54384078
170MP0003861_abnormal_nervous_system0.54364143
171MP0005394_taste/olfaction_phenotype0.52418095
172MP0005499_abnormal_olfactory_system0.52418095
173MP0001905_abnormal_dopamine_level0.51544917
174MP0001727_abnormal_embryo_implantation0.49415532
175MP0005647_abnormal_sex_gland0.48038870
176MP0006035_abnormal_mitochondrial_morpho0.46269277
177MP0004197_abnormal_fetal_growth/weight/0.46224691

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)5.23191306
2Visual hallucinations (HP:0002367)5.17633290
3Nuclear cataract (HP:0100018)4.92397371
4Abnormality of cells of the erythroid lineage (HP:0012130)4.82283821
5Abnormal number of erythroid precursors (HP:0012131)4.74276421
6Myokymia (HP:0002411)4.55169497
7Supranuclear gaze palsy (HP:0000605)4.43783196
8Focal motor seizures (HP:0011153)4.25907398
9Cerebral inclusion bodies (HP:0100314)4.03988244
10Focal seizures (HP:0007359)3.93532703
11Cholecystitis (HP:0001082)3.90694284
12Abnormal gallbladder physiology (HP:0012438)3.90694284
13Macrocytic anemia (HP:0001972)3.79656205
14Hyperthyroidism (HP:0000836)3.61504007
15Diastasis recti (HP:0001540)3.56941549
16Ankle clonus (HP:0011448)3.56700816
17Neurofibrillary tangles (HP:0002185)3.53610360
18Pallor (HP:0000980)3.22284257
19Action tremor (HP:0002345)3.22263161
20Neonatal hypoglycemia (HP:0001998)3.17783812
21Overlapping toe (HP:0001845)3.10865618
22Increased IgE level (HP:0003212)3.10621147
23Dysmetric saccades (HP:0000641)3.08881766
24Reticulocytopenia (HP:0001896)3.05773146
25Hyperglycinuria (HP:0003108)2.97793060
2611 pairs of ribs (HP:0000878)2.97770093
27Impaired social interactions (HP:0000735)2.95528798
28Abnormal social behavior (HP:0012433)2.95528798
29Abnormality of the lower motor neuron (HP:0002366)2.94770722
30Abnormality of reticulocytes (HP:0004312)2.92656757
31Truncal ataxia (HP:0002078)2.89179731
32Generalized tonic-clonic seizures (HP:0002069)2.87822739
33Papilledema (HP:0001085)2.87020714
34Reticulocytosis (HP:0001923)2.86443730
35Acute necrotizing encephalopathy (HP:0006965)2.84698401
36Depression (HP:0000716)2.81478131
37Abnormal mitochondria in muscle tissue (HP:0008316)2.80586162
38Mutism (HP:0002300)2.79655753
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.78015218
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.78015218
41Poor eye contact (HP:0000817)2.77802654
42Neoplasm of the adrenal cortex (HP:0100641)2.76087411
43Acute encephalopathy (HP:0006846)2.73138168
44Resting tremor (HP:0002322)2.67260481
45Epileptic encephalopathy (HP:0200134)2.66901894
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.66311163
47Urinary urgency (HP:0000012)2.66236987
48Postural instability (HP:0002172)2.65793200
49Insomnia (HP:0100785)2.63034795
50Hypercortisolism (HP:0001578)2.61711871
51Rapidly progressive (HP:0003678)2.60234941
52Deep venous thrombosis (HP:0002625)2.59788346
53Segmental peripheral demyelination/remyelination (HP:0003481)2.57707308
54Apathy (HP:0000741)2.56541210
55Abnormal eating behavior (HP:0100738)2.54779236
56Progressive cerebellar ataxia (HP:0002073)2.49584348
57Birth length less than 3rd percentile (HP:0003561)2.49166311
58Urinary bladder sphincter dysfunction (HP:0002839)2.48772599
59Impaired vibration sensation in the lower limbs (HP:0002166)2.46603168
60Macroorchidism (HP:0000053)2.46411601
61Upper limb amyotrophy (HP:0009129)2.45379283
62Distal upper limb amyotrophy (HP:0007149)2.45379283
63Impaired smooth pursuit (HP:0007772)2.44255497
64Dysmetria (HP:0001310)2.43038849
65Absence seizures (HP:0002121)2.42666392
66Anxiety (HP:0000739)2.42549673
67Elfin facies (HP:0004428)2.42212821
68Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.41977795
69Hypercalcemia (HP:0003072)2.41843757
70Hyperglycinemia (HP:0002154)2.39774055
71Deep palmar crease (HP:0006191)2.39328036
72Ventricular fibrillation (HP:0001663)2.38423729
73Diminished motivation (HP:0000745)2.37905018
74Renal duplication (HP:0000075)2.37455756
75Enlarged penis (HP:0000040)2.37321700
76Hand muscle atrophy (HP:0009130)2.36246869
77Hemiplegia (HP:0002301)2.36163430
78Termporal pattern (HP:0011008)2.36126192
79Insidious onset (HP:0003587)2.36126192
80Dysdiadochokinesis (HP:0002075)2.34969893
81Amyotrophic lateral sclerosis (HP:0007354)2.34825410
82Facial hemangioma (HP:0000329)2.33104270
83Torticollis (HP:0000473)2.33077505
84Global brain atrophy (HP:0002283)2.32967699
85Neuronal loss in central nervous system (HP:0002529)2.31591395
86Abnormality of glycine metabolism (HP:0010895)2.30534942
87Abnormality of serine family amino acid metabolism (HP:0010894)2.30534942
88Hyperacusis (HP:0010780)2.29449709
89Mitochondrial inheritance (HP:0001427)2.28360885
90Hypercalciuria (HP:0002150)2.27621513
91Ankyloglossia (HP:0010296)2.26255283
92Spastic gait (HP:0002064)2.26119207
93Diplopia (HP:0000651)2.24253692
94Abnormality of binocular vision (HP:0011514)2.24253692
95Amblyopia (HP:0000646)2.24220777
96Menstrual irregularities (HP:0000858)2.21409419
97Bradykinesia (HP:0002067)2.20493925
98Hepatocellular necrosis (HP:0001404)2.20242082
99Lower limb amyotrophy (HP:0007210)2.20003207
100Stereotypic behavior (HP:0000733)2.16758073
101Pointed chin (HP:0000307)2.15994679
102Genetic anticipation (HP:0003743)2.15807546
103Partial duplication of thumb phalanx (HP:0009944)2.14274694
104Dialeptic seizures (HP:0011146)2.14214715
105Overriding aorta (HP:0002623)2.11309206
106Abnormality of aromatic amino acid family metabolism (HP:0004338)2.09348855
107Cerebral aneurysm (HP:0004944)2.08889162
108Focal dystonia (HP:0004373)2.07839252
109Atonic seizures (HP:0010819)2.06769704
110Intention tremor (HP:0002080)2.06447073
111Drooling (HP:0002307)2.05362187
112Excessive salivation (HP:0003781)2.05362187
113Bundle branch block (HP:0011710)2.05072220
114Agitation (HP:0000713)2.04743241
115Epiphyseal dysplasia (HP:0002656)2.03176850
116Abnormality of glycolysis (HP:0004366)2.02669574
117Septo-optic dysplasia (HP:0100842)2.00662147
118Septate vagina (HP:0001153)1.99338857
119Lower limb muscle weakness (HP:0007340)1.99085202
120Clonus (HP:0002169)1.98947747
121Achilles tendon contracture (HP:0001771)1.98847497
122Hypoventilation (HP:0002791)1.97624722
123Abnormality of ocular smooth pursuit (HP:0000617)1.97093103
124Increased CSF lactate (HP:0002490)1.96525431
125Optic neuritis (HP:0100653)1.95995584
126Retrobulbar optic neuritis (HP:0100654)1.95995584
127Vaginal fistula (HP:0004320)1.94649784
128Craniofacial dystonia (HP:0012179)1.94567762
129Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.94114083
130Fatigue (HP:0012378)1.93833840
131Abnormal pancreas size (HP:0012094)1.93795580
132Increased hepatocellular lipid droplets (HP:0006565)1.92947658
133Annular pancreas (HP:0001734)1.92075689
134Bronchomalacia (HP:0002780)1.91854491
135Delayed epiphyseal ossification (HP:0002663)1.91358778
136EEG with generalized epileptiform discharges (HP:0011198)1.91164796
137Epileptiform EEG discharges (HP:0011182)1.90893136
138Neoplasm of the adrenal gland (HP:0100631)1.90460294
139Hypsarrhythmia (HP:0002521)1.89985619
140Aqueductal stenosis (HP:0002410)1.89745772
141Germ cell neoplasia (HP:0100728)1.89733685
142Hypercholesterolemia (HP:0003124)1.89207994
143Megalencephaly (HP:0001355)1.87972348
144Progressive macrocephaly (HP:0004481)1.86122754
145Metaphyseal cupping (HP:0003021)1.85704544
146Abnormality of oral frenula (HP:0000190)1.85518207
147Flat cornea (HP:0007720)1.85365001
148Restlessness (HP:0000711)1.85224743
149Dysostosis multiplex (HP:0000943)1.85135604
150Hyperparathyroidism (HP:0000843)1.85044753
151Progressive inability to walk (HP:0002505)1.84579436
152Embryonal neoplasm (HP:0002898)1.83669885
153Psychosis (HP:0000709)1.83264614
154Abnormality of the corticospinal tract (HP:0002492)1.82582150
155Truncus arteriosus (HP:0001660)1.81771788
156Gout (HP:0001997)1.81659614
157Pheochromocytoma (HP:0002666)1.81217624
158Abnormality of the Achilles tendon (HP:0005109)1.81178822
159Lower limb asymmetry (HP:0100559)1.80213330
160Bicornuate uterus (HP:0000813)1.80132411
161Abnormal urine phosphate concentration (HP:0012599)1.80015806
162Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.79640218
163Cholelithiasis (HP:0001081)1.79500741
164Status epilepticus (HP:0002133)1.79337617
165Abnormality of the gallbladder (HP:0005264)1.77651763
166Hammertoe (HP:0001765)1.77187715
167Renovascular hypertension (HP:0100817)1.77159595
168Lipid accumulation in hepatocytes (HP:0006561)1.76924747
169Rigidity (HP:0002063)1.76883119
170Widely patent fontanelles and sutures (HP:0004492)1.76780553
171Spastic tetraparesis (HP:0001285)1.76589007
172Shallow orbits (HP:0000586)1.75333669
173Hepatic necrosis (HP:0002605)1.74740130
174Scanning speech (HP:0002168)1.74643772
175Small epiphyses (HP:0010585)1.73656907
176Enlarged kidneys (HP:0000105)1.73371864
177Dysphonia (HP:0001618)1.71996029
178Renal Fanconi syndrome (HP:0001994)1.70889698
179Metaphyseal dysplasia (HP:0100255)1.70856285
180Testicular atrophy (HP:0000029)1.69365834
181Megaloblastic anemia (HP:0001889)1.69067889
182Increased intramyocellular lipid droplets (HP:0012240)1.67452295
183Hypophosphatemia (HP:0002148)1.65802579
184Zonular cataract (HP:0010920)1.65055113
185Peripheral hypomyelination (HP:0007182)1.62608676
186Abnormality of the parathyroid morphology (HP:0011766)1.60404427
187Adrenal hypoplasia (HP:0000835)1.60243169
188Horseshoe kidney (HP:0000085)1.59977517
189Hypoparathyroidism (HP:0000829)1.59553923
190Intrahepatic cholestasis (HP:0001406)1.59172655
191Progressive external ophthalmoplegia (HP:0000590)1.59110627
192Lactic acidosis (HP:0003128)1.57447837
193Hypertensive crisis (HP:0100735)1.56195994
194Paralysis (HP:0003470)1.54921926
195Partial duplication of the phalanx of hand (HP:0009999)1.53731191

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.52078596
2NME23.90278414
3TRIB33.82836222
4IRAK33.37344520
5NTRK33.27771909
6KSR22.91337683
7NME12.77341016
8PIM22.70523027
9SMG12.57120903
10LATS22.53928497
11EPHA42.48880680
12MINK12.43547755
13MAP3K112.39548505
14MAP2K62.37566868
15MARK12.36601541
16TAOK12.33106110
17PAK62.30506225
18NTRK12.22916249
19DAPK22.14180394
20CAMKK12.13851192
21PKN22.08424730
22PRKD32.07799245
23ICK1.90421084
24DYRK1B1.89844780
25DYRK21.87518594
26EEF2K1.82719485
27IRAK41.81473225
28VRK21.76951387
29IRAK21.75041908
30CDC71.73860901
31MAP3K41.71345285
32SIK21.68535909
33STK161.68157202
34KSR11.66684236
35MAP4K11.52345109
36RET1.49199247
37ALK1.45734828
38MAP3K101.43420622
39TNIK1.42915805
40WNK41.42882832
41STK381.41607299
42MAP3K21.40008194
43DYRK31.37814871
44SCYL21.36951505
45FGFR41.35001144
46NTRK21.31730778
47CDK51.27260312
48FES1.25896166
49PRKCH1.21101157
50BRAF1.20164569
51RAF11.17937348
52RIPK41.15281839
53ARAF1.13527033
54NEK11.13305153
55CAMKK21.10771010
56PASK1.09515865
57GRK51.09296462
58TAOK21.06718745
59MAP2K41.05712707
60MAP3K121.03000302
61LRRK21.02292486
62MATK1.01775853
63PTK21.00604934
64PDPK10.98440636
65CHUK0.98409591
66CASK0.97594519
67STK110.97336564
68TAF10.95435714
69LMTK20.93485357
70DAPK10.91739614
71ERN10.88830590
72FGR0.87706658
73PDK10.87133465
74MAP2K10.85670437
75MARK20.82946821
76MAP3K130.82461267
77GRK60.81756121
78RPS6KA50.80595007
79CSNK1E0.80433089
80PDGFRA0.80378549
81TYRO30.79870368
82EPHA20.78387690
83PRKCG0.78203602
84RIPK10.77330190
85LATS10.75589719
86CAMK1G0.75047256
87HIPK20.73852663
88MAP3K10.73538937
89PAK30.73329675
90AURKA0.73237996
91PTK2B0.72769496
92PNCK0.71133815
93CDK140.70723052
94RPS6KA10.69833876
95PTK60.69791520
96RPS6KA20.69355024
97PIM10.68249861
98PLK20.67851705
99IRAK10.67530367
100STK390.67318112
101BRD40.67284911
102VRK10.67261964
103CDK180.65609288
104SGK30.64392981
105CSNK2A20.63911146
106CDK150.63867944
107PHKG20.63645684
108PHKG10.63645684
109CDK40.63606159
110CAMK10.61410202
111IKBKB0.61067864
112MAPK130.59257562
113CDK11A0.55287117
114TNK20.54462580
115TBK10.53610481
116MAP3K70.53572888
117PRKCZ0.51749419
118PLK10.51214546
119EPHB10.50425410
120PDGFRB0.50185792
121DMPK0.50119867
122AKT20.49641026
123ILK0.49079117
124MAP3K80.48672530
125CHEK20.48525786
126INSRR0.48323918
127HCK0.48206460
128PRKCI0.47242122
129CDK120.47007888
130SGK2230.45479377
131SGK4940.45479377
132PRPF4B0.44803518
133MAPK110.44396623
134DAPK30.44392751
135CAMK2A0.44301354
136WNK10.43874259
137FGFR10.43476814
138RPS6KL10.43432302
139RPS6KC10.43432302
140SIK10.43342816
141FER0.42997390
142MAPKAPK50.42277405
143BMX0.41959745
144FYN0.40742146
145CSNK2A10.40361518
146SGK10.40248907
147CDK70.40070258
148RPS6KA60.39848608
149PRKD10.39602179
150MOS0.38238461
151MTOR0.36831336
152CAMK1D0.36458873
153MAP2K70.35895642
154CSNK1G20.35789735
155NLK0.35747089
156AKT10.35655185
157JAK20.35578216
158UHMK10.35531039
159IKBKE0.35084851
160SRC0.34997682
161PRKD20.33391336
162CAMK40.33287110
163FGFR20.33143506
164ZAK0.32459235
165STK240.31625532

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.29016868
2Oxidative phosphorylation_Homo sapiens_hsa001904.53481947
3Parkinsons disease_Homo sapiens_hsa050123.67694149
4Synaptic vesicle cycle_Homo sapiens_hsa047212.82083643
5Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.77983564
6Alzheimers disease_Homo sapiens_hsa050102.38880698
7Long-term potentiation_Homo sapiens_hsa047202.33566418
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.32885894
9Huntingtons disease_Homo sapiens_hsa050162.31250707
10Nicotine addiction_Homo sapiens_hsa050332.24477497
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.24039626
12Sulfur relay system_Homo sapiens_hsa041222.10931171
13Biosynthesis of amino acids_Homo sapiens_hsa012302.08777318
14Olfactory transduction_Homo sapiens_hsa047402.07911426
15Fructose and mannose metabolism_Homo sapiens_hsa000512.02726187
16Circadian entrainment_Homo sapiens_hsa047132.00742702
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.98796055
18Salivary secretion_Homo sapiens_hsa049701.94268284
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.91663428
20GABAergic synapse_Homo sapiens_hsa047271.87452830
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.86697135
22Amphetamine addiction_Homo sapiens_hsa050311.83323122
23DNA replication_Homo sapiens_hsa030301.82751959
24Spliceosome_Homo sapiens_hsa030401.82648481
25Glutamatergic synapse_Homo sapiens_hsa047241.82601261
26Arginine and proline metabolism_Homo sapiens_hsa003301.79315960
27Morphine addiction_Homo sapiens_hsa050321.78597257
28Fatty acid biosynthesis_Homo sapiens_hsa000611.75810785
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.75608345
30Dopaminergic synapse_Homo sapiens_hsa047281.70572240
31Gastric acid secretion_Homo sapiens_hsa049711.70450066
32Glioma_Homo sapiens_hsa052141.64971930
33Galactose metabolism_Homo sapiens_hsa000521.63758061
34Steroid biosynthesis_Homo sapiens_hsa001001.63318022
35Cholinergic synapse_Homo sapiens_hsa047251.55847839
36RNA polymerase_Homo sapiens_hsa030201.53896051
37Insulin secretion_Homo sapiens_hsa049111.52976061
38Estrogen signaling pathway_Homo sapiens_hsa049151.52761485
39One carbon pool by folate_Homo sapiens_hsa006701.52374473
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50776906
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50069331
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49849616
43Renin secretion_Homo sapiens_hsa049241.48921633
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45532214
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.43750842
46Long-term depression_Homo sapiens_hsa047301.43610008
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41436360
48Oxytocin signaling pathway_Homo sapiens_hsa049211.39611581
49Cocaine addiction_Homo sapiens_hsa050301.38496052
50Pyruvate metabolism_Homo sapiens_hsa006201.35654155
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.35339273
52GnRH signaling pathway_Homo sapiens_hsa049121.34753304
53Nitrogen metabolism_Homo sapiens_hsa009101.34592604
54Type II diabetes mellitus_Homo sapiens_hsa049301.32556356
55Cardiac muscle contraction_Homo sapiens_hsa042601.31019283
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27168691
57Gap junction_Homo sapiens_hsa045401.25062899
58VEGF signaling pathway_Homo sapiens_hsa043701.20396970
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18990786
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17701635
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14686079
62Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13611379
63Neurotrophin signaling pathway_Homo sapiens_hsa047221.12179155
64mTOR signaling pathway_Homo sapiens_hsa041501.10014477
65ErbB signaling pathway_Homo sapiens_hsa040121.09292667
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.08723874
67Carbon metabolism_Homo sapiens_hsa012001.08370138
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07913752
69Taste transduction_Homo sapiens_hsa047421.07460188
70Calcium signaling pathway_Homo sapiens_hsa040201.04843394
71cAMP signaling pathway_Homo sapiens_hsa040241.04360838
72Collecting duct acid secretion_Homo sapiens_hsa049661.03856580
73Non-small cell lung cancer_Homo sapiens_hsa052231.03196388
74Pancreatic secretion_Homo sapiens_hsa049721.02472242
75Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01656267
76Proteasome_Homo sapiens_hsa030501.01654042
77Serotonergic synapse_Homo sapiens_hsa047261.01456546
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01143373
79Cysteine and methionine metabolism_Homo sapiens_hsa002701.00251957
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99757351
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99597937
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.98023546
83Renal cell carcinoma_Homo sapiens_hsa052110.97532043
84Cell cycle_Homo sapiens_hsa041100.97356342
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.95825349
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94127909
87Insulin signaling pathway_Homo sapiens_hsa049100.92798605
88Endocytosis_Homo sapiens_hsa041440.91696773
89HIF-1 signaling pathway_Homo sapiens_hsa040660.89831303
90Axon guidance_Homo sapiens_hsa043600.89820950
91Endometrial cancer_Homo sapiens_hsa052130.89713270
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.88961200
93Vibrio cholerae infection_Homo sapiens_hsa051100.88890501
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87488012
95Melanogenesis_Homo sapiens_hsa049160.87485185
96Bladder cancer_Homo sapiens_hsa052190.87407610
97Dorso-ventral axis formation_Homo sapiens_hsa043200.86623516
98Pyrimidine metabolism_Homo sapiens_hsa002400.86371580
99Basal cell carcinoma_Homo sapiens_hsa052170.85085322
100Alcoholism_Homo sapiens_hsa050340.84662709
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82255083
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82021544
103Choline metabolism in cancer_Homo sapiens_hsa052310.81671056
104Vitamin digestion and absorption_Homo sapiens_hsa049770.78608099
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77600944
106Base excision repair_Homo sapiens_hsa034100.76917588
107Oocyte meiosis_Homo sapiens_hsa041140.76727016
108Hedgehog signaling pathway_Homo sapiens_hsa043400.76104864
109Thyroid hormone synthesis_Homo sapiens_hsa049180.75094674
110Rap1 signaling pathway_Homo sapiens_hsa040150.74096290
111Epstein-Barr virus infection_Homo sapiens_hsa051690.73697826
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73332199
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.73031321
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72904854
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72288078
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.72073564
117Systemic lupus erythematosus_Homo sapiens_hsa053220.70032800
118Glucagon signaling pathway_Homo sapiens_hsa049220.69526033
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68132695
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.68015986
121Notch signaling pathway_Homo sapiens_hsa043300.67190835
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66692419
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66563061
124MAPK signaling pathway_Homo sapiens_hsa040100.65904658
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62388658
126Platelet activation_Homo sapiens_hsa046110.62002969
127Purine metabolism_Homo sapiens_hsa002300.61096552
128Chronic myeloid leukemia_Homo sapiens_hsa052200.60671013
129Pentose phosphate pathway_Homo sapiens_hsa000300.60247080
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59899333
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59779076
132Inositol phosphate metabolism_Homo sapiens_hsa005620.59131557
133Metabolic pathways_Homo sapiens_hsa011000.57850647
134Glycerolipid metabolism_Homo sapiens_hsa005610.57783013
135Prolactin signaling pathway_Homo sapiens_hsa049170.56981810
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56276926
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55135693
138Ras signaling pathway_Homo sapiens_hsa040140.54895171
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54783287
140Arginine biosynthesis_Homo sapiens_hsa002200.53219788
141Pancreatic cancer_Homo sapiens_hsa052120.52056020
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51400344
143Chemokine signaling pathway_Homo sapiens_hsa040620.51344872
144Bile secretion_Homo sapiens_hsa049760.50984918
145Starch and sucrose metabolism_Homo sapiens_hsa005000.50592917
146Insulin resistance_Homo sapiens_hsa049310.50448892
147Melanoma_Homo sapiens_hsa052180.50181711
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49971789
149Homologous recombination_Homo sapiens_hsa034400.49695148
150Proteoglycans in cancer_Homo sapiens_hsa052050.49549028
151Lysosome_Homo sapiens_hsa041420.49151035
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.48886002
153Acute myeloid leukemia_Homo sapiens_hsa052210.48234755
154Dilated cardiomyopathy_Homo sapiens_hsa054140.47663542
155AMPK signaling pathway_Homo sapiens_hsa041520.45986754
156Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45674277
157Adipocytokine signaling pathway_Homo sapiens_hsa049200.44919018
158Colorectal cancer_Homo sapiens_hsa052100.44700093
159African trypanosomiasis_Homo sapiens_hsa051430.43242885
160Focal adhesion_Homo sapiens_hsa045100.42139135
161Mismatch repair_Homo sapiens_hsa034300.40949161
162Prion diseases_Homo sapiens_hsa050200.39754972
163Folate biosynthesis_Homo sapiens_hsa007900.38572130
164Protein export_Homo sapiens_hsa030600.38150809
165Rheumatoid arthritis_Homo sapiens_hsa053230.36352307
166p53 signaling pathway_Homo sapiens_hsa041150.33311098
167Viral carcinogenesis_Homo sapiens_hsa052030.31095356
168Phenylalanine metabolism_Homo sapiens_hsa003600.30415314
169RNA degradation_Homo sapiens_hsa030180.26962517
170B cell receptor signaling pathway_Homo sapiens_hsa046620.26931420
171Thyroid cancer_Homo sapiens_hsa052160.25696780
172Fatty acid metabolism_Homo sapiens_hsa012120.25414360
173Other glycan degradation_Homo sapiens_hsa005110.24228205
174Malaria_Homo sapiens_hsa051440.21911285
175Salmonella infection_Homo sapiens_hsa051320.20707098
176Sulfur metabolism_Homo sapiens_hsa009200.19613698
177Wnt signaling pathway_Homo sapiens_hsa043100.18796156
178Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.18394702
179Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17937489
180Apoptosis_Homo sapiens_hsa042100.17902286
181mRNA surveillance pathway_Homo sapiens_hsa030150.17897803

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