KIZ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene localizes to centrosomes, strengthening and stabilizing the pericentriolar region prior to spindle formation. The encoded protein usually remains with the mother centrosome after centrosomal duplication. Sevral transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)8.93457107
2cilium or flagellum-dependent cell motility (GO:0001539)8.73328995
3sperm motility (GO:0030317)7.79517857
4sperm-egg recognition (GO:0035036)7.70246068
5positive regulation of synaptic transmission, dopaminergic (GO:0032226)7.42222861
6binding of sperm to zona pellucida (GO:0007339)7.31642365
7acrosome assembly (GO:0001675)7.29604279
8cell wall macromolecule metabolic process (GO:0044036)6.94852786
9cell wall macromolecule catabolic process (GO:0016998)6.94852786
10axonemal dynein complex assembly (GO:0070286)6.93827339
11cell-cell recognition (GO:0009988)6.82120886
12multicellular organism reproduction (GO:0032504)6.81742818
13plasma membrane fusion (GO:0045026)6.79934913
14piRNA metabolic process (GO:0034587)6.63551947
15regulation of phosphoprotein phosphatase activity (GO:0043666)6.40088117
16acrosome reaction (GO:0007340)6.39362630
17epithelial cilium movement (GO:0003351)6.35277449
18male meiosis (GO:0007140)6.17356839
19synaptonemal complex organization (GO:0070193)6.13224663
20positive regulation of catecholamine secretion (GO:0033605)6.06224600
21motile cilium assembly (GO:0044458)6.00013650
22reproduction (GO:0000003)5.86976275
23synaptonemal complex assembly (GO:0007130)5.86201458
24spermatid development (GO:0007286)5.80684026
25cilium movement (GO:0003341)5.46436040
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.40609708
27regulation of oxidative stress-induced neuron death (GO:1903203)5.34151151
28regulation of cilium movement (GO:0003352)5.16604275
29relaxation of smooth muscle (GO:0044557)5.09811546
30tricarboxylic acid cycle (GO:0006099)5.00911294
31regulation of oxidative phosphorylation (GO:0002082)4.85554396
32sperm capacitation (GO:0048240)4.84232831
33diacylglycerol metabolic process (GO:0046339)4.83509364
34coenzyme catabolic process (GO:0009109)4.79375067
35activation of protein kinase B activity (GO:0032148)4.72159004
36single fertilization (GO:0007338)4.70488690
37negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.60357944
38carnitine transmembrane transport (GO:1902603)4.59332127
39amino-acid betaine transport (GO:0015838)4.52077437
40carnitine transport (GO:0015879)4.52077437
41ADP metabolic process (GO:0046031)4.51400908
42synapsis (GO:0007129)4.51020103
43negative regulation of inclusion body assembly (GO:0090084)4.43355320
44regulation of autophagic vacuole assembly (GO:2000785)4.38317385
45organic cation transport (GO:0015695)4.28534626
46DNA methylation involved in gamete generation (GO:0043046)4.20837650
47potassium ion export (GO:0071435)4.20212399
48male meiosis I (GO:0007141)4.18259743
49fertilization (GO:0009566)4.11026341
50histone H3-K36 demethylation (GO:0070544)4.10534355
51response to muscle activity (GO:0014850)4.09191408
52carnitine shuttle (GO:0006853)4.00610925
53spermatogenesis (GO:0007283)3.95168451
54male gamete generation (GO:0048232)3.94129824
55cGMP-mediated signaling (GO:0019934)3.92243409
56meiotic nuclear division (GO:0007126)3.80533706
57chromosome organization involved in meiosis (GO:0070192)3.79222737
58genitalia morphogenesis (GO:0035112)3.77479023
59seminiferous tubule development (GO:0072520)3.77057570
60negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.74735762
61TOR signaling (GO:0031929)3.70788385
62fatty acid beta-oxidation (GO:0006635)3.69380043
63fatty acid transmembrane transport (GO:1902001)3.68157599
64regulation of dopamine secretion (GO:0014059)3.68145367
65positive regulation of glycolytic process (GO:0045821)3.67045367
66tongue development (GO:0043586)3.66855104
67regulation of vacuole organization (GO:0044088)3.64542373
68DNA double-strand break processing (GO:0000729)3.64093231
69glycogen metabolic process (GO:0005977)3.64090454
70cellular glucan metabolic process (GO:0006073)3.60760177
71glucan metabolic process (GO:0044042)3.60760177
72gamete generation (GO:0007276)3.59057538
73regulation of hydrogen peroxide-induced cell death (GO:1903205)3.58512436
74monoubiquitinated protein deubiquitination (GO:0035520)3.57602168
75histone H3-K9 demethylation (GO:0033169)3.56504933
76regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.56199319
77regulation of inclusion body assembly (GO:0090083)3.56142773
78histone exchange (GO:0043486)3.54666794
79glutamine family amino acid catabolic process (GO:0009065)3.51408152
80AMP metabolic process (GO:0046033)3.47993811
81quaternary ammonium group transport (GO:0015697)3.47858108
82meiosis I (GO:0007127)3.47683162
83glycerol ether metabolic process (GO:0006662)3.47355210
84fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.42403773
85cellular process involved in reproduction in multicellular organism (GO:0022412)3.41095160
86negative regulation of response to reactive oxygen species (GO:1901032)3.40206239
87regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.38905018
88plasma lipoprotein particle assembly (GO:0034377)3.35242016
89germ cell development (GO:0007281)3.33510796
90protein-DNA complex disassembly (GO:0032986)3.25863902
91nucleosome disassembly (GO:0006337)3.25863902
92peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.23818985
93fatty acid catabolic process (GO:0009062)3.20647837
94valine metabolic process (GO:0006573)3.19220420
95regulation of gene silencing by RNA (GO:0060966)3.19173606
96regulation of posttranscriptional gene silencing (GO:0060147)3.19173606
97regulation of gene silencing by miRNA (GO:0060964)3.19173606
98male sex determination (GO:0030238)3.19061275
99regulation of apoptotic cell clearance (GO:2000425)3.18518757
100tricarboxylic acid metabolic process (GO:0072350)3.18345852
101protein-lipid complex assembly (GO:0065005)3.17961373
102very-low-density lipoprotein particle assembly (GO:0034379)3.17358740
103negative regulation of translational initiation (GO:0045947)3.15558570
104intraciliary transport (GO:0042073)3.14755746
105negative regulation of striated muscle cell apoptotic process (GO:0010664)3.13650978
106regulation of protein activation cascade (GO:2000257)3.13415291
107axoneme assembly (GO:0035082)3.12893112
108receptor recycling (GO:0001881)3.11723940
109regulation of bile acid biosynthetic process (GO:0070857)3.11145201
110regulation of complement activation (GO:0030449)3.11056269
111regulation of non-canonical Wnt signaling pathway (GO:2000050)3.10129746
112ether metabolic process (GO:0018904)3.09801715
113mRNA cleavage (GO:0006379)3.08653979
114fatty acid oxidation (GO:0019395)3.07459143
115regulation of fatty acid oxidation (GO:0046320)3.06111341
116carnitine metabolic process (GO:0009437)3.05914880
1172-oxoglutarate metabolic process (GO:0006103)3.04195573
118gene silencing by RNA (GO:0031047)3.02789580
119androgen biosynthetic process (GO:0006702)3.02123988
120heterochromatin organization (GO:0070828)3.01231392
121aspartate family amino acid catabolic process (GO:0009068)3.01156053
122regulation of ARF GTPase activity (GO:0032312)2.99097899
123lysine catabolic process (GO:0006554)2.98841829
124lysine metabolic process (GO:0006553)2.98841829
125lipid oxidation (GO:0034440)2.98670196
126Leydig cell differentiation (GO:0033327)2.98298367
127lactate metabolic process (GO:0006089)2.96497922
128negative regulation of JNK cascade (GO:0046329)2.92973233
129microtubule severing (GO:0051013)2.92855228
130regulation of microtubule-based movement (GO:0060632)2.92060981
131vitamin transmembrane transport (GO:0035461)2.89086166
132cellular zinc ion homeostasis (GO:0006882)2.88942827
133positive regulation of fatty acid beta-oxidation (GO:0032000)2.85780629
134ethanol oxidation (GO:0006069)2.85445721
135regulation of acyl-CoA biosynthetic process (GO:0050812)2.84271548
136protein localization to cell surface (GO:0034394)2.84252973
137multicellular organismal reproductive process (GO:0048609)2.84211914
138regulation of cellular respiration (GO:0043457)2.83649494
139regulation of phospholipase A2 activity (GO:0032429)2.83120739
140low-density lipoprotein particle remodeling (GO:0034374)2.83085802
141sarcomere organization (GO:0045214)2.80571464
142neurotransmitter catabolic process (GO:0042135)2.79752677
143mitochondrion degradation (GO:0000422)2.79044951
144oogenesis (GO:0048477)2.77781285
145serine family amino acid catabolic process (GO:0009071)2.77729459
146left/right pattern formation (GO:0060972)2.77593992
147central nervous system myelination (GO:0022010)2.77278366
148axon ensheathment in central nervous system (GO:0032291)2.77278366
149negative regulation of potassium ion transmembrane transport (GO:1901380)2.77079179
150protein refolding (GO:0042026)2.76217864
151nucleoside diphosphate biosynthetic process (GO:0009133)2.75570706
152protein polymerization (GO:0051258)2.73425890
153negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.71604293
154potassium ion import (GO:0010107)2.71276766
155detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.70758210
156response to mercury ion (GO:0046689)2.70047408
157negative regulation of fibroblast apoptotic process (GO:2000270)2.69357986
158ventricular system development (GO:0021591)2.68910508
159regulation of sequestering of triglyceride (GO:0010889)2.68376854
160meiotic cell cycle (GO:0051321)2.67981748
161alpha-linolenic acid metabolic process (GO:0036109)2.67692939
162cell recognition (GO:0008037)2.67500565
163cellular hyperosmotic response (GO:0071474)2.67167486
164dicarboxylic acid catabolic process (GO:0043649)2.66296532
165paraxial mesoderm development (GO:0048339)2.66051097
166chaperone-mediated protein complex assembly (GO:0051131)2.65623478
167negative regulation of stress-activated protein kinase signaling cascade (GO:0070303)2.64885486
168cardiolipin metabolic process (GO:0032048)2.63889144
169spermatid nucleus differentiation (GO:0007289)2.60415856
170monocarboxylic acid catabolic process (GO:0072329)2.60402956
171positive regulation of fatty acid oxidation (GO:0046321)2.58219022
172sexual reproduction (GO:0019953)2.55293375
173amino-acid betaine metabolic process (GO:0006577)2.52147911
174regulation of fatty acid beta-oxidation (GO:0031998)2.51307424
175regulation of coenzyme metabolic process (GO:0051196)2.49383018
176regulation of cofactor metabolic process (GO:0051193)2.49383018
177mitotic sister chromatid cohesion (GO:0007064)2.49109253
178short-chain fatty acid metabolic process (GO:0046459)2.48919422
179cardiac myofibril assembly (GO:0055003)2.48693985

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.52548245
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.35563135
3BP1_19119308_ChIP-ChIP_Hs578T_Human7.37765795
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.76700852
5IGF1R_20145208_ChIP-Seq_DFB_Human5.91133425
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.75511781
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.74630104
8GBX2_23144817_ChIP-Seq_PC3_Human3.29961766
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.23743433
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.22915946
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.05855750
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.94642213
13AR_21572438_ChIP-Seq_LNCaP_Human2.90855139
14ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.86159139
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.84908783
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.73659482
17ESR1_20079471_ChIP-ChIP_T-47D_Human2.66697444
18VDR_22108803_ChIP-Seq_LS180_Human2.32126968
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.30456674
20FUS_26573619_Chip-Seq_HEK293_Human2.29067932
21CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.19673854
22PPARA_22158963_ChIP-Seq_LIVER_Mouse2.15159373
23RXR_22158963_ChIP-Seq_LIVER_Mouse2.07456042
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05648503
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03159477
26LXR_22158963_ChIP-Seq_LIVER_Mouse1.99537106
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94295734
28SCL_19346495_ChIP-Seq_HPC-7_Human1.85370678
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77721265
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.77721265
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75137415
32ER_23166858_ChIP-Seq_MCF-7_Human1.74208180
33EGR1_23403033_ChIP-Seq_LIVER_Mouse1.73905173
34VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.65794223
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.64124062
36FOXA2_19822575_ChIP-Seq_HepG2_Human1.61439975
37TBX20_22328084_ChIP-Seq_HEART_Mouse1.60726093
38TBX20_22080862_ChIP-Seq_HEART_Mouse1.60726093
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60480547
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58953872
41NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.58214666
42ZNF263_19887448_ChIP-Seq_K562_Human1.55784631
43P300_19829295_ChIP-Seq_ESCs_Human1.49680788
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48851300
45SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.46489743
46SOX2_22085726_ChIP-Seq_NPCs_Mouse1.45650444
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.45242747
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45125708
49DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.41891246
50KLF5_20875108_ChIP-Seq_MESCs_Mouse1.39566298
51NANOG_19829295_ChIP-Seq_ESCs_Human1.33278180
52SOX2_19829295_ChIP-Seq_ESCs_Human1.33278180
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32693334
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29107227
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28408886
56ZNF274_21170338_ChIP-Seq_K562_Hela1.28230460
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.28179626
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26310554
59ERG_20517297_ChIP-Seq_VCAP_Human1.24873300
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23263495
61GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22999569
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21604635
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21357374
64HNF4A_19822575_ChIP-Seq_HepG2_Human1.21318591
65RUNX2_22187159_ChIP-Seq_PCA_Human1.21244391
66FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20779281
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.20616138
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19754492
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19234029
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18453447
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17844225
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16413701
73MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.15743088
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15389423
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14304224
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.13782164
77FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.13330439
78NANOG_20526341_ChIP-Seq_ESCs_Human1.13030530
79GATA4_21415370_ChIP-Seq_HL-1_Mouse1.12640192
80AR_21909140_ChIP-Seq_LNCAP_Human1.11367914
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.10340894
82STAT1_17558387_ChIP-Seq_HELA_Human1.09684785
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.09569484
84SMAD4_21799915_ChIP-Seq_A2780_Human1.09247618
85WDR5_24793694_ChIP-Seq_LNCAP_Human1.08926005
86STAT3_23295773_ChIP-Seq_U87_Human1.08892943
87PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.08838744
88BCAT_22108803_ChIP-Seq_LS180_Human1.08574456
89ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06586948
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06233389
91TBX5_21415370_ChIP-Seq_HL-1_Mouse1.05949066
92FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05872750
93P53_21459846_ChIP-Seq_SAOS-2_Human1.04511972
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03783061
95EWS_26573619_Chip-Seq_HEK293_Human1.03473616
96KAP1_22055183_ChIP-Seq_ESCs_Mouse1.03278095
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03009191
98ERA_21632823_ChIP-Seq_H3396_Human1.02947893
99E2F1_17053090_ChIP-ChIP_MCF-7_Human1.02906486
100YY1_22570637_ChIP-Seq_MALME-3M_Human1.02783345
101RUNX1_26923725_Chip-Seq_HPCs_Mouse1.01659956
102CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00131482
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00075630
104GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99851847
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99301528
106GATA3_21867929_ChIP-Seq_CD8_Mouse0.99021663
107RARA_24833708_ChIP-Seq_LIVER_Mouse0.98546313
108SMAD4_21741376_ChIP-Seq_EPCs_Human0.98112685
109RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98068037
110ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98028642
111SALL1_21062744_ChIP-ChIP_HESCs_Human0.97409086
112ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95946214
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95467863
114FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95037291
115STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94562638
116CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94560873
117CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91777441
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91612445
119ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91550085
120FOXH1_21741376_ChIP-Seq_EPCs_Human0.91282647
121FLI1_27457419_Chip-Seq_LIVER_Mouse0.90933205
122PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90115382
123AR_20517297_ChIP-Seq_VCAP_Human0.90004232
124EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89897734
125GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89128087
126OCT4_20526341_ChIP-Seq_ESCs_Human0.89104108
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89025519
128MYC_19829295_ChIP-Seq_ESCs_Human0.88640334
129CDX2_22108803_ChIP-Seq_LS180_Human0.88481648
130RXR_22108803_ChIP-Seq_LS180_Human0.88467113
131FOXM1_23109430_ChIP-Seq_U2OS_Human0.88031413
132CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87291436
133TCF4_23295773_ChIP-Seq_U87_Human0.87126179
134FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87079161
135STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86595019
136LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.86368606
137SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86354605
138CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85829304
139PHF8_20622854_ChIP-Seq_HELA_Human0.85724077
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85416747
141ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.85102062
142TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85100055
143FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85052348
144NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84366081
145SOX2_21211035_ChIP-Seq_LN229_Gbm0.84053472
146RAC3_21632823_ChIP-Seq_H3396_Human0.83521396
147GATA3_26560356_Chip-Seq_TH1_Human0.83404489
148AR_25329375_ChIP-Seq_VCAP_Human0.83032479
149TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.82986545
150SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82654233
151TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.82451641
152OCT1_27270436_Chip-Seq_PROSTATE_Human0.81494510
153CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.81045306
154EOMES_21245162_ChIP-Seq_HESCs_Human0.80344897
155SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.79924581
156TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.79659651
157ESET_19884257_ChIP-Seq_ESCs_Mouse0.79650909
158TCF4_18268006_ChIP-ChIP_LS174T_Human0.79620928
159AHR_22903824_ChIP-Seq_MCF-7_Human0.79495207
160GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79230426
161FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.79116778
162RARB_24833708_ChIP-Seq_LIVER_Mouse0.78776289
163CBP_20019798_ChIP-Seq_JUKART_Human0.78292640
164IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.78292640
165HOXB7_26014856_ChIP-Seq_BT474_Human0.78117256
166VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.77846079
167KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.77530294
168PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.77505205
169P53_22127205_ChIP-Seq_FIBROBLAST_Human0.77341035
170GABP_19822575_ChIP-Seq_HepG2_Human0.77258880
171GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.75370187
172SPI1_20517297_ChIP-Seq_HL60_Human0.75345821
173ETS1_22383799_ChIP-Seq_G1ME_Mouse0.75320830
174TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.74971387
175TCF4_22108803_ChIP-Seq_LS180_Human0.74771997
176TBL1_22424771_ChIP-Seq_293T_Human0.73324338
177PRDM14_20953172_ChIP-Seq_ESCs_Human0.73088686
178CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.71522351
179MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.70059237
180GATA1_22025678_ChIP-Seq_K562_Human0.68836574
181SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.65411947

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.37009966
2MP0003315_abnormal_perineum_morphology4.42581524
3MP0002837_dystrophic_cardiac_calcinosis3.86061484
4MP0008004_abnormal_stomach_pH3.85070384
5MP0002132_abnormal_respiratory_system3.67149510
6MP0001929_abnormal_gametogenesis3.09746192
7MP0003698_abnormal_male_reproductive3.01624512
8MP0004084_abnormal_cardiac_muscle3.00571669
9MP0003646_muscle_fatigue2.96070479
10MP0003122_maternal_imprinting2.88236132
11MP0008877_abnormal_DNA_methylation2.87458167
12MP0009697_abnormal_copulation2.60952087
13MP0003136_yellow_coat_color2.59449098
14MP0005670_abnormal_white_adipose2.54815007
15MP0004036_abnormal_muscle_relaxation2.48930816
16MP0004130_abnormal_muscle_cell2.39454076
17MP0006036_abnormal_mitochondrial_physio2.23355754
18MP0004215_abnormal_myocardial_fiber2.22909563
19MP0000749_muscle_degeneration2.22018058
20MP0005365_abnormal_bile_salt2.21357993
21MP0000751_myopathy2.18841957
22MP0002139_abnormal_hepatobiliary_system2.16362038
23MP0002210_abnormal_sex_determination2.15441281
24MP0003806_abnormal_nucleotide_metabolis2.03513177
25MP0003011_delayed_dark_adaptation1.96973292
26MP0005394_taste/olfaction_phenotype1.95378081
27MP0005499_abnormal_olfactory_system1.95378081
28MP0005330_cardiomyopathy1.77528471
29MP0002638_abnormal_pupillary_reflex1.75384428
30MP0001529_abnormal_vocalization1.73656339
31MP0001145_abnormal_male_reproductive1.73514541
32MP0006054_spinal_hemorrhage1.71878729
33MP0002653_abnormal_ependyma_morphology1.67306576
34MP0001764_abnormal_homeostasis1.64940090
35MP0005666_abnormal_adipose_tissue1.64819790
36MP0002269_muscular_atrophy1.63392627
37MP0008775_abnormal_heart_ventricle1.60401806
38MP0002161_abnormal_fertility/fecundity1.60129540
39MP0005058_abnormal_lysosome_morphology1.57711406
40MP0010630_abnormal_cardiac_muscle1.56901403
41MP0004087_abnormal_muscle_fiber1.55840328
42MP0005085_abnormal_gallbladder_physiolo1.55738026
43MP0000653_abnormal_sex_gland1.55703763
44MP0008995_early_reproductive_senescence1.55490458
45MP0010368_abnormal_lymphatic_system1.52665111
46MP0003868_abnormal_feces_composition1.50964381
47MP0008875_abnormal_xenobiotic_pharmacok1.48794492
48MP0003385_abnormal_body_wall1.47543049
49MP0005084_abnormal_gallbladder_morpholo1.45755590
50MP0005389_reproductive_system_phenotype1.42573446
51MP0003890_abnormal_embryonic-extraembry1.42539287
52MP0010386_abnormal_urinary_bladder1.41412924
53MP0005083_abnormal_biliary_tract1.40479217
54MP0006138_congestive_heart_failure1.36509977
55MP0004272_abnormal_basement_membrane1.36330946
56MP0001544_abnormal_cardiovascular_syste1.33456992
57MP0005385_cardiovascular_system_phenoty1.33456992
58MP0002233_abnormal_nose_morphology1.28781147
59MP0002106_abnormal_muscle_physiology1.25625663
60MP0002234_abnormal_pharynx_morphology1.24912987
61MP0003718_maternal_effect1.22217286
62MP0002972_abnormal_cardiac_muscle1.19224451
63MP0003221_abnormal_cardiomyocyte_apopto1.18553891
64MP0004808_abnormal_hematopoietic_stem1.17583475
65MP0005360_urolithiasis1.15237147
66MP0005620_abnormal_muscle_contractility1.15154144
67MP0003121_genomic_imprinting1.14309676
68MP0004043_abnormal_pH_regulation1.13472331
69MP0005375_adipose_tissue_phenotype1.13434638
70MP0008789_abnormal_olfactory_epithelium1.12676504
71MP0004147_increased_porphyrin_level1.12264688
72MP0005319_abnormal_enzyme/_coenzyme1.11489723
73MP0004233_abnormal_muscle_weight1.10650670
74MP0001661_extended_life_span1.10193346
75MP0000750_abnormal_muscle_regeneration1.07110938
76MP0006072_abnormal_retinal_apoptosis1.06722911
77MP0003828_pulmonary_edema1.05950714
78MP0001188_hyperpigmentation1.03593697
79MP0005187_abnormal_penis_morphology1.02887784
80MP0010329_abnormal_lipoprotein_level1.02874850
81MP0004381_abnormal_hair_follicle1.02388471
82MP0003693_abnormal_embryo_hatching1.01728051
83MP0005220_abnormal_exocrine_pancreas1.01159646
84MP0004145_abnormal_muscle_electrophysio1.00584167
85MP0001765_abnormal_ion_homeostasis0.99800547
86MP0000759_abnormal_skeletal_muscle0.99459815
87MP0009643_abnormal_urine_homeostasis0.99187030
88MP0003252_abnormal_bile_duct0.99091123
89MP0005369_muscle_phenotype0.98838614
90MP0009840_abnormal_foam_cell0.98676563
91MP0000747_muscle_weakness0.98200402
92MP0009780_abnormal_chondrocyte_physiolo0.96254594
93MP0004264_abnormal_extraembryonic_tissu0.95784060
94MP0006035_abnormal_mitochondrial_morpho0.95733278
95MP0001849_ear_inflammation0.95265597
96MP0000358_abnormal_cell_content/0.94807384
97MP0001984_abnormal_olfaction0.94489672
98MP0005332_abnormal_amino_acid0.94483276
99MP0003123_paternal_imprinting0.94017853
100MP0000566_synostosis0.93165014
101MP0002118_abnormal_lipid_homeostasis0.92835637
102MP0003943_abnormal_hepatobiliary_system0.91611020
103MP0005636_abnormal_mineral_homeostasis0.90690370
104MP0002160_abnormal_reproductive_system0.90386691
105MP0008007_abnormal_cellular_replicative0.89719007
106MP0008058_abnormal_DNA_repair0.88710087
107MP0002909_abnormal_adrenal_gland0.87738560
108MP0005253_abnormal_eye_physiology0.87630412
109MP0002877_abnormal_melanocyte_morpholog0.87456183
110MP0004957_abnormal_blastocyst_morpholog0.87066108
111MP0003656_abnormal_erythrocyte_physiolo0.86755401
112MP0002078_abnormal_glucose_homeostasis0.86458050
113MP0001879_abnormal_lymphatic_vessel0.86379135
114MP0002108_abnormal_muscle_morphology0.86094953
115MP0003137_abnormal_impulse_conducting0.85950759
116MP0001666_abnormal_nutrient_absorption0.85097189
117MP0000920_abnormal_myelination0.85068702
118MP0002971_abnormal_brown_adipose0.84292019
119MP0000013_abnormal_adipose_tissue0.83778662
120MP0000609_abnormal_liver_physiology0.82635360
121MP0000003_abnormal_adipose_tissue0.82200530
122MP0001664_abnormal_digestion0.82110648
123MP0001944_abnormal_pancreas_morphology0.81995146
124MP0001545_abnormal_hematopoietic_system0.81605674
125MP0005397_hematopoietic_system_phenotyp0.81605674
126MP0003279_aneurysm0.81276284
127MP0003786_premature_aging0.81055460
128MP0002127_abnormal_cardiovascular_syste0.80604011
129MP0008057_abnormal_DNA_replication0.79385000
130MP0001905_abnormal_dopamine_level0.79015438
131MP0003195_calcinosis0.78371526
132MP0003567_abnormal_fetal_cardiomyocyte0.77850673
133MP0003077_abnormal_cell_cycle0.77335853
134MP0005266_abnormal_metabolism0.77301493
135MP0005551_abnormal_eye_electrophysiolog0.76826511
136MP0000266_abnormal_heart_morphology0.75161920
137MP0001270_distended_abdomen0.75065546
138MP0003941_abnormal_skin_development0.74338931
139MP0000598_abnormal_liver_morphology0.73737764
140MP0005647_abnormal_sex_gland0.72536459
141MP0001299_abnormal_eye_distance/0.71701373
142MP0010094_abnormal_chromosome_stability0.70100919
143MP0004484_altered_response_of0.70095145
144MP0005391_vision/eye_phenotype0.68864353
145MP0001293_anophthalmia0.68248556
146MP0009046_muscle_twitch0.66764526
147MP0003186_abnormal_redox_activity0.66399067
148MP0001485_abnormal_pinna_reflex0.66349955
149MP0005376_homeostasis/metabolism_phenot0.66234048
150MP0002128_abnormal_blood_circulation0.65427308
151MP0000343_altered_response_to0.65147218
152MP0005584_abnormal_enzyme/coenzyme_acti0.64847944
153MP0002249_abnormal_larynx_morphology0.63820295
154MP0001915_intracranial_hemorrhage0.62085925
155MP0003119_abnormal_digestive_system0.61190066
156MP0003632_abnormal_nervous_system0.60272138
157MP0003699_abnormal_female_reproductive0.59508281
158MP0001730_embryonic_growth_arrest0.59157043
159MP0000538_abnormal_urinary_bladder0.59057834

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.65859971
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.67168913
3Absent/shortened dynein arms (HP:0200106)7.67168913
4Chronic bronchitis (HP:0004469)6.18980592
5Abnormal respiratory motile cilium physiology (HP:0012261)6.03799994
6Abnormal respiratory epithelium morphology (HP:0012253)5.58089981
7Abnormal respiratory motile cilium morphology (HP:0005938)5.58089981
8Reduced antithrombin III activity (HP:0001976)5.22111613
9Rhinitis (HP:0012384)5.11245893
10Resting tremor (HP:0002322)5.09269582
11Nasal polyposis (HP:0100582)4.87204391
12Abnormal ciliary motility (HP:0012262)4.79130149
13Abnormality of the columella (HP:0009929)4.76919872
14Prolonged partial thromboplastin time (HP:0003645)4.57213144
15Abnormality of the nasal mucosa (HP:0000433)4.48371369
16Deep venous thrombosis (HP:0002625)4.42206383
17Myoglobinuria (HP:0002913)4.37312283
18Infertility (HP:0000789)4.05126572
19Gonadal dysgenesis (HP:0000133)3.97403384
20Sex reversal (HP:0012245)3.90715946
21Abnormal sex determination (HP:0012244)3.90715946
22Rhabdomyolysis (HP:0003201)3.69893046
23Sensory axonal neuropathy (HP:0003390)3.69150108
24Pancreatic islet-cell hyperplasia (HP:0004510)3.68193909
25Abnormality of the intrinsic pathway (HP:0010989)3.64444893
26Bronchitis (HP:0012387)3.63881565
27Hepatoblastoma (HP:0002884)3.47431631
28Ketoacidosis (HP:0001993)3.47077633
29Exercise-induced myalgia (HP:0003738)3.40089403
30Ventricular fibrillation (HP:0001663)3.36322614
31Rimmed vacuoles (HP:0003805)3.36194881
32Hypoglycemic coma (HP:0001325)3.30653789
33Small epiphyses (HP:0010585)3.30158406
34Bronchiectasis (HP:0002110)3.22315872
35Ketosis (HP:0001946)3.20702433
36Atonic seizures (HP:0010819)3.19894557
37Abnormality of the lumbar spine (HP:0100712)3.12749926
38Tubulointerstitial nephritis (HP:0001970)3.12730363
39Asymmetric septal hypertrophy (HP:0001670)3.10557958
40Postural instability (HP:0002172)3.10245916
41Exercise-induced muscle cramps (HP:0003710)3.02849430
42Facial hemangioma (HP:0000329)2.99773249
43Acanthocytosis (HP:0001927)2.99704301
44Enlarged kidneys (HP:0000105)2.93767943
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.91282343
46Dicarboxylic aciduria (HP:0003215)2.91282343
47Urinary urgency (HP:0000012)2.89534344
48Abnormality of fatty-acid metabolism (HP:0004359)2.84510077
49Palpitations (HP:0001962)2.84098678
50Capillary hemangiomas (HP:0005306)2.83483287
51Abnormality of the pancreatic islet cells (HP:0006476)2.83024099
52Abnormality of endocrine pancreas physiology (HP:0012093)2.83024099
53Gonadotropin excess (HP:0000837)2.82630880
54Nephronophthisis (HP:0000090)2.82319658
55Joint hemorrhage (HP:0005261)2.82278197
56Ventricular tachycardia (HP:0004756)2.80299660
57Supernumerary spleens (HP:0009799)2.80083229
58Abnormality of cochlea (HP:0000375)2.67932056
59Thoracic kyphosis (HP:0002942)2.67536269
60Generalized aminoaciduria (HP:0002909)2.67422950
61Colitis (HP:0002583)2.64149113
62Bile duct proliferation (HP:0001408)2.64134536
63Abnormal biliary tract physiology (HP:0012439)2.64134536
64Spontaneous abortion (HP:0005268)2.54162222
65Male pseudohermaphroditism (HP:0000037)2.52768165
66Hypobetalipoproteinemia (HP:0003563)2.52162653
67Sudden death (HP:0001699)2.51739127
68Self-mutilation (HP:0000742)2.51100796
69Bundle branch block (HP:0011710)2.50545705
70Embryonal renal neoplasm (HP:0011794)2.47143718
71Hypothermia (HP:0002045)2.46914200
72Nephroblastoma (Wilms tumor) (HP:0002667)2.45834235
73Abnormal hair whorl (HP:0010721)2.45138132
74Decreased lacrimation (HP:0000633)2.43945309
75Hyporeflexia of lower limbs (HP:0002600)2.41561831
76Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.40198831
77Hyperammonemia (HP:0001987)2.40109639
78Hyperinsulinemic hypoglycemia (HP:0000825)2.39867575
79Lipoatrophy (HP:0100578)2.39607133
80Male infertility (HP:0003251)2.37090912
81Aortic aneurysm (HP:0004942)2.36625874
82Abnormality of the ileum (HP:0001549)2.36421439
83Broad alveolar ridges (HP:0000187)2.36381554
84Calf muscle hypertrophy (HP:0008981)2.35578372
85Complement deficiency (HP:0004431)2.35172308
86Dilated cardiomyopathy (HP:0001644)2.33884694
87Abnormality of the renal cortex (HP:0011035)2.33846309
88Tubulointerstitial abnormality (HP:0001969)2.33217640
89Atrial fibrillation (HP:0005110)2.32756302
90Gout (HP:0001997)2.29179373
91Eosinophilia (HP:0001880)2.28254300
92Cerebral hypomyelination (HP:0006808)2.26520270
93Alacrima (HP:0000522)2.25250815
94Muscle fiber splitting (HP:0003555)2.24822157
95Clumsiness (HP:0002312)2.24115248
96Abnormal spermatogenesis (HP:0008669)2.23703271
97Meckel diverticulum (HP:0002245)2.22295084
98Type 2 muscle fiber atrophy (HP:0003554)2.21759678
99Hypoplasia of the uterus (HP:0000013)2.18224109
100Abnormality of the renal medulla (HP:0100957)2.17135105
101Weak cry (HP:0001612)2.16177939
102Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.15118806
103Decreased activity of mitochondrial respiratory chain (HP:0008972)2.15118806
104Abnormality of the shoulder girdle musculature (HP:0001435)2.14343024
105Primary atrial arrhythmia (HP:0001692)2.10087889
106Unsteady gait (HP:0002317)2.09238357
107Proximal tubulopathy (HP:0000114)2.07117532
108Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.07063630
109Late onset (HP:0003584)2.06728683
110Abnormality of carpal bone ossification (HP:0006257)2.06567446
111Abnormal tarsal ossification (HP:0008369)2.06355134
112Azoospermia (HP:0000027)2.05263463
113Recurrent sinusitis (HP:0011108)2.04954252
114Abnormal protein N-linked glycosylation (HP:0012347)2.03709177
115Abnormal protein glycosylation (HP:0012346)2.03709177
116Abnormal glycosylation (HP:0012345)2.03709177
117Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03709177
118Abnormality of midbrain morphology (HP:0002418)2.02955078
119Molar tooth sign on MRI (HP:0002419)2.02955078
120Supraventricular tachycardia (HP:0004755)2.02470463
121Hyperuricemia (HP:0002149)1.99741548
122Increased purine levels (HP:0004368)1.99741548
123Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.98628322
124Easy fatigability (HP:0003388)1.98330427
125Carpal bone hypoplasia (HP:0001498)1.97985940
126Muscle hypertrophy of the lower extremities (HP:0008968)1.97837203
127Abnormality of the pubic bones (HP:0003172)1.97587286
128Premature ovarian failure (HP:0008209)1.97498499
129Supraventricular arrhythmia (HP:0005115)1.97355665
130Hypoalphalipoproteinemia (HP:0003233)1.96944089
131Proximal amyotrophy (HP:0007126)1.95544185
132Median cleft lip (HP:0000161)1.94746058
133Recurrent bronchitis (HP:0002837)1.93815547
134Insulin-resistant diabetes mellitus (HP:0000831)1.93203362
135Epiphyseal dysplasia (HP:0002656)1.93188848
136Morphological abnormality of the inner ear (HP:0011390)1.92931656
137Abnormality of the alveolar ridges (HP:0006477)1.91704650
138Abnormality of the wing of the ilium (HP:0011867)1.90799112
139Methylmalonic aciduria (HP:0012120)1.90359923
140Granulocytopenia (HP:0001913)1.89776566
141Large for gestational age (HP:0001520)1.88462769
142Tubulointerstitial fibrosis (HP:0005576)1.88128105
143Diaphragmatic weakness (HP:0009113)1.87966491
144Subaortic stenosis (HP:0001682)1.87288641
145Abnormality of the left ventricular outflow tract (HP:0011103)1.87288641
146Abnormality of the thoracic spine (HP:0100711)1.87185896
147Abnormality of the common coagulation pathway (HP:0010990)1.86727382
148Recurrent otitis media (HP:0000403)1.84919177
149Centrally nucleated skeletal muscle fibers (HP:0003687)1.84692829
150Difficulty running (HP:0009046)1.83586854
151Inflammation of the large intestine (HP:0002037)1.82924686
152Abnormality of aromatic amino acid family metabolism (HP:0004338)1.82324133
153Abnormality of renal excretion (HP:0011036)1.81446279
154Abnormal hand bone ossification (HP:0010660)1.80337687
155Heart block (HP:0012722)1.79982651
156Vaginal fistula (HP:0004320)1.79462266
157Decreased muscle mass (HP:0003199)1.78483922
158Hyperglycinemia (HP:0002154)1.76815401
159Hyperkalemia (HP:0002153)1.76429973
160Difficulty climbing stairs (HP:0003551)1.75930727
161Hypoglycemic seizures (HP:0002173)1.75644399
162Hepatic necrosis (HP:0002605)1.74280210
163Renal cortical cysts (HP:0000803)1.73422726
164Polydipsia (HP:0001959)1.73227423
165Abnormal drinking behavior (HP:0030082)1.73227423
166Increased connective tissue (HP:0009025)1.72157471
167Right ventricular cardiomyopathy (HP:0011663)1.70904886
168Hyperglycemia (HP:0003074)1.70787200
169Metabolic acidosis (HP:0001942)1.70200049
170Congenital hepatic fibrosis (HP:0002612)1.70157048
171Abnormality of serine family amino acid metabolism (HP:0010894)1.69995478
172Abnormality of glycine metabolism (HP:0010895)1.69995478
173Atrioventricular block (HP:0001678)1.69689217
174Hyperglycinuria (HP:0003108)1.66894254
175Tubular atrophy (HP:0000092)1.66136402
176Abnormality of alanine metabolism (HP:0010916)1.63903029
177Hyperalaninemia (HP:0003348)1.63903029
178Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.63903029
179Insulin resistance (HP:0000855)1.63441341
180Abnormal atrioventricular conduction (HP:0005150)1.62487308
181Abnormal urine output (HP:0012590)1.61755325
182Abnormality of purine metabolism (HP:0004352)1.60897245
183Cystic liver disease (HP:0006706)1.60663763

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.72186643
2PDK47.72186643
3MARK35.06016540
4PDK24.62283259
5BCKDK2.42999152
6PRKD32.24660301
7TRIB32.22963581
8TESK12.07615747
9WNK42.06549297
10LMTK22.05080439
11MAPK152.02605124
12TTN1.99023031
13FGFR21.87824473
14SGK4941.76026798
15SGK2231.76026798
16RPS6KA51.63102659
17TIE11.59828837
18FGFR31.56388741
19CCNB11.53802433
20DYRK31.50862046
21NEK21.46958924
22NME11.40524825
23CDK31.36665801
24WEE11.35198709
25MAP2K71.32634392
26BRSK21.31530220
27PINK11.30927481
28BMPR1B1.26917043
29EIF2AK31.26854530
30ARAF1.26737441
31ACVR1B1.22372970
32EEF2K1.21807467
33FLT31.21747325
34PBK1.19930000
35PRKCQ1.19620923
36CSNK1A1L1.19566502
37EPHA31.19540803
38PTK2B1.18827145
39PKN21.17997454
40MELK1.17815681
41TGFBR11.16936150
42INSRR1.14074311
43MUSK1.11643685
44ICK1.11558013
45PASK1.10124344
46DYRK1B1.07567096
47MAP3K91.02525210
48MYLK1.01611125
49RPS6KB10.99142285
50PHKG10.95580322
51PHKG20.95580322
52OBSCN0.94948465
53CSNK1G10.94495643
54MAP4K20.94189337
55CDK120.86633359
56TGFBR20.82549762
57MAP3K10.81061842
58CSNK1G30.79162218
59RET0.79074996
60ILK0.79017208
61TLK10.78222296
62LATS20.77300032
63NEK10.76679062
64FGR0.74840589
65RIPK10.73156686
66STK390.73139915
67MAPKAPK30.71566433
68NEK90.71339720
69MAP3K100.70209599
70NLK0.70016113
71SIK10.68953508
72WNK30.67825491
73CSNK1G20.67538015
74IRAK10.64636777
75PIK3CG0.64586727
76CDC70.64276876
77STK38L0.59632668
78IRAK20.59298329
79FGFR40.58464930
80MAP3K30.58315577
81PDK10.58038418
82TNIK0.57484861
83RAF10.57205164
84AKT30.55920941
85CDC42BPA0.55879179
86PRKG10.52600226
87ZAP700.52223554
88TRPM70.52181147
89MAP3K50.52132416
90PRKAA10.52070621
91MAP2K30.50078625
92BRSK10.49685930
93SGK10.49516614
94FGFR10.48304043
95ATR0.48163110
96PAK40.47920814
97TTK0.47394204
98ZAK0.47149371
99PIK3CA0.46566185
100MAP2K60.46034272
101MTOR0.45919168
102WNK10.45648548
103MAP3K40.44913477
104MAPK110.43637165
105STK30.42670067
106PLK10.42032550
107NME20.40669323
108MAP3K130.40464504
109PKN10.40212291
110KSR20.40195227
111MAP4K10.40057529
112VRK10.39004529
113PLK30.38443127
114STK380.38116487
115PAK10.38035482
116RPS6KA40.37211869
117TEC0.36871162
118BRAF0.36609144
119LATS10.36403739
120CDK140.35608141
121BTK0.35041911
122PTK60.34560535
123CAMK10.34541073
124PRKAA20.33509154
125CAMKK20.32869264
126RPS6KA30.32861647
127EPHA40.32849960
128EGFR0.32610680
129GRK60.32189618
130NUAK10.31634412
131LRRK20.31382130
132PRKD10.31364151
133DMPK0.30714324
134CDK50.30111402
135MAP3K70.29966929
136STK240.29635000
137ERN10.29481157
138PRKG20.28175714
139FES0.27453532
140BUB10.26508298
141EPHB10.26478509
142CDK60.26037683
143CSNK2A20.26000248
144TBK10.25170441
145PDGFRA0.24879715
146SGK20.23985731
147MAP2K20.22484242
148CDK40.22210765
149RPS6KA10.21907043
150KDR0.21906473
151FRK0.21546575
152HIPK20.21541891
153TYK20.21429694
154CAMK1D0.20525283
155SGK30.20315644
156MAPKAPK50.20203005
157STK40.19528755
158PLK40.19350039
159AURKB0.18632273
160PAK30.18215588
161ATM0.17499542
162RPS6KB20.17103114
163PDPK10.16287751

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006404.59538202
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.53362425
3Fatty acid degradation_Homo sapiens_hsa000713.64992300
4Pyruvate metabolism_Homo sapiens_hsa006203.52434196
5Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.91292016
6Fatty acid metabolism_Homo sapiens_hsa012122.75170211
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.62690863
8Carbon metabolism_Homo sapiens_hsa012002.55553024
9Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.55310133
10Olfactory transduction_Homo sapiens_hsa047402.53040754
11Gap junction_Homo sapiens_hsa045402.52321803
12Selenocompound metabolism_Homo sapiens_hsa004502.50432921
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.39766844
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.14781048
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.11099546
16PPAR signaling pathway_Homo sapiens_hsa033202.04281087
17Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.86794413
18Systemic lupus erythematosus_Homo sapiens_hsa053221.86403240
19Glucagon signaling pathway_Homo sapiens_hsa049221.78893906
20Pentose phosphate pathway_Homo sapiens_hsa000301.63206534
21Regulation of autophagy_Homo sapiens_hsa041401.60882761
22Biosynthesis of amino acids_Homo sapiens_hsa012301.54186071
23Vitamin B6 metabolism_Homo sapiens_hsa007501.52173085
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.50787798
25Hedgehog signaling pathway_Homo sapiens_hsa043401.47214138
26Vitamin digestion and absorption_Homo sapiens_hsa049771.45913192
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.41792960
28Peroxisome_Homo sapiens_hsa041461.39369165
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.36018023
30Butanoate metabolism_Homo sapiens_hsa006501.34604627
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.34316065
32Sulfur metabolism_Homo sapiens_hsa009201.33849522
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.32602391
34Fatty acid elongation_Homo sapiens_hsa000621.29561648
35Tryptophan metabolism_Homo sapiens_hsa003801.29308734
36Alcoholism_Homo sapiens_hsa050341.25050378
37Caffeine metabolism_Homo sapiens_hsa002321.18944232
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16892647
39Phenylalanine metabolism_Homo sapiens_hsa003601.16633996
40Cardiac muscle contraction_Homo sapiens_hsa042601.16262448
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15237558
42Glycerolipid metabolism_Homo sapiens_hsa005611.15062337
43Fanconi anemia pathway_Homo sapiens_hsa034601.11721992
44Fatty acid biosynthesis_Homo sapiens_hsa000611.11602490
45Renin secretion_Homo sapiens_hsa049241.08951942
46Huntingtons disease_Homo sapiens_hsa050161.08330619
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.07945020
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05444664
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02183357
50Vascular smooth muscle contraction_Homo sapiens_hsa042701.01107596
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99831145
52Wnt signaling pathway_Homo sapiens_hsa043100.98902363
53Histidine metabolism_Homo sapiens_hsa003400.98762754
54Starch and sucrose metabolism_Homo sapiens_hsa005000.97917940
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96907455
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96206491
57Fat digestion and absorption_Homo sapiens_hsa049750.95785882
58Fructose and mannose metabolism_Homo sapiens_hsa000510.94713824
59DNA replication_Homo sapiens_hsa030300.93217347
60Lysine degradation_Homo sapiens_hsa003100.93188367
61Basal transcription factors_Homo sapiens_hsa030220.91824129
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91424257
63AMPK signaling pathway_Homo sapiens_hsa041520.91191438
64Sulfur relay system_Homo sapiens_hsa041220.91081653
65Oxytocin signaling pathway_Homo sapiens_hsa049210.90991618
66ABC transporters_Homo sapiens_hsa020100.90859190
67beta-Alanine metabolism_Homo sapiens_hsa004100.90131376
68Apoptosis_Homo sapiens_hsa042100.88937379
69Inositol phosphate metabolism_Homo sapiens_hsa005620.87535877
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.87237065
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85975590
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.85723359
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84932322
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84809004
75Chemical carcinogenesis_Homo sapiens_hsa052040.83659134
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82427859
77Insulin resistance_Homo sapiens_hsa049310.82109779
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80756063
79Glutathione metabolism_Homo sapiens_hsa004800.79987593
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77521066
81Dorso-ventral axis formation_Homo sapiens_hsa043200.75808908
82Purine metabolism_Homo sapiens_hsa002300.73740163
83One carbon pool by folate_Homo sapiens_hsa006700.72898211
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72779126
85Parkinsons disease_Homo sapiens_hsa050120.71658846
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69740569
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69159912
88Long-term potentiation_Homo sapiens_hsa047200.65872160
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64402946
90Folate biosynthesis_Homo sapiens_hsa007900.64099682
91RNA degradation_Homo sapiens_hsa030180.63472802
92Galactose metabolism_Homo sapiens_hsa000520.62926866
93Protein export_Homo sapiens_hsa030600.60814227
94Endometrial cancer_Homo sapiens_hsa052130.60099592
95Phagosome_Homo sapiens_hsa041450.59257072
96Metabolic pathways_Homo sapiens_hsa011000.58679438
97Steroid biosynthesis_Homo sapiens_hsa001000.58345306
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58149030
99Tyrosine metabolism_Homo sapiens_hsa003500.56736877
100Linoleic acid metabolism_Homo sapiens_hsa005910.56535989
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.55301228
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.54947435
103Calcium signaling pathway_Homo sapiens_hsa040200.53693844
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53571501
105Mismatch repair_Homo sapiens_hsa034300.53514543
106Pyrimidine metabolism_Homo sapiens_hsa002400.53433200
107Dilated cardiomyopathy_Homo sapiens_hsa054140.53359924
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53331127
109Base excision repair_Homo sapiens_hsa034100.51483664
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51454403
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51130386
112Nitrogen metabolism_Homo sapiens_hsa009100.51080388
113TGF-beta signaling pathway_Homo sapiens_hsa043500.49514911
114FoxO signaling pathway_Homo sapiens_hsa040680.46164895
115Insulin signaling pathway_Homo sapiens_hsa049100.44523752
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43503968
117RNA transport_Homo sapiens_hsa030130.43408147
118Taste transduction_Homo sapiens_hsa047420.43192393
119mTOR signaling pathway_Homo sapiens_hsa041500.42987469
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.42166233
121Retinol metabolism_Homo sapiens_hsa008300.42009148
122Gastric acid secretion_Homo sapiens_hsa049710.41830172
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41574931
124Bile secretion_Homo sapiens_hsa049760.40670896
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39539589
126Choline metabolism in cancer_Homo sapiens_hsa052310.39376089
127N-Glycan biosynthesis_Homo sapiens_hsa005100.39341539
128Cell cycle_Homo sapiens_hsa041100.38496706
129Arginine biosynthesis_Homo sapiens_hsa002200.35702002
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35627052
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32971638
132Alzheimers disease_Homo sapiens_hsa050100.30075813
133Non-homologous end-joining_Homo sapiens_hsa034500.29473248
134Nucleotide excision repair_Homo sapiens_hsa034200.29405999
135Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29361245
136Circadian rhythm_Homo sapiens_hsa047100.28809510
137mRNA surveillance pathway_Homo sapiens_hsa030150.28774363
138Complement and coagulation cascades_Homo sapiens_hsa046100.27479923
139Arginine and proline metabolism_Homo sapiens_hsa003300.27281034
140Homologous recombination_Homo sapiens_hsa034400.27129284
141Antigen processing and presentation_Homo sapiens_hsa046120.26820875
142Oocyte meiosis_Homo sapiens_hsa041140.26639069
143cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26451152

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