KL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)9.92691223
2drug transmembrane transport (GO:0006855)9.10253131
3urate metabolic process (GO:0046415)8.94769230
4drug transport (GO:0015893)7.61886374
5organic cation transport (GO:0015695)7.51686858
6phosphate ion transport (GO:0006817)6.83181648
7lysine metabolic process (GO:0006553)5.92725716
8lysine catabolic process (GO:0006554)5.92725716
9exogenous drug catabolic process (GO:0042738)5.87814950
10drug catabolic process (GO:0042737)5.74792699
11sodium-independent organic anion transport (GO:0043252)5.68922312
12quaternary ammonium group transport (GO:0015697)5.63479288
13excretion (GO:0007588)5.40392598
14response to mercury ion (GO:0046689)5.39482123
15phosphate ion transmembrane transport (GO:0035435)5.32332467
16glyoxylate metabolic process (GO:0046487)5.20350706
17toxin transport (GO:1901998)5.08677093
18vitamin D metabolic process (GO:0042359)4.95803117
19nonribosomal peptide biosynthetic process (GO:0019184)4.88941951
20oligosaccharide catabolic process (GO:0009313)4.85996057
21metanephric tubule development (GO:0072170)4.81285009
22metanephric nephron tubule development (GO:0072234)4.81285009
23renal absorption (GO:0070293)4.80488977
24trivalent inorganic anion homeostasis (GO:0072506)4.73198942
25phosphate ion homeostasis (GO:0055062)4.73198942
26metanephric nephron epithelium development (GO:0072243)4.52026673
27short-chain fatty acid metabolic process (GO:0046459)4.45560152
28branched-chain amino acid metabolic process (GO:0009081)4.44947435
29modified amino acid transport (GO:0072337)4.44690924
30glycoside metabolic process (GO:0016137)4.43932136
31tricarboxylic acid metabolic process (GO:0072350)4.42691444
32cysteine metabolic process (GO:0006534)4.31968535
33glutathione biosynthetic process (GO:0006750)4.30990006
34metanephric epithelium development (GO:0072207)4.19508002
35membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.17314358
36aspartate family amino acid catabolic process (GO:0009068)4.17103371
37membrane repolarization during action potential (GO:0086011)4.10696080
38actin filament depolymerization (GO:0030042)3.94863293
39erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.93638325
40L-phenylalanine catabolic process (GO:0006559)3.93638325
41nephron tubule development (GO:0072080)3.85822260
42nephron epithelium morphogenesis (GO:0072088)3.81226090
43nephron tubule morphogenesis (GO:0072078)3.81226090
44polyol transport (GO:0015791)3.80820892
45tryptophan metabolic process (GO:0006568)3.80357664
46auditory receptor cell differentiation (GO:0042491)3.79519162
47aromatic amino acid family catabolic process (GO:0009074)3.79022674
48L-phenylalanine metabolic process (GO:0006558)3.74734228
49erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.74734228
50peptide biosynthetic process (GO:0043043)3.74475208
51branched-chain amino acid catabolic process (GO:0009083)3.71519323
52carnitine transport (GO:0015879)3.70920580
53amino-acid betaine transport (GO:0015838)3.70920580
54peptide catabolic process (GO:0043171)3.68798152
55indole-containing compound catabolic process (GO:0042436)3.66207675
56indolalkylamine catabolic process (GO:0046218)3.66207675
57tryptophan catabolic process (GO:0006569)3.66207675
58bicarbonate transport (GO:0015701)3.63552768
59valine metabolic process (GO:0006573)3.62796628
60vitamin transport (GO:0051180)3.61681360
61cellular modified amino acid catabolic process (GO:0042219)3.53860543
62homocysteine metabolic process (GO:0050667)3.51515124
63indole-containing compound metabolic process (GO:0042430)3.51468341
64fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.49909079
65proline metabolic process (GO:0006560)3.47613905
66sodium ion transport (GO:0006814)3.47112116
67righting reflex (GO:0060013)3.46481459
68renal tubule development (GO:0061326)3.45877776
69sulfur compound transport (GO:0072348)3.41025463
70response to parathyroid hormone (GO:0071107)3.39074389
71collecting duct development (GO:0072044)3.38188621
72vasodilation (GO:0042311)3.33989749
73cardiovascular system development (GO:0072358)3.31910310
74positive regulation of gluconeogenesis (GO:0045722)3.27567890
75positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.27239490
76positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.26508813
77regulation of type B pancreatic cell apoptotic process (GO:2000674)3.25389142
78nephron epithelium development (GO:0072009)3.22781958
79fatty acid beta-oxidation (GO:0006635)3.22370037
80fructose metabolic process (GO:0006000)3.19491924
81endothelium development (GO:0003158)3.19302891
82cell volume homeostasis (GO:0006884)3.19293581
83serine family amino acid catabolic process (GO:0009071)3.14550353
84negative regulation of complement activation (GO:0045916)3.14057673
85detection of calcium ion (GO:0005513)3.13029716
86sphingomyelin metabolic process (GO:0006684)3.12854303
87peptide hormone processing (GO:0016486)3.08392254
88renal tubule morphogenesis (GO:0061333)3.06813282
89response to magnesium ion (GO:0032026)3.06122514
90glutathione metabolic process (GO:0006749)3.05248582
91cellular response to vitamin D (GO:0071305)3.04747772
92amino-acid betaine metabolic process (GO:0006577)3.04499703
93potassium ion import (GO:0010107)3.01742504
94fatty acid oxidation (GO:0019395)3.01694284
95brain morphogenesis (GO:0048854)3.00400338
96glycerophospholipid catabolic process (GO:0046475)2.98245628
97heparin biosynthetic process (GO:0030210)2.97694274
98heparin metabolic process (GO:0030202)2.97694274
99lipid oxidation (GO:0034440)2.97062996
100inositol metabolic process (GO:0006020)2.96151914
101indolalkylamine metabolic process (GO:0006586)2.95963376
102basic amino acid transport (GO:0015802)2.94358852
103neurotransmitter biosynthetic process (GO:0042136)2.92379938
104response to phenylpropanoid (GO:0080184)2.92153191
105biotin metabolic process (GO:0006768)2.91882790
106cobalamin metabolic process (GO:0009235)2.91795929
107dicarboxylic acid biosynthetic process (GO:0043650)2.89904015
108polyol catabolic process (GO:0046174)2.88020734
109regulation of calcium ion import (GO:0090279)2.87272236
110aromatic amino acid family metabolic process (GO:0009072)2.87015891
111response to lipoprotein particle (GO:0055094)2.86647740
112cellular ketone body metabolic process (GO:0046950)2.85674261
113serine family amino acid metabolic process (GO:0009069)2.85091841
114membrane repolarization (GO:0086009)2.84997780
115vitamin transmembrane transport (GO:0035461)2.84983479
116mitochondrion distribution (GO:0048311)2.84905626
117sulfate transport (GO:0008272)2.84356371
118carnitine metabolic process (GO:0009437)2.84045928
119response to lead ion (GO:0010288)2.83564774
120transepithelial transport (GO:0070633)2.81453430
121positive regulation of calcium ion import (GO:0090280)2.80352943
122cellular amino acid catabolic process (GO:0009063)2.78925917
123inorganic anion transport (GO:0015698)2.77576223
124positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.76880183
125response to thyroid hormone (GO:0097066)2.75560053
126positive regulation of glycogen biosynthetic process (GO:0045725)2.75297620
127negative regulation of execution phase of apoptosis (GO:1900118)2.75170320
128regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.74711421
1292-oxoglutarate metabolic process (GO:0006103)2.73072115
130artery smooth muscle contraction (GO:0014824)2.72605724
131negative regulation of protein activation cascade (GO:2000258)2.71048517
132negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.70530749
133insulin secretion (GO:0030073)2.68129590
134phospholipid dephosphorylation (GO:0046839)2.67553992
135endocrine pancreas development (GO:0031018)2.67260146
136chemosensory behavior (GO:0007635)2.66943273
137positive regulation of vasculogenesis (GO:2001214)2.66671525
138nodal signaling pathway (GO:0038092)2.66159966
139cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.65802534
140positive regulation of glomerulus development (GO:0090193)2.64984695
141positive regulation of heat generation (GO:0031652)2.63855879
142cell differentiation involved in metanephros development (GO:0072202)2.63649089
143positive regulation of catenin import into nucleus (GO:0035413)2.61602331
144tonic smooth muscle contraction (GO:0014820)2.57582069
145positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.57345566
146positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.56208482
147phosphatidylinositol dephosphorylation (GO:0046856)2.51321010
148regulation of Rac protein signal transduction (GO:0035020)2.49970942
149positive regulation of glucose metabolic process (GO:0010907)2.49274313
150epithelial cell fate commitment (GO:0072148)2.46984813
151iron ion import (GO:0097286)2.45855527
152regulation of protein localization to cell surface (GO:2000008)2.43028334
153glomerular visceral epithelial cell development (GO:0072015)2.42902076
154regulation of fever generation (GO:0031620)2.40922429
155positive regulation of glycogen metabolic process (GO:0070875)2.40114007
156cellular potassium ion homeostasis (GO:0030007)2.39968676
157endosome to melanosome transport (GO:0035646)2.39845534
158endosome to pigment granule transport (GO:0043485)2.39845534
159response to copper ion (GO:0046688)2.39743049
160positive regulation of carbohydrate metabolic process (GO:0045913)2.39194423
161renal system process (GO:0003014)2.36366797
162potassium ion homeostasis (GO:0055075)2.36338539
163relaxation of cardiac muscle (GO:0055119)2.35771495
164negative regulation of metanephros development (GO:0072217)2.35232508
165negative regulation of humoral immune response (GO:0002921)2.35051260
166nephron tubule formation (GO:0072079)2.33801031
167nitric oxide biosynthetic process (GO:0006809)2.33593667
168toxin metabolic process (GO:0009404)2.33282159
169positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.32789642

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.12126702
2GBX2_23144817_ChIP-Seq_PC3_Human3.02927265
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.62961499
4IGF1R_20145208_ChIP-Seq_DFB_Human2.50445744
5VDR_22108803_ChIP-Seq_LS180_Human2.18681969
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.16473063
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.13720594
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.94371893
9PIAS1_25552417_ChIP-Seq_VCAP_Human1.92205517
10CDX2_19796622_ChIP-Seq_MESCs_Mouse1.90275003
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86211906
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.83288525
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.81506231
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80824117
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.76869776
16* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70915672
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.70724719
18CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.69391434
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.67220274
20GATA1_22025678_ChIP-Seq_K562_Human1.64348372
21RXR_22158963_ChIP-Seq_LIVER_Mouse1.63693100
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.60119514
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57885406
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.56708597
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.54110971
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53689072
27* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.50886359
28* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.50886359
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47710824
30DROSHA_22980978_ChIP-Seq_HELA_Human1.46202317
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44561438
32* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42607408
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41495945
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41277907
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.41145335
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.39844445
37AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.38985839
38LXR_22158963_ChIP-Seq_LIVER_Mouse1.36461215
39HTT_18923047_ChIP-ChIP_STHdh_Human1.36379957
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.36094215
41SOX2_20726797_ChIP-Seq_SW620_Human1.35996282
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.34793538
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.34029087
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32555738
45TAF15_26573619_Chip-Seq_HEK293_Human1.32348898
46EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32258761
47FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.32154088
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31574062
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.31536434
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31244150
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29797224
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28922055
53* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.26674227
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26319559
55CDX2_20551321_ChIP-Seq_CACO-2_Human1.25727958
56P300_19829295_ChIP-Seq_ESCs_Human1.24973723
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24839302
58ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23943779
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22456792
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22360952
61AR_25329375_ChIP-Seq_VCAP_Human1.21240433
62* SMAD3_21741376_ChIP-Seq_HESCs_Human1.21193565
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20421490
64SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19725688
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.19315864
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19002921
67* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18655627
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18625509
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.18452996
70* CDX2_22108803_ChIP-Seq_LS180_Human1.17929734
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17223681
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17155955
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17155955
74TCF4_23295773_ChIP-Seq_U87_Human1.16510425
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.16458160
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15813403
77FOXA1_25552417_ChIP-Seq_VCAP_Human1.15749416
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15478435
79STAT3_18555785_Chip-Seq_ESCs_Mouse1.14325769
80PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13990690
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13032762
82EZH2_22144423_ChIP-Seq_EOC_Human1.12947464
83* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10370588
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09807183
85AHR_22903824_ChIP-Seq_MCF-7_Human1.08727036
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07552357
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07449926
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06264213
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04960595
90ER_23166858_ChIP-Seq_MCF-7_Human1.04909427
91* SMAD4_21741376_ChIP-Seq_HESCs_Human1.04511815
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.04402922
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04324814
94FUS_26573619_Chip-Seq_HEK293_Human1.04161406
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.04142200
96TP63_23658742_ChIP-Seq_EP156T_Human1.03990766
97TP53_18474530_ChIP-ChIP_U2OS_Human1.03282970
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02209229
99WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01599771
100CBX2_27304074_Chip-Seq_ESCs_Mouse1.01476398
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.01170860
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.00802569
103NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00750621
104NFE2_27457419_Chip-Seq_LIVER_Mouse0.99603419
105SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99117174
106NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99113129
107EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99043230
108EZH2_27294783_Chip-Seq_NPCs_Mouse0.98983307
109NMYC_18555785_Chip-Seq_ESCs_Mouse0.97858019
110CJUN_26792858_Chip-Seq_BT549_Human0.97638390
111P53_22387025_ChIP-Seq_ESCs_Mouse0.97436585
112P300_18555785_Chip-Seq_ESCs_Mouse0.97111723
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97071039
114* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96576165
115KDM2B_26808549_Chip-Seq_REH_Human0.96169542
116STAT3_23295773_ChIP-Seq_U87_Human0.96009178
117EP300_21415370_ChIP-Seq_HL-1_Mouse0.95849192
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95208547
119OCT4_18555785_Chip-Seq_ESCs_Mouse0.95019083
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94923222
121E2F1_18555785_Chip-Seq_ESCs_Mouse0.94916329
122KLF4_18555785_Chip-Seq_ESCs_Mouse0.93648132
123FOXA2_19822575_ChIP-Seq_HepG2_Human0.93579683
124EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93553755
125RXR_22108803_ChIP-Seq_LS180_Human0.92677265
126P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92614892
127CMYC_18555785_Chip-Seq_ESCs_Mouse0.92571423
128BCAT_22108803_ChIP-Seq_LS180_Human0.92388454
129TAL1_26923725_Chip-Seq_HPCs_Mouse0.91855174
130SMAD3_21741376_ChIP-Seq_EPCs_Human0.91632143
131SOX2_18555785_Chip-Seq_ESCs_Mouse0.91520847
132RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90802333
133RNF2_27304074_Chip-Seq_ESCs_Mouse0.90741325
134SMAD4_21741376_ChIP-Seq_EPCs_Human0.89630278
135* TCF4_22108803_ChIP-Seq_LS180_Human0.89470942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation6.92823995
2MP0005360_urolithiasis5.59663394
3* MP0004019_abnormal_vitamin_homeostasis4.90644512
4MP0005332_abnormal_amino_acid4.53381513
5MP0003195_calcinosis4.12381871
6* MP0001765_abnormal_ion_homeostasis3.87309962
7MP0002138_abnormal_hepatobiliary_system3.79235421
8MP0009643_abnormal_urine_homeostasis3.69081911
9MP0002139_abnormal_hepatobiliary_system3.32819572
10MP0005636_abnormal_mineral_homeostasis3.05672826
11MP0010234_abnormal_vibrissa_follicle2.95238615
12MP0001756_abnormal_urination2.84356851
13MP0002136_abnormal_kidney_physiology2.79850173
14MP0008004_abnormal_stomach_pH2.72475470
15MP0002909_abnormal_adrenal_gland2.59101887
16MP0003878_abnormal_ear_physiology2.52083272
17MP0005377_hearing/vestibular/ear_phenot2.52083272
18MP0005058_abnormal_lysosome_morphology2.42183843
19MP0003011_delayed_dark_adaptation2.36125993
20MP0003252_abnormal_bile_duct2.18525244
21MP0002837_dystrophic_cardiac_calcinosis2.16021473
22MP0008875_abnormal_xenobiotic_pharmacok1.90259057
23MP0004885_abnormal_endolymph1.86553805
24MP0010368_abnormal_lymphatic_system1.79663967
25MP0002928_abnormal_bile_duct1.78306878
26MP0000569_abnormal_digit_pigmentation1.78226082
27MP0000538_abnormal_urinary_bladder1.76382263
28MP0002876_abnormal_thyroid_physiology1.76217632
29MP0004215_abnormal_myocardial_fiber1.71978395
30MP0002254_reproductive_system_inflammat1.61183331
31MP0001501_abnormal_sleep_pattern1.61105447
32MP0008961_abnormal_basal_metabolism1.51839284
33MP0010678_abnormal_skin_adnexa1.51227229
34MP0003172_abnormal_lysosome_physiology1.50865697
35MP0010386_abnormal_urinary_bladder1.45681996
36MP0005584_abnormal_enzyme/coenzyme_acti1.41602359
37MP0005084_abnormal_gallbladder_morpholo1.38386795
38MP0000230_abnormal_systemic_arterial1.37747973
39MP0005367_renal/urinary_system_phenotyp1.36850516
40MP0000516_abnormal_urinary_system1.36850516
41MP0002638_abnormal_pupillary_reflex1.31013900
42MP0001879_abnormal_lymphatic_vessel1.29787980
43* MP0002693_abnormal_pancreas_physiology1.29252094
44MP0005451_abnormal_body_composition1.23228671
45MP0005085_abnormal_gallbladder_physiolo1.23065971
46* MP0001958_emphysema1.21958471
47MP0005646_abnormal_pituitary_gland1.19634222
48MP0003300_gastrointestinal_ulcer1.18453329
49MP0003045_fibrosis1.15987966
50MP0004742_abnormal_vestibular_system1.14957892
51MP0000003_abnormal_adipose_tissue1.13188871
52* MP0005535_abnormal_body_temperature1.11256652
53MP0001764_abnormal_homeostasis1.09789530
54MP0005310_abnormal_salivary_gland1.09375031
55* MP0002971_abnormal_brown_adipose1.07193060
56MP0005365_abnormal_bile_salt1.07100207
57MP0010329_abnormal_lipoprotein_level1.06975921
58MP0001270_distended_abdomen1.05770385
59MP0005448_abnormal_energy_balance1.05491511
60MP0001963_abnormal_hearing_physiology1.04049237
61MP0006054_spinal_hemorrhage1.00931598
62MP0004510_myositis1.00858159
63MP0001485_abnormal_pinna_reflex1.00194044
64MP0005670_abnormal_white_adipose0.99728984
65MP0002896_abnormal_bone_mineralization0.97417693
66MP0000920_abnormal_myelination0.95428223
67MP0002735_abnormal_chemical_nociception0.95281458
68MP0002064_seizures0.94333052
69MP0003950_abnormal_plasma_membrane0.93436558
70MP0004147_increased_porphyrin_level0.91430754
71MP0004859_abnormal_synaptic_plasticity0.90172551
72MP0002135_abnormal_kidney_morphology0.89028340
73* MP0003186_abnormal_redox_activity0.87505015
74MP0000383_abnormal_hair_follicle0.87318285
75MP0001664_abnormal_digestion0.87157880
76MP0003879_abnormal_hair_cell0.86844039
77MP0000678_abnormal_parathyroid_gland0.86593671
78MP0003283_abnormal_digestive_organ0.84902355
79MP0003646_muscle_fatigue0.84651420
80MP0006036_abnormal_mitochondrial_physio0.84183437
81MP0001661_extended_life_span0.81900107
82MP0009046_muscle_twitch0.81605104
83MP0009780_abnormal_chondrocyte_physiolo0.81504268
84MP0009745_abnormal_behavioral_response0.80849803
85MP0003638_abnormal_response/metabolism_0.79758612
86MP0002938_white_spotting0.78409067
87MP0002163_abnormal_gland_morphology0.78187057
88MP0003329_amyloid_beta_deposits0.77422745
89MP0005319_abnormal_enzyme/_coenzyme0.77272819
90MP0003868_abnormal_feces_composition0.75992577
91* MP0002168_other_aberrant_phenotype0.75163278
92MP0001177_atelectasis0.73982041
93* MP0003633_abnormal_nervous_system0.73405123
94MP0009840_abnormal_foam_cell0.73385432
95MP0003690_abnormal_glial_cell0.72575151
96MP0006072_abnormal_retinal_apoptosis0.72348144
97MP0001984_abnormal_olfaction0.71476964
98MP0002067_abnormal_sensory_capabilities0.71335096
99MP0002069_abnormal_eating/drinking_beha0.71315635
100MP0005408_hypopigmentation0.71282131
101MP0009642_abnormal_blood_homeostasis0.71187349
102MP0003303_peritoneal_inflammation0.69893890
103MP0004142_abnormal_muscle_tone0.69280975
104MP0003122_maternal_imprinting0.68723645
105MP0001486_abnormal_startle_reflex0.68300076
106MP0004085_abnormal_heartbeat0.68058386
107MP0000371_diluted_coat_color0.68023998
108* MP0003953_abnormal_hormone_level0.66669893
109MP0001440_abnormal_grooming_behavior0.66566763
110MP0004484_altered_response_of0.66285228
111MP0005220_abnormal_exocrine_pancreas0.65894879
112MP0002118_abnormal_lipid_homeostasis0.65323242
113* MP0005375_adipose_tissue_phenotype0.64662033
114MP0004270_analgesia0.64553015
115MP0005620_abnormal_muscle_contractility0.63569331
116MP0009764_decreased_sensitivity_to0.63463628
117MP0005330_cardiomyopathy0.63417355
118MP0000026_abnormal_inner_ear0.62206594
119MP0005551_abnormal_eye_electrophysiolog0.61113623
120MP0002127_abnormal_cardiovascular_syste0.60902911
121MP0005645_abnormal_hypothalamus_physiol0.59317841
122MP0003959_abnormal_lean_body0.59081256
123MP0003787_abnormal_imprinting0.58029583
124MP0004924_abnormal_behavior0.57482059
125MP0005386_behavior/neurological_phenoty0.57482059
126MP0005165_increased_susceptibility_to0.56600623
127* MP0005395_other_phenotype0.56510967
128MP0005452_abnormal_adipose_tissue0.56334272
129MP0003635_abnormal_synaptic_transmissio0.54939662
130* MP0002229_neurodegeneration0.54322513
131MP0002272_abnormal_nervous_system0.53763875
132MP0004272_abnormal_basement_membrane0.52255506
133MP0000013_abnormal_adipose_tissue0.51834111
134* MP0002078_abnormal_glucose_homeostasis0.51480924
135MP0005379_endocrine/exocrine_gland_phen0.51010864
136MP0002572_abnormal_emotion/affect_behav0.50786753
137MP0002066_abnormal_motor_capabilities/c0.49842618
138MP0005409_darkened_coat_color0.49645351
139MP0003191_abnormal_cellular_cholesterol0.49137625
140MP0000372_irregular_coat_pigmentation0.48592320
141MP0000778_abnormal_nervous_system0.48419835
142MP0002734_abnormal_mechanical_nocicepti0.48281576
143MP0002295_abnormal_pulmonary_circulatio0.48224356
144* MP0001944_abnormal_pancreas_morphology0.48207464
145MP0005167_abnormal_blood-brain_barrier0.47129796
146MP0008469_abnormal_protein_level0.45897670

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)8.25762911
2Hypokalemic alkalosis (HP:0001949)7.59647283
3Metabolic alkalosis (HP:0200114)7.38487201
4Hypomagnesemia (HP:0002917)7.01106226
5Hyperactive renin-angiotensin system (HP:0000841)6.91692816
6Polyuria (HP:0000103)6.54989831
7Abnormality of chloride homeostasis (HP:0011422)6.31965455
8Abnormal urine output (HP:0012590)6.18453875
9Abnormality of magnesium homeostasis (HP:0004921)5.93943253
10Gout (HP:0001997)5.77471022
11* Abnormality of renal excretion (HP:0011036)5.55386640
12Abnormal drinking behavior (HP:0030082)5.50966536
13Polydipsia (HP:0001959)5.50966536
14Abnormality of renin-angiotensin system (HP:0000847)5.24387955
15Proximal tubulopathy (HP:0000114)5.05428253
16Tetany (HP:0001281)4.92793528
17Hyperaldosteronism (HP:0000859)4.89718963
18Alkalosis (HP:0001948)4.77353074
19Hyperuricemia (HP:0002149)4.70070615
20Increased purine levels (HP:0004368)4.70070615
21Renal salt wasting (HP:0000127)4.64922289
22Generalized aminoaciduria (HP:0002909)4.31197986
23* Hyperphosphatemia (HP:0002905)4.14906266
24Hypokalemia (HP:0002900)4.09031436
25Abnormality of purine metabolism (HP:0004352)3.97157911
26Hyperglycinuria (HP:0003108)3.88658906
27Hypercalciuria (HP:0002150)3.79529961
28Glycosuria (HP:0003076)3.77865136
29Abnormality of urine glucose concentration (HP:0011016)3.77865136
30Abnormality of glutamine family amino acid metabolism (HP:0010902)3.64304519
31Abnormality of potassium homeostasis (HP:0011042)3.54040027
32Ketoacidosis (HP:0001993)3.46399939
33Tubular atrophy (HP:0000092)3.40193554
34Renal tubular acidosis (HP:0001947)3.34002752
35Hyperphosphaturia (HP:0003109)3.18709926
36Abnormal urine phosphate concentration (HP:0012599)3.08842527
37Abnormality of glycine metabolism (HP:0010895)3.05244785
38Abnormality of serine family amino acid metabolism (HP:0010894)3.05244785
39Delayed epiphyseal ossification (HP:0002663)2.93979480
40Ketosis (HP:0001946)2.77348899
41Abnormality of nucleobase metabolism (HP:0010932)2.77129524
42Hypophosphatemia (HP:0002148)2.74132083
43* Nephrocalcinosis (HP:0000121)2.72346189
44Vacuolated lymphocytes (HP:0001922)2.61492053
45Widely patent fontanelles and sutures (HP:0004492)2.53229863
46Renal tubular dysfunction (HP:0000124)2.52462455
47Hyponatremia (HP:0002902)2.51878826
48Rickets (HP:0002748)2.47534041
49Enlarged kidneys (HP:0000105)2.46692606
50Hydroxyprolinuria (HP:0003080)2.45962775
51Abnormality of proline metabolism (HP:0010907)2.45962775
52Nephrolithiasis (HP:0000787)2.44629384
53Decreased circulating renin level (HP:0003351)2.42729927
54Abnormality of sodium homeostasis (HP:0010931)2.41933430
55Dehydration (HP:0001944)2.38601562
56Hypotension (HP:0002615)2.36305385
57Abnormality of fatty-acid metabolism (HP:0004359)2.34843769
58Abnormality of vitamin B metabolism (HP:0004340)2.34388142
59Abnormality of aromatic amino acid family metabolism (HP:0004338)2.32853362
60Urethral obstruction (HP:0000796)2.30474480
61* Abnormality of renal resorption (HP:0011038)2.24988301
62Adrenal overactivity (HP:0002717)2.16514609
63Hypoplasia of the uterus (HP:0000013)2.15215452
64Abnormality of vitamin metabolism (HP:0100508)2.12152855
65Hyperkalemia (HP:0002153)2.11931919
66Delayed CNS myelination (HP:0002188)2.11733965
67Abnormality of aspartate family amino acid metabolism (HP:0010899)2.09927625
68Large eyes (HP:0001090)2.08446707
69Dysostosis multiplex (HP:0000943)2.07865536
70Confusion (HP:0001289)2.07580141
71Abnormality of calcium-phosphate metabolism (HP:0100530)2.04916041
72Metaphyseal irregularity (HP:0003025)2.03566425
73Hypothermia (HP:0002045)2.01850024
74J-shaped sella turcica (HP:0002680)2.00601774
75Methylmalonic aciduria (HP:0012120)1.98945135
76Potter facies (HP:0002009)1.98433265
77Facial shape deformation (HP:0011334)1.98433265
78Increased CSF protein (HP:0002922)1.98210140
79Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95666266
80Hyperglycinemia (HP:0002154)1.91306387
81Large for gestational age (HP:0001520)1.91111807
82Abnormal enzyme/coenzyme activity (HP:0012379)1.90861493
83Vomiting (HP:0002013)1.90505461
84Septate vagina (HP:0001153)1.88876035
85Hypophosphatemic rickets (HP:0004912)1.88690271
86Metabolic acidosis (HP:0001942)1.87821538
87Abnormality of the costochondral junction (HP:0000919)1.86636406
88Hypoparathyroidism (HP:0000829)1.86081419
89Axonal loss (HP:0003447)1.85307889
90Abnormal pancreas size (HP:0012094)1.84788898
91Metaphyseal dysplasia (HP:0100255)1.84526647
92Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82890656
93Abnormality of alkaline phosphatase activity (HP:0004379)1.82719300
94Fair hair (HP:0002286)1.82660103
95Bicornuate uterus (HP:0000813)1.81781805
96Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81077923
97Dicarboxylic aciduria (HP:0003215)1.81077923
98Nephrogenic diabetes insipidus (HP:0009806)1.77548746
99Metaphyseal cupping (HP:0003021)1.76846072
100Tetraparesis (HP:0002273)1.76426378
101Tubulointerstitial abnormality (HP:0001969)1.74647779
102Lethargy (HP:0001254)1.73969585
103Abnormal eating behavior (HP:0100738)1.71519460
104Mucopolysacchariduria (HP:0008155)1.70868795
105Urinary glycosaminoglycan excretion (HP:0003541)1.70868795
106Abnormality of Sharpey fibers (HP:0100685)1.69980650
107Polyphagia (HP:0002591)1.68339598
108Tubulointerstitial fibrosis (HP:0005576)1.68287964
109Chondrocalcinosis (HP:0000934)1.68183582
110Abnormal tarsal ossification (HP:0008369)1.67685011
111Tachypnea (HP:0002789)1.67605515
112Generalized muscle weakness (HP:0003324)1.67471484
113Hyperventilation (HP:0002883)1.66839015
114Persistence of primary teeth (HP:0006335)1.65596783
115Bilateral sensorineural hearing impairment (HP:0008619)1.64693438
116Abnormality of glycosaminoglycan metabolism (HP:0004371)1.63750989
117Abnormality of mucopolysaccharide metabolism (HP:0011020)1.63750989
118Abnormality of the renal cortex (HP:0011035)1.61481219
119Abnormality of liposaccharide metabolism (HP:0010968)1.61320263
120Abnormality of glycosphingolipid metabolism (HP:0004343)1.61320263
121Abnormality of glycolipid metabolism (HP:0010969)1.61320263
122Hypocalcemia (HP:0002901)1.59850676
123Nuclear cataract (HP:0100018)1.53995624
124Abnormality of the renal medulla (HP:0100957)1.52125032
125Abnormality of polysaccharide metabolism (HP:0011012)1.50198107
126Progressive neurologic deterioration (HP:0002344)1.45599393
127Volvulus (HP:0002580)1.42084973
128Generalized hypopigmentation of hair (HP:0011358)1.41983863
129Methylmalonic acidemia (HP:0002912)1.41426687
130Agitation (HP:0000713)1.39327549
131Hypoalbuminemia (HP:0003073)1.38563119
132Abnormal albumin level (HP:0012116)1.38563119
133Cardiomegaly (HP:0001640)1.36489311
134Abnormality of the vitamin B12 metabolism (HP:0004341)1.34972828
135Insulin-resistant diabetes mellitus (HP:0000831)1.34886490
136Growth hormone excess (HP:0000845)1.34279012
137Intestinal atresia (HP:0011100)1.33429957
138Albinism (HP:0001022)1.32662413
139Conjugated hyperbilirubinemia (HP:0002908)1.32038909
140Prominent supraorbital ridges (HP:0000336)1.31501033
141Exotropia (HP:0000577)1.31243813
142Mitral stenosis (HP:0001718)1.29547087
143Zonular cataract (HP:0010920)1.29274145

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK49.53363811
2OXSR16.99276573
3WNK36.49974819
4STK396.17423774
5WNK12.37370193
6ACVR1B2.06659586
7KDR2.05942403
8MAPK151.84912428
9SGK4941.79118873
10SGK2231.79118873
11STK38L1.59495782
12BCKDK1.41236105
13MST41.34458292
14INSRR1.31399439
15DAPK21.29720757
16MAP2K61.28173593
17MAP3K31.22302098
18MAP3K21.19887270
19FGFR31.13876321
20SGK21.05818330
21NLK1.03275317
22MAP4K21.03246579
23STK241.00639927
24MAP3K60.97618440
25TRPM70.97344269
26TGFBR20.91930946
27EPHA40.91009215
28MYLK0.90580053
29STK380.89435063
30PHKG10.87888644
31PHKG20.87888644
32EPHB10.87457128
33TESK10.86325406
34PTK60.85550987
35PDK20.84530477
36GRK10.80569930
37CASK0.80074689
38EPHA30.78281089
39TAOK10.77473099
40SGK30.76190952
41TNIK0.75692243
42MAP3K120.74502596
43GRK70.74143001
44CAMKK20.73174759
45SGK10.72961353
46IRAK30.72742314
47RIPK10.68716711
48GSK3A0.66697354
49PDK30.65653524
50PDK40.65653524
51NTRK30.62722073
52PIK3CG0.61765978
53PDPK10.60840944
54MST1R0.60148571
55FRK0.60147663
56MELK0.59288473
57PRKCQ0.57996316
58YES10.57295101
59PIK3CA0.55623389
60RIPK40.54602268
61MAP2K70.50500298
62NEK60.50456636
63PINK10.48788455
64STK30.48727541
65TIE10.47974367
66PDK10.47810947
67MAPK70.46892614
68IRAK20.46361398
69MAP3K70.45316082
70CCNB10.45296670
71IRAK10.45008914
72PKN10.44334687
73MAP2K10.43243183
74BRD40.43225611
75LIMK10.42560886
76BMPR20.42409599
77PRKAA20.41554076
78AKT30.40099183
79PRKCE0.39517957
80PRKAA10.39025337
81MAP3K140.38730429
82KSR10.38667852
83AKT20.38196718
84PRKD20.38091731
85CAMK2B0.38075222
86PAK30.37149241
87NTRK10.36878420
88MAP2K40.36518785
89MAPKAPK30.36159929
90CDC42BPA0.35736236
91STK110.34244428
92TAOK30.34118928
93MAPK130.31541748
94ADRBK20.31430057
95ROCK10.31392504
96PRKACA0.31158799
97PRKCH0.31043203
98PTK2B0.30969598
99MAP3K10.29793832
100PRKG20.29441861
101JAK10.29409201
102PRKCG0.28141483
103PRKCZ0.27814273
104PRKCA0.26869466
105EIF2AK30.26688613
106CAMK2A0.24938032
107CDK50.24723791
108ABL20.24586708
109PRKCD0.24007879
110NEK90.23776309
111BRSK20.23582029
112CSNK1A10.23144289
113PTK20.21476909
114KSR20.21061668
115NME10.20372515
116OBSCN0.19861121
117DYRK1B0.19466712
118PRKACG0.18704096
119MINK10.18581849
120HIPK20.18403245
121CAMK40.18058419
122INSR0.18024929
123UHMK10.17249574
124TNK20.16997841
125BLK0.16974284
126EGFR0.16521141
127CDK30.16134677
128MET0.15808836
129DMPK0.15686751
130JAK20.15561291
131IRAK40.14980021
132CAMK2D0.14263660
133PRKD30.14051200
134FER0.13705229
135ADRBK10.13262419
136FGFR20.12933398
137FGFR40.12543849
138DYRK1A0.12462244
139PNCK0.12371953
140FES0.11917881
141MAP3K40.11198110
142CAMK2G0.10261461
143PRKG10.09900606
144RET0.09621978
145MAPK120.09584135
146GRK50.08873501
147SRC0.08748752
148NEK10.08558811

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006503.65722548
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.43148966
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.28409881
4Propanoate metabolism_Homo sapiens_hsa006403.06027127
5Cyanoamino acid metabolism_Homo sapiens_hsa004603.05957602
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.95088307
7Collecting duct acid secretion_Homo sapiens_hsa049662.88850356
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.59068359
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.37857856
10Vitamin digestion and absorption_Homo sapiens_hsa049772.35958892
11Peroxisome_Homo sapiens_hsa041462.27285915
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.21757546
13Circadian rhythm_Homo sapiens_hsa047102.17727649
14Other glycan degradation_Homo sapiens_hsa005111.98511606
15Tryptophan metabolism_Homo sapiens_hsa003801.96617129
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.86120984
17Mineral absorption_Homo sapiens_hsa049781.83864900
18beta-Alanine metabolism_Homo sapiens_hsa004101.83660309
19Sulfur metabolism_Homo sapiens_hsa009201.81477480
20Fatty acid degradation_Homo sapiens_hsa000711.81360373
21* Pentose and glucuronate interconversions_Homo sapiens_hsa000401.79841685
22Pyruvate metabolism_Homo sapiens_hsa006201.78008274
23Bile secretion_Homo sapiens_hsa049761.70306739
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61603055
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.60880537
26Fatty acid metabolism_Homo sapiens_hsa012121.53764985
27* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49223196
28Protein digestion and absorption_Homo sapiens_hsa049741.48592737
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.45087175
30Fatty acid elongation_Homo sapiens_hsa000621.40723430
31Dorso-ventral axis formation_Homo sapiens_hsa043201.38156222
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37563822
33Arginine and proline metabolism_Homo sapiens_hsa003301.33814968
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.32512538
35Glutathione metabolism_Homo sapiens_hsa004801.28301819
36Oxidative phosphorylation_Homo sapiens_hsa001901.28251897
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.27258762
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.24399860
39Lysosome_Homo sapiens_hsa041421.18302820
40Histidine metabolism_Homo sapiens_hsa003401.18005939
41Gastric acid secretion_Homo sapiens_hsa049711.17993683
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17644800
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05398759
44Complement and coagulation cascades_Homo sapiens_hsa046101.02033879
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97943878
46Glucagon signaling pathway_Homo sapiens_hsa049220.94101605
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93653045
48Carbon metabolism_Homo sapiens_hsa012000.93381458
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92055315
50Lysine degradation_Homo sapiens_hsa003100.91697350
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90507655
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85793556
53Retinol metabolism_Homo sapiens_hsa008300.84651863
54Type II diabetes mellitus_Homo sapiens_hsa049300.84541181
55Vibrio cholerae infection_Homo sapiens_hsa051100.84446015
56Synaptic vesicle cycle_Homo sapiens_hsa047210.84120616
57PPAR signaling pathway_Homo sapiens_hsa033200.82869015
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81899695
59Phenylalanine metabolism_Homo sapiens_hsa003600.81553574
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.80755367
61Thyroid hormone synthesis_Homo sapiens_hsa049180.80634014
62Arachidonic acid metabolism_Homo sapiens_hsa005900.79415077
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.78858308
64Sphingolipid metabolism_Homo sapiens_hsa006000.78276277
65Protein export_Homo sapiens_hsa030600.78106717
66Glycerolipid metabolism_Homo sapiens_hsa005610.77521029
67Insulin resistance_Homo sapiens_hsa049310.73254541
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72136719
69Renin-angiotensin system_Homo sapiens_hsa046140.69136019
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68272946
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66970649
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64060596
73Circadian entrainment_Homo sapiens_hsa047130.62715469
74Parkinsons disease_Homo sapiens_hsa050120.61931905
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60494542
76Long-term depression_Homo sapiens_hsa047300.59231027
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.58965280
78Folate biosynthesis_Homo sapiens_hsa007900.57771878
79* Starch and sucrose metabolism_Homo sapiens_hsa005000.54427999
80Nitrogen metabolism_Homo sapiens_hsa009100.54366844
81* Metabolic pathways_Homo sapiens_hsa011000.54087355
82Rheumatoid arthritis_Homo sapiens_hsa053230.53519384
83Fatty acid biosynthesis_Homo sapiens_hsa000610.53461652
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53169966
85Insulin secretion_Homo sapiens_hsa049110.52556131
86Alzheimers disease_Homo sapiens_hsa050100.51346930
87Arginine biosynthesis_Homo sapiens_hsa002200.51285883
88Phototransduction_Homo sapiens_hsa047440.50494179
89Type I diabetes mellitus_Homo sapiens_hsa049400.50082251
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.49635114
91Choline metabolism in cancer_Homo sapiens_hsa052310.49291759
92Ovarian steroidogenesis_Homo sapiens_hsa049130.48533579
93Regulation of autophagy_Homo sapiens_hsa041400.47848138
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47135188
95ABC transporters_Homo sapiens_hsa020100.46854400
96Tight junction_Homo sapiens_hsa045300.46437604
97cAMP signaling pathway_Homo sapiens_hsa040240.45960155
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45952453
99Inositol phosphate metabolism_Homo sapiens_hsa005620.45393664
100Salivary secretion_Homo sapiens_hsa049700.45166072
101Ether lipid metabolism_Homo sapiens_hsa005650.43646343
102Insulin signaling pathway_Homo sapiens_hsa049100.42381518
103FoxO signaling pathway_Homo sapiens_hsa040680.41978095
104Taste transduction_Homo sapiens_hsa047420.41761297
105Nicotine addiction_Homo sapiens_hsa050330.41693091
106Dopaminergic synapse_Homo sapiens_hsa047280.41231477
107Ras signaling pathway_Homo sapiens_hsa040140.40523445
108Steroid biosynthesis_Homo sapiens_hsa001000.40507363
109Vitamin B6 metabolism_Homo sapiens_hsa007500.40203335
110Hepatitis C_Homo sapiens_hsa051600.40082310
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39944841
112GABAergic synapse_Homo sapiens_hsa047270.38177694
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.37721632
114Fructose and mannose metabolism_Homo sapiens_hsa000510.37681191
115Selenocompound metabolism_Homo sapiens_hsa004500.36403649
116Cardiac muscle contraction_Homo sapiens_hsa042600.36382270
117Calcium signaling pathway_Homo sapiens_hsa040200.35731740
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.34152357
119Chemical carcinogenesis_Homo sapiens_hsa052040.33707478
120Linoleic acid metabolism_Homo sapiens_hsa005910.32991580
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32238965
122Tyrosine metabolism_Homo sapiens_hsa003500.30636733
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30032896
124Pancreatic secretion_Homo sapiens_hsa049720.27802968
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25929032
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25432962
127Serotonergic synapse_Homo sapiens_hsa047260.24204304
128Huntingtons disease_Homo sapiens_hsa050160.23208326
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21263252
130Morphine addiction_Homo sapiens_hsa050320.18721427
131Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.18004732
132Renin secretion_Homo sapiens_hsa049240.17869937
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17396291
134Glutamatergic synapse_Homo sapiens_hsa047240.16440998
135Phagosome_Homo sapiens_hsa041450.15411633

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