KLC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named 'kinesin 2', this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.34165659
2pyrimidine nucleobase catabolic process (GO:0006208)6.09391019
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.05481418
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.58661182
5locomotory exploration behavior (GO:0035641)5.53043513
6synaptic vesicle exocytosis (GO:0016079)5.30717474
7glutamate secretion (GO:0014047)5.19987767
8regulation of synaptic vesicle exocytosis (GO:2000300)5.04069698
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.02191705
10vocalization behavior (GO:0071625)4.91467289
11establishment of mitochondrion localization (GO:0051654)4.91236566
12nucleobase catabolic process (GO:0046113)4.85468958
13layer formation in cerebral cortex (GO:0021819)4.78504291
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.77884120
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.69936915
16regulation of synaptic vesicle transport (GO:1902803)4.45250194
17regulation of glutamate receptor signaling pathway (GO:1900449)4.44293735
18regulation of synapse structural plasticity (GO:0051823)4.43948046
19exploration behavior (GO:0035640)4.43652978
20neurotransmitter secretion (GO:0007269)4.35909148
21neuronal action potential propagation (GO:0019227)4.29653457
22regulation of neuronal synaptic plasticity (GO:0048168)4.20050568
23proline transport (GO:0015824)4.12886419
24negative regulation of synaptic transmission, GABAergic (GO:0032229)4.08661735
25sodium ion export (GO:0071436)4.06826069
26neuron cell-cell adhesion (GO:0007158)4.04412371
27cellular potassium ion homeostasis (GO:0030007)4.00943684
28regulation of long-term neuronal synaptic plasticity (GO:0048169)4.00922775
29ionotropic glutamate receptor signaling pathway (GO:0035235)3.96178090
30* protein localization to synapse (GO:0035418)3.92159438
31mitochondrion transport along microtubule (GO:0047497)3.90990922
32establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.90990922
33dendritic spine morphogenesis (GO:0060997)3.88579039
34activation of protein kinase A activity (GO:0034199)3.86031574
35cell migration in hindbrain (GO:0021535)3.85753045
36presynaptic membrane organization (GO:0097090)3.84825380
37cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.72863562
38gamma-aminobutyric acid transport (GO:0015812)3.72119968
39cell communication by electrical coupling (GO:0010644)3.72044373
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.68852862
41synaptic transmission, glutamatergic (GO:0035249)3.63267133
42dendrite morphogenesis (GO:0048813)3.60341879
43presynaptic membrane assembly (GO:0097105)3.59943408
44neuromuscular process controlling balance (GO:0050885)3.58679430
45positive regulation of dendritic spine morphogenesis (GO:0061003)3.55634805
46positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.52809898
47positive regulation of synapse maturation (GO:0090129)3.52190872
48cerebellar Purkinje cell differentiation (GO:0021702)3.51529749
49neurofilament cytoskeleton organization (GO:0060052)3.51490097
50glutamate receptor signaling pathway (GO:0007215)3.51039635
51neuron recognition (GO:0008038)3.50091053
52negative regulation of microtubule polymerization (GO:0031115)3.48494804
53regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.48165862
54neurotransmitter-gated ion channel clustering (GO:0072578)3.47391055
55negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.46255906
56cerebellar granule cell differentiation (GO:0021707)3.44568407
57neurotransmitter transport (GO:0006836)3.42448710
58synaptic vesicle endocytosis (GO:0048488)3.41067496
59response to pheromone (GO:0019236)3.39821414
60neuron-neuron synaptic transmission (GO:0007270)3.39355466
61regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.39163922
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.38966891
63positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.38441294
64long-term memory (GO:0007616)3.37536798
65membrane depolarization during action potential (GO:0086010)3.36534975
66axonal fasciculation (GO:0007413)3.36133470
67regulation of excitatory postsynaptic membrane potential (GO:0060079)3.31644412
68positive regulation of synaptic transmission, GABAergic (GO:0032230)3.31636738
69positive regulation of membrane potential (GO:0045838)3.30586064
70vesicle transport along microtubule (GO:0047496)3.28292668
71axon cargo transport (GO:0008088)3.28064248
72regulation of neurotransmitter secretion (GO:0046928)3.26730633
73glycine transport (GO:0015816)3.25059055
74neuromuscular process controlling posture (GO:0050884)3.21900613
75regulation of dendritic spine morphogenesis (GO:0061001)3.21766962
76innervation (GO:0060384)3.21647937
77regulation of synaptic plasticity (GO:0048167)3.21485729
78positive regulation of synapse assembly (GO:0051965)3.20164115
79adult walking behavior (GO:0007628)3.20113172
80regulation of postsynaptic membrane potential (GO:0060078)3.19920141
81regulation of synapse maturation (GO:0090128)3.18096181
82organelle transport along microtubule (GO:0072384)3.16670998
83regulation of neurotransmitter levels (GO:0001505)3.16397319
84regulation of voltage-gated calcium channel activity (GO:1901385)3.14344407
85axon extension (GO:0048675)3.12667906
86regulation of vesicle fusion (GO:0031338)3.12153084
87prepulse inhibition (GO:0060134)3.08030123
88positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.06649053
89synapse organization (GO:0050808)3.06346984
90response to auditory stimulus (GO:0010996)3.05903180
91establishment of synaptic vesicle localization (GO:0097480)3.05377151
92synaptic vesicle transport (GO:0048489)3.05377151
93central nervous system projection neuron axonogenesis (GO:0021952)3.04374796
94positive regulation of potassium ion transmembrane transport (GO:1901381)3.02828924
95transmission of nerve impulse (GO:0019226)3.02809352
96auditory behavior (GO:0031223)3.01783401
97regulation of ARF protein signal transduction (GO:0032012)3.01532985
98mating behavior (GO:0007617)3.00922035
99mechanosensory behavior (GO:0007638)3.00895296
100membrane depolarization (GO:0051899)2.99007074
101regulation of neurotransmitter transport (GO:0051588)2.98873503
102neuronal ion channel clustering (GO:0045161)2.97810142
103regulation of synaptic transmission, glutamatergic (GO:0051966)2.96271814
104gamma-aminobutyric acid signaling pathway (GO:0007214)2.95648204
105cell communication involved in cardiac conduction (GO:0086065)2.95568947
106establishment of nucleus localization (GO:0040023)2.95111857
107neuromuscular process (GO:0050905)2.94295708
108membrane hyperpolarization (GO:0060081)2.93175307
109postsynaptic membrane organization (GO:0001941)2.92142633
110synapse assembly (GO:0007416)2.91865975
111establishment of vesicle localization (GO:0051650)2.90701818
112negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.90552773
113adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.87935699
114behavioral response to nicotine (GO:0035095)2.86180418
115neuron projection extension (GO:1990138)2.86124832
116regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.85935338
117clathrin coat assembly (GO:0048268)2.85419667
118cerebellar Purkinje cell layer development (GO:0021680)2.83206628
119positive regulation of dendritic spine development (GO:0060999)2.82803512
120G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.82758601
121cellular sodium ion homeostasis (GO:0006883)2.82181299
122dendritic spine organization (GO:0097061)2.79145889
123dopamine receptor signaling pathway (GO:0007212)2.79142362
124positive regulation of neurotransmitter transport (GO:0051590)2.78443814
125synaptic transmission (GO:0007268)2.76632359
126neuromuscular synaptic transmission (GO:0007274)2.76597710
127negative regulation of dendrite development (GO:2000171)2.76247933

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.69139696
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09646910
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03243189
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02923418
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.82725367
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.82725367
7GBX2_23144817_ChIP-Seq_PC3_Human2.79260715
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.74634766
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.73391189
10* RARB_27405468_Chip-Seq_BRAIN_Mouse2.66610155
11DROSHA_22980978_ChIP-Seq_HELA_Human2.60446526
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.59088131
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58994897
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50657625
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49713865
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.49681386
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49137852
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.46736660
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.38889329
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.36976595
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.33858292
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.25252610
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.19603204
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.17598786
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.17327894
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.14989070
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.13139998
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85271513
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.85183119
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.75844718
31AR_21572438_ChIP-Seq_LNCaP_Human1.75818074
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63695513
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59073107
34KDM2B_26808549_Chip-Seq_K562_Human1.55976507
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.50931497
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.46279299
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45063782
38ZNF274_21170338_ChIP-Seq_K562_Hela1.43671740
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42734865
40* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.39451284
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38197395
42EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38139643
43NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37231156
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36137494
45SMAD4_21799915_ChIP-Seq_A2780_Human1.35543950
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30117407
47* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29731177
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29437488
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27052230
50WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26271505
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.25772480
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.25607322
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25124692
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23494421
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.23014045
56ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23000670
57AR_19668381_ChIP-Seq_PC3_Human1.22149029
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21085215
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19337599
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16064993
61TAF15_26573619_Chip-Seq_HEK293_Human1.09550412
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09430134
63ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09036181
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08434392
65* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07449096
66AR_25329375_ChIP-Seq_VCAP_Human1.05746644
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05671527
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04764026
69CTCF_27219007_Chip-Seq_Bcells_Human1.04396227
70* TET1_21490601_ChIP-Seq_MESCs_Mouse1.02621892
71* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02006821
72* STAT3_23295773_ChIP-Seq_U87_Human1.00966796
73* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00456701
74AHR_22903824_ChIP-Seq_MCF-7_Human0.99467755
75RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98949226
76SMAD_19615063_ChIP-ChIP_OVARY_Human0.97477871
77SMAD3_21741376_ChIP-Seq_ESCs_Human0.96572249
78SMAD4_21741376_ChIP-Seq_HESCs_Human0.96340276
79TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95980736
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94992979
81* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94954648
82SMAD3_21741376_ChIP-Seq_EPCs_Human0.94915545
83BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94567455
84ARNT_22903824_ChIP-Seq_MCF-7_Human0.93803183
85CBX2_27304074_Chip-Seq_ESCs_Mouse0.93506118
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92935895
87IGF1R_20145208_ChIP-Seq_DFB_Human0.91421967
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90403688
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90202408
90P300_19829295_ChIP-Seq_ESCs_Human0.89775767
91TP53_20018659_ChIP-ChIP_R1E_Mouse0.89042749
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88877054
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87373253
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87244646
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86795454
96* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86617597
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86209477
98RNF2_27304074_Chip-Seq_NSC_Mouse0.85482638
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83312474
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83312474
101TCF4_23295773_ChIP-Seq_U87_Human0.82993820
102LXR_22292898_ChIP-Seq_THP-1_Human0.82217178
103EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.81603282
104SMAD3_21741376_ChIP-Seq_HESCs_Human0.81084300
105KLF4_19829295_ChIP-Seq_ESCs_Human0.79922665
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.79825979
107* KDM2B_26808549_Chip-Seq_JURKAT_Human0.79554043
108* KDM2B_26808549_Chip-Seq_DND41_Human0.77902665
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77640102
110OCT4_19829295_ChIP-Seq_ESCs_Human0.77519530
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76934774
112KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.75462501
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75086002
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74739114
115ELK4_26923725_Chip-Seq_MESODERM_Mouse0.74344516
116SOX9_26525672_Chip-Seq_HEART_Mouse0.74146812

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.51286575
2MP0003880_abnormal_central_pattern4.14261793
3MP0004270_analgesia4.13298250
4MP0003635_abnormal_synaptic_transmissio4.01910496
5MP0001968_abnormal_touch/_nociception3.39931007
6MP0002063_abnormal_learning/memory/cond3.18484305
7MP0009745_abnormal_behavioral_response3.06234448
8MP0005423_abnormal_somatic_nervous3.04732564
9MP0002735_abnormal_chemical_nociception2.99921576
10MP0002734_abnormal_mechanical_nocicepti2.97865851
11MP0009046_muscle_twitch2.91800816
12MP0002064_seizures2.88285468
13MP0004858_abnormal_nervous_system2.68547317
14MP0002736_abnormal_nociception_after2.57101330
15MP0002733_abnormal_thermal_nociception2.51111936
16MP0002572_abnormal_emotion/affect_behav2.50062339
17MP0002272_abnormal_nervous_system2.44872252
18MP0001486_abnormal_startle_reflex2.26748865
19MP0001970_abnormal_pain_threshold2.26481261
20MP0002822_catalepsy2.18269981
21MP0006276_abnormal_autonomic_nervous2.17363436
22MP0002184_abnormal_innervation2.15050254
23MP0000778_abnormal_nervous_system2.03882026
24* MP0004811_abnormal_neuron_physiology2.01388067
25MP0002067_abnormal_sensory_capabilities1.97733692
26MP0001440_abnormal_grooming_behavior1.96260039
27MP0001188_hyperpigmentation1.95829163
28MP0002909_abnormal_adrenal_gland1.92958482
29MP0008569_lethality_at_weaning1.92774702
30MP0009780_abnormal_chondrocyte_physiolo1.88923742
31MP0001501_abnormal_sleep_pattern1.85287711
32* MP0000955_abnormal_spinal_cord1.76984334
33MP0002557_abnormal_social/conspecific_i1.69897874
34MP0003121_genomic_imprinting1.69440541
35MP0004924_abnormal_behavior1.66038449
36MP0005386_behavior/neurological_phenoty1.66038449
37* MP0002882_abnormal_neuron_morphology1.53701362
38MP0001984_abnormal_olfaction1.52476502
39MP0000751_myopathy1.48361521
40MP0000569_abnormal_digit_pigmentation1.48108593
41MP0004885_abnormal_endolymph1.41804763
42* MP0002066_abnormal_motor_capabilities/c1.40637251
43MP0002653_abnormal_ependyma_morphology1.39913564
44MP0003879_abnormal_hair_cell1.37753472
45* MP0003329_amyloid_beta_deposits1.32656181
46MP0003633_abnormal_nervous_system1.30391554
47MP0003122_maternal_imprinting1.25536330
48MP0005645_abnormal_hypothalamus_physiol1.17895592
49MP0001502_abnormal_circadian_rhythm1.17694372
50MP0005646_abnormal_pituitary_gland1.15637434
51MP0004142_abnormal_muscle_tone1.14086564
52* MP0002152_abnormal_brain_morphology1.13031073
53MP0003283_abnormal_digestive_organ1.12641983
54MP0003787_abnormal_imprinting1.11480118
55MP0004145_abnormal_muscle_electrophysio1.10335105
56MP0001986_abnormal_taste_sensitivity1.09825597
57MP0003123_paternal_imprinting1.09455115
58MP0008961_abnormal_basal_metabolism1.07478910
59MP0008877_abnormal_DNA_methylation1.03568631
60* MP0003631_nervous_system_phenotype1.01105690
61MP0003634_abnormal_glial_cell0.99001129
62* MP0002229_neurodegeneration0.96105844
63MP0001299_abnormal_eye_distance/0.93752600
64MP0005623_abnormal_meninges_morphology0.93311173
65MP0001348_abnormal_lacrimal_gland0.90140421
66MP0001905_abnormal_dopamine_level0.89885599
67MP0002069_abnormal_eating/drinking_beha0.89411761
68MP0000013_abnormal_adipose_tissue0.87570716
69MP0004085_abnormal_heartbeat0.87563214
70MP0002752_abnormal_somatic_nervous0.86374975
71MP0004233_abnormal_muscle_weight0.84657097
72MP0001529_abnormal_vocalization0.84196046
73MP0002102_abnormal_ear_morphology0.82153388
74MP0008872_abnormal_physiological_respon0.80919017
75MP0003137_abnormal_impulse_conducting0.80509640
76MP0005394_taste/olfaction_phenotype0.80484356
77MP0005499_abnormal_olfactory_system0.80484356
78MP0005551_abnormal_eye_electrophysiolog0.79983633
79MP0001177_atelectasis0.78127310
80MP0008874_decreased_physiological_sensi0.77855030
81MP0004215_abnormal_myocardial_fiber0.77587237
82MP0004133_heterotaxia0.77405091
83MP0004742_abnormal_vestibular_system0.75768938
84MP0010386_abnormal_urinary_bladder0.75420583
85MP0002837_dystrophic_cardiac_calcinosis0.73050070
86MP0000920_abnormal_myelination0.72438434
87MP0003075_altered_response_to0.70723123
88MP0002090_abnormal_vision0.70218874
89MP0005187_abnormal_penis_morphology0.69869055
90MP0003861_abnormal_nervous_system0.69521541
91MP0000747_muscle_weakness0.68404590
92MP0008789_abnormal_olfactory_epithelium0.68267207
93MP0000026_abnormal_inner_ear0.67868507
94MP0002751_abnormal_autonomic_nervous0.67043169
95MP0005535_abnormal_body_temperature0.66505033
96MP0002081_perinatal_lethality0.66029282
97MP0010770_preweaning_lethality0.65665179
98MP0002082_postnatal_lethality0.65665179
99MP0000534_abnormal_ureter_morphology0.65456433
100MP0003172_abnormal_lysosome_physiology0.65382307
101MP0000631_abnormal_neuroendocrine_gland0.64963071
102MP0001963_abnormal_hearing_physiology0.64730155
103MP0003938_abnormal_ear_development0.62689709
104MP0003690_abnormal_glial_cell0.62634269
105MP0010768_mortality/aging0.62528688
106MP0004510_myositis0.62456270
107* MP0003632_abnormal_nervous_system0.59606094
108MP0004130_abnormal_muscle_cell0.59597216
109MP0001943_abnormal_respiration0.59304486
110MP0002638_abnormal_pupillary_reflex0.59259591
111MP0005409_darkened_coat_color0.57242600
112MP0010769_abnormal_survival0.56791095
113MP0004484_altered_response_of0.56624976
114MP0010234_abnormal_vibrissa_follicle0.56307314
115MP0002089_abnormal_postnatal_growth/wei0.55782086
116MP0005167_abnormal_blood-brain_barrier0.55515085
117MP0003183_abnormal_peptide_metabolism0.53749430
118MP0003948_abnormal_gas_homeostasis0.52349232
119MP0000049_abnormal_middle_ear0.49017513

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.91038843
2Focal motor seizures (HP:0011153)5.71340413
3Focal seizures (HP:0007359)5.04529584
4Visual hallucinations (HP:0002367)4.91333526
5Action tremor (HP:0002345)4.43587358
6Supranuclear gaze palsy (HP:0000605)4.21994066
7Progressive cerebellar ataxia (HP:0002073)3.99490966
8Ankle clonus (HP:0011448)3.98793005
9Epileptic encephalopathy (HP:0200134)3.75160568
10Atonic seizures (HP:0010819)3.69644067
11Febrile seizures (HP:0002373)3.58475389
12Absence seizures (HP:0002121)3.39670872
13Mutism (HP:0002300)3.38458916
14Depression (HP:0000716)3.24334233
15Generalized tonic-clonic seizures (HP:0002069)3.19579151
16Abnormality of the lower motor neuron (HP:0002366)3.10737179
17Papilledema (HP:0001085)3.09474134
18Urinary bladder sphincter dysfunction (HP:0002839)3.06405630
19Urinary urgency (HP:0000012)3.05793167
20Insidious onset (HP:0003587)3.05452803
21Termporal pattern (HP:0011008)3.05452803
22Impaired vibration sensation in the lower limbs (HP:0002166)3.04877765
23Cortical dysplasia (HP:0002539)3.03595992
24Dialeptic seizures (HP:0011146)3.00786973
25Poor eye contact (HP:0000817)2.96891100
26Truncal ataxia (HP:0002078)2.88446169
27Abnormal eating behavior (HP:0100738)2.83045475
28Broad-based gait (HP:0002136)2.75238410
29Sleep apnea (HP:0010535)2.75154258
30Impaired social interactions (HP:0000735)2.74810049
31Abnormal social behavior (HP:0012433)2.74810049
32Insomnia (HP:0100785)2.74011864
33Ventricular fibrillation (HP:0001663)2.73412758
34Postural instability (HP:0002172)2.72577640
35Pheochromocytoma (HP:0002666)2.69119259
36Torticollis (HP:0000473)2.68866200
37Spastic gait (HP:0002064)2.68624527
38Dysdiadochokinesis (HP:0002075)2.68610269
39Peripheral hypomyelination (HP:0007182)2.64578174
40Amblyopia (HP:0000646)2.63800222
41Anxiety (HP:0000739)2.63347078
42Genetic anticipation (HP:0003743)2.61306627
43Gaze-evoked nystagmus (HP:0000640)2.60745956
44Dysmetria (HP:0001310)2.59607061
45Gait imbalance (HP:0002141)2.56280869
46Limb dystonia (HP:0002451)2.55670975
47Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.54687254
48Degeneration of the lateral corticospinal tracts (HP:0002314)2.54687254
49Morphological abnormality of the pyramidal tract (HP:0002062)2.53954679
50Abnormality of the corticospinal tract (HP:0002492)2.47340134
51Spastic tetraplegia (HP:0002510)2.45859439
52Hand muscle atrophy (HP:0009130)2.44898471
53Megalencephaly (HP:0001355)2.43670886
54Pointed chin (HP:0000307)2.43468264
55Progressive inability to walk (HP:0002505)2.43017457
56Ulnar claw (HP:0001178)2.40906208
57Focal dystonia (HP:0004373)2.38788393
58Lower limb muscle weakness (HP:0007340)2.38433597
59Hyperventilation (HP:0002883)2.36268539
60Hemiplegia (HP:0002301)2.35107128
61Cerebral inclusion bodies (HP:0100314)2.34417575
62Hemiparesis (HP:0001269)2.33392710
63Neurofibrillary tangles (HP:0002185)2.33260939
64Lissencephaly (HP:0001339)2.32509485
65Impaired smooth pursuit (HP:0007772)2.30138807
66Fetal akinesia sequence (HP:0001989)2.28005786
67Absent speech (HP:0001344)2.27215020
68Bradykinesia (HP:0002067)2.26224205
69Status epilepticus (HP:0002133)2.26190355
70Neuroendocrine neoplasm (HP:0100634)2.25991605
71Agitation (HP:0000713)2.25279242
72Drooling (HP:0002307)2.25037808
73Excessive salivation (HP:0003781)2.25037808
74Amyotrophic lateral sclerosis (HP:0007354)2.24762174
75Scanning speech (HP:0002168)2.24534151
76Failure to thrive in infancy (HP:0001531)2.24432583
77Intention tremor (HP:0002080)2.22824386
78Annular pancreas (HP:0001734)2.21199656
79Retinal dysplasia (HP:0007973)2.19831682
80Craniofacial dystonia (HP:0012179)2.19824273
81Specific learning disability (HP:0001328)2.19677224
82Hypoplasia of the corpus callosum (HP:0002079)2.19209775
83Apathy (HP:0000741)2.16220710
84Bundle branch block (HP:0011710)2.14103596
85Pachygyria (HP:0001302)2.13909850
86Stereotypic behavior (HP:0000733)2.12968104
87Hypoventilation (HP:0002791)2.12638699
88Polyphagia (HP:0002591)2.12577593
89Rapidly progressive (HP:0003678)2.08577749
90Hypoplasia of the brainstem (HP:0002365)2.08280919
91Aplasia/Hypoplasia of the brainstem (HP:0007362)2.08280919
92Hammertoe (HP:0001765)2.06115494
93Hypercortisolism (HP:0001578)2.05193670
94Abnormality of binocular vision (HP:0011514)2.05192433
95Diplopia (HP:0000651)2.05192433
96Upper limb amyotrophy (HP:0009129)2.04008312
97Distal upper limb amyotrophy (HP:0007149)2.04008312
98Abnormality of ocular smooth pursuit (HP:0000617)2.03811482
99Hyperacusis (HP:0010780)2.03662220
100Dysmetric saccades (HP:0000641)2.02317287
101Paraplegia (HP:0010550)2.02021061
102Clonus (HP:0002169)2.01862425
103Cerebral hypomyelination (HP:0006808)2.01787338
104EEG with generalized epileptiform discharges (HP:0011198)2.00100742
105Lower limb amyotrophy (HP:0007210)1.99518535
106Epileptiform EEG discharges (HP:0011182)1.98538774
107Abnormality of pain sensation (HP:0010832)1.98531345
108Impaired pain sensation (HP:0007328)1.98531345
109Neoplasm of the peripheral nervous system (HP:0100007)1.97188697
110Akinesia (HP:0002304)1.95174958
111Hypsarrhythmia (HP:0002521)1.94483843
112Aqueductal stenosis (HP:0002410)1.93243316
113Diminished motivation (HP:0000745)1.92963137
114Lower limb asymmetry (HP:0100559)1.89614130
115Spastic paraplegia (HP:0001258)1.88970820
116Impaired vibratory sensation (HP:0002495)1.88685773
117Esotropia (HP:0000565)1.87974150
118Abnormality of salivation (HP:0100755)1.87917077
119Neuronal loss in central nervous system (HP:0002529)1.86260215
120Abnormal EKG (HP:0003115)1.85670406
121Exotropia (HP:0000577)1.82973813
122Poor suck (HP:0002033)1.82563886
123Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.81563929
124Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.79955289
125Myotonia (HP:0002486)1.79342213
126Obstructive sleep apnea (HP:0002870)1.78557714

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.25344690
2NTRK34.01497126
3MARK13.97260775
4MINK13.23525194
5EPHA42.93058723
6MAP3K42.68582188
7PAK62.62718539
8KSR22.52793512
9NTRK12.39314501
10DAPK22.38184093
11BCR2.23693896
12CAMKK12.02199082
13NTRK22.00467989
14MAP2K72.00054782
15PRKD31.92413943
16KSR11.84759328
17MAP2K41.75776408
18LATS21.72594149
19LMTK21.70075050
20PHKG11.69459607
21PHKG21.69459607
22MAP3K121.64777480
23CDK51.56730428
24STK381.38415751
25SIK21.38293323
26MAP3K21.36444323
27MAPK131.34106618
28UHMK11.29828440
29RET1.26819845
30GRK51.25052497
31DAPK11.21557286
32TAOK11.20114840
33ARAF1.18926568
34TYRO31.18087509
35RIPK41.17997862
36CSNK1A1L1.15778911
37CSNK1G31.13286727
38DYRK1B1.10048586
39CAMKK21.08728436
40PRKCG1.08093027
41CDK141.02707822
42CDK181.02410573
43PLK21.01755705
44CDK150.99917726
45MAP4K20.98212189
46LIMK10.96194923
47PAK30.95858016
48EPHA30.95076854
49CDK190.94130772
50NEK10.93583903
51SCYL20.93168543
52MAP3K60.92752812
53TRIM280.92522161
54RIPK10.91383589
55ALK0.91360432
56CDK11A0.87681898
57PRKCH0.87207680
58FES0.85682316
59TNIK0.85060721
60SGK2230.83440735
61SGK4940.83440735
62PRPF4B0.83373133
63STK110.83189739
64PNCK0.82547329
65MAP3K110.81812034
66TESK10.79934077
67PKN10.78854784
68CSNK1G20.77491089
69MARK20.76933237
70WNK30.75826867
71CAMK10.75668403
72CSNK1G10.74535020
73CAMK2A0.72767822
74MAP3K130.70529192
75PINK10.69470420
76RAF10.69038845
77TRIB30.66512045
78CASK0.66069715
79CAMK2G0.64828164
80MAP3K10.64593627
81FER0.63114613
82RPS6KA20.62446405
83DYRK1A0.62192735
84WNK10.60301902
85PRKCZ0.59764667
86CDC42BPA0.57546452
87MAP2K10.56357263
88SGK30.56331009
89CAMK1G0.55344700
90PDK10.54887293
91PDPK10.53278929
92EPHB20.52315173
93SGK10.51049470
94SGK20.50938230
95PTK2B0.49163607
96ERBB30.48661855
97FYN0.46839507
98DYRK30.46314466
99RPS6KA30.45648851
100ICK0.45563056
101CAMK2B0.45473152
102MAPK120.44762386
103MAPK100.44534020
104PDGFRA0.42082802
105BRSK10.41909974
106DAPK30.41601945
107ROCK20.41446847
108ROCK10.40881602
109MAP3K70.40649580
110CAMK1D0.40498594
111SIK30.40194840
112DYRK20.39735540
113TNK20.38031222
114CSNK1D0.38012793
115PRKCE0.37902339
116OXSR10.37200022
117CAMK40.36195359
118MAPK80.35570105
119DMPK0.35344604
120DDR20.35131132
121CAMK2D0.35002782
122ERBB20.34275892
123MAPK90.33025118
124PRKACA0.32832585
125CSNK1E0.32065086
126PKN20.29629604
127MAP3K50.29378764
128* PRKAA10.28755105
129GSK3B0.27342737

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.32388649
2Nicotine addiction_Homo sapiens_hsa050332.96574476
3Olfactory transduction_Homo sapiens_hsa047402.67636693
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.57698156
5Circadian entrainment_Homo sapiens_hsa047132.45386929
6GABAergic synapse_Homo sapiens_hsa047272.40646925
7Long-term potentiation_Homo sapiens_hsa047202.35146928
8Glutamatergic synapse_Homo sapiens_hsa047242.26053726
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.25564692
10Morphine addiction_Homo sapiens_hsa050322.14406791
11Dopaminergic synapse_Homo sapiens_hsa047282.08602940
12Amphetamine addiction_Homo sapiens_hsa050312.03202270
13Salivary secretion_Homo sapiens_hsa049701.94495708
14Cholinergic synapse_Homo sapiens_hsa047251.93910249
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.92928165
16Insulin secretion_Homo sapiens_hsa049111.92164595
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.81676852
18Gastric acid secretion_Homo sapiens_hsa049711.81012922
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73455518
20Oxytocin signaling pathway_Homo sapiens_hsa049211.60615360
21Taste transduction_Homo sapiens_hsa047421.55722655
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51875663
23Long-term depression_Homo sapiens_hsa047301.50305675
24GnRH signaling pathway_Homo sapiens_hsa049121.49882313
25Renin secretion_Homo sapiens_hsa049241.49049052
26Gap junction_Homo sapiens_hsa045401.47651127
27Cocaine addiction_Homo sapiens_hsa050301.46517876
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42176199
29Serotonergic synapse_Homo sapiens_hsa047261.39277316
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.37542789
31Calcium signaling pathway_Homo sapiens_hsa040201.32442493
32Glioma_Homo sapiens_hsa052141.31669054
33Axon guidance_Homo sapiens_hsa043601.27835847
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27596903
35Type II diabetes mellitus_Homo sapiens_hsa049301.25644617
36Estrogen signaling pathway_Homo sapiens_hsa049151.25372314
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19460311
38cAMP signaling pathway_Homo sapiens_hsa040241.15890072
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12638590
40ErbB signaling pathway_Homo sapiens_hsa040121.12439504
41Melanogenesis_Homo sapiens_hsa049161.06165628
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.02423220
43Collecting duct acid secretion_Homo sapiens_hsa049661.00430997
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00232847
45Oocyte meiosis_Homo sapiens_hsa041141.00117604
46Neurotrophin signaling pathway_Homo sapiens_hsa047220.99389004
47Dorso-ventral axis formation_Homo sapiens_hsa043200.99230858
48Cardiac muscle contraction_Homo sapiens_hsa042600.96584790
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.96306986
50Dilated cardiomyopathy_Homo sapiens_hsa054140.90938118
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89954069
52VEGF signaling pathway_Homo sapiens_hsa043700.87618153
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.85017424
54Endometrial cancer_Homo sapiens_hsa052130.83749544
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83511081
56Nitrogen metabolism_Homo sapiens_hsa009100.82911495
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78883947
58mTOR signaling pathway_Homo sapiens_hsa041500.77632447
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77578983
60Vibrio cholerae infection_Homo sapiens_hsa051100.77239279
61Pancreatic secretion_Homo sapiens_hsa049720.76879012
62Phototransduction_Homo sapiens_hsa047440.76719648
63Choline metabolism in cancer_Homo sapiens_hsa052310.76055972
64Thyroid hormone synthesis_Homo sapiens_hsa049180.74575521
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74285902
66MAPK signaling pathway_Homo sapiens_hsa040100.74142501
67Endocytosis_Homo sapiens_hsa041440.72031408
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69066572
69Insulin signaling pathway_Homo sapiens_hsa049100.66789602
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65835982
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.65009680
72Rap1 signaling pathway_Homo sapiens_hsa040150.63672430
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62007642
74Non-small cell lung cancer_Homo sapiens_hsa052230.61309886
75Hippo signaling pathway_Homo sapiens_hsa043900.60899456
76AMPK signaling pathway_Homo sapiens_hsa041520.60720070
77Renal cell carcinoma_Homo sapiens_hsa052110.60358606
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59863433
79Ras signaling pathway_Homo sapiens_hsa040140.59840471
80Glucagon signaling pathway_Homo sapiens_hsa049220.59577550
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57817545
82Alcoholism_Homo sapiens_hsa050340.57402187
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56183464
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55733578
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55325656
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54196147
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.53892570
88Colorectal cancer_Homo sapiens_hsa052100.53363251
89Bile secretion_Homo sapiens_hsa049760.53220486
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52143472
91Regulation of autophagy_Homo sapiens_hsa041400.51700242
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51604080
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51241376
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50502081
95Prion diseases_Homo sapiens_hsa050200.49104769
96Inositol phosphate metabolism_Homo sapiens_hsa005620.47093754
97Wnt signaling pathway_Homo sapiens_hsa043100.44541809
98Prolactin signaling pathway_Homo sapiens_hsa049170.43840029
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41837453
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41714125
101Circadian rhythm_Homo sapiens_hsa047100.39227646
102Chemokine signaling pathway_Homo sapiens_hsa040620.38965092
103Phagosome_Homo sapiens_hsa041450.36360864
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36057522
105Hedgehog signaling pathway_Homo sapiens_hsa043400.35430325
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33595999
107Ovarian steroidogenesis_Homo sapiens_hsa049130.33023791
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33018390
109Tight junction_Homo sapiens_hsa045300.32313290
110Platelet activation_Homo sapiens_hsa046110.32195910
111Steroid biosynthesis_Homo sapiens_hsa001000.31148723
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29857216

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »