KLC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a light chain of kinesin, a molecular motor responsible for moving vesicles and organelles along microtubules. Defects in this gene are a cause of spastic paraplegia, optic atrophy, and neuropathy (SPOAN) syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.50011304
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.02470736
3locomotory exploration behavior (GO:0035641)5.88049076
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.53995165
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.13474075
6glutamate secretion (GO:0014047)5.09937653
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.07763568
8synaptic vesicle exocytosis (GO:0016079)4.94590886
9regulation of synaptic vesicle exocytosis (GO:2000300)4.88269052
10vocalization behavior (GO:0071625)4.82523971
11sodium ion export (GO:0071436)4.77436928
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.61475661
13cerebellar granule cell differentiation (GO:0021707)4.48001968
14layer formation in cerebral cortex (GO:0021819)4.46899550
15cellular potassium ion homeostasis (GO:0030007)4.44293611
16neurotransmitter secretion (GO:0007269)4.43619642
17regulation of synapse structural plasticity (GO:0051823)4.38663115
18regulation of synaptic vesicle transport (GO:1902803)4.38394233
19cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.36788639
20regulation of glutamate receptor signaling pathway (GO:1900449)4.36780556
21neuronal action potential propagation (GO:0019227)4.34054416
22exploration behavior (GO:0035640)4.23427679
23regulation of neuronal synaptic plasticity (GO:0048168)4.22037968
24cell communication by electrical coupling (GO:0010644)4.14584024
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.09286342
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.04750361
27activation of protein kinase A activity (GO:0034199)3.94442560
28proline transport (GO:0015824)3.92690107
29gamma-aminobutyric acid transport (GO:0015812)3.90805874
30protein localization to synapse (GO:0035418)3.90511411
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.86839154
32dendritic spine morphogenesis (GO:0060997)3.81692941
33glycine transport (GO:0015816)3.80208944
34regulation of synapse maturation (GO:0090128)3.78250382
35amino acid import (GO:0043090)3.76274415
36positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.75806749
37neuromuscular process controlling balance (GO:0050885)3.68272317
38cerebellar Purkinje cell differentiation (GO:0021702)3.61923823
39neuromuscular process controlling posture (GO:0050884)3.61150959
40regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.61085197
41potassium ion import (GO:0010107)3.58153459
42long-term memory (GO:0007616)3.47983096
43synaptic transmission, glutamatergic (GO:0035249)3.47845646
44neurotransmitter transport (GO:0006836)3.47599578
45regulation of ARF protein signal transduction (GO:0032012)3.47226320
46membrane depolarization during action potential (GO:0086010)3.40839631
47neurotransmitter-gated ion channel clustering (GO:0072578)3.38984421
48positive regulation of synapse maturation (GO:0090129)3.35106494
49positive regulation of membrane potential (GO:0045838)3.30573482
50protein retention in ER lumen (GO:0006621)3.30559089
51positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.27699509
52glutamate receptor signaling pathway (GO:0007215)3.25921485
53regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.25841851
54regulation of excitatory postsynaptic membrane potential (GO:0060079)3.23719240
55neuron-neuron synaptic transmission (GO:0007270)3.21532679
56regulation of neurotransmitter levels (GO:0001505)3.21306416
57cell communication involved in cardiac conduction (GO:0086065)3.20711590
58regulation of synaptic plasticity (GO:0048167)3.20476001
59synaptic vesicle endocytosis (GO:0048488)3.18247172
60cellular sodium ion homeostasis (GO:0006883)3.16836665
61neuron cell-cell adhesion (GO:0007158)3.13574401
62potassium ion homeostasis (GO:0055075)3.13540327
63cerebellar Purkinje cell layer development (GO:0021680)3.13344573
64dendrite morphogenesis (GO:0048813)3.12857973
65regulation of neurotransmitter secretion (GO:0046928)3.11442774
66regulation of dendritic spine morphogenesis (GO:0061001)3.10955628
67positive regulation of dendritic spine development (GO:0060999)3.10619594
68negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.09973432
69positive regulation of dendritic spine morphogenesis (GO:0061003)3.09805913
70vesicle transport along microtubule (GO:0047496)3.09443639
71establishment of nucleus localization (GO:0040023)3.09309048
72regulation of postsynaptic membrane potential (GO:0060078)3.08009926
73regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.06745853
74neuronal ion channel clustering (GO:0045161)3.06626824
75maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.06291769
76cytoskeletal anchoring at plasma membrane (GO:0007016)3.04561895
77positive regulation of potassium ion transmembrane transport (GO:1901381)3.04218446
78mating behavior (GO:0007617)3.03391104
79establishment of mitochondrion localization (GO:0051654)3.03324839
80activation of Rac GTPase activity (GO:0032863)3.02965931
81positive regulation of neurotransmitter secretion (GO:0001956)3.01582825
82prepulse inhibition (GO:0060134)3.00844029
83auditory behavior (GO:0031223)3.00578007
84retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.98580870
85negative regulation of dendrite morphogenesis (GO:0050774)2.98344028
86response to auditory stimulus (GO:0010996)2.97696146
87regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.97005223
88adherens junction assembly (GO:0034333)2.95306934
89membrane repolarization (GO:0086009)2.94801136
90postsynaptic membrane organization (GO:0001941)2.94185151
91negative regulation of synaptic transmission, GABAergic (GO:0032229)2.93475504
92neuromuscular process (GO:0050905)2.93204953
93L-amino acid import (GO:0043092)2.91333532
94positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.90523040
95cell migration in hindbrain (GO:0021535)2.89231682
96membrane depolarization (GO:0051899)2.88134990
97regulation of clathrin-mediated endocytosis (GO:2000369)2.87511704
98positive regulation of synaptic transmission, GABAergic (GO:0032230)2.87068400
99mitochondrion transport along microtubule (GO:0047497)2.87046556
100establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.87046556
101transmission of nerve impulse (GO:0019226)2.86329031
102regulation of neurotransmitter transport (GO:0051588)2.86108657
103negative regulation of microtubule polymerization (GO:0031115)2.85226801
104G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.84458482
105peptidyl-tyrosine autophosphorylation (GO:0038083)2.84210447
106chemosensory behavior (GO:0007635)2.83924944
107negative regulation of cell size (GO:0045792)2.83790849
108cell-substrate adherens junction assembly (GO:0007045)2.82354872
109focal adhesion assembly (GO:0048041)2.82354872
110regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.81490039
111regulation of membrane repolarization (GO:0060306)2.80628164
112regulation of mammary gland epithelial cell proliferation (GO:0033599)2.80228491
113neuron recognition (GO:0008038)2.79690359
114plasma membrane repair (GO:0001778)2.79649360
115membrane hyperpolarization (GO:0060081)2.79049642
116dendritic spine organization (GO:0097061)2.77995082
117regulation of vesicle fusion (GO:0031338)2.77913275
118organelle transport along microtubule (GO:0072384)2.77057231
119regulation of voltage-gated calcium channel activity (GO:1901385)2.76979126
120protein localization to endosome (GO:0036010)2.75760638
121membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.75430479
122positive regulation of neurotransmitter transport (GO:0051590)2.74768830
123dopamine receptor signaling pathway (GO:0007212)2.74728878
124regulation of synaptic transmission, glutamatergic (GO:0051966)2.72967211
125positive regulation of potassium ion transport (GO:0043268)2.72492332
126protein targeting to plasma membrane (GO:0072661)2.72001542
127axonal fasciculation (GO:0007413)2.71970372
128dicarboxylic acid transport (GO:0006835)2.71609470
129regulation of NFAT protein import into nucleus (GO:0051532)2.68357681
130positive regulation of dendrite development (GO:1900006)2.67805727
131semaphorin-plexin signaling pathway (GO:0071526)2.63958090
132regulation of early endosome to late endosome transport (GO:2000641)2.62611964
133COPI coating of Golgi vesicle (GO:0048205)2.60124891
134Golgi transport vesicle coating (GO:0048200)2.60124891
135vesicle docking involved in exocytosis (GO:0006904)2.57098386
136central nervous system myelination (GO:0022010)2.54889730
137axon ensheathment in central nervous system (GO:0032291)2.54889730

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.46403810
2DROSHA_22980978_ChIP-Seq_HELA_Human2.86923639
3RARB_27405468_Chip-Seq_BRAIN_Mouse2.83028696
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.77330480
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76055472
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73002436
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.65399582
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.63641511
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62096695
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62096695
11REST_21632747_ChIP-Seq_MESCs_Mouse2.59882683
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.47619901
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45087184
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43456389
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41595142
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.39892614
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.25789131
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21446627
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.20497746
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20004471
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.19797267
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.17132018
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14660778
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.10028747
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.09220053
26RACK7_27058665_Chip-Seq_MCF-7_Human2.03699071
27RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03292873
28GBX2_23144817_ChIP-Seq_PC3_Human1.99587820
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91068552
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84739690
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.84339661
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.83766767
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.82436994
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.78413342
35KDM2B_26808549_Chip-Seq_K562_Human1.77914026
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74308997
37* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.73979390
38P68_20966046_ChIP-Seq_HELA_Human1.73325860
39TET1_21451524_ChIP-Seq_MESCs_Mouse1.72090443
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70423617
41UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.66230321
42SRY_22984422_ChIP-ChIP_TESTIS_Rat1.65727692
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65041688
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.63088115
45* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.59902339
46* TCF7_22412390_ChIP-Seq_EML_Mouse1.55346953
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51244284
48ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.51090328
49* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.49899737
50MYC_22102868_ChIP-Seq_BL_Human1.49450578
51* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48444573
52* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.47237324
53VDR_21846776_ChIP-Seq_THP-1_Human1.43551559
54CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.40670565
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40417874
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.39533864
57* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38036500
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.37923372
59AR_21572438_ChIP-Seq_LNCaP_Human1.37654103
60SA1_27219007_Chip-Seq_ERYTHROID_Human1.37494495
61SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36617467
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33791297
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33737343
64CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32748625
65* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32338727
66ZNF274_21170338_ChIP-Seq_K562_Hela1.30934286
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30727822
68* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28958501
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27805625
70MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.27135501
71* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27075701
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25225697
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25180987
74AR_19668381_ChIP-Seq_PC3_Human1.23252953
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22367125
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22318463
77SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.21574896
78CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19765068
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18887722
80* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18669837
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17166414
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16587703
83LXR_22292898_ChIP-Seq_THP-1_Human1.16303443
84SOX2_21211035_ChIP-Seq_LN229_Gbm1.15797594
85CTCF_27219007_Chip-Seq_Bcells_Human1.15175450
86DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15044838
87NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14736269
88SMAD4_21799915_ChIP-Seq_A2780_Human1.14228610
89TP53_22127205_ChIP-Seq_IMR90_Human1.14062431
90* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13491286
91* KDM2B_26808549_Chip-Seq_DND41_Human1.13406728
92RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12552779
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11990269
94RING1B_27294783_Chip-Seq_NPCs_Mouse1.11517802
95* TET1_21490601_ChIP-Seq_MESCs_Mouse1.10900073
96CLOCK_20551151_ChIP-Seq_293T_Human1.08577854
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04224814
98SMC4_20622854_ChIP-Seq_HELA_Human1.03698845
99TP53_23651856_ChIP-Seq_MEFs_Mouse1.03566953
100TP53_20018659_ChIP-ChIP_R1E_Mouse1.03256679
101ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02630557
102KDM2B_26808549_Chip-Seq_JURKAT_Human1.02531426
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00432598
104ELF1_20517297_ChIP-Seq_JURKAT_Human1.00407086
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00349795
106KLF4_19829295_ChIP-Seq_ESCs_Human0.98570615
107ESR2_21235772_ChIP-Seq_MCF-7_Human0.98433517
108KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97829624
109TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.96683489
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96190661
111CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95850863
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.95276329
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94382693
114ESR1_20079471_ChIP-ChIP_T-47D_Human0.93047614
115ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92485037
116PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91844799
117STAT3_23295773_ChIP-Seq_U87_Human0.91469659
118SMAD3_21741376_ChIP-Seq_ESCs_Human0.91158481
119YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90716381
120EP300_21415370_ChIP-Seq_HL-1_Mouse0.90484904
121EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90468754
122OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89746379
123OCT4_19829295_ChIP-Seq_ESCs_Human0.89605614
124SMAD3_21741376_ChIP-Seq_HESCs_Human0.89241370
125RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88991294
126CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88547569
127P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87739962
128AHR_22903824_ChIP-Seq_MCF-7_Human0.86281985
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85936837
130CREB1_26743006_Chip-Seq_LNCaP_Human0.85928792
131SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83979398
132PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83478492
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.83418756
134CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83139503
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82864663
136AR_25329375_ChIP-Seq_VCAP_Human0.81804501
137BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80850516
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.80071470
139RXR_22108803_ChIP-Seq_LS180_Human0.79187147
140ZNF263_19887448_ChIP-Seq_K562_Human0.79166918
141TCF4_23295773_ChIP-Seq_U87_Human0.77076040

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.79844023
2MP0003635_abnormal_synaptic_transmissio4.00269309
3MP0003880_abnormal_central_pattern3.83715262
4MP0004270_analgesia3.73102317
5MP0002063_abnormal_learning/memory/cond3.07200489
6MP0009046_muscle_twitch3.02262644
7MP0009745_abnormal_behavioral_response3.01071114
8MP0005423_abnormal_somatic_nervous2.94410681
9MP0002064_seizures2.90057277
10MP0001968_abnormal_touch/_nociception2.71610248
11MP0003705_abnormal_hypodermis_morpholog2.61756914
12MP0002734_abnormal_mechanical_nocicepti2.51338848
13MP0002272_abnormal_nervous_system2.41222808
14MP0002572_abnormal_emotion/affect_behav2.39667863
15MP0002822_catalepsy2.36699612
16MP0004858_abnormal_nervous_system2.35916415
17MP0009780_abnormal_chondrocyte_physiolo2.29895615
18MP0001486_abnormal_startle_reflex2.25329050
19MP0008569_lethality_at_weaning2.19652418
20MP0001348_abnormal_lacrimal_gland2.18043650
21MP0002909_abnormal_adrenal_gland2.16247945
22MP0000751_myopathy2.10952796
23MP0003329_amyloid_beta_deposits2.04857980
24MP0002736_abnormal_nociception_after1.97279025
25MP0003123_paternal_imprinting1.96885662
26MP0002733_abnormal_thermal_nociception1.96838658
27MP0001501_abnormal_sleep_pattern1.94261683
28MP0002735_abnormal_chemical_nociception1.92122623
29MP0004811_abnormal_neuron_physiology1.90834588
30MP0001440_abnormal_grooming_behavior1.88285734
31MP0001970_abnormal_pain_threshold1.82795749
32MP0002067_abnormal_sensory_capabilities1.76082322
33MP0004145_abnormal_muscle_electrophysio1.71499319
34MP0002184_abnormal_innervation1.63690740
35MP0004885_abnormal_endolymph1.63332590
36MP0000955_abnormal_spinal_cord1.61366606
37MP0003283_abnormal_digestive_organ1.55323576
38MP0001849_ear_inflammation1.53698382
39MP0002249_abnormal_larynx_morphology1.53670244
40MP0003879_abnormal_hair_cell1.52113853
41MP0002557_abnormal_social/conspecific_i1.50395667
42MP0005409_darkened_coat_color1.49805689
43MP0008961_abnormal_basal_metabolism1.49067685
44MP0005386_behavior/neurological_phenoty1.48616528
45MP0004924_abnormal_behavior1.48616528
46MP0002837_dystrophic_cardiac_calcinosis1.48485547
47MP0000537_abnormal_urethra_morphology1.47922917
48MP0001346_abnormal_lacrimal_gland1.47828002
49MP0003633_abnormal_nervous_system1.45233009
50MP0000778_abnormal_nervous_system1.45216513
51MP0000579_abnormal_nail_morphology1.40245285
52MP0002066_abnormal_motor_capabilities/c1.38673279
53MP0003646_muscle_fatigue1.36627544
54MP0002882_abnormal_neuron_morphology1.34072489
55MP0000678_abnormal_parathyroid_gland1.28381189
56MP0004215_abnormal_myocardial_fiber1.24413356
57MP0004233_abnormal_muscle_weight1.22420190
58MP0005646_abnormal_pituitary_gland1.21847198
59MP0006276_abnormal_autonomic_nervous1.19764818
60MP0005623_abnormal_meninges_morphology1.19642068
61MP0000569_abnormal_digit_pigmentation1.17765330
62MP0003631_nervous_system_phenotype1.17586245
63MP0000013_abnormal_adipose_tissue1.15631698
64MP0001984_abnormal_olfaction1.15406829
65MP0005076_abnormal_cell_differentiation1.13833600
66MP0003787_abnormal_imprinting1.10271690
67MP0000747_muscle_weakness1.08236071
68MP0005451_abnormal_body_composition1.07131527
69MP0003137_abnormal_impulse_conducting1.06680689
70MP0004130_abnormal_muscle_cell1.05195559
71MP0003075_altered_response_to1.05113395
72MP0005167_abnormal_blood-brain_barrier1.04193154
73MP0002152_abnormal_brain_morphology1.04105934
74MP0004085_abnormal_heartbeat1.04008297
75MP0004142_abnormal_muscle_tone1.02820703
76MP0005645_abnormal_hypothalamus_physiol1.01912836
77MP0004084_abnormal_cardiac_muscle1.00304395
78MP0003122_maternal_imprinting0.98911573
79MP0004036_abnormal_muscle_relaxation0.98634144
80MP0003690_abnormal_glial_cell0.98407455
81MP0001502_abnormal_circadian_rhythm0.98202444
82MP0008260_abnormal_autophagy0.97503009
83MP0009672_abnormal_birth_weight0.93378759
84MP0002229_neurodegeneration0.92454647
85MP0004185_abnormal_adipocyte_glucose0.91994439
86MP0003634_abnormal_glial_cell0.90518208
87MP0008874_decreased_physiological_sensi0.90278510
88MP0003566_abnormal_cell_adhesion0.90164767
89MP0004510_myositis0.89879668
90MP0000566_synostosis0.89272668
91MP0000534_abnormal_ureter_morphology0.88255975
92MP0000604_amyloidosis0.88109222
93MP0004484_altered_response_of0.86379736
94MP0000749_muscle_degeneration0.85787632
95MP0003861_abnormal_nervous_system0.85528812
96MP0002069_abnormal_eating/drinking_beha0.84892168
97MP0004087_abnormal_muscle_fiber0.84530080
98MP0003632_abnormal_nervous_system0.83480465
99MP0000733_abnormal_muscle_development0.83011829
100MP0008872_abnormal_physiological_respon0.82974231
101MP0001299_abnormal_eye_distance/0.82670107
102MP0005535_abnormal_body_temperature0.82595479
103MP0002877_abnormal_melanocyte_morpholog0.82275828
104MP0001188_hyperpigmentation0.79472458
105MP0002269_muscular_atrophy0.78733034
106MP0005620_abnormal_muscle_contractility0.78639959
107MP0001177_atelectasis0.77848166
108MP0004043_abnormal_pH_regulation0.77010498
109MP0000920_abnormal_myelination0.76727032
110MP0003172_abnormal_lysosome_physiology0.73270467
111MP0005375_adipose_tissue_phenotype0.71675641
112MP0001943_abnormal_respiration0.69862488
113MP0001905_abnormal_dopamine_level0.69703594
114MP0002234_abnormal_pharynx_morphology0.69015645
115MP0003385_abnormal_body_wall0.68588195
116MP0005187_abnormal_penis_morphology0.67992385
117MP0010769_abnormal_survival0.67609954
118MP0002089_abnormal_postnatal_growth/wei0.67458575
119MP0003091_abnormal_cell_migration0.67284805
120MP0000759_abnormal_skeletal_muscle0.67067544
121MP0010234_abnormal_vibrissa_follicle0.66773722
122MP0002972_abnormal_cardiac_muscle0.66530500
123MP0003942_abnormal_urinary_system0.66281042
124MP0002106_abnormal_muscle_physiology0.64685171
125MP0000681_abnormal_thyroid_gland0.64640386
126MP0003045_fibrosis0.64174004
127MP0000462_abnormal_digestive_system0.64162882
128MP0002081_perinatal_lethality0.63296355
129MP0010768_mortality/aging0.62980411
130MP0003115_abnormal_respiratory_system0.62760407
131MP0010770_preweaning_lethality0.61458411
132MP0005499_abnormal_olfactory_system0.59493400
133MP0005394_taste/olfaction_phenotype0.59493400
134MP0005410_abnormal_fertilization0.58759846
135MP0000003_abnormal_adipose_tissue0.58451371

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.31327225
2Focal motor seizures (HP:0011153)5.60287919
3Visual hallucinations (HP:0002367)4.94304482
4Focal seizures (HP:0007359)4.80977632
5Action tremor (HP:0002345)4.34234534
6Obstructive sleep apnea (HP:0002870)4.04638717
7Supranuclear gaze palsy (HP:0000605)3.83188510
8Ankle clonus (HP:0011448)3.82914945
9Progressive cerebellar ataxia (HP:0002073)3.78540616
10Abnormality of the lower motor neuron (HP:0002366)3.65065685
11Ventricular fibrillation (HP:0001663)3.57903771
12Atonic seizures (HP:0010819)3.41086790
13Bundle branch block (HP:0011710)3.39746577
14Epileptic encephalopathy (HP:0200134)3.31521521
15Depression (HP:0000716)3.26429810
16Generalized tonic-clonic seizures (HP:0002069)3.21526551
17Febrile seizures (HP:0002373)3.20370451
18Postural instability (HP:0002172)3.18531888
19Absence seizures (HP:0002121)3.17036758
20Impaired vibration sensation in the lower limbs (HP:0002166)3.16640935
21Poor eye contact (HP:0000817)3.03213532
22Urinary bladder sphincter dysfunction (HP:0002839)3.03050236
23Dysdiadochokinesis (HP:0002075)2.97916932
24Urinary urgency (HP:0000012)2.96551183
25Dysmetric saccades (HP:0000641)2.95182514
26Hemiplegia (HP:0002301)2.89470973
27Abnormal social behavior (HP:0012433)2.87652167
28Impaired social interactions (HP:0000735)2.87652167
29Insomnia (HP:0100785)2.86447258
30Papilledema (HP:0001085)2.82582438
31Dialeptic seizures (HP:0011146)2.78548594
32Gaze-evoked nystagmus (HP:0000640)2.77147506
33Dysmetria (HP:0001310)2.74483597
34Genetic anticipation (HP:0003743)2.70346600
35Mutism (HP:0002300)2.67553732
36Annular pancreas (HP:0001734)2.63099942
37Truncal ataxia (HP:0002078)2.61958584
38Anxiety (HP:0000739)2.61773227
39Shallow orbits (HP:0000586)2.61414373
40Exercise-induced myalgia (HP:0003738)2.61196244
41Abnormal eating behavior (HP:0100738)2.59181885
42Intention tremor (HP:0002080)2.57867788
43Impaired smooth pursuit (HP:0007772)2.56748336
44Pointed chin (HP:0000307)2.55797260
45Broad-based gait (HP:0002136)2.54675372
46Torticollis (HP:0000473)2.53694896
47Broad face (HP:0000283)2.50205185
48Cerebral hypomyelination (HP:0006808)2.44573838
49Distal lower limb amyotrophy (HP:0008944)2.43631162
50Spastic gait (HP:0002064)2.43588192
51Termporal pattern (HP:0011008)2.41565401
52Insidious onset (HP:0003587)2.41565401
53Sudden death (HP:0001699)2.40240628
54Hyperacusis (HP:0010780)2.38868450
55Tetraplegia (HP:0002445)2.37283376
56Megalencephaly (HP:0001355)2.36597229
57Ulnar bowing (HP:0003031)2.34895086
58Cerebral aneurysm (HP:0004944)2.33045771
59Bronchomalacia (HP:0002780)2.30846569
60Turricephaly (HP:0000262)2.30515343
61Abnormality of ocular smooth pursuit (HP:0000617)2.30261296
62Pheochromocytoma (HP:0002666)2.28097263
63Hemiparesis (HP:0001269)2.28080440
64Bradykinesia (HP:0002067)2.27888483
65Focal dystonia (HP:0004373)2.25548668
66Apathy (HP:0000741)2.24239044
67Amblyopia (HP:0000646)2.22936892
68Lower limb muscle weakness (HP:0007340)2.21843549
69Abnormal EKG (HP:0003115)2.17653817
70Akinesia (HP:0002304)2.15412798
71Rapidly progressive (HP:0003678)2.15403993
72Difficulty climbing stairs (HP:0003551)2.15287136
73Abnormality of the Achilles tendon (HP:0005109)2.14387259
74Upper limb amyotrophy (HP:0009129)2.13859349
75Distal upper limb amyotrophy (HP:0007149)2.13859349
76Lower limb amyotrophy (HP:0007210)2.12459673
77Long palpebral fissure (HP:0000637)2.12260684
78Scanning speech (HP:0002168)2.11686257
79Difficulty running (HP:0009046)2.11500395
80Resting tremor (HP:0002322)2.11136099
81Clonus (HP:0002169)2.10821316
82Prolonged QT interval (HP:0001657)2.10744310
83Impaired vibratory sensation (HP:0002495)2.10135825
84Overriding aorta (HP:0002623)2.08699655
85Diplopia (HP:0000651)2.07097711
86Abnormality of binocular vision (HP:0011514)2.07097711
87Status epilepticus (HP:0002133)2.05941598
88Cerebral inclusion bodies (HP:0100314)2.05206668
89Fetal akinesia sequence (HP:0001989)2.03764068
90Aplasia involving bones of the upper limbs (HP:0009823)2.03519146
91Aplasia of the phalanges of the hand (HP:0009802)2.03519146
92Aplasia involving bones of the extremities (HP:0009825)2.03519146
93Stridor (HP:0010307)2.03246634
94Elfin facies (HP:0004428)2.02842832
95Craniofacial dystonia (HP:0012179)2.02141225
96Myotonia (HP:0002486)2.02099377
97Stereotypic behavior (HP:0000733)2.02079435
98Heart block (HP:0012722)2.02074239
99Neoplasm of the heart (HP:0100544)1.99466210
100Peripheral hypomyelination (HP:0007182)1.98806732
101Diminished motivation (HP:0000745)1.98576400
102Progressive inability to walk (HP:0002505)1.95927165
103Neurofibrillary tangles (HP:0002185)1.95442485
104Abnormality of saccadic eye movements (HP:0000570)1.94469353
105Distal sensory impairment (HP:0002936)1.93723488
106Hypercortisolism (HP:0001578)1.91476519
107Syncope (HP:0001279)1.91209184
108Amyotrophic lateral sclerosis (HP:0007354)1.90909853
109Hyperparathyroidism (HP:0000843)1.88310595
110Sleep apnea (HP:0010535)1.87597079
111Exercise-induced muscle cramps (HP:0003710)1.87155368
112Lower limb asymmetry (HP:0100559)1.86174027
113Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.86111647
114Neuronal loss in central nervous system (HP:0002529)1.85228634
115Abnormality of the corticospinal tract (HP:0002492)1.84971879
116Foot dorsiflexor weakness (HP:0009027)1.84940379
117Abnormal atrioventricular conduction (HP:0005150)1.84785911
118Ventricular arrhythmia (HP:0004308)1.83422198
119Hand muscle atrophy (HP:0009130)1.83102462
120Neuroendocrine neoplasm (HP:0100634)1.82879503
121Agitation (HP:0000713)1.82241506
122Protrusio acetabuli (HP:0003179)1.81872375
123Premature rupture of membranes (HP:0001788)1.81769998
124Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80480878
125Hyporeflexia of lower limbs (HP:0002600)1.79815178
126Myopathic facies (HP:0002058)1.79539982
127Precocious puberty (HP:0000826)1.79294587
128Spinal canal stenosis (HP:0003416)1.78991046
129Mildly elevated creatine phosphokinase (HP:0008180)1.78791243
130Rigidity (HP:0002063)1.78788655
131Centrally nucleated skeletal muscle fibers (HP:0003687)1.78614057
132Hammertoe (HP:0001765)1.78433528
133Achilles tendon contracture (HP:0001771)1.77454687
134Hypoventilation (HP:0002791)1.73077699
135Delusions (HP:0000746)1.71170396
136Abnormal gallbladder physiology (HP:0012438)1.70981271
137Cholecystitis (HP:0001082)1.70981271
138Renal duplication (HP:0000075)1.70376360
139Deep palmar crease (HP:0006191)1.68870817
140Spinal cord compression (HP:0002176)1.64436867
141Abnormality of the foot musculature (HP:0001436)1.63331319
142Distal lower limb muscle weakness (HP:0009053)1.63011818
143Growth hormone excess (HP:0000845)1.61804440
144Slow progression (HP:0003677)1.60917612

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.95399030
2NTRK33.77298841
3PRKD33.10098749
4EPHA43.09275515
5PAK62.69880953
6MINK12.67135675
7MAP3K42.66483059
8MARK12.59604721
9DAPK22.47211876
10KSR22.38572856
11CAMKK12.31706077
12SMG12.19007001
13SIK12.00913948
14STK381.99502107
15EEF2K1.97650915
16LMTK21.90249650
17NTRK11.89658426
18NTRK21.86317372
19MAP2K41.78143119
20CDK121.74992685
21TESK11.74883606
22PHKG21.74059525
23PHKG11.74059525
24MAP2K71.65165272
25TRIB31.57319059
26RIPK11.56700055
27TYRO31.56341732
28TAOK11.50994582
29LATS21.47944250
30CDK51.43872173
31EPHA21.38894621
32KSR11.38123901
33UHMK11.30891391
34IRAK31.28354733
35NEK11.27765637
36BRAF1.26238948
37MAP3K21.26225062
38PINK11.25069579
39ALK1.23780817
40PRKCH1.17634393
41RET1.15645881
42DAPK11.14573908
43SIK21.13420067
44WNK11.10478355
45RIPK41.07925249
46GRK51.06013084
47CAMK1D1.04965316
48STK111.04665121
49CAMKK21.03690490
50PTK21.02848894
51MAP3K121.02461363
52PRKCG1.01542429
53CDK190.99382623
54PAK30.96319488
55CAMK10.95481381
56MAP3K110.95461745
57PRKD20.92371083
58ICK0.91795810
59PDK30.90279213
60PDK40.90279213
61PKN20.86841329
62SGK30.86514614
63SGK2230.85798761
64SGK4940.85798761
65CDC42BPA0.85713996
66CDK150.84744944
67MTOR0.84262815
68CDK180.83394265
69PDK10.82273956
70PRPF4B0.79788038
71ARAF0.78800076
72IRAK20.78497593
73CAMK1G0.77885065
74DMPK0.77591192
75CDK140.77479121
76ERN10.77401270
77FES0.77088398
78MAP3K70.76739253
79PDPK10.75732157
80PLK20.75333422
81MAPK130.74992353
82PDGFRA0.74068384
83MAP3K10.73691699
84CDK11A0.72955547
85SCYL20.72440267
86PNCK0.72179742
87TAOK20.70659936
88MAP3K130.69793569
89MARK20.68888783
90PTK2B0.67028044
91TESK20.66083200
92CAMK2A0.65936928
93MST1R0.65323093
94FGFR40.64126534
95NEK60.63786573
96PIM20.62314735
97SGK20.60855926
98SGK10.59904497
99BRSK10.58420229
100TNK20.57080456
101CAMK40.55845785
102MAPK120.55688688
103BMX0.52328196
104* RPS6KA30.52232199
105PRKCI0.49810207
106RAF10.49257526
107PAK40.49253692
108MAPK100.48695969
109PAK20.47865498
110PRKCZ0.47715345
111PRKG20.47549277
112DAPK30.47401077
113RPS6KA20.44626385
114FER0.44618445
115TTN0.44313243
116SIK30.44251645
117MAP3K100.44147881
118ROCK10.43726821
119NME20.42751988
120MAP2K10.42274974
121DDR20.42137731
122AKT20.41920886
123FYN0.40906423
124PRKD10.39861385
125MAPK80.38124020
126DYRK1A0.37831800
127CAMK2G0.37734028
128CAMK2B0.37710840
129CAMK2D0.37664838
130ROCK20.36012764
131WNK40.35789725
132DYRK1B0.34213054
133LIMK10.33849305

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.01904405
2Nicotine addiction_Homo sapiens_hsa050332.65493217
3Olfactory transduction_Homo sapiens_hsa047402.56958953
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.53129230
5Circadian entrainment_Homo sapiens_hsa047132.37259428
6Long-term potentiation_Homo sapiens_hsa047202.34697923
7GABAergic synapse_Homo sapiens_hsa047272.26188581
8Glutamatergic synapse_Homo sapiens_hsa047242.18199169
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.05173002
10Amphetamine addiction_Homo sapiens_hsa050312.04229900
11Morphine addiction_Homo sapiens_hsa050322.00381573
12Insulin secretion_Homo sapiens_hsa049112.00071476
13Salivary secretion_Homo sapiens_hsa049701.99325702
14Nitrogen metabolism_Homo sapiens_hsa009101.96927542
15Gastric acid secretion_Homo sapiens_hsa049711.96574135
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.91580609
17Dopaminergic synapse_Homo sapiens_hsa047281.86597520
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.84295199
19Cholinergic synapse_Homo sapiens_hsa047251.73201249
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.66704810
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.65001964
22Oxytocin signaling pathway_Homo sapiens_hsa049211.59981600
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.56356483
24Renin secretion_Homo sapiens_hsa049241.45211555
25Vitamin B6 metabolism_Homo sapiens_hsa007501.45204293
26Type II diabetes mellitus_Homo sapiens_hsa049301.44966871
27GnRH signaling pathway_Homo sapiens_hsa049121.42914783
28Calcium signaling pathway_Homo sapiens_hsa040201.39195307
29Cocaine addiction_Homo sapiens_hsa050301.35057983
30Taste transduction_Homo sapiens_hsa047421.34980849
31Long-term depression_Homo sapiens_hsa047301.34878247
32Gap junction_Homo sapiens_hsa045401.28263948
33Estrogen signaling pathway_Homo sapiens_hsa049151.25104309
34cAMP signaling pathway_Homo sapiens_hsa040241.24165664
35Glioma_Homo sapiens_hsa052141.23158579
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22068256
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20924333
38Dilated cardiomyopathy_Homo sapiens_hsa054141.15102975
39Dorso-ventral axis formation_Homo sapiens_hsa043201.14843282
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11305140
41Cardiac muscle contraction_Homo sapiens_hsa042601.08684944
42Serotonergic synapse_Homo sapiens_hsa047261.06691158
43ErbB signaling pathway_Homo sapiens_hsa040120.99686810
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99156713
45Melanogenesis_Homo sapiens_hsa049160.97887140
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97369339
47Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96272382
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.93278371
49Axon guidance_Homo sapiens_hsa043600.91609126
50Oocyte meiosis_Homo sapiens_hsa041140.90472902
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89873458
52Chronic myeloid leukemia_Homo sapiens_hsa052200.88644426
53mTOR signaling pathway_Homo sapiens_hsa041500.88451783
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.88016454
55Biosynthesis of amino acids_Homo sapiens_hsa012300.86709747
56Glucagon signaling pathway_Homo sapiens_hsa049220.85642328
57Thyroid hormone synthesis_Homo sapiens_hsa049180.85275627
58Pancreatic secretion_Homo sapiens_hsa049720.85185245
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85171693
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.85022959
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84751738
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83177475
63Notch signaling pathway_Homo sapiens_hsa043300.82487240
64VEGF signaling pathway_Homo sapiens_hsa043700.81553088
65Bile secretion_Homo sapiens_hsa049760.79379568
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75178989
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73097753
68Insulin signaling pathway_Homo sapiens_hsa049100.72126723
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71865300
70Hippo signaling pathway_Homo sapiens_hsa043900.71556957
71MAPK signaling pathway_Homo sapiens_hsa040100.70782886
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70058482
73Choline metabolism in cancer_Homo sapiens_hsa052310.69560840
74Endocytosis_Homo sapiens_hsa041440.69413450
75Bladder cancer_Homo sapiens_hsa052190.69321538
76Focal adhesion_Homo sapiens_hsa045100.68885217
77Collecting duct acid secretion_Homo sapiens_hsa049660.68601598
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67829540
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67189587
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65627967
81Thyroid cancer_Homo sapiens_hsa052160.65361815
82Endometrial cancer_Homo sapiens_hsa052130.64145410
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63910389
84Inositol phosphate metabolism_Homo sapiens_hsa005620.60201355
85Proteoglycans in cancer_Homo sapiens_hsa052050.59774273
86Fructose and mannose metabolism_Homo sapiens_hsa000510.59169361
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58583629
88Rap1 signaling pathway_Homo sapiens_hsa040150.58264588
89Arginine and proline metabolism_Homo sapiens_hsa003300.58149071
90Non-small cell lung cancer_Homo sapiens_hsa052230.57597902
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.56441248
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55037051
93Pentose phosphate pathway_Homo sapiens_hsa000300.54996160
94Acute myeloid leukemia_Homo sapiens_hsa052210.51756513
95Adherens junction_Homo sapiens_hsa045200.50561155
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50195907
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.50164820
98Renal cell carcinoma_Homo sapiens_hsa052110.49490983
99Fatty acid biosynthesis_Homo sapiens_hsa000610.48536454
100Ras signaling pathway_Homo sapiens_hsa040140.48437523
101Vibrio cholerae infection_Homo sapiens_hsa051100.46956525
102Alcoholism_Homo sapiens_hsa050340.46492557
103Pancreatic cancer_Homo sapiens_hsa052120.45891519
104Arginine biosynthesis_Homo sapiens_hsa002200.45827113
105Prion diseases_Homo sapiens_hsa050200.44080025
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41191184
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.41003648
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40330516
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39801366
110Insulin resistance_Homo sapiens_hsa049310.39542719
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39185643
112AMPK signaling pathway_Homo sapiens_hsa041520.39007706
113Tight junction_Homo sapiens_hsa045300.38628008
114Circadian rhythm_Homo sapiens_hsa047100.37293414
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37089107
116Phototransduction_Homo sapiens_hsa047440.35887077
117Wnt signaling pathway_Homo sapiens_hsa043100.35678232
118Prolactin signaling pathway_Homo sapiens_hsa049170.35367245

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »