KLF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heme biosynthetic process (GO:0006783)9.68069330
2porphyrin-containing compound biosynthetic process (GO:0006779)8.87396466
3tetrapyrrole biosynthetic process (GO:0033014)7.94976266
4heme metabolic process (GO:0042168)7.94399243
5porphyrin-containing compound metabolic process (GO:0006778)7.25957777
6negative regulation of erythrocyte differentiation (GO:0045647)6.15149571
7DNA deamination (GO:0045006)5.38438211
8erythrocyte development (GO:0048821)5.28410550
9ribosomal small subunit assembly (GO:0000028)5.03362795
10definitive hemopoiesis (GO:0060216)4.89510187
11telomere maintenance via semi-conservative replication (GO:0032201)4.85264874
12DNA strand elongation involved in DNA replication (GO:0006271)4.79084692
13positive regulation of megakaryocyte differentiation (GO:0045654)4.78044264
14DNA replication initiation (GO:0006270)4.75905877
15tetrapyrrole metabolic process (GO:0033013)4.74897592
16pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.74488996
17pigment biosynthetic process (GO:0046148)4.70446234
18DNA strand elongation (GO:0022616)4.55170883
19viral transcription (GO:0019083)4.45944569
20DNA topological change (GO:0006265)4.32387299
21translational termination (GO:0006415)4.31305305
22pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.28409703
23deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.27982905
24DNA replication checkpoint (GO:0000076)4.21155406
25regulation of response to osmotic stress (GO:0047484)4.20534096
26cellular response to thyroid hormone stimulus (GO:0097067)4.18764714
27one-carbon compound transport (GO:0019755)4.11986167
28positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)4.11317225
29pigment metabolic process (GO:0042440)4.05693007
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.04500524
31folic acid-containing compound biosynthetic process (GO:0009396)4.02500978
32positive regulation of granulocyte differentiation (GO:0030854)3.98560565
33telomere maintenance via recombination (GO:0000722)3.97361331
34proteasome assembly (GO:0043248)3.96941089
35translational elongation (GO:0006414)3.94280326
36pyrimidine nucleotide catabolic process (GO:0006244)3.86873303
37CENP-A containing nucleosome assembly (GO:0034080)3.84678838
38protein autoprocessing (GO:0016540)3.83888823
39granulocyte differentiation (GO:0030851)3.78411490
40potassium ion export (GO:0071435)3.77024639
41positive regulation of erythrocyte differentiation (GO:0045648)3.75936464
42SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.72598957
43response to lead ion (GO:0010288)3.66374704
44chromatin remodeling at centromere (GO:0031055)3.64534167
45cotranslational protein targeting to membrane (GO:0006613)3.63106522
46protein targeting to ER (GO:0045047)3.62880974
47DNA unwinding involved in DNA replication (GO:0006268)3.59152148
48mitotic recombination (GO:0006312)3.55877005
49myeloid cell development (GO:0061515)3.51407711
50ribosomal small subunit biogenesis (GO:0042274)3.48455657
51response to methylmercury (GO:0051597)3.46733061
52establishment of protein localization to endoplasmic reticulum (GO:0072599)3.45690667
53translational initiation (GO:0006413)3.45535310
54DNA replication-independent nucleosome assembly (GO:0006336)3.44543967
55DNA replication-independent nucleosome organization (GO:0034724)3.44543967
56hemoglobin metabolic process (GO:0020027)3.44482342
57protein localization to endoplasmic reticulum (GO:0070972)3.44240807
58nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.42041124
59deoxyribonucleotide biosynthetic process (GO:0009263)3.41977638
60glycine transport (GO:0015816)3.40494758
61deoxyribose phosphate biosynthetic process (GO:0046385)3.40476102
622-deoxyribonucleotide biosynthetic process (GO:0009265)3.40476102
63* erythrocyte differentiation (GO:0030218)3.37472280
64maturation of SSU-rRNA (GO:0030490)3.36311613
65cellular protein complex disassembly (GO:0043624)3.35977973
66* erythrocyte maturation (GO:0043249)3.34272616
67telomere maintenance via telomere lengthening (GO:0010833)3.33841431
68response to thyroid hormone (GO:0097066)3.33799824
69viral life cycle (GO:0019058)3.32315295
70metallo-sulfur cluster assembly (GO:0031163)3.31502653
71iron-sulfur cluster assembly (GO:0016226)3.31502653
72positive regulation of B cell differentiation (GO:0045579)3.28326105
73folic acid metabolic process (GO:0046655)3.25115354
74protein localization to chromosome, centromeric region (GO:0071459)3.25099967
75regulation of erythrocyte differentiation (GO:0045646)3.23786515
76platelet formation (GO:0030220)3.19563938
77nucleotide-excision repair, DNA gap filling (GO:0006297)3.17072376
78gas transport (GO:0015669)3.16673689
79lysine catabolic process (GO:0006554)3.16477673
80lysine metabolic process (GO:0006553)3.16477673
81DNA replication-dependent nucleosome organization (GO:0034723)3.16134960
82DNA replication-dependent nucleosome assembly (GO:0006335)3.16134960
83pseudouridine synthesis (GO:0001522)3.15297743
84response to insecticide (GO:0017085)3.12718172
85purine-containing compound salvage (GO:0043101)3.12492809
86megakaryocyte development (GO:0035855)3.11422957
87kinetochore organization (GO:0051383)3.10932481
88protein localization to kinetochore (GO:0034501)3.03359297
89pteridine-containing compound biosynthetic process (GO:0042559)2.99290525
90formation of translation preinitiation complex (GO:0001731)2.98796651
91IMP biosynthetic process (GO:0006188)2.98623888
92kinetochore assembly (GO:0051382)2.98540137
93translation (GO:0006412)2.98415544
94hydrogen peroxide catabolic process (GO:0042744)2.98364782
95protein complex disassembly (GO:0043241)2.97006675
96aerobic respiration (GO:0009060)2.96700641
97modulation by virus of host process (GO:0019054)2.96088567
98cofactor biosynthetic process (GO:0051188)2.94305761
99histone exchange (GO:0043486)2.91854306
100response to arsenic-containing substance (GO:0046685)2.91689611
101ribosomal large subunit biogenesis (GO:0042273)2.90728226
102viral mRNA export from host cell nucleus (GO:0046784)2.89579690
103ribonucleoprotein complex biogenesis (GO:0022613)2.88791191
104regulation of histone H3-K9 methylation (GO:0051570)2.85920346
105negative regulation of bone mineralization (GO:0030502)2.85868071
106negative regulation of RNA splicing (GO:0033119)2.85458715
107cellular response to arsenic-containing substance (GO:0071243)2.82040624
108DNA ligation (GO:0006266)2.81580035
109mitotic nuclear envelope disassembly (GO:0007077)2.79932093
110macromolecular complex disassembly (GO:0032984)2.79861925
111negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.79449007
112* embryonic hemopoiesis (GO:0035162)2.79060333
113oxidative phosphorylation (GO:0006119)2.75095910
114protein-cofactor linkage (GO:0018065)2.74400614
115positive regulation of insulin receptor signaling pathway (GO:0046628)2.74268747
116nuclear-transcribed mRNA catabolic process (GO:0000956)2.74026865
117iron ion import (GO:0097286)2.73348498
118regulation of megakaryocyte differentiation (GO:0045652)2.72252962
119mitotic sister chromatid segregation (GO:0000070)2.71623002
120pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.70750930
121ribosome biogenesis (GO:0042254)2.70713124
122chromatin assembly or disassembly (GO:0006333)2.69948158
123rRNA processing (GO:0006364)2.69794000
124spliceosomal snRNP assembly (GO:0000387)2.69769335
125exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.67699908
126translesion synthesis (GO:0019985)2.67679921
127proline biosynthetic process (GO:0006561)2.65509903
128deoxyribonucleotide catabolic process (GO:0009264)2.65122600
129regulation of granulocyte differentiation (GO:0030852)2.63792922
130regulation of RNA export from nucleus (GO:0046831)2.62530779
1313-UTR-mediated mRNA stabilization (GO:0070935)2.61758061
1322-deoxyribonucleotide metabolic process (GO:0009394)2.56966889
133regulation of histone H3-K4 methylation (GO:0051569)2.56898557
134deoxyribose phosphate catabolic process (GO:0046386)2.56843620
135poly(A)+ mRNA export from nucleus (GO:0016973)2.54241072
136valine metabolic process (GO:0006573)2.46848319
137very-low-density lipoprotein particle assembly (GO:0034379)2.45709428
138deoxyribose phosphate metabolic process (GO:0019692)2.43538300
139negative regulation of biomineral tissue development (GO:0070168)2.41635180
140purine nucleobase metabolic process (GO:0006144)2.38521429
141short-chain fatty acid metabolic process (GO:0046459)2.38250070
142* hemopoiesis (GO:0030097)2.33353521
143pentose-phosphate shunt (GO:0006098)2.32779594
144modulation by symbiont of host cellular process (GO:0044068)2.28682880
145mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.27270229
146negative regulation of translational initiation (GO:0045947)2.25513936
147bicarbonate transport (GO:0015701)2.25350624
148purine nucleobase biosynthetic process (GO:0009113)2.25345452
149regulation of monocyte differentiation (GO:0045655)2.25255005
150iron ion homeostasis (GO:0055072)2.21618840
151mucosal-associated lymphoid tissue development (GO:0048537)2.21098299
152Peyers patch development (GO:0048541)2.21098299
153protoporphyrinogen IX metabolic process (GO:0046501)11.6931923
154protoporphyrinogen IX biosynthetic process (GO:0006782)11.3573458
155oxygen transport (GO:0015671)10.1229509

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.67923356
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse5.52306276
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.66343186
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.33042344
5GATA1_22025678_ChIP-Seq_K562_Human3.25953756
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.15511727
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74449927
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67199350
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65001398
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.64688695
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.59298450
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.52762037
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.52419738
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.50150305
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37833352
16* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.36566007
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.31242462
18SCL_19346495_ChIP-Seq_HPC-7_Human2.30771697
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28451156
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.26943740
21TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.21862378
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18940546
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18360392
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17345399
25VDR_23849224_ChIP-Seq_CD4+_Human2.12434138
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11370329
27XRN2_22483619_ChIP-Seq_HELA_Human2.06546590
28GATA1_22383799_ChIP-Seq_G1ME_Mouse2.03458583
29* GATA1_19941827_ChIP-Seq_MEL_Mouse2.02543112
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93842480
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92148570
32DCP1A_22483619_ChIP-Seq_HELA_Human1.88496624
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84588873
34FOXP3_21729870_ChIP-Seq_TREG_Human1.82154763
35* NCOR1_26117541_ChIP-Seq_K562_Human1.81247590
36* E2F1_21310950_ChIP-Seq_MCF-7_Human1.80050874
37AR_21909140_ChIP-Seq_LNCAP_Human1.80028440
38GABP_19822575_ChIP-Seq_HepG2_Human1.79361691
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79325013
40MYC_22102868_ChIP-Seq_BL_Human1.78366626
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.74522552
42* GATA1_19941826_ChIP-Seq_K562_Human1.71566500
43* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.69565718
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68735560
45* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61784905
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.60158400
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60098051
48TTF2_22483619_ChIP-Seq_HELA_Human1.54943113
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53409765
50VDR_21846776_ChIP-Seq_THP-1_Human1.53353773
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49816594
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46030607
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44690444
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.43664959
55CIITA_25753668_ChIP-Seq_RAJI_Human1.43098673
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40858853
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40240944
58ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.34204629
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33343046
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31283091
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30409246
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29243430
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27700515
64CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24832797
65* KDM5A_27292631_Chip-Seq_BREAST_Human1.24096997
66* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23989010
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23556812
68E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22852367
69EGR1_19374776_ChIP-ChIP_THP-1_Human1.22050595
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20788227
71ELK1_19687146_ChIP-ChIP_HELA_Human1.19737989
72ZNF263_19887448_ChIP-Seq_K562_Human1.18711389
73MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16997711
74* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15889658
75* MAF_26560356_Chip-Seq_TH1_Human1.15874542
76UTX_26944678_Chip-Seq_JUKART_Human1.14722697
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14236936
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12160845
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11951825
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10359214
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10335058
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09499087
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07812109
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07682083
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.07084043
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07047614
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05888058
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05647462
89GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05481219
90PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05233888
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04862562
92NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04238940
93BCL6_27268052_Chip-Seq_Bcells_Human1.01746390
94KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98607777
95BCOR_27268052_Chip-Seq_Bcells_Human0.98206763
96TFEB_21752829_ChIP-Seq_HELA_Human0.98130556
97* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98129773
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96526137
99CTCF_21964334_Chip-Seq_Bcells_Human0.96320002
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96294450
101VDR_24763502_ChIP-Seq_THP-1_Human0.95804979
102* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94284094
103P68_20966046_ChIP-Seq_HELA_Human0.93927078
104CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93898778
105ELK3_25401928_ChIP-Seq_HUVEC_Human0.93822128
106BP1_19119308_ChIP-ChIP_Hs578T_Human0.93491396
107* GATA2_19941826_ChIP-Seq_K562_Human0.90517454
108STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90211550
109MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89115734
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89014915
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.87194426
112* RUNX1_22412390_ChIP-Seq_EML_Mouse0.86974304
113SPI1_23547873_ChIP-Seq_NB4_Human0.83884981
114LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83821924
115CTCF_18555785_ChIP-Seq_MESCs_Mouse0.82756890
116ELF1_20517297_ChIP-Seq_JURKAT_Human0.82290764
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82025043

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level9.23297986
2* MP0003656_abnormal_erythrocyte_physiolo8.42689844
3MP0006054_spinal_hemorrhage3.86696498
4MP0003111_abnormal_nucleus_morphology3.78823937
5MP0003693_abnormal_embryo_hatching3.44245329
6MP0010094_abnormal_chromosome_stability3.32162091
7MP0003806_abnormal_nucleotide_metabolis2.94067345
8MP0002396_abnormal_hematopoietic_system2.92302296
9MP0004957_abnormal_blastocyst_morpholog2.80583944
10MP0003077_abnormal_cell_cycle2.73925130
11MP0008057_abnormal_DNA_replication2.72103882
12MP0002132_abnormal_respiratory_system2.69511422
13MP0009278_abnormal_bone_marrow2.67739945
14* MP0005397_hematopoietic_system_phenotyp2.51975013
15* MP0001545_abnormal_hematopoietic_system2.51975013
16MP0005451_abnormal_body_composition2.47969039
17MP0008058_abnormal_DNA_repair2.21924387
18MP0006036_abnormal_mitochondrial_physio2.17571282
19MP0000490_abnormal_crypts_of2.07186758
20MP0003186_abnormal_redox_activity2.01447769
21MP0008995_early_reproductive_senescence1.89631333
22MP0005083_abnormal_biliary_tract1.87440227
23MP0008007_abnormal_cellular_replicative1.82994383
24* MP0005636_abnormal_mineral_homeostasis1.80858430
25MP0009333_abnormal_splenocyte_physiolog1.65587862
26MP0003303_peritoneal_inflammation1.59001546
27MP0008775_abnormal_heart_ventricle1.57024446
28MP0004215_abnormal_myocardial_fiber1.53524898
29* MP0002398_abnormal_bone_marrow1.50193102
30MP0004145_abnormal_muscle_electrophysio1.46994403
31MP0002722_abnormal_immune_system1.37748983
32MP0000015_abnormal_ear_pigmentation1.36811824
33MP0000689_abnormal_spleen_morphology1.35861737
34MP0000313_abnormal_cell_death1.35158277
35MP0000350_abnormal_cell_proliferation1.32383004
36MP0003172_abnormal_lysosome_physiology1.31519874
37MP0002139_abnormal_hepatobiliary_system1.26799029
38MP0008932_abnormal_embryonic_tissue1.25069338
39MP0008872_abnormal_physiological_respon1.24401704
40MP0008260_abnormal_autophagy1.23881200
41* MP0002429_abnormal_blood_cell1.15813796
42MP0002019_abnormal_tumor_incidence1.13889643
43MP0001730_embryonic_growth_arrest1.13714169
44MP0010307_abnormal_tumor_latency1.09490382
45MP0000685_abnormal_immune_system1.08861062
46MP0006035_abnormal_mitochondrial_morpho1.07830480
47MP0005464_abnormal_platelet_physiology1.05324194
48MP0001873_stomach_inflammation1.04735029
49MP0009697_abnormal_copulation1.04210411
50MP0004808_abnormal_hematopoietic_stem1.02612375
51MP0003786_premature_aging0.98576412
52* MP0002080_prenatal_lethality0.96663078
53MP0000703_abnormal_thymus_morphology0.96551355
54MP0001764_abnormal_homeostasis0.95900401
55MP0000372_irregular_coat_pigmentation0.93013868
56MP0000358_abnormal_cell_content/0.91303655
57MP0005075_abnormal_melanosome_morpholog0.86723491
58MP0009379_abnormal_foot_pigmentation0.86686767
59MP0000749_muscle_degeneration0.86550274
60MP0003436_decreased_susceptibility_to0.86076130
61MP0009765_abnormal_xenobiotic_induced0.84635249
62MP0002095_abnormal_skin_pigmentation0.81484964
63MP0003724_increased_susceptibility_to0.80692285
64MP0005671_abnormal_response_to0.79139132
65MP0008770_decreased_survivor_rate0.79055226
66MP0001697_abnormal_embryo_size0.78404012
67* MP0009931_abnormal_skin_appearance0.77114056
68MP0002653_abnormal_ependyma_morphology0.76874466
69MP0005085_abnormal_gallbladder_physiolo0.75547607
70MP0001853_heart_inflammation0.75153300
71MP0001529_abnormal_vocalization0.75040389
72MP0000716_abnormal_immune_system0.74656851
73MP0005501_abnormal_skin_physiology0.73623293
74MP0010352_gastrointestinal_tract_polyps0.73591706
75MP0005360_urolithiasis0.73582154
76* MP0000609_abnormal_liver_physiology0.72281868
77* MP0000598_abnormal_liver_morphology0.71257920
78MP0002102_abnormal_ear_morphology0.70851096
79MP0009764_decreased_sensitivity_to0.69940455
80MP0005584_abnormal_enzyme/coenzyme_acti0.69852281
81MP0008469_abnormal_protein_level0.69805545
82MP0005319_abnormal_enzyme/_coenzyme0.69744594
83MP0005174_abnormal_tail_pigmentation0.69380547
84MP0001727_abnormal_embryo_implantation0.69331511
85MP0002086_abnormal_extraembryonic_tissu0.68613974
86MP0003763_abnormal_thymus_physiology0.68205737
87MP0005220_abnormal_exocrine_pancreas0.64952943
88MP0000465_gastrointestinal_hemorrhage0.62827974
89MP0002420_abnormal_adaptive_immunity0.60515292
90MP0001663_abnormal_digestive_system0.60294861
91MP0005266_abnormal_metabolism0.60116097
92MP0002419_abnormal_innate_immunity0.59913861
93MP0004043_abnormal_pH_regulation0.59752876
94MP0005499_abnormal_olfactory_system0.59386146
95MP0005394_taste/olfaction_phenotype0.59386146
96MP0001819_abnormal_immune_cell0.58623464
97MP0002405_respiratory_system_inflammati0.58489756
98MP0003191_abnormal_cellular_cholesterol0.57750638
99MP0001243_abnormal_dermal_layer0.57322313
100MP0009763_increased_sensitivity_to0.56842526
101MP0001915_intracranial_hemorrhage0.56602321
102MP0008789_abnormal_olfactory_epithelium0.55848623
103MP0005384_cellular_phenotype0.55723421
104MP0003718_maternal_effect0.55334579
105MP0009840_abnormal_foam_cell0.53869063
106MP0005076_abnormal_cell_differentiation0.53643774
107MP0005376_homeostasis/metabolism_phenot0.53304275
108MP0005647_abnormal_sex_gland0.52258190
109MP0000858_altered_metastatic_potential0.51206777
110MP0005380_embryogenesis_phenotype0.50043141
111MP0001672_abnormal_embryogenesis/_devel0.50043141
112MP0001881_abnormal_mammary_gland0.49771577
113MP0005621_abnormal_cell_physiology0.49720037
114MP0009643_abnormal_urine_homeostasis0.49388448
115MP0003984_embryonic_growth_retardation0.48806847
116MP0002009_preneoplasia0.48316715
117MP0002083_premature_death0.47530929
118MP0003567_abnormal_fetal_cardiomyocyte0.46724927
119MP0002166_altered_tumor_susceptibility0.45761006
120MP0008873_increased_physiological_sensi0.45566203
121MP0005025_abnormal_response_to0.45531816
122MP0002088_abnormal_embryonic_growth/wei0.45374262
123MP0002970_abnormal_white_adipose0.45090948
124MP0001929_abnormal_gametogenesis0.44987120
125MP0001835_abnormal_antigen_presentation0.44615395
126MP0001145_abnormal_male_reproductive0.44157809

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)9.04781284
2Acanthocytosis (HP:0001927)7.72137653
3Abnormal hemoglobin (HP:0011902)5.74010557
4* Reticulocytosis (HP:0001923)5.49451138
5* Abnormality of reticulocytes (HP:0004312)4.73097354
6Diaphragmatic weakness (HP:0009113)4.68938812
7Birth length less than 3rd percentile (HP:0003561)4.61926438
8Increased serum ferritin (HP:0003281)4.54504243
9Petechiae (HP:0000967)4.51916447
10* Abnormal number of erythroid precursors (HP:0012131)4.34581507
11* Abnormality of cells of the erythroid lineage (HP:0012130)4.29300842
12Cholelithiasis (HP:0001081)4.23952878
13Paralysis (HP:0003470)4.23598389
14* Hyperbilirubinemia (HP:0002904)4.02857809
15Abnormality of iron homeostasis (HP:0011031)3.93445548
16Polycythemia (HP:0001901)3.87261585
17Abnormal gallbladder morphology (HP:0012437)3.76867966
18Hypochromic microcytic anemia (HP:0004840)3.76782813
19Short middle phalanx of the 5th finger (HP:0004220)3.72017319
20Abnormality of transition element cation homeostasis (HP:0011030)3.63463872
21Cutaneous photosensitivity (HP:0000992)3.59099557
22Insomnia (HP:0100785)3.55662138
23Macrocytic anemia (HP:0001972)3.51101946
24Prolonged bleeding time (HP:0003010)3.47092492
25Reticulocytopenia (HP:0001896)3.45841047
26Aplastic anemia (HP:0001915)3.39370024
27* Pallor (HP:0000980)3.22767490
28Microcytic anemia (HP:0001935)3.12503350
29Ileus (HP:0002595)3.04314209
30Decreased activity of mitochondrial respiratory chain (HP:0008972)3.02967862
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.02967862
32Hypertensive crisis (HP:0100735)2.93860934
33Abnormal gallbladder physiology (HP:0012438)2.84594885
34Cholecystitis (HP:0001082)2.84594885
35Hypochromic anemia (HP:0001931)2.82486595
36Nausea (HP:0002018)2.68379111
37Abnormality of the gallbladder (HP:0005264)2.59178383
38Oral leukoplakia (HP:0002745)2.53321845
39Epistaxis (HP:0000421)2.52721351
40Hepatocellular necrosis (HP:0001404)2.50563975
41Onycholysis (HP:0001806)2.45361685
42Osteomalacia (HP:0002749)2.42005593
43Breast hypoplasia (HP:0003187)2.40643943
44Increased serum lactate (HP:0002151)2.37177148
45Visual hallucinations (HP:0002367)2.36165340
46Toxemia of pregnancy (HP:0100603)2.33762423
47Mitochondrial inheritance (HP:0001427)2.33246279
48Brushfield spots (HP:0001088)2.31806539
49Hepatic necrosis (HP:0002605)2.26991011
50Albinism (HP:0001022)2.26076526
513-Methylglutaconic aciduria (HP:0003535)2.25821948
52Hepatocellular carcinoma (HP:0001402)2.20301370
53Impaired platelet aggregation (HP:0003540)2.19777759
54Abnormal platelet function (HP:0011869)2.19777759
55Increased CSF lactate (HP:0002490)2.17738607
56Abnormal mitochondria in muscle tissue (HP:0008316)2.15447149
57Hypoparathyroidism (HP:0000829)2.13023619
58Acute necrotizing encephalopathy (HP:0006965)2.12544073
59Hyponatremia (HP:0002902)2.12528050
60Microvesicular hepatic steatosis (HP:0001414)2.11568517
61Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.11387107
62Increased intramyocellular lipid droplets (HP:0012240)2.11153463
63Lipid accumulation in hepatocytes (HP:0006561)2.06405695
64Aplasia/Hypoplasia of the sacrum (HP:0008517)2.04495243
65Severe visual impairment (HP:0001141)2.03959625
66* Abnormality of the heme biosynthetic pathway (HP:0010472)13.8128681
67Increased hepatocellular lipid droplets (HP:0006565)1.99479709
68Increased muscle lipid content (HP:0009058)1.98986624
69Microretrognathia (HP:0000308)1.97752684
70Hyperthyroidism (HP:0000836)1.97554522
71Broad palm (HP:0001169)1.95347279
72Myelodysplasia (HP:0002863)1.95084458
73Reduced antithrombin III activity (HP:0001976)1.94676427
74Delusions (HP:0000746)1.93210566
75Pancytopenia (HP:0001876)1.92806568
76Abnormality of dental color (HP:0011073)1.92181520
77Exertional dyspnea (HP:0002875)1.91469022
78Small intestinal stenosis (HP:0012848)1.91371189
79Duodenal stenosis (HP:0100867)1.91371189
80Abnormal spermatogenesis (HP:0008669)1.90491062
81Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.89228257
82Cerebral palsy (HP:0100021)1.89086026
83Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88238052
84Lactic acidosis (HP:0003128)1.88123347
85Cerebral hypomyelination (HP:0006808)1.88105378
86Acute encephalopathy (HP:0006846)1.86378533
87Basal cell carcinoma (HP:0002671)1.86182686
88Hypoplasia of the pons (HP:0012110)1.85801172
89Aplasia/Hypoplasia of the earlobes (HP:0009906)1.85485802
90Spastic paraparesis (HP:0002313)1.84958053
91Panhypogammaglobulinemia (HP:0003139)1.81659366
92Type I transferrin isoform profile (HP:0003642)1.80823239
93Abnormality of the pons (HP:0007361)1.80710770
94Pustule (HP:0200039)1.80113589
95Abnormality of sodium homeostasis (HP:0010931)1.79778171
96Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78778258
97Short 5th finger (HP:0009237)1.76386899
98Ventricular fibrillation (HP:0001663)1.75465494
99Seborrheic dermatitis (HP:0001051)1.74715415
100Skin rash (HP:0000988)1.72396561
101Abnormal platelet volume (HP:0011876)1.71619673
102Nonimmune hydrops fetalis (HP:0001790)1.70861700
103Abnormality of the fingertips (HP:0001211)1.70796066
104Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.69792001
105Increased mean platelet volume (HP:0011877)1.69320088
106Azoospermia (HP:0000027)1.69126687
107Abnormality of the preputium (HP:0100587)1.69050019
108Global brain atrophy (HP:0002283)1.67811974
109Hypopigmented skin patches (HP:0001053)1.66926834
110Neoplasm of head and neck (HP:0012288)1.66755568
111Esophageal neoplasm (HP:0100751)1.66755568
112Patellar aplasia (HP:0006443)1.65899572
113Gastrointestinal dysmotility (HP:0002579)1.65062202
114Irregular epiphyses (HP:0010582)1.64821728
115Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.63843411
116Chromsome breakage (HP:0040012)1.63198740
117Multiple enchondromatosis (HP:0005701)1.62847975
118Abnormality of chromosome stability (HP:0003220)1.62105221
119Generalized hyperpigmentation (HP:0007440)1.60340902
120Respiratory failure (HP:0002878)1.59225553
121Orthostatic hypotension (HP:0001278)1.59097779
122Cafe-au-lait spot (HP:0000957)1.58741800
123Respiratory difficulties (HP:0002880)1.57501255
124Obstructive lung disease (HP:0006536)1.57049061
125Chronic obstructive pulmonary disease (HP:0006510)1.57049061
126Ragged-red muscle fibers (HP:0003200)1.56727232
127Recurrent viral infections (HP:0004429)1.56014341
128Slow saccadic eye movements (HP:0000514)1.53738001
129Truncus arteriosus (HP:0001660)1.52852989
130Dicarboxylic aciduria (HP:0003215)1.52655343
131Abnormality of dicarboxylic acid metabolism (HP:0010995)1.52655343
132Osteomyelitis (HP:0002754)1.52080283
133Abnormal blistering of the skin (HP:0008066)1.50508546
134Anhidrosis (HP:0000970)1.50218381
135Cellulitis (HP:0100658)1.49300741
136Gastrointestinal infarctions (HP:0005244)1.47330789
137Hyperammonemia (HP:0001987)1.46308920
138Hypoplastic iliac wings (HP:0002866)1.45132096
139Hepatosplenomegaly (HP:0001433)1.44867772
140Gingival bleeding (HP:0000225)1.44041397
141Premature ovarian failure (HP:0008209)1.43449070
142Bone marrow hypocellularity (HP:0005528)1.43206232
143Emotional lability (HP:0000712)1.41184537
144Increased IgM level (HP:0003496)1.40851362
145Gastrointestinal inflammation (HP:0004386)1.40817220

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK15.23914412
2NME24.37631733
3CDC73.81422763
4VRK23.46114403
5BUB13.12514141
6STK163.03973459
7WEE12.95021312
8PRPF4B2.78292153
9TAOK22.72553705
10VRK12.68616177
11SCYL22.48355125
12DYRK32.42508794
13TLK12.38159108
14NEK22.28070466
15BRSK12.18630720
16BRSK22.08501747
17PIM21.99486920
18CDK191.95814833
19NUAK11.90724233
20NEK11.80257896
21MAP3K101.79736821
22STK41.63625018
23STK101.61282086
24KDR1.60630947
25EEF2K1.58799461
26ACVR1B1.54167377
27MAP3K111.52221958
28MAP4K21.49081541
29MAPKAPK51.44739201
30BMX1.41291825
31SMG11.34320884
32MAP4K11.32214106
33AURKB1.29605787
34ATR1.27481789
35ERN11.26866205
36AURKA1.26416764
37PLK11.26150684
38SRPK11.25691977
39MATK1.24784862
40MAPK111.15774700
41TTK1.15711663
42PIM11.13621307
43MAP3K81.12376171
44CDK41.11841073
45CDK71.11226582
46MAP3K11.11018073
47FLT31.06804826
48LRRK21.03026627
49EIF2AK31.02388504
50NME11.02238887
51CHEK21.02083353
52MAP3K30.99001457
53RPS6KA40.98411432
54RIPK40.97906889
55RPS6KB20.95886005
56CDK80.90520882
57ABL20.89661815
58JAK20.85938897
59TYK20.85296469
60BCKDK0.84983534
61TEC0.84772310
62TNIK0.84743919
63BTK0.79344999
64TAOK30.79064623
65MARK30.78371781
66CHEK10.75106159
67IRAK30.74728489
68HIPK20.74585188
69TSSK60.74105880
70MAPKAPK30.72510238
71PKN20.72509998
72TAF10.72456780
73CCNB10.72402895
74ZAK0.71977911
75RPS6KA50.71515406
76MAP3K50.71315636
77MKNK10.68406847
78TGFBR20.67426415
79DYRK20.64472026
80MAP2K30.60875026
81TAOK10.60269161
82RAF10.57369784
83* ATM0.57159763
84LYN0.56658616
85MUSK0.56506086
86EIF2AK20.56273089
87SYK0.56207714
88BRAF0.55599373
89TESK10.54647581
90TNK20.54620644
91CLK10.53635001
92GRK60.53349052
93IKBKB0.53078895
94MKNK20.52822986
95TBK10.52313681
96MAP2K20.51896784
97* CSNK2A10.51656011
98WNK10.51305514
99CDK20.50855381
100* CSNK2A20.50596068
101KIT0.49857070
102PLK40.49471898
103TESK20.48749070
104MAP2K10.47287376
105MAPK30.47068607
106PBK0.46516247
107MAP3K60.45771420
108PAK20.45524109
109RPS6KL10.45020321
110RPS6KC10.45020321
111TRIB30.44548250
112TRPM70.41879750
113MST40.41602267
114DAPK10.40720361
115CDK10.40270053
116MAPKAPK20.39471060
117JAK30.37679931
118PLK30.36383829
119AKT10.36038753
120CDK60.35691050
121PAK10.33937063
122FES0.33571712
123TGFBR10.33259387
124AKT20.33073817
125CDK11A0.32762074
126RPS6KA60.29536368
127DYRK1B0.28858601
128MAPK120.28605672
129MAPK90.28306024
130PASK0.27287967
131PAK40.27260169
132BLK0.27036857
133MAPK40.26046702

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008605.81946963
2DNA replication_Homo sapiens_hsa030305.47817619
3Ribosome_Homo sapiens_hsa030104.16250848
4Mismatch repair_Homo sapiens_hsa034303.51515611
5Nucleotide excision repair_Homo sapiens_hsa034202.63391216
6Spliceosome_Homo sapiens_hsa030402.60957486
7Base excision repair_Homo sapiens_hsa034102.55898450
8Proteasome_Homo sapiens_hsa030502.53401278
9Pyrimidine metabolism_Homo sapiens_hsa002402.53349313
10Homologous recombination_Homo sapiens_hsa034402.43625792
11RNA polymerase_Homo sapiens_hsa030202.31916556
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.28434988
13Cell cycle_Homo sapiens_hsa041102.27432031
14One carbon pool by folate_Homo sapiens_hsa006702.26893245
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.25815608
16Systemic lupus erythematosus_Homo sapiens_hsa053222.13869770
17Nitrogen metabolism_Homo sapiens_hsa009102.07953801
18Sulfur relay system_Homo sapiens_hsa041222.07473705
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.97636234
20RNA transport_Homo sapiens_hsa030131.94893199
21Parkinsons disease_Homo sapiens_hsa050121.68792115
22Fanconi anemia pathway_Homo sapiens_hsa034601.66145563
23Non-homologous end-joining_Homo sapiens_hsa034501.62060984
24Fatty acid elongation_Homo sapiens_hsa000621.59558673
25RNA degradation_Homo sapiens_hsa030181.46123719
26Vitamin B6 metabolism_Homo sapiens_hsa007501.46097620
27p53 signaling pathway_Homo sapiens_hsa041151.40776252
28Folate biosynthesis_Homo sapiens_hsa007901.40175172
29Oxidative phosphorylation_Homo sapiens_hsa001901.36727681
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.33134657
31Purine metabolism_Homo sapiens_hsa002301.27312054
32Basal transcription factors_Homo sapiens_hsa030221.25387844
33Huntingtons disease_Homo sapiens_hsa050161.24475878
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24273337
35Pentose phosphate pathway_Homo sapiens_hsa000301.23281757
36Selenocompound metabolism_Homo sapiens_hsa004501.22827096
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16600313
38Regulation of autophagy_Homo sapiens_hsa041401.14397018
39Fatty acid metabolism_Homo sapiens_hsa012120.99399120
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97376525
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95266767
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94352493
43Alcoholism_Homo sapiens_hsa050340.92950637
44Protein export_Homo sapiens_hsa030600.90529061
45ABC transporters_Homo sapiens_hsa020100.89295401
46Sulfur metabolism_Homo sapiens_hsa009200.88209196
47African trypanosomiasis_Homo sapiens_hsa051430.86054160
48Hematopoietic cell lineage_Homo sapiens_hsa046400.85453583
49Glutathione metabolism_Homo sapiens_hsa004800.84268691
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.83858437
51Herpes simplex infection_Homo sapiens_hsa051680.82991185
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82713528
53Caffeine metabolism_Homo sapiens_hsa002320.82432865
54Glycerophospholipid metabolism_Homo sapiens_hsa005640.80956299
55Alzheimers disease_Homo sapiens_hsa050100.80116277
56mRNA surveillance pathway_Homo sapiens_hsa030150.78088566
57Pancreatic cancer_Homo sapiens_hsa052120.73807998
58Biosynthesis of amino acids_Homo sapiens_hsa012300.72397868
59Viral carcinogenesis_Homo sapiens_hsa052030.70463647
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70371969
61Collecting duct acid secretion_Homo sapiens_hsa049660.69996605
62Fructose and mannose metabolism_Homo sapiens_hsa000510.67394695
63Butanoate metabolism_Homo sapiens_hsa006500.64523655
64Bladder cancer_Homo sapiens_hsa052190.62643774
65Carbon metabolism_Homo sapiens_hsa012000.61525555
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61321462
67Pyruvate metabolism_Homo sapiens_hsa006200.60873746
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58037415
69Metabolic pathways_Homo sapiens_hsa011000.57535871
70Epstein-Barr virus infection_Homo sapiens_hsa051690.54894006
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54356327
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52605636
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.52311079
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50401706
75N-Glycan biosynthesis_Homo sapiens_hsa005100.49280141
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47270475
77Apoptosis_Homo sapiens_hsa042100.46602139
78Antigen processing and presentation_Homo sapiens_hsa046120.46327472
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44631446
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44360790
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43419388
82Small cell lung cancer_Homo sapiens_hsa052220.42804121
83Oocyte meiosis_Homo sapiens_hsa041140.37567511
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37469285
85Thyroid cancer_Homo sapiens_hsa052160.36615622
86Chronic myeloid leukemia_Homo sapiens_hsa052200.36115986
87Measles_Homo sapiens_hsa051620.35800939
88Hepatitis B_Homo sapiens_hsa051610.33766216
89Platelet activation_Homo sapiens_hsa046110.33690993
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32143173
91Peroxisome_Homo sapiens_hsa041460.32078135
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.30646245
93B cell receptor signaling pathway_Homo sapiens_hsa046620.28716483
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27392175
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.27381541
96AMPK signaling pathway_Homo sapiens_hsa041520.26830181
97Legionellosis_Homo sapiens_hsa051340.26404380
98Malaria_Homo sapiens_hsa051440.26250380
99HTLV-I infection_Homo sapiens_hsa051660.25198497
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25132325
101Tyrosine metabolism_Homo sapiens_hsa003500.24800033
102Fatty acid degradation_Homo sapiens_hsa000710.24662623
103Cardiac muscle contraction_Homo sapiens_hsa042600.24632370
104Non-small cell lung cancer_Homo sapiens_hsa052230.24516619
105mTOR signaling pathway_Homo sapiens_hsa041500.23441898
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22884281
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21056210
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21032492
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21027460
110beta-Alanine metabolism_Homo sapiens_hsa004100.20507362
111HIF-1 signaling pathway_Homo sapiens_hsa040660.20327675
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.19572114
113Acute myeloid leukemia_Homo sapiens_hsa052210.19247028
114Arginine and proline metabolism_Homo sapiens_hsa003300.14693258
115Galactose metabolism_Homo sapiens_hsa000520.11854067
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.08657280
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.07892515
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.06145620
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.06138264
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.05299929
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.05079348
122Linoleic acid metabolism_Homo sapiens_hsa005910.04813306
123Fat digestion and absorption_Homo sapiens_hsa049750.04748021
124Influenza A_Homo sapiens_hsa051640.04620207
125Propanoate metabolism_Homo sapiens_hsa006400.03822944
126Primary immunodeficiency_Homo sapiens_hsa053400.02295275

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