KLF11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)7.46049365
2positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)7.10401405
3piRNA metabolic process (GO:0034587)6.83655885
4maintenance of protein location in nucleus (GO:0051457)5.93876237
5regulation of meiosis I (GO:0060631)5.73898676
6regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)5.57355147
7monoubiquitinated protein deubiquitination (GO:0035520)5.43795761
8mitotic chromosome condensation (GO:0007076)5.02890562
9histone H4-K12 acetylation (GO:0043983)4.97715317
10embryonic retina morphogenesis in camera-type eye (GO:0060059)4.91553129
11DNA methylation involved in gamete generation (GO:0043046)4.64768244
12positive regulation of DNA-templated transcription, elongation (GO:0032786)4.60935507
13regulation of RNA export from nucleus (GO:0046831)4.39111388
14regulation of spindle checkpoint (GO:0090231)4.38631673
15protein localization to chromosome, centromeric region (GO:0071459)4.32585730
16oocyte development (GO:0048599)4.20978511
17sister chromatid cohesion (GO:0007062)4.18201317
18response to peptidoglycan (GO:0032494)4.15404576
19regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.09415211
20regulation of nucleobase-containing compound transport (GO:0032239)4.08080828
21negative regulation of erythrocyte differentiation (GO:0045647)4.01059155
22histone H3-K4 trimethylation (GO:0080182)4.00416600
23negative regulation of cAMP-mediated signaling (GO:0043951)3.97648289
24neutrophil activation involved in immune response (GO:0002283)3.95708114
25DNA replication-dependent nucleosome assembly (GO:0006335)3.94015581
26DNA replication-dependent nucleosome organization (GO:0034723)3.94015581
27histone H3-K36 demethylation (GO:0070544)3.92877710
28regulation of female gonad development (GO:2000194)3.89073996
29histone H2B ubiquitination (GO:0033523)3.86605857
30pre-miRNA processing (GO:0031054)3.85481683
31regulation of DNA methylation (GO:0044030)3.77634407
32histone H3-K9 demethylation (GO:0033169)3.76721227
33DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.75108756
34maintenance of protein localization in organelle (GO:0072595)3.74004121
35regulation of acrosome reaction (GO:0060046)3.71893122
36chromatin assembly or disassembly (GO:0006333)3.65890415
37nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.63877472
38* regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.62529619
39nuclear pore complex assembly (GO:0051292)3.62467212
40regulation of hippo signaling (GO:0035330)3.62334327
41DNA damage response, signal transduction resulting in transcription (GO:0042772)3.61292279
42cellular response to thyroid hormone stimulus (GO:0097067)3.60300345
43regulation of keratinocyte proliferation (GO:0010837)3.55622684
44mitotic metaphase plate congression (GO:0007080)3.52331589
45regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.50859783
46regulation of mitotic spindle checkpoint (GO:1903504)3.50859783
47RNA stabilization (GO:0043489)3.49600885
48mRNA stabilization (GO:0048255)3.49600885
49DNA alkylation (GO:0006305)3.47704035
50DNA methylation (GO:0006306)3.47704035
51embryonic camera-type eye morphogenesis (GO:0048596)3.47494951
52regulation of transcription from RNA polymerase III promoter (GO:0006359)3.46799798
53histone H3 acetylation (GO:0043966)3.46020297
54regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.45449528
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.45380106
56intestinal epithelial cell development (GO:0060576)3.44353078
57embryonic eye morphogenesis (GO:0048048)3.43395518
58regulation of interleukin-8 biosynthetic process (GO:0045414)3.42572810
59chromatin assembly (GO:0031497)3.29444773
60RNA destabilization (GO:0050779)3.23448480
61kinetochore assembly (GO:0051382)3.22921673
62radial glial cell differentiation (GO:0060019)3.22518810
63histone H2A monoubiquitination (GO:0035518)3.21967614
64positive regulation of cell cycle checkpoint (GO:1901978)3.20979323
65negative regulation of DNA-templated transcription, elongation (GO:0032785)3.20786727
66negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.20786727
67protein K11-linked deubiquitination (GO:0035871)3.18520562
68mitotic sister chromatid segregation (GO:0000070)3.17034932
69regulation of DNA-templated transcription, elongation (GO:0032784)3.16982085
70histone H3-K9 modification (GO:0061647)3.16590624
71spindle assembly involved in mitosis (GO:0090307)3.15051881
72histone H3-K4 methylation (GO:0051568)3.13475962
73negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.13271957
74regulation of exit from mitosis (GO:0007096)3.12504050
75response to muramyl dipeptide (GO:0032495)3.12176221
76cellular extravasation (GO:0045123)3.10191643
77regulation of T-helper 2 cell differentiation (GO:0045628)3.09890966
78dorsal/ventral axis specification (GO:0009950)3.09215846
79detection of molecule of bacterial origin (GO:0032490)3.07708702
80positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.07516648
81nuclear pore organization (GO:0006999)3.06318690
82histone H3-K9 methylation (GO:0051567)3.05645559
83multicellular organism reproduction (GO:0032504)3.05339552
84negative regulation of histone methylation (GO:0031061)3.04999626
85cellular response to fluid shear stress (GO:0071498)3.03425498
86female gamete generation (GO:0007292)3.02623619
87metaphase plate congression (GO:0051310)3.00726076
88regulation of cell cycle checkpoint (GO:1901976)3.00074671
89adipose tissue development (GO:0060612)2.99953692
90histone monoubiquitination (GO:0010390)2.98295025
91DNA packaging (GO:0006323)2.97260759
92gonadal mesoderm development (GO:0007506)2.96686960
93positive regulation of fat cell differentiation (GO:0045600)2.95968399
94paraxial mesoderm development (GO:0048339)2.95709440
95positive regulation by symbiont of host defense response (GO:0052509)2.93934147
96modulation by symbiont of host defense response (GO:0052031)2.93934147
97modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.93934147
98modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.93934147
99positive regulation by organism of defense response of other organism involved in symbiotic interact2.93934147
100modulation by symbiont of host immune response (GO:0052553)2.93934147
101early endosome to late endosome transport (GO:0045022)2.93761439
102response to laminar fluid shear stress (GO:0034616)2.92997719
103regulation of spindle organization (GO:0090224)2.92850534
104cartilage morphogenesis (GO:0060536)2.92036987
105peptidyl-lysine trimethylation (GO:0018023)2.91569896
106negative regulation of mRNA processing (GO:0050686)2.90299080
107corticosteroid receptor signaling pathway (GO:0031958)2.89632163
108positive regulation of gene expression, epigenetic (GO:0045815)2.89386868
109regulation of heterotypic cell-cell adhesion (GO:0034114)2.89093073
110macrophage activation involved in immune response (GO:0002281)2.88085406
111detection of other organism (GO:0098543)2.87754678
112interleukin-6-mediated signaling pathway (GO:0070102)2.87209129
113meiotic cell cycle (GO:0051321)2.84843063
114negative regulation of interleukin-8 production (GO:0032717)2.83788603
115response to thyroid hormone (GO:0097066)2.83468223
116kinetochore organization (GO:0051383)2.83062087
117histone lysine demethylation (GO:0070076)2.81437934
118protein localization to kinetochore (GO:0034501)2.80958468
119regulation of type B pancreatic cell apoptotic process (GO:2000674)2.80871054
120negative regulation of cell cycle arrest (GO:0071157)2.79967999
121positive regulation of histone H3-K4 methylation (GO:0051571)2.79940382
122sulfate transmembrane transport (GO:1902358)2.77784642
123positive regulation of mast cell activation (GO:0033005)2.76241581
124low-density lipoprotein particle clearance (GO:0034383)2.75720507
125N-terminal protein amino acid acetylation (GO:0006474)2.75046330
126neural tube formation (GO:0001841)2.74703707
127complement activation, alternative pathway (GO:0006957)2.73371844
128positive regulation of humoral immune response (GO:0002922)2.73337173
129pore complex assembly (GO:0046931)2.73044505
130sister chromatid segregation (GO:0000819)2.71801577
131centrosome localization (GO:0051642)2.71228429
132histone demethylation (GO:0016577)2.70545378
133regulation of cytokine production involved in inflammatory response (GO:1900015)2.69959378
134regulation of mast cell degranulation (GO:0043304)2.69658459
135positive regulation of meiosis (GO:0045836)2.69390379
136regulation of early endosome to late endosome transport (GO:2000641)2.69249673
137microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.69113293
138DNA methylation or demethylation (GO:0044728)2.67929888
139heterochromatin organization (GO:0070828)2.67032279
140regulation of sister chromatid cohesion (GO:0007063)2.66660716
141response to pheromone (GO:0019236)2.66281014
142regulation of p38MAPK cascade (GO:1900744)2.64475957
143glucocorticoid receptor signaling pathway (GO:0042921)2.64039489
144histone H2A acetylation (GO:0043968)2.61899989
145cellular response to arsenic-containing substance (GO:0071243)2.61694831
146ribosome biogenesis (GO:0042254)2.61345341
147gene silencing by RNA (GO:0031047)2.59693940
148histone phosphorylation (GO:0016572)2.59573617
149DNA replication checkpoint (GO:0000076)2.58976325
150regulation of mast cell activation involved in immune response (GO:0033006)2.58501428
151male meiosis (GO:0007140)2.55893356
152synapsis (GO:0007129)2.53317415
153positive regulation of cellular amide metabolic process (GO:0034250)2.52100480
154positive regulation of mast cell activation involved in immune response (GO:0033008)2.51750471
155positive regulation of mast cell degranulation (GO:0043306)2.51750471
156protein dealkylation (GO:0008214)2.51746206
157protein demethylation (GO:0006482)2.51746206
158detection of external biotic stimulus (GO:0098581)2.51482834
159positive regulation of coagulation (GO:0050820)2.50982698
160detection of bacterium (GO:0016045)2.50894202
161positive regulation of meiotic cell cycle (GO:0051446)2.48636014
162macrophage activation (GO:0042116)2.47361029
163reproduction (GO:0000003)2.46829582
164regulation of steroid hormone secretion (GO:2000831)2.46194832
165male meiosis I (GO:0007141)2.44763959
166regulation of histone H3-K9 methylation (GO:0051570)2.44212143
167regulation of steroid hormone biosynthetic process (GO:0090030)2.44094434
168positive regulation of hormone biosynthetic process (GO:0046886)2.43582756
169positive regulation of blood coagulation (GO:0030194)2.43544323
170positive regulation of hemostasis (GO:1900048)2.43544323
171protein carboxylation (GO:0018214)2.43007223
172peptidyl-glutamic acid carboxylation (GO:0017187)2.43007223
173regulation of mast cell activation (GO:0033003)2.42123275
174regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.39755260
175positive regulation of cholesterol efflux (GO:0010875)2.38775788
176nodal signaling pathway (GO:0038092)2.37803356
177neutrophil activation (GO:0042119)2.36432673
178synaptonemal complex assembly (GO:0007130)2.35403905
179platelet-derived growth factor receptor signaling pathway (GO:0048008)2.35082093
180response to epinephrine (GO:0071871)2.34560540
181negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.34529683
182oogenesis (GO:0048477)2.33890512
183genitalia morphogenesis (GO:0035112)2.33607619
184cellular response to epinephrine stimulus (GO:0071872)2.32920973
185detection of biotic stimulus (GO:0009595)2.32608751
186production of molecular mediator involved in inflammatory response (GO:0002532)2.32597448
187positive regulation of type 2 immune response (GO:0002830)2.31147291
188positive regulation of leukocyte degranulation (GO:0043302)2.31000962
189granulocyte activation (GO:0036230)2.29552776
190negative regulation of complement activation (GO:0045916)2.27820574
191neutrophil mediated immunity (GO:0002446)2.23819490
192regulation of leukocyte degranulation (GO:0043300)2.22698980
193leukocyte migration involved in inflammatory response (GO:0002523)2.22547648

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse7.58672235
2TP63_19390658_ChIP-ChIP_HaCaT_Human5.79048690
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.03359791
4E2F7_22180533_ChIP-Seq_HELA_Human4.60568160
5IGF1R_20145208_ChIP-Seq_DFB_Human4.05865351
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.94196110
7EZH2_22144423_ChIP-Seq_EOC_Human3.84897707
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.31993880
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.27962872
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.73501440
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.64024071
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58957221
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.58096456
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.54457559
15AR_21909140_ChIP-Seq_LNCAP_Human2.34463523
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.33402793
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32609736
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31942886
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.28247590
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.17502718
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.17502718
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.17502718
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.14705705
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12535581
25GATA1_26923725_Chip-Seq_HPCs_Mouse2.09361907
26VDR_24787735_ChIP-Seq_THP-1_Human2.06144909
27IRF8_27001747_Chip-Seq_BMDM_Mouse2.03475828
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.02726376
29E2F1_21310950_ChIP-Seq_MCF-7_Human2.02410617
30TCF4_18268006_ChIP-ChIP_LS174T_Human1.99215967
31FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.94686138
32LXR_22158963_ChIP-Seq_LIVER_Mouse1.93251897
33PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.83109998
34LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78889338
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.78493966
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.75412358
37PKCTHETA_26484144_Chip-Seq_BREAST_Human1.71984722
38SALL4_18804426_ChIP-ChIP_XEN_Mouse1.69887078
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68547215
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.68378681
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.66906814
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.66262584
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60567432
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60018602
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.58529550
46RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.56273035
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.54772492
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.54771518
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.54423881
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.53575670
51STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.49071842
52RUNX_20019798_ChIP-Seq_JUKART_Human1.48963527
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45600230
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.45510231
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.43267184
56MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.41048433
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.41035157
58TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.40481055
59CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.40453567
60* RXR_22158963_ChIP-Seq_LIVER_Mouse1.39939172
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36894252
62ISL1_27105846_Chip-Seq_CPCs_Mouse1.36409898
63TCF3_18692474_ChIP-Seq_MESCs_Mouse1.36318359
64GF1_26923725_Chip-Seq_HPCs_Mouse1.33613403
65PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32444906
66SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.32415190
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32126818
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30435277
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30178502
70AHR_22903824_ChIP-Seq_MCF-7_Human1.30018832
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29564554
72FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.27721923
73KDM5A_27292631_Chip-Seq_BREAST_Human1.27403000
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27189858
75ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.26246957
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24382650
77* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.23796758
78MYC_22102868_ChIP-Seq_BL_Human1.23538401
79VDR_24763502_ChIP-Seq_THP-1_Human1.23205709
80* TCF7_22412390_ChIP-Seq_EML_Mouse1.23048875
81GATA6_25053715_ChIP-Seq_YYC3_Human1.22593113
82* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21828752
83KDM2B_26808549_Chip-Seq_JURKAT_Human1.21092512
84NFYA_21822215_ChIP-Seq_K562_Human1.20279020
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19381228
86TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16612743
87CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16009821
88FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.15942196
89NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15843519
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15673857
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.14230698
92TBL1_22424771_ChIP-Seq_293T_Human1.13725689
93WDR5_24793694_ChIP-Seq_LNCAP_Human1.13157148
94GATA2_21666600_ChIP-Seq_HMVEC_Human1.12965437
95ESR1_21235772_ChIP-Seq_MCF-7_Human1.12599536
96PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12162937
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12147692
98BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10721194
99ELK4_26923725_Chip-Seq_MESODERM_Mouse1.10662209
100EP300_21415370_ChIP-Seq_HL-1_Mouse1.10311826
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.10300827
102SCL_19346495_ChIP-Seq_HPC-7_Human1.10132046
103CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09990126
104P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08216382
105GATA1_19941826_ChIP-Seq_K562_Human1.05468113
106EWS_26573619_Chip-Seq_HEK293_Human1.05342806
107FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05012894
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03833559
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03833559
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.03016963
111TP53_16413492_ChIP-PET_HCT116_Human1.02792246
112FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02636279
113ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01125147
114RUNX1_22412390_ChIP-Seq_EML_Mouse1.00712690
115GATA1_22025678_ChIP-Seq_K562_Human1.00624917
116SPI1_23127762_ChIP-Seq_K562_Human1.00344049
117E2F1_18555785_Chip-Seq_ESCs_Mouse1.00248623
118NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99831965
119FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99720524
120PU_27001747_Chip-Seq_BMDM_Mouse0.99618026
121TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99575674
122FOXA2_19822575_ChIP-Seq_HepG2_Human0.99224103
123CLOCK_20551151_ChIP-Seq_293T_Human0.99198774
124KDM2B_26808549_Chip-Seq_DND41_Human0.98636539
125PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96928584
126NCOR1_26117541_ChIP-Seq_K562_Human0.96600865
127* TP63_23658742_ChIP-Seq_EP156T_Human0.96434539
128KDM2B_26808549_Chip-Seq_K562_Human0.95985044
129OCT4_18555785_Chip-Seq_ESCs_Mouse0.95481669
130PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95379939
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95212566
132GATA2_19941826_ChIP-Seq_K562_Human0.95164409
133YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93887713
134HNFA_21074721_ChIP-Seq_CACO-2_Human0.93866530
135NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93791896
136* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93143493
137SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92915073
138TFEB_21752829_ChIP-Seq_HELA_Human0.92187451
139CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92095744
140FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.91875418
141PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90401764
142UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89988948
143CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89788857
144NFYB_21822215_ChIP-Seq_K562_Human0.89180699
145STAT3_18555785_Chip-Seq_ESCs_Mouse0.88666676
146RUNX1_26923725_Chip-Seq_HPCs_Mouse0.88452845
147KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88281348
148* SMRT_27268052_Chip-Seq_Bcells_Human0.87835729
149ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87576380
150SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87028253
151ELK3_25401928_ChIP-Seq_HUVEC_Human0.86078246
152RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85978543
153CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85858503
154* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85356877
155STAT3_23295773_ChIP-Seq_U87_Human0.84258666
156FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.83436142
157TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83173236
158RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.82920568
159STAT4_19710469_ChIP-ChIP_TH1__Mouse0.82731348
160* MYB_26560356_Chip-Seq_TH1_Human0.82635547
161KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.82614799
162ER_23166858_ChIP-Seq_MCF-7_Human0.82539482
163CDX2_22108803_ChIP-Seq_LS180_Human0.82232127
164KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81860402
165SOX2_27498859_Chip-Seq_STOMACH_Mouse0.81762167
166KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81680982
167ETV1_20927104_ChIP-Seq_GIST48_Human0.81623777
168GATA6_21074721_ChIP-Seq_CACO-2_Human0.81439451
169LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80243377
170AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80232522
171CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.79767846
172* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.79687614
173CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79214776
174SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.78913204
175BRD4_25478319_ChIP-Seq_HGPS_Human0.78835091
176CJUN_26792858_Chip-Seq_BT549_Human0.78796820

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005257_abnormal_intraocular_pressure7.49941807
2MP0000566_synostosis5.90621176
3MP0002139_abnormal_hepatobiliary_system4.38174100
4MP0002138_abnormal_hepatobiliary_system4.28259034
5MP0001849_ear_inflammation4.04697626
6MP0004185_abnormal_adipocyte_glucose3.67627037
7MP0002163_abnormal_gland_morphology3.42701115
8MP0001346_abnormal_lacrimal_gland3.03753984
9MP0005670_abnormal_white_adipose2.97864474
10MP0003724_increased_susceptibility_to2.89677025
11MP0003693_abnormal_embryo_hatching2.82169345
12MP0005058_abnormal_lysosome_morphology2.79031646
13MP0005451_abnormal_body_composition2.76697951
14MP0009840_abnormal_foam_cell2.75290339
15MP0010234_abnormal_vibrissa_follicle2.51486999
16MP0003787_abnormal_imprinting2.44108578
17MP0005379_endocrine/exocrine_gland_phen2.32831498
18MP0003111_abnormal_nucleus_morphology2.26850354
19MP0005365_abnormal_bile_salt2.25108905
20MP0008004_abnormal_stomach_pH2.24943459
21MP0006292_abnormal_olfactory_placode2.23952736
22MP0003718_maternal_effect2.21269396
23MP0003172_abnormal_lysosome_physiology2.21074439
24MP0000569_abnormal_digit_pigmentation2.19199264
25MP0008877_abnormal_DNA_methylation2.12957445
26MP0002009_preneoplasia2.12955499
27MP0003121_genomic_imprinting2.12265133
28MP0002396_abnormal_hematopoietic_system2.11021729
29MP0005408_hypopigmentation1.93254882
30MP0009115_abnormal_fat_cell1.87205166
31MP0000015_abnormal_ear_pigmentation1.83834640
32MP0003436_decreased_susceptibility_to1.78813378
33MP0003077_abnormal_cell_cycle1.77852614
34MP0001299_abnormal_eye_distance/1.77343528
35MP0003191_abnormal_cellular_cholesterol1.70716640
36MP0002796_impaired_skin_barrier1.67501490
37MP0002697_abnormal_eye_size1.65325793
38MP0009250_abnormal_appendicular_skeleto1.63808391
39MP0004264_abnormal_extraembryonic_tissu1.62051400
40MP0000579_abnormal_nail_morphology1.61680056
41MP0005647_abnormal_sex_gland1.57153023
42MP0005464_abnormal_platelet_physiology1.56433500
43MP0005083_abnormal_biliary_tract1.53919126
44MP0002971_abnormal_brown_adipose1.53604696
45MP0005409_darkened_coat_color1.52435149
46MP0005666_abnormal_adipose_tissue1.51966864
47MP0003303_peritoneal_inflammation1.51930933
48MP0001730_embryonic_growth_arrest1.50859102
49MP0008057_abnormal_DNA_replication1.50554161
50MP0003300_gastrointestinal_ulcer1.50018286
51MP0004510_myositis1.49911749
52MP0008260_abnormal_autophagy1.49831982
53MP0005310_abnormal_salivary_gland1.49115216
54MP0001835_abnormal_antigen_presentation1.47531332
55MP0003937_abnormal_limbs/digits/tail_de1.47025393
56MP0003123_paternal_imprinting1.45702187
57MP0002084_abnormal_developmental_patter1.45556828
58MP0000428_abnormal_craniofacial_morphol1.44828249
59MP0002419_abnormal_innate_immunity1.44361199
60MP0008995_early_reproductive_senescence1.43150823
61MP0009053_abnormal_anal_canal1.42991388
62MP0002277_abnormal_respiratory_mucosa1.42631301
63MP0005397_hematopoietic_system_phenotyp1.42612590
64MP0001545_abnormal_hematopoietic_system1.42612590
65MP0003868_abnormal_feces_composition1.40741965
66MP0003656_abnormal_erythrocyte_physiolo1.40581343
67MP0003984_embryonic_growth_retardation1.39434819
68MP0005334_abnormal_fat_pad1.37943248
69MP0002998_abnormal_bone_remodeling1.36128065
70MP0003453_abnormal_keratinocyte_physiol1.35274911
71MP0002877_abnormal_melanocyte_morpholog1.34331250
72MP0005410_abnormal_fertilization1.33721322
73MP0002088_abnormal_embryonic_growth/wei1.33263760
74MP0008007_abnormal_cellular_replicative1.30932034
75MP0005380_embryogenesis_phenotype1.30810754
76MP0001672_abnormal_embryogenesis/_devel1.30810754
77MP0002132_abnormal_respiratory_system1.29177926
78MP0006082_CNS_inflammation1.28413893
79MP0010094_abnormal_chromosome_stability1.27007972
80MP0000350_abnormal_cell_proliferation1.25069605
81MP0003879_abnormal_hair_cell1.24824564
82MP0001929_abnormal_gametogenesis1.24142320
83MP0002938_white_spotting1.22599928
84MP0003091_abnormal_cell_migration1.22381930
85MP0005084_abnormal_gallbladder_morpholo1.18853704
86MP0000750_abnormal_muscle_regeneration1.18818050
87MP0002249_abnormal_larynx_morphology1.18526157
88MP0003221_abnormal_cardiomyocyte_apopto1.16012133
89MP0002085_abnormal_embryonic_tissue1.15448804
90MP0003950_abnormal_plasma_membrane1.14880314
91MP0000613_abnormal_salivary_gland1.14779148
92MP0005197_abnormal_uvea_morphology1.14750843
93MP0001851_eye_inflammation1.14364435
94MP0004947_skin_inflammation1.13643402
95MP0000432_abnormal_head_morphology1.12284244
96MP0010352_gastrointestinal_tract_polyps1.11816221
97MP0003959_abnormal_lean_body1.11712976
98MP0000003_abnormal_adipose_tissue1.10342359
99MP0003755_abnormal_palate_morphology1.09533682
100MP0002118_abnormal_lipid_homeostasis1.08843770
101MP0000049_abnormal_middle_ear1.07219660
102MP0005174_abnormal_tail_pigmentation1.07193375
103MP0001879_abnormal_lymphatic_vessel1.05260956
104MP0005164_abnormal_response_to1.04511208
105MP0003699_abnormal_female_reproductive1.02421423
106MP0009672_abnormal_birth_weight1.02283277
107MP0010329_abnormal_lipoprotein_level1.02200628
108MP0006138_congestive_heart_failure1.00536441
109MP0004957_abnormal_blastocyst_morpholog0.99979943
110MP0005395_other_phenotype0.99597491
111MP0002086_abnormal_extraembryonic_tissu0.99145238
112MP0001533_abnormal_skeleton_physiology0.97282992
113MP0002116_abnormal_craniofacial_bone0.97253787
114MP0000465_gastrointestinal_hemorrhage0.97177986
115MP0004130_abnormal_muscle_cell0.96381089
116MP0005535_abnormal_body_temperature0.95967312
117MP0002928_abnormal_bile_duct0.93492467
118MP0001853_heart_inflammation0.93428890
119MP0000639_abnormal_adrenal_gland0.92990578
120MP0003122_maternal_imprinting0.92481662
121MP0001697_abnormal_embryo_size0.91944830
122MP0002233_abnormal_nose_morphology0.90552235
123MP0005248_abnormal_Harderian_gland0.90260261
124MP0009785_altered_susceptibility_to0.90208515
125MP0003690_abnormal_glial_cell0.90204746
126MP0003183_abnormal_peptide_metabolism0.89709340
127MP0000733_abnormal_muscle_development0.89032084
128MP0002166_altered_tumor_susceptibility0.88529393
129MP0001944_abnormal_pancreas_morphology0.87994840
130MP0005000_abnormal_immune_tolerance0.86670378
131MP0003935_abnormal_craniofacial_develop0.86586942
132MP0000609_abnormal_liver_physiology0.85918972
133MP0003195_calcinosis0.85543389
134MP0010030_abnormal_orbit_morphology0.85103300
135MP0002210_abnormal_sex_determination0.84801097
136MP0003941_abnormal_skin_development0.84120689
137MP0005076_abnormal_cell_differentiation0.83908149
138MP0009278_abnormal_bone_marrow0.83667167
139MP0005220_abnormal_exocrine_pancreas0.83565809
140MP0005275_abnormal_skin_tensile0.82100016
141MP0002102_abnormal_ear_morphology0.82035816
142MP0003705_abnormal_hypodermis_morpholog0.81328155
143MP0005025_abnormal_response_to0.81302873
144MP0003698_abnormal_male_reproductive0.81271515
145MP0002148_abnormal_hypersensitivity_rea0.79772531
146MP0000537_abnormal_urethra_morphology0.79716815
147MP0002925_abnormal_cardiovascular_devel0.79365702
148MP0005319_abnormal_enzyme/_coenzyme0.79255069
149MP0001790_abnormal_immune_system0.79168051
150MP0005387_immune_system_phenotype0.79168051
151MP0005645_abnormal_hypothalamus_physiol0.78429555
152MP0001286_abnormal_eye_development0.77867949
153MP0002452_abnormal_antigen_presenting0.77129129
154MP0003890_abnormal_embryonic-extraembry0.76850811
155MP0010368_abnormal_lymphatic_system0.76302090
156MP0002127_abnormal_cardiovascular_syste0.75490122
157MP0001119_abnormal_female_reproductive0.73341669
158MP0003385_abnormal_body_wall0.72650452
159MP0005085_abnormal_gallbladder_physiolo0.72301559
160MP0005375_adipose_tissue_phenotype0.72043684
161MP0002723_abnormal_immune_serum0.71819916
162MP0002109_abnormal_limb_morphology0.71519284
163MP0008961_abnormal_basal_metabolism0.71050927
164MP0001145_abnormal_male_reproductive0.69756777
165MP0000462_abnormal_digestive_system0.69450026
166MP0002161_abnormal_fertility/fecundity0.68986870
167MP0010678_abnormal_skin_adnexa0.68889819
168MP0003828_pulmonary_edema0.67396707
169MP0009703_decreased_birth_body0.66908713
170MP0003252_abnormal_bile_duct0.64900136
171MP0001293_anophthalmia0.64628490
172MP0002970_abnormal_white_adipose0.62074482
173MP0000266_abnormal_heart_morphology0.60884379
174MP0000377_abnormal_hair_follicle0.59809147
175MP0004197_abnormal_fetal_growth/weight/0.59617188
176MP0002113_abnormal_skeleton_development0.59592158
177MP0000653_abnormal_sex_gland0.58911583
178MP0003938_abnormal_ear_development0.58868520
179MP0002114_abnormal_axial_skeleton0.58623310

Predicted human phenotypes

RankGene SetZ-score
1Large eyes (HP:0001090)5.29781836
2Small epiphyses (HP:0010585)4.57454202
3Vertebral arch anomaly (HP:0008438)4.46807069
4Abnormality of the intervertebral disk (HP:0005108)4.41034753
5Pendular nystagmus (HP:0012043)3.99279010
6Recurrent gram-negative bacterial infections (HP:0005420)3.96158626
7Abnormality of macrophages (HP:0004311)3.93028742
8Malnutrition (HP:0004395)3.91477070
9Mitral stenosis (HP:0001718)3.77569899
10Impulsivity (HP:0100710)3.58888089
11Papillary thyroid carcinoma (HP:0002895)3.56776353
12Ectopic kidney (HP:0000086)3.52929348
13Ulnar bowing (HP:0003031)3.47548631
14Lip pit (HP:0100267)3.44985455
15Hyperglycemia (HP:0003074)3.40858224
16Shawl scrotum (HP:0000049)3.39331455
17Amyloidosis (HP:0011034)3.34369556
18Prolonged bleeding time (HP:0003010)3.30665040
19Abnormality of liposaccharide metabolism (HP:0010968)3.28863276
20Abnormality of glycosphingolipid metabolism (HP:0004343)3.28863276
21Abnormality of glycolipid metabolism (HP:0010969)3.28863276
22Hypophosphatemic rickets (HP:0004912)3.28796003
23Hypoplasia of the capital femoral epiphysis (HP:0003090)3.28456220
24Abnormality of the fingertips (HP:0001211)3.27158195
25Systemic lupus erythematosus (HP:0002725)3.23000274
26Dysostosis multiplex (HP:0000943)3.22351340
27Stomatitis (HP:0010280)3.21437630
28Prostate neoplasm (HP:0100787)3.20319055
29Loss of speech (HP:0002371)3.19932365
30Volvulus (HP:0002580)3.19781156
31Genu recurvatum (HP:0002816)3.15454030
32Eczematoid dermatitis (HP:0000976)3.05136556
33Facial hemangioma (HP:0000329)2.98927498
34Truncal obesity (HP:0001956)2.98073688
35Unilateral renal agenesis (HP:0000122)2.96943613
36Asymmetric septal hypertrophy (HP:0001670)2.95931272
37Gingival bleeding (HP:0000225)2.94746523
38Abnormality of aromatic amino acid family metabolism (HP:0004338)2.89924740
39Arthropathy (HP:0003040)2.89164546
40Barrel-shaped chest (HP:0001552)2.87854708
41Complement deficiency (HP:0004431)2.86422417
42Adrenal hypoplasia (HP:0000835)2.85120111
43Oligodontia (HP:0000677)2.82085786
44Abnormality of mucopolysaccharide metabolism (HP:0011020)2.81738955
45Abnormality of polysaccharide metabolism (HP:0011012)2.81738955
46Abnormality of glycosaminoglycan metabolism (HP:0004371)2.81738955
47Patellar aplasia (HP:0006443)2.80192033
48Mucopolysacchariduria (HP:0008155)2.74542732
49Urinary glycosaminoglycan excretion (HP:0003541)2.74542732
50Myocardial infarction (HP:0001658)2.73521113
51Hyperlipoproteinemia (HP:0010980)2.72537566
52Hypercortisolism (HP:0001578)2.70452832
53Episodic fever (HP:0001954)2.68556457
54Abnormality of monocarboxylic acid metabolism (HP:0010996)2.66764102
55Recurrent bacterial skin infections (HP:0005406)2.65823471
56Rickets (HP:0002748)2.63496797
57Chromsome breakage (HP:0040012)2.60420806
58Limited hip movement (HP:0008800)2.59710638
59Subcapsular cataract (HP:0000523)2.59518905
60Flattened epiphyses (HP:0003071)2.57265524
61Recurrent abscess formation (HP:0002722)2.57024046
62Congenital sensorineural hearing impairment (HP:0008527)2.53711871
63Abnormality of the labia minora (HP:0012880)2.52239201
64Purpura (HP:0000979)2.51993991
65Aplasia/Hypoplasia of the patella (HP:0006498)2.51953925
66Hematochezia (HP:0002573)2.51790686
67Abnormality of the parietal bone (HP:0002696)2.49904303
68Polycythemia (HP:0001901)2.49798473
69Abnormality of proline metabolism (HP:0010907)2.48247657
70Hydroxyprolinuria (HP:0003080)2.48247657
71Abnormality of the common coagulation pathway (HP:0010990)2.48062367
72Azoospermia (HP:0000027)2.46096412
73Capillary hemangiomas (HP:0005306)2.45640312
74Flared metaphyses (HP:0003015)2.45481745
75Abnormal cortical bone morphology (HP:0003103)2.43862381
76Vertebral clefting (HP:0008428)2.43550735
77Tetraparesis (HP:0002273)2.42975894
78Tibial bowing (HP:0002982)2.42844634
79Abnormality of complement system (HP:0005339)2.41859463
80Absent epiphyses (HP:0010577)2.41455217
81Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.41455217
82Joint hemorrhage (HP:0005261)2.41113635
83Long eyelashes (HP:0000527)2.36799835
84Chromosomal breakage induced by crosslinking agents (HP:0003221)2.31755592
85Abnormality of the vasculature of the conjunctiva (HP:0008054)2.31737007
86Conjunctival telangiectasia (HP:0000524)2.31107709
87Sparse lateral eyebrow (HP:0005338)2.29764560
88Epistaxis (HP:0000421)2.25923720
89Prominent nose (HP:0000448)2.25907999
90Hypoplastic iliac wings (HP:0002866)2.25361214
91Metaphyseal dysplasia (HP:0100255)2.25265850
92Male infertility (HP:0003251)2.25150346
93Neoplasm of the oral cavity (HP:0100649)2.24318833
94Gingivitis (HP:0000230)2.23960183
95Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.23616759
96Delayed cranial suture closure (HP:0000270)2.23344472
97Spontaneous hematomas (HP:0007420)2.22439926
98Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.22394352
99Fatigue (HP:0012378)2.21881268
100Birth length less than 3rd percentile (HP:0003561)2.20643819
101Osteomalacia (HP:0002749)2.20337697
102Aseptic necrosis (HP:0010885)2.19542744
103Exocrine pancreatic insufficiency (HP:0001738)2.19071677
104Hypertriglyceridemia (HP:0002155)2.18816231
105Retrobulbar optic neuritis (HP:0100654)2.18802055
106Optic neuritis (HP:0100653)2.18802055
107Aortic regurgitation (HP:0001659)2.18309221
108Abnormality of lateral ventricle (HP:0030047)2.18192149
109Microtia (HP:0008551)2.18013545
110Limited elbow extension (HP:0001377)2.16339262
111Sparse scalp hair (HP:0002209)2.16323337
112Ependymoma (HP:0002888)2.15147714
113Menorrhagia (HP:0000132)2.13150736
114Abnormality of the diencephalon (HP:0010662)2.12966181
115Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.11354114
116Abnormality of the aortic arch (HP:0012303)2.10353931
117Petechiae (HP:0000967)2.09476996
118Short femoral neck (HP:0100864)2.08643534
119Deep venous thrombosis (HP:0002625)2.08621911
120Rectal prolapse (HP:0002035)2.08581429
121Hemivertebrae (HP:0002937)2.07951546
122Spina bifida occulta (HP:0003298)2.07880106
123Abnormality of the tricuspid valve (HP:0001702)2.05419415
124Cone-rod dystrophy (HP:0000548)2.04953791
125Prolonged partial thromboplastin time (HP:0003645)2.04560953
126Hypercholesterolemia (HP:0003124)2.03969719
127Hypoplastic ischia (HP:0003175)2.03246539
128Abnormality of the phalanges of the hallux (HP:0010057)2.02561795
129Narrow palate (HP:0000189)2.02047785
130Oligodactyly (HP:0012165)2.01914387
131Cranial hyperostosis (HP:0004437)2.01482353
132Recurrent skin infections (HP:0001581)1.99256562
133Muscle fiber splitting (HP:0003555)1.98008261
134Periodontitis (HP:0000704)1.97144337
135Albinism (HP:0001022)1.96447191
136Broad forehead (HP:0000337)1.95671191
137Midline defect of the nose (HP:0004122)1.95132836
138Delayed eruption of teeth (HP:0000684)1.94477477
139Orchitis (HP:0100796)1.94169795
140Rib fusion (HP:0000902)1.93793769
141Abnormal platelet volume (HP:0011876)1.93720040
142Increased CSF protein (HP:0002922)1.93263478
143Anhidrosis (HP:0000970)1.93057212
144Thickened helices (HP:0000391)1.92200139
145Cystic liver disease (HP:0006706)1.91725689
146Insulin-resistant diabetes mellitus (HP:0000831)1.90908130
147Hypophosphatemia (HP:0002148)1.90171069
148Acne (HP:0001061)1.89407449
149Abnormality of incisor morphology (HP:0011063)1.88123138
150Short philtrum (HP:0000322)1.88054201
151Breast hypoplasia (HP:0003187)1.86972007
152Steatorrhea (HP:0002570)1.86769223
153Abnormal spermatogenesis (HP:0008669)1.85890223
154Gynecomastia (HP:0000771)1.85866455
155Increased mean platelet volume (HP:0011877)1.85763150
156Abnormality of the nasal septum (HP:0000419)1.85603344
157Pigmentary retinal degeneration (HP:0001146)1.85382770
158Increased serum ferritin (HP:0003281)1.85062651
159Disinhibition (HP:0000734)1.84881524
160Irregular vertebral endplates (HP:0003301)1.84387330
161Astrocytoma (HP:0009592)1.83388886
162Abnormality of the astrocytes (HP:0100707)1.83388886
163Increased number of teeth (HP:0011069)1.82703123
164Fair hair (HP:0002286)1.81243395
165Dental malocclusion (HP:0000689)1.80951874
166Increased IgE level (HP:0003212)1.80885725
167Pathologic fracture (HP:0002756)1.80118460
168Thyroid carcinoma (HP:0002890)1.80097967
169Metaphyseal irregularity (HP:0003025)1.79764039
170Hemoptysis (HP:0002105)1.78650964
171Glomerulonephritis (HP:0000099)1.78455325
172Urethral obstruction (HP:0000796)1.77600468
173Patellar dislocation (HP:0002999)1.77480584
174Hypoplastic labia majora (HP:0000059)1.77435391
175Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.77364149
176Intrahepatic cholestasis (HP:0001406)1.75602779
177Abnormal pancreas size (HP:0012094)1.74389705
178Neoplasm of the tracheobronchial system (HP:0100552)1.74032061
179Myositis (HP:0100614)1.73814260
180Bowed forearm bones (HP:0003956)1.73695538
181Bowing of the arm (HP:0006488)1.73695538
182Abnormality of the epiphysis of the femoral head (HP:0010574)1.72512952
183Abnormality of calcium-phosphate metabolism (HP:0100530)1.71863618
184Cutaneous melanoma (HP:0012056)1.71737347
185Highly arched eyebrow (HP:0002553)1.71074056
186Keratoconjunctivitis sicca (HP:0001097)1.71034860
187Atrioventricular block (HP:0001678)1.69557170
188Breast aplasia (HP:0100783)1.69157197
189Abnormality of the ischium (HP:0003174)1.68628079
190Hypoalphalipoproteinemia (HP:0003233)1.65846469
191Acute myeloid leukemia (HP:0004808)1.65218185

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.85962632
2CDK85.29240361
3LATS14.43859539
4CDC73.91809592
5MAP3K133.17191609
6LATS22.88379556
7TAOK12.76755476
8MAP3K92.76324824
9PRPF4B2.73734927
10STK38L2.53483067
11DMPK2.47332954
12CAMK1D2.41136046
13CHEK22.27084025
14ERBB42.21621258
15CDK72.13680352
16KSR22.10088706
17STK32.06400838
18NEK22.02131716
19PLK41.99096775
20BMPR21.96517357
21MAP3K61.83465402
22IRAK11.83118619
23PNCK1.81906204
24RIPK41.79944596
25CAMK1G1.77808446
26BLK1.77545861
27MAP3K141.77202561
28TYK21.73605166
29MAP2K31.72473026
30MAP3K31.70470329
31MOS1.63882319
32TAOK31.59451137
33INSRR1.55162653
34EPHB21.54096687
35SIK31.50396782
36NUAK11.47237686
37ZAP701.46249685
38MAPK111.45883810
39PIK3CG1.43812551
40YES11.42137946
41MTOR1.39357454
42NEK61.38040486
43MAP3K21.34217959
44TRPM71.33878236
45SIK21.33536696
46FGFR31.32714335
47ARAF1.31634992
48MAPK71.28658306
49MAP3K11.27252631
50MAPK151.26114187
51BRSK11.23240302
52SIK11.12453490
53NLK1.12397433
54MARK21.09897067
55MAPK121.08258492
56IKBKB1.07088975
57CHEK11.05471970
58CSF1R1.05126671
59STK101.03433373
60MARK31.02904694
61LMTK21.01762352
62STK381.00691068
63WNK11.00026244
64TTK0.99931893
65AURKB0.99697767
66CSK0.99294568
67SRPK10.93676532
68BRSK20.93167067
69CSNK1E0.92997868
70TBK10.92727596
71IRAK40.92474576
72PAK60.90185829
73MAPK100.89830154
74PRKD20.88585750
75IRAK20.87744154
76CDK20.86893849
77MATK0.85549225
78PDK10.84962744
79MELK0.83381837
80ATM0.83175176
81PDPK10.81292574
82IKBKE0.81182189
83FGR0.79865553
84MAPK140.79528440
85KIT0.76591674
86TIE10.76515305
87IRAK30.75243781
88PAK20.74865736
89DDR20.74393792
90AKT20.72986749
91JAK10.72467999
92RPS6KA40.72160875
93EPHB10.71953849
94FES0.69905475
95RET0.69059636
96ATR0.68299573
97ICK0.67828658
98SGK30.67624746
99JAK20.67531680
100MAPKAPK20.65600080
101CDK10.64497041
102MAP3K70.64085256
103SGK20.62551626
104CDK30.62132237
105RAF10.60906351
106BRAF0.60255876
107CAMK40.60048599
108PRKACB0.59188371
109CDK40.58961388
110GSK3A0.58487616
111FER0.57621499
112PRKAA10.57291715
113TGFBR20.57085997
114GRK70.56922267
115CDK90.56490357
116PRKAA20.56017276
117CDK190.55345572
118RPS6KA10.55043102
119VRK10.54908616
120GSK3B0.54844591
121HCK0.52536156
122JAK30.51773552
123TAOK20.49734927
124CSNK1D0.45693429
125PDGFRB0.45372309
126PIM10.45358072
127CDK60.45298787
128TNK20.45068706
129PLK10.44923039
130MAPK30.44783596
131NTRK30.44264643
132TYRO30.43316238
133PRKG10.42149057
134RPS6KA30.39704468
135PAK40.39586939
136PDGFRA0.38765091
137MAP3K40.37629072
138ACVR1B0.37057086
139STK240.36317913
140BRD40.36211978
141CHUK0.35718603
142PAK30.35547782
143AKT30.35297440
144PLK30.34295811
145AKT10.33705286
146WNK30.33303213
147CSNK1A10.33184198
148MAPK130.32240883
149NTRK20.31722173
150TRIB30.29572636
151EEF2K0.28573199
152RPS6KA50.27516272
153ILK0.25967921
154ABL10.25693153
155PRKD10.24992375
156MAPK10.24264584
157PLK20.24246943
158KSR10.23336371
159CDC42BPA0.21173838
160PRKD30.21131100
161MAPK80.20549054
162NEK10.19996336
163CSNK2A20.18652753
164MUSK0.18539318

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030225.51010930
2Cell cycle_Homo sapiens_hsa041102.25756863
3Pancreatic cancer_Homo sapiens_hsa052122.24502869
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.19389463
5Complement and coagulation cascades_Homo sapiens_hsa046102.14452655
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.04593902
7Staphylococcus aureus infection_Homo sapiens_hsa051502.02854447
8Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.96931706
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.77854788
10Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.77676224
11MicroRNAs in cancer_Homo sapiens_hsa052061.77133363
12Small cell lung cancer_Homo sapiens_hsa052221.76689316
13Prolactin signaling pathway_Homo sapiens_hsa049171.76332764
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75231157
15Chronic myeloid leukemia_Homo sapiens_hsa052201.73596944
16Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.69816754
17Spliceosome_Homo sapiens_hsa030401.69450381
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.68720536
19Renal cell carcinoma_Homo sapiens_hsa052111.68579529
20Lysine degradation_Homo sapiens_hsa003101.66747109
21Colorectal cancer_Homo sapiens_hsa052101.63159830
22Non-small cell lung cancer_Homo sapiens_hsa052231.62349749
23Notch signaling pathway_Homo sapiens_hsa043301.56807189
24RNA transport_Homo sapiens_hsa030131.55299929
25Legionellosis_Homo sapiens_hsa051341.52569154
26Melanoma_Homo sapiens_hsa052181.51862151
27Leishmaniasis_Homo sapiens_hsa051401.51295021
28mTOR signaling pathway_Homo sapiens_hsa041501.51057392
29Prostate cancer_Homo sapiens_hsa052151.49942973
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.49755653
31Adherens junction_Homo sapiens_hsa045201.49047552
32RNA degradation_Homo sapiens_hsa030181.48542847
33Herpes simplex infection_Homo sapiens_hsa051681.48167151
34mRNA surveillance pathway_Homo sapiens_hsa030151.41667442
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.39397468
36Lysosome_Homo sapiens_hsa041421.39074107
37Regulation of autophagy_Homo sapiens_hsa041401.38693931
38Pertussis_Homo sapiens_hsa051331.35278527
39Endometrial cancer_Homo sapiens_hsa052131.34655411
40Malaria_Homo sapiens_hsa051441.32952784
41Homologous recombination_Homo sapiens_hsa034401.26905625
42Viral carcinogenesis_Homo sapiens_hsa052031.24411888
43Longevity regulating pathway - mammal_Homo sapiens_hsa042111.21365510
44Tuberculosis_Homo sapiens_hsa051521.20496548
45Inositol phosphate metabolism_Homo sapiens_hsa005621.19320503
46Phagosome_Homo sapiens_hsa041451.18376350
47Glioma_Homo sapiens_hsa052141.18296376
48Type II diabetes mellitus_Homo sapiens_hsa049301.18053093
49Chemokine signaling pathway_Homo sapiens_hsa040621.17648701
50p53 signaling pathway_Homo sapiens_hsa041151.16131476
51Other glycan degradation_Homo sapiens_hsa005111.14591037
52Systemic lupus erythematosus_Homo sapiens_hsa053221.13797951
53Adipocytokine signaling pathway_Homo sapiens_hsa049201.12257593
54Carbohydrate digestion and absorption_Homo sapiens_hsa049731.09595515
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07279139
56TGF-beta signaling pathway_Homo sapiens_hsa043501.06428980
57Hippo signaling pathway_Homo sapiens_hsa043901.04384867
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03476776
59Basal cell carcinoma_Homo sapiens_hsa052171.00329041
60Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00135428
61HTLV-I infection_Homo sapiens_hsa051660.99716896
62Fanconi anemia pathway_Homo sapiens_hsa034600.98726765
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97165944
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95838556
65Wnt signaling pathway_Homo sapiens_hsa043100.95665608
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93975160
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93588468
68Thyroid cancer_Homo sapiens_hsa052160.93564094
69Hepatitis B_Homo sapiens_hsa051610.90510848
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89714651
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89350952
72FoxO signaling pathway_Homo sapiens_hsa040680.89236198
73Circadian rhythm_Homo sapiens_hsa047100.88777133
74Insulin resistance_Homo sapiens_hsa049310.88117367
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88039530
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.86596321
77Bladder cancer_Homo sapiens_hsa052190.85966209
78GnRH signaling pathway_Homo sapiens_hsa049120.85951601
79Choline metabolism in cancer_Homo sapiens_hsa052310.84312788
80PPAR signaling pathway_Homo sapiens_hsa033200.83876916
81Pathways in cancer_Homo sapiens_hsa052000.82307789
82Shigellosis_Homo sapiens_hsa051310.79928577
83Acute myeloid leukemia_Homo sapiens_hsa052210.79542292
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79313299
85ErbB signaling pathway_Homo sapiens_hsa040120.74066680
86ABC transporters_Homo sapiens_hsa020100.73874090
87Prion diseases_Homo sapiens_hsa050200.73345826
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72955755
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.71878339
90VEGF signaling pathway_Homo sapiens_hsa043700.70898573
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.70436929
92MAPK signaling pathway_Homo sapiens_hsa040100.69112678
93Caffeine metabolism_Homo sapiens_hsa002320.67772598
94TNF signaling pathway_Homo sapiens_hsa046680.67587543
95Platelet activation_Homo sapiens_hsa046110.67467364
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67182706
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.66416265
98Hematopoietic cell lineage_Homo sapiens_hsa046400.65961373
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65483494
100Glycerolipid metabolism_Homo sapiens_hsa005610.65385285
101Proteoglycans in cancer_Homo sapiens_hsa052050.64954735
102Rheumatoid arthritis_Homo sapiens_hsa053230.64780590
103cAMP signaling pathway_Homo sapiens_hsa040240.64590650
104Estrogen signaling pathway_Homo sapiens_hsa049150.63011570
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62600623
106Osteoclast differentiation_Homo sapiens_hsa043800.62516570
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62282007
108Fatty acid biosynthesis_Homo sapiens_hsa000610.61511291
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61223271
110Endocytosis_Homo sapiens_hsa041440.59908473
111HIF-1 signaling pathway_Homo sapiens_hsa040660.59515395
112Ras signaling pathway_Homo sapiens_hsa040140.59510577
113Dorso-ventral axis formation_Homo sapiens_hsa043200.58814812
114Rap1 signaling pathway_Homo sapiens_hsa040150.57975079
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57041060
116Ovarian steroidogenesis_Homo sapiens_hsa049130.56648018
117Gap junction_Homo sapiens_hsa045400.56594255
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56467763
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54349961
120Focal adhesion_Homo sapiens_hsa045100.52996786
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52158189
122Influenza A_Homo sapiens_hsa051640.51177313
123Toxoplasmosis_Homo sapiens_hsa051450.49267109
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49007398
125RNA polymerase_Homo sapiens_hsa030200.48323364
126Amoebiasis_Homo sapiens_hsa051460.47509916
127Tight junction_Homo sapiens_hsa045300.46735335
128AMPK signaling pathway_Homo sapiens_hsa041520.46534726
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.45413102
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44801592
131Axon guidance_Homo sapiens_hsa043600.43703071
132B cell receptor signaling pathway_Homo sapiens_hsa046620.43502270
133Type I diabetes mellitus_Homo sapiens_hsa049400.43181648
134Insulin signaling pathway_Homo sapiens_hsa049100.40276737
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.39732125
136T cell receptor signaling pathway_Homo sapiens_hsa046600.39444133
137Mismatch repair_Homo sapiens_hsa034300.39361687
138Alcoholism_Homo sapiens_hsa050340.36767484
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36300436
140Glucagon signaling pathway_Homo sapiens_hsa049220.35042060
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.34874657
142Measles_Homo sapiens_hsa051620.33378988
143Apoptosis_Homo sapiens_hsa042100.32657025
144PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32349867
145Hedgehog signaling pathway_Homo sapiens_hsa043400.30799803

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