KLF12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.89495402
2activated T cell proliferation (GO:0050798)4.86698225
3establishment of nucleus localization (GO:0040023)4.61315398
4histone H3-K4 trimethylation (GO:0080182)4.52335285
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.41910069
6L-phenylalanine catabolic process (GO:0006559)4.26037090
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.26037090
8phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.24248017
9alpha-linolenic acid metabolic process (GO:0036109)4.21785671
10negative T cell selection (GO:0043383)4.18066111
11cell communication by electrical coupling (GO:0010644)4.16929891
12dicarboxylic acid biosynthetic process (GO:0043650)4.15850850
13kynurenine metabolic process (GO:0070189)4.00470915
14aromatic amino acid family catabolic process (GO:0009074)3.97669175
15L-phenylalanine metabolic process (GO:0006558)3.96207354
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.96207354
17neural tube formation (GO:0001841)3.93103399
18tryptophan catabolic process (GO:0006569)3.81065636
19indole-containing compound catabolic process (GO:0042436)3.81065636
20indolalkylamine catabolic process (GO:0046218)3.81065636
21nucleobase catabolic process (GO:0046113)3.79711082
22high-density lipoprotein particle remodeling (GO:0034375)3.79604445
23presynaptic membrane assembly (GO:0097105)3.78229085
24bile acid biosynthetic process (GO:0006699)3.77071869
25negative thymic T cell selection (GO:0045060)3.76115136
26negative regulation of cAMP-mediated signaling (GO:0043951)3.75819435
27nucleus localization (GO:0051647)3.70823532
28positive T cell selection (GO:0043368)3.68341669
29amino-acid betaine metabolic process (GO:0006577)3.62449084
30reverse cholesterol transport (GO:0043691)3.57169277
31regulation of bile acid biosynthetic process (GO:0070857)3.55525169
32tryptophan metabolic process (GO:0006568)3.52768549
33glyoxylate metabolic process (GO:0046487)3.50404016
34purine nucleotide transport (GO:0015865)3.49807422
35neurotransmitter-gated ion channel clustering (GO:0072578)3.49351880
36serine family amino acid catabolic process (GO:0009071)3.49202749
37presynaptic membrane organization (GO:0097090)3.49192209
38lysine metabolic process (GO:0006553)3.46228216
39lysine catabolic process (GO:0006554)3.46228216
40negative regulation of fibrinolysis (GO:0051918)3.45594786
41negative regulation of cell killing (GO:0031342)3.45181085
42negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.45181085
43glutamate metabolic process (GO:0006536)3.43670057
44urea cycle (GO:0000050)3.41092455
45urea metabolic process (GO:0019627)3.41092455
46cerebral cortex radially oriented cell migration (GO:0021799)3.39709597
47bile acid metabolic process (GO:0008206)3.38512137
48coenzyme catabolic process (GO:0009109)3.31780601
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.31469100
50protein-lipid complex remodeling (GO:0034368)3.31243694
51macromolecular complex remodeling (GO:0034367)3.31243694
52plasma lipoprotein particle remodeling (GO:0034369)3.31243694
53adenine nucleotide transport (GO:0051503)3.30616591
54forebrain neuron differentiation (GO:0021879)3.30411265
55regulation of protein activation cascade (GO:2000257)3.28330071
56sulfur amino acid catabolic process (GO:0000098)3.27610829
57alpha-amino acid catabolic process (GO:1901606)3.26977467
58regulation of fibrinolysis (GO:0051917)3.26858552
59cellular modified amino acid catabolic process (GO:0042219)3.26170287
60monoubiquitinated protein deubiquitination (GO:0035520)3.25825785
61positive regulation of fatty acid beta-oxidation (GO:0032000)3.24130754
62postsynaptic membrane organization (GO:0001941)3.23227362
63sodium ion export (GO:0071436)3.22297540
64cysteine metabolic process (GO:0006534)3.21257756
65atrial cardiac muscle cell action potential (GO:0086014)3.20234758
66homocysteine metabolic process (GO:0050667)3.19008401
67peptidyl-lysine trimethylation (GO:0018023)3.16795532
68carnitine metabolic process (GO:0009437)3.15700984
69response to pheromone (GO:0019236)3.12383279
70negative regulation of astrocyte differentiation (GO:0048712)3.11906584
71central nervous system neuron axonogenesis (GO:0021955)3.11367524
72purine ribonucleotide transport (GO:0015868)3.11209967
73low-density lipoprotein particle remodeling (GO:0034374)3.10172588
74fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.09719162
75aspartate family amino acid catabolic process (GO:0009068)3.08639986
76peptidyl-glutamic acid carboxylation (GO:0017187)3.08395882
77protein carboxylation (GO:0018214)3.08395882
78dicarboxylic acid catabolic process (GO:0043649)3.07750867
79negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.04424827
80ethanol oxidation (GO:0006069)3.03545863
81gap junction assembly (GO:0016264)3.03423878
82limb bud formation (GO:0060174)3.03185650
83complement activation, alternative pathway (GO:0006957)3.02862469
84regulation of complement activation (GO:0030449)3.02454130
85cellular amino acid catabolic process (GO:0009063)3.02220501
86cellular ketone body metabolic process (GO:0046950)3.01686430
87neuron recognition (GO:0008038)3.00250919
88regulation of B cell receptor signaling pathway (GO:0050855)3.00045686
89protein localization to synapse (GO:0035418)2.99726623
90regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.98288814
91retinal ganglion cell axon guidance (GO:0031290)2.97403531
92cardiac ventricle formation (GO:0003211)2.95881455
93interferon-gamma production (GO:0032609)2.95764524
94cardiac chamber formation (GO:0003207)2.95414967
95nitrogen cycle metabolic process (GO:0071941)2.95076846
96vocalization behavior (GO:0071625)2.94325900
97cerebellar Purkinje cell differentiation (GO:0021702)2.92981117
98triglyceride homeostasis (GO:0070328)2.90631574
99acylglycerol homeostasis (GO:0055090)2.90631574
100regulation of short-term neuronal synaptic plasticity (GO:0048172)2.90614300
101negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.90442081
102negative regulation of translation, ncRNA-mediated (GO:0040033)2.90442081
103regulation of translation, ncRNA-mediated (GO:0045974)2.90442081
104axonal fasciculation (GO:0007413)2.88900158
105establishment of protein localization to Golgi (GO:0072600)2.88448022
106cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.87774457
107regulation of timing of cell differentiation (GO:0048505)2.87179640
108regulation of fatty acid beta-oxidation (GO:0031998)2.85173623
109negative regulation of cholesterol transport (GO:0032375)2.84596945
110negative regulation of sterol transport (GO:0032372)2.84596945
111linoleic acid metabolic process (GO:0043651)2.83839473
112cellular potassium ion homeostasis (GO:0030007)2.83142746
113positive regulation of gamma-delta T cell activation (GO:0046645)2.82019566
114somite development (GO:0061053)2.81280331
115cholesterol efflux (GO:0033344)2.80760619
116positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.79605244
117cellular response to interleukin-15 (GO:0071350)2.79462094
118regulation of development, heterochronic (GO:0040034)2.79371031
119T cell selection (GO:0045058)2.79322427
120negative regulation of neurotransmitter secretion (GO:0046929)2.78191037
121histone mRNA catabolic process (GO:0071044)2.76908899
122cAMP catabolic process (GO:0006198)2.76113347
123detection of light stimulus involved in visual perception (GO:0050908)2.74291923
124detection of light stimulus involved in sensory perception (GO:0050962)2.74291923
125short-chain fatty acid metabolic process (GO:0046459)2.73149946
126indolalkylamine metabolic process (GO:0006586)2.72208914
127regulation of cholesterol esterification (GO:0010872)2.71882362
128central nervous system projection neuron axonogenesis (GO:0021952)2.71794289
129amine catabolic process (GO:0009310)2.71515247
130cellular biogenic amine catabolic process (GO:0042402)2.71515247
131cytoplasmic mRNA processing body assembly (GO:0033962)2.70573800
132aromatic amino acid family metabolic process (GO:0009072)2.70472443
133calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.68951341
134olfactory bulb development (GO:0021772)2.68329426
135head development (GO:0060322)2.68048667
136regulation of NFAT protein import into nucleus (GO:0051532)2.66382273
137regulation of cholesterol homeostasis (GO:2000188)2.66217276
138positive regulation of glycogen metabolic process (GO:0070875)2.65545619
139protein targeting to Golgi (GO:0000042)2.65356600
140embryonic retina morphogenesis in camera-type eye (GO:0060059)2.65123674
141acetyl-CoA metabolic process (GO:0006084)2.64916325
142bile acid and bile salt transport (GO:0015721)2.64578081
143positive regulation of granulocyte differentiation (GO:0030854)2.64458878
1442-oxoglutarate metabolic process (GO:0006103)2.64139429
145regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.63740604
146response to interleukin-15 (GO:0070672)2.63510738
147regulation of isotype switching to IgG isotypes (GO:0048302)2.63265348
148dendrite morphogenesis (GO:0048813)2.62902089
149cellular sodium ion homeostasis (GO:0006883)2.62459471
150dendritic spine morphogenesis (GO:0060997)2.62034326
151interkinetic nuclear migration (GO:0022027)2.61620751
152neuronal stem cell maintenance (GO:0097150)2.60977665
153phospholipid efflux (GO:0033700)2.60451498
154neuron cell-cell adhesion (GO:0007158)2.60374793
155gamma-aminobutyric acid transport (GO:0015812)2.60016330
156positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.58275956
157regulation of triglyceride catabolic process (GO:0010896)2.56140175
158retrograde transport, vesicle recycling within Golgi (GO:0000301)2.55959210
159negative regulation of neurotransmitter transport (GO:0051589)2.51624863
160cyclic nucleotide catabolic process (GO:0009214)2.48752901
161ionotropic glutamate receptor signaling pathway (GO:0035235)2.48238031
162auditory behavior (GO:0031223)2.48224976
163negative regulation of potassium ion transmembrane transport (GO:1901380)2.44353516
164peptidyl-lysine methylation (GO:0018022)2.43830723
165protein K11-linked deubiquitination (GO:0035871)2.43290321
166regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.41082457
167retina layer formation (GO:0010842)2.40832786
168tachykinin receptor signaling pathway (GO:0007217)2.40562810
169regulation of skeletal muscle cell differentiation (GO:2001014)2.40433767
170epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.40099509
171histone lysine methylation (GO:0034968)2.39439452
172Golgi to endosome transport (GO:0006895)2.37160889
173histone H3-K9 modification (GO:0061647)2.36551677
174histone H3-K4 methylation (GO:0051568)2.35636138
175transmission of nerve impulse (GO:0019226)2.34984840
176regulation of glial cell proliferation (GO:0060251)2.34492510
177centrosome localization (GO:0051642)2.30144465
178histone H4-K16 acetylation (GO:0043984)2.30089003
179T cell migration (GO:0072678)2.29331866
180negative regulation of T cell mediated immunity (GO:0002710)2.26961297
181alpha-beta T cell differentiation (GO:0046632)2.26082220
182heart valve formation (GO:0003188)2.25994353
183synapse assembly (GO:0007416)2.24048570
184positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.22539098
185mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.22539098
186heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.21966031
187thymic T cell selection (GO:0045061)2.21427752
188cell migration in hindbrain (GO:0021535)2.19496068
189regulation of gamma-delta T cell differentiation (GO:0045586)2.18548057
190regulation of relaxation of muscle (GO:1901077)2.17839124
191negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.17305779
192regulation of sarcomere organization (GO:0060297)2.16203017

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.26630353
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.96006326
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.65262874
4EZH2_22144423_ChIP-Seq_EOC_Human3.21748345
5GBX2_23144817_ChIP-Seq_PC3_Human3.17718910
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.01738050
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.98680405
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.98322065
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.77581584
10* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.51527402
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.50819048
12* LXR_22158963_ChIP-Seq_LIVER_Mouse2.39214947
13* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.38298143
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.37240608
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.24390188
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.20359085
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.19821265
18DROSHA_22980978_ChIP-Seq_HELA_Human2.17802522
19* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.13802445
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.12312750
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.11281000
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.99798050
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.99349854
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.98876962
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.98876962
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.93844260
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91652962
28* SMAD_19615063_ChIP-ChIP_OVARY_Human1.91622565
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87184705
30REST_21632747_ChIP-Seq_MESCs_Mouse1.83161512
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.83017304
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75416220
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75401764
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.74226882
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.74027852
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.73854471
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71709388
38* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70366213
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.68775049
40* FUS_26573619_Chip-Seq_HEK293_Human1.67600660
41* RUNX_20019798_ChIP-Seq_JUKART_Human1.66492186
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64359875
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63574266
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60353927
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60012611
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56045554
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.54028290
48EWS_26573619_Chip-Seq_HEK293_Human1.52983463
49AR_21572438_ChIP-Seq_LNCaP_Human1.52846071
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.52630870
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52406925
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.51999096
53REST_18959480_ChIP-ChIP_MESCs_Mouse1.51983716
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51149761
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48730714
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47096006
57* PIAS1_25552417_ChIP-Seq_VCAP_Human1.44000297
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42743569
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41292771
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.38004950
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.37234497
62TAF15_26573619_Chip-Seq_HEK293_Human1.37109906
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36471204
64RARB_27405468_Chip-Seq_BRAIN_Mouse1.35077694
65STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32218053
66* SOX2_21211035_ChIP-Seq_LN229_Gbm1.31622287
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31272284
68* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28930542
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28906733
70SMAD4_21799915_ChIP-Seq_A2780_Human1.28629744
71ER_23166858_ChIP-Seq_MCF-7_Human1.28278291
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.27381655
73* AR_19668381_ChIP-Seq_PC3_Human1.27079374
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26705207
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26372177
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25744543
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.25713080
78* KDM2B_26808549_Chip-Seq_REH_Human1.25556146
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24326267
80ZNF274_21170338_ChIP-Seq_K562_Hela1.24031245
81P300_19829295_ChIP-Seq_ESCs_Human1.22015876
82* AR_25329375_ChIP-Seq_VCAP_Human1.21728680
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.21404596
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19593449
85TP53_16413492_ChIP-PET_HCT116_Human1.19456441
86P53_22387025_ChIP-Seq_ESCs_Mouse1.17784905
87SMAD4_21741376_ChIP-Seq_HESCs_Human1.17655678
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.17261269
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.16395772
90* FOXA2_19822575_ChIP-Seq_HepG2_Human1.16034216
91* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15747098
92* FLI1_21867929_ChIP-Seq_TH2_Mouse1.15361656
93FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14874244
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13801741
95* PRDM14_20953172_ChIP-Seq_ESCs_Human1.12990462
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12710294
97STAT3_23295773_ChIP-Seq_U87_Human1.12459264
98TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11927144
99IGF1R_20145208_ChIP-Seq_DFB_Human1.11642198
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.11554684
101* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10000572
102CMYC_18555785_Chip-Seq_ESCs_Mouse1.09518365
103BCAT_22108803_ChIP-Seq_LS180_Human1.09482167
104TP63_19390658_ChIP-ChIP_HaCaT_Human1.08621390
105* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08327265
106* ARNT_22903824_ChIP-Seq_MCF-7_Human1.08003880
107RING1B_27294783_Chip-Seq_NPCs_Mouse1.07918319
108TCF4_18268006_ChIP-ChIP_LS174T_Human1.07323240
109OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06857112
110* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06411154
111GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06374048
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06149278
113* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05363684
114TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.04899376
115* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04880691
116* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04880691
117ERG_21242973_ChIP-ChIP_JURKAT_Human1.03852712
118* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03399377
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02508598
120ISL1_27105846_Chip-Seq_CPCs_Mouse1.02495557
121SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02363809
122* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01753681
123VDR_22108803_ChIP-Seq_LS180_Human1.00201183
124CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99152162
125CRX_20693478_ChIP-Seq_RETINA_Mouse0.99128306
126ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99041433
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98208507
128* AHR_22903824_ChIP-Seq_MCF-7_Human0.97992728
129TP53_20018659_ChIP-ChIP_R1E_Mouse0.97877201
130RNF2_27304074_Chip-Seq_NSC_Mouse0.97759384
131* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96865610
132* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96039498
133* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95941144
134DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95172487
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95157172
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95157172
137CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94003821
138* TCF4_23295773_ChIP-Seq_U87_Human0.91395512
139OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91146100
140NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91085254
141TBX3_20139965_ChIP-Seq_ESCs_Mouse0.90695990
142CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90585329
143TBX3_20139965_ChIP-Seq_MESCs_Mouse0.89151996
144* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89021679
145BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88097617
146EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86357873
147RUNX2_22187159_ChIP-Seq_PCA_Human0.86290766
148HTT_18923047_ChIP-ChIP_STHdh_Human0.85965117

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.82576046
2MP0005360_urolithiasis4.31601614
3MP0005365_abnormal_bile_salt4.20287317
4MP0005085_abnormal_gallbladder_physiolo3.99436148
5MP0003787_abnormal_imprinting3.17132181
6MP0002009_preneoplasia3.05110949
7MP0008875_abnormal_xenobiotic_pharmacok2.80026335
8MP0003252_abnormal_bile_duct2.79909880
9MP0009780_abnormal_chondrocyte_physiolo2.77244911
10MP0003763_abnormal_thymus_physiology2.68289857
11MP0003011_delayed_dark_adaptation2.63730412
12MP0008057_abnormal_DNA_replication2.61125795
13MP0005646_abnormal_pituitary_gland2.53423159
14MP0005551_abnormal_eye_electrophysiolog2.47812724
15MP0010329_abnormal_lipoprotein_level2.39210919
16MP0004859_abnormal_synaptic_plasticity2.22844109
17MP0003121_genomic_imprinting2.11940213
18MP0003880_abnormal_central_pattern2.01372155
19MP0009384_cardiac_valve_regurgitation1.99300184
20MP0005670_abnormal_white_adipose1.97888726
21MP0008877_abnormal_DNA_methylation1.96851566
22MP0000569_abnormal_digit_pigmentation1.94818693
23MP0002653_abnormal_ependyma_morphology1.85658401
24MP0000566_synostosis1.81567416
25MP0004142_abnormal_muscle_tone1.77299832
26MP0001486_abnormal_startle_reflex1.74193628
27MP0002822_catalepsy1.74074256
28MP0009840_abnormal_foam_cell1.69873267
29MP0001984_abnormal_olfaction1.64037423
30MP0009697_abnormal_copulation1.61295590
31MP0003635_abnormal_synaptic_transmissio1.59665423
32MP0010368_abnormal_lymphatic_system1.58538912
33MP0003137_abnormal_impulse_conducting1.56343617
34MP0002063_abnormal_learning/memory/cond1.56331632
35MP0002090_abnormal_vision1.49127537
36MP0001502_abnormal_circadian_rhythm1.48265869
37MP0002735_abnormal_chemical_nociception1.48233626
38MP0004215_abnormal_myocardial_fiber1.45337209
39MP0000778_abnormal_nervous_system1.42221032
40MP0003868_abnormal_feces_composition1.41575944
41MP0006276_abnormal_autonomic_nervous1.39842987
42MP0004134_abnormal_chest_morphology1.39300752
43MP0005248_abnormal_Harderian_gland1.37653906
44MP0006292_abnormal_olfactory_placode1.35801770
45MP0003183_abnormal_peptide_metabolism1.35500502
46MP0005332_abnormal_amino_acid1.33792411
47MP0002572_abnormal_emotion/affect_behav1.33082703
48MP0001440_abnormal_grooming_behavior1.26488331
49MP0002064_seizures1.26430306
50MP0004811_abnormal_neuron_physiology1.26332382
51MP0002928_abnormal_bile_duct1.25518297
52MP0009745_abnormal_behavioral_response1.23305405
53MP0010030_abnormal_orbit_morphology1.20425132
54MP0002557_abnormal_social/conspecific_i1.20102110
55MP0001529_abnormal_vocalization1.19978331
56MP0003136_yellow_coat_color1.19814309
57MP0002751_abnormal_autonomic_nervous1.19624855
58MP0001666_abnormal_nutrient_absorption1.17466883
59MP0001958_emphysema1.16769187
60MP0002118_abnormal_lipid_homeostasis1.15267560
61MP0004858_abnormal_nervous_system1.15066441
62MP0003690_abnormal_glial_cell1.14412436
63MP0008569_lethality_at_weaning1.13885373
64MP0004130_abnormal_muscle_cell1.13332946
65MP0002638_abnormal_pupillary_reflex1.12585182
66MP0003806_abnormal_nucleotide_metabolis1.12430629
67MP0005253_abnormal_eye_physiology1.11766812
68MP0004233_abnormal_muscle_weight1.11309157
69MP0005499_abnormal_olfactory_system1.10170421
70MP0005394_taste/olfaction_phenotype1.10170421
71MP0000703_abnormal_thymus_morphology1.09865924
72MP0005195_abnormal_posterior_eye1.09234034
73MP0009672_abnormal_birth_weight1.07845596
74MP0009046_muscle_twitch1.07641419
75MP0004145_abnormal_muscle_electrophysio1.07550349
76MP0001299_abnormal_eye_distance/1.06676923
77MP0003122_maternal_imprinting1.06638954
78MP0001943_abnormal_respiration1.06429901
79MP0001324_abnormal_eye_pigmentation1.04101436
80MP0008789_abnormal_olfactory_epithelium1.02102457
81MP0004019_abnormal_vitamin_homeostasis1.01903378
82MP0005083_abnormal_biliary_tract1.01756068
83MP0004484_altered_response_of1.01219894
84MP0001970_abnormal_pain_threshold1.00706362
85MP0004270_analgesia1.00612646
86MP0002876_abnormal_thyroid_physiology0.99909113
87MP0001986_abnormal_taste_sensitivity0.99395595
88MP0005647_abnormal_sex_gland0.99054007
89MP0002184_abnormal_innervation0.98837416
90MP0002127_abnormal_cardiovascular_syste0.97170630
91MP0000049_abnormal_middle_ear0.97035741
92MP0001286_abnormal_eye_development0.95192145
93MP0000631_abnormal_neuroendocrine_gland0.94834474
94MP0006072_abnormal_retinal_apoptosis0.94797580
95MP0002249_abnormal_larynx_morphology0.94455992
96MP0000609_abnormal_liver_physiology0.93679174
97MP0002089_abnormal_postnatal_growth/wei0.91983304
98MP0002733_abnormal_thermal_nociception0.91568803
99MP0005645_abnormal_hypothalamus_physiol0.90812075
100MP0004924_abnormal_behavior0.90491419
101MP0005386_behavior/neurological_phenoty0.90491419
102MP0004085_abnormal_heartbeat0.90476830
103MP0001800_abnormal_humoral_immune0.89576256
104MP0000427_abnormal_hair_cycle0.89439250
105MP0002882_abnormal_neuron_morphology0.89023681
106MP0002069_abnormal_eating/drinking_beha0.87222551
107MP0005409_darkened_coat_color0.87128513
108MP0003890_abnormal_embryonic-extraembry0.86613488
109MP0001177_atelectasis0.85530359
110MP0002067_abnormal_sensory_capabilities0.85484481
111MP0003091_abnormal_cell_migration0.83465441
112MP0000534_abnormal_ureter_morphology0.83197907
113MP0000733_abnormal_muscle_development0.83190376
114MP0002081_perinatal_lethality0.82271108
115MP0004381_abnormal_hair_follicle0.82023711
116MP0003045_fibrosis0.81685655
117MP0000428_abnormal_craniofacial_morphol0.81406606
118MP0003935_abnormal_craniofacial_develop0.81370733
119MP0002066_abnormal_motor_capabilities/c0.81084808
120MP0003879_abnormal_hair_cell0.80576141
121MP0003221_abnormal_cardiomyocyte_apopto0.79816628
122MP0002152_abnormal_brain_morphology0.79606233
123MP0003195_calcinosis0.78780310
124MP0001879_abnormal_lymphatic_vessel0.78310417
125MP0001851_eye_inflammation0.76355782
126MP0003300_gastrointestinal_ulcer0.75985505
127MP0005423_abnormal_somatic_nervous0.74329215
128MP0003705_abnormal_hypodermis_morpholog0.74174486
129MP0002163_abnormal_gland_morphology0.74038191
130MP0002109_abnormal_limb_morphology0.73324070
131MP0000955_abnormal_spinal_cord0.73277308
132MP0009053_abnormal_anal_canal0.73190916
133MP0002133_abnormal_respiratory_system0.72819857
134MP0005388_respiratory_system_phenotype0.72819857
135MP0002102_abnormal_ear_morphology0.72578607
136MP0002752_abnormal_somatic_nervous0.72559230
137MP0002272_abnormal_nervous_system0.72527701
138MP0008961_abnormal_basal_metabolism0.72445529
139MP0001501_abnormal_sleep_pattern0.72337202
140MP0005319_abnormal_enzyme/_coenzyme0.71878835
141MP0001346_abnormal_lacrimal_gland0.71398665
142MP0002734_abnormal_mechanical_nocicepti0.70353818
143MP0003279_aneurysm0.70234002
144MP0001968_abnormal_touch/_nociception0.69029529
145MP0005391_vision/eye_phenotype0.65679200
146MP0003861_abnormal_nervous_system0.64184935
147MP0005595_abnormal_vascular_smooth0.63980067
148MP0005584_abnormal_enzyme/coenzyme_acti0.62049436
149MP0000579_abnormal_nail_morphology0.61862566
150MP0001270_distended_abdomen0.61710697
151MP0005197_abnormal_uvea_morphology0.61644532
152MP0005187_abnormal_penis_morphology0.61441575

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.67509343
2Intrahepatic cholestasis (HP:0001406)4.51188434
3Hyperlipoproteinemia (HP:0010980)4.23346347
4Central scotoma (HP:0000603)3.89559338
5Hypoalphalipoproteinemia (HP:0003233)3.88554913
6Xanthomatosis (HP:0000991)3.87454595
7Congenital stationary night blindness (HP:0007642)3.69872011
8Abnormality of aromatic amino acid family metabolism (HP:0004338)3.47500226
9Hypolipoproteinemia (HP:0010981)3.38683426
10Prolonged partial thromboplastin time (HP:0003645)3.38381877
11Abnormality of monocarboxylic acid metabolism (HP:0010996)3.27462664
12Hypobetalipoproteinemia (HP:0003563)3.23679432
13Epileptic encephalopathy (HP:0200134)3.18244531
14T lymphocytopenia (HP:0005403)3.08886164
15Complement deficiency (HP:0004431)3.06547143
16Epidermoid cyst (HP:0200040)3.02582860
17Ketosis (HP:0001946)2.93856501
18Scotoma (HP:0000575)2.93491152
19Focal motor seizures (HP:0011153)2.93379492
20Aplasia involving bones of the upper limbs (HP:0009823)2.88459810
21Aplasia of the phalanges of the hand (HP:0009802)2.88459810
22Aplasia involving bones of the extremities (HP:0009825)2.88459810
23Hyperventilation (HP:0002883)2.82850740
24Abnormality of T cell number (HP:0011839)2.73582937
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.71411432
26Broad-based gait (HP:0002136)2.71191464
27Febrile seizures (HP:0002373)2.67545274
28Hyperammonemia (HP:0001987)2.65702484
29Status epilepticus (HP:0002133)2.62012439
30Abnormality of the fingertips (HP:0001211)2.58805967
31Hyperglycinemia (HP:0002154)2.57840679
32Hypoplastic iliac wings (HP:0002866)2.57562172
33Conjugated hyperbilirubinemia (HP:0002908)2.55292834
34Chorioretinal atrophy (HP:0000533)2.53530169
35Cortical dysplasia (HP:0002539)2.51224538
36Hepatoblastoma (HP:0002884)2.47112080
37Tetraparesis (HP:0002273)2.45515434
38Long clavicles (HP:0000890)2.40862166
39Amyotrophic lateral sclerosis (HP:0007354)2.40065939
40Abnormality of sulfur amino acid metabolism (HP:0004339)2.39802007
41Abnormality of glutamine family amino acid metabolism (HP:0010902)2.39767463
42Dry hair (HP:0011359)2.38323366
43Focal seizures (HP:0007359)2.35249037
44Ketoacidosis (HP:0001993)2.35108348
45Chronic hepatic failure (HP:0100626)2.34894456
46Stomach cancer (HP:0012126)2.34477791
47Volvulus (HP:0002580)2.32512844
48Abnormality of macular pigmentation (HP:0008002)2.28331485
49Cubitus valgus (HP:0002967)2.25678228
50Heterotopia (HP:0002282)2.23575237
51Tented upper lip vermilion (HP:0010804)2.23282844
52Abnormality of the intervertebral disk (HP:0005108)2.23229853
53Abnormality of salivation (HP:0100755)2.22163284
54Chin dimple (HP:0010751)2.21378405
55Broad alveolar ridges (HP:0000187)2.20908073
56Absent speech (HP:0001344)2.20518538
57Papillary thyroid carcinoma (HP:0002895)2.20436830
58EEG with generalized epileptiform discharges (HP:0011198)2.19996262
59Abnormality of the ischium (HP:0003174)2.18607648
60Nephronophthisis (HP:0000090)2.17199748
61Vitreoretinal degeneration (HP:0000655)2.16965513
62Progressive cerebellar ataxia (HP:0002073)2.16703790
63Epileptiform EEG discharges (HP:0011182)2.16587920
64Hypsarrhythmia (HP:0002521)2.16344305
65Hypoglycemic seizures (HP:0002173)2.14189531
66Deep palmar crease (HP:0006191)2.13461640
67Skin nodule (HP:0200036)2.13291405
68Narrow nasal bridge (HP:0000446)2.11226719
69Abnormality of the common coagulation pathway (HP:0010990)2.10754511
70Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.09976532
71Tracheomalacia (HP:0002779)2.08508444
72Protruding tongue (HP:0010808)2.08043153
73Lymphangioma (HP:0100764)2.07987193
74Narrow palate (HP:0000189)2.07437579
75Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.06972796
76Abnormality of incisor morphology (HP:0011063)2.06451906
77Keratoconus (HP:0000563)2.05971373
78Increased corneal curvature (HP:0100692)2.05971373
79True hermaphroditism (HP:0010459)2.05857502
80Hyperglycinuria (HP:0003108)2.05613674
81Abnormality of glycine metabolism (HP:0010895)2.04852361
82Abnormality of serine family amino acid metabolism (HP:0010894)2.04852361
83Truncal obesity (HP:0001956)2.04707720
84Absence seizures (HP:0002121)2.04334896
85Hemiplegia (HP:0002301)2.04332128
86Genetic anticipation (HP:0003743)2.02829585
87Papilledema (HP:0001085)2.02711351
88Joint hemorrhage (HP:0005261)2.01724772
89Hypochromic microcytic anemia (HP:0004840)2.01185060
90Drooling (HP:0002307)2.01166283
91Excessive salivation (HP:0003781)2.01166283
92Atrioventricular block (HP:0001678)2.00248117
93Pseudobulbar signs (HP:0002200)1.99251502
94Cystic hygroma (HP:0000476)1.98970509
95Difficulty running (HP:0009046)1.97073503
96Abnormality of the lower motor neuron (HP:0002366)1.95906700
97Fat malabsorption (HP:0002630)1.94694116
98Hypercholesterolemia (HP:0003124)1.94490224
99Widely spaced teeth (HP:0000687)1.94418210
100Vertebral arch anomaly (HP:0008438)1.94072453
101Oligodactyly (hands) (HP:0001180)1.93973399
102Severe visual impairment (HP:0001141)1.93905798
103Hypoplastic left heart (HP:0004383)1.91599887
104Diastasis recti (HP:0001540)1.90577064
105Abnormality of the intrinsic pathway (HP:0010989)1.90310378
106Abnormality of the renal medulla (HP:0100957)1.90079800
107Atonic seizures (HP:0010819)1.89453029
108Hip dysplasia (HP:0001385)1.87632478
109Abnormality of methionine metabolism (HP:0010901)1.87406628
110Mitral stenosis (HP:0001718)1.85686341
111Subaortic stenosis (HP:0001682)1.85632043
112Abnormality of the left ventricular outflow tract (HP:0011103)1.85632043
113Abnormality of the antihelix (HP:0009738)1.85323539
114Sensorimotor neuropathy (HP:0007141)1.84361858
115Severe combined immunodeficiency (HP:0004430)1.83777716
116Hypoplastic nipples (HP:0002557)1.83765588
117Dyskinesia (HP:0100660)1.83158771
118Thyroiditis (HP:0100646)1.82025167
119Optic nerve hypoplasia (HP:0000609)1.81990390
120Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81457848
121Dialeptic seizures (HP:0011146)1.80703699
122Aqueductal stenosis (HP:0002410)1.80635199
123Impaired vibration sensation in the lower limbs (HP:0002166)1.79538445
124Fetal akinesia sequence (HP:0001989)1.79529658
125Pancreatic cysts (HP:0001737)1.79408699
126Long nose (HP:0003189)1.79158389
127High anterior hairline (HP:0009890)1.78963674
128Abnormality of the septum pellucidum (HP:0007375)1.75563762
129Hypoplastic ischia (HP:0003175)1.74542829
130Abnormality of the pubic bones (HP:0003172)1.74199522
131Visual hallucinations (HP:0002367)1.72932106
132Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.72282649
133Short 4th metacarpal (HP:0010044)1.72282649
134Paraparesis (HP:0002385)1.71761220
135Exotropia (HP:0000577)1.71262549
136Pigmentary retinal degeneration (HP:0001146)1.71244110
137Abnormality of complement system (HP:0005339)1.70556379
138Hypoglycemic coma (HP:0001325)1.70511279
139Pachygyria (HP:0001302)1.70476584
140Dysdiadochokinesis (HP:0002075)1.69765924
141Proximal amyotrophy (HP:0007126)1.69499826
142Round face (HP:0000311)1.69462814
143Impaired social interactions (HP:0000735)1.69411342
144Abnormal social behavior (HP:0012433)1.69411342
145Broad ribs (HP:0000885)1.68390440
146Delayed CNS myelination (HP:0002188)1.67344913
147Astrocytoma (HP:0009592)1.67226356
148Abnormality of the astrocytes (HP:0100707)1.67226356
149Abnormal biliary tract physiology (HP:0012439)1.66764736
150Bile duct proliferation (HP:0001408)1.66764736
151Enlarged kidneys (HP:0000105)1.66241576
152Hip contracture (HP:0003273)1.66147752
153Abnormality of eosinophils (HP:0001879)1.65689095
154Hemiparesis (HP:0001269)1.65568773
155Postural instability (HP:0002172)1.65243938
156Blue irides (HP:0000635)1.63446040
157Cutaneous syndactyly (HP:0012725)1.62920441
158Megalencephaly (HP:0001355)1.62321379
159Hematochezia (HP:0002573)1.62217190
160Short philtrum (HP:0000322)1.62129332
161Hypoplasia of the maxilla (HP:0000327)1.61930104
162Turricephaly (HP:0000262)1.61644411
163Flat cornea (HP:0007720)1.60130937
164Abnormality of the 4th metacarpal (HP:0010012)1.59619756
165Pancreatic fibrosis (HP:0100732)1.59200777
166Neoplasm of the heart (HP:0100544)1.58770133
167Narrow forehead (HP:0000341)1.58530485
168Fair hair (HP:0002286)1.58395473
169Partial agenesis of the corpus callosum (HP:0001338)1.57513390
170Hypoplastic ilia (HP:0000946)1.57300973
171Cutaneous finger syndactyly (HP:0010554)1.56614190
172Neonatal short-limb short stature (HP:0008921)1.56259645
173Intellectual disability, severe (HP:0010864)1.55452307
174Patellar aplasia (HP:0006443)1.53808060
175Thick eyebrow (HP:0000574)1.53643929
176Overgrowth (HP:0001548)1.52325332
177Lissencephaly (HP:0001339)1.51806142
178Growth hormone deficiency (HP:0000824)1.51295133
179Inappropriate behavior (HP:0000719)1.51175579
180Mild short stature (HP:0003502)1.51141499
181Abnormal sex determination (HP:0012244)1.50235971
182Sex reversal (HP:0012245)1.50235971
183Limited hip movement (HP:0008800)1.49518848
184Abnormality of the incisor (HP:0000676)1.48317126
185Urinary urgency (HP:0000012)1.46519038

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK13.20307511
2SIK33.01485991
3MARK12.80373219
4INSRR2.77570637
5BCKDK2.43308190
6STK38L2.39102077
7NTRK22.25197313
8EPHA42.18926581
9CAMKK22.16945305
10FRK2.13481996
11MAP3K42.09045324
12CASK2.04768087
13FGFR22.02340845
14NEK61.95853837
15PHKG11.92024545
16PHKG21.92024545
17PAK61.91732194
18KSR11.84864080
19MAPK71.81116720
20NLK1.77795394
21BLK1.77718033
22MAPK121.75103960
23TXK1.71677039
24CAMK1G1.70941302
25TNIK1.70459252
26ERBB41.63105575
27MAP2K41.59817644
28LATS11.59772121
29MAP3K71.59087377
30WNK11.58342926
31TAOK31.52933344
32SGK21.52439765
33CAMKK11.52045895
34CAMK1D1.50726491
35DAPK21.49096845
36AKT31.46415477
37FGFR41.41159851
38BRD41.36523132
39NTRK31.34232275
40SIK21.33399737
41SGK31.31474557
42PAK31.30086574
43CDK191.29523410
44PRKCG1.28044668
45SGK2231.27748768
46SGK4941.27748768
47PRPF4B1.27086466
48EPHA31.25316023
49MAP2K71.24231837
50MAPK131.22313390
51ERBB21.21992391
52MAP4K11.21725934
53DYRK31.16279932
54FES1.14099640
55MINK11.07965871
56OBSCN1.06087117
57BCR1.01664510
58DYRK1A1.00995059
59NEK10.99188574
60TRIB30.99001972
61CAMK40.96072077
62EPHB20.96057763
63MARK20.93825226
64PRKAA10.92843406
65TYRO30.92714942
66ERN10.90003023
67JAK10.88741203
68LMTK20.86510471
69DDR20.86138297
70PDGFRA0.85830345
71ITK0.85665068
72STK110.84184993
73PRKCZ0.83545955
74TAOK20.82805924
75STK380.79251233
76PNCK0.79110145
77CDK120.78957126
78SYK0.77478632
79PKN20.77055257
80FGFR10.76348151
81BTK0.76279569
82UHMK10.72459115
83PINK10.72439977
84PASK0.72056943
85HCK0.71185735
86LATS20.70326935
87PRKCE0.68551017
88DYRK20.67997218
89ICK0.67904628
90CDK30.66820562
91IKBKE0.66796552
92GRK10.66605386
93ZAP700.65712444
94LCK0.63987680
95RPS6KA40.63490700
96GRK60.63372225
97FER0.63361467
98YES10.62429528
99PRKAA20.61916001
100FGFR30.61595933
101PIK3CG0.60967844
102PRKCH0.59538236
103CDK50.59055628
104MAP3K100.58585111
105TEC0.58492833
106NEK90.57776824
107CDK60.57568256
108PIK3CA0.57567379
109MTOR0.57176087
110WNK30.56608847
111ERBB30.56255801
112MARK30.55983451
113CAMK10.55921067
114GRK70.55243378
115RET0.53383936
116PKN10.52106851
117RPS6KA30.51914280
118PDGFRB0.49763353
119LYN0.48892355
120MAPK110.48224444
121TRIM280.47919736
122CSNK1G20.47612427
123CDK180.47231932
124SGK10.45902210
125PTK20.44987645
126PRKACB0.44767688
127TGFBR20.44190310
128DYRK1B0.43603173
129ROCK10.43178790
130JAK20.42754395
131GSK3B0.42410257
132RIPK10.42271979
133PRKACG0.42182297
134MAPK40.41946441
135PRKCB0.38824703
136AKT20.38460672
137CCNB10.38377194
138CSNK1D0.38352098
139MKNK20.38223181
140MAPK100.38050306
141PTK2B0.37667888
142FYN0.37662560
143PRKG10.37641982
144CDK150.37484306
145CDC42BPA0.37229527
146MAPK80.36225629
147MAPK150.35640248
148CDK40.35055700
149EGFR0.34531298
150CAMK2A0.34504448
151CSNK1A1L0.33901519

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.15401601
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.56239172
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.50343771
4Arginine biosynthesis_Homo sapiens_hsa002202.96197132
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.70300949
6Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.28408141
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.10946997
8Complement and coagulation cascades_Homo sapiens_hsa046102.01880211
9Tryptophan metabolism_Homo sapiens_hsa003802.01201034
10Fatty acid degradation_Homo sapiens_hsa000711.96354085
11Butanoate metabolism_Homo sapiens_hsa006501.95468278
12T cell receptor signaling pathway_Homo sapiens_hsa046601.92691231
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.90989914
14Nicotine addiction_Homo sapiens_hsa050331.90943392
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.90543273
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72990334
17Fatty acid metabolism_Homo sapiens_hsa012121.70681238
18Bile secretion_Homo sapiens_hsa049761.69648332
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68245023
20Colorectal cancer_Homo sapiens_hsa052101.67399601
21Lysine degradation_Homo sapiens_hsa003101.67274636
22Dorso-ventral axis formation_Homo sapiens_hsa043201.65729611
23Propanoate metabolism_Homo sapiens_hsa006401.58816039
24Amphetamine addiction_Homo sapiens_hsa050311.57402274
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.53386870
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.52457046
27Primary immunodeficiency_Homo sapiens_hsa053401.52275822
28GABAergic synapse_Homo sapiens_hsa047271.49445084
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.49219940
30Long-term potentiation_Homo sapiens_hsa047201.44669507
31Peroxisome_Homo sapiens_hsa041461.44583838
32PPAR signaling pathway_Homo sapiens_hsa033201.36676689
33Hedgehog signaling pathway_Homo sapiens_hsa043401.35555819
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34359898
35Non-small cell lung cancer_Homo sapiens_hsa052231.33850742
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.32842690
37B cell receptor signaling pathway_Homo sapiens_hsa046621.32190636
38Choline metabolism in cancer_Homo sapiens_hsa052311.28207434
39Taste transduction_Homo sapiens_hsa047421.27068813
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25610451
41FoxO signaling pathway_Homo sapiens_hsa040681.24673948
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16679474
43Renal cell carcinoma_Homo sapiens_hsa052111.15785947
44Glioma_Homo sapiens_hsa052141.15334643
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12039920
46Retinol metabolism_Homo sapiens_hsa008301.11643098
47Biosynthesis of amino acids_Homo sapiens_hsa012301.10852158
48beta-Alanine metabolism_Homo sapiens_hsa004101.09965713
49Pyruvate metabolism_Homo sapiens_hsa006201.09700241
50Neurotrophin signaling pathway_Homo sapiens_hsa047221.09244385
51Inositol phosphate metabolism_Homo sapiens_hsa005621.08727441
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.05770238
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04690877
54Long-term depression_Homo sapiens_hsa047301.04005038
55ErbB signaling pathway_Homo sapiens_hsa040121.03804003
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01683375
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01315141
58Synaptic vesicle cycle_Homo sapiens_hsa047211.00114121
59Chronic myeloid leukemia_Homo sapiens_hsa052200.97459535
60Ras signaling pathway_Homo sapiens_hsa040140.96813514
61Wnt signaling pathway_Homo sapiens_hsa043100.95923497
62Pancreatic cancer_Homo sapiens_hsa052120.95871753
63Prolactin signaling pathway_Homo sapiens_hsa049170.94874282
64Notch signaling pathway_Homo sapiens_hsa043300.94733074
65ABC transporters_Homo sapiens_hsa020100.94270842
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94131593
67Phenylalanine metabolism_Homo sapiens_hsa003600.93463071
68Insulin secretion_Homo sapiens_hsa049110.93256149
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93255412
70Selenocompound metabolism_Homo sapiens_hsa004500.92560066
71Morphine addiction_Homo sapiens_hsa050320.92475156
72MAPK signaling pathway_Homo sapiens_hsa040100.92399403
73Chemical carcinogenesis_Homo sapiens_hsa052040.91814899
74Prostate cancer_Homo sapiens_hsa052150.90375134
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.90145452
76Melanogenesis_Homo sapiens_hsa049160.89916205
77MicroRNAs in cancer_Homo sapiens_hsa052060.89008645
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.88508233
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.88116652
80Carbon metabolism_Homo sapiens_hsa012000.87944401
81Chemokine signaling pathway_Homo sapiens_hsa040620.87764013
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86685907
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86510238
84Phototransduction_Homo sapiens_hsa047440.86299312
85Serotonergic synapse_Homo sapiens_hsa047260.85763763
86Tyrosine metabolism_Homo sapiens_hsa003500.85252312
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83598491
88Estrogen signaling pathway_Homo sapiens_hsa049150.83559445
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83180071
90Vitamin digestion and absorption_Homo sapiens_hsa049770.83113457
91Osteoclast differentiation_Homo sapiens_hsa043800.83070525
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82516329
93Circadian entrainment_Homo sapiens_hsa047130.82436331
94Acute myeloid leukemia_Homo sapiens_hsa052210.82064814
95Platelet activation_Homo sapiens_hsa046110.82003396
96Starch and sucrose metabolism_Homo sapiens_hsa005000.78478688
97Staphylococcus aureus infection_Homo sapiens_hsa051500.78359416
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77433727
99Gastric acid secretion_Homo sapiens_hsa049710.76019640
100mTOR signaling pathway_Homo sapiens_hsa041500.75490955
101Glutamatergic synapse_Homo sapiens_hsa047240.75270165
102Fatty acid biosynthesis_Homo sapiens_hsa000610.74718586
103Adherens junction_Homo sapiens_hsa045200.73781190
104Hepatitis B_Homo sapiens_hsa051610.73442905
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.73375760
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73219908
107Measles_Homo sapiens_hsa051620.72449183
108GnRH signaling pathway_Homo sapiens_hsa049120.72443665
109Hippo signaling pathway_Homo sapiens_hsa043900.72368504
110Rap1 signaling pathway_Homo sapiens_hsa040150.72067374
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71634635
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71446322
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69849432
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.69755471
115Pathways in cancer_Homo sapiens_hsa052000.68345904
116Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67508295
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67137398
118Alcoholism_Homo sapiens_hsa050340.66921695
119Histidine metabolism_Homo sapiens_hsa003400.66672769
120Circadian rhythm_Homo sapiens_hsa047100.66036903
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65919692
122Axon guidance_Homo sapiens_hsa043600.64412891
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64237346
124VEGF signaling pathway_Homo sapiens_hsa043700.63614221
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63218550
126Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63202777
127Caffeine metabolism_Homo sapiens_hsa002320.62625205
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62508459
129Focal adhesion_Homo sapiens_hsa045100.61849671
130Fatty acid elongation_Homo sapiens_hsa000620.61706061
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61349418
132Glucagon signaling pathway_Homo sapiens_hsa049220.60506840
133Regulation of autophagy_Homo sapiens_hsa041400.60147661
134Arginine and proline metabolism_Homo sapiens_hsa003300.58793045
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57095433
136Olfactory transduction_Homo sapiens_hsa047400.56265017
137Fat digestion and absorption_Homo sapiens_hsa049750.55898290
138Small cell lung cancer_Homo sapiens_hsa052220.55595159
139Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54056305
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53401429
141Maturity onset diabetes of the young_Homo sapiens_hsa049500.52632236
142Salivary secretion_Homo sapiens_hsa049700.52148642
143Basal cell carcinoma_Homo sapiens_hsa052170.52130497
144Steroid biosynthesis_Homo sapiens_hsa001000.52062295
145Type II diabetes mellitus_Homo sapiens_hsa049300.51315301
146Cocaine addiction_Homo sapiens_hsa050300.51271045
147Renin secretion_Homo sapiens_hsa049240.49807350
148Prion diseases_Homo sapiens_hsa050200.49342775
149Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47750942
150Cholinergic synapse_Homo sapiens_hsa047250.45846488
151Sulfur metabolism_Homo sapiens_hsa009200.43980711
152Oxytocin signaling pathway_Homo sapiens_hsa049210.42766845
153Insulin resistance_Homo sapiens_hsa049310.42063143
154Sulfur relay system_Homo sapiens_hsa041220.41755218
155Dilated cardiomyopathy_Homo sapiens_hsa054140.40989634
156Gap junction_Homo sapiens_hsa045400.40289742
157cAMP signaling pathway_Homo sapiens_hsa040240.40124311
158Dopaminergic synapse_Homo sapiens_hsa047280.40114238
159Cyanoamino acid metabolism_Homo sapiens_hsa004600.37412252
160Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37319283
161AMPK signaling pathway_Homo sapiens_hsa041520.36695058
162Calcium signaling pathway_Homo sapiens_hsa040200.36131778
163Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35716276
164Glycerolipid metabolism_Homo sapiens_hsa005610.32857997
165Endometrial cancer_Homo sapiens_hsa052130.31857992
166cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31803298

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