KLF13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.74262680
2negative regulation of neurotransmitter secretion (GO:0046929)5.68237693
3negative regulation of cell killing (GO:0031342)5.51553387
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.51553387
5presynaptic membrane assembly (GO:0097105)5.40563584
6axon ensheathment in central nervous system (GO:0032291)4.97550435
7central nervous system myelination (GO:0022010)4.97550435
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.96292991
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.95758921
10long-chain fatty acid biosynthetic process (GO:0042759)4.94265305
11antigen processing and presentation of endogenous antigen (GO:0019883)4.86168026
12presynaptic membrane organization (GO:0097090)4.85353116
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.65780095
14negative regulation of neurotransmitter transport (GO:0051589)4.55504290
15positive regulation by symbiont of host defense response (GO:0052509)4.47018471
16modulation by symbiont of host defense response (GO:0052031)4.47018471
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.47018471
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.47018471
19positive regulation by organism of defense response of other organism involved in symbiotic interact4.47018471
20modulation by symbiont of host immune response (GO:0052553)4.47018471
21regulation of B cell receptor signaling pathway (GO:0050855)4.36135091
22detection of other organism (GO:0098543)4.32846214
23regulation of gamma-delta T cell activation (GO:0046643)4.30859326
24detection of bacterium (GO:0016045)4.21229948
25myelination (GO:0042552)4.17707684
26axon ensheathment (GO:0008366)4.12214310
27ensheathment of neurons (GO:0007272)4.12214310
28negative thymic T cell selection (GO:0045060)4.09109442
29positive thymic T cell selection (GO:0045059)4.05061871
30regulation of gamma-delta T cell differentiation (GO:0045586)4.03104565
31negative T cell selection (GO:0043383)3.95128360
32macrophage activation involved in immune response (GO:0002281)3.89670135
33oligodendrocyte differentiation (GO:0048709)3.86953218
34cellular extravasation (GO:0045123)3.82134020
35response to muramyl dipeptide (GO:0032495)3.81522049
36response to peptidoglycan (GO:0032494)3.81430822
37positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.69525190
38B cell receptor signaling pathway (GO:0050853)3.66278021
39* negative regulation of erythrocyte differentiation (GO:0045647)3.66052745
40thymic T cell selection (GO:0045061)3.64478271
41neuron cell-cell adhesion (GO:0007158)3.63713893
42T cell selection (GO:0045058)3.60681516
43neuronal action potential propagation (GO:0019227)3.56077167
44fatty acid elongation (GO:0030497)3.55808912
45positive T cell selection (GO:0043368)3.55545297
46negative regulation of lymphocyte mediated immunity (GO:0002707)3.54750674
47neutrophil activation involved in immune response (GO:0002283)3.53246609
48T cell migration (GO:0072678)3.51988347
49negative regulation of T cell mediated immunity (GO:0002710)3.50810035
50detection of external biotic stimulus (GO:0098581)3.49427010
51cyclic nucleotide catabolic process (GO:0009214)3.47001503
52negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.46080493
53response to interleukin-15 (GO:0070672)3.37978674
54inositol phosphate catabolic process (GO:0071545)3.37025981
55negative regulation of interleukin-12 production (GO:0032695)3.35280782
56myelination in peripheral nervous system (GO:0022011)3.34849608
57peripheral nervous system axon ensheathment (GO:0032292)3.34849608
58negative regulation of leukocyte mediated immunity (GO:0002704)3.29940152
59negative regulation of synaptic transmission, GABAergic (GO:0032229)3.28860472
60regulation of interferon-beta biosynthetic process (GO:0045357)3.27902333
61positive regulation of B cell differentiation (GO:0045579)3.26329785
62germinal center formation (GO:0002467)3.23391899
63negative regulation of execution phase of apoptosis (GO:1900118)3.23103547
64postsynaptic membrane organization (GO:0001941)3.19958267
65negative regulation of myoblast differentiation (GO:0045662)3.18439728
66cellular response to epinephrine stimulus (GO:0071872)3.17879917
67phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.15410233
68regulation of B cell differentiation (GO:0045577)3.14953393
69detection of biotic stimulus (GO:0009595)3.10125942
70astrocyte development (GO:0014002)3.09253523
71membrane assembly (GO:0071709)3.08819416
72mannose metabolic process (GO:0006013)3.08360658
73detection of molecule of bacterial origin (GO:0032490)3.05701305
74regulation of T cell tolerance induction (GO:0002664)3.03816680
75positive regulation of Rap GTPase activity (GO:0032854)3.03767376
76response to host immune response (GO:0052572)3.01360774
77response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.01360774
78cerebellar granule cell differentiation (GO:0021707)3.01178236
79negative regulation of dendrite morphogenesis (GO:0050774)2.98635556
80tolerance induction (GO:0002507)2.95270528
81immunoglobulin mediated immune response (GO:0016064)2.94459991
82positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.93853197
83response to host (GO:0075136)2.93293686
84response to host defenses (GO:0052200)2.93293686
85response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.93293686
86regulation of leukocyte degranulation (GO:0043300)2.92583105
87regulation of tolerance induction (GO:0002643)2.91729604
88response to laminar fluid shear stress (GO:0034616)2.91560579
89positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.91132269
90Rap protein signal transduction (GO:0032486)2.90069502
91antigen processing and presentation via MHC class Ib (GO:0002475)2.90048844
92neurotransmitter-gated ion channel clustering (GO:0072578)2.89419922
93regulation of mast cell degranulation (GO:0043304)2.89029621
94cellular response to type I interferon (GO:0071357)2.88299729
95type I interferon signaling pathway (GO:0060337)2.88299729
96myeloid cell activation involved in immune response (GO:0002275)2.88124600
97response to type I interferon (GO:0034340)2.87967833
98cellular response to interleukin-15 (GO:0071350)2.87522304
99peptidyl-tyrosine autophosphorylation (GO:0038083)2.86629007
100activated T cell proliferation (GO:0050798)2.83022211
101positive regulation of granulocyte differentiation (GO:0030854)2.80898208
102positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.80810195
103regulation of myeloid leukocyte mediated immunity (GO:0002886)2.80029724
104cellular response to catecholamine stimulus (GO:0071870)2.79740915
105cellular response to monoamine stimulus (GO:0071868)2.79740915
106interferon-gamma-mediated signaling pathway (GO:0060333)2.78364059
107peripheral nervous system development (GO:0007422)2.76457192
108response to epinephrine (GO:0071871)2.76274374
109macrophage activation (GO:0042116)2.75671584
110regulation of dendritic cell antigen processing and presentation (GO:0002604)2.75105777
111mannosylation (GO:0097502)2.74970829
112microglial cell activation (GO:0001774)2.74421099
113response to redox state (GO:0051775)2.73321749
114positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.73170920
115negative regulation of toll-like receptor signaling pathway (GO:0034122)2.71943575
116NIK/NF-kappaB signaling (GO:0038061)2.71922514
117response to catecholamine (GO:0071869)2.70891862
118response to monoamine (GO:0071867)2.70891862
119regulation of alpha-beta T cell proliferation (GO:0046640)2.70230524
120histone H3-K36 demethylation (GO:0070544)2.70126980
121respiratory burst (GO:0045730)2.69893979
122B cell homeostasis (GO:0001782)2.69134987
123negative regulation of protein localization to cell surface (GO:2000009)2.67428075
124myelin assembly (GO:0032288)2.66173680
125neutrophil activation (GO:0042119)2.65848202
126regulation of necroptotic process (GO:0060544)2.65231143
127negative regulation of type 2 immune response (GO:0002829)2.64918547
128mast cell activation (GO:0045576)2.64464423
129protein K11-linked deubiquitination (GO:0035871)2.64293523
130negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.63526269
131phagosome maturation (GO:0090382)2.62316536
132defense response to protozoan (GO:0042832)2.62276661
133regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.61902647
134regulation of natural killer cell mediated immunity (GO:0002715)2.61636191
135regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.61636191
136positive regulation of action potential (GO:0045760)2.61608762
137angiogenesis involved in wound healing (GO:0060055)2.61213158
138phosphorylated carbohydrate dephosphorylation (GO:0046838)2.60493331
139inositol phosphate dephosphorylation (GO:0046855)2.60493331
140lipopolysaccharide-mediated signaling pathway (GO:0031663)2.59912034
141leukocyte migration involved in inflammatory response (GO:0002523)2.59811302
142regulation of mast cell activation involved in immune response (GO:0033006)2.59246966
143phosphatidylinositol 3-kinase signaling (GO:0014065)2.57867247
144T cell homeostasis (GO:0043029)2.57435125
145regulation of T-helper 2 cell differentiation (GO:0045628)2.57130030
146leukocyte aggregation (GO:0070486)2.56848407
147positive regulation of cellular amide metabolic process (GO:0034250)2.56808522
148adhesion of symbiont to host cell (GO:0044650)2.56770042
149virion attachment to host cell (GO:0019062)2.56770042
150transmission of nerve impulse (GO:0019226)2.56249267
151regulation of ARF protein signal transduction (GO:0032012)2.56036408
152negative regulation of innate immune response (GO:0045824)2.56024965
153signal complex assembly (GO:0007172)2.55705716
154myelin maintenance (GO:0043217)2.55445027
155glycerophospholipid catabolic process (GO:0046475)2.54158748
156regulation of interleukin-2 biosynthetic process (GO:0045076)2.54004946
157positive regulation of membrane potential (GO:0045838)2.53343833
158protein localization to synapse (GO:0035418)2.53136547
159negative regulation of axonogenesis (GO:0050771)2.52858944
160positive regulation of smooth muscle cell migration (GO:0014911)2.52079670
161cerebral cortex radially oriented cell migration (GO:0021799)2.51984171
162synaptic transmission, glutamatergic (GO:0035249)2.51758179
163regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.51328967
164vocalization behavior (GO:0071625)2.50012617
165substantia nigra development (GO:0021762)2.48884416
166regulation of synaptic vesicle exocytosis (GO:2000300)2.48203456
167regulation of cell communication by electrical coupling (GO:0010649)2.48024460
168regulation of excitatory postsynaptic membrane potential (GO:0060079)2.46355036
169regulation of synaptic transmission, GABAergic (GO:0032228)2.45941099
170GPI anchor biosynthetic process (GO:0006506)2.45283187
171mast cell activation involved in immune response (GO:0002279)2.44336433
172mast cell degranulation (GO:0043303)2.44336433
173cellular response to gamma radiation (GO:0071480)2.42419168
174cellular response to hepatocyte growth factor stimulus (GO:0035729)2.42265022
175response to hepatocyte growth factor (GO:0035728)2.42265022
176regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.41999580
177adenosine metabolic process (GO:0046085)2.41783688
178regulated secretory pathway (GO:0045055)2.40728042
179adult walking behavior (GO:0007628)2.40504539
180cAMP catabolic process (GO:0006198)2.38980964
181negative regulation of neural precursor cell proliferation (GO:2000178)2.38223271
182regulation of protein targeting to membrane (GO:0090313)2.37581057
183synaptic vesicle exocytosis (GO:0016079)2.36896425
184long-term synaptic potentiation (GO:0060291)2.36753592
185ionotropic glutamate receptor signaling pathway (GO:0035235)2.36525815
186interferon-gamma production (GO:0032609)2.35269247
187negative regulation of synaptic transmission (GO:0050805)2.34411472
188regulation of long-term neuronal synaptic plasticity (GO:0048169)2.34269478
189regulation of dendritic spine development (GO:0060998)2.33612354
190L-amino acid import (GO:0043092)2.33132008
191positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.32145475
192neuron-neuron synaptic transmission (GO:0007270)2.31702562
193response to lipoprotein particle (GO:0055094)2.31410731
194negative regulation of exocytosis (GO:0045920)2.29847771
195nerve growth factor signaling pathway (GO:0038180)2.29457698
196ceramide biosynthetic process (GO:0046513)2.29161343
197regulation of glutamate secretion (GO:0014048)2.27497170

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.07670945
2GBX2_23144817_ChIP-Seq_PC3_Human3.87925509
3EZH2_22144423_ChIP-Seq_EOC_Human3.75744954
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.53561167
5VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.47499272
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.19141658
7* MYC_22102868_ChIP-Seq_BL_Human3.06707841
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.02449261
9* VDR_21846776_ChIP-Seq_THP-1_Human3.00351287
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.95805882
11* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.64684155
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.63629082
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.59260311
14* VDR_24763502_ChIP-Seq_THP-1_Human2.57975503
15* TCF7_22412390_ChIP-Seq_EML_Mouse2.55973174
16* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49214845
17* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.43808714
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.43684991
19* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.40961165
20* MAF_26560356_Chip-Seq_TH1_Human2.39840575
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.36171608
22* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.32522894
23SCL_19346495_ChIP-Seq_HPC-7_Human2.31728671
24* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.29925916
25* KDM2B_26808549_Chip-Seq_DND41_Human2.27411102
26* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.24361502
27TAF15_26573619_Chip-Seq_HEK293_Human2.20511958
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.17956778
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.14089809
30* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.10872409
31BRD4_27068464_Chip-Seq_AML-cells_Mouse2.09539542
32* UTX_26944678_Chip-Seq_JUKART_Human2.06496917
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.06337969
34MYB_26560356_Chip-Seq_TH2_Human2.05292260
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.05214057
36JARID2_20064375_ChIP-Seq_MESCs_Mouse2.05007593
37* RUNX1_22412390_ChIP-Seq_EML_Mouse2.01919632
38ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00710489
39SPI1_23127762_ChIP-Seq_K562_Human1.98262490
40AR_21572438_ChIP-Seq_LNCaP_Human1.95092881
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.93518571
42* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.93210746
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.89040720
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88888776
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88004709
46MYB_26560356_Chip-Seq_TH1_Human1.87940238
47RUNX_20019798_ChIP-Seq_JUKART_Human1.87360716
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.86885412
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83654211
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.82650713
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.80675736
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.80675736
53* ELK3_25401928_ChIP-Seq_HUVEC_Human1.80158733
54* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.79888504
55* LXR_22292898_ChIP-Seq_THP-1_Human1.78501811
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76352340
57* SPI1_23547873_ChIP-Seq_NB4_Human1.74403382
58EED_16625203_ChIP-ChIP_MESCs_Mouse1.74000703
59DROSHA_22980978_ChIP-Seq_HELA_Human1.73363865
60* MAF_26560356_Chip-Seq_TH2_Human1.73016144
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72421032
62GATA1_22025678_ChIP-Seq_K562_Human1.71491720
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.69494488
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.69043274
65* EZH2_27304074_Chip-Seq_ESCs_Mouse1.68942416
66* KDM2B_26808549_Chip-Seq_JURKAT_Human1.68410454
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.68293822
68JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68124708
69MTF2_20144788_ChIP-Seq_MESCs_Mouse1.67881644
70GATA1_19941826_ChIP-Seq_K562_Human1.64823782
71SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64621976
72* RNF2_27304074_Chip-Seq_ESCs_Mouse1.61744992
73SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61291538
74Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59923855
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59697827
76P300_19829295_ChIP-Seq_ESCs_Human1.56559572
77* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56171570
78BP1_19119308_ChIP-ChIP_Hs578T_Human1.55843658
79IRF8_21731497_ChIP-ChIP_J774_Mouse1.53972773
80EZH2_27294783_Chip-Seq_ESCs_Mouse1.50673672
81VDR_24787735_ChIP-Seq_THP-1_Human1.49927062
82SMAD4_21799915_ChIP-Seq_A2780_Human1.49809621
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47164515
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46411166
85ER_23166858_ChIP-Seq_MCF-7_Human1.46094710
86CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44556326
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39929715
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39203052
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37469575
90STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36952043
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36253015
92* KDM2B_26808549_Chip-Seq_K562_Human1.35680622
93GATA3_27048872_Chip-Seq_THYMUS_Human1.35568315
94TP63_17297297_ChIP-ChIP_HaCaT_Human1.34171287
95AHR_22903824_ChIP-Seq_MCF-7_Human1.32489234
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31542015
97* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30636338
98RARB_27405468_Chip-Seq_BRAIN_Mouse1.27593857
99PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26993688
100* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26343301
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.26279192
102RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26094806
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.24856189
104PU_27001747_Chip-Seq_BMDM_Mouse1.24467884
105GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24327036
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21476077
107* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20735484
108CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20705498
109IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20421614
110EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20208268
111FLI1_27457419_Chip-Seq_LIVER_Mouse1.19820453
112ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18993271
113STAT3_23295773_ChIP-Seq_U87_Human1.18737286
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17713250
115* REST_21632747_ChIP-Seq_MESCs_Mouse1.17430949
116* TCF4_23295773_ChIP-Seq_U87_Human1.16977849
117SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16751956
118NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16505499
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16430186
120BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16287285
121LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16146875
122P300_18555785_Chip-Seq_ESCs_Mouse1.15741068
123ARNT_22903824_ChIP-Seq_MCF-7_Human1.15735489
124GATA2_19941826_ChIP-Seq_K562_Human1.15547434
125CMYC_18555785_Chip-Seq_ESCs_Mouse1.15208549
126LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15103480
127TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14989921
128* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14148937
129P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13850962
130RNF2_27304074_Chip-Seq_NSC_Mouse1.13404815
131CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13362254
132NANOG_18555785_Chip-Seq_ESCs_Mouse1.13140204
133* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13081663
134P53_22387025_ChIP-Seq_ESCs_Mouse1.13066501
135E2F1_18555785_Chip-Seq_ESCs_Mouse1.12971866
136RACK7_27058665_Chip-Seq_MCF-7_Human1.11895802
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11505524
138CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10656897
139WT1_19549856_ChIP-ChIP_CCG9911_Human1.08764312
140PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08234469
141* REST_18959480_ChIP-ChIP_MESCs_Mouse1.07812863
142* PIAS1_25552417_ChIP-Seq_VCAP_Human1.07623463
143NCOR1_26117541_ChIP-Seq_K562_Human1.06316333
144TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05823551
145SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05400080
146EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05153124
147STAT3_18555785_Chip-Seq_ESCs_Mouse1.04928313
148CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04849445
149SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04311750
150LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03633597
151PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03310850
152TP53_18474530_ChIP-ChIP_U2OS_Human1.02327906
153TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02280975
154RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01825591
155CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01578308
156* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01503428
157MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01252693
158PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00644181
159EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00354592
160STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00017101
161NMYC_18555785_Chip-Seq_ESCs_Mouse0.97821780
162IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97716523
163SOX2_18555785_Chip-Seq_ESCs_Mouse0.97529869
164GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95844040
165* CBX2_27304074_Chip-Seq_ESCs_Mouse0.95519998
166SOX9_26525672_Chip-Seq_HEART_Mouse0.95497457
167TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94316529
168PU1_27457419_Chip-Seq_LIVER_Mouse0.93889351
169* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93121908
170RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93098845
171EZH2_27294783_Chip-Seq_NPCs_Mouse0.92968058
172SA1_27219007_Chip-Seq_ERYTHROID_Human0.92625977
173MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92589726
174CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92465764
175AR_25329375_ChIP-Seq_VCAP_Human0.91839759
176RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91597824
177NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91461478
178NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91461478
179CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91444829
180* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90736884
181KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89512880
182DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88634711
183P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87073508
184RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85408792
185BCOR_27268052_Chip-Seq_Bcells_Human0.85152334
186PPARA_22158963_ChIP-Seq_LIVER_Mouse0.84367890
187* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83588456
188SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83559674

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.00650904
2MP0000920_abnormal_myelination3.82957096
3MP0003436_decreased_susceptibility_to3.81732282
4MP0003303_peritoneal_inflammation3.76550447
5MP0004859_abnormal_synaptic_plasticity3.13939604
6MP0005171_absent_coat_pigmentation2.97716732
7MP0000685_abnormal_immune_system2.93485086
8MP0004270_analgesia2.90094253
9MP0003300_gastrointestinal_ulcer2.88380441
10MP0005646_abnormal_pituitary_gland2.75613737
11MP0001905_abnormal_dopamine_level2.61603154
12MP0005409_darkened_coat_color2.48588030
13MP0002272_abnormal_nervous_system2.44824111
14MP0002064_seizures2.38370065
15MP0009745_abnormal_behavioral_response2.31156825
16MP0003635_abnormal_synaptic_transmissio2.23352119
17MP0004742_abnormal_vestibular_system2.19176239
18MP0001188_hyperpigmentation2.19094766
19MP0005645_abnormal_hypothalamus_physiol2.15250541
20MP0003690_abnormal_glial_cell2.11515286
21MP0006082_CNS_inflammation2.11058838
22MP0004947_skin_inflammation2.09371706
23MP0002735_abnormal_chemical_nociception2.05366978
24MP0005451_abnormal_body_composition2.03034762
25MP0001486_abnormal_startle_reflex1.99235224
26* MP0002398_abnormal_bone_marrow1.97318322
27MP0003172_abnormal_lysosome_physiology1.97138864
28MP0008569_lethality_at_weaning1.92299616
29MP0004885_abnormal_endolymph1.91737429
30MP0008260_abnormal_autophagy1.89314215
31MP0003136_yellow_coat_color1.88772629
32MP0010155_abnormal_intestine_physiology1.88027096
33MP0002405_respiratory_system_inflammati1.86143901
34MP0002396_abnormal_hematopoietic_system1.85645831
35MP0002063_abnormal_learning/memory/cond1.84808915
36MP0009046_muscle_twitch1.84447437
37MP0002734_abnormal_mechanical_nocicepti1.82973258
38MP0003828_pulmonary_edema1.82794546
39MP0005464_abnormal_platelet_physiology1.80168145
40MP0003724_increased_susceptibility_to1.76512295
41MP0002572_abnormal_emotion/affect_behav1.76242393
42MP0001533_abnormal_skeleton_physiology1.75599938
43MP0004142_abnormal_muscle_tone1.75090794
44MP0004381_abnormal_hair_follicle1.70089661
45MP0009278_abnormal_bone_marrow1.69804110
46MP0000015_abnormal_ear_pigmentation1.69659289
47MP0005671_abnormal_response_to1.65394564
48MP0003950_abnormal_plasma_membrane1.60482404
49MP0001851_eye_inflammation1.60154951
50MP0002166_altered_tumor_susceptibility1.59756112
51MP0004147_increased_porphyrin_level1.57097926
52* MP0002722_abnormal_immune_system1.56058843
53MP0001968_abnormal_touch/_nociception1.54295077
54* MP0000703_abnormal_thymus_morphology1.53693634
55MP0001845_abnormal_inflammatory_respons1.52966348
56MP0002148_abnormal_hypersensitivity_rea1.52665746
57MP0000372_irregular_coat_pigmentation1.52657620
58* MP0000689_abnormal_spleen_morphology1.52465916
59MP0002736_abnormal_nociception_after1.50007994
60MP0002009_preneoplasia1.48684683
61* MP0009333_abnormal_splenocyte_physiolog1.47750322
62MP0002822_catalepsy1.47600988
63MP0003656_abnormal_erythrocyte_physiolo1.47093003
64MP0002998_abnormal_bone_remodeling1.46958992
65* MP0002429_abnormal_blood_cell1.46760465
66MP0003866_abnormal_defecation1.46150869
67MP0000778_abnormal_nervous_system1.44575946
68MP0002067_abnormal_sensory_capabilities1.44297815
69MP0001502_abnormal_circadian_rhythm1.42593569
70MP0005058_abnormal_lysosome_morphology1.41903528
71MP0001984_abnormal_olfaction1.41316177
72MP0003634_abnormal_glial_cell1.40077613
73MP0001485_abnormal_pinna_reflex1.39921186
74MP0002229_neurodegeneration1.38632170
75MP0000858_altered_metastatic_potential1.36013885
76MP0002132_abnormal_respiratory_system1.33648465
77MP0000465_gastrointestinal_hemorrhage1.33518163
78MP0003091_abnormal_cell_migration1.31431246
79MP0001545_abnormal_hematopoietic_system1.30025158
80MP0005397_hematopoietic_system_phenotyp1.30025158
81MP0003705_abnormal_hypodermis_morpholog1.30013986
82MP0003787_abnormal_imprinting1.29799797
83MP0001177_atelectasis1.29535626
84MP0005076_abnormal_cell_differentiation1.25720397
85MP0002876_abnormal_thyroid_physiology1.23923505
86MP0001970_abnormal_pain_threshold1.23544337
87MP0003183_abnormal_peptide_metabolism1.23222410
88MP0004924_abnormal_behavior1.22042932
89MP0005386_behavior/neurological_phenoty1.22042932
90MP0002419_abnormal_innate_immunity1.19294686
91MP0005000_abnormal_immune_tolerance1.19022569
92MP0005387_immune_system_phenotype1.18489688
93MP0001790_abnormal_immune_system1.18489688
94MP0009785_altered_susceptibility_to1.17254348
95MP0001529_abnormal_vocalization1.17143482
96MP0008469_abnormal_protein_level1.15487127
97MP0001873_stomach_inflammation1.15125012
98MP0004808_abnormal_hematopoietic_stem1.13915469
99MP0003045_fibrosis1.12522354
100MP0009840_abnormal_foam_cell1.12476615
101MP0003631_nervous_system_phenotype1.12251971
102MP0003075_altered_response_to1.11804370
103MP0002138_abnormal_hepatobiliary_system1.10368945
104* MP0002420_abnormal_adaptive_immunity1.09924639
105MP0000604_amyloidosis1.09907912
106MP0004130_abnormal_muscle_cell1.09746909
107MP0001963_abnormal_hearing_physiology1.09411161
108MP0001986_abnormal_taste_sensitivity1.08173332
109MP0004883_abnormal_blood_vessel1.08033353
110MP0005166_decreased_susceptibility_to1.07330305
111* MP0003763_abnormal_thymus_physiology1.07118679
112MP0001853_heart_inflammation1.07006477
113MP0001501_abnormal_sleep_pattern1.06802977
114MP0002882_abnormal_neuron_morphology1.06705854
115MP0004134_abnormal_chest_morphology1.05907645
116* MP0001819_abnormal_immune_cell1.05751934
117MP0006292_abnormal_olfactory_placode1.05011392
118MP0001835_abnormal_antigen_presentation1.04999599
119MP0003633_abnormal_nervous_system1.04136168
120MP0003632_abnormal_nervous_system1.02965306
121MP0003453_abnormal_keratinocyte_physiol1.02335094
122MP0005310_abnormal_salivary_gland1.01972606
123MP0005075_abnormal_melanosome_morpholog1.00333514
124MP0002006_tumorigenesis0.99871179
125MP0002723_abnormal_immune_serum0.98696242
126MP0002933_joint_inflammation0.97777828
127MP0002066_abnormal_motor_capabilities/c0.96791919
128MP0005025_abnormal_response_to0.96300346
129MP0008874_decreased_physiological_sensi0.95792910
130MP0001800_abnormal_humoral_immune0.94185141
131MP0009764_decreased_sensitivity_to0.93046941
132MP0003448_altered_tumor_morphology0.92356598
133MP0004811_abnormal_neuron_physiology0.91399412
134MP0002733_abnormal_thermal_nociception0.91356175
135MP0002452_abnormal_antigen_presenting0.90154918
136MP0000955_abnormal_spinal_cord0.88882911
137MP0003191_abnormal_cellular_cholesterol0.88289152
138MP0000681_abnormal_thyroid_gland0.85372192
139MP0003566_abnormal_cell_adhesion0.85176281
140MP0009780_abnormal_chondrocyte_physiolo0.85133246
141MP0002557_abnormal_social/conspecific_i0.82996822
142MP0004510_myositis0.82945906
143MP0000026_abnormal_inner_ear0.82822806
144MP0005666_abnormal_adipose_tissue0.82224659
145MP0004185_abnormal_adipocyte_glucose0.80902345
146MP0005164_abnormal_response_to0.80759826
147MP0005388_respiratory_system_phenotype0.80205731
148MP0002133_abnormal_respiratory_system0.80205731
149MP0000631_abnormal_neuroendocrine_gland0.80205644
150MP0003879_abnormal_hair_cell0.79850266
151MP0000249_abnormal_blood_vessel0.78971435
152MP0008004_abnormal_stomach_pH0.77411606
153MP0004782_abnormal_surfactant_physiolog0.77171685
154MP0002751_abnormal_autonomic_nervous0.76260878
155* MP0000716_abnormal_immune_system0.75047594
156MP0001663_abnormal_digestive_system0.73795219
157MP0001440_abnormal_grooming_behavior0.73754356
158MP0000490_abnormal_crypts_of0.73260069
159MP0009115_abnormal_fat_cell0.73075148
160MP0003329_amyloid_beta_deposits0.72019173
161MP0009763_increased_sensitivity_to0.70062340
162MP0005174_abnormal_tail_pigmentation0.69976629
163MP0005390_skeleton_phenotype0.69173244
164MP0001348_abnormal_lacrimal_gland0.68943036
165MP0003943_abnormal_hepatobiliary_system0.68335183
166MP0000343_altered_response_to0.67131166
167MP0003795_abnormal_bone_structure0.63800147
168MP0001849_ear_inflammation0.63732839
169MP0001958_emphysema0.63300621

Predicted human phenotypes

RankGene SetZ-score
1Sensory axonal neuropathy (HP:0003390)5.47705259
2Atonic seizures (HP:0010819)4.81417937
3Recurrent bacterial skin infections (HP:0005406)4.31243992
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.12215445
5Degeneration of the lateral corticospinal tracts (HP:0002314)4.12215445
6Abnormality of macrophages (HP:0004311)3.88726614
7Myositis (HP:0100614)3.80607713
8Febrile seizures (HP:0002373)3.66749178
9Focal motor seizures (HP:0011153)3.65192609
10Akinesia (HP:0002304)3.50736087
11Increased IgE level (HP:0003212)3.50566436
12Hyperventilation (HP:0002883)3.50429346
13Orchitis (HP:0100796)3.47013251
14Spontaneous hematomas (HP:0007420)3.46565581
15Epileptic encephalopathy (HP:0200134)3.45597120
16Recurrent gram-negative bacterial infections (HP:0005420)3.42852791
17Recurrent fungal infections (HP:0002841)3.40990057
18Abnormal hair whorl (HP:0010721)3.34742077
19Hypothermia (HP:0002045)3.32983351
20Fetal akinesia sequence (HP:0001989)3.32038192
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.29869402
22Optic neuritis (HP:0100653)3.28008415
23Retrobulbar optic neuritis (HP:0100654)3.28008415
24Cellulitis (HP:0100658)3.27385514
25Mediastinal lymphadenopathy (HP:0100721)3.25663203
26Pheochromocytoma (HP:0002666)3.20261365
27Gastrointestinal infarctions (HP:0005244)3.20236433
28Recurrent viral infections (HP:0004429)3.12281976
29Parakeratosis (HP:0001036)3.06405387
30Stomatitis (HP:0010280)3.02879527
31Recurrent skin infections (HP:0001581)3.01912114
32Elevated erythrocyte sedimentation rate (HP:0003565)2.99886232
33Recurrent cutaneous fungal infections (HP:0011370)2.95530936
34Chronic mucocutaneous candidiasis (HP:0002728)2.95530936
35Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.94500125
36Vasculitis (HP:0002633)2.94425097
37Gingivitis (HP:0000230)2.94119362
38Colitis (HP:0002583)2.93820591
39Aqueductal stenosis (HP:0002410)2.85063406
40Neuroendocrine neoplasm (HP:0100634)2.84599116
41Pustule (HP:0200039)2.83103500
42Inflammation of the large intestine (HP:0002037)2.80159339
43Gastrointestinal inflammation (HP:0004386)2.77665631
44Prolonged bleeding time (HP:0003010)2.73464562
45Abnormality of the corticospinal tract (HP:0002492)2.72632222
46Thickened helices (HP:0000391)2.69967835
47Encephalitis (HP:0002383)2.65836952
48Keratoconjunctivitis sicca (HP:0001097)2.62919876
49Panhypogammaglobulinemia (HP:0003139)2.62708910
50Gaze-evoked nystagmus (HP:0000640)2.58701898
51Abnormality of the fingertips (HP:0001211)2.54313639
52Chest pain (HP:0100749)2.53541476
53Urticaria (HP:0001025)2.53125842
54Abnormal auditory evoked potentials (HP:0006958)2.51333695
55Myokymia (HP:0002411)2.50881543
56Pulmonary infiltrates (HP:0002113)2.49857637
57Osteomyelitis (HP:0002754)2.46004355
58Dysmetria (HP:0001310)2.44018073
59Gastrointestinal stroma tumor (HP:0100723)2.43126359
60Xerostomia (HP:0000217)2.42424007
61Papilledema (HP:0001085)2.42146985
62Slow saccadic eye movements (HP:0000514)2.41250327
63Epistaxis (HP:0000421)2.39715268
64Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.37561701
65Submucous cleft hard palate (HP:0000176)2.33843560
66White forelock (HP:0002211)2.33716127
67Abnormality of the nasal septum (HP:0000419)2.32430126
68Keratoconjunctivitis (HP:0001096)2.31712485
69Scanning speech (HP:0002168)2.31374621
70Hemoptysis (HP:0002105)2.29935180
71Autoamputation (HP:0001218)2.29130716
72Gingival bleeding (HP:0000225)2.28357960
73Verrucae (HP:0200043)2.27843294
74Papilloma (HP:0012740)2.27843294
75Recurrent abscess formation (HP:0002722)2.27600176
76Intention tremor (HP:0002080)2.27419309
77Spastic gait (HP:0002064)2.26632176
78Abnormality of incisor morphology (HP:0011063)2.24685912
79Chronic obstructive pulmonary disease (HP:0006510)2.24127056
80Obstructive lung disease (HP:0006536)2.24127056
81Diminished movement (HP:0002374)2.23171886
82Peripheral hypomyelination (HP:0007182)2.22108175
83Cerebral hypomyelination (HP:0006808)2.21093632
84Obstructive sleep apnea (HP:0002870)2.20017903
85Abnormality of T cells (HP:0002843)2.19203513
86Duplicated collecting system (HP:0000081)2.19051172
87Patchy hypopigmentation of hair (HP:0011365)2.18485681
88Viral hepatitis (HP:0006562)2.18021382
89Lymphopenia (HP:0001888)2.14661553
90Leukocytosis (HP:0001974)2.13880165
91Arterial thrombosis (HP:0004420)2.13446875
92Hypochromic anemia (HP:0001931)2.12941910
93Generalized myoclonic seizures (HP:0002123)2.11157721
94Stomach cancer (HP:0012126)2.10860533
95Granulocytopenia (HP:0001913)2.10586601
96Relative macrocephaly (HP:0004482)2.10470654
97Abnormality of the renal collecting system (HP:0004742)2.09813877
98Pulmonary embolism (HP:0002204)2.08562481
99Sleep apnea (HP:0010535)2.07377907
100Polycythemia (HP:0001901)2.06675810
101Optic nerve hypoplasia (HP:0000609)2.06555758
102Abnormality of cells of the lymphoid lineage (HP:0012140)2.06281840
103T lymphocytopenia (HP:0005403)2.05922867
104Lower limb muscle weakness (HP:0007340)2.04489896
105Type I transferrin isoform profile (HP:0003642)2.03617073
106Autoimmune hemolytic anemia (HP:0001890)2.02236089
107Broad-based gait (HP:0002136)1.98440647
108Abnormality of T cell number (HP:0011839)1.98072203
109Recurrent bronchitis (HP:0002837)1.97467124
110Amyloidosis (HP:0011034)1.97188458
111Curly hair (HP:0002212)1.96715376
112Fatigue (HP:0012378)1.96543920
113Morphological abnormality of the inner ear (HP:0011390)1.96346215
114Autoimmune thrombocytopenia (HP:0001973)1.95334509
115Chronic otitis media (HP:0000389)1.94652224
116Polygenic inheritance (HP:0010982)1.94132577
117Dysostosis multiplex (HP:0000943)1.93425939
118Sepsis (HP:0100806)1.93401126
119Congenital ichthyosiform erythroderma (HP:0007431)1.92773688
120Hypochromic microcytic anemia (HP:0004840)1.92556180
121Conical tooth (HP:0000698)1.92383998
122Interstitial pulmonary disease (HP:0006530)1.92234325
123Restrictive lung disease (HP:0002091)1.92056850
124Focal seizures (HP:0007359)1.91595251
125Skin ulcer (HP:0200042)1.91242001
126Neurofibrillary tangles (HP:0002185)1.91224933
127Increased cerebral lipofuscin (HP:0011813)1.90885458
128Septo-optic dysplasia (HP:0100842)1.90852252
129Hypergammaglobulinemia (HP:0010702)1.89275777
130Agammaglobulinemia (HP:0004432)1.88879683
131Emphysema (HP:0002097)1.88546489
132Eosinophilia (HP:0001880)1.88178147
133Onion bulb formation (HP:0003383)1.87834757
134Subacute progressive viral hepatitis (HP:0006572)1.87296859
135Absent septum pellucidum (HP:0001331)1.86878095
136Microcytic anemia (HP:0001935)1.85969133
137Abnormality of liposaccharide metabolism (HP:0010968)1.85753594
138Abnormality of glycosphingolipid metabolism (HP:0004343)1.85753594
139Abnormality of glycolipid metabolism (HP:0010969)1.85753594
140Meningitis (HP:0001287)1.84879829
141Segmental peripheral demyelination/remyelination (HP:0003481)1.84313170
142Blue irides (HP:0000635)1.83823198
143Premature skin wrinkling (HP:0100678)1.81782470
144Abnormality of molar (HP:0011077)1.81122377
145Abnormality of molar morphology (HP:0011070)1.81122377
146Eczematoid dermatitis (HP:0000976)1.81058068
147Abnormality of T cell physiology (HP:0011840)1.80107060
148Systemic lupus erythematosus (HP:0002725)1.80101747
149Thyroiditis (HP:0100646)1.79812273
150Supranuclear gaze palsy (HP:0000605)1.79511302
151Hepatosplenomegaly (HP:0001433)1.78198384
152Stridor (HP:0010307)1.77088657
153Recurrent pneumonia (HP:0006532)1.77040635
154Dysphonia (HP:0001618)1.76912387
155Increased IgM level (HP:0003496)1.76701217
156Asymmetry of the thorax (HP:0001555)1.76489078
157Poor speech (HP:0002465)1.75537435
158Prolonged neonatal jaundice (HP:0006579)1.75529188
159Cerebral aneurysm (HP:0004944)1.74243364
160Hematochezia (HP:0002573)1.74192347
161Urinary bladder sphincter dysfunction (HP:0002839)1.74000050
162Episodic fever (HP:0001954)1.73247679
163Malnutrition (HP:0004395)1.73190237
164Abnormality of the peritoneum (HP:0002585)1.73165541
165IgM deficiency (HP:0002850)1.72960269
166Nonprogressive disorder (HP:0003680)1.72494595
167Neuronal loss in central nervous system (HP:0002529)1.71142763
168Loss of speech (HP:0002371)1.69498678
169Abnormality of B cell number (HP:0010975)1.68343545
170B lymphocytopenia (HP:0010976)1.68343545
171Abnormal platelet volume (HP:0011876)1.68242043
172Premature loss of primary teeth (HP:0006323)1.67247126
173Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.67129487
174Progressive cerebellar ataxia (HP:0002073)1.65510423
175Purpura (HP:0000979)1.65442277
176Abnormality of eosinophils (HP:0001879)1.65413838
177Barrel-shaped chest (HP:0001552)1.65101792
178Tubulointerstitial nephritis (HP:0001970)1.64144419
179Abnormality of cochlea (HP:0000375)1.63375877
180Severe combined immunodeficiency (HP:0004430)1.63067244
181Widely spaced teeth (HP:0000687)1.62922148
182Bowel incontinence (HP:0002607)1.62113170
183Medial flaring of the eyebrow (HP:0010747)1.61867011
184Bradycardia (HP:0001662)1.60392304
185Syringomyelia (HP:0003396)1.60350849
186Spinal cord lesions (HP:0100561)1.60350849
187Abnormality of the septum pellucidum (HP:0007375)1.60323607
188Limb dystonia (HP:0002451)1.60234019
189Action tremor (HP:0002345)1.59024137
190Abnormal large intestine physiology (HP:0012700)1.58272413

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.43582130
2OXSR12.92809089
3CDK192.81118699
4TNIK2.68492063
5TXK2.56852696
6ERN12.54840174
7TYK22.51683926
8STK392.37073139
9CLK12.35588851
10AKT32.30478942
11MAP2K32.30462049
12TRIB32.28791092
13MAP3K142.17415093
14BCR2.07344612
15YES11.94730680
16SGK2231.94571916
17SGK4941.94571916
18ZAP701.93887184
19NUAK11.90878076
20SGK21.89431130
21BMPR21.87877075
22NEK61.79455941
23MAP3K101.76872003
24BTK1.58242272
25EPHA41.57978671
26SIK31.55258375
27JAK31.54751953
28CDK121.51731360
29FES1.51287161
30GRK61.51241000
31SGK31.49819340
32PKN11.49445918
33EPHB11.49268012
34RIPK11.48470991
35FGFR41.47607117
36SMG11.45935990
37* PRPF4B1.45286966
38IRAK41.43794240
39MAP4K11.38582597
40MAP3K31.34978879
41MAP3K11.31240515
42MST41.30924296
43TBK11.29762771
44KSR21.29524567
45SIK21.27215123
46MAP2K71.27110937
47MAP3K121.26482414
48TAOK11.25456927
49SIK11.23572908
50UHMK11.20515844
51MAPK121.20346643
52PRKCH1.20025534
53MKNK21.19008428
54JAK21.16957353
55FGFR21.10948669
56ROCK21.09901663
57ADRBK21.06641150
58TRPM71.06293639
59TAOK31.05969355
60CAMKK11.05634311
61TNK21.05183017
62IKBKE1.04957754
63TAOK21.04352060
64CAMK2B1.03842961
65CDC42BPA1.03787719
66DAPK21.03183520
67MAP3K111.01039872
68TTN1.00275042
69BMPR1B0.99564665
70LYN0.98342323
71EEF2K0.97768615
72PLK20.97551021
73PDK10.97360784
74CSF1R0.95200872
75KIT0.94478709
76MAPK130.92375042
77MAP3K70.91605484
78ITK0.91540446
79ICK0.89968617
80MAPK70.88847533
81HIPK20.88531636
82PDPK10.87652769
83CSNK1A1L0.83302542
84MARK30.82531127
85MAP3K130.81123028
86NTRK30.79446008
87MUSK0.78696450
88TGFBR20.77070319
89CDK50.75757019
90GRK70.75388518
91IKBKB0.75110932
92CSNK1G30.74488628
93NLK0.74067384
94IRAK20.73013190
95PRKD20.72472045
96PRKCQ0.72139314
97CSK0.71609340
98BLK0.71598602
99CAMK2A0.70983453
100CDK60.70353266
101MAP3K60.69759495
102WNK10.69633325
103IRAK30.69589462
104STK100.69509858
105MAPK110.68047410
106CDK40.67942857
107IRAK10.67079809
108MAP3K20.66774960
109RET0.66770442
110LCK0.65632940
111PTK60.64656211
112TEC0.63952675
113SYK0.63762973
114LATS10.63542630
115PIK3CG0.61224772
116PIM10.60971629
117PRKCE0.60316420
118LRRK20.58163797
119FGR0.57936308
120CAMK2D0.57557842
121MINK10.54951147
122STK240.54314566
123MATK0.53647151
124BRD40.53246782
125RIPK40.52713387
126DYRK1B0.52594655
127CSNK1G10.52157391
128CDK180.51780354
129MELK0.51751698
130DAPK10.50115163
131PINK10.50096820
132FGFR30.49601879
133NTRK20.49531115
134ERBB30.48514457
135CDK80.48282586
136PKN20.48214207
137CDK140.47484518
138STK110.47386235
139MKNK10.46355479
140PDGFRB0.46137269
141MAPK40.46009261
142HCK0.44683297
143JAK10.44214772
144RPS6KA60.44211558
145PRKG10.44035834
146CAMKK20.43666028
147CSNK1G20.43111782
148CDK150.42960397
149FYN0.42869360
150CSNK1A10.42035706
151SGK10.41969603
152STK160.41842636
153RPS6KL10.41376510
154RPS6KC10.41376510
155PTK2B0.40693804
156LIMK10.40546649
157MARK20.40424158
158CAMK2G0.39766886
159GRK50.37301627
160DYRK1A0.36966392
161CDK11A0.36966203
162MET0.35143815
163PRKCG0.34845596

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.14012754
2Olfactory transduction_Homo sapiens_hsa047402.17931793
3Synaptic vesicle cycle_Homo sapiens_hsa047211.99892597
4Collecting duct acid secretion_Homo sapiens_hsa049661.97969433
5Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.97427901
6Staphylococcus aureus infection_Homo sapiens_hsa051501.92271198
7Steroid biosynthesis_Homo sapiens_hsa001001.87004367
8Primary immunodeficiency_Homo sapiens_hsa053401.86607856
9Rheumatoid arthritis_Homo sapiens_hsa053231.81054328
10Morphine addiction_Homo sapiens_hsa050321.77293591
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.72955097
12SNARE interactions in vesicular transport_Homo sapiens_hsa041301.71449196
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70209755
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.69076647
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.66244046
16Fatty acid elongation_Homo sapiens_hsa000621.62156835
17Nicotine addiction_Homo sapiens_hsa050331.60972972
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.59895791
19Serotonergic synapse_Homo sapiens_hsa047261.59847333
20T cell receptor signaling pathway_Homo sapiens_hsa046601.59024931
21Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.58197256
22Non-small cell lung cancer_Homo sapiens_hsa052231.58196007
23Other glycan degradation_Homo sapiens_hsa005111.53547384
24Axon guidance_Homo sapiens_hsa043601.53122411
25Circadian entrainment_Homo sapiens_hsa047131.51862186
26Glutamatergic synapse_Homo sapiens_hsa047241.50856016
27Vibrio cholerae infection_Homo sapiens_hsa051101.50518667
28Toxoplasmosis_Homo sapiens_hsa051451.49331732
29Chronic myeloid leukemia_Homo sapiens_hsa052201.46953422
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43781841
31Influenza A_Homo sapiens_hsa051641.41390572
32Chemokine signaling pathway_Homo sapiens_hsa040621.37091140
33Sphingolipid metabolism_Homo sapiens_hsa006001.35776185
34Viral myocarditis_Homo sapiens_hsa054161.33365935
35Pancreatic cancer_Homo sapiens_hsa052121.29924648
36Type I diabetes mellitus_Homo sapiens_hsa049401.28689412
37Autoimmune thyroid disease_Homo sapiens_hsa053201.27774665
38Hepatitis B_Homo sapiens_hsa051611.27524150
39TNF signaling pathway_Homo sapiens_hsa046681.27291275
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27158457
41VEGF signaling pathway_Homo sapiens_hsa043701.25953888
42Taste transduction_Homo sapiens_hsa047421.25657954
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25260375
44Cholinergic synapse_Homo sapiens_hsa047251.23925179
45Long-term depression_Homo sapiens_hsa047301.22712669
46GABAergic synapse_Homo sapiens_hsa047271.22349889
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19641217
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.19534956
49Ether lipid metabolism_Homo sapiens_hsa005651.18180476
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18148773
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17596951
52Phagosome_Homo sapiens_hsa041451.17519946
53Antigen processing and presentation_Homo sapiens_hsa046121.17234724
54Long-term potentiation_Homo sapiens_hsa047201.16621237
55B cell receptor signaling pathway_Homo sapiens_hsa046621.16111031
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15488126
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14281900
58Platelet activation_Homo sapiens_hsa046111.11863514
59Herpes simplex infection_Homo sapiens_hsa051681.11255111
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10734535
61ErbB signaling pathway_Homo sapiens_hsa040121.07720706
62Dopaminergic synapse_Homo sapiens_hsa047281.06632274
63Malaria_Homo sapiens_hsa051441.06181476
64Graft-versus-host disease_Homo sapiens_hsa053321.05706264
65Allograft rejection_Homo sapiens_hsa053301.04507770
66Prolactin signaling pathway_Homo sapiens_hsa049171.03840512
67GnRH signaling pathway_Homo sapiens_hsa049121.03734577
68Ras signaling pathway_Homo sapiens_hsa040141.01494843
69Salivary secretion_Homo sapiens_hsa049701.01119704
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98377256
71Vitamin B6 metabolism_Homo sapiens_hsa007500.96915003
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95665084
73Apoptosis_Homo sapiens_hsa042100.95548789
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94511165
75Measles_Homo sapiens_hsa051620.93397045
76Notch signaling pathway_Homo sapiens_hsa043300.91359240
77Amphetamine addiction_Homo sapiens_hsa050310.90737174
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88386845
79Phototransduction_Homo sapiens_hsa047440.87617365
80mTOR signaling pathway_Homo sapiens_hsa041500.87169610
81Choline metabolism in cancer_Homo sapiens_hsa052310.87032958
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.86041127
83Inositol phosphate metabolism_Homo sapiens_hsa005620.84976804
84Hematopoietic cell lineage_Homo sapiens_hsa046400.84901090
85Dorso-ventral axis formation_Homo sapiens_hsa043200.84800351
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82767751
87Glioma_Homo sapiens_hsa052140.82601969
88Salmonella infection_Homo sapiens_hsa051320.82593581
89FoxO signaling pathway_Homo sapiens_hsa040680.82077319
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.81411188
91Endocytosis_Homo sapiens_hsa041440.80846352
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80410952
93Colorectal cancer_Homo sapiens_hsa052100.80203658
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.78785273
95Hepatitis C_Homo sapiens_hsa051600.77804131
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.76293999
97Calcium signaling pathway_Homo sapiens_hsa040200.75152337
98Gastric acid secretion_Homo sapiens_hsa049710.74153519
99Legionellosis_Homo sapiens_hsa051340.73595829
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73322101
101Protein export_Homo sapiens_hsa030600.72650268
102MAPK signaling pathway_Homo sapiens_hsa040100.71575562
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71525758
104Insulin resistance_Homo sapiens_hsa049310.71399330
105HTLV-I infection_Homo sapiens_hsa051660.71128654
106cAMP signaling pathway_Homo sapiens_hsa040240.70405078
107Amoebiasis_Homo sapiens_hsa051460.70146545
108Leishmaniasis_Homo sapiens_hsa051400.69863182
109HIF-1 signaling pathway_Homo sapiens_hsa040660.69630602
110Tuberculosis_Homo sapiens_hsa051520.69481622
111Prostate cancer_Homo sapiens_hsa052150.68498064
112Viral carcinogenesis_Homo sapiens_hsa052030.67704279
113Estrogen signaling pathway_Homo sapiens_hsa049150.67695841
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.67164921
115Pertussis_Homo sapiens_hsa051330.66441555
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66334347
117Type II diabetes mellitus_Homo sapiens_hsa049300.65221561
118Renin secretion_Homo sapiens_hsa049240.65097736
119Acute myeloid leukemia_Homo sapiens_hsa052210.64606545
120African trypanosomiasis_Homo sapiens_hsa051430.63329761
121Shigellosis_Homo sapiens_hsa051310.62969635
122Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61681840
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.61666137
124Osteoclast differentiation_Homo sapiens_hsa043800.61637121
125Insulin signaling pathway_Homo sapiens_hsa049100.61000298
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60880863
127Oxidative phosphorylation_Homo sapiens_hsa001900.60074833
128Epstein-Barr virus infection_Homo sapiens_hsa051690.59780077
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58721872
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58077853
131Gap junction_Homo sapiens_hsa045400.57618175
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.57590676
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57479933
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57064039
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56431296
136Lysosome_Homo sapiens_hsa041420.56341138
137Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56037445
138NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55313976
139Thyroid cancer_Homo sapiens_hsa052160.54276192
140Arachidonic acid metabolism_Homo sapiens_hsa005900.53501298
141Rap1 signaling pathway_Homo sapiens_hsa040150.53192920
142Oxytocin signaling pathway_Homo sapiens_hsa049210.52925311
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51554516
144Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50639171
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.50464274
146Asthma_Homo sapiens_hsa053100.49907098
147Prion diseases_Homo sapiens_hsa050200.49565776
148Insulin secretion_Homo sapiens_hsa049110.49281111
149Renal cell carcinoma_Homo sapiens_hsa052110.49208153
150Small cell lung cancer_Homo sapiens_hsa052220.48793068
151Wnt signaling pathway_Homo sapiens_hsa043100.48179239
152Endometrial cancer_Homo sapiens_hsa052130.48168282
153Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46124567

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