KLF15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.31703265
2L-phenylalanine catabolic process (GO:0006559)7.31703265
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.02271481
4L-phenylalanine metabolic process (GO:0006558)7.02271481
5aromatic amino acid family catabolic process (GO:0009074)6.50634004
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.89869179
7indole-containing compound catabolic process (GO:0042436)5.82162273
8indolalkylamine catabolic process (GO:0046218)5.82162273
9tryptophan catabolic process (GO:0006569)5.82162273
10kynurenine metabolic process (GO:0070189)5.78280285
11glyoxylate metabolic process (GO:0046487)5.68906741
12bile acid biosynthetic process (GO:0006699)5.56367867
13cysteine metabolic process (GO:0006534)5.51574033
14alpha-linolenic acid metabolic process (GO:0036109)5.49665742
15tryptophan metabolic process (GO:0006568)5.47095364
16sulfur amino acid catabolic process (GO:0000098)5.41296481
17urea metabolic process (GO:0019627)5.23810255
18urea cycle (GO:0000050)5.23810255
19exogenous drug catabolic process (GO:0042738)5.12097170
20lysine catabolic process (GO:0006554)5.10065293
21lysine metabolic process (GO:0006553)5.10065293
22serine family amino acid catabolic process (GO:0009071)5.06911204
23high-density lipoprotein particle remodeling (GO:0034375)5.01733900
24negative regulation of fibrinolysis (GO:0051918)4.96996496
25complement activation, alternative pathway (GO:0006957)4.94170075
26homocysteine metabolic process (GO:0050667)4.93438371
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.88112180
28peptidyl-glutamic acid carboxylation (GO:0017187)4.85494463
29protein carboxylation (GO:0018214)4.85494463
30nitrogen cycle metabolic process (GO:0071941)4.83524059
31regulation of protein activation cascade (GO:2000257)4.82127291
32regulation of fibrinolysis (GO:0051917)4.77572009
33bile acid metabolic process (GO:0008206)4.74447164
34aromatic amino acid family metabolic process (GO:0009072)4.71950704
35alpha-amino acid catabolic process (GO:1901606)4.67685922
36regulation of triglyceride catabolic process (GO:0010896)4.64618142
37omega-hydroxylase P450 pathway (GO:0097267)4.63155675
38amino-acid betaine metabolic process (GO:0006577)4.62993987
39epoxygenase P450 pathway (GO:0019373)4.56999229
40regulation of complement activation (GO:0030449)4.53124946
41tyrosine metabolic process (GO:0006570)4.53036818
42reverse cholesterol transport (GO:0043691)4.47159185
43cellular ketone body metabolic process (GO:0046950)4.45513554
44cellular amino acid catabolic process (GO:0009063)4.39616015
45regulation of cholesterol esterification (GO:0010872)4.37304215
46cellular modified amino acid catabolic process (GO:0042219)4.36296276
47coenzyme catabolic process (GO:0009109)4.36106115
48acylglycerol homeostasis (GO:0055090)4.33969383
49triglyceride homeostasis (GO:0070328)4.33969383
50glutamate metabolic process (GO:0006536)4.33572053
51protein-lipid complex remodeling (GO:0034368)4.33167829
52macromolecular complex remodeling (GO:0034367)4.33167829
53plasma lipoprotein particle remodeling (GO:0034369)4.33167829
54regulation of actin filament-based movement (GO:1903115)4.25637121
55negative regulation of sterol transport (GO:0032372)4.23377472
56negative regulation of cholesterol transport (GO:0032375)4.23377472
57glycine metabolic process (GO:0006544)4.18630848
58serine family amino acid metabolic process (GO:0009069)4.18505652
59ethanol oxidation (GO:0006069)4.13482836
60plasma lipoprotein particle clearance (GO:0034381)4.08835475
61indolalkylamine metabolic process (GO:0006586)4.08266814
62regulation of cardiac muscle cell contraction (GO:0086004)4.07888245
63cellular glucuronidation (GO:0052695)4.07104302
64dicarboxylic acid biosynthetic process (GO:0043650)4.06793090
65short-chain fatty acid metabolic process (GO:0046459)4.06129249
66phospholipid efflux (GO:0033700)4.05503953
67aspartate family amino acid catabolic process (GO:0009068)4.01659726
68amine catabolic process (GO:0009310)4.01473574
69cellular biogenic amine catabolic process (GO:0042402)4.01473574
70acetyl-CoA metabolic process (GO:0006084)4.01202713
71serine family amino acid biosynthetic process (GO:0009070)4.00568644
722-oxoglutarate metabolic process (GO:0006103)4.00488173
73ethanol metabolic process (GO:0006067)4.00332117
74bile acid and bile salt transport (GO:0015721)3.94125847
75benzene-containing compound metabolic process (GO:0042537)3.93125472
76carboxylic acid catabolic process (GO:0046395)3.89472793
77organic acid catabolic process (GO:0016054)3.89472793
78ketone body metabolic process (GO:1902224)3.86693486
79imidazole-containing compound metabolic process (GO:0052803)3.86237718
80drug catabolic process (GO:0042737)3.79270456
81fatty acid beta-oxidation (GO:0006635)3.75840341
82arginine metabolic process (GO:0006525)3.74771626
83cholesterol efflux (GO:0033344)3.73586695
84valine metabolic process (GO:0006573)3.69702034
85regulation of cholesterol homeostasis (GO:2000188)3.69544060
86fatty acid oxidation (GO:0019395)3.69528409
87glycogen catabolic process (GO:0005980)3.68970852
88monocarboxylic acid catabolic process (GO:0072329)3.67901229
89phospholipid homeostasis (GO:0055091)3.67129378
90regulation of bile acid biosynthetic process (GO:0070857)3.66348434
91positive regulation of lipid catabolic process (GO:0050996)3.66327793
92positive regulation of fatty acid beta-oxidation (GO:0032000)3.64329260
93lipid oxidation (GO:0034440)3.63384370
94low-density lipoprotein particle remodeling (GO:0034374)3.61771688
95glucuronate metabolic process (GO:0019585)3.60568008
96uronic acid metabolic process (GO:0006063)3.60568008
97blood coagulation, intrinsic pathway (GO:0007597)3.60381502
98fatty acid catabolic process (GO:0009062)3.60320523
99positive regulation of digestive system process (GO:0060456)3.58887915
100plasma lipoprotein particle assembly (GO:0034377)3.57179835
101regulation of plasminogen activation (GO:0010755)3.54293458
102positive regulation of triglyceride lipase activity (GO:0061365)3.53173637
103positive regulation of lipoprotein lipase activity (GO:0051006)3.53173637
104aldehyde catabolic process (GO:0046185)3.53166558
105fibrinolysis (GO:0042730)3.52626661
106negative regulation of lipase activity (GO:0060192)3.52199848
107carnitine metabolic process (GO:0009437)3.52144883
108cholesterol homeostasis (GO:0042632)3.51085159
109cofactor catabolic process (GO:0051187)3.50875688
110branched-chain amino acid catabolic process (GO:0009083)3.48701343
111sterol homeostasis (GO:0055092)3.46316589
112cytolysis (GO:0019835)3.46210471
113glucan catabolic process (GO:0009251)3.39922128
114regulation of sequestering of triglyceride (GO:0010889)3.34483533
115positive regulation of systemic arterial blood pressure (GO:0003084)3.30653805
116response to mercury ion (GO:0046689)3.27883339
117oxidative demethylation (GO:0070989)3.26753163
118drug metabolic process (GO:0017144)3.26680865
119regulation of oxidative phosphorylation (GO:0002082)3.20362955
120fatty acid homeostasis (GO:0055089)3.17274951
121creatine metabolic process (GO:0006600)3.17141124
122adrenergic receptor signaling pathway (GO:0071875)3.12743526
123cellular polysaccharide catabolic process (GO:0044247)3.10855274
124positive regulation of fatty acid biosynthetic process (GO:0045723)3.07328208
125fatty acid transmembrane transport (GO:1902001)3.05588433
126actin-myosin filament sliding (GO:0033275)2.95592788
127muscle filament sliding (GO:0030049)2.95592788
128response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.94386232
129protein activation cascade (GO:0072376)2.93829456
130negative regulation of hemostasis (GO:1900047)2.90730286
131negative regulation of blood coagulation (GO:0030195)2.90730286
132positive regulation of cardiac muscle cell differentiation (GO:2000727)2.87800238
133oxaloacetate metabolic process (GO:0006107)2.87353721
134triglyceride catabolic process (GO:0019433)2.84787097
135positive regulation of triglyceride metabolic process (GO:0090208)2.82118970
136NADH metabolic process (GO:0006734)2.80053671
137acylglycerol catabolic process (GO:0046464)2.78642498
138neutral lipid catabolic process (GO:0046461)2.78642498
139regulation of the force of heart contraction (GO:0002026)2.78369091
140positive regulation of muscle hypertrophy (GO:0014742)2.76972833
141positive regulation of cardiac muscle hypertrophy (GO:0010613)2.76972833
142polysaccharide catabolic process (GO:0000272)2.76822636
143carnitine shuttle (GO:0006853)2.73018175
144complement activation (GO:0006956)2.72801384
145opsonization (GO:0008228)2.71953655
146positive regulation of fatty acid metabolic process (GO:0045923)2.71703984
147regulation of fatty acid biosynthetic process (GO:0042304)2.68179904
148complement activation, classical pathway (GO:0006958)2.66318865
149positive regulation of hemostasis (GO:1900048)2.66317384
150positive regulation of blood coagulation (GO:0030194)2.66317384
151negative regulation of muscle contraction (GO:0045932)2.65159546

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.95039071
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.80109003
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.45070109
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.20350560
5EGR1_23403033_ChIP-Seq_LIVER_Mouse6.09375602
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.63171976
7* FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.04634125
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.45007705
9EZH2_22144423_ChIP-Seq_EOC_Human4.19274518
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.99350792
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.44554366
12* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.43970046
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.40858335
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.12120706
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01270879
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01270879
17* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.00596623
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.00038799
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.3023820
20RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.92507115
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.91659506
22CLOCK_20551151_ChIP-Seq_293T_Human1.87244576
23HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.81831019
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.78661303
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76222063
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74345187
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.67084482
28FOXA2_19822575_ChIP-Seq_HepG2_Human1.66783345
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65040610
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62639654
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.60490001
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.57106776
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.57001520
34DROSHA_22980978_ChIP-Seq_HELA_Human1.55548117
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.55482411
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.54308985
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53635082
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52699192
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46596937
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45539980
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.41705223
42HNF4A_19822575_ChIP-Seq_HepG2_Human1.36550991
43HTT_18923047_ChIP-ChIP_STHdh_Human1.34783666
44GATA1_22025678_ChIP-Seq_K562_Human1.32962223
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32209236
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.31553745
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.22762419
48AR_21572438_ChIP-Seq_LNCaP_Human1.21644631
49TP53_20018659_ChIP-ChIP_R1E_Mouse1.20787128
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20274442
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20228343
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.20038726
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17878168
54STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16927200
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.15939656
56NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14032097
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13805044
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12845862
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.10638862
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.09965476
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08976918
62RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08412752
63RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06701569
64SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04425214
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03487748
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02892552
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00423573
68ZNF263_19887448_ChIP-Seq_K562_Human0.98818815
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96681503
70ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95905022
71SMC4_20622854_ChIP-Seq_HELA_Human0.94153456
72KDM2B_26808549_Chip-Seq_K562_Human0.92754836
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91872685
74EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89987347
75SMC3_22415368_ChIP-Seq_MEFs_Mouse0.88896433
76ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88517828
77RARB_27405468_Chip-Seq_BRAIN_Mouse0.88037706
78RING1B_27294783_Chip-Seq_NPCs_Mouse0.86340689
79NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.84408089
80REST_21632747_ChIP-Seq_MESCs_Mouse0.84164126
81GATA4_25053715_ChIP-Seq_YYC3_Human0.84028284
82AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83406621
83ERG_21242973_ChIP-ChIP_JURKAT_Human0.81907978
84* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81705403
85SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80290896
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.79369650
87REST_18959480_ChIP-ChIP_MESCs_Mouse0.78792014
88ESR1_21235772_ChIP-Seq_MCF-7_Human0.77115981
89ZFP281_27345836_Chip-Seq_ESCs_Mouse0.76983502
90TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.76785173
91* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.76220529
92OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.76143645
93PIAS1_25552417_ChIP-Seq_VCAP_Human0.76033578
94KDM2B_26808549_Chip-Seq_SUP-B15_Human0.75882927
95LXR_22292898_ChIP-Seq_THP-1_Human0.75865243
96WT1_25993318_ChIP-Seq_PODOCYTE_Human0.75371263
97CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.74781870
98TP53_16413492_ChIP-PET_HCT116_Human0.73788931
99POU5F1_16518401_ChIP-PET_MESCs_Mouse0.73210152
100AR_19668381_ChIP-Seq_PC3_Human0.73121876
101SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71406013
102NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70384148
103NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70384148
104SA1_27219007_Chip-Seq_ERYTHROID_Human0.70216947
105* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70154236
106ESR1_20079471_ChIP-ChIP_T-47D_Human0.69049362
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.68401787
108RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67630892
109RARA_24833708_ChIP-Seq_LIVER_Mouse0.66651332
110IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.63961546
111TBX20_22080862_ChIP-Seq_HEART_Mouse0.63502382
112TBX20_22328084_ChIP-Seq_HEART_Mouse0.63502382
113STAT3_1855785_ChIP-Seq_MESCs_Mouse0.63496037
114BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62957363
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60016886
116CEBPB_22108803_ChIP-Seq_LS180_Human0.59729408
117PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.59581981
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.58398960
119FOXO3_23340844_ChIP-Seq_DLD1_Human0.58315275
120CDX2_20551321_ChIP-Seq_CACO-2_Human0.56295641
121Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.55535295
122PPAR_26484153_Chip-Seq_NCI-H1993_Human0.55451853
123MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.54781247
124RARB_24833708_ChIP-Seq_LIVER_Mouse0.54141074
125* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.54113989
126EGR1_19032775_ChIP-ChIP_M12_Human0.53921108
127CBP_21632823_ChIP-Seq_H3396_Human0.52962420
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.52568621
129KAP1_22055183_ChIP-Seq_ESCs_Mouse0.52494367
130* FOXA1_25552417_ChIP-Seq_VCAP_Human0.52167031
131ESET_19884257_ChIP-Seq_ESCs_Mouse0.51099353
132SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.50341374
133* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.49778115
134GATA1_19941826_ChIP-Seq_K562_Human0.49206622
135* MYC_19915707_ChIP-ChIP_AK7_Human0.49031579
136FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48416816
137BCAT_22108803_ChIP-Seq_LS180_Human0.47393369
138MYC_27129775_Chip-Seq_CORNEA_Mouse0.46838819
139RACK7_27058665_Chip-Seq_MCF-7_Human0.46825697
140CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.46674843
141TAF2_19829295_ChIP-Seq_ESCs_Human0.46632801
142GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.46349310
143P53_21459846_ChIP-Seq_SAOS-2_Human0.46055308
144AR_20517297_ChIP-Seq_VCAP_Human0.46044420
145RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.45774803
146* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45457281
147TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.45232414
148GATA6_25053715_ChIP-Seq_YYC3_Human0.45209632
149CTCF_27219007_Chip-Seq_Bcells_Human0.45149109
150GATA2_19941826_ChIP-Seq_K562_Human0.44710035
151TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.44322699
152PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44307335
153STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.44208505
154NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.44129418
155DNAJC2_21179169_ChIP-ChIP_NT2_Human0.43793567
156ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.43407218
157CREB1_26743006_Chip-Seq_LNCaP_Human0.43225300
158GATA3_24758297_ChIP-Seq_MCF-7_Human0.42263790
159SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.42152951

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.89631700
2MP0005360_urolithiasis7.29516736
3MP0005085_abnormal_gallbladder_physiolo6.14145479
4MP0005365_abnormal_bile_salt6.09153644
5MP0008875_abnormal_xenobiotic_pharmacok4.88052214
6MP0003806_abnormal_nucleotide_metabolis4.06736129
7MP0003252_abnormal_bile_duct3.73910714
8MP0010329_abnormal_lipoprotein_level3.52974376
9MP0005083_abnormal_biliary_tract3.12257403
10MP0009840_abnormal_foam_cell3.11337404
11MP0005171_absent_coat_pigmentation3.04525605
12MP0005332_abnormal_amino_acid3.02208453
13MP0003195_calcinosis2.80361936
14MP0001666_abnormal_nutrient_absorption2.72510827
15MP0000751_myopathy2.57768349
16MP0000749_muscle_degeneration2.49559084
17MP0004145_abnormal_muscle_electrophysio2.32225569
18MP0003191_abnormal_cellular_cholesterol2.21373784
19MP0002118_abnormal_lipid_homeostasis2.19572598
20MP0004019_abnormal_vitamin_homeostasis2.15861194
21MP0000609_abnormal_liver_physiology2.07270394
22MP0002138_abnormal_hepatobiliary_system1.88514161
23MP0005319_abnormal_enzyme/_coenzyme1.85404373
24MP0003880_abnormal_central_pattern1.82330625
25MP0003868_abnormal_feces_composition1.80544766
26MP0003879_abnormal_hair_cell1.64824911
27MP0000747_muscle_weakness1.63267811
28MP0002249_abnormal_larynx_morphology1.62229012
29MP0001764_abnormal_homeostasis1.60758109
30MP0005584_abnormal_enzyme/coenzyme_acti1.59967137
31MP0005503_abnormal_tendon_morphology1.59117547
32MP0004087_abnormal_muscle_fiber1.57391669
33MP0005670_abnormal_white_adipose1.49946834
34MP0005620_abnormal_muscle_contractility1.45683990
35MP0003136_yellow_coat_color1.45025119
36MP0002108_abnormal_muscle_morphology1.42590235
37MP0009643_abnormal_urine_homeostasis1.40987570
38MP0004084_abnormal_cardiac_muscle1.39581357
39MP0003705_abnormal_hypodermis_morpholog1.39317146
40MP0003186_abnormal_redox_activity1.35812213
41MP0005451_abnormal_body_composition1.33204492
42MP0004130_abnormal_muscle_cell1.31934205
43MP0003283_abnormal_digestive_organ1.30627950
44MP0002837_dystrophic_cardiac_calcinosis1.30405219
45MP0002972_abnormal_cardiac_muscle1.28922558
46MP0005369_muscle_phenotype1.26046469
47MP0004215_abnormal_myocardial_fiber1.25546492
48MP0001544_abnormal_cardiovascular_syste1.23683489
49MP0005385_cardiovascular_system_phenoty1.23683489
50MP0002106_abnormal_muscle_physiology1.22915348
51MP0001502_abnormal_circadian_rhythm1.20618503
52MP0000759_abnormal_skeletal_muscle1.20342339
53MP0003011_delayed_dark_adaptation1.17747165
54MP0009697_abnormal_copulation1.16335875
55MP0005647_abnormal_sex_gland1.14446787
56MP0005379_endocrine/exocrine_gland_phen1.12213599
57MP0002254_reproductive_system_inflammat1.11790888
58MP0003279_aneurysm1.09773598
59MP0003656_abnormal_erythrocyte_physiolo1.09710583
60MP0000598_abnormal_liver_morphology1.09239954
61MP0008438_abnormal_cutaneous_collagen1.08421844
62MP0002638_abnormal_pupillary_reflex1.08226166
63MP0006036_abnormal_mitochondrial_physio1.07326086
64MP0000604_amyloidosis1.00941468
65MP0003137_abnormal_impulse_conducting1.00832291
66MP0002064_seizures0.99140361
67MP0005636_abnormal_mineral_homeostasis0.96937398
68MP0002971_abnormal_brown_adipose0.95582021
69MP0005666_abnormal_adipose_tissue0.93431301
70MP0002078_abnormal_glucose_homeostasis0.92052050
71MP0009780_abnormal_chondrocyte_physiolo0.91396731
72MP0009764_decreased_sensitivity_to0.90981291
73MP0004270_analgesia0.90969086
74MP0002272_abnormal_nervous_system0.89298458
75MP0010630_abnormal_cardiac_muscle0.89012956
76MP0005535_abnormal_body_temperature0.88870368
77MP0001486_abnormal_startle_reflex0.88478285
78MP0009763_increased_sensitivity_to0.87960840
79MP0002295_abnormal_pulmonary_circulatio0.86970811
80MP0005423_abnormal_somatic_nervous0.85557444
81MP0003690_abnormal_glial_cell0.84844898
82MP0009642_abnormal_blood_homeostasis0.84737879
83MP0010368_abnormal_lymphatic_system0.84115616
84MP0001984_abnormal_olfaction0.83736530
85MP0001440_abnormal_grooming_behavior0.83710063
86MP0005334_abnormal_fat_pad0.83037974
87MP0005220_abnormal_exocrine_pancreas0.82181014
88MP0004233_abnormal_muscle_weight0.79937504
89MP0003329_amyloid_beta_deposits0.79792265
90MP0002876_abnormal_thyroid_physiology0.79517103
91MP0005376_homeostasis/metabolism_phenot0.79105036
92MP0001756_abnormal_urination0.78038582
93MP0005084_abnormal_gallbladder_morpholo0.77459593
94MP0004085_abnormal_heartbeat0.75141953
95MP0000372_irregular_coat_pigmentation0.74573226
96MP0005266_abnormal_metabolism0.74202895
97MP0001661_extended_life_span0.73693740
98MP0008469_abnormal_protein_level0.73148521
99MP0000750_abnormal_muscle_regeneration0.72628801
100MP0003635_abnormal_synaptic_transmissio0.71600197
101MP0004885_abnormal_endolymph0.71147894
102MP0001485_abnormal_pinna_reflex0.70982671
103MP0005646_abnormal_pituitary_gland0.70649325
104MP0004043_abnormal_pH_regulation0.70419177
105MP0004510_myositis0.70352721
106MP0000566_synostosis0.69065256
107MP0005187_abnormal_penis_morphology0.68386098
108MP0004859_abnormal_synaptic_plasticity0.67806889
109MP0009745_abnormal_behavioral_response0.67785192
110MP0005448_abnormal_energy_balance0.65489141
111MP0006035_abnormal_mitochondrial_morpho0.64475145
112MP0009765_abnormal_xenobiotic_induced0.63632406
113MP0005408_hypopigmentation0.63052380
114MP0003646_muscle_fatigue0.53766466
115MP0002136_abnormal_kidney_physiology0.53378096
116MP0002269_muscular_atrophy0.52717214
117MP0002822_catalepsy0.52529345
118MP0003638_abnormal_response/metabolism_0.52500908
119MP0005330_cardiomyopathy0.50567086
120MP0003953_abnormal_hormone_level0.50238790
121MP0000639_abnormal_adrenal_gland0.49541962
122MP0004185_abnormal_adipocyte_glucose0.48469538
123MP0000230_abnormal_systemic_arterial0.47563867
124MP0008874_decreased_physiological_sensi0.47563586
125MP0009115_abnormal_fat_cell0.46957394
126MP0003075_altered_response_to0.45201889
127MP0005375_adipose_tissue_phenotype0.43866547
128MP0009053_abnormal_anal_canal0.43383101
129MP0001765_abnormal_ion_homeostasis0.41941317
130MP0009384_cardiac_valve_regurgitation0.41886729
131MP0002970_abnormal_white_adipose0.40890715
132MP0002928_abnormal_bile_duct0.40844173
133MP0005395_other_phenotype0.40630386
134MP0009672_abnormal_birth_weight0.40536819
135MP0002796_impaired_skin_barrier0.40484958
136MP0003959_abnormal_lean_body0.38792211
137MP0005166_decreased_susceptibility_to0.37665467
138MP0002168_other_aberrant_phenotype0.37513730
139MP0008872_abnormal_physiological_respon0.36291052
140MP0005167_abnormal_blood-brain_barrier0.35981023
141MP0005058_abnormal_lysosome_morphology0.35496559
142MP0002332_abnormal_exercise_endurance0.33470978
143MP0004782_abnormal_surfactant_physiolog0.33463202
144MP0005248_abnormal_Harderian_gland0.32935658
145MP0000579_abnormal_nail_morphology0.32879218
146MP0008873_increased_physiological_sensi0.32333033
147MP0002090_abnormal_vision0.30072404
148MP0010234_abnormal_vibrissa_follicle0.29818003
149MP0006138_congestive_heart_failure0.29477171
150MP0008961_abnormal_basal_metabolism0.29465200
151MP0004036_abnormal_muscle_relaxation0.27520953

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.97304739
2Deep venous thrombosis (HP:0002625)6.70307823
3Intrahepatic cholestasis (HP:0001406)6.68008064
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.10367907
5Xanthomatosis (HP:0000991)6.04523378
6Prolonged partial thromboplastin time (HP:0003645)5.68660832
7Hypobetalipoproteinemia (HP:0003563)5.63208954
8Hyperlipoproteinemia (HP:0010980)5.30884259
9Complement deficiency (HP:0004431)4.99443146
10Calf muscle hypertrophy (HP:0008981)4.89695381
11Muscle hypertrophy of the lower extremities (HP:0008968)4.81908581
12Hyperammonemia (HP:0001987)4.81240936
13Ketosis (HP:0001946)4.75608524
14Hyperglycinemia (HP:0002154)4.67752444
15Hyperglycinuria (HP:0003108)4.65141157
16Hypolipoproteinemia (HP:0010981)4.51223296
17Abnormality of glycine metabolism (HP:0010895)4.49744886
18Abnormality of serine family amino acid metabolism (HP:0010894)4.49744886
19Muscle fiber inclusion bodies (HP:0100299)4.35308633
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.23409662
21Hypoalphalipoproteinemia (HP:0003233)4.21987015
22Epidermoid cyst (HP:0200040)4.20374605
23Abnormality of sulfur amino acid metabolism (HP:0004339)4.17391282
24Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.16307497
25Joint hemorrhage (HP:0005261)4.13809363
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.13502604
27Nemaline bodies (HP:0003798)4.08435354
28Hypoglycemic coma (HP:0001325)4.06764580
29Abnormality of aspartate family amino acid metabolism (HP:0010899)4.05290485
30Abnormality of methionine metabolism (HP:0010901)3.98778347
31Hyporeflexia of lower limbs (HP:0002600)3.94017531
32Abnormality of the common coagulation pathway (HP:0010990)3.90497627
33Fat malabsorption (HP:0002630)3.85099401
34Exercise-induced myalgia (HP:0003738)3.82156813
35Ketoacidosis (HP:0001993)3.78176252
36Type 1 muscle fiber predominance (HP:0003803)3.71170726
37Abnormality of fatty-acid metabolism (HP:0004359)3.70839169
38EMG: myopathic abnormalities (HP:0003458)3.61631178
39Muscle fiber splitting (HP:0003555)3.60612760
40Abnormality of complement system (HP:0005339)3.58090922
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.50296503
42Abnormality of the intrinsic pathway (HP:0010989)3.50201512
43Abnormality of the calf musculature (HP:0001430)3.42445735
44Abnormality of pyrimidine metabolism (HP:0004353)3.37996825
45Hypercholesterolemia (HP:0003124)3.33909230
46Gout (HP:0001997)3.25543479
47Conjugated hyperbilirubinemia (HP:0002908)3.23354206
48Delayed CNS myelination (HP:0002188)3.22511166
49Abnormality of serum amino acid levels (HP:0003112)3.18496342
50Neoplasm of the heart (HP:0100544)3.15832706
51Abnormality of nucleobase metabolism (HP:0010932)3.12858614
52Hyperbilirubinemia (HP:0002904)3.05143994
53Abnormality of purine metabolism (HP:0004352)3.00289508
54Steatorrhea (HP:0002570)2.97428815
55Metabolic acidosis (HP:0001942)2.94679459
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.92536498
57Dicarboxylic aciduria (HP:0003215)2.92536498
58Atrioventricular block (HP:0001678)2.90750111
59Bundle branch block (HP:0011710)2.89814338
60Heart block (HP:0012722)2.86569304
61Myocardial infarction (HP:0001658)2.84187968
62Hepatocellular carcinoma (HP:0001402)2.79012791
63Lethargy (HP:0001254)2.78596604
64Skin nodule (HP:0200036)2.78419577
65Frequent falls (HP:0002359)2.75043414
66EMG: neuropathic changes (HP:0003445)2.74683579
67Sudden death (HP:0001699)2.73584873
68Abnormality of the Achilles tendon (HP:0005109)2.72508540
69Anomalous pulmonary venous return (HP:0010772)2.70998885
70Abnormal atrioventricular conduction (HP:0005150)2.66293875
71Cerebral edema (HP:0002181)2.60413087
72Vascular calcification (HP:0004934)2.56938842
73Difficulty running (HP:0009046)2.53824557
74Abnormality of the pulmonary veins (HP:0011718)2.52516607
75Rhabdomyolysis (HP:0003201)2.52116099
76Exercise-induced muscle cramps (HP:0003710)2.51410271
77Spontaneous abortion (HP:0005268)2.48278813
78Hypochromic microcytic anemia (HP:0004840)2.46631645
79Hypoglycemic seizures (HP:0002173)2.46018579
80Systemic lupus erythematosus (HP:0002725)2.44069872
81Broad ribs (HP:0000885)2.43910925
82Death in childhood (HP:0003819)2.41986340
83Abnormal gallbladder morphology (HP:0012437)2.40749086
84Spastic diplegia (HP:0001264)2.40138465
85Cholelithiasis (HP:0001081)2.39701356
86Generalized aminoaciduria (HP:0002909)2.39169261
87Neonatal onset (HP:0003623)2.37660442
88Enlarged kidneys (HP:0000105)2.36242612
89Myopathic facies (HP:0002058)2.32818048
90Late onset (HP:0003584)2.32793831
91Irritability (HP:0000737)2.30998791
92Abnormality of the left ventricular outflow tract (HP:0011103)2.30749131
93Subaortic stenosis (HP:0001682)2.30749131
94Asymmetric septal hypertrophy (HP:0001670)2.29544098
95Vomiting (HP:0002013)2.29205038
96Cardiovascular calcification (HP:0011915)2.28364791
97Abnormality of the parietal bone (HP:0002696)2.27250175
98Pancreatitis (HP:0001733)2.26473397
99Deformed sella turcica (HP:0002681)2.24989519
100Malnutrition (HP:0004395)2.24610363
101Increased purine levels (HP:0004368)2.22983255
102Hyperuricemia (HP:0002149)2.22983255
103Increased variability in muscle fiber diameter (HP:0003557)2.22868093
104Achilles tendon contracture (HP:0001771)2.22703512
105Sensorimotor neuropathy (HP:0007141)2.22675196
106Hyperinsulinemic hypoglycemia (HP:0000825)2.20133665
107Abnormality of skeletal muscle fiber size (HP:0012084)2.18527619
108Abnormality of proline metabolism (HP:0010907)2.16983907
109Hydroxyprolinuria (HP:0003080)2.16983907
110Mitral stenosis (HP:0001718)2.15833719
111Difficulty climbing stairs (HP:0003551)2.14852457
112Supernumerary ribs (HP:0005815)2.13264066
113Nephritis (HP:0000123)2.13000580
114Centrally nucleated skeletal muscle fibers (HP:0003687)2.12691907
115Proximal tubulopathy (HP:0000114)2.11845652
116Amyloidosis (HP:0011034)2.11675001
117Abnormal gallbladder physiology (HP:0012438)2.10738725
118Cholecystitis (HP:0001082)2.10738725
119Esophageal varix (HP:0002040)2.09140265
120Abnormality of the 4th metacarpal (HP:0010012)2.08862033
121Myoglobinuria (HP:0002913)2.05476355
122Brushfield spots (HP:0001088)2.05107272
123Arterial tortuosity (HP:0005116)2.04685252
124Obstructive sleep apnea (HP:0002870)2.04496817
125Neck muscle weakness (HP:0000467)2.02943240
126Glomerulonephritis (HP:0000099)2.00791610
127Alkalosis (HP:0001948)2.00507356
128Oligomenorrhea (HP:0000876)1.99823080
129Acanthocytosis (HP:0001927)1.99568921
130Distal lower limb muscle weakness (HP:0009053)1.99127398
131Short 4th metacarpal (HP:0010044)1.98881873
132Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.98881873
133Abnormal cartilage morphology (HP:0002763)1.96468635
134Distal arthrogryposis (HP:0005684)1.95838218
135Supernumerary bones of the axial skeleton (HP:0009144)1.95015428
136Hemorrhage of the eye (HP:0011885)1.93422404
137Increased connective tissue (HP:0009025)1.93422194
138Opisthotonus (HP:0002179)1.93281468
139Areflexia of lower limbs (HP:0002522)1.92793362
140Rimmed vacuoles (HP:0003805)1.92782249
141Abnormality of the gallbladder (HP:0005264)1.92100154
142Hyperglycemia (HP:0003074)1.91662200
143Limb-girdle muscle atrophy (HP:0003797)1.89900941
144Status epilepticus (HP:0002133)1.89703606
145Dilated cardiomyopathy (HP:0001644)1.89431330
146Round ear (HP:0100830)1.89170921
147Vascular tortuosity (HP:0004948)1.88320389
148Rickets (HP:0002748)1.84483704
149Recurrent gram-negative bacterial infections (HP:0005420)1.84084431
150Vertebral fusion (HP:0002948)1.82610032
151Hemivertebrae (HP:0002937)1.82444981
152Abnormal finger flexion creases (HP:0006143)1.80477268
153Generalized muscle weakness (HP:0003324)1.79743614
154Neonatal hypoglycemia (HP:0001998)1.78531006
155Renal cortical cysts (HP:0000803)1.77865597
156Thrombophlebitis (HP:0004418)1.76904872
157Abnormal enzyme/coenzyme activity (HP:0012379)1.74458810
158Hypertriglyceridemia (HP:0002155)1.74403997
159Abnormality of urine glucose concentration (HP:0011016)1.74227901
160Glycosuria (HP:0003076)1.74227901
161Menorrhagia (HP:0000132)1.73258142
162Hypothermia (HP:0002045)1.73053807
163Abnormality of vitamin metabolism (HP:0100508)1.72911780
164Spontaneous hematomas (HP:0007420)1.71901258
165Myotonia (HP:0002486)1.68142653
166Hemiplegia (HP:0002301)1.66813845
167Skin pits (HP:0100276)1.66060726

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.51550572
2SIK14.39664106
3ERN13.99675181
4FGFR43.56148495
5TRIB32.91953688
6INSRR2.75806765
7PKN22.36566993
8MAP2K42.06957212
9ERBB42.04749728
10TAOK31.98231405
11PINK11.88563071
12NTRK31.80263695
13MST1R1.72657457
14PRPF4B1.60691843
15MARK11.60453633
16MAPK111.57505691
17LATS11.57192413
18EEF2K1.51437843
19PDK31.48707428
20PDK41.48707428
21PRKCH1.45965273
22FLT31.44704363
23TNIK1.37823533
24STK41.37150060
25FRK1.36433776
26PIK3CG1.35309802
27PTK61.33535672
28LMTK21.33037972
29MAP3K71.32214481
30DAPK21.29094258
31CAMK11.28526597
32RIPK11.26602069
33PHKG21.21719711
34PHKG11.21719711
35PRKAA21.20817664
36FGFR21.18144084
37CAMK1D1.14863949
38STK38L1.12992876
39MUSK1.10055263
40ABL21.00797674
41MAPKAPK31.00428582
42MAPK120.99649427
43VRK10.97977292
44JAK20.97641068
45PDK20.97285328
46DAPK30.96587047
47EPHA40.95697198
48NEK90.94328538
49MAP2K30.94139218
50TIE10.93944173
51TYK20.91857017
52TLK10.90713881
53TTN0.88474907
54SGK30.88348947
55WNK40.88030456
56EPHB10.87850359
57UHMK10.87627034
58NTRK20.87559164
59PRKCG0.87292874
60PRKAA10.87067774
61PRKD30.86844633
62OBSCN0.86662896
63MET0.84420033
64ZAK0.82808914
65CAMK2G0.81753626
66CAMK2B0.80275255
67NEK10.79856990
68SGK10.78430903
69MARK20.77631380
70PAK60.77542587
71MAP3K30.76996254
72ERBB20.76393465
73PRKCZ0.75611994
74PRKACG0.75348135
75AKT20.74314241
76MAP3K40.74102119
77CAMK2D0.73226603
78JAK10.72883720
79DMPK0.72642123
80GRK60.71479030
81PTK2B0.71404029
82MYLK0.70284505
83SGK4940.70258288
84SGK2230.70258288
85SGK20.69696281
86KDR0.69639713
87PIK3CA0.68694157
88MAPK40.68237217
89CAMK1G0.67140932
90PDPK10.67008410
91ROCK10.64522842
92RPS6KA30.64220615
93GSK3A0.64188900
94RPS6KC10.63938958
95RPS6KL10.63938958
96PRKG10.63060917
97TYRO30.62617399
98MAP2K60.58884070
99MAPK150.58194062
100ICK0.57426406
101ARAF0.56829926
102CDK60.56269722
103PRKACA0.55167258
104RPS6KA60.55139773
105TNK20.55126323
106PRKCI0.54916324
107STK380.54425987
108WNK30.54297789
109MAP2K10.52989372
110IRAK30.52640810
111AKT30.52101079
112EPHA30.51903973
113TRPM70.51701416
114MAP2K70.50875211
115MAPK100.50870832
116MAPK70.50402972
117DYRK1B0.49935839
118RPS6KA50.49621321
119PAK30.48398439
120MAP3K110.48169556
121MAP3K10.48014712
122FGFR30.47701254
123CAMK2A0.47084701
124PTK20.46888127
125TBK10.46526053
126RET0.45961994
127TGFBR20.45248273
128PDGFRA0.43907292
129OXSR10.42798813
130MTOR0.42557331
131PDK10.42287451
132MAPKAPK50.41990809
133PNCK0.41850792
134LATS20.41734556
135MAP3K100.41124288
136PRKG20.40557144
137SMG10.40344826
138PKN10.37976678
139PRKD10.37555914
140CAMK40.37444526
141CSK0.35545371
142IRAK20.33052857
143MAP2K20.32045071
144TAOK20.31951348
145IGF1R0.31742764
146FER0.31715012
147BMX0.31102904
148PRKCQ0.30861903

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.14043299
2Nitrogen metabolism_Homo sapiens_hsa009103.69133847
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.44058561
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.13254484
5Arginine biosynthesis_Homo sapiens_hsa002203.02151037
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.71732772
7Fatty acid degradation_Homo sapiens_hsa000712.68247723
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.67718632
9Tryptophan metabolism_Homo sapiens_hsa003802.62713648
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.57548912
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.51021443
12Complement and coagulation cascades_Homo sapiens_hsa046102.40124430
13Propanoate metabolism_Homo sapiens_hsa006402.34486036
14Butanoate metabolism_Homo sapiens_hsa006502.28707640
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.12806636
16Peroxisome_Homo sapiens_hsa041462.08397541
17Fatty acid metabolism_Homo sapiens_hsa012122.02288860
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.00354040
19PPAR signaling pathway_Homo sapiens_hsa033201.97953476
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.93832809
21Systemic lupus erythematosus_Homo sapiens_hsa053221.79984111
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.77202102
23beta-Alanine metabolism_Homo sapiens_hsa004101.76137159
24Chemical carcinogenesis_Homo sapiens_hsa052041.74636095
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.72801312
26Histidine metabolism_Homo sapiens_hsa003401.69089583
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.68076518
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67366770
29Caffeine metabolism_Homo sapiens_hsa002321.59249265
30Pyruvate metabolism_Homo sapiens_hsa006201.55239124
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54695605
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.52004692
33Phenylalanine metabolism_Homo sapiens_hsa003601.51418219
34Bile secretion_Homo sapiens_hsa049761.49257457
35Retinol metabolism_Homo sapiens_hsa008301.47983004
36Selenocompound metabolism_Homo sapiens_hsa004501.45804725
37Staphylococcus aureus infection_Homo sapiens_hsa051501.41502899
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35733551
39Sulfur metabolism_Homo sapiens_hsa009201.35154992
40Tyrosine metabolism_Homo sapiens_hsa003501.34413153
41Starch and sucrose metabolism_Homo sapiens_hsa005001.33932655
42Carbon metabolism_Homo sapiens_hsa012001.33672158
43Biosynthesis of amino acids_Homo sapiens_hsa012301.33613936
44Fatty acid elongation_Homo sapiens_hsa000621.30581225
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.29691892
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.25924877
47Fat digestion and absorption_Homo sapiens_hsa049751.22569471
48Dilated cardiomyopathy_Homo sapiens_hsa054141.22313363
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15898879
50Folate biosynthesis_Homo sapiens_hsa007901.13592419
51ABC transporters_Homo sapiens_hsa020101.11747524
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10243610
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06687744
54Alcoholism_Homo sapiens_hsa050341.05880257
55Cyanoamino acid metabolism_Homo sapiens_hsa004601.05579959
56Arginine and proline metabolism_Homo sapiens_hsa003301.04251968
57Steroid biosynthesis_Homo sapiens_hsa001000.97987337
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.91747449
59Sulfur relay system_Homo sapiens_hsa041220.90691971
60Lysine degradation_Homo sapiens_hsa003100.88941989
61Vitamin B6 metabolism_Homo sapiens_hsa007500.86657210
62Glycerolipid metabolism_Homo sapiens_hsa005610.85578536
63Renin secretion_Homo sapiens_hsa049240.84992774
64Vitamin digestion and absorption_Homo sapiens_hsa049770.83837739
65Fatty acid biosynthesis_Homo sapiens_hsa000610.83163812
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82471478
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81558792
68Cardiac muscle contraction_Homo sapiens_hsa042600.81058562
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77487030
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77475580
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76494473
72Insulin secretion_Homo sapiens_hsa049110.63693739
73Glutathione metabolism_Homo sapiens_hsa004800.62506742
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55983783
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.55281758
76Pentose phosphate pathway_Homo sapiens_hsa000300.54362084
77One carbon pool by folate_Homo sapiens_hsa006700.53372239
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50066366
79Calcium signaling pathway_Homo sapiens_hsa040200.48394472
80Basal cell carcinoma_Homo sapiens_hsa052170.47935478
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46662363
82Metabolic pathways_Homo sapiens_hsa011000.46496595
83cAMP signaling pathway_Homo sapiens_hsa040240.45070066
84Amphetamine addiction_Homo sapiens_hsa050310.42656794
85Fructose and mannose metabolism_Homo sapiens_hsa000510.36909573
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.36762351
87Insulin resistance_Homo sapiens_hsa049310.36453178
88Circadian entrainment_Homo sapiens_hsa047130.36163591
89Cocaine addiction_Homo sapiens_hsa050300.34370024
90Prion diseases_Homo sapiens_hsa050200.33318294
91Salivary secretion_Homo sapiens_hsa049700.31782638
92GABAergic synapse_Homo sapiens_hsa047270.31684423
93Galactose metabolism_Homo sapiens_hsa000520.31498470
94Glutamatergic synapse_Homo sapiens_hsa047240.28836092
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27399276
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25901754
97Glucagon signaling pathway_Homo sapiens_hsa049220.25301900
98Hedgehog signaling pathway_Homo sapiens_hsa043400.24828317
99Mineral absorption_Homo sapiens_hsa049780.24367872
100Oxytocin signaling pathway_Homo sapiens_hsa049210.24040317
101Gastric acid secretion_Homo sapiens_hsa049710.23729461
102Gap junction_Homo sapiens_hsa045400.23650595
103Melanogenesis_Homo sapiens_hsa049160.23359285
104Long-term potentiation_Homo sapiens_hsa047200.22314528
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.18800096
106Linoleic acid metabolism_Homo sapiens_hsa005910.17600554
107AMPK signaling pathway_Homo sapiens_hsa041520.16815101
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07452704
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06793147
110Insulin signaling pathway_Homo sapiens_hsa049100.02572063
111Type II diabetes mellitus_Homo sapiens_hsa04930-0.1984747
112Circadian rhythm_Homo sapiens_hsa04710-0.1766540
113Pancreatic secretion_Homo sapiens_hsa04972-0.1658377
114Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1643184
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1635579
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1582256
117Renin-angiotensin system_Homo sapiens_hsa04614-0.1534999
118Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1411268
119African trypanosomiasis_Homo sapiens_hsa05143-0.1404117
120Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1344050
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1329327
122Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1319823
123Regulation of autophagy_Homo sapiens_hsa04140-0.1171454
124Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1060764
125Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1047794
126Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0919397
127Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0853424
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0800750
129Protein digestion and absorption_Homo sapiens_hsa04974-0.0664378

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