KLF16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.08379984
2histone H4-K12 acetylation (GO:0043983)4.53521949
3protein localization to kinetochore (GO:0034501)4.45930821
4regulation of translational termination (GO:0006449)4.27259749
5protein localization to endosome (GO:0036010)4.24563119
6mitotic sister chromatid segregation (GO:0000070)4.22974969
7pre-miRNA processing (GO:0031054)4.16862676
8ribosome biogenesis (GO:0042254)4.13730890
9formation of translation preinitiation complex (GO:0001731)4.11698938
10regulation of gene silencing by RNA (GO:0060966)3.98581811
11regulation of posttranscriptional gene silencing (GO:0060147)3.98581811
12regulation of gene silencing by miRNA (GO:0060964)3.98581811
13mitotic nuclear envelope disassembly (GO:0007077)3.97115473
14heterochromatin organization (GO:0070828)3.91387314
15response to peptidoglycan (GO:0032494)3.88407095
16nuclear envelope disassembly (GO:0051081)3.80459533
17membrane disassembly (GO:0030397)3.80459533
18peptidyl-arginine omega-N-methylation (GO:0035247)3.69264510
19mitotic G1 DNA damage checkpoint (GO:0031571)3.67934914
20DNA deamination (GO:0045006)3.62268056
21protein localization to chromosome, centromeric region (GO:0071459)3.62260935
22nuclear pore organization (GO:0006999)3.62257619
23nuclear pore complex assembly (GO:0051292)3.58360212
24regulation of translational fidelity (GO:0006450)3.58332018
25modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.57204896
26positive regulation by organism of defense response of other organism involved in symbiotic interact3.57204896
27modulation by symbiont of host immune response (GO:0052553)3.57204896
28positive regulation by symbiont of host defense response (GO:0052509)3.57204896
29modulation by symbiont of host defense response (GO:0052031)3.57204896
30modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.57204896
31sister chromatid segregation (GO:0000819)3.54445152
32histone arginine methylation (GO:0034969)3.53473312
33DNA replication initiation (GO:0006270)3.47101884
34transcription from mitochondrial promoter (GO:0006390)3.46961872
35pinocytosis (GO:0006907)3.42719038
36DNA replication-dependent nucleosome assembly (GO:0006335)3.41568002
37DNA replication-dependent nucleosome organization (GO:0034723)3.41568002
38modulation by symbiont of host cellular process (GO:0044068)3.41197193
39mitotic metaphase plate congression (GO:0007080)3.41149239
40modulation by virus of host process (GO:0019054)3.40602404
41mannose metabolic process (GO:0006013)3.39604286
42intracellular estrogen receptor signaling pathway (GO:0030520)3.37571443
43maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.37524099
44regulation of mammary gland epithelial cell proliferation (GO:0033599)3.36189028
453-UTR-mediated mRNA stabilization (GO:0070935)3.35438048
46regulation of hippo signaling (GO:0035330)3.34591686
47DNA strand elongation involved in DNA replication (GO:0006271)3.33407593
48negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.33137739
49nodal signaling pathway (GO:0038092)3.33068591
50somatic diversification of immune receptors via somatic mutation (GO:0002566)3.32835738
51somatic hypermutation of immunoglobulin genes (GO:0016446)3.32835738
52negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.32341474
53peptidyl-arginine methylation (GO:0018216)3.31217584
54peptidyl-arginine N-methylation (GO:0035246)3.31217584
55apoptotic process involved in morphogenesis (GO:0060561)3.29235387
56DNA unwinding involved in DNA replication (GO:0006268)3.29016167
57mitotic G1/S transition checkpoint (GO:0044819)3.26944893
58embryonic process involved in female pregnancy (GO:0060136)3.26687816
59replication fork processing (GO:0031297)3.26487901
60folic acid-containing compound biosynthetic process (GO:0009396)3.24434464
61DNA replication checkpoint (GO:0000076)3.23298248
62proline biosynthetic process (GO:0006561)3.20620599
63stress fiber assembly (GO:0043149)3.18291534
64G1 DNA damage checkpoint (GO:0044783)3.16395040
65histone H4-K5 acetylation (GO:0043981)3.16005130
66histone H4-K8 acetylation (GO:0043982)3.16005130
67regulation of leukocyte degranulation (GO:0043300)3.15606983
68negative regulation of histone methylation (GO:0031061)3.14899180
69establishment of apical/basal cell polarity (GO:0035089)3.14682079
70IMP biosynthetic process (GO:0006188)3.14395682
71nuclear envelope organization (GO:0006998)3.13884900
72activation of Rac GTPase activity (GO:0032863)3.13774472
73barbed-end actin filament capping (GO:0051016)3.13214204
74DNA strand elongation (GO:0022616)3.12889709
75trophectodermal cell differentiation (GO:0001829)3.10280643
76telomere maintenance via semi-conservative replication (GO:0032201)3.09584557
77NIK/NF-kappaB signaling (GO:0038061)3.09461306
78response to muramyl dipeptide (GO:0032495)3.08243023
79dosage compensation (GO:0007549)3.05463076
80pentose-phosphate shunt (GO:0006098)3.05349843
81response to laminar fluid shear stress (GO:0034616)3.05252499
82DNA duplex unwinding (GO:0032508)3.05085779
83regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04897422
84DNA geometric change (GO:0032392)3.01561246
85spliceosomal tri-snRNP complex assembly (GO:0000244)2.98861900
86positive regulation of Cdc42 GTPase activity (GO:0043089)2.98774254
87Golgi transport vesicle coating (GO:0048200)2.96777557
88COPI coating of Golgi vesicle (GO:0048205)2.96777557
89positive regulation of chromosome segregation (GO:0051984)2.96150294
90nucleobase biosynthetic process (GO:0046112)2.93560989
91regulation of double-strand break repair via homologous recombination (GO:0010569)2.93160856
92chromatin assembly (GO:0031497)2.92483005
93ribonucleoprotein complex biogenesis (GO:0022613)2.92237482
94regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.90766303
95lipopolysaccharide-mediated signaling pathway (GO:0031663)2.88931499
96positive regulation of protein homooligomerization (GO:0032464)2.88179123
97mitochondrial DNA metabolic process (GO:0032042)2.87721478
98regulation of myeloid leukocyte mediated immunity (GO:0002886)2.87031110
99mRNA transport (GO:0051028)2.84052803
100adherens junction assembly (GO:0034333)2.83509699
101pseudouridine synthesis (GO:0001522)2.83262993
102rRNA transcription (GO:0009303)2.82960318
103neutrophil activation involved in immune response (GO:0002283)2.81669458
104mitotic chromosome condensation (GO:0007076)2.81528261
105cell-substrate adherens junction assembly (GO:0007045)2.80476946
106focal adhesion assembly (GO:0048041)2.80476946
107negative regulation of mRNA processing (GO:0050686)2.80150468
108regulation of double-strand break repair (GO:2000779)2.79651721
109negative regulation of RNA splicing (GO:0033119)2.79514400
110regulation of superoxide anion generation (GO:0032928)2.76549533
111establishment of monopolar cell polarity (GO:0061162)2.74957553
112establishment or maintenance of monopolar cell polarity (GO:0061339)2.74957553
113protein retention in ER lumen (GO:0006621)2.74877347
114macrophage activation involved in immune response (GO:0002281)2.74199099
115maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.73523668
116regulation of T-helper 2 cell differentiation (GO:0045628)2.73074255
117maturation of 5.8S rRNA (GO:0000460)2.72327452
118regulation of RNA export from nucleus (GO:0046831)2.70828071
119regulation of mast cell degranulation (GO:0043304)2.70476994
120regulation of early endosome to late endosome transport (GO:2000641)2.70425959
121IMP metabolic process (GO:0046040)2.69068143
122positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.68576438
123DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.66943901
124metaphase plate congression (GO:0051310)2.65323947
125positive regulation of protein dephosphorylation (GO:0035307)2.64816126
126histone H2A monoubiquitination (GO:0035518)2.63576819
127mRNA cleavage (GO:0006379)2.62829437
128regulation of regulated secretory pathway (GO:1903305)2.62650343
129regulation of sister chromatid cohesion (GO:0007063)2.61989872
130positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.61632465
131glucose catabolic process (GO:0006007)2.61240126
132negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.61236423
133negative regulation of cell killing (GO:0031342)2.61236423
134cell-substrate junction assembly (GO:0007044)2.61189143
135regulation of nuclear cell cycle DNA replication (GO:0033262)2.61018098
136rRNA processing (GO:0006364)2.60894101
137antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.60864947
138antigen processing and presentation of endogenous antigen (GO:0019883)2.60710498
139histone H4-K16 acetylation (GO:0043984)2.60643022
140base-excision repair (GO:0006284)2.60576413
141pore complex assembly (GO:0046931)2.59360591
142activation of MAPKKK activity (GO:0000185)2.59140139
143negative regulation of cell size (GO:0045792)2.58205504
144ribosome assembly (GO:0042255)2.57728068
145DNA damage response, signal transduction resulting in transcription (GO:0042772)2.56475311
146positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.55957203
147positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.55957203
148positive regulation of mitotic sister chromatid separation (GO:1901970)2.55957203
149protein complex localization (GO:0031503)2.54722571
150rRNA metabolic process (GO:0016072)2.54580410
151nucleic acid transport (GO:0050657)2.54368971
152establishment of RNA localization (GO:0051236)2.54368971
153positive thymic T cell selection (GO:0045059)2.53658693
154regulation of defense response to virus by virus (GO:0050690)2.52133131
155detection of bacterium (GO:0016045)2.51272793
156positive regulation of gamma-delta T cell activation (GO:0046645)2.51047778
157detection of other organism (GO:0098543)2.50722066
158signal complex assembly (GO:0007172)2.50442008
159glucose 6-phosphate metabolic process (GO:0051156)2.49824089
160antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.48097671
161NADPH regeneration (GO:0006740)2.47586048
162regulation of extracellular matrix disassembly (GO:0010715)2.45400092
163maternal placenta development (GO:0001893)2.43953321
164negative regulation of phagocytosis (GO:0050765)2.42740157
165regulation of type I interferon-mediated signaling pathway (GO:0060338)2.41075714
166modulation by virus of host morphology or physiology (GO:0019048)2.40306788
167skin morphogenesis (GO:0043589)2.39978300
168cytoskeletal anchoring at plasma membrane (GO:0007016)2.39912211
169negative regulation of toll-like receptor signaling pathway (GO:0034122)2.39320871
170thymic T cell selection (GO:0045061)2.38331658
171regulation of chromatin binding (GO:0035561)2.36130613
172negative regulation of interleukin-12 production (GO:0032695)2.35700890
173epithelial cell differentiation involved in prostate gland development (GO:0060742)2.35609676
174positive regulation of blood vessel endothelial cell migration (GO:0043536)2.33458021
175regulation of NFAT protein import into nucleus (GO:0051532)2.33287011
176response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.31573232
177response to host (GO:0075136)2.31573232
178response to host defenses (GO:0052200)2.31573232
179leukocyte aggregation (GO:0070486)2.31196506
180negative regulation of viral release from host cell (GO:1902187)2.30122708
181mRNA stabilization (GO:0048255)2.28358244
182RNA stabilization (GO:0043489)2.28358244
183activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.26532451
184regulation of interferon-beta biosynthetic process (GO:0045357)2.26421109
185cellular response to virus (GO:0098586)2.26108484
186regulation of mast cell activation involved in immune response (GO:0033006)2.26047608
187regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.24270849
188hyaluronan catabolic process (GO:0030214)2.24251835
189immunoglobulin mediated immune response (GO:0016064)2.23030101
190activation of JUN kinase activity (GO:0007257)2.22887610
191cell-cell junction maintenance (GO:0045217)2.22593932
192positive regulation of nuclease activity (GO:0032075)2.20175687
193G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.20142033
194UV protection (GO:0009650)2.20041651
195retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.19779937
196response to host immune response (GO:0052572)2.18812556

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.79749534
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.65999774
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.36911286
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21346947
5* MYC_22102868_ChIP-Seq_BL_Human3.01165667
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79558145
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.59745780
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.50307936
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.44656108
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.38982745
11* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.38895264
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.35314376
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31513145
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31075504
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.19554188
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.19554188
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.19554188
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17469755
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.09553776
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.07953700
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.05539100
22* VDR_24763502_ChIP-Seq_THP-1_Human1.99835080
23VDR_21846776_ChIP-Seq_THP-1_Human1.92760958
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80319065
25* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.74743858
26NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71487525
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69358374
28SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.69133919
29XRN2_22483619_ChIP-Seq_HELA_Human1.69088999
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.69088783
31* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.68274613
32* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.67434029
33* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.61028754
34* KDM2B_26808549_Chip-Seq_DND41_Human1.60523144
35* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60306776
36* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.58764635
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.57622794
38TCF7_22412390_ChIP-Seq_EML_Mouse1.57065666
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56271525
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56075484
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55949349
42CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.55850556
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.54622182
44* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54022810
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.53636688
46* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52520119
47* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.52253724
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50670891
49* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50269824
50* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.49661354
51MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.48326599
52CTCF_27219007_Chip-Seq_ERYTHROID_Human1.46676009
53UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.45393224
54* P68_20966046_ChIP-Seq_HELA_Human1.45128877
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.43100817
56SA1_27219007_Chip-Seq_ERYTHROID_Human1.42556110
57MAF_26560356_Chip-Seq_TH2_Human1.42546411
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.42298845
59* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42093846
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41449844
61CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.41401036
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41324754
63* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40211772
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37757708
65KDM5A_27292631_Chip-Seq_BREAST_Human1.37466008
66* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37374616
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37317771
68SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.37278752
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37029306
70NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36954811
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36549834
72* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35981275
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35543269
74NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.34904793
75GABP_19822575_ChIP-Seq_HepG2_Human1.32977689
76* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32910097
77NANOG_21062744_ChIP-ChIP_HESCs_Human1.31970871
78* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31552670
79ZNF263_19887448_ChIP-Seq_K562_Human1.31439661
80LXR_22292898_ChIP-Seq_THP-1_Human1.30682782
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28787031
82P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28469241
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28377329
84* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28362927
85KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28195116
86TCF3_18692474_ChIP-Seq_MEFs_Mouse1.27824642
87* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27468325
88NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.26944293
89* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25749871
90MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24907197
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.23593517
92RACK7_27058665_Chip-Seq_MCF-7_Human1.23398096
93YY1_21170310_ChIP-Seq_MESCs_Mouse1.22758010
94TCF3_18692474_ChIP-Seq_MESCs_Mouse1.22320406
95CIITA_25753668_ChIP-Seq_RAJI_Human1.20435359
96TTF2_22483619_ChIP-Seq_HELA_Human1.20422311
97SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19623166
98CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19250821
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19100423
100AR_21909140_ChIP-Seq_LNCAP_Human1.18435892
101ATF3_27146783_Chip-Seq_COLON_Human1.18417941
102CREB1_26743006_Chip-Seq_LNCaP_Human1.18164522
103POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17306832
104* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16842260
105POU5F1_16518401_ChIP-PET_MESCs_Mouse1.16688293
106TP63_19390658_ChIP-ChIP_HaCaT_Human1.16661404
107SMC4_20622854_ChIP-Seq_HELA_Human1.15802847
108* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15500294
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14851193
110ERG_21242973_ChIP-ChIP_JURKAT_Human1.14829784
111EST1_17652178_ChIP-ChIP_JURKAT_Human1.14582632
112SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14485721
113* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11995508
114KDM2B_26808549_Chip-Seq_K562_Human1.11676732
115CLOCK_20551151_ChIP-Seq_293T_Human1.11660001
116* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11402753
117* BCOR_27268052_Chip-Seq_Bcells_Human1.11239983
118SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10540864
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09790626
120PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08985479
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07854435
122* NCOR1_26117541_ChIP-Seq_K562_Human1.07206257
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07176532
124VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07175378
125SCL_19346495_ChIP-Seq_HPC-7_Human1.07059413
126NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06780930
127STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06006192
128POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.05689161
129VDR_23849224_ChIP-Seq_CD4+_Human1.05258455
130* SPI1_23127762_ChIP-Seq_K562_Human1.05249720
131ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05037718
132CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04967563
133ESR2_21235772_ChIP-Seq_MCF-7_Human1.04675393
134* SPI1_23547873_ChIP-Seq_NB4_Human1.03814300
135* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03513184
136GATA1_19941827_ChIP-Seq_MEL_Mouse1.03362514
137CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03037866
138TFEB_21752829_ChIP-Seq_HELA_Human1.02925390
139MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01955022
140OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01753293
141CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01696393
142BP1_19119308_ChIP-ChIP_Hs578T_Human1.01691821
143TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01550505
144KDM2B_26808549_Chip-Seq_JURKAT_Human1.01389963
145BCL6_27268052_Chip-Seq_Bcells_Human1.01283631
146* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00569956
147UTX_26944678_Chip-Seq_JUKART_Human1.00427795
148* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99652584
149DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99248100
150SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99043671
151SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98863574
152TET1_21451524_ChIP-Seq_MESCs_Mouse0.98829635
153TP53_22127205_ChIP-Seq_IMR90_Human0.98012560
154* MAF_26560356_Chip-Seq_TH1_Human0.97692892
155TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97513833
156ELF1_20517297_ChIP-Seq_JURKAT_Human0.96610147
157SOX2_18692474_ChIP-Seq_MESCs_Mouse0.96088445

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.84931164
2MP0003111_abnormal_nucleus_morphology3.81108757
3MP0004957_abnormal_blastocyst_morpholog3.68199758
4MP0003693_abnormal_embryo_hatching3.61192877
5MP0010094_abnormal_chromosome_stability3.31006708
6MP0005058_abnormal_lysosome_morphology3.16499781
7MP0005451_abnormal_body_composition3.12812111
8MP0003436_decreased_susceptibility_to3.02944282
9MP0003077_abnormal_cell_cycle3.00608672
10MP0010352_gastrointestinal_tract_polyps2.89351206
11MP0008260_abnormal_autophagy2.55074292
12MP0009840_abnormal_foam_cell2.49357666
13MP0003172_abnormal_lysosome_physiology2.43223859
14MP0004859_abnormal_synaptic_plasticity2.38602292
15MP0000350_abnormal_cell_proliferation2.37126351
16MP0003191_abnormal_cellular_cholesterol2.35181151
17MP0003705_abnormal_hypodermis_morpholog2.33099812
18MP0002653_abnormal_ependyma_morphology2.31310155
19MP0005076_abnormal_cell_differentiation2.28044240
20MP0001730_embryonic_growth_arrest2.26985941
21MP0003300_gastrointestinal_ulcer2.18427256
22MP0010030_abnormal_orbit_morphology2.03358374
23MP0008007_abnormal_cellular_replicative1.97995594
24MP0003890_abnormal_embryonic-extraembry1.95836513
25MP0003119_abnormal_digestive_system1.92879584
26MP0002084_abnormal_developmental_patter1.92274837
27MP0001672_abnormal_embryogenesis/_devel1.90552120
28MP0005380_embryogenesis_phenotype1.90552120
29MP0004947_skin_inflammation1.89106009
30MP0003123_paternal_imprinting1.88694318
31MP0002086_abnormal_extraembryonic_tissu1.85733272
32MP0004185_abnormal_adipocyte_glucose1.82658110
33MP0001697_abnormal_embryo_size1.81964165
34MP0010307_abnormal_tumor_latency1.81848009
35MP0002085_abnormal_embryonic_tissue1.81004583
36MP0008058_abnormal_DNA_repair1.79188493
37MP0005397_hematopoietic_system_phenotyp1.78721663
38MP0001545_abnormal_hematopoietic_system1.78721663
39MP0009278_abnormal_bone_marrow1.76639685
40MP0008877_abnormal_DNA_methylation1.76617393
41MP0002419_abnormal_innate_immunity1.74418093
42MP0005464_abnormal_platelet_physiology1.70757962
43MP0008932_abnormal_embryonic_tissue1.70131025
44MP0003786_premature_aging1.69503559
45MP0002822_catalepsy1.67167939
46MP0000490_abnormal_crypts_of1.65809896
47MP0004197_abnormal_fetal_growth/weight/1.65710716
48MP0003984_embryonic_growth_retardation1.65232193
49MP0004510_myositis1.64591629
50MP0002396_abnormal_hematopoietic_system1.62883786
51MP0002796_impaired_skin_barrier1.61352196
52MP0002080_prenatal_lethality1.60453649
53MP0002088_abnormal_embryonic_growth/wei1.60208183
54MP0005025_abnormal_response_to1.56125981
55MP0003091_abnormal_cell_migration1.55330518
56MP0000678_abnormal_parathyroid_gland1.53900207
57MP0003075_altered_response_to1.52993166
58MP0005000_abnormal_immune_tolerance1.52340136
59MP0000685_abnormal_immune_system1.47512035
60MP0008438_abnormal_cutaneous_collagen1.44207684
61MP0006292_abnormal_olfactory_placode1.41707326
62MP0002998_abnormal_bone_remodeling1.37191252
63MP0001533_abnormal_skeleton_physiology1.36670423
64MP0001835_abnormal_antigen_presentation1.36518145
65MP0002019_abnormal_tumor_incidence1.34480311
66MP0005409_darkened_coat_color1.33932975
67MP0003329_amyloid_beta_deposits1.33330255
68MP0000313_abnormal_cell_death1.31486551
69MP0002420_abnormal_adaptive_immunity1.27819758
70MP0004133_heterotaxia1.27621550
71MP0001819_abnormal_immune_cell1.27133190
72MP0004264_abnormal_extraembryonic_tissu1.25082519
73MP0001849_ear_inflammation1.24049966
74MP0002148_abnormal_hypersensitivity_rea1.23435930
75MP0002452_abnormal_antigen_presenting1.23119094
76MP0005499_abnormal_olfactory_system1.22535675
77MP0005394_taste/olfaction_phenotype1.22535675
78MP0005387_immune_system_phenotype1.20256614
79MP0001790_abnormal_immune_system1.20256614
80MP0002723_abnormal_immune_serum1.20203668
81MP0003283_abnormal_digestive_organ1.19945159
82MP0008770_decreased_survivor_rate1.19047905
83MP0008961_abnormal_basal_metabolism1.18379623
84MP0004808_abnormal_hematopoietic_stem1.17330036
85MP0001853_heart_inflammation1.14718527
86MP0002060_abnormal_skin_morphology1.14231434
87MP0000604_amyloidosis1.13335812
88MP0003828_pulmonary_edema1.11598146
89MP0009333_abnormal_splenocyte_physiolog1.09038660
90MP0002089_abnormal_postnatal_growth/wei1.09036866
91MP0005257_abnormal_intraocular_pressure1.08930183
92MP0003448_altered_tumor_morphology1.07797098
93MP0000703_abnormal_thymus_morphology1.07700630
94MP0002877_abnormal_melanocyte_morpholog1.06523106
95MP0001800_abnormal_humoral_immune1.06521020
96MP0003279_aneurysm1.06458945
97MP0000716_abnormal_immune_system1.06423848
98MP0010155_abnormal_intestine_physiology1.05918925
99MP0004858_abnormal_nervous_system1.05875311
100MP0003763_abnormal_thymus_physiology1.05018091
101MP0002429_abnormal_blood_cell1.03902687
102MP0002405_respiratory_system_inflammati1.02495612
103MP0005666_abnormal_adipose_tissue1.01759729
104MP0003566_abnormal_cell_adhesion0.99536470
105MP0001851_eye_inflammation0.99085435
106MP0006082_CNS_inflammation0.98847089
107MP0002249_abnormal_larynx_morphology0.98034745
108MP0009931_abnormal_skin_appearance0.96975676
109MP0005310_abnormal_salivary_gland0.95477034
110MP0005621_abnormal_cell_physiology0.95393887
111MP0002398_abnormal_bone_marrow0.94665125
112MP0002111_abnormal_tail_morphology0.93983193
113MP0001293_anophthalmia0.93780187
114MP0005023_abnormal_wound_healing0.92987861
115MP0001216_abnormal_epidermal_layer0.91981353
116MP0004233_abnormal_muscle_weight0.91768333
117MP0002254_reproductive_system_inflammat0.91613489
118MP0003567_abnormal_fetal_cardiomyocyte0.91474948
119MP0009785_altered_susceptibility_to0.90602099
120MP0005375_adipose_tissue_phenotype0.90249708
121MP0001873_stomach_inflammation0.88677814
122MP0005390_skeleton_phenotype0.88639444
123MP0000343_altered_response_to0.85852943
124MP0005166_decreased_susceptibility_to0.85763833
125MP0001845_abnormal_inflammatory_respons0.85370419
126MP0002722_abnormal_immune_system0.84231722
127MP0000689_abnormal_spleen_morphology0.84081756
128MP0005384_cellular_phenotype0.83399722
129MP0003861_abnormal_nervous_system0.83299359
130MP0002925_abnormal_cardiovascular_devel0.82852424
131MP0000767_abnormal_smooth_muscle0.80807547
132MP0001348_abnormal_lacrimal_gland0.79952960
133MP0004811_abnormal_neuron_physiology0.79810923
134MP0003935_abnormal_craniofacial_develop0.79795308
135MP0003121_genomic_imprinting0.78546642
136MP0002114_abnormal_axial_skeleton0.78103147
137MP0001145_abnormal_male_reproductive0.77960112
138MP0010234_abnormal_vibrissa_follicle0.77156557
139MP0000681_abnormal_thyroid_gland0.76819459
140MP0003453_abnormal_keratinocyte_physiol0.76524824
141MP0003755_abnormal_palate_morphology0.76226626
142MP0002210_abnormal_sex_determination0.75547234
143MP0002063_abnormal_learning/memory/cond0.75540749
144MP0000733_abnormal_muscle_development0.74970971
145MP0008469_abnormal_protein_level0.74481753
146MP0003183_abnormal_peptide_metabolism0.74085456
147MP0000358_abnormal_cell_content/0.73498372
148MP0003303_peritoneal_inflammation0.73466427
149MP0009703_decreased_birth_body0.73194666
150MP0003718_maternal_effect0.72730904
151MP0003656_abnormal_erythrocyte_physiolo0.69347945
152MP0000858_altered_metastatic_potential0.68697493
153MP0002269_muscular_atrophy0.67935193
154MP0009672_abnormal_birth_weight0.67355902
155MP0003635_abnormal_synaptic_transmissio0.67198103
156MP0000428_abnormal_craniofacial_morphol0.65635126
157MP0002116_abnormal_craniofacial_bone0.64578333
158MP0008995_early_reproductive_senescence0.64384719
159MP0000432_abnormal_head_morphology0.63055246
160MP0005623_abnormal_meninges_morphology0.62829735
161MP0002932_abnormal_joint_morphology0.62040796
162MP0008789_abnormal_olfactory_epithelium0.60916121
163MP0000653_abnormal_sex_gland0.60508889
164MP0001915_intracranial_hemorrhage0.58184185
165MP0005501_abnormal_skin_physiology0.58132213

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)3.86588007
2Annular pancreas (HP:0001734)3.76974575
3Abnormality of the lower motor neuron (HP:0002366)3.71779698
4Ependymoma (HP:0002888)3.44756698
5Basal cell carcinoma (HP:0002671)3.11047152
6Astrocytoma (HP:0009592)3.00422035
7Abnormality of the astrocytes (HP:0100707)3.00422035
8Eczematoid dermatitis (HP:0000976)2.95162637
9Patellar aplasia (HP:0006443)2.90765606
10Facial hemangioma (HP:0000329)2.86805207
11Selective tooth agenesis (HP:0001592)2.80385513
12Increased cerebral lipofuscin (HP:0011813)2.78852929
13Cellulitis (HP:0100658)2.78196934
14Abnormality of macrophages (HP:0004311)2.77788369
15Spinal muscular atrophy (HP:0007269)2.76962927
16Aplasia/Hypoplasia of the patella (HP:0006498)2.71647471
17Aplasia/hypoplasia of the humerus (HP:0006507)2.70651748
18Vertebral compression fractures (HP:0002953)2.66031383
19Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.64237813
20Short humerus (HP:0005792)2.63183538
21Recurrent abscess formation (HP:0002722)2.59876685
22Myokymia (HP:0002411)2.55711746
23Birth length less than 3rd percentile (HP:0003561)2.54783997
24Premature rupture of membranes (HP:0001788)2.54124895
25Recurrent bacterial skin infections (HP:0005406)2.53715720
26Intestinal fistula (HP:0100819)2.52515503
27Abnormality of liposaccharide metabolism (HP:0010968)2.51323203
28Abnormality of glycosphingolipid metabolism (HP:0004343)2.51323203
29Abnormality of glycolipid metabolism (HP:0010969)2.51323203
30Distal lower limb amyotrophy (HP:0008944)2.51308595
31Abnormality of the labia minora (HP:0012880)2.50896170
32Increased neuronal autofluorescent lipopigment (HP:0002074)2.47082554
33Protrusio acetabuli (HP:0003179)2.47036197
34Breast hypoplasia (HP:0003187)2.44290271
35Abnormality of the Achilles tendon (HP:0005109)2.42595317
36Polygenic inheritance (HP:0010982)2.39349947
37Tongue fasciculations (HP:0001308)2.37622394
38Rhabdomyosarcoma (HP:0002859)2.36685192
39Absent radius (HP:0003974)2.33857564
40Dysostosis multiplex (HP:0000943)2.32228816
41Rectal fistula (HP:0100590)2.30912980
42Rectovaginal fistula (HP:0000143)2.30912980
43Disproportionate tall stature (HP:0001519)2.30876875
44Broad face (HP:0000283)2.29801627
45Abnormality of the anterior horn cell (HP:0006802)2.29236552
46Degeneration of anterior horn cells (HP:0002398)2.29236552
47Genu recurvatum (HP:0002816)2.25663479
48Muscle fibrillation (HP:0010546)2.23700465
49Distal lower limb muscle weakness (HP:0009053)2.21782901
50Atrophy/Degeneration involving motor neurons (HP:0007373)2.21176701
51Multiple enchondromatosis (HP:0005701)2.20067324
52Glioma (HP:0009733)2.19212669
53Chronic obstructive pulmonary disease (HP:0006510)2.18783725
54Obstructive lung disease (HP:0006536)2.18783725
55Absent forearm bone (HP:0003953)2.18734042
56Aplasia involving forearm bones (HP:0009822)2.18734042
57Loss of speech (HP:0002371)2.15415739
58Missing ribs (HP:0000921)2.13928166
59Carpal bone hypoplasia (HP:0001498)2.13412122
60Increased connective tissue (HP:0009025)2.11124314
61Hyperacusis (HP:0010780)2.09484719
62Neoplasm of striated muscle (HP:0009728)2.09302788
63Distal upper limb amyotrophy (HP:0007149)2.09198516
64Upper limb amyotrophy (HP:0009129)2.09198516
65Fragile skin (HP:0001030)2.08361853
66Pointed chin (HP:0000307)2.08073936
67Abnormality of the aortic arch (HP:0012303)2.07492682
68Centrally nucleated skeletal muscle fibers (HP:0003687)2.07179660
69Neuronal loss in central nervous system (HP:0002529)2.06713613
70Axonal loss (HP:0003447)2.05644795
71Increased IgE level (HP:0003212)2.05148957
72Congenital hip dislocation (HP:0001374)2.05071688
73Acute lymphatic leukemia (HP:0006721)2.04924670
74Neoplasm of the oral cavity (HP:0100649)2.04416969
75Abnormality of the thoracic spine (HP:0100711)2.04103171
76Medulloblastoma (HP:0002885)2.03396125
77Thin bony cortex (HP:0002753)2.02994162
78Absent thumb (HP:0009777)2.02864905
79Premature ovarian failure (HP:0008209)2.02280721
80Vertebral fusion (HP:0002948)2.02060348
81Upper motor neuron abnormality (HP:0002127)2.01947043
82Abnormal gallbladder physiology (HP:0012438)2.01569840
83Cholecystitis (HP:0001082)2.01569840
84Short 5th finger (HP:0009237)2.00342820
85Ulnar bowing (HP:0003031)2.00181882
86Supranuclear gaze palsy (HP:0000605)1.99488839
87Shawl scrotum (HP:0000049)1.98356377
88Hypertensive crisis (HP:0100735)1.97711395
89Trismus (HP:0000211)1.96016510
90Ankyloglossia (HP:0010296)1.95271158
91Segmental peripheral demyelination/remyelination (HP:0003481)1.94584389
92Broad palm (HP:0001169)1.94072654
93Amyotrophic lateral sclerosis (HP:0007354)1.93464430
94Cerebral inclusion bodies (HP:0100314)1.92449372
95Slow saccadic eye movements (HP:0000514)1.91990325
96Abnormal number of incisors (HP:0011064)1.91775298
97Cafe-au-lait spot (HP:0000957)1.91695981
98Long palpebral fissure (HP:0000637)1.89636209
99Mediastinal lymphadenopathy (HP:0100721)1.89234807
100Pustule (HP:0200039)1.87234107
101Abnormal neuron morphology (HP:0012757)1.87041947
102Abnormality of the motor neurons (HP:0002450)1.87041947
103Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86485010
104Hyperparathyroidism (HP:0000843)1.85863597
105Renal duplication (HP:0000075)1.85238121
106Thoracic kyphosis (HP:0002942)1.84290295
107Gingivitis (HP:0000230)1.83742379
108Vaginal fistula (HP:0004320)1.82460752
109Achilles tendon contracture (HP:0001771)1.82304731
110Agnosia (HP:0010524)1.81964132
111Obstructive sleep apnea (HP:0002870)1.81152826
112Broad alveolar ridges (HP:0000187)1.81002495
113Abnormal number of erythroid precursors (HP:0012131)1.80847247
114Concave nail (HP:0001598)1.80484755
115Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.80395970
116Increased serum ferritin (HP:0003281)1.78464835
117Abnormality of the ileum (HP:0001549)1.77701860
118Orthostatic hypotension (HP:0001278)1.77533227
119Stridor (HP:0010307)1.77355029
120Poikiloderma (HP:0001029)1.76876939
121Broad thumb (HP:0011304)1.76571759
122Adenoma sebaceum (HP:0009720)1.76236348
123Angiofibromas (HP:0010615)1.76236348
124Hemorrhage of the eye (HP:0011885)1.76190278
125Gastrointestinal inflammation (HP:0004386)1.76151848
126Mitral regurgitation (HP:0001653)1.75957517
127Squamous cell carcinoma (HP:0002860)1.75874434
128Spinal cord lesions (HP:0100561)1.75755532
129Syringomyelia (HP:0003396)1.75755532
130Insomnia (HP:0100785)1.75569616
131Abnormality of polysaccharide metabolism (HP:0011012)1.75546225
132Abnormality of glycosaminoglycan metabolism (HP:0004371)1.75546225
133Abnormality of mucopolysaccharide metabolism (HP:0011020)1.75546225
134Fused cervical vertebrae (HP:0002949)1.75177223
135Cerebral aneurysm (HP:0004944)1.75075128
136Hand muscle atrophy (HP:0009130)1.74990632
137Papilledema (HP:0001085)1.74963432
138Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.74617729
139Short 1st metacarpal (HP:0010034)1.74617729
140Male infertility (HP:0003251)1.74476195
141Prominent nose (HP:0000448)1.74042531
142Preauricular skin tag (HP:0000384)1.73972234
143Neurofibrillary tangles (HP:0002185)1.73357105
144Lower limb amyotrophy (HP:0007210)1.72150356
145Vertebral hypoplasia (HP:0008417)1.72054864
146Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.72054864
147Impulsivity (HP:0100710)1.70501253
148Colon cancer (HP:0003003)1.70228291
149Blue sclerae (HP:0000592)1.70173317
150Mucopolysacchariduria (HP:0008155)1.70137681
151Urinary glycosaminoglycan excretion (HP:0003541)1.70137681
152Amyloidosis (HP:0011034)1.69732767
153Deep palmar crease (HP:0006191)1.69634812
154Skin tags (HP:0010609)1.69549224
155Abnormality of oral frenula (HP:0000190)1.69323741
156Chromosomal breakage induced by crosslinking agents (HP:0003221)1.69236135
157Atrophic scars (HP:0001075)1.69123625
158Petechiae (HP:0000967)1.68902400
159Purpura (HP:0000979)1.68676431
160Bone pain (HP:0002653)1.68491516
161Chromsome breakage (HP:0040012)1.67556181
162Abnormality of cells of the erythroid lineage (HP:0012130)1.67527462
163Deviation of the thumb (HP:0009603)1.67429525
164Dilatation of the ascending aorta (HP:0005111)1.66863496
165Microretrognathia (HP:0000308)1.66824444
166Interstitial pulmonary disease (HP:0006530)1.65964213
167Generalized amyotrophy (HP:0003700)1.65072943
168Myocardial infarction (HP:0001658)1.64739349
169Urticaria (HP:0001025)1.64486667
170Reticulocytosis (HP:0001923)1.64038962
171Flat acetabular roof (HP:0003180)1.63568067
172Increased variability in muscle fiber diameter (HP:0003557)1.63539698
173Difficulty climbing stairs (HP:0003551)1.63006327
174Polycythemia (HP:0001901)1.62764770
175Myositis (HP:0100614)1.62637439
176Nuclear cataract (HP:0100018)1.62297153
177Hepatosplenomegaly (HP:0001433)1.61800421
178Gastrointestinal dysmotility (HP:0002579)1.61370785
179Progressive muscle weakness (HP:0003323)1.60685341
180Cervical subluxation (HP:0003308)1.59940812
181Abnormality of the distal phalanges of the toes (HP:0010182)1.59903351
182Broad distal phalanx of finger (HP:0009836)1.59845804
183Pathologic fracture (HP:0002756)1.59759970
184Short nail (HP:0001799)1.58163645

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.64135937
2SMG13.43418647
3ERN13.17543020
4IRAK32.93404403
5LATS22.70135685
6CDC72.62403424
7TAOK12.56287646
8SIK12.52244105
9NME22.43574999
10EEF2K2.42764693
11MAP3K92.41909069
12ICK2.31196819
13TYRO32.18743167
14MAP3K112.17169929
15BUB12.16520582
16RIPK42.04240562
17MAP2K32.03697574
18EPHA42.00981569
19ALK1.95141421
20MAP3K101.90938524
21DDR21.83138243
22CDK71.82098456
23MAP3K61.81578546
24NEK11.81165018
25NEK21.72378594
26TRIB31.71668605
27DAPK11.65891279
28KSR21.65561749
29WEE11.52153087
30EPHA21.50426909
31IRAK41.49847272
32BMX1.46910422
33MAP3K131.46469783
34GRK61.44825569
35RAF11.40160444
36TESK11.40078874
37PRKD31.39535553
38MAP3K31.38366532
39STK101.29874186
40TTK1.29138208
41CHEK21.28203338
42PLK11.26938150
43MAP3K11.26364959
44PIM21.15764207
45SCYL21.13463490
46MATK1.13181556
47MAP3K81.12964202
48TTN1.12076435
49PIM11.11837939
50IRAK21.10407160
51RPS6KB21.07476240
52PKN21.07236867
53CHEK11.04294736
54EPHB11.03778983
55PRKD21.03447452
56CDK41.03343801
57TBK11.02906964
58PTK60.99691591
59TAOK20.99285250
60MAP4K10.98033704
61ZAP700.97490603
62MAP3K140.97402721
63TSSK60.97369352
64SRPK10.97108346
65TESK20.96286215
66BRAF0.96249682
67BRSK10.94271655
68SIK30.93274740
69PDPK10.92019366
70PDGFRA0.91637030
71PAK40.86549614
72AURKA0.86243225
73CDK20.85928026
74CDC42BPA0.85566287
75FGFR40.85392199
76MTOR0.83973128
77TYK20.83050353
78MST1R0.82342144
79EIF2AK10.81783114
80PTK20.81020629
81PAK60.80516592
82GRK50.79794886
83ATR0.79442974
84ARAF0.77622174
85RPS6KA20.76837814
86CDK60.75877372
87FGR0.74511961
88MOS0.72611557
89PRKG20.72178055
90STK380.69578101
91HIPK20.69216916
92PINK10.68897046
93SIK20.66953365
94JAK30.66411518
95ACVR1B0.65896395
96TNK20.65327834
97DYRK30.65103956
98MELK0.64957366
99NTRK30.64625538
100AURKB0.64420004
101RPS6KA40.62852892
102FES0.62838536
103MAP2K20.62351217
104KSR10.61942175
105UHMK10.61724522
106MAPKAPK30.61536284
107CDK11A0.61324802
108LRRK20.61014632
109CDK150.60614974
110PDK10.59757216
111BLK0.59248603
112MARK20.58754815
113RPS6KA10.58349769
114PRPF4B0.56785064
115CDK180.56611074
116LATS10.55983331
117CSF1R0.55401752
118MAPK110.54581777
119ATM0.53754613
120CAMKK10.53658339
121PAK10.51873594
122STK38L0.51805577
123PRKCI0.51381085
124AKT30.50118276
125LMTK20.49546041
126NTRK10.48818534
127CSK0.47988940
128RPS6KL10.47545804
129RPS6KC10.47545804
130HCK0.47510481
131BTK0.46973043
132MAPK120.46696158
133PLK30.46544068
134RIPK10.45706083
135CAMK1D0.45690193
136* CDK10.45402971
137DAPK20.44947730
138CDK140.44246140
139STK30.44051722
140RPS6KA60.43867614
141MAPK100.42698423
142CSNK1E0.42465268
143ABL20.42365296
144MAPKAPK20.41659435
145KDR0.38383526
146PAK20.35402271
147MAPK40.32699681

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.25755589
2DNA replication_Homo sapiens_hsa030303.20400124
3Mismatch repair_Homo sapiens_hsa034302.97840666
4RNA transport_Homo sapiens_hsa030132.68013506
5Other glycan degradation_Homo sapiens_hsa005112.61410973
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.53256110
7Base excision repair_Homo sapiens_hsa034102.33457002
8Spliceosome_Homo sapiens_hsa030402.23407340
9Cell cycle_Homo sapiens_hsa041102.11966826
10mRNA surveillance pathway_Homo sapiens_hsa030152.04479282
11Osteoclast differentiation_Homo sapiens_hsa043801.88168681
12mTOR signaling pathway_Homo sapiens_hsa041501.65388981
13Nucleotide excision repair_Homo sapiens_hsa034201.63326922
14Leishmaniasis_Homo sapiens_hsa051401.62403874
15p53 signaling pathway_Homo sapiens_hsa041151.61540868
16RNA polymerase_Homo sapiens_hsa030201.57306398
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.50500550
18Homologous recombination_Homo sapiens_hsa034401.49364576
19Oocyte meiosis_Homo sapiens_hsa041141.48741757
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47252761
21Thyroid cancer_Homo sapiens_hsa052161.47121945
22One carbon pool by folate_Homo sapiens_hsa006701.43282889
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.40577708
24Prion diseases_Homo sapiens_hsa050201.38288963
25Pentose phosphate pathway_Homo sapiens_hsa000301.34646184
26Fanconi anemia pathway_Homo sapiens_hsa034601.33583178
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33524771
28Bladder cancer_Homo sapiens_hsa052191.33280717
29Renal cell carcinoma_Homo sapiens_hsa052111.29357629
30Tuberculosis_Homo sapiens_hsa051521.25206918
31Chronic myeloid leukemia_Homo sapiens_hsa052201.24766483
32Lysosome_Homo sapiens_hsa041421.23192637
33RNA degradation_Homo sapiens_hsa030181.20000287
34Hippo signaling pathway_Homo sapiens_hsa043901.18348933
35Toxoplasmosis_Homo sapiens_hsa051451.17141157
36Colorectal cancer_Homo sapiens_hsa052101.16056406
37MicroRNAs in cancer_Homo sapiens_hsa052061.15962418
38VEGF signaling pathway_Homo sapiens_hsa043701.15406393
39Non-small cell lung cancer_Homo sapiens_hsa052231.14989585
40TNF signaling pathway_Homo sapiens_hsa046681.13840408
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10256142
42Influenza A_Homo sapiens_hsa051641.09342849
43Salmonella infection_Homo sapiens_hsa051321.08694541
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.06548985
45Hepatitis C_Homo sapiens_hsa051601.02525264
46Fructose and mannose metabolism_Homo sapiens_hsa000511.02364043
47Long-term potentiation_Homo sapiens_hsa047201.02089949
48Galactose metabolism_Homo sapiens_hsa000521.01771187
49Glioma_Homo sapiens_hsa052141.01551832
50Notch signaling pathway_Homo sapiens_hsa043301.00440166
51Acute myeloid leukemia_Homo sapiens_hsa052211.00381264
52Sphingolipid signaling pathway_Homo sapiens_hsa040711.00204366
53Olfactory transduction_Homo sapiens_hsa047400.97576407
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.97547726
55Ribosome_Homo sapiens_hsa030100.97149253
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97139015
57Amoebiasis_Homo sapiens_hsa051460.94847247
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94768815
59HTLV-I infection_Homo sapiens_hsa051660.94015515
60Malaria_Homo sapiens_hsa051440.93004147
61Shigellosis_Homo sapiens_hsa051310.92940305
62Viral carcinogenesis_Homo sapiens_hsa052030.92251294
63Endometrial cancer_Homo sapiens_hsa052130.91226497
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90872596
65Adherens junction_Homo sapiens_hsa045200.90551772
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90122603
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89452807
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.88934068
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87556842
70Pyrimidine metabolism_Homo sapiens_hsa002400.86664461
71Insulin signaling pathway_Homo sapiens_hsa049100.86492988
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.86124254
73Vitamin B6 metabolism_Homo sapiens_hsa007500.85548205
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85234017
75Small cell lung cancer_Homo sapiens_hsa052220.84918519
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84576358
77ErbB signaling pathway_Homo sapiens_hsa040120.84397860
78TGF-beta signaling pathway_Homo sapiens_hsa043500.84201438
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83491780
80Pancreatic cancer_Homo sapiens_hsa052120.83332352
81GnRH signaling pathway_Homo sapiens_hsa049120.81794549
82Measles_Homo sapiens_hsa051620.79821065
83Chemokine signaling pathway_Homo sapiens_hsa040620.79819914
84Gap junction_Homo sapiens_hsa045400.79600712
85Vibrio cholerae infection_Homo sapiens_hsa051100.78936332
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78852391
87Focal adhesion_Homo sapiens_hsa045100.78338939
88Epstein-Barr virus infection_Homo sapiens_hsa051690.78213186
89Wnt signaling pathway_Homo sapiens_hsa043100.76554488
90Basal transcription factors_Homo sapiens_hsa030220.76281634
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74930910
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74547895
93Viral myocarditis_Homo sapiens_hsa054160.74425306
94Inositol phosphate metabolism_Homo sapiens_hsa005620.73626693
95Estrogen signaling pathway_Homo sapiens_hsa049150.72089115
96Phagosome_Homo sapiens_hsa041450.71471417
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68883363
98Hepatitis B_Homo sapiens_hsa051610.68881164
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68410242
100Amphetamine addiction_Homo sapiens_hsa050310.68228140
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68058326
102Hedgehog signaling pathway_Homo sapiens_hsa043400.68020167
103MAPK signaling pathway_Homo sapiens_hsa040100.68006137
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67425813
105HIF-1 signaling pathway_Homo sapiens_hsa040660.67349045
106Apoptosis_Homo sapiens_hsa042100.66901024
107B cell receptor signaling pathway_Homo sapiens_hsa046620.66542654
108Pertussis_Homo sapiens_hsa051330.66392333
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63109751
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.63063180
111Prolactin signaling pathway_Homo sapiens_hsa049170.62207283
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61660122
113Choline metabolism in cancer_Homo sapiens_hsa052310.61404347
114Legionellosis_Homo sapiens_hsa051340.60897601
115Dorso-ventral axis formation_Homo sapiens_hsa043200.60739504
116T cell receptor signaling pathway_Homo sapiens_hsa046600.60439607
117Herpes simplex infection_Homo sapiens_hsa051680.58743221
118Staphylococcus aureus infection_Homo sapiens_hsa051500.58560221
119Platelet activation_Homo sapiens_hsa046110.58480972
120Proteoglycans in cancer_Homo sapiens_hsa052050.57054217
121Rap1 signaling pathway_Homo sapiens_hsa040150.55986180
122Biosynthesis of amino acids_Homo sapiens_hsa012300.55756933
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55669601
124Dopaminergic synapse_Homo sapiens_hsa047280.55068575
125Oxytocin signaling pathway_Homo sapiens_hsa049210.53151096
126Pathways in cancer_Homo sapiens_hsa052000.53126648
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53000593
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52987158
129Sulfur relay system_Homo sapiens_hsa041220.52852164
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52831583
131Synaptic vesicle cycle_Homo sapiens_hsa047210.51961266
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51667061
133Antigen processing and presentation_Homo sapiens_hsa046120.51261950
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50195043
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50170807
136AMPK signaling pathway_Homo sapiens_hsa041520.49588795
137Cyanoamino acid metabolism_Homo sapiens_hsa004600.49353037
138Basal cell carcinoma_Homo sapiens_hsa052170.49337759
139Insulin resistance_Homo sapiens_hsa049310.49169397
140Alcoholism_Homo sapiens_hsa050340.45924741
141Tight junction_Homo sapiens_hsa045300.45751246
142Prostate cancer_Homo sapiens_hsa052150.45671356
143Endocytosis_Homo sapiens_hsa041440.45603970
144Phospholipase D signaling pathway_Homo sapiens_hsa040720.44129242
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43061449
146Circadian rhythm_Homo sapiens_hsa047100.42759646
147Purine metabolism_Homo sapiens_hsa002300.42023541
148FoxO signaling pathway_Homo sapiens_hsa040680.41995102
149Melanogenesis_Homo sapiens_hsa049160.41969024

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »