KLF17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of attachment of spindle microtubules to kinetochore (GO:0051988)7.47818362
2mitotic metaphase plate congression (GO:0007080)7.26266327
3regulation of exit from mitosis (GO:0007096)5.84012927
4vitamin transmembrane transport (GO:0035461)5.81916756
5regulation of spindle organization (GO:0090224)5.67977311
6metaphase plate congression (GO:0051310)5.60018305
7piRNA metabolic process (GO:0034587)5.53783015
8regulation of meiosis (GO:0040020)5.48024438
9regulation of meiosis I (GO:0060631)5.33156627
10multicellular organism reproduction (GO:0032504)5.22214852
11oocyte maturation (GO:0001556)5.15839284
12maturation of 5.8S rRNA (GO:0000460)5.15358286
13negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.89324934
14monoubiquitinated protein deubiquitination (GO:0035520)4.87496166
15regulation of mitotic spindle organization (GO:0060236)4.86509582
16mitotic sister chromatid segregation (GO:0000070)4.76494828
17establishment of chromosome localization (GO:0051303)4.63579818
18meiotic cell cycle (GO:0051321)4.50048528
19positive regulation of chromosome segregation (GO:0051984)4.49522042
20female gamete generation (GO:0007292)4.43071254
21protein K6-linked ubiquitination (GO:0085020)4.42949212
22regulation of histone H3-K27 methylation (GO:0061085)4.42341406
23negative regulation of meiosis (GO:0045835)4.42064123
24attachment of spindle microtubules to kinetochore (GO:0008608)4.41999633
25regulation of meiotic cell cycle (GO:0051445)4.35877053
26histone H2A monoubiquitination (GO:0035518)4.29655308
27DNA replication checkpoint (GO:0000076)4.29322395
28regulation of chromosome segregation (GO:0051983)4.28675936
29mitotic chromosome condensation (GO:0007076)4.27094556
30DNA damage response, signal transduction resulting in transcription (GO:0042772)4.24640509
31purine nucleobase biosynthetic process (GO:0009113)4.18672232
32spindle checkpoint (GO:0031577)4.17423219
33regulation of RIG-I signaling pathway (GO:0039535)4.14692949
34male meiosis (GO:0007140)4.12475688
35regulation of female gonad development (GO:2000194)4.10022170
36negative regulation of hormone biosynthetic process (GO:0032353)4.06993924
37negative regulation of hormone metabolic process (GO:0032351)4.06993924
38regulation of acrosome reaction (GO:0060046)4.05038611
39protein localization to kinetochore (GO:0034501)4.03917789
40negative regulation of DNA-templated transcription, elongation (GO:0032785)4.01070141
41negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.01070141
42histone H2A ubiquitination (GO:0033522)3.97528621
43DNA damage induced protein phosphorylation (GO:0006975)3.90142463
44protein localization to chromosome, centromeric region (GO:0071459)3.88530395
45meiosis I (GO:0007127)3.87701049
46mitotic spindle checkpoint (GO:0071174)3.86045706
47regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.83527918
48regulation of sister chromatid cohesion (GO:0007063)3.82755562
49sister chromatid segregation (GO:0000819)3.79870015
50protein localization to chromosome (GO:0034502)3.78703991
51mitotic nuclear envelope disassembly (GO:0007077)3.75697757
52regulation of retinoic acid receptor signaling pathway (GO:0048385)3.74509195
53negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.70067193
54meiotic chromosome segregation (GO:0045132)3.69214298
55chromosome segregation (GO:0007059)3.64710059
56DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.64406669
57male meiosis I (GO:0007141)3.63465529
58rRNA modification (GO:0000154)3.62377251
59CENP-A containing nucleosome assembly (GO:0034080)3.56924909
60negative regulation of chromosome segregation (GO:0051985)3.56633160
61membrane disassembly (GO:0030397)3.54955503
62nuclear envelope disassembly (GO:0051081)3.54955503
63rRNA methylation (GO:0031167)3.52572421
64negative regulation of mitotic sister chromatid separation (GO:2000816)3.51426015
65negative regulation of mitotic sister chromatid segregation (GO:0033048)3.51426015
66negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.51426015
67negative regulation of sister chromatid segregation (GO:0033046)3.51426015
68nucleobase biosynthetic process (GO:0046112)3.50420346
69DNA replication-independent nucleosome assembly (GO:0006336)3.50052917
70DNA replication-independent nucleosome organization (GO:0034724)3.50052917
71folic acid metabolic process (GO:0046655)3.49846708
72ribosome assembly (GO:0042255)3.49013387
73S-adenosylmethionine metabolic process (GO:0046500)3.48607942
74regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.48433717
75inner cell mass cell proliferation (GO:0001833)3.47831168
76synaptonemal complex assembly (GO:0007130)3.45291460
77protein polyglutamylation (GO:0018095)3.43414623
78reproduction (GO:0000003)3.42972631
79mitotic spindle assembly checkpoint (GO:0007094)3.42867587
80regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.42513570
81ventricular cardiac muscle cell development (GO:0055015)3.42282743
82histone exchange (GO:0043486)3.41853102
83microtubule depolymerization (GO:0007019)3.40207791
84chromatin remodeling at centromere (GO:0031055)3.37532912
85spindle assembly checkpoint (GO:0071173)3.34646869
86regulation of mitotic metaphase/anaphase transition (GO:0030071)3.33624593
87DNA methylation involved in gamete generation (GO:0043046)3.30982305
88meiotic nuclear division (GO:0007126)3.30751725
89positive regulation of megakaryocyte differentiation (GO:0045654)3.28844693
90regulation of glucocorticoid metabolic process (GO:0031943)3.28475973
91positive regulation of protein homooligomerization (GO:0032464)3.24975594
92transcription from mitochondrial promoter (GO:0006390)3.22550309
93regulation of sister chromatid segregation (GO:0033045)3.21005162
94regulation of mitotic sister chromatid separation (GO:0010965)3.21005162
95regulation of mitotic sister chromatid segregation (GO:0033047)3.21005162
96snRNA transcription (GO:0009301)3.18722768
97behavioral response to nicotine (GO:0035095)3.18274367
98regulation of double-strand break repair via homologous recombination (GO:0010569)3.15722849
99meiotic cell cycle process (GO:1903046)3.14383032
100nuclear envelope organization (GO:0006998)3.13339053
101synaptonemal complex organization (GO:0070193)3.12601772
102negative regulation of meiotic cell cycle (GO:0051447)3.11361054
103negative regulation of nuclear division (GO:0051784)3.11213467
104regulation of DNA methylation (GO:0044030)3.10525568
105regulation of spindle checkpoint (GO:0090231)3.10293431
106sperm motility (GO:0030317)3.05895001
107microtubule severing (GO:0051013)3.05291076
1087-methylguanosine mRNA capping (GO:0006370)3.03216094
109positive regulation of prostaglandin secretion (GO:0032308)3.02617509
110glycine transport (GO:0015816)3.01807304
111positive regulation of uterine smooth muscle contraction (GO:0070474)2.98396402
112detection of light stimulus involved in visual perception (GO:0050908)2.98093804
113detection of light stimulus involved in sensory perception (GO:0050962)2.98093804
114sperm-egg recognition (GO:0035036)2.96147248
115retinal cone cell development (GO:0046549)2.94546556
116response to pheromone (GO:0019236)2.93360294
117termination of RNA polymerase III transcription (GO:0006386)2.91492942
118transcription elongation from RNA polymerase III promoter (GO:0006385)2.91492942
119L-fucose catabolic process (GO:0042355)2.91402708
120fucose catabolic process (GO:0019317)2.91402708
121L-fucose metabolic process (GO:0042354)2.91402708
122drinking behavior (GO:0042756)2.90740154
123regulation of female receptivity (GO:0045924)2.85960365
124aggressive behavior (GO:0002118)2.85212635
125regulation of cilium movement (GO:0003352)2.77845510
126DNA deamination (GO:0045006)2.71520914
127regulation of cytokine production involved in inflammatory response (GO:1900015)2.70393854
128mitochondrial RNA metabolic process (GO:0000959)2.65446256
129negative regulation of digestive system process (GO:0060457)2.65398295
130acrosome reaction (GO:0007340)2.65025019
131positive regulation of mitochondrial fission (GO:0090141)2.63622176
132G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.58119446
133single fertilization (GO:0007338)2.55306083
134somite rostral/caudal axis specification (GO:0032525)2.52176181
135chaperone-mediated protein transport (GO:0072321)2.51423948
136negative regulation of mast cell activation (GO:0033004)2.50012937
137protein K11-linked deubiquitination (GO:0035871)2.48604544
138positive regulation of cAMP-mediated signaling (GO:0043950)2.48317433
139sleep (GO:0030431)2.48223564
140calcium ion-dependent exocytosis (GO:0017156)2.47875662
141regulation of action potential (GO:0098900)2.45317922
142axoneme assembly (GO:0035082)2.45040463
143binding of sperm to zona pellucida (GO:0007339)2.43745523
144positive regulation of catecholamine secretion (GO:0033605)2.43476941
145detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.43346627
146water-soluble vitamin biosynthetic process (GO:0042364)2.43225513
147regulation of uterine smooth muscle contraction (GO:0070472)2.40617840
148female mating behavior (GO:0060180)2.40043791
149detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.39556662
150keratinocyte development (GO:0003334)2.38419270
151positive regulation of digestive system process (GO:0060456)2.37159865
152positive regulation of action potential (GO:0045760)2.35042128
153positive regulation of fatty acid transport (GO:2000193)2.34444506
154negative regulation of transcription regulatory region DNA binding (GO:2000678)2.33785124
155regulation of nuclear cell cycle DNA replication (GO:0033262)2.33275657
156epithelial cilium movement (GO:0003351)2.32787565
157cell-cell recognition (GO:0009988)2.32261783
158positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.32043007
159cellular response to pH (GO:0071467)2.31209303
160fusion of sperm to egg plasma membrane (GO:0007342)2.30681962
161cellular biogenic amine biosynthetic process (GO:0042401)2.29474937
162seminiferous tubule development (GO:0072520)2.28825939
163transcription from RNA polymerase III promoter (GO:0006383)2.28754038
164regulation of prostaglandin secretion (GO:0032306)2.28110162
165glycerophospholipid catabolic process (GO:0046475)2.27989678
166regulation of microtubule-based movement (GO:0060632)2.26310594
167fertilization (GO:0009566)2.25093352
168cellular ketone body metabolic process (GO:0046950)2.24944742
169response to acidic pH (GO:0010447)2.24438278
170autophagic vacuole fusion (GO:0000046)2.24255383
171cAMP catabolic process (GO:0006198)2.23948645
172regulation of glucokinase activity (GO:0033131)2.23692735
173regulation of hexokinase activity (GO:1903299)2.23692735
174negative regulation of reproductive process (GO:2000242)2.22793914
175DNA integration (GO:0015074)2.21885811
176ketone body metabolic process (GO:1902224)2.21317977
177regulation of penile erection (GO:0060405)2.21302656
178nonmotile primary cilium assembly (GO:0035058)2.21233232
179tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.20737602
180RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.20737602
181autophagic vacuole assembly (GO:0000045)2.19937013

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.77117733
2E2F7_22180533_ChIP-Seq_HELA_Human5.67739829
3EZH2_22144423_ChIP-Seq_EOC_Human4.84212716
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.75576312
5ZNF274_21170338_ChIP-Seq_K562_Hela4.55315919
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.28898033
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.25964101
8KAP1_22055183_ChIP-Seq_ESCs_Mouse4.04279094
9AR_21909140_ChIP-Seq_LNCAP_Human3.98370708
10NOTCH1_21737748_ChIP-Seq_TLL_Human3.84071949
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.51939087
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.02953614
13E2F4_17652178_ChIP-ChIP_JURKAT_Human3.01473829
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.67682523
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.55350473
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.54620041
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.43327376
18GBX2_23144817_ChIP-Seq_PC3_Human2.42134920
19VDR_22108803_ChIP-Seq_LS180_Human2.34561340
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.33228845
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28291422
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27145365
23GATA1_26923725_Chip-Seq_HPCs_Mouse2.15841139
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.12132155
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.10811477
26NANOG_18555785_ChIP-Seq_MESCs_Mouse2.09364031
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.95376817
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94763728
29* ETV1_20927104_ChIP-Seq_GIST48_Human1.93718626
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90725412
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.86261980
32* TBL1_22424771_ChIP-Seq_293T_Human1.82853247
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.79137910
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.78911694
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.77242289
36* PHF8_20622853_ChIP-Seq_HELA_Human1.76699196
37* RBPJ_21746931_ChIP-Seq_IB4_Human1.75976909
38TP53_22573176_ChIP-Seq_HFKS_Human1.73222411
39* NFYB_21822215_ChIP-Seq_K562_Human1.71858384
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62130548
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61851011
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.61525926
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.61525926
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.61525926
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.61299651
46GABP_19822575_ChIP-Seq_HepG2_Human1.61110694
47LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59764117
48* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.57227909
49KLF4_18555785_ChIP-Seq_MESCs_Mouse1.56768298
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.52442294
51IGF1R_20145208_ChIP-Seq_DFB_Human1.51515696
52IRF1_19129219_ChIP-ChIP_H3396_Human1.50783800
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50621019
54* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.50399529
55* GATA6_21074721_ChIP-Seq_CACO-2_Human1.49378501
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.47954722
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46564872
58RUNX1_26923725_Chip-Seq_HPCs_Mouse1.44246620
59P300_19829295_ChIP-Seq_ESCs_Human1.43972666
60MYC_19030024_ChIP-ChIP_MESCs_Mouse1.42387667
61* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.42052265
62NANOG_20526341_ChIP-Seq_ESCs_Human1.42019274
63* HNFA_21074721_ChIP-Seq_CACO-2_Human1.41643581
64ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39990045
65KDM5A_27292631_Chip-Seq_BREAST_Human1.38146462
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38006885
67REST_21632747_ChIP-Seq_MESCs_Mouse1.36713974
68KAP1_27257070_Chip-Seq_ESCs_Mouse1.36120285
69* NFYA_21822215_ChIP-Seq_K562_Human1.35860314
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35630574
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.35461022
72HOXB7_26014856_ChIP-Seq_BT474_Human1.33971600
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33194821
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.31623316
75CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.30341323
76NANOG_19829295_ChIP-Seq_ESCs_Human1.29959133
77SOX2_19829295_ChIP-Seq_ESCs_Human1.29959133
78VDR_23849224_ChIP-Seq_CD4+_Human1.29772045
79NCOR_22424771_ChIP-Seq_293T_Human1.28691761
80MYC_18940864_ChIP-ChIP_HL60_Human1.26465596
81MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25643145
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23544949
83BCAT_22108803_ChIP-Seq_LS180_Human1.23356105
84ER_23166858_ChIP-Seq_MCF-7_Human1.23114351
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23113865
86SMAD4_21799915_ChIP-Seq_A2780_Human1.22809184
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21165182
88EWS_26573619_Chip-Seq_HEK293_Human1.19927823
89TAF15_26573619_Chip-Seq_HEK293_Human1.18300336
90SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18241323
91CBP_20019798_ChIP-Seq_JUKART_Human1.18020310
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18020310
93POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17889696
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17670919
95RAC3_21632823_ChIP-Seq_H3396_Human1.17437123
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16884142
97ERA_21632823_ChIP-Seq_H3396_Human1.16676445
98AR_25329375_ChIP-Seq_VCAP_Human1.15021994
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15007597
100CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14529695
101STAT3_23295773_ChIP-Seq_U87_Human1.14462532
102BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14421929
103E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13858437
104NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13618100
105* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.13560047
106SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12647933
107P53_21459846_ChIP-Seq_SAOS-2_Human1.11668669
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11442365
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11442365
110PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10603821
111FUS_26573619_Chip-Seq_HEK293_Human1.09701432
112MYC_19829295_ChIP-Seq_ESCs_Human1.07874963
113NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.06950380
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06861074
115* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06657032
116HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06529512
117TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.06405972
118* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06129910
119CBX2_27304074_Chip-Seq_ESCs_Mouse1.05982829
120PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04861768
121AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04747564
122E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04472588
123TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04247353
124* TCF4_23295773_ChIP-Seq_U87_Human1.02832711
125* RUNX2_22187159_ChIP-Seq_PCA_Human1.02122779
126ZNF263_19887448_ChIP-Seq_K562_Human1.01970391
127EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01790970
128FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01210189
129OCT4_20526341_ChIP-Seq_ESCs_Human1.00793441
130XRN2_22483619_ChIP-Seq_HELA_Human0.99174203
131* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.98749677
132FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98389472
133AR_20517297_ChIP-Seq_VCAP_Human0.98181415
134PRDM14_20953172_ChIP-Seq_ESCs_Human0.96628293
135NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95861550
136STAT1_17558387_ChIP-Seq_HELA_Human0.95782274
137POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94420899
138TCF4_22108803_ChIP-Seq_LS180_Human0.93550387
139SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93376751
140DCP1A_22483619_ChIP-Seq_HELA_Human0.92401339
141TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91814335
142PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91745648
143CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91237582
144* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88283885
145* GATA3_21867929_ChIP-Seq_TH1_Mouse0.87379249
146POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87173267
147CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86289341
148ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85946714
149FOXP3_21729870_ChIP-Seq_TREG_Human0.83569173
150TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83179290
151TBX5_21415370_ChIP-Seq_HL-1_Mouse0.82679808
152ZFX_18555785_ChIP-Seq_MESCs_Mouse0.82492997
153KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.82178005
154TCF3_18692474_ChIP-Seq_MESCs_Mouse0.81884516
155SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.81084867
156MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80756245
157GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80007267
158CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79416422
159NANOG_18692474_ChIP-Seq_MESCs_Mouse0.76013205
160FOXH1_21741376_ChIP-Seq_EPCs_Human0.75586249
161POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.74710189
162SRF_21415370_ChIP-Seq_HL-1_Mouse0.73331521
163RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.73057474
164YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.72715130
165NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.71787643
166TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.71334258
167SPI1_26923725_Chip-Seq_HPCs_Mouse0.70898545
168ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.70724268
169FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.70609280
170RNF2_27304074_Chip-Seq_NSC_Mouse0.69910573
171STAT6_21828071_ChIP-Seq_BEAS2B_Human0.69826801
172CDX2_22108803_ChIP-Seq_LS180_Human0.69126223
173TTF2_22483619_ChIP-Seq_HELA_Human0.68812603
174NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.67490294
175SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.66515292
176ATF3_27146783_Chip-Seq_COLON_Human0.65726237

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect6.00065346
2MP0003693_abnormal_embryo_hatching5.44731196
3MP0005451_abnormal_body_composition5.27582915
4MP0002102_abnormal_ear_morphology4.69850459
5MP0003646_muscle_fatigue4.21437234
6MP0001986_abnormal_taste_sensitivity4.05121106
7MP0003111_abnormal_nucleus_morphology4.00459476
8MP0010094_abnormal_chromosome_stability3.62989524
9MP0005423_abnormal_somatic_nervous3.31971725
10MP0008877_abnormal_DNA_methylation3.27571994
11MP0003123_paternal_imprinting3.23874303
12MP0003077_abnormal_cell_cycle3.22093369
13MP0004957_abnormal_blastocyst_morpholog3.09683852
14MP0005410_abnormal_fertilization2.89113661
15MP0002653_abnormal_ependyma_morphology2.62981124
16MP0005395_other_phenotype2.51692747
17MP0001968_abnormal_touch/_nociception2.47378471
18MP0008260_abnormal_autophagy2.41229985
19MP0002138_abnormal_hepatobiliary_system2.28954543
20MP0003136_yellow_coat_color2.28458895
21MP0003699_abnormal_female_reproductive2.20399219
22MP0005551_abnormal_eye_electrophysiolog2.20007722
23MP0001119_abnormal_female_reproductive2.17245074
24MP0001929_abnormal_gametogenesis2.16750217
25MP0006276_abnormal_autonomic_nervous2.13805752
26MP0003880_abnormal_central_pattern2.12140965
27MP0006292_abnormal_olfactory_placode2.05142259
28MP0002736_abnormal_nociception_after2.05023553
29MP0002210_abnormal_sex_determination2.04188667
30MP0003195_calcinosis2.03716504
31MP0000653_abnormal_sex_gland2.02286061
32MP0009840_abnormal_foam_cell1.92767789
33MP0008932_abnormal_embryonic_tissue1.88668064
34MP0004142_abnormal_muscle_tone1.82178295
35MP0000372_irregular_coat_pigmentation1.80838632
36MP0001730_embryonic_growth_arrest1.78811535
37MP0005408_hypopigmentation1.76137585
38MP0002277_abnormal_respiratory_mucosa1.65533126
39MP0008007_abnormal_cellular_replicative1.65377549
40MP0004147_increased_porphyrin_level1.63445291
41MP0003937_abnormal_limbs/digits/tail_de1.61849873
42MP0001145_abnormal_male_reproductive1.59647057
43MP0005394_taste/olfaction_phenotype1.59646363
44MP0005499_abnormal_olfactory_system1.59646363
45MP0004885_abnormal_endolymph1.57170852
46MP0000350_abnormal_cell_proliferation1.56687589
47MP0008058_abnormal_DNA_repair1.56335419
48MP0000462_abnormal_digestive_system1.50844639
49MP0001672_abnormal_embryogenesis/_devel1.45507021
50MP0005380_embryogenesis_phenotype1.45507021
51MP0002249_abnormal_larynx_morphology1.45187581
52MP0005379_endocrine/exocrine_gland_phen1.43073556
53MP0009745_abnormal_behavioral_response1.42147723
54MP0002161_abnormal_fertility/fecundity1.39490103
55MP0001697_abnormal_embryo_size1.39157006
56MP0002085_abnormal_embryonic_tissue1.35448455
57MP0008057_abnormal_DNA_replication1.35287740
58MP0003786_premature_aging1.35074304
59MP0000579_abnormal_nail_morphology1.34572669
60MP0003121_genomic_imprinting1.34143961
61MP0002272_abnormal_nervous_system1.32927561
62MP0008789_abnormal_olfactory_epithelium1.30435120
63MP0008872_abnormal_physiological_respon1.29263285
64MP0010307_abnormal_tumor_latency1.27035068
65MP0005174_abnormal_tail_pigmentation1.25113030
66MP0009379_abnormal_foot_pigmentation1.23911205
67MP0000631_abnormal_neuroendocrine_gland1.23809297
68MP0005310_abnormal_salivary_gland1.22535506
69MP0003252_abnormal_bile_duct1.21713565
70MP0001529_abnormal_vocalization1.20823959
71MP0003315_abnormal_perineum_morphology1.18984678
72MP0000569_abnormal_digit_pigmentation1.18687626
73MP0005253_abnormal_eye_physiology1.17799381
74MP0002837_dystrophic_cardiac_calcinosis1.17151579
75MP0001485_abnormal_pinna_reflex1.17148946
76MP0003656_abnormal_erythrocyte_physiolo1.16597109
77MP0008875_abnormal_xenobiotic_pharmacok1.15700528
78MP0002557_abnormal_social/conspecific_i1.14648433
79MP0000015_abnormal_ear_pigmentation1.13325640
80MP0004742_abnormal_vestibular_system1.12811141
81MP0002084_abnormal_developmental_patter1.12498838
82MP0003984_embryonic_growth_retardation1.12123840
83MP0002234_abnormal_pharynx_morphology1.11910446
84MP0006072_abnormal_retinal_apoptosis1.11493435
85MP0001486_abnormal_startle_reflex1.11210912
86MP0003938_abnormal_ear_development1.10672462
87MP0004185_abnormal_adipocyte_glucose1.08058163
88MP0005645_abnormal_hypothalamus_physiol1.07748699
89MP0002088_abnormal_embryonic_growth/wei1.07486460
90MP0003698_abnormal_male_reproductive1.06806928
91MP0003221_abnormal_cardiomyocyte_apopto1.06628612
92MP0002876_abnormal_thyroid_physiology1.05682567
93MP0002735_abnormal_chemical_nociception1.03938434
94MP0005085_abnormal_gallbladder_physiolo1.03445274
95MP0005377_hearing/vestibular/ear_phenot1.02378118
96MP0003878_abnormal_ear_physiology1.02378118
97MP0002080_prenatal_lethality1.01981333
98MP0002572_abnormal_emotion/affect_behav1.00213917
99MP0001501_abnormal_sleep_pattern0.99193332
100MP0001984_abnormal_olfaction0.98396373
101MP0002163_abnormal_gland_morphology0.94140294
102MP0005075_abnormal_melanosome_morpholog0.94092712
103MP0003119_abnormal_digestive_system0.91865384
104MP0009046_muscle_twitch0.91586074
105MP0001919_abnormal_reproductive_system0.89897371
106MP0002928_abnormal_bile_duct0.89293967
107MP0004133_heterotaxia0.89069079
108MP0005084_abnormal_gallbladder_morpholo0.88273760
109MP0003890_abnormal_embryonic-extraembry0.86880875
110MP0002638_abnormal_pupillary_reflex0.85659313
111MP0002086_abnormal_extraembryonic_tissu0.84189864
112MP0005083_abnormal_biliary_tract0.83524395
113MP0002095_abnormal_skin_pigmentation0.83275274
114MP0001905_abnormal_dopamine_level0.82069345
115MP0003186_abnormal_redox_activity0.81069276
116MP0005621_abnormal_cell_physiology0.80809848
117MP0001963_abnormal_hearing_physiology0.80381762
118MP0001502_abnormal_circadian_rhythm0.80047302
119MP0002734_abnormal_mechanical_nocicepti0.79707862
120MP0000026_abnormal_inner_ear0.78698329
121MP0002019_abnormal_tumor_incidence0.78587697
122MP0005365_abnormal_bile_salt0.78172303
123MP0002067_abnormal_sensory_capabilities0.77527529
124MP0003635_abnormal_synaptic_transmissio0.76707485
125MP0005257_abnormal_intraocular_pressure0.76300918
126MP0009333_abnormal_splenocyte_physiolog0.76271857
127MP0000049_abnormal_middle_ear0.74870075
128MP0001764_abnormal_homeostasis0.74507716
129MP0005195_abnormal_posterior_eye0.73281405
130MP0002229_neurodegeneration0.72978185
131MP0000427_abnormal_hair_cycle0.72710212
132MP0002184_abnormal_innervation0.72643397
133MP0004264_abnormal_extraembryonic_tissu0.71128105
134MP0003787_abnormal_imprinting0.68995664
135MP0000490_abnormal_crypts_of0.67015023
136MP0005187_abnormal_penis_morphology0.65119004
137MP0008995_early_reproductive_senescence0.65016643
138MP0000639_abnormal_adrenal_gland0.64941010
139MP0005389_reproductive_system_phenotype0.64550007
140MP0004145_abnormal_muscle_electrophysio0.64180243
141MP0003755_abnormal_palate_morphology0.64096665
142MP0005646_abnormal_pituitary_gland0.62521486
143MP0001915_intracranial_hemorrhage0.62451871
144MP0005384_cellular_phenotype0.62397194
145MP0001346_abnormal_lacrimal_gland0.62258987
146MP0000313_abnormal_cell_death0.62120276
147MP0009672_abnormal_birth_weight0.60407259
148MP0003879_abnormal_hair_cell0.58751737
149MP0002127_abnormal_cardiovascular_syste0.57544690
150MP0003935_abnormal_craniofacial_develop0.56466251
151MP0010368_abnormal_lymphatic_system0.54442958
152MP0006138_congestive_heart_failure0.53878156
153MP0002177_abnormal_outer_ear0.53295629
154MP0003329_amyloid_beta_deposits0.53214864
155MP0005397_hematopoietic_system_phenotyp0.52579688
156MP0001545_abnormal_hematopoietic_system0.52579688
157MP0000750_abnormal_muscle_regeneration0.52182432
158MP0010234_abnormal_vibrissa_follicle0.52125730
159MP0000383_abnormal_hair_follicle0.51050463
160MP0002160_abnormal_reproductive_system0.51009389
161MP0010678_abnormal_skin_adnexa0.50999839
162MP0005647_abnormal_sex_gland0.50744319
163MP0000432_abnormal_head_morphology0.50298170
164MP0004510_myositis0.49324687
165MP0001849_ear_inflammation0.49099226
166MP0002396_abnormal_hematopoietic_system0.47999467
167MP0005508_abnormal_skeleton_morphology0.47729461
168MP0001851_eye_inflammation0.46149325
169MP0010030_abnormal_orbit_morphology0.43579503
170MP0009384_cardiac_valve_regurgitation0.43535330

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)6.79598426
2Breast hypoplasia (HP:0003187)5.75713096
3Birth length less than 3rd percentile (HP:0003561)5.61748489
4Patellar aplasia (HP:0006443)4.58901328
5Flat capital femoral epiphysis (HP:0003370)4.52288073
6Aplasia/Hypoplasia of the patella (HP:0006498)4.39895403
7Congenital stationary night blindness (HP:0007642)4.25736440
8Facial hemangioma (HP:0000329)4.25372443
9Carpal bone hypoplasia (HP:0001498)4.15385884
10Abnormal rod and cone electroretinograms (HP:0008323)4.02650492
11Secondary amenorrhea (HP:0000869)3.94668373
12Abnormality of the labia minora (HP:0012880)3.91460217
13Gout (HP:0001997)3.86880958
14Attenuation of retinal blood vessels (HP:0007843)3.82577067
15Premature ovarian failure (HP:0008209)3.78917322
16Shawl scrotum (HP:0000049)3.76049484
17Adrenal hypoplasia (HP:0000835)3.73513163
18Capillary hemangiomas (HP:0005306)3.68207757
19Severe visual impairment (HP:0001141)3.65356506
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.58339537
21Chromsome breakage (HP:0040012)3.58096690
22Impulsivity (HP:0100710)3.53672982
23Abnormality of the fovea (HP:0000493)3.42799814
24Abnormality of midbrain morphology (HP:0002418)3.37524352
25Molar tooth sign on MRI (HP:0002419)3.37524352
26Breast aplasia (HP:0100783)3.34516473
27Oligodactyly (hands) (HP:0001180)3.32184980
28Aplasia/Hypoplasia of the breasts (HP:0010311)3.29042505
29Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.27102127
30Pancreatic fibrosis (HP:0100732)3.24789082
31Type II lissencephaly (HP:0007260)3.09501442
32Absent rod-and cone-mediated responses on ERG (HP:0007688)3.08138695
33Pendular nystagmus (HP:0012043)3.05807929
34Bony spicule pigmentary retinopathy (HP:0007737)3.01870805
35Cerebral hypomyelination (HP:0006808)3.00986607
36Infertility (HP:0000789)3.00545344
37Sparse lateral eyebrow (HP:0005338)2.99145052
38True hermaphroditism (HP:0010459)2.92148069
39Atrioventricular block (HP:0001678)2.89870346
40Decreased central vision (HP:0007663)2.89667332
41Oligodactyly (HP:0012165)2.88826746
42Irregular epiphyses (HP:0010582)2.87090999
43Abnormality of the proximal phalanges of the hand (HP:0009834)2.86453736
44Hypoplasia of the capital femoral epiphysis (HP:0003090)2.84224502
45Aplasia/hypoplasia of the uterus (HP:0008684)2.82681842
46Papillary thyroid carcinoma (HP:0002895)2.82608453
47Hyperglycinemia (HP:0002154)2.79366728
48Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.72456145
49Aplasia/Hypoplasia involving the musculature (HP:0001460)2.69128686
50Abnormality of macular pigmentation (HP:0008002)2.68892076
51Aplasia/Hypoplasia of the macula (HP:0008059)2.67432943
52Abnormality of the preputium (HP:0100587)2.63984237
53Absent radius (HP:0003974)2.63315493
54Abnormality of lateral ventricle (HP:0030047)2.60489314
55Nephronophthisis (HP:0000090)2.57668763
56Hypoplasia of the uterus (HP:0000013)2.57079904
57Abnormal drinking behavior (HP:0030082)2.56488488
58Polydipsia (HP:0001959)2.56488488
59Entropion (HP:0000621)2.55762522
60Hypophosphatemic rickets (HP:0004912)2.54768208
61Medial flaring of the eyebrow (HP:0010747)2.52226552
62Aplasia involving forearm bones (HP:0009822)2.50163317
63Absent forearm bone (HP:0003953)2.50163317
64Abnormality of chromosome stability (HP:0003220)2.49688233
65Rough bone trabeculation (HP:0100670)2.49066175
66Mutism (HP:0002300)2.45847261
67Aplasia/Hypoplasia affecting the retina (HP:0008061)2.45732311
68Abnormal spermatogenesis (HP:0008669)2.45719847
69Meckel diverticulum (HP:0002245)2.43640887
70Oral leukoplakia (HP:0002745)2.41916800
71Insulin-resistant diabetes mellitus (HP:0000831)2.40195099
72Aplasia/Hypoplasia of the tibia (HP:0005772)2.39625431
73Aplasia/Hypoplasia of the uvula (HP:0010293)2.38365895
74Constricted visual fields (HP:0001133)2.37215566
75Abnormal pancreas size (HP:0012094)2.37031098
76Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.36672304
77Type 2 muscle fiber atrophy (HP:0003554)2.35739037
78Muscle fiber atrophy (HP:0100295)2.29363444
79Tetraplegia (HP:0002445)2.29236779
80CNS hypomyelination (HP:0003429)2.28837486
81Pulmonary fibrosis (HP:0002206)2.28226052
82Anterior segment dysgenesis (HP:0007700)2.27059855
83Bundle branch block (HP:0011710)2.26267266
84Dynein arm defect of respiratory motile cilia (HP:0012255)2.24654971
85Absent/shortened dynein arms (HP:0200106)2.24654971
86Abnormality of the ileum (HP:0001549)2.22210323
87Pustule (HP:0200039)2.21931939
88Segmental peripheral demyelination/remyelination (HP:0003481)2.21702262
89Concave nail (HP:0001598)2.20916671
90Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.20213836
91Abnormality of the epiphysis of the femoral head (HP:0010574)2.19932034
92Abnormality of the renal medulla (HP:0100957)2.19788058
93Acute myeloid leukemia (HP:0004808)2.19762725
94Gaze-evoked nystagmus (HP:0000640)2.18578582
95Supernumerary spleens (HP:0009799)2.18482348
96Short tibia (HP:0005736)2.17925999
97Progressive cerebellar ataxia (HP:0002073)2.17475156
98Abnormality of chromosome segregation (HP:0002916)2.17426727
99Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.16423719
100Absent epiphyses (HP:0010577)2.16423719
101Cerebellar dysplasia (HP:0007033)2.16172345
102Sclerocornea (HP:0000647)2.14866433
103Polyuria (HP:0000103)2.13391186
104Abnormality of alanine metabolism (HP:0010916)2.13142162
105Hyperalaninemia (HP:0003348)2.13142162
106Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13142162
107Aplasia/Hypoplasia of the tongue (HP:0010295)2.13131636
108Rhinitis (HP:0012384)2.12575323
109Optic nerve hypoplasia (HP:0000609)2.11261703
110Small intestinal stenosis (HP:0012848)2.10151245
111Duodenal stenosis (HP:0100867)2.10151245
112Absent thumb (HP:0009777)2.08617116
113Limb dystonia (HP:0002451)2.07404164
114Acute necrotizing encephalopathy (HP:0006965)2.07235775
115Absent hand (HP:0004050)2.07221093
116Wrist flexion contracture (HP:0001239)2.06548432
117Retinal dysplasia (HP:0007973)2.06531953
118Hypergonadotropic hypogonadism (HP:0000815)2.06084488
119Decreased circulating renin level (HP:0003351)2.06010899
120Overlapping toe (HP:0001845)2.05908873
121Hyperglycinuria (HP:0003108)2.03725071
122Heart block (HP:0012722)2.03547912
123Abnormality of abdominal situs (HP:0011620)2.03074923
124Abdominal situs inversus (HP:0003363)2.03074923
125Muscle fiber splitting (HP:0003555)2.02297321
126Abnormality of the femoral head (HP:0003368)2.02209268
127Abnormality of the fingertips (HP:0001211)2.02153799
128Hyperglycemia (HP:0003074)2.02056147
129Abolished electroretinogram (ERG) (HP:0000550)2.01719306
130Cystic hygroma (HP:0000476)2.01552968
131Azoospermia (HP:0000027)2.01346938
132Congenital malformation of the right heart (HP:0011723)2.01114059
133Double outlet right ventricle (HP:0001719)2.01114059
134Optic disc pallor (HP:0000543)2.00851987
135Short nail (HP:0001799)1.99990700
136Progressive inability to walk (HP:0002505)1.99789034
137Male pseudohermaphroditism (HP:0000037)1.99091066
138Areflexia of lower limbs (HP:0002522)1.98891270
139Prostate neoplasm (HP:0100787)1.98504990
140Generalized aminoaciduria (HP:0002909)1.98138811
141Cystic liver disease (HP:0006706)1.97772887
142Abnormal ciliary motility (HP:0012262)1.97719515
143Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.97410818
144Abnormality of femoral epiphyses (HP:0006499)1.97410818
145Abnormality of the renal cortex (HP:0011035)1.97100744
146Tubular atrophy (HP:0000092)1.97059227
147Increased purine levels (HP:0004368)1.96466754
148Hyperuricemia (HP:0002149)1.96466754
149Inability to walk (HP:0002540)1.96436448
150Abnormal trabecular bone morphology (HP:0100671)1.95383161
151Pancreatic cysts (HP:0001737)1.94968451
152Chronic bronchitis (HP:0004469)1.94833245
153Abnormal respiratory motile cilium morphology (HP:0005938)1.94716826
154Abnormal respiratory epithelium morphology (HP:0012253)1.94716826
155Small epiphyses (HP:0010585)1.94691808
156Scotoma (HP:0000575)1.93437537
157Short thumb (HP:0009778)1.93392559
158Ventricular fibrillation (HP:0001663)1.92261203
159Abnormality of urine glucose concentration (HP:0011016)1.91054671
160Glycosuria (HP:0003076)1.91054671
161Aplasia/Hypoplasia of the fovea (HP:0008060)1.89534488
162Hypoplasia of the fovea (HP:0007750)1.89534488
163Myelodysplasia (HP:0002863)1.89106057
164Progressive macrocephaly (HP:0004481)1.88794953
165Sandal gap (HP:0001852)1.87761104
166Abnormal atrioventricular conduction (HP:0005150)1.87742730
167Sloping forehead (HP:0000340)1.86823352
168Poor suck (HP:0002033)1.83999877
169Photophobia (HP:0000613)1.83935245
170Acute encephalopathy (HP:0006846)1.83207589
171Increased CSF lactate (HP:0002490)1.81866307
172Abnormal mitochondria in muscle tissue (HP:0008316)1.81005949
173Lissencephaly (HP:0001339)1.80614475
174Broad-based gait (HP:0002136)1.78821721
175Hypomagnesemia (HP:0002917)1.76793478
176Septo-optic dysplasia (HP:0100842)1.76572522
177Congenital sensorineural hearing impairment (HP:0008527)1.75836635
178Nephrogenic diabetes insipidus (HP:0009806)1.75509717
179Hypoglycemic seizures (HP:0002173)1.75308090
180Abnormal number of erythroid precursors (HP:0012131)1.74590132
181Retinitis pigmentosa (HP:0000510)1.74567108
182Central scotoma (HP:0000603)1.74487049

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.87067483
2PLK43.99417337
3BUB13.93426791
4MUSK3.47340462
5KSR23.44479414
6LATS23.31958914
7BRAF3.15361711
8EEF2K3.02653462
9TTK2.99556395
10MAP3K92.75995191
11NEK22.75298014
12MAP3K62.68877722
13ERBB42.66293173
14ARAF2.64611146
15BMPR1B2.58721292
16ADRBK22.57173067
17RAF12.54688014
18TRIM282.52015762
19WNK32.50227657
20TNIK2.46966823
21LATS12.45481745
22ZAK2.29431015
23INSRR2.25925508
24TAOK12.18894281
25GRK12.16205806
26CDK192.14919618
27STK38L2.13399155
28STK161.97799324
29MAPKAPK31.93934494
30AKT31.93832118
31MAP3K131.90236842
32TAOK31.89058235
33STK31.86402722
34CDC71.84987589
35MOS1.82606834
36OXSR11.77898549
37PLK11.75256738
38PAK61.74711254
39WNK41.74501732
40WEE11.67422522
41ACVR1B1.65508233
42KSR11.63302766
43CHEK21.53638209
44BRSK21.53464897
45CDK81.48873800
46MAP4K21.48678261
47CASK1.45385108
48LMTK21.42186020
49MELK1.37460847
50BRSK11.35115688
51PLK31.34168926
52TLK11.31845488
53EIF2AK11.29219902
54STK391.21499820
55PHKG11.19000451
56PHKG21.19000451
57PLK21.16757742
58BRD41.13088367
59NME11.10275181
60MAPKAPK51.08941367
61PINK11.08744662
62PRKCE1.07294965
63AURKB1.03727580
64MKNK21.03258944
65DYRK21.03050919
66CAMKK20.96684493
67PDK20.92982555
68AURKA0.89645219
69PKN10.89583700
70MAP3K80.86829885
71ADRBK10.85692257
72CDK90.85015301
73DYRK30.82949456
74PRKD30.82724537
75PRKCG0.82543935
76MARK30.82358218
77STK100.81152735
78SRPK10.80914760
79CDK30.80088211
80MAPK130.79974833
81PRKG20.79204786
82RPS6KA40.77775913
83BMPR20.76986727
84NTRK30.76326294
85PRKAA10.75287020
86PBK0.75170068
87TXK0.73899022
88CSNK1G30.72867530
89CCNB10.71648061
90TGFBR10.70734309
91CSNK1G10.69074086
92MARK10.67878114
93CHEK10.63939198
94CDK70.62438763
95STK380.62216001
96CSNK1G20.61626225
97PRKAA20.61574125
98ABL20.59933052
99PRKG10.59047758
100PIM20.58912083
101RPS6KB20.58872078
102BCKDK0.58416785
103CDK40.57468567
104CSNK1A10.57445342
105GSK3A0.56603870
106FLT30.54759108
107TRPM70.54180878
108CSNK1A1L0.51908599
109MKNK10.51552335
110PAK10.51354052
111PRKACA0.51250320
112MARK20.51121920
113MAPK110.50821831
114MAP2K70.49968297
115STK240.49836387
116GRK50.48815627
117CSNK2A10.48569980
118PRKCQ0.47472238
119CAMK2A0.47275342
120NEK60.46700920
121PRKD20.45403406
122WNK10.44418691
123TNK20.43917842
124FGFR20.42588960
125EPHA40.42425757
126VRK10.42214923
127CAMK10.40959845
128CDK20.40590902
129TIE10.40452909
130KDR0.39834387
131PTK2B0.39600774
132ATM0.39275955
133MST40.39014984
134NEK10.37871636
135IKBKB0.37705209
136PRKCI0.37079838
137CDK10.36100148
138VRK20.36049483
139MAP3K50.34932414
140NEK90.34129932
141ATR0.29714286
142NUAK10.29323059
143MAP2K10.28993990
144TYRO30.28717837
145PDK40.28573117
146PDK30.28573117
147DMPK0.28055672
148PAK30.26444889
149TESK20.23564482
150MAP3K40.20375048
151CDK150.19666131
152EIF2AK30.16223566
153CDK180.15774742
154JAK20.15457456
155PIM10.15254498
156CDK11A0.14987326
157MAPK100.13077458
158CSNK1E0.11230416
159SGK20.10913351
160STK110.09562919

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007507.74790107
2Cell cycle_Homo sapiens_hsa041104.08353005
3RNA polymerase_Homo sapiens_hsa030203.80301494
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.32929428
5Basal transcription factors_Homo sapiens_hsa030223.16086271
6Phototransduction_Homo sapiens_hsa047442.89562962
7RNA degradation_Homo sapiens_hsa030182.65348191
8RNA transport_Homo sapiens_hsa030132.61443864
9Circadian rhythm_Homo sapiens_hsa047102.33240757
10Folate biosynthesis_Homo sapiens_hsa007902.32837018
11Taste transduction_Homo sapiens_hsa047422.30138001
12Oocyte meiosis_Homo sapiens_hsa041142.28038871
13Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.26974858
14Ovarian steroidogenesis_Homo sapiens_hsa049132.14677756
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.11921836
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.11042432
17p53 signaling pathway_Homo sapiens_hsa041152.06112499
18Homologous recombination_Homo sapiens_hsa034402.02494335
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.99275549
20Glycerophospholipid metabolism_Homo sapiens_hsa005641.95498581
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.94515538
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.84657664
23Fanconi anemia pathway_Homo sapiens_hsa034601.82457786
24Linoleic acid metabolism_Homo sapiens_hsa005911.73262658
25Olfactory transduction_Homo sapiens_hsa047401.71813466
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68676040
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68601115
28Pyrimidine metabolism_Homo sapiens_hsa002401.67519250
29Nicotine addiction_Homo sapiens_hsa050331.63852450
30Nitrogen metabolism_Homo sapiens_hsa009101.63588417
31Fatty acid biosynthesis_Homo sapiens_hsa000611.61833881
32DNA replication_Homo sapiens_hsa030301.57106447
33Butanoate metabolism_Homo sapiens_hsa006501.56079961
34Base excision repair_Homo sapiens_hsa034101.55968681
35Ribosome_Homo sapiens_hsa030101.55443742
36Regulation of autophagy_Homo sapiens_hsa041401.51760933
37Oxidative phosphorylation_Homo sapiens_hsa001901.49104300
38Cardiac muscle contraction_Homo sapiens_hsa042601.48995460
39Caffeine metabolism_Homo sapiens_hsa002321.47773154
40Parkinsons disease_Homo sapiens_hsa050121.45641144
41Nucleotide excision repair_Homo sapiens_hsa034201.43028851
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38552647
43Ether lipid metabolism_Homo sapiens_hsa005651.37268748
44Purine metabolism_Homo sapiens_hsa002301.37191112
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.35914651
46Vitamin digestion and absorption_Homo sapiens_hsa049771.34579522
47Protein export_Homo sapiens_hsa030601.32849147
48Huntingtons disease_Homo sapiens_hsa050161.30918440
49Morphine addiction_Homo sapiens_hsa050321.28638358
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.27086485
51Sulfur metabolism_Homo sapiens_hsa009201.26827844
52Insulin secretion_Homo sapiens_hsa049111.25351822
53Mismatch repair_Homo sapiens_hsa034301.24833124
54Pancreatic cancer_Homo sapiens_hsa052121.16963354
55mRNA surveillance pathway_Homo sapiens_hsa030151.13655272
56TGF-beta signaling pathway_Homo sapiens_hsa043501.08115036
57Serotonergic synapse_Homo sapiens_hsa047261.02981985
58Pentose phosphate pathway_Homo sapiens_hsa000300.98135973
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.96724785
60Selenocompound metabolism_Homo sapiens_hsa004500.96052116
61ABC transporters_Homo sapiens_hsa020100.95743147
62GABAergic synapse_Homo sapiens_hsa047270.94377010
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94038372
64Choline metabolism in cancer_Homo sapiens_hsa052310.92701065
65GnRH signaling pathway_Homo sapiens_hsa049120.92616823
66Spliceosome_Homo sapiens_hsa030400.87726713
67Prolactin signaling pathway_Homo sapiens_hsa049170.87578149
68Dorso-ventral axis formation_Homo sapiens_hsa043200.85042422
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84112367
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83716336
71Renal cell carcinoma_Homo sapiens_hsa052110.83499331
72FoxO signaling pathway_Homo sapiens_hsa040680.80434597
73Biosynthesis of amino acids_Homo sapiens_hsa012300.79354084
74MicroRNAs in cancer_Homo sapiens_hsa052060.76124121
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.75448310
76Tryptophan metabolism_Homo sapiens_hsa003800.74761015
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74522991
78Steroid biosynthesis_Homo sapiens_hsa001000.72742002
79Circadian entrainment_Homo sapiens_hsa047130.71786743
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71725030
81Non-homologous end-joining_Homo sapiens_hsa034500.71315834
82Colorectal cancer_Homo sapiens_hsa052100.71186149
83Epstein-Barr virus infection_Homo sapiens_hsa051690.70421303
84Mineral absorption_Homo sapiens_hsa049780.69592517
85Chemical carcinogenesis_Homo sapiens_hsa052040.69265836
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68628700
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67441275
88Retinol metabolism_Homo sapiens_hsa008300.67235178
89Alzheimers disease_Homo sapiens_hsa050100.66885017
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66720623
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.65763192
92VEGF signaling pathway_Homo sapiens_hsa043700.64822774
93Glutamatergic synapse_Homo sapiens_hsa047240.64423911
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64173544
95Inositol phosphate metabolism_Homo sapiens_hsa005620.60873991
96Hippo signaling pathway_Homo sapiens_hsa043900.60207433
97Propanoate metabolism_Homo sapiens_hsa006400.60172682
98mTOR signaling pathway_Homo sapiens_hsa041500.57944597
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57872863
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57835980
101Small cell lung cancer_Homo sapiens_hsa052220.56934350
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54446347
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50710263
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50646221
105Peroxisome_Homo sapiens_hsa041460.49530936
106Herpes simplex infection_Homo sapiens_hsa051680.46853937
107Cocaine addiction_Homo sapiens_hsa050300.46124552
108beta-Alanine metabolism_Homo sapiens_hsa004100.45733117
109Calcium signaling pathway_Homo sapiens_hsa040200.45705763
110Bile secretion_Homo sapiens_hsa049760.44433556
111Hepatitis B_Homo sapiens_hsa051610.44017715
112Endometrial cancer_Homo sapiens_hsa052130.43915380
113Sulfur relay system_Homo sapiens_hsa041220.43532677
114Thyroid cancer_Homo sapiens_hsa052160.41793652
115Salivary secretion_Homo sapiens_hsa049700.41641628
116Collecting duct acid secretion_Homo sapiens_hsa049660.41283396
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40456464
118Arachidonic acid metabolism_Homo sapiens_hsa005900.39825633
119Proteasome_Homo sapiens_hsa030500.39399968
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38518431
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37609054
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37472943
123Bladder cancer_Homo sapiens_hsa052190.37380823
124Prostate cancer_Homo sapiens_hsa052150.36818275
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35601923
126Glycerolipid metabolism_Homo sapiens_hsa005610.35412124
127Other glycan degradation_Homo sapiens_hsa005110.35039107
128Dopaminergic synapse_Homo sapiens_hsa047280.35023565
129Arginine and proline metabolism_Homo sapiens_hsa003300.35000500
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.33567157
131Arginine biosynthesis_Homo sapiens_hsa002200.33562082
132Amphetamine addiction_Homo sapiens_hsa050310.33119495
133Sphingolipid metabolism_Homo sapiens_hsa006000.32209284
134cAMP signaling pathway_Homo sapiens_hsa040240.32118452
135Non-small cell lung cancer_Homo sapiens_hsa052230.31222168
136Long-term depression_Homo sapiens_hsa047300.30778086
137One carbon pool by folate_Homo sapiens_hsa006700.30713542
138HTLV-I infection_Homo sapiens_hsa051660.30273703
139Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29449888
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29389725
141Chronic myeloid leukemia_Homo sapiens_hsa052200.26693069
142Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25787805
143Notch signaling pathway_Homo sapiens_hsa043300.24375312
144Viral carcinogenesis_Homo sapiens_hsa052030.24352066
145Estrogen signaling pathway_Homo sapiens_hsa049150.23206714
146Adherens junction_Homo sapiens_hsa045200.22017425
147Ras signaling pathway_Homo sapiens_hsa040140.20943182
148Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18490141
149Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16010517
150AMPK signaling pathway_Homo sapiens_hsa041520.14832961
151Melanoma_Homo sapiens_hsa052180.12021746
152Phosphatidylinositol signaling system_Homo sapiens_hsa040700.11678960
153Metabolic pathways_Homo sapiens_hsa011000.11418733
154Hedgehog signaling pathway_Homo sapiens_hsa043400.11260958
155Jak-STAT signaling pathway_Homo sapiens_hsa046300.11000448
156Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10755282
157ErbB signaling pathway_Homo sapiens_hsa040120.10097321
158Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.09650801
159MAPK signaling pathway_Homo sapiens_hsa040100.07055735
160Apoptosis_Homo sapiens_hsa042100.06066517
161Glioma_Homo sapiens_hsa052140.05714515

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