ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of somitogenesis (GO:0014807)	9.10268278
2	mesenchymal cell differentiation involved in kidney development (GO:0072161)	7.12112714
3	mesenchymal cell differentiation involved in renal system development (GO:2001012)	7.12112714
4	prenylation (GO:0097354)	6.79141558
5	protein prenylation (GO:0018342)	6.79141558
6	lymphangiogenesis (GO:0001946)	6.69643139
7	positive regulation of endothelial cell differentiation (GO:0045603)	6.67282823
8	retina vasculature morphogenesis in camera-type eye (GO:0061299)	6.32951134
9	blood vessel maturation (GO:0001955)	5.89170576
10	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	5.80813678
11	regulation of retinoic acid receptor signaling pathway (GO:0048385)	5.15237918
12	regulation of endothelial cell differentiation (GO:0045601)	5.12884112
13	G-protein coupled receptor internalization (GO:0002031)	4.82342998
14	endothelial cell differentiation (GO:0045446)	4.80431126
15	sulfation (GO:0051923)	4.73529371
16	positive regulation of digestive system process (GO:0060456)	4.52719218
17	membrane protein ectodomain proteolysis (GO:0006509)	4.43129672
18	neuron remodeling (GO:0016322)	4.25434668
19	dermatan sulfate biosynthetic process (GO:0030208)	4.25270457
20	endothelium development (GO:0003158)	4.19973273
21	regulation of cardiac muscle cell contraction (GO:0086004)	4.15876376
22	drinking behavior (GO:0042756)	4.10600682
23	dermatan sulfate metabolic process (GO:0030205)	4.01679971
24	positive regulation of systemic arterial blood pressure (GO:0003084)	3.99663266
25	negative regulation of systemic arterial blood pressure (GO:0003085)	3.95576662
26	response to epinephrine (GO:0071871)	3.95116638
27	DNA integration (GO:0015074)	3.94423232
28	positive regulation of cardiac muscle cell differentiation (GO:2000727)	3.92488759
29	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.92463319
30	response to pheromone (GO:0019236)	3.89500643
31	dendritic spine morphogenesis (GO:0060997)	3.87382383
32	positive regulation of RNA splicing (GO:0033120)	3.85683167
33	positive regulation of p38MAPK cascade (GO:1900745)	3.85103277
34	positive regulation of heart rate (GO:0010460)	3.84624202
35	positive regulation of cAMP-mediated signaling (GO:0043950)	3.77627522
36	plasma membrane repair (GO:0001778)	3.75148459
37	response to oxygen radical (GO:0000305)	3.75029612
38	regulation of actin filament-based movement (GO:1903115)	3.74715297
39	peristalsis (GO:0030432)	3.74055740
40	phagocytosis, recognition (GO:0006910)	3.69938723
41	cilium or flagellum-dependent cell motility (GO:0001539)	3.65500773
42	regulation of urine volume (GO:0035809)	3.64928818
43	negative regulation of blood vessel endothelial cell migration (GO:0043537)	3.56376385
44	regulation of DNA damage checkpoint (GO:2000001)	3.53482402
45	adrenergic receptor signaling pathway (GO:0071875)	3.47247615
46	post-anal tail morphogenesis (GO:0036342)	3.43416643
47	phasic smooth muscle contraction (GO:0014821)	3.42652686
48	negative regulation of actin filament bundle assembly (GO:0032232)	3.42215873
49	thalamus development (GO:0021794)	3.39743873
50	pathway-restricted SMAD protein phosphorylation (GO:0060389)	3.39073307
51	positive regulation of muscle hypertrophy (GO:0014742)	3.38264924
52	positive regulation of cardiac muscle hypertrophy (GO:0010613)	3.38264924
53	establishment of endothelial barrier (GO:0061028)	3.36099755
54	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	3.30356246
55	negative regulation of platelet activation (GO:0010544)	3.28438946
56	cellular response to epinephrine stimulus (GO:0071872)	3.27814685
57	embryonic heart tube development (GO:0035050)	3.25913171
58	wound healing, spreading of epidermal cells (GO:0035313)	3.24639383
59	positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)	3.23637591
60	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.20661257
61	bone remodeling (GO:0046849)	3.17673000
62	Notch signaling involved in heart development (GO:0061314)	3.10678260
63	superoxide anion generation (GO:0042554)	3.08489920
64	temperature homeostasis (GO:0001659)	3.04561509
65	negative regulation of DNA biosynthetic process (GO:2000279)	3.02415427
66	endothelial cell proliferation (GO:0001935)	3.00491924
67	gland morphogenesis (GO:0022612)	2.99011513
68	regulation of sequestering of triglyceride (GO:0010889)	2.98291547
69	regulation of cardiac muscle cell differentiation (GO:2000725)	2.97098921
70	platelet-derived growth factor receptor signaling pathway (GO:0048008)	2.94082909
71	regulation of chemokine-mediated signaling pathway (GO:0070099)	2.94039435
72	mRNA transcription from RNA polymerase II promoter (GO:0042789)	2.94012650
73	cardiac muscle tissue development (GO:0048738)	2.91827082
74	negative regulation of smooth muscle contraction (GO:0045986)	2.91360196
75	positive regulation of heart contraction (GO:0045823)	2.89819196
76	regulation of sarcomere organization (GO:0060297)	2.88278743
77	negative regulation of endothelial cell migration (GO:0010596)	2.86185270
78	left/right pattern formation (GO:0060972)	2.84027811
79	collecting duct development (GO:0072044)	2.79130359
80	leukotriene biosynthetic process (GO:0019370)	2.73648403
81	regulation of p38MAPK cascade (GO:1900744)	2.71894589
82	nephron epithelium development (GO:0072009)	2.68916242
83	vasculogenesis (GO:0001570)	2.68202782
84	membrane protein proteolysis (GO:0033619)	2.67233633
85	chemosensory behavior (GO:0007635)	2.65799114
86	regulation of hippo signaling (GO:0035330)	2.64562545
87	endoderm formation (GO:0001706)	2.62510915
88	flavonoid metabolic process (GO:0009812)	2.61951418
89	activin receptor signaling pathway (GO:0032924)	2.59070380
90	viral mRNA export from host cell nucleus (GO:0046784)	2.57750731
91	replicative senescence (GO:0090399)	2.55148188
92	blood vessel endothelial cell migration (GO:0043534)	2.53919852
93	vocalization behavior (GO:0071625)	2.53617199
94	negative regulation of multicellular organism growth (GO:0040015)	2.53489783
95	regulation of glomerulus development (GO:0090192)	2.52480596
96	regulation of cardiac muscle hypertrophy (GO:0010611)	2.49431985
97	multicellular organismal movement (GO:0050879)	2.48863244
98	musculoskeletal movement (GO:0050881)	2.48863244
99	peptide catabolic process (GO:0043171)	2.48822484
100	mRNA transcription (GO:0009299)	2.48140476

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	STAT6_21828071_ChIP-Seq_BEAS2B_Human	5.70624633
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.26993846
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.07480234
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.01432322
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.89271181
6	GATA2_21666600_ChIP-Seq_HMVEC_Human	3.60125219
7	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.76968476
8	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.71659666
9	VDR_22108803_ChIP-Seq_LS180_Human	2.68686634
10	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.53127596
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.44279098
12	GBX2_23144817_ChIP-Seq_PC3_Human	2.25609485
13	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.96702215
14	TP53_16413492_ChIP-PET_HCT116_Human	1.96235214
15	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.95119364
16	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.75371727
17	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.74122313
18	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.74122313
19	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.69605159
20	AR_21572438_ChIP-Seq_LNCaP_Human	1.66452859
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.66423292
22	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.65380775
23	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.58718548
24	CJUN_26792858_Chip-Seq_BT549_Human	1.57489161
25	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.57068465
26	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.55785236
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.54288780
28	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.53233945
29	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.50745268
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.45387332
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.43754433
32	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.41951945
33	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.40409651
34	FUS_26573619_Chip-Seq_HEK293_Human	1.38485006
35	DROSHA_22980978_ChIP-Seq_HELA_Human	1.36501771
36	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.36214204
37	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.36003239
38	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.35837319
39	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.35491781
40	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.34610255
41	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.33836262
42	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.30698036
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.29897966
44	P300_19829295_ChIP-Seq_ESCs_Human	1.26063036
45	GATA1_19941826_ChIP-Seq_K562_Human	1.25176413
46	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.24660180
47	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.24444984
48	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.23734349
49	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.21710791
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.20847395
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.20847395
52	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.19881222
53	BCAT_22108803_ChIP-Seq_LS180_Human	1.19020370
54	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.18360304
55	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.17990878
56	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.16813590
57	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.12879676
58	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.12282607
59	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.12123093
60	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.11858393
61	GATA2_19941826_ChIP-Seq_K562_Human	1.11699111
62	GATA1_22025678_ChIP-Seq_K562_Human	1.11339252
63	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.09727602
64	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08541064
65	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.08330518
66	RXR_22108803_ChIP-Seq_LS180_Human	1.08291743
67	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.06781016
68	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.05909294
69	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.05196963
70	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.03347008
71	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.03347008
72	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.03347008
73	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.03241506
74	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.02713595
75	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.02323193
76	SMAD4_21799915_ChIP-Seq_A2780_Human	1.02218945
77	EWS_26573619_Chip-Seq_HEK293_Human	1.01895586
78	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.00228082
79	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.99765259
80	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99596376
81	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.97871226
82	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.95861672
83	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.95416268
84	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94349469
85	RNF2_27304074_Chip-Seq_NSC_Mouse	0.93628268
86	CDX2_22108803_ChIP-Seq_LS180_Human	0.93054593
87	TCF4_23295773_ChIP-Seq_U87_Human	0.92432095
88	STAT3_23295773_ChIP-Seq_U87_Human	0.92398331
89	RUNX2_22187159_ChIP-Seq_PCA_Human	0.91498282
90	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.91429064
91	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.90955836
92	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.90460757
93	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.89455691
94	LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.88687614
95	KDM2B_26808549_Chip-Seq_REH_Human	0.87011066
96	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.86808876
97	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.86802392
98	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.86701572
99	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.85883841
100	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.85816546

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010368_abnormal_lymphatic_system	6.38986631
2	MP0001879_abnormal_lymphatic_vessel	6.35579407
3	MP0005409_darkened_coat_color	4.29347486
4	MP0002138_abnormal_hepatobiliary_system	3.13428226
5	MP0004272_abnormal_basement_membrane	3.10233955
6	MP0003567_abnormal_fetal_cardiomyocyte	2.81989308
7	MP0002163_abnormal_gland_morphology	2.81439864
8	MP0003279_aneurysm	2.63152160
9	MP0005167_abnormal_blood-brain_barrier	2.51690164
10	MP0003045_fibrosis	2.45875541
11	MP0004145_abnormal_muscle_electrophysio	2.35098101
12	MP0005171_absent_coat_pigmentation	2.31691061
13	MP0006138_congestive_heart_failure	2.31375514
14	MP0002638_abnormal_pupillary_reflex	2.30793999
15	MP0009384_cardiac_valve_regurgitation	2.20858531
16	MP0005385_cardiovascular_system_phenoty	2.17131349
17	MP0001544_abnormal_cardiovascular_syste	2.17131349
18	MP0008004_abnormal_stomach_pH	2.16380064
19	MP0003724_increased_susceptibility_to	2.12092198
20	MP0003828_pulmonary_edema	2.10465660
21	MP0005085_abnormal_gallbladder_physiolo	1.95787199
22	MP0005257_abnormal_intraocular_pressure	1.82988360
23	MP0002332_abnormal_exercise_endurance	1.82745062
24	MP0000465_gastrointestinal_hemorrhage	1.73529726
25	MP0005275_abnormal_skin_tensile	1.72688326
26	MP0003183_abnormal_peptide_metabolism	1.68180852
27	MP0000372_irregular_coat_pigmentation	1.67813988
28	MP0003941_abnormal_skin_development	1.61756800
29	MP0003303_peritoneal_inflammation	1.54523185
30	MP0002127_abnormal_cardiovascular_syste	1.51403100
31	MP0004264_abnormal_extraembryonic_tissu	1.47602152
32	MP0001293_anophthalmia	1.47351983
33	MP0003646_muscle_fatigue	1.45938656
34	MP0001486_abnormal_startle_reflex	1.40504175
35	MP0002972_abnormal_cardiac_muscle	1.38906766
36	MP0000249_abnormal_blood_vessel	1.36889172
37	MP0005620_abnormal_muscle_contractility	1.36002242
38	MP0003252_abnormal_bile_duct	1.33681281
39	MP0006276_abnormal_autonomic_nervous	1.31992043
40	MP0004215_abnormal_myocardial_fiber	1.28899814
41	MP0004484_altered_response_of	1.27664646
42	MP0005330_cardiomyopathy	1.26708393
43	MP0002106_abnormal_muscle_physiology	1.25239571
44	MP0002736_abnormal_nociception_after	1.23890292
45	MP0000613_abnormal_salivary_gland	1.20134537
46	MP0003091_abnormal_cell_migration	1.18441814
47	MP0004084_abnormal_cardiac_muscle	1.18070992
48	MP0000767_abnormal_smooth_muscle	1.17128283
49	MP0005379_endocrine/exocrine_gland_phen	1.16214035
50	MP0002168_other_aberrant_phenotype	1.15859866
51	MP0000343_altered_response_to	1.10975806
52	MP0005369_muscle_phenotype	1.09419729
53	MP0005464_abnormal_platelet_physiology	1.08237385
54	MP0000751_myopathy	1.05490455
55	MP0008775_abnormal_heart_ventricle	1.05371124
56	MP0000750_abnormal_muscle_regeneration	1.04020140
57	MP0001324_abnormal_eye_pigmentation	0.97190414
58	MP0008770_decreased_survivor_rate	0.96453808
59	MP0002089_abnormal_postnatal_growth/wei	0.94557437
60	MP0002128_abnormal_blood_circulation	0.94224973
61	MP0001485_abnormal_pinna_reflex	0.93646625
62	MP0009046_muscle_twitch	0.93108994
63	MP0008438_abnormal_cutaneous_collagen	0.92612103
64	MP0000371_diluted_coat_color	0.92564307
65	MP0001270_distended_abdomen	0.91526315
66	MP0003191_abnormal_cellular_cholesterol	0.91524185
67	MP0005551_abnormal_eye_electrophysiolog	0.91473276
68	MP0004085_abnormal_heartbeat	0.86226572
69	MP0009278_abnormal_bone_marrow	0.85099929
70	MP0000569_abnormal_digit_pigmentation	0.84401793
71	MP0004510_myositis	0.83154103
72	MP0000163_abnormal_cartilage_morphology	0.78915793
73	MP0002102_abnormal_ear_morphology	0.78612047
74	MP0002796_impaired_skin_barrier	0.78378901
75	MP0002108_abnormal_muscle_morphology	0.77376826
76	MP0008872_abnormal_physiological_respon	0.75932238
77	MP0000015_abnormal_ear_pigmentation	0.75764540
78	MP0003959_abnormal_lean_body	0.73553687
79	MP0003868_abnormal_feces_composition	0.72092868
80	MP0000467_abnormal_esophagus_morphology	0.71925208
81	MP0002090_abnormal_vision	0.71296073
82	MP0002998_abnormal_bone_remodeling	0.71146326
83	MP0003948_abnormal_gas_homeostasis	0.70699070
84	MP0002971_abnormal_brown_adipose	0.68766273
85	MP0009764_decreased_sensitivity_to	0.68141409
86	MP0003638_abnormal_response/metabolism_	0.67079773
87	MP0005595_abnormal_vascular_smooth	0.66698808
88	MP0003693_abnormal_embryo_hatching	0.65590700
89	MP0001614_abnormal_blood_vessel	0.65411403
90	MP0001299_abnormal_eye_distance/	0.64322590
91	MP0004142_abnormal_muscle_tone	0.63908038
92	MP0010630_abnormal_cardiac_muscle	0.63357091
93	MP0001784_abnormal_fluid_regulation	0.63240999
94	MP0001968_abnormal_touch/_nociception	0.62500649
95	MP0003137_abnormal_impulse_conducting	0.61480901
96	MP0005083_abnormal_biliary_tract	0.61119715
97	MP0004036_abnormal_muscle_relaxation	0.60472920
98	MP0004147_increased_porphyrin_level	0.60460637
99	MP0005388_respiratory_system_phenotype	0.58705258
100	MP0002133_abnormal_respiratory_system	0.58705258

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Asymmetry of the thorax (HP:0001555)	6.92528521
2	Tongue fasciculations (HP:0001308)	6.06926092
3	Broad ribs (HP:0000885)	6.03214845
4	Muscle fibrillation (HP:0010546)	5.94981071
5	Fibular aplasia (HP:0002990)	5.67560800
6	Abnormality of the lumbar spine (HP:0100712)	5.51043321
7	Anomalous pulmonary venous return (HP:0010772)	5.42696081
8	Spontaneous hematomas (HP:0007420)	5.33749861
9	Thoracic kyphosis (HP:0002942)	5.03673386
10	Aortic regurgitation (HP:0001659)	4.94439824
11	Abnormality of the pulmonary veins (HP:0011718)	4.70946527
12	Subacute progressive viral hepatitis (HP:0006572)	4.48044405
13	Renal cortical cysts (HP:0000803)	4.43077920
14	Slow saccadic eye movements (HP:0000514)	4.32664047
15	Oral leukoplakia (HP:0002745)	4.18674670
16	Thickened calvaria (HP:0002684)	3.99352535
17	Subcapsular cataract (HP:0000523)	3.88262844
18	J-shaped sella turcica (HP:0002680)	3.86174931
19	Difficulty running (HP:0009046)	3.83676134
20	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	3.77344426
21	Rough bone trabeculation (HP:0100670)	3.68509757
22	Abnormality of the thoracic spine (HP:0100711)	3.67412889
23	Spontaneous abortion (HP:0005268)	3.54030815
24	Nonimmune hydrops fetalis (HP:0001790)	3.46487255
25	Bifid uvula (HP:0000193)	3.39729422
26	Natal tooth (HP:0000695)	3.36976788
27	Impaired smooth pursuit (HP:0007772)	3.32727235
28	Esophageal varix (HP:0002040)	3.32318128
29	Lymphangioma (HP:0100764)	3.25620379
30	Hematochezia (HP:0002573)	3.18464297
31	Abnormality of the odontoid process (HP:0003310)	3.17066494
32	Increased mean platelet volume (HP:0011877)	3.14981597
33	Partial agenesis of the corpus callosum (HP:0001338)	3.12918947
34	Thrombocytosis (HP:0001894)	3.03706634
35	Microtia (HP:0008551)	3.02719697
36	Abnormality of the renal cortex (HP:0011035)	3.01409173
37	Vertebral arch anomaly (HP:0008438)	3.01023610
38	Pigmentary retinal degeneration (HP:0001146)	3.00101496
39	Conjunctival telangiectasia (HP:0000524)	2.93170521
40	Absent eyebrow (HP:0002223)	2.88418179
41	Abnormal platelet volume (HP:0011876)	2.88266935
42	Abnormal trabecular bone morphology (HP:0100671)	2.77729339
43	Portal hypertension (HP:0001409)	2.74520095
44	Fibular hypoplasia (HP:0003038)	2.67854688
45	Nasal speech (HP:0001611)	2.65162023
46	Delayed closure of the anterior fontanelle (HP:0001476)	2.61812145
47	Conjugated hyperbilirubinemia (HP:0002908)	2.60343291
48	Abnormality of ocular smooth pursuit (HP:0000617)	2.58380039
49	Anal stenosis (HP:0002025)	2.53513078
50	Cavernous hemangioma (HP:0001048)	2.53156995
51	Polar cataract (HP:0010696)	2.48010528
52	Hemiplegia (HP:0002301)	2.47252757
53	Abnormality of the hepatic vasculature (HP:0006707)	2.46516505
54	Bilateral sensorineural hearing impairment (HP:0008619)	2.45461373
55	Absent eyelashes (HP:0000561)	2.45359559
56	Tracheomalacia (HP:0002779)	2.43648783
57	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.41478647
58	Diastasis recti (HP:0001540)	2.41129619
59	Genetic anticipation (HP:0003743)	2.38881889
60	Absent hand (HP:0004050)	2.36862606
61	Adactyly (HP:0009776)	2.33813128
62	Wide intermamillary distance (HP:0006610)	2.33203650
63	Nephronophthisis (HP:0000090)	2.32506491
64	Woolly hair (HP:0002224)	2.31222620
65	Myelomeningocele (HP:0002475)	2.27789384
66	Hepatocellular carcinoma (HP:0001402)	2.21345613
67	Hyperkalemia (HP:0002153)	2.19717181
68	Thoracolumbar scoliosis (HP:0002944)	2.15377629
69	Viral hepatitis (HP:0006562)	2.14341704
70	Visual hallucinations (HP:0002367)	2.12454045
71	Micronodular cirrhosis (HP:0001413)	2.12361521
72	Fair hair (HP:0002286)	2.11031560
73	Joint hemorrhage (HP:0005261)	2.10208697
74	Abnormality of the renal medulla (HP:0100957)	2.08424016
75	Curly hair (HP:0002212)	2.05862892
76	Azoospermia (HP:0000027)	2.01801752
77	Abnormality of saccadic eye movements (HP:0000570)	2.01030021
78	Tinnitus (HP:0000360)	2.00945011
79	Muscle fiber splitting (HP:0003555)	1.94821446
80	Clumsiness (HP:0002312)	1.89943384
81	Craniofacial hyperostosis (HP:0004493)	1.89552443
82	Lipoatrophy (HP:0100578)	1.89138415
83	Bulbous nose (HP:0000414)	1.88757061
84	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.83797518
85	Advanced eruption of teeth (HP:0006288)	1.83643303
86	Porencephaly (HP:0002132)	1.83607686
87	Stenosis of the external auditory canal (HP:0000402)	1.82577884
88	Limb ataxia (HP:0002070)	1.76268737
89	Cranial hyperostosis (HP:0004437)	1.73334220
90	Hemorrhage of the eye (HP:0011885)	1.70368278
91	Abnormality of methionine metabolism (HP:0010901)	1.69920287
92	Microcytic anemia (HP:0001935)	1.68966472
93	Abnormality of the peritoneum (HP:0002585)	1.65878515
94	Flat acetabular roof (HP:0003180)	1.65793384
95	Generalized hypopigmentation of hair (HP:0011358)	1.64442126
96	Hepatocellular necrosis (HP:0001404)	1.64392682
97	Abnormality of the anterior chamber (HP:0000593)	1.64090020
98	Hypotrichosis (HP:0001006)	1.63801012
99	Abnormal platelet function (HP:0011869)	1.63407922
100	Impaired platelet aggregation (HP:0003540)	1.63407922

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	9.38169082
2	BLK	5.12455045
3	TEC	3.46338808
4	TNIK	2.54554444
5	TGFBR2	2.43536390
6	FRK	2.38421218
7	BMPR1B	2.19680936
8	TAOK3	2.07700004
9	ITK	1.94575954
10	PIM2	1.84009204
11	GRK5	1.81002006
12	GRK7	1.75925312
13	GRK1	1.71935593
14	LATS2	1.50656970
15	PTK2	1.48243767
16	CLK1	1.46967288
17	KDR	1.37371459
18	SGK2	1.28630546
19	CAMK4	1.22960598
20	PTK2B	1.22458836
21	MAPK7	1.16057448
22	FES	1.15838103
23	MAP2K3	1.15400229
24	PIK3CG	1.15145672
25	TGFBR1	1.09977299
26	ARAF	1.09968087
27	TAOK1	1.04349245
28	EPHA2	0.99954022
29	MATK	0.98905329
30	OBSCN	0.98245193
31	MAP3K3	0.96608545
32	LMTK2	0.96460374
33	NEK9	0.93662108
34	BTK	0.89176512
35	SGK3	0.83985271
36	SGK223	0.80865731
37	SGK494	0.80865731
38	EPHB2	0.80170758
39	CDK3	0.76372840
40	CDK8	0.76039924
41	PRKD1	0.73185818
42	ADRBK2	0.72284649
43	MAP3K10	0.71076849
44	DDR2	0.70574086
45	RPS6KA5	0.69765147
46	FER	0.68859584
47	TRPM7	0.67873748
48	PDK2	0.62918560
49	RPS6KA6	0.61629629
50	SYK	0.61138104
51	PHKG2	0.59221980
52	PHKG1	0.59221980
53	HCK	0.58988086
54	IGF1R	0.57780102
55	FGFR1	0.56919778
56	MOS	0.56837457
57	TTN	0.56560975
58	MAPKAPK3	0.55911383
59	STK4	0.54805185
60	ADRBK1	0.54796189
61	ZAK	0.52606737
62	FGR	0.52203671
63	MAPK12	0.47689537
64	BRAF	0.46689582
65	ABL2	0.44680826
66	LYN	0.44004784
67	FLT3	0.42827583
68	INSR	0.42249076
69	MYLK	0.41548361
70	RPS6KC1	0.41273619
71	RPS6KL1	0.41273619
72	PDGFRB	0.40636503
73	CAMK2D	0.39983669
74	DYRK1B	0.39840976
75	ZAP70	0.39602436
76	DAPK3	0.39548191
77	NTRK1	0.39411129
78	PRKAA2	0.38925447
79	EGFR	0.37674216
80	CAMK2G	0.37533771
81	MARK1	0.36965952
82	PIM1	0.36556641
83	CSK	0.36229346
84	IKBKE	0.36159024
85	DYRK3	0.34986227
86	GSK3A	0.34307532
87	MELK	0.34240632
88	MAP3K7	0.34137987
89	OXSR1	0.33242546
90	IKBKB	0.31694878
91	FYN	0.31458242
92	CAMK2B	0.31399126
93	KIT	0.31305920
94	MAPK4	0.30436334
95	PRKG2	0.30411419
96	AKT1	0.29984078
97	ABL1	0.29512216
98	BMX	0.28828940
99	SGK1	0.28212872
100	LCK	0.27563000

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Selenocompound metabolism_Homo sapiens_hsa00450	6.14724819
2	Caffeine metabolism_Homo sapiens_hsa00232	3.62263714
3	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.97638435
4	Dilated cardiomyopathy_Homo sapiens_hsa05414	2.61325627
5	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	2.53840819
6	ABC transporters_Homo sapiens_hsa02010	2.37701398
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.26433756
8	Homologous recombination_Homo sapiens_hsa03440	2.13795037
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.10482512
10	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.88494957
11	Olfactory transduction_Homo sapiens_hsa04740	1.82166059
12	Renin secretion_Homo sapiens_hsa04924	1.77537697
13	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.69228062
14	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.66194059
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.58882306
16	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.56994225
17	Taste transduction_Homo sapiens_hsa04742	1.50547224
18	Platelet activation_Homo sapiens_hsa04611	1.50093227
19	ECM-receptor interaction_Homo sapiens_hsa04512	1.48258998
20	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.47189637
21	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.36141087
22	Morphine addiction_Homo sapiens_hsa05032	1.29132163
23	Serotonergic synapse_Homo sapiens_hsa04726	1.28106868
24	Glutamatergic synapse_Homo sapiens_hsa04724	1.28038714
25	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.26565666
26	Salivary secretion_Homo sapiens_hsa04970	1.26038994
27	cAMP signaling pathway_Homo sapiens_hsa04024	1.25640687
28	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.25379909
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.22484263
30	Gap junction_Homo sapiens_hsa04540	1.16926349
31	Nicotine addiction_Homo sapiens_hsa05033	1.16512032
32	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.01091235
33	Malaria_Homo sapiens_hsa05144	0.99856894
34	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.99119447
35	Long-term depression_Homo sapiens_hsa04730	0.97396625
36	Small cell lung cancer_Homo sapiens_hsa05222	0.89421634
37	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.88366068
38	Calcium signaling pathway_Homo sapiens_hsa04020	0.84859842
39	Sphingolipid metabolism_Homo sapiens_hsa00600	0.84713178
40	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.84430742
41	Alcoholism_Homo sapiens_hsa05034	0.83862759
42	Circadian entrainment_Homo sapiens_hsa04713	0.81731477
43	Ras signaling pathway_Homo sapiens_hsa04014	0.80197746
44	Focal adhesion_Homo sapiens_hsa04510	0.78508983
45	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.76942272
46	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.76323345
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73298931
48	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.72938043
49	Cardiac muscle contraction_Homo sapiens_hsa04260	0.72745108
50	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.72317769
51	Complement and coagulation cascades_Homo sapiens_hsa04610	0.72299751
52	MAPK signaling pathway_Homo sapiens_hsa04010	0.70851800
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.67766287
54	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.67652343
55	Rap1 signaling pathway_Homo sapiens_hsa04015	0.67641804
56	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.66603714
57	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.66270037
58	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.65147744
59	Melanoma_Homo sapiens_hsa05218	0.64871664
60	Fatty acid degradation_Homo sapiens_hsa00071	0.63912676
61	Apoptosis_Homo sapiens_hsa04210	0.63628776
62	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.58734717
63	PPAR signaling pathway_Homo sapiens_hsa03320	0.58397936
64	Glycerolipid metabolism_Homo sapiens_hsa00561	0.57724259
65	Chemokine signaling pathway_Homo sapiens_hsa04062	0.56265960
66	Fatty acid metabolism_Homo sapiens_hsa01212	0.55435830
67	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.53675328
68	Measles_Homo sapiens_hsa05162	0.52406094
69	Cholinergic synapse_Homo sapiens_hsa04725	0.51322508
70	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.50058568
71	Adherens junction_Homo sapiens_hsa04520	0.49054372
72	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.47959781
73	Bladder cancer_Homo sapiens_hsa05219	0.47356347
74	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.47247847
75	Pathways in cancer_Homo sapiens_hsa05200	0.46533593
76	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.46434895
77	Circadian rhythm_Homo sapiens_hsa04710	0.46118217
78	Osteoclast differentiation_Homo sapiens_hsa04380	0.45353051
79	Pancreatic secretion_Homo sapiens_hsa04972	0.43933802
80	GnRH signaling pathway_Homo sapiens_hsa04912	0.42354134
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.41862438
82	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.41845804
83	Axon guidance_Homo sapiens_hsa04360	0.39279176
84	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.39030578
85	Renin-angiotensin system_Homo sapiens_hsa04614	0.38910280
86	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.38514898
87	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.37612793
88	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.36731821
89	African trypanosomiasis_Homo sapiens_hsa05143	0.36248742
90	FoxO signaling pathway_Homo sapiens_hsa04068	0.35972086
91	Viral myocarditis_Homo sapiens_hsa05416	0.35744628
92	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.35706196
93	Tryptophan metabolism_Homo sapiens_hsa00380	0.35033351
94	Cocaine addiction_Homo sapiens_hsa05030	0.34451751
95	Melanogenesis_Homo sapiens_hsa04916	0.34332704
96	Choline metabolism in cancer_Homo sapiens_hsa05231	0.34218287
97	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.33808642
98	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.33502764
99	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.32705198
100	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.31674735

KLF17P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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