KLF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is expressed early in mammalian development and is found in many different cell types. The protein acts to bind the CACCC box found in the promoter of target genes to activate their transcription. It plays a role in many processes during development and disease including adipogenesis, embryonic erythropoiesis, epithelial integrity, inflammation and t-cell viability. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.13236806
2regulation of gamma-delta T cell differentiation (GO:0045586)4.54428958
3positive thymic T cell selection (GO:0045059)4.50736178
4detection of other organism (GO:0098543)4.31429349
5detection of bacterium (GO:0016045)4.29929734
6negative regulation of cell killing (GO:0031342)4.28390783
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.28390783
8regulation of B cell receptor signaling pathway (GO:0050855)4.22443195
9neutrophil activation involved in immune response (GO:0002283)4.19730880
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.17838697
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.17838697
12antigen processing and presentation of endogenous antigen (GO:0019883)4.15441016
13regulation of gamma-delta T cell activation (GO:0046643)4.14335271
14negative regulation of lymphocyte mediated immunity (GO:0002707)4.10501587
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.09513793
16embryonic process involved in female pregnancy (GO:0060136)4.03109654
17interferon-gamma production (GO:0032609)3.81566821
18negative regulation of T cell mediated immunity (GO:0002710)3.78486959
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.68918072
20negative regulation of leukocyte mediated immunity (GO:0002704)3.65353255
21activated T cell proliferation (GO:0050798)3.64792699
22thymic T cell selection (GO:0045061)3.62602096
23negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.62338733
24negative regulation of granulocyte differentiation (GO:0030853)3.54853452
25cellular extravasation (GO:0045123)3.53987424
26morphogenesis of an endothelium (GO:0003159)3.52868418
27endothelial tube morphogenesis (GO:0061154)3.52868418
28positive T cell selection (GO:0043368)3.52239959
29B cell receptor signaling pathway (GO:0050853)3.48444618
30T cell migration (GO:0072678)3.47920325
31negative T cell selection (GO:0043383)3.47706352
32neutrophil activation (GO:0042119)3.46931561
33negative thymic T cell selection (GO:0045060)3.43021225
34response to peptidoglycan (GO:0032494)3.40822017
35detection of external biotic stimulus (GO:0098581)3.38692324
36tolerance induction (GO:0002507)3.36376104
37regulation of alpha-beta T cell proliferation (GO:0046640)3.31922995
38positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.31239829
39respiratory burst (GO:0045730)3.29971398
40leukocyte migration involved in inflammatory response (GO:0002523)3.27334659
41regulation of T cell tolerance induction (GO:0002664)3.24943137
42positive regulation of granulocyte differentiation (GO:0030854)3.23440586
43antigen processing and presentation via MHC class Ib (GO:0002475)3.23422271
44T cell selection (GO:0045058)3.22069273
45negative regulation of T-helper cell differentiation (GO:0045623)3.18978579
46negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.18978579
47negative regulation of stress fiber assembly (GO:0051497)3.15861084
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.15697073
49regulation of regulatory T cell differentiation (GO:0045589)3.14713575
50regulation of B cell differentiation (GO:0045577)3.12166076
51response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.10384006
52response to host immune response (GO:0052572)3.10384006
53regulation of natural killer cell mediated immunity (GO:0002715)3.09793912
54regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.09793912
55regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.09394346
56granulocyte activation (GO:0036230)3.09359407
57myeloid cell activation involved in immune response (GO:0002275)3.06760520
58defense response to protozoan (GO:0042832)3.05316748
59cellular response to type I interferon (GO:0071357)3.05125942
60type I interferon signaling pathway (GO:0060337)3.05125942
61T cell homeostasis (GO:0043029)3.04893007
62response to type I interferon (GO:0034340)3.04573423
63negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.02593226
64viral transcription (GO:0019083)3.02064531
65negative regulation of interleukin-12 production (GO:0032695)3.02036006
66regulation of T cell mediated cytotoxicity (GO:0001914)3.01986063
67response to muramyl dipeptide (GO:0032495)3.01780619
68regulation of integrin activation (GO:0033623)3.01392982
69regulation of mast cell degranulation (GO:0043304)3.00603556
70negative regulation of innate immune response (GO:0045824)3.00199690
71response to host (GO:0075136)2.96404925
72response to host defenses (GO:0052200)2.96404925
73response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.96404925
74detection of biotic stimulus (GO:0009595)2.94638376
75response to interleukin-15 (GO:0070672)2.92767165
76positive regulation of B cell differentiation (GO:0045579)2.90331678
77embryonic placenta development (GO:0001892)2.89950476
78regulation of interleukin-12 biosynthetic process (GO:0045075)2.89770044
79positive regulation of T cell mediated cytotoxicity (GO:0001916)2.89310305
80macrophage activation (GO:0042116)2.89111451
81leukocyte degranulation (GO:0043299)2.88605432
82* response to laminar fluid shear stress (GO:0034616)2.87860411
83negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.86903993
84positive regulation of antigen processing and presentation (GO:0002579)2.85838027
85regulation of dendritic cell antigen processing and presentation (GO:0002604)2.85619307
86regulation of chemokine secretion (GO:0090196)2.84646230
87lymphocyte homeostasis (GO:0002260)2.84526911
88regulation of gene silencing by RNA (GO:0060966)2.84310702
89regulation of posttranscriptional gene silencing (GO:0060147)2.84310702
90regulation of gene silencing by miRNA (GO:0060964)2.84310702
91positive regulation of tolerance induction (GO:0002645)2.83379561
92negative regulation of alpha-beta T cell activation (GO:0046636)2.82216720
93negative regulation of erythrocyte differentiation (GO:0045647)2.82090852
94leukocyte aggregation (GO:0070486)2.81795127
95production of molecular mediator involved in inflammatory response (GO:0002532)2.81647876
96negative regulation of glycoprotein biosynthetic process (GO:0010561)2.81219270
97regulation of myeloid leukocyte mediated immunity (GO:0002886)2.80481469
98antigen receptor-mediated signaling pathway (GO:0050851)2.79715664
99regulation of T-helper 2 cell differentiation (GO:0045628)2.79615804
100negative regulation of type 2 immune response (GO:0002829)2.78437904
101translational termination (GO:0006415)2.77537545
102negative regulation of bone resorption (GO:0045779)2.77199824
103leukocyte cell-cell adhesion (GO:0007159)2.76849879
104endothelial cell chemotaxis (GO:0035767)2.75495365
105trophectodermal cell differentiation (GO:0001829)2.75491479
106regulation of interferon-beta biosynthetic process (GO:0045357)2.75304167
107mature B cell differentiation (GO:0002335)2.71464451
108positive regulation by host of viral transcription (GO:0043923)2.68345341
109germinal center formation (GO:0002467)2.65583316
110immunoglobulin mediated immune response (GO:0016064)2.63922123
111ribosomal small subunit biogenesis (GO:0042274)2.63776829
112definitive hemopoiesis (GO:0060216)2.63121595
113T cell receptor signaling pathway (GO:0050852)2.62661291
114establishment of endothelial barrier (GO:0061028)2.62429981
115positive regulation of chemokine secretion (GO:0090197)2.58270560
116regulation of tolerance induction (GO:0002643)2.58195137
117cellular response to interleukin-15 (GO:0071350)2.56093239
118positive regulation of SMAD protein import into nucleus (GO:0060391)2.54345968
119negative regulation of phagocytosis (GO:0050765)2.53748241
120regulation of histone H3-K27 methylation (GO:0061085)2.53187379
121regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.51873015
122cellular response to zinc ion (GO:0071294)2.51640095
123regulation of SMAD protein import into nucleus (GO:0060390)2.50981015
124regulation of antigen processing and presentation (GO:0002577)2.50339018
125NIK/NF-kappaB signaling (GO:0038061)2.48086272
126leukocyte tethering or rolling (GO:0050901)2.44649828
127nodal signaling pathway (GO:0038092)2.43315290
128histone H4-K12 acetylation (GO:0043983)2.43313647
129regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.43176809
130positive regulation of Rap GTPase activity (GO:0032854)2.43121949
131lymph vessel development (GO:0001945)2.42577891
132microglial cell activation (GO:0001774)2.42409342
133determination of adult lifespan (GO:0008340)2.41415272
134vascular endothelial growth factor signaling pathway (GO:0038084)2.40528852
135positive regulation of isotype switching (GO:0045830)2.40347185
136positive regulation by symbiont of host defense response (GO:0052509)2.39686723
137modulation by symbiont of host defense response (GO:0052031)2.39686723
138modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.39686723
139modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.39686723
140positive regulation by organism of defense response of other organism involved in symbiotic interact2.39686723
141modulation by symbiont of host immune response (GO:0052553)2.39686723
142regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.39261485
143apoptotic process involved in morphogenesis (GO:0060561)2.38959063
144positive regulation of histone deacetylation (GO:0031065)2.38571090
145JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.38499165
146regulation of response to interferon-gamma (GO:0060330)2.38028653
147macrophage activation involved in immune response (GO:0002281)2.37607233
148angiogenesis involved in wound healing (GO:0060055)2.37333554
149T cell costimulation (GO:0031295)2.36723066
150natural killer cell differentiation (GO:0001779)2.36375655
151B cell mediated immunity (GO:0019724)2.36034879

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.59511872
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.55424281
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.43574721
4MYC_22102868_ChIP-Seq_BL_Human3.31305124
5* KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.10917479
6* KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.10917479
7* KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.10917479
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.98902538
9E2F7_22180533_ChIP-Seq_HELA_Human2.96833548
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.93291976
11VDR_21846776_ChIP-Seq_THP-1_Human2.54592905
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.37632845
13MAF_26560356_Chip-Seq_TH1_Human2.35936548
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.34578820
15* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.30754396
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.27633421
17TCF7_22412390_ChIP-Seq_EML_Mouse2.26388002
18* RUNX_20019798_ChIP-Seq_JUKART_Human2.19786228
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.17619300
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.17048078
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.16208872
22* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.09721655
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.07719073
24* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07272835
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.05044727
26* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.02551943
27* ELK3_25401928_ChIP-Seq_HUVEC_Human2.00995107
28MYB_26560356_Chip-Seq_TH2_Human2.00388290
29UTX_26944678_Chip-Seq_JUKART_Human2.00220876
30* IRF8_27001747_Chip-Seq_BMDM_Mouse1.99160804
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.96349794
32KDM2B_26808549_Chip-Seq_DND41_Human1.93608422
33* MYB_26560356_Chip-Seq_TH1_Human1.93223296
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.90822179
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.90025909
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.88722956
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.88688084
38* SCL_19346495_ChIP-Seq_HPC-7_Human1.88523220
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85292946
40* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.80172116
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77278897
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70215402
43VDR_24763502_ChIP-Seq_THP-1_Human1.70046349
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69350094
45* RUNX1_22412390_ChIP-Seq_EML_Mouse1.69335415
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68569357
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.67133089
48SPI1_23547873_ChIP-Seq_NB4_Human1.65587248
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.63866319
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61075285
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.60033653
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58683343
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.51046009
54MAF_26560356_Chip-Seq_TH2_Human1.50351720
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.50203583
56VDR_24787735_ChIP-Seq_THP-1_Human1.49854455
57* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.46580077
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.46320606
59* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45178913
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.40946493
61* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.37702015
62* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.33952009
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.33098485
64* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32678334
65NCOR1_26117541_ChIP-Seq_K562_Human1.31856930
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30212171
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30172295
68SPI1_23127762_ChIP-Seq_K562_Human1.29093186
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27988693
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.27487235
71GATA3_26560356_Chip-Seq_TH2_Human1.24323953
72MYC_19079543_ChIP-ChIP_MESCs_Mouse1.24274280
73* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23222744
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21392727
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19812885
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19121592
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17816040
78* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.16762996
79HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16598250
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15603061
81* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.14888622
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14844396
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14184479
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13949516
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13907278
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10004968
87CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08571705
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06725323
89IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06660028
90CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06453001
91BCL6_27268052_Chip-Seq_Bcells_Human1.06236536
92LXR_22292898_ChIP-Seq_THP-1_Human1.05793420
93* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04797241
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04391430
95SA1_27219007_Chip-Seq_ERYTHROID_Human1.03837056
96* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02949336
97NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01333350
98RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01114613
99* BCOR_27268052_Chip-Seq_Bcells_Human1.01007881
100ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00218638
101GATA3_27048872_Chip-Seq_THYMUS_Human1.00025289
102RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98481298
103* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98386360
104ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98275092
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98007762
106SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97537265
107* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96520822
108ELF1_20517297_ChIP-Seq_JURKAT_Human0.95889509
109GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95869490
110PU_27001747_Chip-Seq_BMDM_Mouse0.95799465
111* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94608180
112TP63_17297297_ChIP-ChIP_HaCaT_Human0.94018365
113CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93880103
114* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93840390
115CLOCK_20551151_ChIP-Seq_293T_Human0.92913302
116SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91989859
117RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91471507
118MYC_18555785_ChIP-Seq_MESCs_Mouse0.91165771
119PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90911449
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90699117
121GATA2_21666600_ChIP-Seq_HMVEC_Human0.90450886
122GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90275634
123PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90212160
124CIITA_25753668_ChIP-Seq_RAJI_Human0.90030574
125RACK7_27058665_Chip-Seq_MCF-7_Human0.89201192
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89162892
127* KDM2B_26808549_Chip-Seq_K562_Human0.88715432
128CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87849996
129FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.87297822
130GATA1_19941826_ChIP-Seq_K562_Human0.85503410
131LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.85353237
132FOXO3_23340844_ChIP-Seq_DLD1_Human0.84522090
133* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.82426085

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow3.22388277
2MP0003724_increased_susceptibility_to2.68512446
3MP0003303_peritoneal_inflammation2.64250668
4MP0003763_abnormal_thymus_physiology2.63522768
5MP0001835_abnormal_antigen_presentation2.57627653
6MP0000685_abnormal_immune_system2.56973938
7* MP0001800_abnormal_humoral_immune2.54251990
8MP0005671_abnormal_response_to2.42271953
9MP0001790_abnormal_immune_system2.37381291
10MP0005387_immune_system_phenotype2.37381291
11MP0003828_pulmonary_edema2.28091228
12* MP0002452_abnormal_antigen_presenting2.22762379
13MP0006082_CNS_inflammation2.16839667
14MP0005000_abnormal_immune_tolerance2.09429843
15* MP0002420_abnormal_adaptive_immunity2.08530503
16* MP0001819_abnormal_immune_cell2.05586371
17MP0002405_respiratory_system_inflammati2.05390815
18* MP0002723_abnormal_immune_serum2.04307299
19* MP0002398_abnormal_bone_marrow1.97278817
20MP0003436_decreased_susceptibility_to1.97096116
21MP0002166_altered_tumor_susceptibility1.92440473
22MP0005397_hematopoietic_system_phenotyp1.92287433
23MP0001545_abnormal_hematopoietic_system1.92287433
24MP0002396_abnormal_hematopoietic_system1.90683886
25MP0010368_abnormal_lymphatic_system1.88112953
26MP0009333_abnormal_splenocyte_physiolog1.85064083
27MP0000689_abnormal_spleen_morphology1.83108318
28MP0001873_stomach_inflammation1.81564215
29* MP0000716_abnormal_immune_system1.78521840
30MP0002722_abnormal_immune_system1.76364587
31MP0005025_abnormal_response_to1.72411711
32MP0002419_abnormal_innate_immunity1.69491842
33MP0002009_preneoplasia1.68883652
34MP0004808_abnormal_hematopoietic_stem1.68836571
35MP0004510_myositis1.68383751
36MP0003191_abnormal_cellular_cholesterol1.66097339
37MP0010155_abnormal_intestine_physiology1.63547017
38MP0000703_abnormal_thymus_morphology1.59166030
39MP0002148_abnormal_hypersensitivity_rea1.58106587
40MP0004381_abnormal_hair_follicle1.56271374
41MP0008057_abnormal_DNA_replication1.56026916
42MP0005464_abnormal_platelet_physiology1.55925263
43* MP0002429_abnormal_blood_cell1.55001863
44MP0008260_abnormal_autophagy1.53553018
45MP0005167_abnormal_blood-brain_barrier1.52049363
46MP0010352_gastrointestinal_tract_polyps1.50930062
47MP0002006_tumorigenesis1.48438531
48MP0001879_abnormal_lymphatic_vessel1.45935260
49MP0003566_abnormal_cell_adhesion1.44548037
50MP0005076_abnormal_cell_differentiation1.43379625
51MP0003448_altered_tumor_morphology1.43008388
52MP0003172_abnormal_lysosome_physiology1.41785863
53MP0009785_altered_susceptibility_to1.39878693
54MP0003300_gastrointestinal_ulcer1.38085595
55MP0005023_abnormal_wound_healing1.37789911
56MP0004947_skin_inflammation1.37259979
57MP0000490_abnormal_crypts_of1.34446501
58MP0000465_gastrointestinal_hemorrhage1.34154066
59MP0001845_abnormal_inflammatory_respons1.29914010
60MP0001851_eye_inflammation1.27946270
61MP0001853_heart_inflammation1.23615201
62MP0003453_abnormal_keratinocyte_physiol1.22862369
63MP0002933_joint_inflammation1.20954642
64MP0001533_abnormal_skeleton_physiology1.20856291
65MP0000858_altered_metastatic_potential1.14030267
66MP0008007_abnormal_cellular_replicative1.13424662
67MP0002277_abnormal_respiratory_mucosa1.12317320
68MP0002254_reproductive_system_inflammat1.08411553
69MP0001986_abnormal_taste_sensitivity1.06384847
70MP0004130_abnormal_muscle_cell1.04378208
71MP0009764_decreased_sensitivity_to1.03144520
72MP0008961_abnormal_basal_metabolism1.01590468
73MP0008995_early_reproductive_senescence1.01285447
74MP0000249_abnormal_blood_vessel0.99838992
75MP0000343_altered_response_to0.99745027
76MP0003183_abnormal_peptide_metabolism0.97946957
77MP0003077_abnormal_cell_cycle0.97620715
78MP0005451_abnormal_body_composition0.96893155
79MP0005164_abnormal_response_to0.94590406
80MP0002138_abnormal_hepatobiliary_system0.94394735
81MP0002132_abnormal_respiratory_system0.94162776
82MP0003866_abnormal_defecation0.93257365
83MP0001663_abnormal_digestive_system0.92951906
84MP0002925_abnormal_cardiovascular_devel0.92545908
85MP0002019_abnormal_tumor_incidence0.91879644
86* MP0002086_abnormal_extraembryonic_tissu0.91605877
87MP0002928_abnormal_bile_duct0.90700092
88MP0004883_abnormal_blood_vessel0.89328751
89MP0002998_abnormal_bone_remodeling0.88799135
90MP0003705_abnormal_hypodermis_morpholog0.86869557
91* MP0000767_abnormal_smooth_muscle0.86242930
92MP0010094_abnormal_chromosome_stability0.85872241
93MP0003091_abnormal_cell_migration0.85768107
94MP0005166_decreased_susceptibility_to0.85410627
95MP0008004_abnormal_stomach_pH0.83483839
96MP0000350_abnormal_cell_proliferation0.83094024
97MP0001915_intracranial_hemorrhage0.82180838
98MP0005670_abnormal_white_adipose0.81777142
99MP0003943_abnormal_hepatobiliary_system0.81518192
100MP0005058_abnormal_lysosome_morphology0.79786048
101MP0008469_abnormal_protein_level0.79491547
102MP0004957_abnormal_blastocyst_morpholog0.78997043
103MP0005390_skeleton_phenotype0.77369591
104MP0003690_abnormal_glial_cell0.77233273
105MP0003693_abnormal_embryo_hatching0.75945530
106MP0004185_abnormal_adipocyte_glucose0.75697521
107MP0003045_fibrosis0.75372348
108* MP0003279_aneurysm0.75300899
109MP0003786_premature_aging0.74502383
110MP0003136_yellow_coat_color0.74372206
111MP0005310_abnormal_salivary_gland0.72949666
112MP0003075_altered_response_to0.72875633
113MP0009763_increased_sensitivity_to0.72078979
114MP0005075_abnormal_melanosome_morpholog0.68477312
115MP0006054_spinal_hemorrhage0.68356202
116* MP0001614_abnormal_blood_vessel0.67518385
117* MP0002088_abnormal_embryonic_growth/wei0.66747738
118MP0003795_abnormal_bone_structure0.65709254
119MP0004484_altered_response_of0.60953518
120MP0008874_decreased_physiological_sensi0.57263884
121MP0009840_abnormal_foam_cell0.55802398
122MP0002133_abnormal_respiratory_system0.54476338
123MP0005388_respiratory_system_phenotype0.54476338
124MP0001958_emphysema0.53949289
125MP0005381_digestive/alimentary_phenotyp0.53908741
126MP0009765_abnormal_xenobiotic_induced0.51160525
127MP0009115_abnormal_fat_cell0.49427092
128MP0002693_abnormal_pancreas_physiology0.45759495
129MP0000604_amyloidosis0.44638717

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)4.67387869
2Spontaneous hematomas (HP:0007420)4.18332659
3Pustule (HP:0200039)4.16830279
4Systemic lupus erythematosus (HP:0002725)4.09870462
5Optic neuritis (HP:0100653)4.07682560
6Retrobulbar optic neuritis (HP:0100654)4.07682560
7Gastrointestinal infarctions (HP:0005244)3.93920824
8Abnormality of the nasal mucosa (HP:0000433)3.93481421
9Hematochezia (HP:0002573)3.68869898
10Recurrent abscess formation (HP:0002722)3.61934037
11Cerebral aneurysm (HP:0004944)3.55565950
12Nasal polyposis (HP:0100582)3.51239979
13Encephalitis (HP:0002383)3.47951381
14Eczematoid dermatitis (HP:0000976)3.43042513
15Glomerulonephritis (HP:0000099)3.30074324
16Colitis (HP:0002583)3.28802409
17Recurrent bronchitis (HP:0002837)3.21540131
18IgM deficiency (HP:0002850)3.20112221
19Inflammation of the large intestine (HP:0002037)3.17492292
20Elevated erythrocyte sedimentation rate (HP:0003565)3.12330091
21Recurrent fungal infections (HP:0002841)3.10376689
22Hypochromic microcytic anemia (HP:0004840)3.08913219
23Cellulitis (HP:0100658)3.03353472
24Gingivitis (HP:0000230)3.02163957
25Gastrointestinal inflammation (HP:0004386)3.00054471
26Keratoconjunctivitis sicca (HP:0001097)2.99902634
27Pulmonary infiltrates (HP:0002113)2.94859747
28Granulocytopenia (HP:0001913)2.88556523
29Urticaria (HP:0001025)2.85172947
30T lymphocytopenia (HP:0005403)2.84489348
31Recurrent viral infections (HP:0004429)2.83754258
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.80596667
33Keratoconjunctivitis (HP:0001096)2.76755320
34Abnormality of T cell number (HP:0011839)2.75452628
35Prolonged bleeding time (HP:0003010)2.71181115
36Recurrent bacterial skin infections (HP:0005406)2.68710069
37Papilledema (HP:0001085)2.67613194
38Agammaglobulinemia (HP:0004432)2.65051628
39Myositis (HP:0100614)2.64839335
40Episodic fever (HP:0001954)2.62763072
41Aortic aneurysm (HP:0004942)2.62586244
42Intestinal fistula (HP:0100819)2.56394592
43Abnormality of T cells (HP:0002843)2.55979449
44Chronic otitis media (HP:0000389)2.55131648
45Stomatitis (HP:0010280)2.48764353
46Pulmonary embolism (HP:0002204)2.48715732
47Gingival bleeding (HP:0000225)2.47415083
48Emphysema (HP:0002097)2.45447189
49Autoimmune hemolytic anemia (HP:0001890)2.44576538
50Abnormality of the fingertips (HP:0001211)2.40990976
51Osteomyelitis (HP:0002754)2.38979817
52Panhypogammaglobulinemia (HP:0003139)2.36460650
53Meningitis (HP:0001287)2.35943595
54Microcytic anemia (HP:0001935)2.33924790
55Basal cell carcinoma (HP:0002671)2.30932994
56Hypergammaglobulinemia (HP:0010702)2.30406758
57Sepsis (HP:0100806)2.30357295
58Slow saccadic eye movements (HP:0000514)2.29447587
59Gastrointestinal stroma tumor (HP:0100723)2.27655794
60Reticulocytopenia (HP:0001896)2.27092768
61Anorexia (HP:0002039)2.26979773
62Urethral obstruction (HP:0000796)2.25682239
63Rectal fistula (HP:0100590)2.24289460
64Rectovaginal fistula (HP:0000143)2.24289460
65Polycythemia (HP:0001901)2.22401198
66Spondylolisthesis (HP:0003302)2.21573947
67Mediastinal lymphadenopathy (HP:0100721)2.20930114
68Petechiae (HP:0000967)2.18985688
69Obstructive lung disease (HP:0006536)2.16861292
70Chronic obstructive pulmonary disease (HP:0006510)2.16861292
71Arterial tortuosity (HP:0005116)2.15297868
72Nephritis (HP:0000123)2.15032596
73Recurrent cutaneous fungal infections (HP:0011370)2.15002615
74Chronic mucocutaneous candidiasis (HP:0002728)2.15002615
75Severe combined immunodeficiency (HP:0004430)2.14806344
76Lymphopenia (HP:0001888)2.12223062
77Abnormality of the pleura (HP:0002103)2.10777477
78Abnormality of cells of the lymphoid lineage (HP:0012140)2.10230163
79Abnormality of T cell physiology (HP:0011840)2.09681199
80Leukocytosis (HP:0001974)2.06219551
81Peritonitis (HP:0002586)2.06185172
82Autoimmune thrombocytopenia (HP:0001973)2.06011735
83Papilloma (HP:0012740)2.04444922
84Verrucae (HP:0200043)2.04444922
85Dysostosis multiplex (HP:0000943)2.04313429
86Obstructive sleep apnea (HP:0002870)2.03897988
87Viral hepatitis (HP:0006562)2.02477560
88Purpura (HP:0000979)2.02335890
89Vasculitis (HP:0002633)2.01764762
90Stomach cancer (HP:0012126)2.01622684
91Cheilitis (HP:0100825)2.01320179
92Restrictive lung disease (HP:0002091)2.00507247
93Increased IgE level (HP:0003212)1.99539610
94Epistaxis (HP:0000421)1.99179662
95Abnormality of the peritoneum (HP:0002585)1.96669939
96Vascular tortuosity (HP:0004948)1.96421202
97Glomerulopathy (HP:0100820)1.94611678
98Abnormal platelet volume (HP:0011876)1.93608139
99Recurrent skin infections (HP:0001581)1.93137482
100Amyloidosis (HP:0011034)1.92361311
101Vaginal fistula (HP:0004320)1.91655940
102Agnosia (HP:0010524)1.91483432
103Abnormality of glycolipid metabolism (HP:0010969)1.91105379
104Abnormality of liposaccharide metabolism (HP:0010968)1.91105379
105Abnormality of glycosphingolipid metabolism (HP:0004343)1.91105379
106Rib fusion (HP:0000902)1.90709457
107Eosinophilia (HP:0001880)1.88317448
108Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.88278537
109Orchitis (HP:0100796)1.87081842
110Recurrent sinusitis (HP:0011108)1.86985249
111Abnormality of complement system (HP:0005339)1.86574105
112IgA deficiency (HP:0002720)1.86201282
113Polygenic inheritance (HP:0010982)1.85850539
114Gangrene (HP:0100758)1.85279952
115Increased IgM level (HP:0003496)1.85030071
116Increased serum ferritin (HP:0003281)1.84595991
117Lymphoma (HP:0002665)1.84477069
118Thrombocytosis (HP:0001894)1.84142671
119Complement deficiency (HP:0004431)1.82735375
120Combined immunodeficiency (HP:0005387)1.82307237
121Hemoptysis (HP:0002105)1.80984778
122Disproportionate tall stature (HP:0001519)1.80762806
123Premature loss of primary teeth (HP:0006323)1.80624222
124Aortic dissection (HP:0002647)1.80507722
125Joint swelling (HP:0001386)1.79283729
126Mitral valve prolapse (HP:0001634)1.78903031
127Joint stiffness (HP:0001387)1.78385309
128Alveolar cell carcinoma (HP:0006519)1.78290640
129Bronchitis (HP:0012387)1.77113502
130Myocardial infarction (HP:0001658)1.76755259
131Chest pain (HP:0100749)1.76040394
132Skin ulcer (HP:0200042)1.75866917
133Bicuspid aortic valve (HP:0001647)1.75857906
134IgG deficiency (HP:0004315)1.74079810
135Adactyly (HP:0009776)1.72301583
136Asplenia (HP:0001746)1.72165155
137Hypochromic anemia (HP:0001931)1.71353594
138Abnormality of eosinophils (HP:0001879)1.70604876
139Arterial thrombosis (HP:0004420)1.70394461
140Interstitial pulmonary disease (HP:0006530)1.70025900
141Distal lower limb muscle weakness (HP:0009053)1.70020448
142Recurrent gram-negative bacterial infections (HP:0005420)1.68797697
143Chronic diarrhea (HP:0002028)1.68031771
144Leukopenia (HP:0001882)1.67794746

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.38505192
2MAP4K14.26782963
3RIPK43.83906445
4MAPK153.66970003
5PRPF4B3.17302462
6STK103.09683176
7CDK122.53642753
8BLK2.40556659
9TNK22.31331103
10GRK62.30186518
11MAP3K102.16897213
12CSK2.10134725
13TYK22.03898348
14KDR2.01964054
15TIE11.87753428
16SIK31.79863659
17ITK1.79682212
18TXK1.77217203
19MAP3K141.75071538
20TAOK31.68500468
21ZAP701.59096826
22IRAK31.57631455
23TSSK61.55613332
24CSF1R1.55580075
25NLK1.52152733
26ERN11.49528497
27PIM11.48227466
28JAK31.48187099
29PRKD21.44468782
30IRAK41.42767449
31IKBKB1.35965781
32GRK71.34133998
33TAOK11.33137957
34BTK1.31206550
35MAP2K31.24766153
36MARK31.24487124
37CLK11.22354931
38MARK21.21899427
39IKBKE1.20521743
40TBK11.19828185
41EEF2K1.18182251
42MAPK71.15937426
43MAP2K21.14373160
44HCK1.13286500
45SIK11.12474313
46JAK11.10723998
47LCK1.09244017
48TEC1.08872790
49LRRK21.08301428
50PASK1.05087918
51FGFR41.02273096
52MAP3K71.02017911
53EPHB11.00230952
54MAP3K11.00031668
55RPS6KA40.98347423
56MST40.96844449
57MATK0.94891922
58FGR0.93193636
59CAMKK10.91940241
60RPS6KB20.90489325
61PAK40.90466844
62EPHA20.89469106
63CDK40.85810020
64PDK10.85240483
65FGFR30.83056452
66MAPK120.81931639
67CDC42BPA0.80906944
68TGFBR10.79522771
69SMG10.78542330
70NME20.78367893
71CDK60.77439677
72IRAK10.76986267
73MAP3K30.76889296
74PKN20.75460716
75CHUK0.75196983
76PRKCQ0.72700354
77BMPR20.72684543
78YES10.72302969
79CAMK1D0.71567232
80SYK0.70951457
81GRK10.68958546
82LYN0.68101335
83CAMKK20.67784038
84RPS6KA60.67605302
85MELK0.67377028
86TYRO30.67302847
87JAK20.66400128
88RPS6KL10.66242627
89RPS6KC10.66242627
90MAPKAPK30.66016488
91TTN0.64714025
92DYRK1B0.64393732
93IRAK20.64224752
94TAOK20.63381986
95ALK0.62605050
96BMX0.62284802
97KSR20.62272557
98KIT0.60743313
99CDK70.60211631
100PTK60.60024405
101PDPK10.59717802
102MAP3K130.59129922
103HIPK20.59047170
104CDK90.57686230
105FYN0.57432877
106VRK10.56985142
107GSK3A0.55879440
108ICK0.55164518
109MAP3K110.54422597
110PDK20.54214948
111SIK20.52650518
112MAPKAPK20.52389788
113PRKG20.51957780
114DYRK30.51305906
115NEK20.51293303
116SGK30.50226032
117PTK2B0.50154715
118PRKD10.50053078
119STK40.50035947
120FES0.48392467
121TESK20.46930402
122TRIB30.46802347
123RIPK10.45833678
124STK380.45669086
125MAPK40.43672132
126PIK3CG0.43176893
127STK110.42991351
128BRD40.42880114
129INSR0.42631870
130MAP3K60.41866321
131RET0.39921707
132ACVR1B0.38091146
133PRKCH0.37050324
134CAMK40.35882273
135EPHA30.32923706
136SGK20.32843079
137MAPK110.32506578

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.02415127
2B cell receptor signaling pathway_Homo sapiens_hsa046622.58863614
3Staphylococcus aureus infection_Homo sapiens_hsa051502.37957334
4Autoimmune thyroid disease_Homo sapiens_hsa053202.28814960
5Osteoclast differentiation_Homo sapiens_hsa043802.28230771
6Leishmaniasis_Homo sapiens_hsa051402.11759097
7Antigen processing and presentation_Homo sapiens_hsa046122.09388413
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.04305953
9Other glycan degradation_Homo sapiens_hsa005111.91157429
10T cell receptor signaling pathway_Homo sapiens_hsa046601.85570531
11Measles_Homo sapiens_hsa051621.82772384
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.79356799
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78416115
14Ribosome_Homo sapiens_hsa030101.74312049
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.74212724
16Hematopoietic cell lineage_Homo sapiens_hsa046401.72917504
17Type I diabetes mellitus_Homo sapiens_hsa049401.68834901
18Leukocyte transendothelial migration_Homo sapiens_hsa046701.63599387
19Acute myeloid leukemia_Homo sapiens_hsa052211.55823886
20Notch signaling pathway_Homo sapiens_hsa043301.51662866
21Herpes simplex infection_Homo sapiens_hsa051681.51159142
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.50530237
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.46378603
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45308468
25Transcriptional misregulation in cancer_Homo sapiens_hsa052021.44503751
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39580833
27Toxoplasmosis_Homo sapiens_hsa051451.38302708
28Adherens junction_Homo sapiens_hsa045201.34530230
29Pertussis_Homo sapiens_hsa051331.33753861
30Non-small cell lung cancer_Homo sapiens_hsa052231.28183362
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.25562762
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23153221
33Colorectal cancer_Homo sapiens_hsa052101.21801178
34Asthma_Homo sapiens_hsa053101.21386901
35Chronic myeloid leukemia_Homo sapiens_hsa052201.20939000
36Platelet activation_Homo sapiens_hsa046111.18519799
37Apoptosis_Homo sapiens_hsa042101.18449227
38Chemokine signaling pathway_Homo sapiens_hsa040621.18326556
39Legionellosis_Homo sapiens_hsa051341.16948093
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16521100
41Hepatitis B_Homo sapiens_hsa051611.14806184
42Shigellosis_Homo sapiens_hsa051311.14481318
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14418887
44HTLV-I infection_Homo sapiens_hsa051661.12887898
45TNF signaling pathway_Homo sapiens_hsa046681.12578427
46Viral myocarditis_Homo sapiens_hsa054161.09694959
47Influenza A_Homo sapiens_hsa051641.08291794
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07932462
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06947725
50Mismatch repair_Homo sapiens_hsa034301.06433029
51Malaria_Homo sapiens_hsa051441.03852606
52Spliceosome_Homo sapiens_hsa030401.03339898
53African trypanosomiasis_Homo sapiens_hsa051431.02321505
54Graft-versus-host disease_Homo sapiens_hsa053321.00907908
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99603088
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99237884
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98489703
58Small cell lung cancer_Homo sapiens_hsa052220.97633085
59Pancreatic cancer_Homo sapiens_hsa052120.97209906
60Epstein-Barr virus infection_Homo sapiens_hsa051690.96910460
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96548893
62Tuberculosis_Homo sapiens_hsa051520.93975024
63VEGF signaling pathway_Homo sapiens_hsa043700.89111206
64Base excision repair_Homo sapiens_hsa034100.87841261
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86615365
66Salmonella infection_Homo sapiens_hsa051320.84432452
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.83269586
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82600636
69Rheumatoid arthritis_Homo sapiens_hsa053230.82454612
70p53 signaling pathway_Homo sapiens_hsa041150.81996911
71Pathways in cancer_Homo sapiens_hsa052000.81185333
72DNA replication_Homo sapiens_hsa030300.80636288
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80106554
74Phagosome_Homo sapiens_hsa041450.79686568
75Focal adhesion_Homo sapiens_hsa045100.78240517
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78083178
77TGF-beta signaling pathway_Homo sapiens_hsa043500.76934294
78Rap1 signaling pathway_Homo sapiens_hsa040150.76610202
79Viral carcinogenesis_Homo sapiens_hsa052030.76564913
80Endometrial cancer_Homo sapiens_hsa052130.76372077
81MAPK signaling pathway_Homo sapiens_hsa040100.75246843
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72740435
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71846368
84GnRH signaling pathway_Homo sapiens_hsa049120.69518650
85Renal cell carcinoma_Homo sapiens_hsa052110.69393981
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.68795195
87Prostate cancer_Homo sapiens_hsa052150.68072584
88HIF-1 signaling pathway_Homo sapiens_hsa040660.67586106
89MicroRNAs in cancer_Homo sapiens_hsa052060.67274296
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64766334
91Inositol phosphate metabolism_Homo sapiens_hsa005620.63839795
92Prion diseases_Homo sapiens_hsa050200.63761451
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63264521
94mTOR signaling pathway_Homo sapiens_hsa041500.63029446
95Proteoglycans in cancer_Homo sapiens_hsa052050.62435774
96Lysosome_Homo sapiens_hsa041420.61384114
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61154656
98Hepatitis C_Homo sapiens_hsa051600.61110643
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59773832
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.59751987
101Fanconi anemia pathway_Homo sapiens_hsa034600.59333483
102Endocytosis_Homo sapiens_hsa041440.59169193
103* FoxO signaling pathway_Homo sapiens_hsa040680.56552209
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56378544
105Dorso-ventral axis formation_Homo sapiens_hsa043200.55962631
106Allograft rejection_Homo sapiens_hsa053300.54141285
107ErbB signaling pathway_Homo sapiens_hsa040120.53787941
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.53231879
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53161487
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52211499
111Choline metabolism in cancer_Homo sapiens_hsa052310.51971794
112Amoebiasis_Homo sapiens_hsa051460.50697536
113Complement and coagulation cascades_Homo sapiens_hsa046100.49781955
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49609841
115Thyroid cancer_Homo sapiens_hsa052160.48815417
116RNA transport_Homo sapiens_hsa030130.48039384
117Homologous recombination_Homo sapiens_hsa034400.47578251
118Ras signaling pathway_Homo sapiens_hsa040140.47376365
119Estrogen signaling pathway_Homo sapiens_hsa049150.47031562
120Prolactin signaling pathway_Homo sapiens_hsa049170.46325387
121Regulation of autophagy_Homo sapiens_hsa041400.44005605
122Long-term potentiation_Homo sapiens_hsa047200.43695226
123Insulin resistance_Homo sapiens_hsa049310.43526579
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.41889138
125Hippo signaling pathway_Homo sapiens_hsa043900.41293562
126Type II diabetes mellitus_Homo sapiens_hsa049300.41184233
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39590539
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36760623

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