KLF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.69860706
2negative regulation of cell killing (GO:0031342)4.69860706
3desmosome organization (GO:0002934)4.56723452
4neutrophil activation involved in immune response (GO:0002283)3.79533800
5hemidesmosome assembly (GO:0031581)3.75715666
6regulation of B cell receptor signaling pathway (GO:0050855)3.65336066
7negative regulation of erythrocyte differentiation (GO:0045647)3.59721865
8detection of molecule of bacterial origin (GO:0032490)3.46464687
9histone H3-K36 demethylation (GO:0070544)3.42918064
10leukocyte aggregation (GO:0070486)3.37539718
11positive regulation of granulocyte differentiation (GO:0030854)3.35380845
12response to interleukin-15 (GO:0070672)3.34769531
13macrophage activation involved in immune response (GO:0002281)3.28908478
14negative regulation of lymphocyte mediated immunity (GO:0002707)3.19432999
15regulation of water loss via skin (GO:0033561)3.17964709
16establishment of skin barrier (GO:0061436)3.14990251
17embryonic process involved in female pregnancy (GO:0060136)3.14402218
18tolerance induction (GO:0002507)3.13443558
19response to peptidoglycan (GO:0032494)3.09333404
20neutrophil activation (GO:0042119)3.07839252
21detection of biotic stimulus (GO:0009595)3.06911173
22response to laminar fluid shear stress (GO:0034616)3.05023324
23regulation of chemokine secretion (GO:0090196)3.01957555
24bundle of His cell to Purkinje myocyte communication (GO:0086069)3.00920765
25positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.99342504
26hepatocyte apoptotic process (GO:0097284)2.95905340
27regulation of tolerance induction (GO:0002643)2.94828726
28definitive hemopoiesis (GO:0060216)2.94047121
29negative regulation of T cell mediated immunity (GO:0002710)2.93436945
30microglial cell activation (GO:0001774)2.84554062
31granulocyte activation (GO:0036230)2.80060522
32negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.78740837
33negative regulation of leukocyte mediated immunity (GO:0002704)2.75976430
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.75894023
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.75894023
36cellular response to interleukin-15 (GO:0071350)2.75317065
37response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.74413286
38response to host (GO:0075136)2.74413286
39response to host defenses (GO:0052200)2.74413286
40negative regulation of interleukin-12 production (GO:0032695)2.72826313
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.72450800
42response to host immune response (GO:0052572)2.72450800
43macrophage activation (GO:0042116)2.72182459
44skin morphogenesis (GO:0043589)2.70536253
45negative regulation of glycoprotein biosynthetic process (GO:0010561)2.68381542
46negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.67309482
47negative regulation of T-helper cell differentiation (GO:0045623)2.67309482
48leukocyte migration involved in inflammatory response (GO:0002523)2.66409788
49B cell receptor signaling pathway (GO:0050853)2.64041647
50activated T cell proliferation (GO:0050798)2.63012191
51negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.61565428
52oxygen transport (GO:0015671)2.60564110
53regulation of alpha-beta T cell proliferation (GO:0046640)2.59474292
54antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.57899639
55regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.57857936
56regulation of regulatory T cell differentiation (GO:0045589)2.56789310
57megakaryocyte development (GO:0035855)2.56619715
58hemoglobin metabolic process (GO:0020027)2.55442483
59myeloid cell development (GO:0061515)2.53108281
60negative regulation of stress fiber assembly (GO:0051497)2.51348979
61myeloid cell activation involved in immune response (GO:0002275)2.51300479
62T cell migration (GO:0072678)2.50293642
63surfactant homeostasis (GO:0043129)2.49511976
64keratinocyte proliferation (GO:0043616)2.49504260
65establishment of endothelial barrier (GO:0061028)2.48122231
66positive regulation of B cell differentiation (GO:0045579)2.47944692
67antigen processing and presentation of endogenous antigen (GO:0019883)2.47624940
68positive thymic T cell selection (GO:0045059)2.47082122
69regulation of interferon-beta biosynthetic process (GO:0045357)2.46206063
70regulation of necroptotic process (GO:0060544)2.45542881
71regulation of granulocyte differentiation (GO:0030852)2.44041099
72regulation of B cell differentiation (GO:0045577)2.42824504
73neutrophil mediated immunity (GO:0002446)2.42627919
74lymph vessel development (GO:0001945)2.42373956
75phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.42282611
76phospholipid efflux (GO:0033700)2.41841171
77erythrocyte maturation (GO:0043249)2.41319231
78endodermal cell differentiation (GO:0035987)2.41240176
79protoporphyrinogen IX metabolic process (GO:0046501)2.41027293
80positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.40476392
81regulation of mast cell degranulation (GO:0043304)2.40385697
82antigen processing and presentation via MHC class Ib (GO:0002475)2.40329191
83detection of other organism (GO:0098543)2.40285437
84erythrocyte development (GO:0048821)2.40014617
85negative regulation of adaptive immune response (GO:0002820)2.39984451
86positive regulation of gamma-delta T cell activation (GO:0046645)2.39528920
87keratinocyte differentiation (GO:0030216)2.39473750
88positive regulation of cellular amide metabolic process (GO:0034250)2.39070064
89negative regulation of interleukin-6 production (GO:0032715)2.38935768
90dendritic cell migration (GO:0036336)2.37886807
91regulation of T cell tolerance induction (GO:0002664)2.37196709
92keratinization (GO:0031424)2.36962449
93gas transport (GO:0015669)2.36203915
94positive regulation of cholesterol efflux (GO:0010875)2.35191163
95radial glial cell differentiation (GO:0060019)2.33838403
96cell adhesion mediated by integrin (GO:0033627)2.33483084
97positive regulation of interleukin-8 secretion (GO:2000484)2.33042915
98detection of bacterium (GO:0016045)2.32690302
99cytoplasmic mRNA processing body assembly (GO:0033962)2.32413698
100regulation of myeloid leukocyte mediated immunity (GO:0002886)2.30689268
101regulation of leukocyte degranulation (GO:0043300)2.30253796
102hypotonic response (GO:0006971)2.30231221
103respiratory burst (GO:0045730)2.30068020
104regulation of interleukin-8 secretion (GO:2000482)2.25616280
105vascular endothelial growth factor signaling pathway (GO:0038084)2.25524641
106positive regulation of p38MAPK cascade (GO:1900745)2.25145153
107mesodermal cell differentiation (GO:0048333)2.25108554
108positive regulation of chemokine secretion (GO:0090197)2.25092871
109thymic T cell selection (GO:0045061)2.24951360
110regulation of cytokine secretion involved in immune response (GO:0002739)2.22792896
111negative regulation of fatty acid transport (GO:2000192)2.22546301
112regulation of gamma-delta T cell differentiation (GO:0045586)2.22247265
113atrioventricular valve morphogenesis (GO:0003181)2.19887942
114positive regulation of sterol transport (GO:0032373)2.18034101
115positive regulation of cholesterol transport (GO:0032376)2.18034101
116heterotypic cell-cell adhesion (GO:0034113)2.17726472
117regulation of phospholipase A2 activity (GO:0032429)2.17705687
118regulation of gamma-delta T cell activation (GO:0046643)2.16122169
119positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.15160764
120cellular extravasation (GO:0045123)2.14427932
121positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.13749881
122positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.13710129
123cell-substrate junction assembly (GO:0007044)2.12936841
124apoptotic cell clearance (GO:0043277)2.12715466
125gland morphogenesis (GO:0022612)2.11605491
126negative T cell selection (GO:0043383)2.09430381
127multicellular organismal water homeostasis (GO:0050891)2.08024245
128positive T cell selection (GO:0043368)2.07558630
129regulation of superoxide anion generation (GO:0032928)2.06209952
130positive regulation of tolerance induction (GO:0002645)2.06149310
131positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.06118114
132I-kappaB phosphorylation (GO:0007252)2.05846146
133peptide cross-linking (GO:0018149)2.05548675
134positive regulation of endothelial cell apoptotic process (GO:2000353)2.05483988
135regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.05125999
136regulation of interleukin-12 biosynthetic process (GO:0045075)2.04187960
137regulation of integrin activation (GO:0033623)2.04141862
138epithelial cell-cell adhesion (GO:0090136)2.03302332
139negative regulation of interleukin-8 production (GO:0032717)2.03232164
140protoporphyrinogen IX biosynthetic process (GO:0006782)2.03035483
141positive regulation of interferon-alpha production (GO:0032727)2.02586510
142negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.02131000
143germ cell migration (GO:0008354)2.02100958
144detection of external biotic stimulus (GO:0098581)2.02092788
145negative regulation of protein autophosphorylation (GO:0031953)2.01830903
146modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.01139004
147positive regulation by organism of defense response of other organism involved in symbiotic interact2.01139004
148modulation by symbiont of host immune response (GO:0052553)2.01139004
149positive regulation by symbiont of host defense response (GO:0052509)2.01139004
150modulation by symbiont of host defense response (GO:0052031)2.01139004
151modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.01139004
152positive regulation of Rho protein signal transduction (GO:0035025)2.00748325
153negative regulation of viral entry into host cell (GO:0046597)2.00483803
154response to muramyl dipeptide (GO:0032495)1.99391966
155hormone catabolic process (GO:0042447)1.98922435
156T cell selection (GO:0045058)1.98832074
157endothelial cell morphogenesis (GO:0001886)1.98776731
158regulation of cholesterol homeostasis (GO:2000188)1.98643707
159positive regulation of histone deacetylation (GO:0031065)1.97599002
160response to fluid shear stress (GO:0034405)1.97213063
161regulation of extracellular matrix disassembly (GO:0010715)1.97058734
162interferon-gamma production (GO:0032609)1.96969451
163negative thymic T cell selection (GO:0045060)1.95407699
164leukocyte cell-cell adhesion (GO:0007159)1.95160366
165protein localization to endosome (GO:0036010)1.95072423
166epidermal cell differentiation (GO:0009913)1.94398564
167plasma lipoprotein particle assembly (GO:0034377)1.93718798
168blood vessel endothelial cell migration (GO:0043534)1.93138411

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.37824510
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.94615820
3* FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.49640668
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.97258042
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.95927179
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.78096312
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.49108020
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.42681148
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.35378612
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.22741944
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.06391634
12* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.05863325
13* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.03908795
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.98000586
15* RXR_22158963_ChIP-Seq_LIVER_Mouse1.97031182
16RARG_19884340_ChIP-ChIP_MEFs_Mouse1.96795701
17* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.95650941
18* FOXO3_23340844_ChIP-Seq_DLD1_Human1.94189117
19* LXR_22158963_ChIP-Seq_LIVER_Mouse1.91503257
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89040352
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.84791676
22SPI1_23127762_ChIP-Seq_K562_Human1.81629167
23RUNX_20019798_ChIP-Seq_JUKART_Human1.80139426
24CLOCK_20551151_ChIP-Seq_293T_Human1.77824402
25CDX2_20551321_ChIP-Seq_CACO-2_Human1.76677519
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.75455392
27* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.75372673
28* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.75372673
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73145849
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.72007781
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.67619084
32SOX9_24532713_ChIP-Seq_HFSC_Mouse1.65471283
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.65447712
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.64323414
35GATA2_21666600_ChIP-Seq_HMVEC_Human1.62902562
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.62639408
37* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.56163029
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.55302003
39GATA1_19941827_ChIP-Seq_MEL_Mouse1.52916206
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.52897700
41SOX2_20726797_ChIP-Seq_SW620_Human1.52796554
42SPI1_23547873_ChIP-Seq_NB4_Human1.51729565
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51026459
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.50431906
45* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49705725
46* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48964646
47GATA1_19941826_ChIP-Seq_K562_Human1.48386469
48P63_26484246_Chip-Seq_KERATINOCYTES_Human1.48146766
49TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48015977
50GATA1_22025678_ChIP-Seq_K562_Human1.47122426
51* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.45661119
52GATA3_27048872_Chip-Seq_THYMUS_Human1.44578266
53* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43798893
54GATA4_25053715_ChIP-Seq_YYC3_Human1.42926040
55GATA6_25053715_ChIP-Seq_YYC3_Human1.40388146
56MAF_26560356_Chip-Seq_TH1_Human1.39040053
57* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38353922
58MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.37668935
59IRF8_21731497_ChIP-ChIP_J774_Mouse1.37236825
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.36883648
61KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36536725
62SCL_19346495_ChIP-Seq_HPC-7_Human1.36081689
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35093699
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34381581
65PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33266903
66FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.31462570
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31277940
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30573193
69* TCF7_22412390_ChIP-Seq_EML_Mouse1.30217654
70* GATA2_19941826_ChIP-Seq_K562_Human1.28919866
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28299614
72CJUN_26792858_Chip-Seq_BT549_Human1.26567047
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25528740
74MYB_26560356_Chip-Seq_TH2_Human1.25005359
75PU_27001747_Chip-Seq_BMDM_Mouse1.24083725
76ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22559030
77VDR_21846776_ChIP-Seq_THP-1_Human1.21710879
78PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20183511
79* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18673169
80* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17416318
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16174814
82GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15507006
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14263895
84RACK7_27058665_Chip-Seq_MCF-7_Human1.14174169
85PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14138842
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13934937
87KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12969103
88MYB_26560356_Chip-Seq_TH1_Human1.12808331
89* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11862155
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10232021
91SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09221439
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08877546
93KDM2B_26808549_Chip-Seq_JURKAT_Human1.05818497
94UTX_26944678_Chip-Seq_JUKART_Human1.05535122
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05366602
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05120076
97* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03975462
98* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03665668
99GATA3_26560356_Chip-Seq_TH2_Human1.03124878
100KDM2B_26808549_Chip-Seq_DND41_Human1.02860357
101MYC_22102868_ChIP-Seq_BL_Human1.02382107
102RUNX1_27514584_Chip-Seq_MCF-7_Human1.01480998
103JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01435738
104SMAD_19615063_ChIP-ChIP_OVARY_Human1.01121133
105STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00787613
106* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.00397353
107FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99958179
108RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99565653
109UBF1/2_26484160_Chip-Seq_HMECs_Human0.99478816
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98748095
111NCOR1_26117541_ChIP-Seq_K562_Human0.98662885
112MAF_26560356_Chip-Seq_TH2_Human0.98612710
113KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98530218
114KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98530218
115KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98530218
116* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98196994
117THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97940657
118JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97763004
119TCF4_18268006_ChIP-ChIP_LS174T_Human0.97469329
120VDR_24763502_ChIP-Seq_THP-1_Human0.97328646
121VDR_24787735_ChIP-Seq_THP-1_Human0.96237801
122GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95547155
123MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95450939
124NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94753777
125ESR1_20079471_ChIP-ChIP_T-47D_Human0.94673734
126ATF3_27146783_Chip-Seq_COLON_Human0.94445485
127ZNF263_19887448_ChIP-Seq_K562_Human0.94210025
128* RUNX1_22412390_ChIP-Seq_EML_Mouse0.92103446
129* FOXA2_19822575_ChIP-Seq_HepG2_Human0.92019164
130* TP63_23658742_ChIP-Seq_EP156T_Human0.90969436
131LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90871892
132ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90110056

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier2.95358948
2MP0005275_abnormal_skin_tensile2.84554802
3MP0010234_abnormal_vibrissa_follicle2.77440613
4MP0003705_abnormal_hypodermis_morpholog2.71231966
5MP0008260_abnormal_autophagy2.30581306
6MP0003300_gastrointestinal_ulcer2.28148581
7MP0002060_abnormal_skin_morphology2.24687891
8MP0010352_gastrointestinal_tract_polyps2.17932381
9MP0003453_abnormal_keratinocyte_physiol2.16737966
10MP0004947_skin_inflammation2.14465333
11MP0003941_abnormal_skin_development2.14396183
12MP0005501_abnormal_skin_physiology2.08290609
13MP0008438_abnormal_cutaneous_collagen2.06853592
14MP0003566_abnormal_cell_adhesion1.95182904
15MP0001851_eye_inflammation1.84155910
16MP0002166_altered_tumor_susceptibility1.80569864
17MP0001216_abnormal_epidermal_layer1.73297676
18MP0004883_abnormal_blood_vessel1.70712480
19MP0002254_reproductive_system_inflammat1.68735437
20MP0002398_abnormal_bone_marrow1.66430975
21MP0003866_abnormal_defecation1.66024732
22MP0002009_preneoplasia1.64289772
23MP0006054_spinal_hemorrhage1.59637856
24MP0010678_abnormal_skin_adnexa1.58763315
25MP0002006_tumorigenesis1.57600353
26MP0005023_abnormal_wound_healing1.55298936
27MP0010155_abnormal_intestine_physiology1.54586926
28MP0000383_abnormal_hair_follicle1.53744822
29MP0003191_abnormal_cellular_cholesterol1.53552695
30MP0003436_decreased_susceptibility_to1.51089976
31MP0005360_urolithiasis1.49839560
32MP0002098_abnormal_vibrissa_morphology1.49218421
33MP0005164_abnormal_response_to1.47180424
34MP0000716_abnormal_immune_system1.44125000
35MP0000685_abnormal_immune_system1.40685886
36MP0005451_abnormal_body_composition1.38301131
37MP0009384_cardiac_valve_regurgitation1.38267888
38MP0002722_abnormal_immune_system1.37591118
39MP0004147_increased_porphyrin_level1.34822271
40MP0000689_abnormal_spleen_morphology1.34794403
41MP0003252_abnormal_bile_duct1.34076557
42MP0003279_aneurysm1.33297480
43MP0009278_abnormal_bone_marrow1.32248539
44MP0004381_abnormal_hair_follicle1.29083988
45MP0000703_abnormal_thymus_morphology1.28692566
46MP0001873_stomach_inflammation1.28137097
47MP0003724_increased_susceptibility_to1.28108074
48MP0000377_abnormal_hair_follicle1.27605933
49MP0010771_integument_phenotype1.26965068
50MP0003656_abnormal_erythrocyte_physiolo1.26940485
51MP0004272_abnormal_basement_membrane1.23930735
52MP0009053_abnormal_anal_canal1.23839651
53MP0004185_abnormal_adipocyte_glucose1.22372533
54MP0001191_abnormal_skin_condition1.22258411
55MP0005085_abnormal_gallbladder_physiolo1.21041655
56MP0002429_abnormal_blood_cell1.20222408
57MP0001666_abnormal_nutrient_absorption1.19375562
58MP0010368_abnormal_lymphatic_system1.19339091
59MP0002998_abnormal_bone_remodeling1.19082165
60MP0003172_abnormal_lysosome_physiology1.18680223
61MP0005083_abnormal_biliary_tract1.17759914
62MP0009931_abnormal_skin_appearance1.16638981
63MP0005387_immune_system_phenotype1.16588319
64MP0001790_abnormal_immune_system1.16588319
65MP0001243_abnormal_dermal_layer1.15244557
66MP0003763_abnormal_thymus_physiology1.14856014
67MP0000579_abnormal_nail_morphology1.12105136
68MP0000467_abnormal_esophagus_morphology1.11309529
69MP0004808_abnormal_hematopoietic_stem1.10036108
70MP0003183_abnormal_peptide_metabolism1.09893668
71MP0005310_abnormal_salivary_gland1.09864577
72MP0001879_abnormal_lymphatic_vessel1.09397014
73MP0003828_pulmonary_edema1.07860633
74MP0001958_emphysema1.07427062
75MP0001849_ear_inflammation1.06944276
76MP0001545_abnormal_hematopoietic_system1.06693747
77MP0005397_hematopoietic_system_phenotyp1.06693747
78MP0005409_darkened_coat_color1.06213986
79MP0000249_abnormal_blood_vessel1.04701331
80MP0000858_altered_metastatic_potential1.03485477
81MP0009785_altered_susceptibility_to1.03255002
82MP0008004_abnormal_stomach_pH1.02881554
83MP0001800_abnormal_humoral_immune1.02776057
84MP0001835_abnormal_antigen_presentation1.02725699
85MP0000490_abnormal_crypts_of1.02586198
86* MP0005076_abnormal_cell_differentiation1.02021240
87MP0003303_peritoneal_inflammation1.01648927
88MP0004264_abnormal_extraembryonic_tissu1.01288816
89MP0008469_abnormal_protein_level1.00679517
90MP0005025_abnormal_response_to1.00223844
91MP0002419_abnormal_innate_immunity0.99414181
92MP0002138_abnormal_hepatobiliary_system0.99156521
93MP0001533_abnormal_skeleton_physiology0.98436866
94MP0000465_gastrointestinal_hemorrhage0.97874436
95MP0002405_respiratory_system_inflammati0.97823326
96MP0003448_altered_tumor_morphology0.97697653
97MP0002139_abnormal_hepatobiliary_system0.97493273
98MP0002452_abnormal_antigen_presenting0.97351337
99MP0009764_decreased_sensitivity_to0.96825842
100MP0004130_abnormal_muscle_cell0.96178704
101MP0002148_abnormal_hypersensitivity_rea0.94737822
102MP0005000_abnormal_immune_tolerance0.94158614
103MP0005167_abnormal_blood-brain_barrier0.93757455
104MP0005671_abnormal_response_to0.93214158
105MP0001346_abnormal_lacrimal_gland0.91716179
106MP0002933_joint_inflammation0.91546236
107MP0005464_abnormal_platelet_physiology0.91523781
108MP0005166_decreased_susceptibility_to0.91440455
109MP0002132_abnormal_respiratory_system0.90347974
110MP0000767_abnormal_smooth_muscle0.90011695
111MP0006082_CNS_inflammation0.89299374
112MP0003091_abnormal_cell_migration0.87335860
113MP0002877_abnormal_melanocyte_morpholog0.86737564
114MP0001845_abnormal_inflammatory_respons0.86544757
115MP0005367_renal/urinary_system_phenotyp0.86258949
116MP0000516_abnormal_urinary_system0.86258949
117MP0008875_abnormal_xenobiotic_pharmacok0.85631962
118MP0002396_abnormal_hematopoietic_system0.84837187
119MP0002420_abnormal_adaptive_immunity0.83856808
120MP0001819_abnormal_immune_cell0.83777617
121MP0009333_abnormal_splenocyte_physiolog0.82822306
122MP0000647_abnormal_sebaceous_gland0.81716717
123MP0002723_abnormal_immune_serum0.81709775
124MP0009763_increased_sensitivity_to0.80343556
125MP0003045_fibrosis0.80258835
126MP0000477_abnormal_intestine_morphology0.80044213
127MP0001663_abnormal_digestive_system0.77934499
128MP0004484_altered_response_of0.77787285
129MP0000609_abnormal_liver_physiology0.76293366
130MP0005365_abnormal_bile_salt0.76095117
131MP0003690_abnormal_glial_cell0.75425385
132MP0009115_abnormal_fat_cell0.74751300
133MP0005666_abnormal_adipose_tissue0.74608774
134MP0003075_altered_response_to0.70098336
135MP0001853_heart_inflammation0.69119800
136MP0005388_respiratory_system_phenotype0.67238875
137MP0002133_abnormal_respiratory_system0.67238875

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)4.16825807
2Gastrointestinal infarctions (HP:0005244)3.83228706
3Pustule (HP:0200039)3.61421390
4Right ventricular cardiomyopathy (HP:0011663)3.56608591
5Recurrent gram-negative bacterial infections (HP:0005420)3.39803725
6Optic neuritis (HP:0100653)3.34879272
7Retrobulbar optic neuritis (HP:0100654)3.34879272
8Elevated erythrocyte sedimentation rate (HP:0003565)3.28951268
9Abnormality of the heme biosynthetic pathway (HP:0010472)3.26289628
10Epistaxis (HP:0000421)3.19433367
11Abnormality of macrophages (HP:0004311)3.15711253
12Recurrent skin infections (HP:0001581)3.06435316
13Keratoconjunctivitis sicca (HP:0001097)3.05831897
14Stomatitis (HP:0010280)3.02909037
15Atrophic scars (HP:0001075)2.99681293
16Onycholysis (HP:0001806)2.95072205
17Abnormal delayed hypersensitivity skin test (HP:0002963)2.92338467
18Eczematoid dermatitis (HP:0000976)2.88363312
19Keratoconjunctivitis (HP:0001096)2.84157247
20Increased IgE level (HP:0003212)2.81603918
21Microcytic anemia (HP:0001935)2.78619253
22Plantar hyperkeratosis (HP:0007556)2.68044469
23Thick nail (HP:0001805)2.67630546
24Milia (HP:0001056)2.65205167
25Premature rupture of membranes (HP:0001788)2.63016945
26Aortic aneurysm (HP:0004942)2.60915024
27Hematochezia (HP:0002573)2.59449526
28Osteolytic defects of the hand bones (HP:0009699)2.54368469
29Osteolytic defects of the phalanges of the hand (HP:0009771)2.54368469
30Woolly hair (HP:0002224)2.54358346
31Lip pit (HP:0100267)2.53087656
32Protrusio acetabuli (HP:0003179)2.53035428
33Vasculitis (HP:0002633)2.52186995
34Aortic dissection (HP:0002647)2.48521760
35Autoimmune hemolytic anemia (HP:0001890)2.46479984
36Alopecia of scalp (HP:0002293)2.46088757
37Autoimmune thrombocytopenia (HP:0001973)2.46076512
38Encephalitis (HP:0002383)2.45609091
39Fragile skin (HP:0001030)2.43729503
40Poikilocytosis (HP:0004447)2.39406622
41Chronic mucocutaneous candidiasis (HP:0002728)2.37322080
42Recurrent cutaneous fungal infections (HP:0011370)2.37322080
43Meningitis (HP:0001287)2.36559832
44Cerebral aneurysm (HP:0004944)2.34862665
45Palmoplantar hyperkeratosis (HP:0000972)2.33462009
46Chest pain (HP:0100749)2.33336958
47Slow saccadic eye movements (HP:0000514)2.30705845
48Recurrent viral infections (HP:0004429)2.27370727
49Hemoptysis (HP:0002105)2.26620120
50Papillary thyroid carcinoma (HP:0002895)2.25153594
51Rectal prolapse (HP:0002035)2.24956474
52Arterial thrombosis (HP:0004420)2.24372834
53Myocardial infarction (HP:0001658)2.24022905
54Pulmonary infiltrates (HP:0002113)2.22939008
55Leukocytosis (HP:0001974)2.22615208
56Menorrhagia (HP:0000132)2.22428257
57Palmar hyperkeratosis (HP:0010765)2.22225289
58Peritonitis (HP:0002586)2.21577795
59Spontaneous hematomas (HP:0007420)2.21133737
60Abnormality of T cells (HP:0002843)2.20984985
61Broad metatarsal (HP:0001783)2.19461001
62Esophageal varix (HP:0002040)2.17882033
63Abnormality of nail color (HP:0100643)2.15852163
64Inflammation of the large intestine (HP:0002037)2.14870554
65Ectropion (HP:0000656)2.09945922
66Obstructive lung disease (HP:0006536)2.09898449
67Chronic obstructive pulmonary disease (HP:0006510)2.09898449
68Mediastinal lymphadenopathy (HP:0100721)2.09342604
69Periodontitis (HP:0000704)2.09064415
70Mitral valve prolapse (HP:0001634)2.08863616
71Petechiae (HP:0000967)2.07418160
72Pulmonary embolism (HP:0002204)2.07080074
73Osteomyelitis (HP:0002754)2.06083528
74Shallow orbits (HP:0000586)2.05569535
75Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.05361133
76Ileus (HP:0002595)2.03266947
77Abnormal platelet volume (HP:0011876)2.02801580
78Gastrointestinal inflammation (HP:0004386)2.02230202
79Increased mean platelet volume (HP:0011877)1.99966707
80Cellulitis (HP:0100658)1.98749003
81Acanthocytosis (HP:0001927)1.98002582
82Anorexia (HP:0002039)1.96879549
83Hypotrichosis (HP:0001006)1.95748213
84Purpura (HP:0000979)1.94315445
85Toxemia of pregnancy (HP:0100603)1.92523375
86Increased connective tissue (HP:0009025)1.91166718
87Abnormality of the distal phalanges of the toes (HP:0010182)1.90633989
88Fragile nails (HP:0001808)1.89465435
89Dilatation of the ascending aorta (HP:0005111)1.86951866
90Hypergammaglobulinemia (HP:0010702)1.86886951
91Parakeratosis (HP:0001036)1.86605620
92Systemic lupus erythematosus (HP:0002725)1.85980519
93Impaired platelet aggregation (HP:0003540)1.83762778
94Abnormal platelet function (HP:0011869)1.83762778
95Abnormality of T cell number (HP:0011839)1.83585847
96Abnormality of T cell physiology (HP:0011840)1.82748099
97Abnormality of the fingertips (HP:0001211)1.82686564
98Viral hepatitis (HP:0006562)1.82359814
99Abnormality of the common coagulation pathway (HP:0010990)1.81312003
100Increased CSF protein (HP:0002922)1.80829604
101Thrombophlebitis (HP:0004418)1.80672562
102T lymphocytopenia (HP:0005403)1.79662288
103Coarse hair (HP:0002208)1.78824239
104Flat acetabular roof (HP:0003180)1.78033072
105Neoplasm of the tracheobronchial system (HP:0100552)1.77776236
106Hemorrhage of the eye (HP:0011885)1.77056452
107Ankle contracture (HP:0006466)1.76367371
108Keratitis (HP:0000491)1.75568805
109Abnormal blistering of the skin (HP:0008066)1.75123093
110Colitis (HP:0002583)1.74593080
111Urticaria (HP:0001025)1.74567865
112Segmental peripheral demyelination/remyelination (HP:0003481)1.74485962
113Xanthomatosis (HP:0000991)1.73499722
114Recurrent abscess formation (HP:0002722)1.73046210
115Abnormality of the nasal septum (HP:0000419)1.72837175
116Deep venous thrombosis (HP:0002625)1.72369484
117Vascular tortuosity (HP:0004948)1.71821743
118Episodic fever (HP:0001954)1.71539548
119Granulocytopenia (HP:0001913)1.71316926
120Arterial tortuosity (HP:0005116)1.70926731
121Erythema (HP:0010783)1.70086304
122Verrucae (HP:0200043)1.68563907
123Papilloma (HP:0012740)1.68563907
124Hypochromic microcytic anemia (HP:0004840)1.68521944
125Gingivitis (HP:0000230)1.68346275
126Panhypogammaglobulinemia (HP:0003139)1.68009006
127Hyperactive renin-angiotensin system (HP:0000841)1.67715729
128Amyloidosis (HP:0011034)1.67489857
129Abnormality of the gastric mucosa (HP:0004295)1.66997741
130Ureteral obstruction (HP:0006000)1.66876798
131Urethral obstruction (HP:0000796)1.66703142
132Abnormal foot bone ossification (HP:0010675)1.66491363
133Joint swelling (HP:0001386)1.66264941
134Congenital ichthyosiform erythroderma (HP:0007431)1.66153917
135Hyperlipoproteinemia (HP:0010980)1.65930291
136Ulnar bowing (HP:0003031)1.65353063
137Advanced eruption of teeth (HP:0006288)1.64994938
138Cupped ribs (HP:0000887)1.64773159
139Cervical subluxation (HP:0003308)1.64316534
140Gangrene (HP:0100758)1.64181453
141Ureteral stenosis (HP:0000071)1.64108905
142Ventricular tachycardia (HP:0004756)1.64037430
143Gingival bleeding (HP:0000225)1.63980438
144Subacute progressive viral hepatitis (HP:0006572)1.63927259
145Polycythemia (HP:0001901)1.63510998
146Nephritis (HP:0000123)1.62846159
147Distal lower limb muscle weakness (HP:0009053)1.62524296
148Aplasia cutis congenita (HP:0001057)1.61147435
149Abnormality of monocarboxylic acid metabolism (HP:0010996)1.61108905
150Pili torti (HP:0003777)1.60482713
151Abnormal hemoglobin (HP:0011902)1.60130458
152Hypochromic anemia (HP:0001931)1.59372231
153Disproportionate tall stature (HP:0001519)1.59104840
154Pruritus (HP:0000989)1.58880256
155Skin ulcer (HP:0200042)1.58873300
156Abnormality of complement system (HP:0005339)1.58513496
157Nonimmune hydrops fetalis (HP:0001790)1.58243523
158Congenital, generalized hypertrichosis (HP:0004540)1.57409243
159Orchitis (HP:0100796)1.55471389
160Prolonged bleeding time (HP:0003010)1.54786301
161Aneurysm (HP:0002617)1.54739962
162Spinal cord lesions (HP:0100561)1.54055806
163Syringomyelia (HP:0003396)1.54055806
164Complement deficiency (HP:0004431)1.53887253
165Abnormality of the distal phalanx of the thumb (HP:0009617)1.53374139
166Myositis (HP:0100614)1.52521484
167Recurrent fungal infections (HP:0002841)1.52293018
168Hepatocellular carcinoma (HP:0001402)1.51534378

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.35205127
2PRPF4B3.13386574
3STK102.76387585
4TGFBR22.67484932
5ERN12.47723801
6MST42.31953196
7MAP3K142.11728259
8MST1R2.05585069
9FES1.98932572
10LATS11.87155313
11CDK121.86682801
12FRK1.83612586
13FGFR41.82296919
14SIK31.78811244
15EPHA21.72040195
16SIK11.71889065
17MAP3K31.69700618
18YES11.69403943
19MAP4K11.69375672
20TRIB31.66789621
21TYK21.63027779
22EPHB11.62111240
23IKBKE1.59891269
24PTK61.52699385
25BTK1.51889679
26TTN1.50422460
27TRPM71.49927093
28RIPK11.47248819
29CSK1.44876048
30FGFR31.43782625
31LRRK21.43373760
32EPHB21.43024443
33MAP3K101.43015825
34TBK11.38349671
35CDK61.35566412
36JAK11.31888192
37ITK1.31383647
38KDR1.30139733
39BMPR21.29118586
40JAK31.28233908
41TXK1.26995263
42SYK1.26287651
43BLK1.26078695
44FGR1.24653397
45SGK21.24105262
46NUAK11.22660628
47MARK31.21923862
48STK31.21790218
49EPHA31.21355726
50MAP3K11.21153768
51NLK1.20878016
52RPS6KA41.20501527
53CAMK1D1.19897489
54SGK31.19195387
55KSR21.17048421
56PKN21.15779900
57GRK61.15590859
58MARK21.14894893
59HIPK21.13154648
60AKT31.10483030
61STK41.09492065
62IRAK11.08830362
63IKBKB1.06549691
64MAPKAPK31.01943544
65WNK11.00095416
66FGFR20.99679308
67CLK10.99398141
68CHUK0.99374650
69RPS6KB20.99342314
70DMPK0.97767699
71ACVR1B0.97166837
72TAOK20.96683399
73DDR20.95162006
74MET0.94873604
75MAP3K60.94574181
76CAMKK20.94418384
77PIM10.94321072
78FER0.94158915
79LYN0.93435134
80MAP2K30.93330224
81EEF2K0.92582217
82PTK20.92117185
83TNK20.90460529
84MAP2K20.87262643
85PTK2B0.86781172
86PIK3CA0.86102181
87PDGFRA0.85092119
88PDGFRB0.83605035
89IRAK30.82513839
90ZAP700.80341273
91MELK0.79659274
92MAP3K70.78772176
93STK240.78193562
94TEC0.77537105
95DYRK1B0.76354725
96BMX0.74710194
97PAK40.74159066
98FLT30.73957534
99PDK10.70964531
100RET0.70255475
101JAK20.68943106
102ERBB20.68192436
103SGK2230.67849289
104SGK4940.67849289
105STK380.66783988
106IRAK40.66645549
107HCK0.66556798
108MAP3K130.66426713
109MAPK120.65946302
110IRAK20.65050885
111TIE10.64068419
112MAPK110.63778379
113STK110.63541524
114LCK0.63517016
115MAPKAPK20.63060126
116NEK90.60776126
117FGFR10.60373319
118CDK90.58412857
119MAP3K20.58176208
120KSR10.55551523
121MAP3K50.55490462
122PRKAA20.55336499
123PRKG20.54650793
124MAP3K80.54595733
125CDC42BPA0.53847643
126PDPK10.52261572
127MTOR0.50678317
128PRKD20.50472145
129CSF1R0.49398894
130TAOK30.47919441
131PRKCQ0.46917648
132PRKD10.46630579
133TYRO30.46485015
134MAPK70.46244955
135BRD40.45988454
136CAMK1G0.44487943
137GSK3A0.44464893
138TAOK10.43509517
139ABL10.43053823
140PIK3CG0.43048650
141LMTK20.42623610

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.30185689
2Caffeine metabolism_Homo sapiens_hsa002321.95137309
3Adherens junction_Homo sapiens_hsa045201.84030906
4Leukocyte transendothelial migration_Homo sapiens_hsa046701.77345680
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.71369672
6Leishmaniasis_Homo sapiens_hsa051401.63552491
7ECM-receptor interaction_Homo sapiens_hsa045121.61850562
8Nitrogen metabolism_Homo sapiens_hsa009101.61044053
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.59090055
10Malaria_Homo sapiens_hsa051441.58771269
11Hematopoietic cell lineage_Homo sapiens_hsa046401.51943256
12Non-small cell lung cancer_Homo sapiens_hsa052231.50724059
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.46362300
14Complement and coagulation cascades_Homo sapiens_hsa046101.45721119
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44164680
16Small cell lung cancer_Homo sapiens_hsa052221.42850947
17Toxoplasmosis_Homo sapiens_hsa051451.41159066
18Osteoclast differentiation_Homo sapiens_hsa043801.38684611
19Sulfur metabolism_Homo sapiens_hsa009201.34881495
20ABC transporters_Homo sapiens_hsa020101.34525894
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.33146340
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32911582
23Measles_Homo sapiens_hsa051621.29267780
24Dorso-ventral axis formation_Homo sapiens_hsa043201.28338855
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.28334198
26Chemical carcinogenesis_Homo sapiens_hsa052041.28034428
27Renal cell carcinoma_Homo sapiens_hsa052111.27831389
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26505665
29TNF signaling pathway_Homo sapiens_hsa046681.24640472
30Primary immunodeficiency_Homo sapiens_hsa053401.23438834
31Allograft rejection_Homo sapiens_hsa053301.22378196
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17605518
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.17541919
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15497649
35Autoimmune thyroid disease_Homo sapiens_hsa053201.15493039
36Pertussis_Homo sapiens_hsa051331.15009969
37Focal adhesion_Homo sapiens_hsa045101.12477330
38Choline metabolism in cancer_Homo sapiens_hsa052311.11149139
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11046426
40Mineral absorption_Homo sapiens_hsa049781.10818873
41Proteoglycans in cancer_Homo sapiens_hsa052051.10799471
42Histidine metabolism_Homo sapiens_hsa003401.10506071
43Chronic myeloid leukemia_Homo sapiens_hsa052201.09866320
44Fat digestion and absorption_Homo sapiens_hsa049751.08935155
45Amoebiasis_Homo sapiens_hsa051461.07819176
46Hepatitis C_Homo sapiens_hsa051601.07119373
47African trypanosomiasis_Homo sapiens_hsa051431.06752990
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05997760
49VEGF signaling pathway_Homo sapiens_hsa043701.05007205
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03077754
51T cell receptor signaling pathway_Homo sapiens_hsa046601.02801689
52Influenza A_Homo sapiens_hsa051641.02034346
53Inositol phosphate metabolism_Homo sapiens_hsa005621.02020808
54Acute myeloid leukemia_Homo sapiens_hsa052211.01795935
55Bladder cancer_Homo sapiens_hsa052191.01384445
56Pancreatic cancer_Homo sapiens_hsa052121.00301927
57Graft-versus-host disease_Homo sapiens_hsa053320.97077500
58Jak-STAT signaling pathway_Homo sapiens_hsa046300.96950721
59Prolactin signaling pathway_Homo sapiens_hsa049170.95939122
60MicroRNAs in cancer_Homo sapiens_hsa052060.95829068
61Prostate cancer_Homo sapiens_hsa052150.95741118
62Retinol metabolism_Homo sapiens_hsa008300.95185649
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94803575
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92414465
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91830071
66Herpes simplex infection_Homo sapiens_hsa051680.91643027
67Protein digestion and absorption_Homo sapiens_hsa049740.91258063
68Apoptosis_Homo sapiens_hsa042100.90598016
69Antigen processing and presentation_Homo sapiens_hsa046120.90173554
70B cell receptor signaling pathway_Homo sapiens_hsa046620.89574668
71Lysine degradation_Homo sapiens_hsa003100.89460638
72Hepatitis B_Homo sapiens_hsa051610.88999361
73Legionellosis_Homo sapiens_hsa051340.87388510
74TGF-beta signaling pathway_Homo sapiens_hsa043500.87270065
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.86351614
76Insulin resistance_Homo sapiens_hsa049310.86219864
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83960359
78mTOR signaling pathway_Homo sapiens_hsa041500.83124792
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.82880471
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.82501849
81Colorectal cancer_Homo sapiens_hsa052100.82457780
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82417637
83Platelet activation_Homo sapiens_hsa046110.80545839
84Viral myocarditis_Homo sapiens_hsa054160.79851936
85PPAR signaling pathway_Homo sapiens_hsa033200.79743612
86GnRH signaling pathway_Homo sapiens_hsa049120.77849951
87* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77666495
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76977666
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.76753489
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76655994
91Tryptophan metabolism_Homo sapiens_hsa003800.76614835
92Tuberculosis_Homo sapiens_hsa051520.75797288
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.75554541
94Endocytosis_Homo sapiens_hsa041440.74444838
95Starch and sucrose metabolism_Homo sapiens_hsa005000.74146769
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73305664
97Notch signaling pathway_Homo sapiens_hsa043300.73196997
98ErbB signaling pathway_Homo sapiens_hsa040120.72372829
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71146075
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70509624
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70233816
102Other glycan degradation_Homo sapiens_hsa005110.70169609
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69871132
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69406463
105Salmonella infection_Homo sapiens_hsa051320.68830280
106Bile secretion_Homo sapiens_hsa049760.68500662
107Circadian rhythm_Homo sapiens_hsa047100.67316612
108p53 signaling pathway_Homo sapiens_hsa041150.66925324
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66815952
110Arginine biosynthesis_Homo sapiens_hsa002200.66771737
111HIF-1 signaling pathway_Homo sapiens_hsa040660.66021752
112Shigellosis_Homo sapiens_hsa051310.65701018
113Type I diabetes mellitus_Homo sapiens_hsa049400.65480671
114Systemic lupus erythematosus_Homo sapiens_hsa053220.65198215
115Fatty acid degradation_Homo sapiens_hsa000710.64767747
116Vitamin digestion and absorption_Homo sapiens_hsa049770.63230643
117FoxO signaling pathway_Homo sapiens_hsa040680.62924239
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62603349
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.62474002
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61258375
121Phagosome_Homo sapiens_hsa041450.59174919
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58600408
123Selenocompound metabolism_Homo sapiens_hsa004500.57151171
124Basal cell carcinoma_Homo sapiens_hsa052170.57107833
125Thyroid cancer_Homo sapiens_hsa052160.57100116
126Pathways in cancer_Homo sapiens_hsa052000.56650503
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56306254
128Glioma_Homo sapiens_hsa052140.55927547
129HTLV-I infection_Homo sapiens_hsa051660.55034381
130Tight junction_Homo sapiens_hsa045300.54267882
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53437217
132Hippo signaling pathway_Homo sapiens_hsa043900.52901962
133Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52752856
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.52537229
135Chemokine signaling pathway_Homo sapiens_hsa040620.52466448
136Endometrial cancer_Homo sapiens_hsa052130.52254112
137Insulin signaling pathway_Homo sapiens_hsa049100.51598068
138SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50345528
139Long-term potentiation_Homo sapiens_hsa047200.49514687
140Rap1 signaling pathway_Homo sapiens_hsa040150.48800441

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