KLF3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.42764682
2maturation of SSU-rRNA (GO:0030490)5.89946486
3viral transcription (GO:0019083)5.77704923
4behavioral response to nicotine (GO:0035095)5.73021296
5translational termination (GO:0006415)5.61239052
6phenol-containing compound catabolic process (GO:0019336)5.07107707
7ribosomal small subunit assembly (GO:0000028)4.95046433
8kidney morphogenesis (GO:0060993)4.59905078
9Sertoli cell development (GO:0060009)4.57893286
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.39751948
11ribosomal small subunit biogenesis (GO:0042274)4.36896426
12cotranslational protein targeting to membrane (GO:0006613)4.34354462
13translational elongation (GO:0006414)4.33308234
14cellular protein complex disassembly (GO:0043624)4.28745271
15protein targeting to ER (GO:0045047)4.24667864
16viral life cycle (GO:0019058)4.15588166
17hormone catabolic process (GO:0042447)4.13906939
18neuron fate determination (GO:0048664)4.13818229
19regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.13753829
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.13369557
21epithelial cilium movement (GO:0003351)4.11842112
22establishment of protein localization to endoplasmic reticulum (GO:0072599)4.05260825
23single strand break repair (GO:0000012)3.96247950
24ribosomal large subunit biogenesis (GO:0042273)3.94477469
25protein localization to endoplasmic reticulum (GO:0070972)3.91275554
26regulation of calcium ion-dependent exocytosis (GO:0017158)3.74427386
27protein complex disassembly (GO:0043241)3.72513752
28negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.67143415
29regulation of centriole replication (GO:0046599)3.65165900
30axonal fasciculation (GO:0007413)3.64371369
31macromolecular complex disassembly (GO:0032984)3.55978442
32thyroid hormone generation (GO:0006590)3.53819093
33translational initiation (GO:0006413)3.50922261
34negative regulation of organelle assembly (GO:1902116)3.48565930
35neuronal stem cell maintenance (GO:0097150)3.47372018
36olfactory bulb development (GO:0021772)3.41234973
37DNA strand elongation involved in DNA replication (GO:0006271)3.36524956
38replication fork processing (GO:0031297)3.33160614
39axon extension involved in axon guidance (GO:0048846)3.32375545
40neuron projection extension involved in neuron projection guidance (GO:1902284)3.32375545
41maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.30601248
42regulation of DNA endoreduplication (GO:0032875)3.30077543
43thyroid hormone metabolic process (GO:0042403)3.28731676
44synaptic transmission, cholinergic (GO:0007271)3.26517505
45cell proliferation in forebrain (GO:0021846)3.26256895
46spermatid nucleus differentiation (GO:0007289)3.19191556
47urinary tract smooth muscle contraction (GO:0014848)3.17514354
48DNA strand elongation (GO:0022616)3.12272244
49telomere maintenance via semi-conservative replication (GO:0032201)3.12038936
50mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.11384514
51determination of left/right symmetry (GO:0007368)3.08942453
52negative regulation of transcription regulatory region DNA binding (GO:2000678)3.05990906
53regulation of non-canonical Wnt signaling pathway (GO:2000050)3.04832730
54negative regulation of DNA-dependent DNA replication (GO:2000104)3.02884736
55head development (GO:0060322)2.98266987
56nuclear-transcribed mRNA catabolic process (GO:0000956)2.90333762
57auditory receptor cell differentiation (GO:0042491)2.90268854
58DNA replication checkpoint (GO:0000076)2.88487094
59protein insertion into membrane (GO:0051205)2.87311623
60sequestering of actin monomers (GO:0042989)2.85321040
61determination of bilateral symmetry (GO:0009855)2.82212454
62resolution of meiotic recombination intermediates (GO:0000712)2.78444062
63protein targeting to membrane (GO:0006612)2.78371697
64peristalsis (GO:0030432)2.77939985
65ribonucleoprotein complex biogenesis (GO:0022613)2.77369460
66energy coupled proton transport, down electrochemical gradient (GO:0015985)2.76773449
67ATP synthesis coupled proton transport (GO:0015986)2.76773449
68negative regulation of JUN kinase activity (GO:0043508)2.73950600
69specification of symmetry (GO:0009799)2.71758183
70rRNA catabolic process (GO:0016075)2.71687736
71endothelial cell chemotaxis (GO:0035767)2.71305844
72mRNA catabolic process (GO:0006402)2.68451009
73melanosome organization (GO:0032438)2.68052472
74protein complex biogenesis (GO:0070271)2.66410343
75regulation of nuclear cell cycle DNA replication (GO:0033262)2.63827215
76telomere maintenance via telomerase (GO:0007004)2.61322853
77cilium movement (GO:0003341)2.60961580
78melanosome localization (GO:0032400)2.60794084
79negative regulation of mast cell activation (GO:0033004)2.60631020
80negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.60243973
81snRNA transcription (GO:0009301)2.59299255
82cellular component biogenesis (GO:0044085)2.58847861
83translesion synthesis (GO:0019985)2.58735243
84endosome to melanosome transport (GO:0035646)2.58544334
85endosome to pigment granule transport (GO:0043485)2.58544334
86fatty acid transmembrane transport (GO:1902001)2.58541282
87cranial nerve development (GO:0021545)2.57525122
88short-term memory (GO:0007614)2.55603732
89telomere maintenance via recombination (GO:0000722)2.55262267
90radial glial cell differentiation (GO:0060019)2.54417960
91negative regulation of appetite (GO:0032099)2.53981322
92negative regulation of response to food (GO:0032096)2.53981322
93mRNA splice site selection (GO:0006376)2.53916006
94transmission of nerve impulse (GO:0019226)2.53476746
95regulation of cilium movement (GO:0003352)2.53399910
96neuromuscular synaptic transmission (GO:0007274)2.51944318
97positive regulation of vesicle fusion (GO:0031340)2.51399854
98neuron recognition (GO:0008038)2.50443109
99pigment granule localization (GO:0051875)2.50434617
100RNA catabolic process (GO:0006401)2.49840427

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.74636246
2EZH2_22144423_ChIP-Seq_EOC_Human4.03524885
3CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.12868437
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.11961321
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.08445810
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.54350939
7FUS_26573619_Chip-Seq_HEK293_Human2.38837321
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.38795230
9VDR_22108803_ChIP-Seq_LS180_Human2.35770468
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35620194
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31386935
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.27961633
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25883626
14IRF1_19129219_ChIP-ChIP_H3396_Human2.21982008
15ZNF274_21170338_ChIP-Seq_K562_Hela2.06629453
16EST1_17652178_ChIP-ChIP_JURKAT_Human1.97793831
17GABP_17652178_ChIP-ChIP_JURKAT_Human1.92560943
18POU5F1_16153702_ChIP-ChIP_HESCs_Human1.87254527
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84643423
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84350581
21P300_19829295_ChIP-Seq_ESCs_Human1.72639850
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71555610
23EWS_26573619_Chip-Seq_HEK293_Human1.64881040
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.62976283
25AR_21909140_ChIP-Seq_LNCAP_Human1.62080061
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61929988
27ELK1_19687146_ChIP-ChIP_HELA_Human1.59483173
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58288271
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.53699733
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52201525
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.50473159
32RNF2_27304074_Chip-Seq_NSC_Mouse1.50100619
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.49286014
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49273639
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48687574
36SMAD3_21741376_ChIP-Seq_EPCs_Human1.43878171
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36634447
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36386930
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33397483
40TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.30831342
41SOX2_16153702_ChIP-ChIP_HESCs_Human1.28247353
42ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25717372
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25378525
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.25301648
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23334636
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21932135
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20493170
48RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19867601
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.19549128
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18707630
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18269196
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18100566
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18100566
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.17941558
55GATA3_21878914_ChIP-Seq_MCF-7_Human1.17277143
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16512889
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16135989
58MYC_18940864_ChIP-ChIP_HL60_Human1.14872010
59STAT3_23295773_ChIP-Seq_U87_Human1.14105933
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12831968
61TP53_22573176_ChIP-Seq_HFKS_Human1.10182070
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09511407
63JUN_21703547_ChIP-Seq_K562_Human1.08877195
64REST_21632747_ChIP-Seq_MESCs_Mouse1.08427977
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.07625280
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07447248
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07087278
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04187142
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02750976
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.00938824
71TTF2_22483619_ChIP-Seq_HELA_Human0.99799558
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99135056
73TCF4_22108803_ChIP-Seq_LS180_Human0.98208887
74CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97216530
75NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97156080
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96985186
77CBP_20019798_ChIP-Seq_JUKART_Human0.95457972
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95457972
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95232291
80PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94664488
81EED_16625203_ChIP-ChIP_MESCs_Mouse0.94561722
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94196303
83GATA1_26923725_Chip-Seq_HPCs_Mouse0.93817869
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93595257
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92474610
86NANOG_19829295_ChIP-Seq_ESCs_Human0.91322226
87SOX2_19829295_ChIP-Seq_ESCs_Human0.91322226
88NFE2_27457419_Chip-Seq_LIVER_Mouse0.90760560
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90701707
90NANOG_16153702_ChIP-ChIP_HESCs_Human0.90201312
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90184232
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89757700
93MYC_19079543_ChIP-ChIP_MESCs_Mouse0.89120465
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89096944
95SMAD4_21799915_ChIP-Seq_A2780_Human0.88714306
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88324297
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86791166
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85958242
99AR_21572438_ChIP-Seq_LNCaP_Human0.85332391
100GBX2_23144817_ChIP-Seq_PC3_Human0.85224323

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.73562840
2MP0003122_maternal_imprinting4.66990594
3MP0005408_hypopigmentation4.35567935
4MP0006292_abnormal_olfactory_placode3.33538380
5MP0002938_white_spotting3.12938457
6MP0003121_genomic_imprinting2.90008227
7MP0005377_hearing/vestibular/ear_phenot2.81123945
8MP0003878_abnormal_ear_physiology2.81123945
9MP0010030_abnormal_orbit_morphology2.51479577
10MP0008058_abnormal_DNA_repair2.50418640
11MP0000569_abnormal_digit_pigmentation2.47096653
12MP0003787_abnormal_imprinting2.38310904
13MP0002638_abnormal_pupillary_reflex2.32620176
14MP0008057_abnormal_DNA_replication2.28790657
15MP0004133_heterotaxia2.26361063
16MP0006276_abnormal_autonomic_nervous2.12576561
17MP0000372_irregular_coat_pigmentation2.07206924
18MP0001293_anophthalmia2.03689689
19MP0003136_yellow_coat_color1.95728717
20MP0005174_abnormal_tail_pigmentation1.91401650
21MP0001529_abnormal_vocalization1.82464990
22MP0002095_abnormal_skin_pigmentation1.79845364
23MP0000778_abnormal_nervous_system1.78726749
24MP0000371_diluted_coat_color1.75425606
25MP0008877_abnormal_DNA_methylation1.75205433
26MP0005075_abnormal_melanosome_morpholog1.67220919
27MP0004142_abnormal_muscle_tone1.66763996
28MP0000049_abnormal_middle_ear1.63482466
29MP0002653_abnormal_ependyma_morphology1.52892914
30MP0001485_abnormal_pinna_reflex1.49972597
31MP0004885_abnormal_endolymph1.44682518
32MP0001324_abnormal_eye_pigmentation1.43074771
33MP0000631_abnormal_neuroendocrine_gland1.39679439
34MP0003937_abnormal_limbs/digits/tail_de1.39619621
35MP0006072_abnormal_retinal_apoptosis1.36696043
36MP0003890_abnormal_embryonic-extraembry1.35916647
37MP0002697_abnormal_eye_size1.29173525
38MP0003806_abnormal_nucleotide_metabolis1.28896340
39MP0004742_abnormal_vestibular_system1.24832741
40MP0005386_behavior/neurological_phenoty1.23319204
41MP0004924_abnormal_behavior1.23319204
42MP0008789_abnormal_olfactory_epithelium1.21805863
43MP0002876_abnormal_thyroid_physiology1.19929593
44MP0001286_abnormal_eye_development1.18925706
45MP0001984_abnormal_olfaction1.16991836
46MP0003693_abnormal_embryo_hatching1.15226138
47MP0002557_abnormal_social/conspecific_i1.14616439
48MP0001486_abnormal_startle_reflex1.09989777
49MP0010386_abnormal_urinary_bladder1.09984899
50MP0002752_abnormal_somatic_nervous1.09915762
51MP0009046_muscle_twitch1.05618415
52MP0003011_delayed_dark_adaptation1.04987859
53MP0005197_abnormal_uvea_morphology1.04522034
54MP0003950_abnormal_plasma_membrane1.03508904
55MP0005171_absent_coat_pigmentation1.03301887
56MP0002163_abnormal_gland_morphology1.02405631
57MP0002272_abnormal_nervous_system1.01928273
58MP0010094_abnormal_chromosome_stability0.99992025
59MP0005499_abnormal_olfactory_system0.99984530
60MP0005394_taste/olfaction_phenotype0.99984530
61MP0003880_abnormal_central_pattern0.99898549
62MP0003861_abnormal_nervous_system0.99450560
63MP0000026_abnormal_inner_ear0.98652951
64MP0003279_aneurysm0.97646468
65MP0000427_abnormal_hair_cycle0.97172806
66MP0002233_abnormal_nose_morphology0.95494719
67MP0001968_abnormal_touch/_nociception0.94482324
68MP0008932_abnormal_embryonic_tissue0.94070729
69MP0002928_abnormal_bile_duct0.93857550
70MP0005551_abnormal_eye_electrophysiolog0.93516796
71MP0005195_abnormal_posterior_eye0.90427938
72MP0002735_abnormal_chemical_nociception0.86605169
73MP0001963_abnormal_hearing_physiology0.86129453
74MP0002075_abnormal_coat/hair_pigmentati0.83289181
75MP0000955_abnormal_spinal_cord0.83032279
76MP0002184_abnormal_innervation0.82479717
77MP0001186_pigmentation_phenotype0.81023208
78MP0005253_abnormal_eye_physiology0.80775145
79MP0005084_abnormal_gallbladder_morpholo0.80288345
80MP0009745_abnormal_behavioral_response0.79501352
81MP0001970_abnormal_pain_threshold0.79497737
82MP0003755_abnormal_palate_morphology0.78660139
83MP0002210_abnormal_sex_determination0.78399921
84MP0005391_vision/eye_phenotype0.76317103
85MP0004145_abnormal_muscle_electrophysio0.75426924
86MP0005248_abnormal_Harderian_gland0.74639318
87MP0002572_abnormal_emotion/affect_behav0.74196906
88MP0002067_abnormal_sensory_capabilities0.72362320
89MP0002234_abnormal_pharynx_morphology0.71221336
90MP0002152_abnormal_brain_morphology0.70977222
91MP0001905_abnormal_dopamine_level0.69799136
92MP0002084_abnormal_developmental_patter0.68643540
93MP0002249_abnormal_larynx_morphology0.67920954
94MP0000432_abnormal_head_morphology0.66687059
95MP0005193_abnormal_anterior_eye0.66448314
96MP0002882_abnormal_neuron_morphology0.65623293
97MP0002177_abnormal_outer_ear0.65389022
98MP0005367_renal/urinary_system_phenotyp0.64545890
99MP0000516_abnormal_urinary_system0.64545890
100MP0000015_abnormal_ear_pigmentation0.64261964

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.98507337
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.40772622
3Chromsome breakage (HP:0040012)5.01099002
4Pancreatic fibrosis (HP:0100732)4.66691920
5Tubular atrophy (HP:0000092)4.13830553
6Abnormal biliary tract physiology (HP:0012439)4.09977016
7Bile duct proliferation (HP:0001408)4.09977016
8Supernumerary spleens (HP:0009799)4.06432109
9Pancreatic cysts (HP:0001737)3.76354955
10Asplenia (HP:0001746)3.75939766
11Aplasia/Hypoplasia of the spleen (HP:0010451)3.56291103
12Oligodactyly (hands) (HP:0001180)3.38923378
13Septo-optic dysplasia (HP:0100842)3.38779231
14Ectopic kidney (HP:0000086)3.33377260
15Abnormality of cells of the erythroid lineage (HP:0012130)3.27519330
16Rib fusion (HP:0000902)3.23262634
17Increased hepatocellular lipid droplets (HP:0006565)3.23179518
18Tubulointerstitial fibrosis (HP:0005576)3.13150617
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.04950707
20Growth hormone deficiency (HP:0000824)3.03769491
21Cystic liver disease (HP:0006706)3.03114397
22Lipid accumulation in hepatocytes (HP:0006561)2.99230779
23Abnormality of the renal medulla (HP:0100957)2.98868862
24Absent thumb (HP:0009777)2.97410329
25Duplicated collecting system (HP:0000081)2.92051635
26Polydipsia (HP:0001959)2.91408874
27Abnormal drinking behavior (HP:0030082)2.91408874
28Elfin facies (HP:0004428)2.89815032
29Meckel diverticulum (HP:0002245)2.86653174
30Congenital hepatic fibrosis (HP:0002612)2.81049292
31Enlarged kidneys (HP:0000105)2.80917584
32Aplasia/Hypoplasia of the sacrum (HP:0008517)2.79845365
33Abnormality of the carotid arteries (HP:0005344)2.71907266
34Abnormality of the ileum (HP:0001549)2.71595451
35Abnormality of midbrain morphology (HP:0002418)2.71475744
36Molar tooth sign on MRI (HP:0002419)2.71475744
37Abnormality of the renal collecting system (HP:0004742)2.71005983
38Overriding aorta (HP:0002623)2.68973571
39Macrocytic anemia (HP:0001972)2.63313095
40Oligodactyly (HP:0012165)2.60303680
41Abnormality of the preputium (HP:0100587)2.56831619
42Horseshoe kidney (HP:0000085)2.56630386
43Anophthalmia (HP:0000528)2.54907016
44Abnormal number of incisors (HP:0011064)2.53863117
45Abnormality of the renal cortex (HP:0011035)2.53397517
46Potter facies (HP:0002009)2.49225247
47Facial shape deformation (HP:0011334)2.49225247
48Pallor (HP:0000980)2.49125003
49Stenosis of the external auditory canal (HP:0000402)2.47159649
50Renovascular hypertension (HP:0100817)2.45042629
51Tubulointerstitial abnormality (HP:0001969)2.45004954
52True hermaphroditism (HP:0010459)2.42736630
53Renal duplication (HP:0000075)2.42585585
54Nephronophthisis (HP:0000090)2.40359269
55Abnormality of the diencephalon (HP:0010662)2.39821996
56Medial flaring of the eyebrow (HP:0010747)2.38895160
57Renal Fanconi syndrome (HP:0001994)2.37141324
58Optic nerve hypoplasia (HP:0000609)2.35568465
59Abnormality of chromosome stability (HP:0003220)2.29300994
60Absent radius (HP:0003974)2.28459408
61Flat cornea (HP:0007720)2.22967159
62Intestinal atresia (HP:0011100)2.19659730
63Abnormal number of erythroid precursors (HP:0012131)2.19501716
64Triphalangeal thumb (HP:0001199)2.19491592
65Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.17465968
66Absent forearm bone (HP:0003953)2.14409438
67Aplasia involving forearm bones (HP:0009822)2.14409438
68Renal dysplasia (HP:0000110)2.12739220
69Gait imbalance (HP:0002141)2.08107656
70Congenital primary aphakia (HP:0007707)2.07188738
71Breast hypoplasia (HP:0003187)2.07183538
72Hypoplastic female external genitalia (HP:0012815)2.05947489
73Abnormality of DNA repair (HP:0003254)2.05144710
74Absent septum pellucidum (HP:0001331)2.04172962
75Tracheoesophageal fistula (HP:0002575)2.03333628
76Colon cancer (HP:0003003)2.02720676
77Abnormality of the labia minora (HP:0012880)2.02462320
7811 pairs of ribs (HP:0000878)2.02320430
79Polyuria (HP:0000103)1.97828500
80Volvulus (HP:0002580)1.96863644
81Abdominal situs inversus (HP:0003363)1.96100018
82Abnormality of abdominal situs (HP:0011620)1.96100018
83Diastasis recti (HP:0001540)1.95032931
84Esophageal atresia (HP:0002032)1.93492952
85Exertional dyspnea (HP:0002875)1.93467540
86Hyperacusis (HP:0010780)1.90373077
87Sclerocornea (HP:0000647)1.89606773
88Chronic hepatic failure (HP:0100626)1.87379554
89Increased intramyocellular lipid droplets (HP:0012240)1.85893398
90Hyperphosphaturia (HP:0003109)1.85063954
91Broad-based gait (HP:0002136)1.84253774
92Labial hypoplasia (HP:0000066)1.83945081
93Nephrogenic diabetes insipidus (HP:0009806)1.82091673
94Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.80939608
95Short thumb (HP:0009778)1.80759547
96Male pseudohermaphroditism (HP:0000037)1.80079020
97Abnormality of the duodenum (HP:0002246)1.78876880
98Protruding tongue (HP:0010808)1.78553971
99Astigmatism (HP:0000483)1.77805341
100Mitochondrial inheritance (HP:0001427)1.76989286

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM285.92156905
2CDC73.18856891
3CASK3.08469205
4EPHB23.01607554
5MKNK23.00911706
6DYRK22.82775575
7FRK2.17449280
8TAF12.08427376
9TNIK2.05829977
10WEE12.03789102
11PASK1.98785143
12WNK31.94493348
13ADRBK21.92681551
14CDK191.92300626
15MAP4K21.91527898
16ALK1.74710894
17PIK3CA1.71056605
18EPHA31.52891401
19MKNK11.50578215
20GRK11.40915980
21MAP3K41.32132270
22PRKCH1.31657648
23PNCK1.28292461
24SGK4941.26451908
25SGK2231.26451908
26CHEK11.23098019
27CCNB11.22412150
28BRSK21.16651452
29PLK41.16146167
30BMPR1B1.14149696
31ATR1.08285928
32DYRK30.99456164
33MAPK150.98383321
34PLK10.98151047
35CAMK1G0.97554086
36NME10.97295238
37BCKDK0.96865896
38PAK30.94500890
39TIE10.94261764
40MAP2K70.93020725
41INSRR0.92647911
42PRKCG0.92174908
43ZAK0.87199318
44TLK10.85383722
45CHEK20.84707968
46MARK10.83216893
47STK160.81806864
48WNK40.79325666
49AURKB0.78792165
50OXSR10.78174573
51BCR0.74230076
52VRK10.73549183
53MST1R0.73207536
54TGFBR10.72312839
55STK110.69777016
56GRK70.69768727
57NEK10.69332853
58CAMK1D0.68896272
59CSNK1E0.66283256
60PLK30.65406315
61NUAK10.64363423
62ATM0.64120400
63CDK30.63810197
64TYRO30.61371398
65MINK10.61092015
66NLK0.59757563
67LRRK20.59481421
68EPHA20.58138701
69SGK20.55585338
70BRAF0.55380407
71NTRK30.54095201
72IRAK20.51978956
73CAMK10.51545260
74MAPK130.51009879
75BRSK10.50554712
76MAPK140.48858349
77CDK10.48728958
78NEK20.47139894
79ERBB20.46807567
80AKT10.46346271
81MAP3K90.46027782
82IRAK10.45474609
83MARK30.44980373
84ADRBK10.44970330
85ERBB40.44864324
86PRKACA0.44729998
87PRKDC0.42365463
88DAPK30.41669469
89PRKCE0.40356524
90DYRK1A0.39756149
91ACVR1B0.39123439
92FGFR10.38322535
93CDK20.37998790
94STK38L0.37463307
95CSNK2A20.36549543
96TTK0.35720341
97OBSCN0.35438780
98GSK3B0.33867725
99PRKG10.32691359
100PRKCI0.31320232

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.87688286
2Oxidative phosphorylation_Homo sapiens_hsa001903.62112140
3Parkinsons disease_Homo sapiens_hsa050123.12979226
4Fanconi anemia pathway_Homo sapiens_hsa034603.11186625
5DNA replication_Homo sapiens_hsa030302.81731136
6Cardiac muscle contraction_Homo sapiens_hsa042602.64599959
7Homologous recombination_Homo sapiens_hsa034402.46315310
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.38462610
9Huntingtons disease_Homo sapiens_hsa050162.37693615
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.24594638
11Basal transcription factors_Homo sapiens_hsa030222.13373550
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.07878657
13Mismatch repair_Homo sapiens_hsa034301.97172092
14Alzheimers disease_Homo sapiens_hsa050101.91137792
15RNA polymerase_Homo sapiens_hsa030201.82103895
16Basal cell carcinoma_Homo sapiens_hsa052171.76496561
17Folate biosynthesis_Homo sapiens_hsa007901.64212231
18RNA degradation_Homo sapiens_hsa030181.63938918
19One carbon pool by folate_Homo sapiens_hsa006701.60366889
20Phototransduction_Homo sapiens_hsa047441.55284414
21Non-homologous end-joining_Homo sapiens_hsa034501.53777828
22Hedgehog signaling pathway_Homo sapiens_hsa043401.48094555
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.45864492
24Glutathione metabolism_Homo sapiens_hsa004801.41952433
25Taste transduction_Homo sapiens_hsa047421.27868021
26Sulfur relay system_Homo sapiens_hsa041221.23880706
27Pyrimidine metabolism_Homo sapiens_hsa002401.22391068
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21593608
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.20992571
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20990530
31Nicotine addiction_Homo sapiens_hsa050331.19440077
32Linoleic acid metabolism_Homo sapiens_hsa005911.15641243
33Cell cycle_Homo sapiens_hsa041101.10015635
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04776614
35Ether lipid metabolism_Homo sapiens_hsa005651.03924552
36Chemical carcinogenesis_Homo sapiens_hsa052041.03805235
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00514719
38Maturity onset diabetes of the young_Homo sapiens_hsa049500.94547486
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93440243
40Nitrogen metabolism_Homo sapiens_hsa009100.91417154
41Proteasome_Homo sapiens_hsa030500.89573666
42Spliceosome_Homo sapiens_hsa030400.87675230
43Glutamatergic synapse_Homo sapiens_hsa047240.85683957
44RNA transport_Homo sapiens_hsa030130.85644554
45Axon guidance_Homo sapiens_hsa043600.83748501
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77450826
47Dorso-ventral axis formation_Homo sapiens_hsa043200.77361199
48Mineral absorption_Homo sapiens_hsa049780.76003528
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73951534
50Purine metabolism_Homo sapiens_hsa002300.73550063
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72136359
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71161395
53Nucleotide excision repair_Homo sapiens_hsa034200.69695698
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69561764
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66429997
56Insulin secretion_Homo sapiens_hsa049110.65925809
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.65321363
58Morphine addiction_Homo sapiens_hsa050320.65263906
59Cholinergic synapse_Homo sapiens_hsa047250.63660784
60Butanoate metabolism_Homo sapiens_hsa006500.60643094
61Hippo signaling pathway_Homo sapiens_hsa043900.59075657
62Olfactory transduction_Homo sapiens_hsa047400.57054928
63Peroxisome_Homo sapiens_hsa041460.55845782
64Melanogenesis_Homo sapiens_hsa049160.48322831
65Base excision repair_Homo sapiens_hsa034100.47977615
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47596723
67Notch signaling pathway_Homo sapiens_hsa043300.47200782
68Serotonergic synapse_Homo sapiens_hsa047260.46967621
69Vitamin digestion and absorption_Homo sapiens_hsa049770.44272159
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43800146
71Circadian rhythm_Homo sapiens_hsa047100.43548099
72Lysine degradation_Homo sapiens_hsa003100.43259982
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42112325
74p53 signaling pathway_Homo sapiens_hsa041150.42010651
75Ovarian steroidogenesis_Homo sapiens_hsa049130.41087318
76Wnt signaling pathway_Homo sapiens_hsa043100.40499128
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40382781
78Caffeine metabolism_Homo sapiens_hsa002320.39966515
79Sulfur metabolism_Homo sapiens_hsa009200.39952157
80Fat digestion and absorption_Homo sapiens_hsa049750.38394399
81Collecting duct acid secretion_Homo sapiens_hsa049660.37265959
82Bile secretion_Homo sapiens_hsa049760.36987762
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36456808
84MicroRNAs in cancer_Homo sapiens_hsa052060.34163904
85Propanoate metabolism_Homo sapiens_hsa006400.33778212
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33025691
87Dilated cardiomyopathy_Homo sapiens_hsa054140.31752406
88Glycerolipid metabolism_Homo sapiens_hsa005610.31603922
89Metabolic pathways_Homo sapiens_hsa011000.31455810
90Retinol metabolism_Homo sapiens_hsa008300.30255865
91Pathways in cancer_Homo sapiens_hsa052000.29380977
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.28954366
93Protein export_Homo sapiens_hsa030600.28580563
94GABAergic synapse_Homo sapiens_hsa047270.28532460
95Arachidonic acid metabolism_Homo sapiens_hsa005900.27903384
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.27169469
97African trypanosomiasis_Homo sapiens_hsa051430.23878575
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.23643960
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.22567620
100mRNA surveillance pathway_Homo sapiens_hsa030150.22090841

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