KLF4P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kinetochore organization (GO:0051383)5.23568340
2kinetochore assembly (GO:0051382)5.19502699
3regulation of nuclear cell cycle DNA replication (GO:0033262)4.94922459
4mitotic sister chromatid cohesion (GO:0007064)4.89509154
5anterograde synaptic vesicle transport (GO:0048490)4.43028869
6fibroblast migration (GO:0010761)4.26128825
7regulation of telomere maintenance (GO:0032204)4.16453412
8DNA double-strand break processing (GO:0000729)4.11869909
9DNA replication checkpoint (GO:0000076)4.02862109
10negative regulation of protein localization to cell surface (GO:2000009)3.92834546
11N-terminal protein amino acid acetylation (GO:0006474)3.88708208
12oligosaccharide biosynthetic process (GO:0009312)3.87423869
13snRNA transcription (GO:0009301)3.86905040
14DNA topological change (GO:0006265)3.80690319
15negative regulation of smooth muscle cell differentiation (GO:0051151)3.76927768
16negative regulation of DNA-dependent DNA replication (GO:2000104)3.70492191
17meiotic chromosome segregation (GO:0045132)3.64456913
18sister chromatid cohesion (GO:0007062)3.57212182
19regulation of translation, ncRNA-mediated (GO:0045974)3.44626457
20negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.44626457
21negative regulation of translation, ncRNA-mediated (GO:0040033)3.44626457
22chromatin remodeling at centromere (GO:0031055)3.44031551
23negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.42160701
24mitotic sister chromatid segregation (GO:0000070)3.40070411
25proteasome assembly (GO:0043248)3.33570277
26endocardial cushion development (GO:0003197)3.32460438
27DNA deamination (GO:0045006)3.27176269
28response to pheromone (GO:0019236)3.26334996
29reciprocal meiotic recombination (GO:0007131)3.25876258
30reciprocal DNA recombination (GO:0035825)3.25876258
31CENP-A containing nucleosome assembly (GO:0034080)3.23808461
32cysteine metabolic process (GO:0006534)3.20595492
33positive regulation of cell fate commitment (GO:0010455)3.19852608
34replication fork processing (GO:0031297)3.19201146
35spindle checkpoint (GO:0031577)3.16892123
36regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.16244477
37metaphase plate congression (GO:0051310)3.13040725
38histone exchange (GO:0043486)3.12753432
39ER overload response (GO:0006983)3.06452061
40negative regulation of chromosome segregation (GO:0051985)3.02646242
41negative regulation of mRNA processing (GO:0050686)3.02619848
42negative regulation of mitotic sister chromatid separation (GO:2000816)3.01614272
43negative regulation of sister chromatid segregation (GO:0033046)3.01614272
44negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.01614272
45negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.01614272
46negative regulation of mitotic sister chromatid segregation (GO:0033048)3.01614272
47regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.01100899
48mitotic spindle checkpoint (GO:0071174)2.98092715
49sister chromatid segregation (GO:0000819)2.96754000
50regulation of histone phosphorylation (GO:0033127)2.95870725
51negative regulation of mRNA metabolic process (GO:1903312)2.95607888
52negative regulation of cell cycle G2/M phase transition (GO:1902750)2.95266679
53positive regulation of dendritic spine morphogenesis (GO:0061003)2.94909747
54double-strand break repair via homologous recombination (GO:0000724)2.94556548
55histone mRNA catabolic process (GO:0071044)2.93976641
56mitotic spindle assembly checkpoint (GO:0007094)2.93530496
57inner cell mass cell proliferation (GO:0001833)2.91119235
58recombinational repair (GO:0000725)2.87343188
59spindle assembly checkpoint (GO:0071173)2.87005217
60nucleobase biosynthetic process (GO:0046112)2.86754793
61negative regulation of histone acetylation (GO:0035067)2.83115735
62tryptophan metabolic process (GO:0006568)2.82381473
63tryptophan catabolic process (GO:0006569)2.81602342
64indole-containing compound catabolic process (GO:0042436)2.81602342
65indolalkylamine catabolic process (GO:0046218)2.81602342
66oxidative demethylation (GO:0070989)2.79073512
67negative regulation of B cell apoptotic process (GO:0002903)2.76527556
68regulation of centriole replication (GO:0046599)2.76471558
69anterograde axon cargo transport (GO:0008089)2.75551699
70positive regulation of developmental pigmentation (GO:0048087)2.74092677
71regulation of telomere maintenance via telomerase (GO:0032210)2.72442323
72spermatid nucleus differentiation (GO:0007289)2.71571839
73regulation of pigment cell differentiation (GO:0050932)2.71133066
74microtubule depolymerization (GO:0007019)2.70624458
75regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.70535665
76regulation of mitotic spindle checkpoint (GO:1903504)2.70535665
77establishment of chromosome localization (GO:0051303)2.68959276
78regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.68726575
79negative regulation of peptidyl-lysine acetylation (GO:2000757)2.68199963
80positive regulation of fatty acid beta-oxidation (GO:0032000)2.67159743
81attachment of spindle microtubules to kinetochore (GO:0008608)2.66666755
82monoubiquitinated protein deubiquitination (GO:0035520)2.66389211
83glucocorticoid receptor signaling pathway (GO:0042921)2.65859829
84negative regulation of cell division (GO:0051782)2.65546047
85hindbrain development (GO:0030902)2.64786823
86mitotic chromosome condensation (GO:0007076)2.64431139
87regulation of mitotic metaphase/anaphase transition (GO:0030071)2.63833144
88regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.63833144
89regulation of cell proliferation involved in kidney development (GO:1901722)2.63512898
90mitotic metaphase plate congression (GO:0007080)2.62613795
91negative regulation of telomere maintenance (GO:0032205)2.62450007
92regulation of hippo signaling (GO:0035330)2.62429414
93transcription from mitochondrial promoter (GO:0006390)2.62247479
94kynurenine metabolic process (GO:0070189)2.62004477
95glomerular visceral epithelial cell development (GO:0072015)2.61184333
96inositol phosphate catabolic process (GO:0071545)2.61087919
97negative regulation of sodium ion transport (GO:0010766)2.60744885
98regulation of mitotic sister chromatid separation (GO:0010965)2.60354921
99regulation of mitotic sister chromatid segregation (GO:0033047)2.60354921
100regulation of sister chromatid segregation (GO:0033045)2.60354921

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.56323434
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.08302369
3VDR_22108803_ChIP-Seq_LS180_Human3.36799398
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.36443871
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.24246581
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.23306461
7NOTCH1_21737748_ChIP-Seq_TLL_Human2.88845666
8ZNF274_21170338_ChIP-Seq_K562_Hela2.82996232
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.77386004
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74937340
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.69638623
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.61843546
13E2F7_22180533_ChIP-Seq_HELA_Human2.58495118
14EWS_26573619_Chip-Seq_HEK293_Human2.43583733
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.39346974
16ELK1_19687146_ChIP-ChIP_HELA_Human2.35851632
17GBX2_23144817_ChIP-Seq_PC3_Human2.29085086
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.27835890
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25399895
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25053234
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.22028326
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.21739278
23FUS_26573619_Chip-Seq_HEK293_Human1.87809864
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.80735355
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77016498
26CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.76965988
27TP53_16413492_ChIP-PET_HCT116_Human1.75710096
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75057108
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.71875047
30P300_19829295_ChIP-Seq_ESCs_Human1.71258101
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71163314
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.68246002
33MYC_18940864_ChIP-ChIP_HL60_Human1.68206019
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.64605380
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58376296
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55223270
37VDR_23849224_ChIP-Seq_CD4+_Human1.51929884
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.49304875
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.49046958
40ER_23166858_ChIP-Seq_MCF-7_Human1.45409457
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42864133
42TAF15_26573619_Chip-Seq_HEK293_Human1.42424795
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42221353
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40572365
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40505886
46GATA1_22025678_ChIP-Seq_K562_Human1.38214262
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.37510557
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35680501
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.33898969
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32354736
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31106536
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.30946349
53AR_21572438_ChIP-Seq_LNCaP_Human1.29849092
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27114640
55FOXM1_26456572_ChIP-Seq_MCF-7_Human1.25041483
56CBP_20019798_ChIP-Seq_JUKART_Human1.24915118
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24915118
58STAT3_23295773_ChIP-Seq_U87_Human1.24096078
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23613175
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23008590
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18239625
62SMAD4_21799915_ChIP-Seq_A2780_Human1.16885358
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16751207
64CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15799467
65MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13598268
66FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.13047554
67AR_21909140_ChIP-Seq_LNCAP_Human1.13013510
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12837171
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12479838
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12443039
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10500548
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08787885
73BRD4_25478319_ChIP-Seq_HGPS_Human1.08689036
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06912509
75AR_25329375_ChIP-Seq_VCAP_Human1.06663175
76CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05915122
77NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05511610
78PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04559933
79SOX2_19829295_ChIP-Seq_ESCs_Human1.03137486
80NANOG_19829295_ChIP-Seq_ESCs_Human1.03137486
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03016693
82SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01959416
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00588688
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99829790
85TP53_18474530_ChIP-ChIP_U2OS_Human0.99560091
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98678153
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97849987
88ETV1_20927104_ChIP-Seq_GIST48_Human0.96610559
89SRF_21415370_ChIP-Seq_HL-1_Mouse0.94868082
90CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94755560
91NFE2_27457419_Chip-Seq_LIVER_Mouse0.94578046
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94476432
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94242313
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93667435
95SMAD4_21741376_ChIP-Seq_EPCs_Human0.93044186
96PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.92601364
97CJUN_26792858_Chip-Seq_BT549_Human0.92406780
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91893803
99FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91427852
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90596494

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.61153220
2MP0003646_muscle_fatigue5.08009142
3MP0003136_yellow_coat_color3.45234894
4MP0006292_abnormal_olfactory_placode3.16214174
5MP0010094_abnormal_chromosome_stability2.97966441
6MP0003195_calcinosis2.79276075
7MP0002332_abnormal_exercise_endurance2.64286581
8MP0003950_abnormal_plasma_membrane2.45254970
9MP0004043_abnormal_pH_regulation2.38390956
10MP0003111_abnormal_nucleus_morphology2.31967170
11MP0003718_maternal_effect2.30656378
12MP0003890_abnormal_embryonic-extraembry2.22555895
13MP0003786_premature_aging2.22107184
14MP0008007_abnormal_cellular_replicative1.95932458
15MP0003077_abnormal_cell_cycle1.92600795
16MP0008058_abnormal_DNA_repair1.84103306
17MP0003937_abnormal_limbs/digits/tail_de1.82526716
18MP0005266_abnormal_metabolism1.76852201
19MP0000569_abnormal_digit_pigmentation1.74591889
20MP0003693_abnormal_embryo_hatching1.70599583
21MP0003941_abnormal_skin_development1.68591947
22MP0000372_irregular_coat_pigmentation1.67403139
23MP0009697_abnormal_copulation1.64731127
24MP0006035_abnormal_mitochondrial_morpho1.63397015
25MP0005083_abnormal_biliary_tract1.60322114
26MP0001293_anophthalmia1.57800720
27MP0004957_abnormal_blastocyst_morpholog1.56131729
28MP0008995_early_reproductive_senescence1.56117027
29MP0000015_abnormal_ear_pigmentation1.55486449
30MP0002938_white_spotting1.55229618
31MP0004147_increased_porphyrin_level1.54999924
32MP0005084_abnormal_gallbladder_morpholo1.53204368
33MP0005386_behavior/neurological_phenoty1.44835058
34MP0004924_abnormal_behavior1.44835058
35MP0008932_abnormal_embryonic_tissue1.37561745
36MP0006036_abnormal_mitochondrial_physio1.36320865
37MP0004133_heterotaxia1.36152568
38MP0008961_abnormal_basal_metabolism1.31913571
39MP0005174_abnormal_tail_pigmentation1.30328028
40MP0003755_abnormal_palate_morphology1.27510311
41MP0000749_muscle_degeneration1.24375556
42MP0000579_abnormal_nail_morphology1.23900846
43MP0002234_abnormal_pharynx_morphology1.22679793
44MP0001929_abnormal_gametogenesis1.21941756
45MP0005395_other_phenotype1.18801576
46MP0000427_abnormal_hair_cycle1.16537715
47MP0005075_abnormal_melanosome_morpholog1.16453121
48MP0001188_hyperpigmentation1.15937729
49MP0001529_abnormal_vocalization1.13776807
50MP0000358_abnormal_cell_content/1.05874692
51MP0003186_abnormal_redox_activity1.04605226
52MP0004215_abnormal_myocardial_fiber1.04602808
53MP0000647_abnormal_sebaceous_gland1.03896902
54MP0002095_abnormal_skin_pigmentation1.00408716
55MP0004808_abnormal_hematopoietic_stem0.99564764
56MP0004130_abnormal_muscle_cell0.99239621
57MP0005253_abnormal_eye_physiology0.98728446
58MP0002736_abnormal_nociception_after0.97847278
59MP0000371_diluted_coat_color0.92657457
60MP0002396_abnormal_hematopoietic_system0.91626669
61MP0001968_abnormal_touch/_nociception0.89932225
62MP0002277_abnormal_respiratory_mucosa0.87204884
63MP0001324_abnormal_eye_pigmentation0.87107607
64MP0000538_abnormal_urinary_bladder0.86139502
65MP0002210_abnormal_sex_determination0.84051027
66MP0002653_abnormal_ependyma_morphology0.83414092
67MP0009046_muscle_twitch0.82834672
68MP0004142_abnormal_muscle_tone0.81904186
69MP0001697_abnormal_embryo_size0.80979268
70MP0001145_abnormal_male_reproductive0.80789610
71MP0002837_dystrophic_cardiac_calcinosis0.79832540
72MP0000653_abnormal_sex_gland0.79663805
73MP0009384_cardiac_valve_regurgitation0.79283444
74MP0001501_abnormal_sleep_pattern0.78255419
75MP0002102_abnormal_ear_morphology0.78054460
76MP0004381_abnormal_hair_follicle0.77960373
77MP0002269_muscular_atrophy0.77612126
78MP0003567_abnormal_fetal_cardiomyocyte0.77378125
79MP0005220_abnormal_exocrine_pancreas0.75947660
80MP0003698_abnormal_male_reproductive0.75857763
81MP0005187_abnormal_penis_morphology0.75129324
82MP0000049_abnormal_middle_ear0.74582569
83MP0003137_abnormal_impulse_conducting0.74046918
84MP0002970_abnormal_white_adipose0.71824966
85MP0000383_abnormal_hair_follicle0.71752316
86MP0001672_abnormal_embryogenesis/_devel0.71581950
87MP0005380_embryogenesis_phenotype0.71581950
88MP0001764_abnormal_homeostasis0.71004735
89MP0005076_abnormal_cell_differentiation0.70407577
90MP0001286_abnormal_eye_development0.69184941
91MP0002751_abnormal_autonomic_nervous0.69152464
92MP0009115_abnormal_fat_cell0.65899050
93MP0005376_homeostasis/metabolism_phenot0.64735791
94MP0002085_abnormal_embryonic_tissue0.64193532
95MP0002168_other_aberrant_phenotype0.63833126
96MP0004145_abnormal_muscle_electrophysio0.62732439
97MP0001873_stomach_inflammation0.62637979
98MP0002971_abnormal_brown_adipose0.62630538
99MP0003935_abnormal_craniofacial_develop0.62573627
100MP0002084_abnormal_developmental_patter0.60917130

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.12564851
2Protruding tongue (HP:0010808)4.88454887
3Sensory axonal neuropathy (HP:0003390)4.72955255
4Volvulus (HP:0002580)4.08535811
5Aplasia/Hypoplasia of the tibia (HP:0005772)3.70571742
6Abnormality of midbrain morphology (HP:0002418)3.61341059
7Molar tooth sign on MRI (HP:0002419)3.61341059
8Patellar aplasia (HP:0006443)3.49946329
9Chronic hepatic failure (HP:0100626)3.36393348
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.14052865
11Abnormality of the ileum (HP:0001549)3.11563424
12Aplasia/Hypoplasia of the patella (HP:0006498)3.11486697
13Meckel diverticulum (HP:0002245)3.10092883
14Pancreatic cysts (HP:0001737)3.09003891
15True hermaphroditism (HP:0010459)3.08188200
16Febrile seizures (HP:0002373)2.99308063
17Abnormality of chromosome stability (HP:0003220)2.96229904
18Pancreatic fibrosis (HP:0100732)2.96092312
19Long clavicles (HP:0000890)2.95026865
20Absent radius (HP:0003974)2.84717743
21Hyperventilation (HP:0002883)2.79211583
22Preaxial hand polydactyly (HP:0001177)2.73655255
23Clubbing of toes (HP:0100760)2.70061480
24Absent forearm bone (HP:0003953)2.66086859
25Aplasia involving forearm bones (HP:0009822)2.66086859
26Sloping forehead (HP:0000340)2.65613521
27Small intestinal stenosis (HP:0012848)2.58243490
28Duodenal stenosis (HP:0100867)2.58243490
29Abnormality of the labia majora (HP:0012881)2.57992579
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.56141183
31Neonatal respiratory distress (HP:0002643)2.56117881
32Clumsiness (HP:0002312)2.55331635
33Chromsome breakage (HP:0040012)2.52393162
34Abnormality of the preputium (HP:0100587)2.50805073
35Hypoplastic labia majora (HP:0000059)2.48756310
36Sclerocornea (HP:0000647)2.39818323
37Fair hair (HP:0002286)2.38679164
38Breast hypoplasia (HP:0003187)2.37019101
39Increased number of teeth (HP:0011069)2.35219096
40Abnormality of the duodenum (HP:0002246)2.34395141
41Abnormality of the labia minora (HP:0012880)2.34313057
42Small hand (HP:0200055)2.30552285
43Intestinal atresia (HP:0011100)2.30348997
44Optic nerve coloboma (HP:0000588)2.28180476
45Ectopic kidney (HP:0000086)2.26845786
46Aplasia/Hypoplasia of the tongue (HP:0010295)2.26072424
47Triphalangeal thumb (HP:0001199)2.24542400
48Genetic anticipation (HP:0003743)2.23016648
49Broad-based gait (HP:0002136)2.22104158
50Absent thumb (HP:0009777)2.16652428
51Nephronophthisis (HP:0000090)2.16078692
52Tubular atrophy (HP:0000092)2.12936227
53Hypoplastic iliac wings (HP:0002866)2.08680670
54Preaxial foot polydactyly (HP:0001841)2.07054353
55Abnormality of the carotid arteries (HP:0005344)2.06392788
56Highly arched eyebrow (HP:0002553)2.05809770
57Anencephaly (HP:0002323)2.05036424
58Acute myeloid leukemia (HP:0004808)2.04808316
59Duplicated collecting system (HP:0000081)2.03510364
60Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.02008255
61Microtia (HP:0008551)2.00344364
62Progressive inability to walk (HP:0002505)2.00200070
63Abnormality of the pons (HP:0007361)1.98835235
64Abnormality of the renal medulla (HP:0100957)1.98012195
65Stomach cancer (HP:0012126)1.96768438
66Abnormality of the renal cortex (HP:0011035)1.95952693
67Concave nail (HP:0001598)1.91897100
68Type I transferrin isoform profile (HP:0003642)1.91831363
69Astigmatism (HP:0000483)1.91716829
70Esophageal atresia (HP:0002032)1.91364439
71Labial hypoplasia (HP:0000066)1.90638773
72Short thumb (HP:0009778)1.90518632
73Congenital stationary night blindness (HP:0007642)1.89170800
74Hypoplastic female external genitalia (HP:0012815)1.87353219
75Bile duct proliferation (HP:0001408)1.85325663
76Abnormal biliary tract physiology (HP:0012439)1.85325663
77Gastrointestinal atresia (HP:0002589)1.84557753
78Abnormal lung lobation (HP:0002101)1.84520873
79Lissencephaly (HP:0001339)1.83694514
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.83490314
81Cystic liver disease (HP:0006706)1.80408049
82Abnormality of the septum pellucidum (HP:0007375)1.80371371
83Dandy-Walker malformation (HP:0001305)1.80077411
84Congenital hepatic fibrosis (HP:0002612)1.80052809
85Visual hallucinations (HP:0002367)1.77986698
86Abnormality of the parathyroid morphology (HP:0011766)1.77221789
87Thin upper lip vermilion (HP:0000219)1.76464124
88Furrowed tongue (HP:0000221)1.75609137
89Embryonal renal neoplasm (HP:0011794)1.73787542
90Absent septum pellucidum (HP:0001331)1.73395010
91Oligodactyly (hands) (HP:0001180)1.73209260
92Myelodysplasia (HP:0002863)1.71023374
93Pancreatic islet-cell hyperplasia (HP:0004510)1.70010549
94Broad foot (HP:0001769)1.69924921
95Hypoplasia of the pons (HP:0012110)1.69418782
96Postaxial foot polydactyly (HP:0001830)1.69239075
97Generalized hypopigmentation of hair (HP:0011358)1.69208283
98Generalized tonic-clonic seizures (HP:0002069)1.68907852
99Gaze-evoked nystagmus (HP:0000640)1.68390657
100Congenital primary aphakia (HP:0007707)1.67687495

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.01834298
2MKNK24.55182576
3BUB13.83004193
4INSRR3.73328043
5BRSK23.15789993
6MKNK12.92795417
7ACVR1B2.35337998
8ERBB32.29629581
9TRIM282.26094696
10ZAK2.06516510
11WEE11.96370795
12MAP3K121.92552240
13BMPR1B1.81582413
14WNK31.78341241
15TNIK1.75268923
16PIM21.71238606
17CASK1.59872499
18PLK41.56087921
19PLK21.50439975
20CLK11.46021392
21EIF2AK31.33928885
22NUAK11.31919788
23EPHA41.28266819
24TGFBR11.27771545
25TRPM71.27658632
26BCR1.26756651
27MAP3K101.25759226
28ADRBK11.20957889
29PLK31.14837758
30SRPK11.14818480
31STK391.14748655
32SIK31.14388678
33MST41.13953697
34GRK11.10836800
35CDK121.08099977
36NEK11.07982492
37MYLK0.99040208
38KSR10.97333761
39TTK0.95668656
40PLK10.94541264
41MAPK130.94406759
42CAMK1D0.92782941
43MOS0.91026850
44ADRBK20.90513483
45PTK2B0.87994872
46WNK40.85299752
47RAF10.82189921
48AURKB0.79531459
49VRK10.79112910
50ATR0.78853155
51EIF2AK20.78730464
52STK38L0.74658724
53PDK20.73954446
54NEK20.73529196
55CAMK1G0.71846990
56MARK30.68819338
57OBSCN0.67875513
58TEC0.65988334
59CDC70.65611466
60CHEK20.64573216
61GRK70.63502563
62PIM10.61818385
63BRSK10.61598803
64RPS6KA50.60225110
65CSNK1G10.60167841
66ATM0.55647086
67STK40.54951577
68CDK30.53751696
69MUSK0.53079802
70PAK30.51922995
71TGFBR20.51416237
72ERBB40.51319608
73PAK60.50424470
74IKBKB0.48753351
75MAPK110.48266176
76CHEK10.48210309
77DYRK30.47093285
78OXSR10.47017145
79MELK0.46837858
80NLK0.46692396
81TSSK60.45927818
82RPS6KA40.45398908
83PKN10.45016133
84PRKAA10.42535953
85CSNK1A1L0.42139201
86CHUK0.42006941
87PAK20.41670326
88NME10.39218342
89STK100.38591322
90VRK20.38555061
91CDK10.36563601
92ILK0.34105154
93TLK10.33768550
94GSK3A0.30966260
95CSNK1G30.30588566
96PIK3CA0.30423520
97MAPK100.29681514
98CSNK1G20.28043258
99FGFR10.27568099
100CDK20.26989562

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.50485872
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.28097976
3Vitamin B6 metabolism_Homo sapiens_hsa007503.25752659
4Fanconi anemia pathway_Homo sapiens_hsa034603.12154083
5Selenocompound metabolism_Homo sapiens_hsa004502.90699815
6Cell cycle_Homo sapiens_hsa041102.83757837
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.81384362
8One carbon pool by folate_Homo sapiens_hsa006702.76013253
9Non-homologous end-joining_Homo sapiens_hsa034502.48953856
10RNA polymerase_Homo sapiens_hsa030202.43940356
11RNA degradation_Homo sapiens_hsa030182.28187508
12Regulation of autophagy_Homo sapiens_hsa041402.25820342
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.00735981
14RNA transport_Homo sapiens_hsa030131.94877434
15Steroid biosynthesis_Homo sapiens_hsa001001.93412168
16Butanoate metabolism_Homo sapiens_hsa006501.82535242
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.81467940
18Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.76261894
19TGF-beta signaling pathway_Homo sapiens_hsa043501.71470631
20Proteasome_Homo sapiens_hsa030501.65465121
21Protein export_Homo sapiens_hsa030601.61939048
22mRNA surveillance pathway_Homo sapiens_hsa030151.60715274
23Basal transcription factors_Homo sapiens_hsa030221.58339579
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.58242465
25Olfactory transduction_Homo sapiens_hsa047401.57030976
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49107570
27Spliceosome_Homo sapiens_hsa030401.36934854
28Lysine degradation_Homo sapiens_hsa003101.33262788
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.30105401
30Systemic lupus erythematosus_Homo sapiens_hsa053221.25322777
31p53 signaling pathway_Homo sapiens_hsa041151.22080552
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19903127
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15847343
34Pyrimidine metabolism_Homo sapiens_hsa002401.15136800
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15116184
36Oocyte meiosis_Homo sapiens_hsa041141.14892019
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12541366
38Fatty acid biosynthesis_Homo sapiens_hsa000611.10049203
39Linoleic acid metabolism_Homo sapiens_hsa005911.07776592
40Circadian rhythm_Homo sapiens_hsa047101.05385707
41Hippo signaling pathway_Homo sapiens_hsa043901.02834565
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01292084
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01001443
44Phototransduction_Homo sapiens_hsa047440.96889675
45DNA replication_Homo sapiens_hsa030300.93216038
46Alcoholism_Homo sapiens_hsa050340.93190957
47Retinol metabolism_Homo sapiens_hsa008300.93068659
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92526490
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89614225
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85944958
51Base excision repair_Homo sapiens_hsa034100.85248259
52Nitrogen metabolism_Homo sapiens_hsa009100.84483126
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82936793
54Propanoate metabolism_Homo sapiens_hsa006400.82530074
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81596080
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.80416523
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77832670
58Peroxisome_Homo sapiens_hsa041460.77608448
59Tryptophan metabolism_Homo sapiens_hsa003800.76674619
60Purine metabolism_Homo sapiens_hsa002300.73877467
61Chemical carcinogenesis_Homo sapiens_hsa052040.71931045
62Ether lipid metabolism_Homo sapiens_hsa005650.71882047
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70699636
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69151652
65Taste transduction_Homo sapiens_hsa047420.65889410
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65730401
67Sulfur relay system_Homo sapiens_hsa041220.64808499
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62850530
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59143801
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.57419374
71Glutathione metabolism_Homo sapiens_hsa004800.50426253
72Mismatch repair_Homo sapiens_hsa034300.49128765
73Nucleotide excision repair_Homo sapiens_hsa034200.45773151
74FoxO signaling pathway_Homo sapiens_hsa040680.45668440
75Pyruvate metabolism_Homo sapiens_hsa006200.45430440
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42898675
77Metabolic pathways_Homo sapiens_hsa011000.41338789
78Caffeine metabolism_Homo sapiens_hsa002320.41216862
79MicroRNAs in cancer_Homo sapiens_hsa052060.39858762
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34972395
81Nicotine addiction_Homo sapiens_hsa050330.31182668
82ABC transporters_Homo sapiens_hsa020100.30140032
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29994038
84TNF signaling pathway_Homo sapiens_hsa046680.29952519
85African trypanosomiasis_Homo sapiens_hsa051430.29883060
86Dopaminergic synapse_Homo sapiens_hsa047280.28762314
87Vitamin digestion and absorption_Homo sapiens_hsa049770.28282023
88Huntingtons disease_Homo sapiens_hsa050160.27874483
89Calcium signaling pathway_Homo sapiens_hsa040200.26161476
90Prostate cancer_Homo sapiens_hsa052150.25709575
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25327220
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22627952
93Viral carcinogenesis_Homo sapiens_hsa052030.20688871
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20681004
95Wnt signaling pathway_Homo sapiens_hsa043100.20504284
96Arginine and proline metabolism_Homo sapiens_hsa003300.16826499
97Starch and sucrose metabolism_Homo sapiens_hsa005000.14934228
98Glycerolipid metabolism_Homo sapiens_hsa005610.14578659
99Tight junction_Homo sapiens_hsa045300.13520289
100Fatty acid metabolism_Homo sapiens_hsa012120.13083986

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