KLF5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte proliferation (GO:0043616)6.03471562
2multicellular organismal water homeostasis (GO:0050891)5.87676174
3interferon-gamma secretion (GO:0072643)5.70086356
4keratinization (GO:0031424)5.54012689
5water homeostasis (GO:0030104)4.81833859
6trophectodermal cell differentiation (GO:0001829)4.76527901
7regulation of posttranscriptional gene silencing (GO:0060147)4.74879484
8regulation of gene silencing by miRNA (GO:0060964)4.74879484
9regulation of gene silencing by RNA (GO:0060966)4.74879484
10formation of translation preinitiation complex (GO:0001731)4.70782240
11keratinocyte differentiation (GO:0030216)4.70543179
12gap junction assembly (GO:0016264)4.26460520
13epidermal cell differentiation (GO:0009913)4.07059267
14regulation of cholesterol homeostasis (GO:2000188)3.97960150
15angiotensin maturation (GO:0002003)3.94693156
16maturation of SSU-rRNA (GO:0030490)3.92661019
17DNA deamination (GO:0045006)3.89287389
18* intestinal epithelial cell development (GO:0060576)3.85882689
19anterior/posterior axis specification, embryo (GO:0008595)3.85710276
20establishment of apical/basal cell polarity (GO:0035089)3.84179673
21regulation of keratinocyte differentiation (GO:0045616)3.83209869
22calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.80205674
23intermediate filament organization (GO:0045109)3.80145409
24intestinal absorption (GO:0050892)3.78286803
25ribosomal large subunit biogenesis (GO:0042273)3.77759991
26purine nucleobase biosynthetic process (GO:0009113)3.77518550
27regulation of keratinocyte proliferation (GO:0010837)3.72584168
28mitotic metaphase plate congression (GO:0007080)3.72550745
29labyrinthine layer development (GO:0060711)3.71527828
30epithelial cell-cell adhesion (GO:0090136)3.69988346
31regulation of water loss via skin (GO:0033561)3.69359631
32O-glycan processing (GO:0016266)3.58132859
33proline biosynthetic process (GO:0006561)3.57449677
34nucleobase biosynthetic process (GO:0046112)3.55735032
35ribosomal small subunit biogenesis (GO:0042274)3.54860156
36GDP-mannose metabolic process (GO:0019673)3.53367280
37regulation of hippo signaling (GO:0035330)3.51456201
38hemidesmosome assembly (GO:0031581)3.49726143
39epidermis development (GO:0008544)3.49173419
40folic acid metabolic process (GO:0046655)3.42559833
41ribonucleoprotein complex biogenesis (GO:0022613)3.41989607
42flavonoid metabolic process (GO:0009812)3.41092298
43positive regulation of Cdc42 GTPase activity (GO:0043089)3.40394307
44ribosome biogenesis (GO:0042254)3.40211051
45renal system process involved in regulation of blood volume (GO:0001977)3.39129727
46regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.37573186
47protein localization to kinetochore (GO:0034501)3.37311983
48regulation of nuclear cell cycle DNA replication (GO:0033262)3.33832260
49heterochromatin organization (GO:0070828)3.33474707
50viral transcription (GO:0019083)3.33179401
51mitotic sister chromatid segregation (GO:0000070)3.31988668
52translational initiation (GO:0006413)3.30069385
53establishment of skin barrier (GO:0061436)3.29196039
54ribosome assembly (GO:0042255)3.29097890
55histone H4-K12 acetylation (GO:0043983)3.28189471
56peptide cross-linking (GO:0018149)3.27910072
57somatic hypermutation of immunoglobulin genes (GO:0016446)3.27854603
58somatic diversification of immune receptors via somatic mutation (GO:0002566)3.27854603
59translational termination (GO:0006415)3.27720942
60transcription from mitochondrial promoter (GO:0006390)3.27395202
61cell-substrate junction assembly (GO:0007044)3.26343483
62DNA replication checkpoint (GO:0000076)3.26135743
63ventricular cardiac muscle cell action potential (GO:0086005)3.26067960
64establishment of planar polarity (GO:0001736)3.25978119
65establishment of tissue polarity (GO:0007164)3.25978119
66establishment of monopolar cell polarity (GO:0061162)3.24064726
67establishment or maintenance of monopolar cell polarity (GO:0061339)3.24064726
68primary alcohol catabolic process (GO:0034310)3.23939933
69cellular glucuronidation (GO:0052695)3.22345888
70positive regulation of pseudopodium assembly (GO:0031274)3.22011320
71pyrimidine-containing compound transmembrane transport (GO:0072531)3.21606872
72epithelial cell differentiation involved in prostate gland development (GO:0060742)3.20316649
73surfactant homeostasis (GO:0043129)3.20160416
74diterpenoid biosynthetic process (GO:0016102)3.17344291
75regulation of transforming growth factor beta2 production (GO:0032909)3.16904150
76renal filtration (GO:0097205)3.16621866
77keratinocyte development (GO:0003334)3.13711275
78regulation of transforming growth factor beta1 production (GO:0032908)3.12061770
79desmosome organization (GO:0002934)3.10250805
80regulation of vitamin metabolic process (GO:0030656)3.08357804
81regulation of translation in response to stress (GO:0043555)3.08196820
82replication fork processing (GO:0031297)3.07463702
83tight junction assembly (GO:0070830)3.05702817
84hypotonic response (GO:0006971)3.04596070
85negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.04136021
86lung-associated mesenchyme development (GO:0060484)3.00961811
87notochord development (GO:0030903)2.99246864
88mitotic nuclear envelope disassembly (GO:0007077)2.99023618
89uronic acid metabolic process (GO:0006063)2.98175252
90glucuronate metabolic process (GO:0019585)2.98175252
91negative regulation of epidermis development (GO:0045683)2.96687398
92metaphase plate congression (GO:0051310)2.96464500
93negative regulation of protein tyrosine kinase activity (GO:0061099)2.96236197
94cell differentiation involved in embryonic placenta development (GO:0060706)2.95544882
95vitamin transmembrane transport (GO:0035461)2.93093639
96phospholipid scrambling (GO:0017121)2.92814585
97maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.92672946
98rRNA processing (GO:0006364)2.92088319
99translational elongation (GO:0006414)2.92041172
100regulation of pseudopodium assembly (GO:0031272)2.91092691
101skin morphogenesis (GO:0043589)2.90984673
102regulation of cardioblast differentiation (GO:0051890)2.89227380
103cell-cell junction assembly (GO:0007043)2.89120892
104paraxial mesoderm development (GO:0048339)2.88656768
105DNA replication-dependent nucleosome organization (GO:0034723)2.88354106
106DNA replication-dependent nucleosome assembly (GO:0006335)2.88354106
107DNA replication initiation (GO:0006270)2.88055010
108regulation of epidermis development (GO:0045682)2.87611099
109regulation of guanylate cyclase activity (GO:0031282)2.87149417
110rRNA metabolic process (GO:0016072)2.86685575
111ethanol metabolic process (GO:0006067)2.86571259
112regulation of telomere maintenance via telomerase (GO:0032210)2.86158236
113folic acid transport (GO:0015884)2.85656284
114negative regulation of keratinocyte proliferation (GO:0010839)2.85132087
115axonemal dynein complex assembly (GO:0070286)2.84862877
116regulation of epidermal cell differentiation (GO:0045604)2.84385437
117rRNA modification (GO:0000154)2.83317220
118modified amino acid transport (GO:0072337)2.83305966
119nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.82996988
120determination of adult lifespan (GO:0008340)2.82740409
121regulation of double-strand break repair via homologous recombination (GO:0010569)2.80837571
122positive regulation of SMAD protein import into nucleus (GO:0060391)2.79518426
123bundle of His cell to Purkinje myocyte communication (GO:0086069)2.79273017
124negative regulation of epidermal cell differentiation (GO:0045605)2.78635683
125protein localization to chromosome, centromeric region (GO:0071459)2.77601487
126sphingomyelin metabolic process (GO:0006684)2.77502024
127nuclear envelope disassembly (GO:0051081)2.76948012
128membrane disassembly (GO:0030397)2.76948012
129branching involved in mammary gland duct morphogenesis (GO:0060444)2.76434276
130activation of Rac GTPase activity (GO:0032863)2.76396096
131auditory receptor cell differentiation (GO:0042491)2.75575499
132phosphatidylserine acyl-chain remodeling (GO:0036150)2.73750096
133pseudouridine synthesis (GO:0001522)2.72809676
134atrioventricular valve morphogenesis (GO:0003181)2.72433023
135DNA strand elongation involved in DNA replication (GO:0006271)2.72040151
136dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.71910516
137striated muscle atrophy (GO:0014891)2.71621230
138regulation of viral release from host cell (GO:1902186)2.71027795
139nuclear pore organization (GO:0006999)2.70720977
140antimicrobial humoral response (GO:0019730)2.70622293
141regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.70430783
142negative regulation of translational initiation (GO:0045947)2.70316103
143glomerular filtration (GO:0003094)2.70114131
144mitotic G1 DNA damage checkpoint (GO:0031571)2.70017812
145positive regulation of epidermal cell differentiation (GO:0045606)2.69431671
146mitochondrial DNA metabolic process (GO:0032042)2.68382507
147cellular protein complex disassembly (GO:0043624)2.67828189
148positive regulation of epidermis development (GO:0045684)2.67674476
149urea cycle (GO:0000050)2.67405288
150regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.66838588
151cytoskeletal anchoring at plasma membrane (GO:0007016)2.65863158
152regulation of translational fidelity (GO:0006450)2.65572606
153sister chromatid segregation (GO:0000819)2.65570833
154regulation of spindle organization (GO:0090224)2.64743413
155ribosomal small subunit assembly (GO:0000028)2.64433092
156excretion (GO:0007588)2.63205068
157branching involved in labyrinthine layer morphogenesis (GO:0060670)2.62978733
158viral life cycle (GO:0019058)2.62678808
159regulation of bile acid biosynthetic process (GO:0070857)2.62662123
160polarized epithelial cell differentiation (GO:0030859)2.62593494
161ethanol oxidation (GO:0006069)2.61769877
162protein K6-linked ubiquitination (GO:0085020)2.59161403
163cell fate commitment involved in formation of primary germ layer (GO:0060795)2.58977468
164citrulline biosynthetic process (GO:0019240)2.58395178
165apoptotic process involved in morphogenesis (GO:0060561)2.58250607
166nucleotide-sugar biosynthetic process (GO:0009226)2.57857159
167nodal signaling pathway (GO:0038092)2.57711552
168kinetochore assembly (GO:0051382)2.57464521
169maintenance of gastrointestinal epithelium (GO:0030277)2.57281287
170positive regulation of chromosome segregation (GO:0051984)2.57173281
171regulation of chemokine secretion (GO:0090196)2.56438712
172endosome organization (GO:0007032)2.55850739
173NADH metabolic process (GO:0006734)2.55090596
174epoxygenase P450 pathway (GO:0019373)2.50789353
175hair cycle (GO:0042633)2.47719535
176molting cycle (GO:0042303)2.47719535
177positive regulation of keratinocyte differentiation (GO:0045618)2.46941205
178antibacterial humoral response (GO:0019731)2.46278017
179chemical homeostasis within a tissue (GO:0048875)2.45855360
180morphogenesis of embryonic epithelium (GO:0016331)2.45628352
181regulation of metalloenzyme activity (GO:0048552)2.42930761
182urea metabolic process (GO:0019627)2.42269989
183renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.40363444
184oligosaccharide biosynthetic process (GO:0009312)2.40273817
185embryonic process involved in female pregnancy (GO:0060136)2.40242594
186receptor recycling (GO:0001881)2.39882065

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.90447037
2E2F7_22180533_ChIP-Seq_HELA_Human4.75779546
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.67093817
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.67093817
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.67093817
6* SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.63125588
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.39760315
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.96923773
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.93182810
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.92542024
11* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87717969
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.79274720
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.73336131
14NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.61423914
15* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.51198658
16NANOG_18555785_ChIP-Seq_MESCs_Mouse2.44501232
17TCF3_18692474_ChIP-Seq_MEFs_Mouse2.43182558
18FOXO3_23340844_ChIP-Seq_DLD1_Human2.40923089
19SOX2_20726797_ChIP-Seq_SW620_Human2.38132007
20ESR1_21235772_ChIP-Seq_MCF-7_Human2.36973850
21SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.35843329
22SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.35843329
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.34786314
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31200634
25* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.29814093
26* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25704403
27TRIM28_21343339_ChIP-Seq_HEK293_Human2.24889263
28RARG_19884340_ChIP-ChIP_MEFs_Mouse2.23331939
29PPAR_26484153_Chip-Seq_NCI-H1993_Human2.21978151
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.21392096
31STAT3_1855785_ChIP-Seq_MESCs_Mouse2.20369414
32* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18400057
33TCF3_18692474_ChIP-Seq_MESCs_Mouse2.07311500
34NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.04955197
35SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.03907015
36* GATA4_25053715_ChIP-Seq_YYC3_Human2.03062433
37E2F4_17652178_ChIP-ChIP_JURKAT_Human2.01462380
38ZNF263_19887448_ChIP-Seq_K562_Human2.00905412
39SOX9_24532713_ChIP-Seq_HFSC_Mouse1.99775473
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.95494486
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.91299837
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.87849748
43KLF5_25053715_ChIP-Seq_YYC3_Human1.86447452
44ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.84829050
45ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.84007670
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.83911289
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83018380
48AR_21909140_ChIP-Seq_LNCAP_Human1.80369175
49* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.79805578
50* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.78549639
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78102947
52* RUNX1_27514584_Chip-Seq_MCF-7_Human1.77992308
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77626828
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.76314509
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.71763600
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71682798
57* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.70724297
58FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.68307688
59* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.67672742
60CLOCK_20551151_ChIP-Seq_293T_Human1.65911804
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65068552
62* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65017073
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62341257
64* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60196670
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.57997276
66* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57975231
67NANOG_18692474_ChIP-Seq_MEFs_Mouse1.57821406
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.57770852
69XRN2_22483619_ChIP-Seq_HELA_Human1.57349343
70SOX2_18692474_ChIP-Seq_MEFs_Mouse1.55960335
71NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.54808731
72TP63_23658742_ChIP-Seq_EP156T_Human1.51951837
73* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.51357399
74EST1_17652178_ChIP-ChIP_JURKAT_Human1.49798728
75* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.49621727
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.49085385
77KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47595388
78POU5F1_16518401_ChIP-PET_MESCs_Mouse1.43397133
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.42533825
80NANOG_18692474_ChIP-Seq_MESCs_Mouse1.42348947
81GATA3_24758297_ChIP-Seq_MCF-7_Human1.42157680
82* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42102545
83PPARA_22158963_ChIP-Seq_LIVER_Mouse1.41743945
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40222413
85RXR_22158963_ChIP-Seq_LIVER_Mouse1.40098281
86GABP_17652178_ChIP-ChIP_JURKAT_Human1.39150693
87SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38917823
88SALL1_21062744_ChIP-ChIP_HESCs_Human1.38095270
89CDX2_20551321_ChIP-Seq_CACO-2_Human1.37104186
90ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36443769
91FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.34562564
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.34445593
93* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34386100
94SOX2_18692474_ChIP-Seq_MESCs_Mouse1.34155359
95MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33937730
96* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.33518945
97NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33329278
98LXR_22158963_ChIP-Seq_LIVER_Mouse1.29126516
99TP63_22573176_ChIP-Seq_HFKS_Human1.29004334
100ATF3_27146783_Chip-Seq_COLON_Human1.27394767
101* NANOG_21062744_ChIP-ChIP_HESCs_Human1.27260343
102* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.24441605
103* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.23134230
104TP63_19390658_ChIP-ChIP_HaCaT_Human1.22833965
105DCP1A_22483619_ChIP-Seq_HELA_Human1.22720846
106AHR_22903824_ChIP-Seq_MCF-7_Human1.21999772
107UBF1/2_26484160_Chip-Seq_HMECs_Human1.20455509
108ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.20392828
109TTF2_22483619_ChIP-Seq_HELA_Human1.20048555
110* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.19328279
111TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.19000006
112PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18564709
113KAP1_27257070_Chip-Seq_ESCs_Mouse1.17735687
114CJUN_26792858_Chip-Seq_BT549_Human1.17559885
115LXR_22292898_ChIP-Seq_THP-1_Human1.17300891
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15249004
117* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14624528
118E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14248603
119DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14089345
120* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13714293
121GABP_19822575_ChIP-Seq_HepG2_Human1.12010486
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11868375
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11471648
124KDM5A_27292631_Chip-Seq_BREAST_Human1.11267083
125ELK3_25401928_ChIP-Seq_HUVEC_Human1.11224163
126VDR_23849224_ChIP-Seq_CD4+_Human1.10028685
127* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08767656
128* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08504122
129* GATA6_25053715_ChIP-Seq_YYC3_Human1.07516908
130RACK7_27058665_Chip-Seq_MCF-7_Human1.07449035
131ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07430736
132NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05209505
133HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05147394
134HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04379866
135TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03571710
136GATA2_21666600_ChIP-Seq_HMVEC_Human1.03161376
137* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.03134516
138CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02960788
139* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02504268
140E2F1_21310950_ChIP-Seq_MCF-7_Human1.00897098
141ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97438598
142CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96944286
143* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96590968
144* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96105099
145PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94456927
146KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94084278
147RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93990494
148FOXA1_25552417_ChIP-Seq_VCAP_Human0.93847474
149THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92094286
150CREB1_26743006_Chip-Seq_LNCaP_Human0.91742137
151* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90337973
152TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.90000520
153BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.89434311
154* NANOG_16518401_ChIP-PET_MESCs_Mouse0.89234979
155TBX20_22328084_ChIP-Seq_HEART_Mouse0.89097124
156TBX20_22080862_ChIP-Seq_HEART_Mouse0.89097124
157ELK1_22589737_ChIP-Seq_MCF10A_Human0.86650442
158EGR1_19374776_ChIP-ChIP_THP-1_Human0.86597339
159* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86157087
160PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85741161
161RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.84970196
162CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84877352
163ARNT_22903824_ChIP-Seq_MCF-7_Human0.84680815
164JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84605137
165POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.84112947
166Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82595098
167IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.82317125
168* FOXA2_19822575_ChIP-Seq_HepG2_Human0.81973717
169TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80183682
170JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79621189
171CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78855128
172* KDM2B_26808549_Chip-Seq_K562_Human0.76345503
173TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74946326
174SMC4_20622854_ChIP-Seq_HELA_Human0.74938058
175KDM2B_26808549_Chip-Seq_SUP-B15_Human0.74488796
176TCF7_22412390_ChIP-Seq_EML_Mouse0.72872394
177NFIB_24661679_ChIP-Seq_LUNG_Mouse0.72422102
178CHD1_26751641_Chip-Seq_LNCaP_Human0.71661495
179CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.71301945
180RXR_22108803_ChIP-Seq_LS180_Human0.70947534
181GATA1_19941826_ChIP-Seq_K562_Human0.70696824
182* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70440037

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.59811598
2* MP0004957_abnormal_blastocyst_morpholog3.73930766
3MP0010352_gastrointestinal_tract_polyps3.57100349
4MP0004264_abnormal_extraembryonic_tissu3.30874190
5MP0003111_abnormal_nucleus_morphology3.13135660
6MP0003941_abnormal_skin_development3.04801131
7MP0005275_abnormal_skin_tensile2.87289902
8MP0010234_abnormal_vibrissa_follicle2.79929174
9MP0002796_impaired_skin_barrier2.74853304
10MP0008057_abnormal_DNA_replication2.69030323
11MP0005360_urolithiasis2.62071203
12MP0010030_abnormal_orbit_morphology2.48451869
13MP0005409_darkened_coat_color2.44397038
14MP0003283_abnormal_digestive_organ2.33964136
15MP0003077_abnormal_cell_cycle2.32039111
16MP0010094_abnormal_chromosome_stability2.27443895
17MP0003119_abnormal_digestive_system2.08778837
18MP0000462_abnormal_digestive_system1.98777628
19MP0000537_abnormal_urethra_morphology1.95426394
20MP0005501_abnormal_skin_physiology1.94803264
21MP0003718_maternal_effect1.92475289
22MP0002653_abnormal_ependyma_morphology1.92371822
23MP0008932_abnormal_embryonic_tissue1.89424536
24MP0003705_abnormal_hypodermis_morpholog1.84210490
25MP0001730_embryonic_growth_arrest1.83894886
26MP0003315_abnormal_perineum_morphology1.76475217
27MP0005380_embryogenesis_phenotype1.74762384
28MP0001672_abnormal_embryogenesis/_devel1.74762384
29MP0000350_abnormal_cell_proliferation1.69455041
30* MP0000490_abnormal_crypts_of1.68407053
31MP0005377_hearing/vestibular/ear_phenot1.67805247
32MP0003878_abnormal_ear_physiology1.67805247
33MP0002139_abnormal_hepatobiliary_system1.66851670
34MP0003786_premature_aging1.66684712
35MP0002084_abnormal_developmental_patter1.66302767
36MP0004947_skin_inflammation1.65227728
37MP0003453_abnormal_keratinocyte_physiol1.64492282
38* MP0002086_abnormal_extraembryonic_tissu1.62810254
39MP0002254_reproductive_system_inflammat1.60437296
40* MP0002085_abnormal_embryonic_tissue1.58553319
41MP0003123_paternal_imprinting1.58540267
42MP0000762_abnormal_tongue_morphology1.58392052
43MP0001849_ear_inflammation1.57724897
44MP0010155_abnormal_intestine_physiology1.55153097
45MP0001697_abnormal_embryo_size1.52889311
46MP0003191_abnormal_cellular_cholesterol1.51914136
47MP0008058_abnormal_DNA_repair1.49028394
48MP0005367_renal/urinary_system_phenotyp1.47423534
49MP0000516_abnormal_urinary_system1.47423534
50MP0004043_abnormal_pH_regulation1.47271278
51MP0009840_abnormal_foam_cell1.47005046
52MP0004133_heterotaxia1.45946941
53MP0005085_abnormal_gallbladder_physiolo1.45314339
54MP0003984_embryonic_growth_retardation1.45277305
55MP0009780_abnormal_chondrocyte_physiolo1.45048487
56MP0002088_abnormal_embryonic_growth/wei1.44471587
57MP0002098_abnormal_vibrissa_morphology1.43488846
58MP0003890_abnormal_embryonic-extraembry1.41408311
59MP0003183_abnormal_peptide_metabolism1.40071587
60MP0009053_abnormal_anal_canal1.37691555
61MP0005076_abnormal_cell_differentiation1.37554865
62MP0003566_abnormal_cell_adhesion1.36590241
63MP0004197_abnormal_fetal_growth/weight/1.35568493
64MP0001664_abnormal_digestion1.34212863
65MP0001216_abnormal_epidermal_layer1.32476954
66MP0000467_abnormal_esophagus_morphology1.27907437
67MP0005365_abnormal_bile_salt1.26232253
68* MP0000477_abnormal_intestine_morphology1.26181390
69* MP0002080_prenatal_lethality1.24394316
70MP0010678_abnormal_skin_adnexa1.23841995
71MP0002111_abnormal_tail_morphology1.18604851
72MP0002060_abnormal_skin_morphology1.17975024
73MP0000383_abnormal_hair_follicle1.17057142
74MP0003806_abnormal_nucleotide_metabolis1.16437289
75MP0005023_abnormal_wound_healing1.16304459
76MP0003567_abnormal_fetal_cardiomyocyte1.16110495
77MP0001293_anophthalmia1.14659870
78MP0001765_abnormal_ion_homeostasis1.12892858
79MP0008007_abnormal_cellular_replicative1.12165789
80MP0000465_gastrointestinal_hemorrhage1.07965706
81MP0000566_synostosis1.06782370
82MP0000427_abnormal_hair_cycle1.04401640
83MP0001873_stomach_inflammation1.03349527
84MP0004019_abnormal_vitamin_homeostasis1.01079133
85MP0004272_abnormal_basement_membrane0.99356373
86MP0003950_abnormal_plasma_membrane0.99151652
87MP0003136_yellow_coat_color0.98521977
88MP0003937_abnormal_limbs/digits/tail_de0.98336088
89MP0008004_abnormal_stomach_pH0.96291333
90MP0000470_abnormal_stomach_morphology0.96067556
91MP0002009_preneoplasia0.95632533
92MP0000377_abnormal_hair_follicle0.95442338
93MP0002277_abnormal_respiratory_mucosa0.95257004
94MP0003938_abnormal_ear_development0.94494806
95MP0003866_abnormal_defecation0.94078083
96MP0001188_hyperpigmentation0.93884851
97MP0002877_abnormal_melanocyte_morpholog0.93378746
98MP0005451_abnormal_body_composition0.91501071
99MP0000613_abnormal_salivary_gland0.91160853
100MP0003936_abnormal_reproductive_system0.90979925
101MP0005666_abnormal_adipose_tissue0.89917685
102MP0000432_abnormal_head_morphology0.89247355
103MP0000627_abnormal_mammary_gland0.89129071
104MP0002249_abnormal_larynx_morphology0.88259156
105MP0003755_abnormal_palate_morphology0.87692905
106MP0009643_abnormal_urine_homeostasis0.86892640
107MP0000579_abnormal_nail_morphology0.86764997
108MP0001191_abnormal_skin_condition0.86708031
109MP0000367_abnormal_coat/_hair0.86315037
110* MP0004782_abnormal_surfactant_physiolog0.86175829
111MP0002896_abnormal_bone_mineralization0.84981049
112MP0000313_abnormal_cell_death0.83974412
113MP0010771_integument_phenotype0.82511866
114MP0002136_abnormal_kidney_physiology0.81215930
115MP0010307_abnormal_tumor_latency0.81106496
116MP0000647_abnormal_sebaceous_gland0.81043192
117MP0009278_abnormal_bone_marrow0.77378342
118MP0001286_abnormal_eye_development0.76953923
119MP0003868_abnormal_feces_composition0.76277374
120MP0000858_altered_metastatic_potential0.74386817
121MP0001666_abnormal_nutrient_absorption0.74186786
122MP0008875_abnormal_xenobiotic_pharmacok0.74112427
123MP0000678_abnormal_parathyroid_gland0.74011289
124MP0001145_abnormal_male_reproductive0.73662659
125MP0002092_abnormal_eye_morphology0.73401029
126MP0002019_abnormal_tumor_incidence0.72278162
127MP0005257_abnormal_intraocular_pressure0.71814365
128MP0005395_other_phenotype0.71196147
129MP0002234_abnormal_pharynx_morphology0.71121590
130MP0009379_abnormal_foot_pigmentation0.69633051
131MP0004185_abnormal_adipocyte_glucose0.68572335
132MP0005670_abnormal_white_adipose0.68360657
133MP0005075_abnormal_melanosome_morpholog0.68176969
134MP0004381_abnormal_hair_follicle0.67957971
135MP0005266_abnormal_metabolism0.65126861
136MP0009931_abnormal_skin_appearance0.64524120
137MP0005165_increased_susceptibility_to0.63994571
138MP0004858_abnormal_nervous_system0.62980883
139MP0003091_abnormal_cell_migration0.61643663
140MP0008961_abnormal_basal_metabolism0.60601436
141MP0001881_abnormal_mammary_gland0.59336826
142MP0002006_tumorigenesis0.59124535
143MP0002166_altered_tumor_susceptibility0.58438302
144MP0001851_eye_inflammation0.58386962
145MP0001243_abnormal_dermal_layer0.58109274
146MP0006138_congestive_heart_failure0.57422040
147MP0005375_adipose_tissue_phenotype0.55623877
148MP0005381_digestive/alimentary_phenotyp0.55238135
149MP0005636_abnormal_mineral_homeostasis0.53571715
150* MP0005166_decreased_susceptibility_to0.50942953
151MP0003300_gastrointestinal_ulcer0.50708349
152MP0003045_fibrosis0.49783407
153MP0003252_abnormal_bile_duct0.47782877
154MP0001663_abnormal_digestive_system0.43809430

Predicted human phenotypes

RankGene SetZ-score
1Palmoplantar hyperkeratosis (HP:0000972)4.92532326
2Abnormality of nail color (HP:0100643)4.82594091
3Hyperactive renin-angiotensin system (HP:0000841)4.63928802
4Palmar hyperkeratosis (HP:0010765)4.63362880
5Thick nail (HP:0001805)4.17173747
6Breast hypoplasia (HP:0003187)4.08503454
7Ileus (HP:0002595)3.93709753
8Abnormal hair laboratory examination (HP:0003328)3.76770776
9Absent radius (HP:0003974)3.61121903
10Aplasia/hypoplasia of the humerus (HP:0006507)3.56511587
11Trismus (HP:0000211)3.48676007
12Absent forearm bone (HP:0003953)3.40699312
13Aplasia involving forearm bones (HP:0009822)3.40699312
14Rib fusion (HP:0000902)3.40685906
15Atrophic scars (HP:0001075)3.39449589
16Short humerus (HP:0005792)3.37077190
17Flat acetabular roof (HP:0003180)3.30062416
18Popliteal pterygium (HP:0009756)3.29282322
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.26306212
20Ependymoma (HP:0002888)3.19401481
21Concave nail (HP:0001598)3.00582245
22Hypoplasia of dental enamel (HP:0006297)2.96210188
23Ridged nail (HP:0001807)2.95500708
24Abnormality of the labia minora (HP:0012880)2.88448536
25Abnormal hemoglobin (HP:0011902)2.88049755
26Chronic bronchitis (HP:0004469)2.84600846
27Congenital ichthyosiform erythroderma (HP:0007431)2.83173028
28Increased IgE level (HP:0003212)2.82116996
29Abnormality of the axillary hair (HP:0100134)2.76588422
30Abnormality of secondary sexual hair (HP:0009888)2.76588422
31Pili torti (HP:0003777)2.75539973
32Reticulocytopenia (HP:0001896)2.75147113
33Right ventricular cardiomyopathy (HP:0011663)2.73365338
34Rough bone trabeculation (HP:0100670)2.73300840
35Absent thumb (HP:0009777)2.71369555
36Premature ovarian failure (HP:0008209)2.70311433
37Corneal erosion (HP:0200020)2.69154726
38Esophageal atresia (HP:0002032)2.67047285
39Impulsivity (HP:0100710)2.64448701
40Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.59642652
41Shawl scrotum (HP:0000049)2.58989571
42Hypoplastic labia majora (HP:0000059)2.58023206
43Stenosis of the external auditory canal (HP:0000402)2.55696001
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.55633764
45Alopecia of scalp (HP:0002293)2.55074427
46Pustule (HP:0200039)2.54364547
47Fragile nails (HP:0001808)2.54093192
48Fragile skin (HP:0001030)2.53679986
49Patellar aplasia (HP:0006443)2.53173477
50Selective tooth agenesis (HP:0001592)2.50529569
51Aplasia/Hypoplasia of the patella (HP:0006498)2.49819450
52Abnormality of the dental root (HP:0006486)2.49672891
53Taurodontia (HP:0000679)2.49672891
54Abnormality of permanent molar morphology (HP:0011071)2.49672891
55Milia (HP:0001056)2.48309989
56Erythema (HP:0010783)2.47806446
57Abnormality of monocarboxylic acid metabolism (HP:0010996)2.47172772
58Oligodontia (HP:0000677)2.47111497
59Decreased circulating renin level (HP:0003351)2.46401388
60Biliary tract neoplasm (HP:0100574)2.45621875
61Sparse eyelashes (HP:0000653)2.43436064
62Carpal bone hypoplasia (HP:0001498)2.42178433
63Abnormality of renin-angiotensin system (HP:0000847)2.41718575
64Abnormality of the salivary glands (HP:0010286)2.41069048
65Tongue fasciculations (HP:0001308)2.40514698
66Rectal fistula (HP:0100590)2.39512496
67Rectovaginal fistula (HP:0000143)2.39512496
68Abnormality of the labia majora (HP:0012881)2.39495924
69Colon cancer (HP:0003003)2.39055884
70Ureteral duplication (HP:0000073)2.37049302
71Abnormality of cells of the erythroid lineage (HP:0012130)2.36045178
72Birth length less than 3rd percentile (HP:0003561)2.34786003
73Cheilitis (HP:0100825)2.33729972
74Erythroderma (HP:0001019)2.33087596
75Abnormality of molar morphology (HP:0011070)2.31751335
76Abnormality of molar (HP:0011077)2.31751335
77Dehydration (HP:0001944)2.30702332
78Sparse scalp hair (HP:0002209)2.30699777
79Aplasia/Hypoplasia of the sacrum (HP:0008517)2.26941724
80Hypoplasia of the radius (HP:0002984)2.25752277
81Absent eyelashes (HP:0000561)2.25731784
82Multiple enchondromatosis (HP:0005701)2.25607082
83Abnormality of chloride homeostasis (HP:0011422)2.25591215
84Chromosomal breakage induced by crosslinking agents (HP:0003221)2.25079717
85Abnormality of the preputium (HP:0100587)2.24687037
86Focal segmental glomerulosclerosis (HP:0000097)2.24292103
87Palmoplantar keratoderma (HP:0000982)2.22471726
88Muscle fibrillation (HP:0010546)2.22345844
89Amniotic constriction ring (HP:0009775)2.20983796
90Abnormality of placental membranes (HP:0011409)2.20983796
91Rhabdomyosarcoma (HP:0002859)2.20680669
92Nail dystrophy (HP:0008404)2.20666102
93Fused cervical vertebrae (HP:0002949)2.19318271
94Abnormality of the dental pulp (HP:0006479)2.19295286
95Plantar hyperkeratosis (HP:0007556)2.17807980
96Abnormality of the astrocytes (HP:0100707)2.17439220
97Astrocytoma (HP:0009592)2.17439220
98Hyperkalemia (HP:0002153)2.16750586
99Abnormality of the distal phalanges of the toes (HP:0010182)2.16245084
100Nasolacrimal duct obstruction (HP:0000579)2.16119188
101Abnormality of the 1st metacarpal (HP:0010009)2.14169526
102Aplasia cutis congenita (HP:0001057)2.13423463
103Chromsome breakage (HP:0040012)2.13138077
104Ankyloglossia (HP:0010296)2.13129021
105Acanthosis nigricans (HP:0000956)2.12782318
106Abnormal biliary tract morphology (HP:0012440)2.12506434
107Abnormality of the gastric mucosa (HP:0004295)2.12330290
108Vaginal fistula (HP:0004320)2.10713217
109Lip pit (HP:0100267)2.09898470
110Woolly hair (HP:0002224)2.09446963
111Anal stenosis (HP:0002025)2.09345094
112Missing ribs (HP:0000921)2.07929296
113Intestinal fistula (HP:0100819)2.07828747
114Abnormal trabecular bone morphology (HP:0100671)2.07437347
115Nasal polyposis (HP:0100582)2.07152865
116Natal tooth (HP:0000695)2.06775936
117Abnormality of the distal phalanx of the thumb (HP:0009617)2.06152778
118Blepharitis (HP:0000498)2.05945931
119Abnormality of the umbilical cord (HP:0010881)2.04932702
120Macrocytic anemia (HP:0001972)2.04528855
121Abnormality of proline metabolism (HP:0010907)2.04194566
122Hydroxyprolinuria (HP:0003080)2.04194566
123Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.03779877
124Vertebral hypoplasia (HP:0008417)2.03779877
125Advanced eruption of teeth (HP:0006288)2.03627470
126Xerostomia (HP:0000217)2.02294001
127Dry hair (HP:0011359)2.01965035
128Secondary amenorrhea (HP:0000869)2.01048143
129Abnormal respiratory motile cilium physiology (HP:0012261)2.00936329
130Cerebral hypomyelination (HP:0006808)2.00863401
131Aplasia/Hypoplasia involving the musculature (HP:0001460)1.98378391
132Myopathic facies (HP:0002058)1.97432732
133Curly hair (HP:0002212)1.97315852
134Glioma (HP:0009733)1.95793430
135Oral leukoplakia (HP:0002745)1.95678353
136Pterygium (HP:0001059)1.95405572
137Septate vagina (HP:0001153)1.95387766
138Aplasia involving bones of the extremities (HP:0009825)1.94859719
139Aplasia involving bones of the upper limbs (HP:0009823)1.94859719
140Aplasia of the phalanges of the hand (HP:0009802)1.94859719
141Abnormality of the fetal cardiovascular system (HP:0010948)1.94414361
142Abnormal umbilical cord blood vessels (HP:0011403)1.94414361
143Single umbilical artery (HP:0001195)1.94414361
144Rhinitis (HP:0012384)1.93929156
145Vertebral clefting (HP:0008428)1.93510536
146Abdominal distention (HP:0003270)1.93368355
147Mildly elevated creatine phosphokinase (HP:0008180)1.92072065
148Gastrointestinal atresia (HP:0002589)1.91650629
149Absent/shortened dynein arms (HP:0200106)1.91447894
150Dynein arm defect of respiratory motile cilia (HP:0012255)1.91447894
151Hyperaldosteronism (HP:0000859)1.90637874
152Hypotrichosis (HP:0001006)1.90496304
153Microretrognathia (HP:0000308)1.90403473
154Malnutrition (HP:0004395)1.90135866
155Abnormality of the nasal mucosa (HP:0000433)1.89896705
156Abnormality of the ileum (HP:0001549)1.89167016
157Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.87785667
158Onycholysis (HP:0001806)1.87607602
159Abnormality of small intestinal villus morphology (HP:0011472)1.86403445
160Villous atrophy (HP:0011473)1.86403445
161Degeneration of anterior horn cells (HP:0002398)1.85186696
162Abnormality of the anterior horn cell (HP:0006802)1.85186696
163Abnormal number of erythroid precursors (HP:0012131)1.84826537
164Fat malabsorption (HP:0002630)1.84257153
165Neonatal short-limb short stature (HP:0008921)1.83878704
166Eczematoid dermatitis (HP:0000976)1.83688968
167Spinal muscular atrophy (HP:0007269)1.83605521
168Ventricular tachycardia (HP:0004756)1.83338490
169Glomerulosclerosis (HP:0000096)1.82970642
170Abnormal respiratory epithelium morphology (HP:0012253)1.82310941
171Abnormal respiratory motile cilium morphology (HP:0005938)1.82310941
172Aplasia/Hypoplasia of the ulna (HP:0006495)1.81569087
173Abnormal blistering of the skin (HP:0008066)1.81361820
174Abnormality of abdominal situs (HP:0011620)1.81090422
175Abdominal situs inversus (HP:0003363)1.81090422
176Proximal placement of thumb (HP:0009623)1.79668187
177Neoplasm of the pancreas (HP:0002894)1.79391700
178Progressive muscle weakness (HP:0003323)1.79326376
179Gastrointestinal carcinoma (HP:0002672)1.77794769

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.44407225
2CDK123.65358927
3BUB13.50073477
4AKT33.44783044
5STK243.17082743
6WEE13.11617262
7TTK2.78643903
8RPS6KB22.49338230
9NEK22.15384920
10STK392.14199549
11MAP3K22.05730814
12SIK12.05236888
13ERN12.03570690
14MAP2K21.96796968
15CDK71.77477222
16MST41.75995476
17STK38L1.70740379
18NME11.67010118
19DDR21.66063058
20PLK11.65810392
21CHEK21.53378295
22MAP3K111.52894723
23NEK11.50333932
24ICK1.50321482
25PRKCI1.46190601
26AURKB1.42696741
27IRAK31.41859122
28LATS21.34431809
29DYRK31.33366498
30BRSK21.33137497
31MAPKAPK31.29774625
32MST1R1.27961682
33MATK1.27179178
34MAP3K31.24727574
35TYRO31.19776187
36EPHB11.19253838
37AURKA1.17502085
38PAK41.16138196
39NME21.15766844
40PIM21.15468801
41SMG11.13933142
42MET1.11854324
43PTK61.10322994
44EEF2K1.09189974
45MAPK151.07186850
46GRK61.05566808
47TSSK61.03282010
48BCKDK1.03254565
49MAP3K81.03239480
50MAP3K121.01153611
51STK100.98454193
52LATS10.98101614
53TRIB30.97618104
54PRKG20.97203212
55PRPF4B0.96207798
56PBK0.93143707
57TGFBR10.90483351
58TLK10.89785540
59PIK3CA0.89235456
60TAOK10.88117284
61EIF2AK10.87710105
62CDC70.86951425
63TESK20.85119747
64CDK40.84203672
65CHEK10.83655115
66BRAF0.83446458
67OXSR10.83220579
68ZAK0.82013175
69MTOR0.79723125
70ACVR1B0.76948185
71FGFR40.76432991
72EIF2AK30.75036877
73PAK10.74810280
74SRPK10.73675249
75PIM10.71676216
76STK380.71251320
77PTK20.71098456
78EPHB20.70073210
79MAP3K10.69329239
80LMTK20.69055831
81FGFR30.67149219
82MAP3K90.66433286
83CDK20.65737086
84PLK40.64903387
85ALK0.63068934
86PDK20.61461362
87TRPM70.61344634
88PLK30.61155871
89AKT20.60541358
90ATR0.60483803
91STK30.60405649
92TESK10.58975686
93CDK60.58509914
94MELK0.57709190
95DMPK0.57555571
96MAP2K60.57270277
97CSNK1E0.56671871
98NEK60.55864767
99PASK0.55587533
100CDC42BPA0.55355252
101FER0.55057881
102RPS6KA40.52981691
103BRSK10.50968760
104FGFR10.50672896
105WNK40.49635566
106MAP3K60.49471895
107BMX0.48315722
108PDK30.48263907
109PDK40.48263907
110BRD40.47880657
111ATM0.47315604
112MAP3K100.46831354
113PDGFRB0.44875879
114DYRK20.44819661
115ABL20.44272133
116PRKAA20.44187823
117TAOK20.43009028
118CSNK2A10.42338029
119RIPK10.42182428
120CSNK2A20.42049048
121ERBB20.41822236
122MYLK0.41414033
123SCYL20.41382430
124PDPK10.39996764
125ERBB30.39640316
126FRK0.37862305
127MUSK0.37860475
128MAPK110.36622174
129GRK10.35870664
130MAP3K70.35639498
131MAPK70.34777478
132CHUK0.34437295
133TGFBR20.34429216
134ARAF0.33968589
135VRK10.33929392
136RPS6KA10.33665192
137EPHA30.33484065
138STK40.33211614
139IRAK10.33010485
140LRRK20.32304518
141DYRK1B0.32123160
142MAP2K10.32092914
143CDK80.31743893
144GSK3A0.31608570
145PDGFRA0.31048543
146MAPKAPK20.29888298
147CDK10.29614757
148NTRK10.28969930
149CDK90.28515062
150PRKD20.28309301
151RPS6KA20.26828320
152TBK10.24023681
153CSK0.22552722

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.56188501
2Ribosome_Homo sapiens_hsa030103.54422791
3Mismatch repair_Homo sapiens_hsa034303.39696438
4DNA replication_Homo sapiens_hsa030303.05328621
5RNA transport_Homo sapiens_hsa030132.90594639
6RNA polymerase_Homo sapiens_hsa030202.72029637
7Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.67168596
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.41160454
9Base excision repair_Homo sapiens_hsa034102.31008746
10Fructose and mannose metabolism_Homo sapiens_hsa000512.29628156
11Spliceosome_Homo sapiens_hsa030402.22643633
12Proteasome_Homo sapiens_hsa030502.19583320
13Folate biosynthesis_Homo sapiens_hsa007902.16364360
14Vitamin B6 metabolism_Homo sapiens_hsa007502.14851276
15Cell cycle_Homo sapiens_hsa041102.09885787
16Starch and sucrose metabolism_Homo sapiens_hsa005002.09441341
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.04612948
18Homologous recombination_Homo sapiens_hsa034401.99709168
19Nucleotide excision repair_Homo sapiens_hsa034201.92315593
20Arginine biosynthesis_Homo sapiens_hsa002201.90057508
21Retinol metabolism_Homo sapiens_hsa008301.86527006
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.78030395
23p53 signaling pathway_Homo sapiens_hsa041151.76178631
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.75115061
25Phenylalanine metabolism_Homo sapiens_hsa003601.75112937
26Galactose metabolism_Homo sapiens_hsa000521.73272791
27Hippo signaling pathway_Homo sapiens_hsa043901.69970381
28Pyrimidine metabolism_Homo sapiens_hsa002401.69726680
29Fanconi anemia pathway_Homo sapiens_hsa034601.67292507
30Tight junction_Homo sapiens_hsa045301.61112651
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.60433387
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.56133979
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.56014364
34Hedgehog signaling pathway_Homo sapiens_hsa043401.54481998
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.52279354
36Fat digestion and absorption_Homo sapiens_hsa049751.50011942
37mRNA surveillance pathway_Homo sapiens_hsa030151.47071875
38Basal cell carcinoma_Homo sapiens_hsa052171.44561570
39Glutathione metabolism_Homo sapiens_hsa004801.42426521
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.42077999
41Mineral absorption_Homo sapiens_hsa049781.40528660
42Bile secretion_Homo sapiens_hsa049761.38037298
43One carbon pool by folate_Homo sapiens_hsa006701.36120581
44Renin-angiotensin system_Homo sapiens_hsa046141.31158529
45Caffeine metabolism_Homo sapiens_hsa002321.31146918
46Bladder cancer_Homo sapiens_hsa052191.30500936
47Basal transcription factors_Homo sapiens_hsa030221.22380164
48PPAR signaling pathway_Homo sapiens_hsa033201.22124041
49Adherens junction_Homo sapiens_hsa045201.16649376
50Pancreatic secretion_Homo sapiens_hsa049721.15345992
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.14766844
52ECM-receptor interaction_Homo sapiens_hsa045121.12731001
53Amoebiasis_Homo sapiens_hsa051461.12046281
54Arachidonic acid metabolism_Homo sapiens_hsa005901.10557949
55Pentose phosphate pathway_Homo sapiens_hsa000301.09729213
56Thyroid cancer_Homo sapiens_hsa052161.08893207
57Sulfur relay system_Homo sapiens_hsa041221.07212663
58Hepatitis C_Homo sapiens_hsa051601.03574812
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98226647
60Vitamin digestion and absorption_Homo sapiens_hsa049770.97726981
61Linoleic acid metabolism_Homo sapiens_hsa005910.95110451
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94888962
63RNA degradation_Homo sapiens_hsa030180.93947254
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93604041
65Fatty acid biosynthesis_Homo sapiens_hsa000610.93554442
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.92364633
67Tyrosine metabolism_Homo sapiens_hsa003500.92201136
68Arginine and proline metabolism_Homo sapiens_hsa003300.90795883
69Ether lipid metabolism_Homo sapiens_hsa005650.87428840
70Regulation of autophagy_Homo sapiens_hsa041400.84257254
71Fatty acid degradation_Homo sapiens_hsa000710.84139679
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82931483
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.81430043
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80933630
75Purine metabolism_Homo sapiens_hsa002300.78023060
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76762595
77Oocyte meiosis_Homo sapiens_hsa041140.75457165
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74891972
79Biosynthesis of amino acids_Homo sapiens_hsa012300.74808029
80TGF-beta signaling pathway_Homo sapiens_hsa043500.74057668
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72590415
82Nitrogen metabolism_Homo sapiens_hsa009100.72552689
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72016752
84Insulin resistance_Homo sapiens_hsa049310.71580647
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67434231
86MicroRNAs in cancer_Homo sapiens_hsa052060.66735163
87mTOR signaling pathway_Homo sapiens_hsa041500.66312133
88Small cell lung cancer_Homo sapiens_hsa052220.63137723
89Dorso-ventral axis formation_Homo sapiens_hsa043200.62934865
90Notch signaling pathway_Homo sapiens_hsa043300.61259396
91Focal adhesion_Homo sapiens_hsa045100.60643564
92Epstein-Barr virus infection_Homo sapiens_hsa051690.57755428
93GnRH signaling pathway_Homo sapiens_hsa049120.57607499
94Endocytosis_Homo sapiens_hsa041440.56783182
95Wnt signaling pathway_Homo sapiens_hsa043100.55110671
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53899069
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53501798
98Non-homologous end-joining_Homo sapiens_hsa034500.52955771
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52142398
100Selenocompound metabolism_Homo sapiens_hsa004500.51453788
101Sphingolipid metabolism_Homo sapiens_hsa006000.51271474
102Toxoplasmosis_Homo sapiens_hsa051450.51187566
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51170974
104Choline metabolism in cancer_Homo sapiens_hsa052310.51085970
105Huntingtons disease_Homo sapiens_hsa050160.50981043
106Viral carcinogenesis_Homo sapiens_hsa052030.48635879
107Inositol phosphate metabolism_Homo sapiens_hsa005620.48496822
108Renin secretion_Homo sapiens_hsa049240.47099858
109Pancreatic cancer_Homo sapiens_hsa052120.46631121
110ABC transporters_Homo sapiens_hsa020100.46539742
111Carbon metabolism_Homo sapiens_hsa012000.45304812
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.44515820
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43465505
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43079136
115Chronic myeloid leukemia_Homo sapiens_hsa052200.40702131
116VEGF signaling pathway_Homo sapiens_hsa043700.39641941
117Pathways in cancer_Homo sapiens_hsa052000.39426209
118TNF signaling pathway_Homo sapiens_hsa046680.39246793
119Insulin signaling pathway_Homo sapiens_hsa049100.38991059
120Salmonella infection_Homo sapiens_hsa051320.38476423
121Other glycan degradation_Homo sapiens_hsa005110.38449999
122Protein digestion and absorption_Homo sapiens_hsa049740.38064762
123HTLV-I infection_Homo sapiens_hsa051660.37270498
124Cysteine and methionine metabolism_Homo sapiens_hsa002700.37258429
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36905710
126Metabolic pathways_Homo sapiens_hsa011000.36337531
127ErbB signaling pathway_Homo sapiens_hsa040120.35895456
128Influenza A_Homo sapiens_hsa051640.33533257
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32866429
130Vibrio cholerae infection_Homo sapiens_hsa051100.32474629
131Sulfur metabolism_Homo sapiens_hsa009200.32023926
132AMPK signaling pathway_Homo sapiens_hsa041520.31335496
133Chemical carcinogenesis_Homo sapiens_hsa052040.30717653
134Renal cell carcinoma_Homo sapiens_hsa052110.29892685
135Histidine metabolism_Homo sapiens_hsa003400.29009568
136Thyroid hormone synthesis_Homo sapiens_hsa049180.28627334
137Proteoglycans in cancer_Homo sapiens_hsa052050.28453835
138Ovarian steroidogenesis_Homo sapiens_hsa049130.28364972
139Endometrial cancer_Homo sapiens_hsa052130.27478523
140Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26981703
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26955756
142Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26439080
143Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26221021
144Circadian rhythm_Homo sapiens_hsa047100.24673883
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.23635442
146Leukocyte transendothelial migration_Homo sapiens_hsa046700.20769302
147Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.20326791
148Glycerolipid metabolism_Homo sapiens_hsa005610.19546087
149Systemic lupus erythematosus_Homo sapiens_hsa053220.18862062
150Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18787328
151Herpes simplex infection_Homo sapiens_hsa051680.17534816
152Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.16424749
153Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16021974
154Prostate cancer_Homo sapiens_hsa052150.15984011

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