KLF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.55529643
2negative regulation of cell killing (GO:0031342)4.48054491
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.48054491
4negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.43141409
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.04711650
6response to muramyl dipeptide (GO:0032495)3.99030003
7negative thymic T cell selection (GO:0045060)3.90326861
8regulation of gamma-delta T cell activation (GO:0046643)3.83191710
9regulation of gamma-delta T cell differentiation (GO:0045586)3.78523838
10positive thymic T cell selection (GO:0045059)3.78077338
11negative T cell selection (GO:0043383)3.77156037
12neutrophil activation involved in immune response (GO:0002283)3.64324972
13NIK/NF-kappaB signaling (GO:0038061)3.52414894
14regulation of interleukin-12 biosynthetic process (GO:0045075)3.51619204
15positive regulation by symbiont of host defense response (GO:0052509)3.46897100
16modulation by symbiont of host defense response (GO:0052031)3.46897100
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.46897100
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.46897100
19positive regulation by organism of defense response of other organism involved in symbiotic interact3.46897100
20modulation by symbiont of host immune response (GO:0052553)3.46897100
21hepatocyte apoptotic process (GO:0097284)3.46122215
22cellular extravasation (GO:0045123)3.43511073
23response to peptidoglycan (GO:0032494)3.33685449
24neutrophil activation (GO:0042119)3.30268380
25microglial cell activation (GO:0001774)3.28695408
26regulation of dendritic cell antigen processing and presentation (GO:0002604)3.25339966
27negative regulation of T cell mediated immunity (GO:0002710)3.21138575
28positive T cell selection (GO:0043368)3.19331506
29negative regulation of T-helper cell differentiation (GO:0045623)3.17537201
30negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.17537201
31antigen processing and presentation of endogenous antigen (GO:0019883)3.17124302
32negative regulation of bone resorption (GO:0045779)3.16519665
33regulation of alpha-beta T cell proliferation (GO:0046640)3.15465036
34cellular response to interleukin-15 (GO:0071350)3.14343321
35negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.13152734
36granulocyte activation (GO:0036230)3.12452259
37response to interleukin-15 (GO:0070672)3.09320372
38thymic T cell selection (GO:0045061)3.09226774
39negative regulation of innate immune response (GO:0045824)3.08807383
40regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.06170469
41positive regulation of interferon-alpha production (GO:0032727)3.04298785
42regulation of regulatory T cell differentiation (GO:0045589)3.04178574
43macrophage activation (GO:0042116)3.02192448
44dendritic cell chemotaxis (GO:0002407)3.02149500
45regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.00758267
46positive regulation of antigen processing and presentation (GO:0002579)2.99937767
47energy homeostasis (GO:0097009)2.99451910
48antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.99210514
49antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.99210514
50monocyte chemotaxis (GO:0002548)2.99074620
51T cell selection (GO:0045058)2.96692887
52positive regulation of gamma-delta T cell activation (GO:0046645)2.96205974
53cellular response to exogenous dsRNA (GO:0071360)2.95509518
54macrophage activation involved in immune response (GO:0002281)2.94427498
55B cell receptor signaling pathway (GO:0050853)2.93316543
56positive regulation of alpha-beta T cell proliferation (GO:0046641)2.93077773
57negative regulation of interleukin-12 production (GO:0032695)2.93049181
58regulation of interferon-alpha production (GO:0032647)2.91825059
59negative regulation of interleukin-6 production (GO:0032715)2.91536399
60germinal center formation (GO:0002467)2.90484532
61regulation of T-helper 1 cell differentiation (GO:0045625)2.90442281
62negative regulation of lymphocyte mediated immunity (GO:0002707)2.89937431
63detection of other organism (GO:0098543)2.86853807
64negative regulation of interleukin-8 production (GO:0032717)2.86586579
65response to type I interferon (GO:0034340)2.86568940
66defense response to protozoan (GO:0042832)2.86142979
67type I interferon signaling pathway (GO:0060337)2.85659152
68cellular response to type I interferon (GO:0071357)2.85659152
69regulation of T cell mediated cytotoxicity (GO:0001914)2.85405299
70myeloid dendritic cell activation (GO:0001773)2.84667271
71dendritic cell migration (GO:0036336)2.83665290
72leukocyte aggregation (GO:0070486)2.82759245
73regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.82596285
74positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.82541173
75T cell migration (GO:0072678)2.80459228
76positive regulation of interleukin-12 production (GO:0032735)2.80392184
77myeloid dendritic cell differentiation (GO:0043011)2.78599560
78regulation of B cell differentiation (GO:0045577)2.78305964
79positive regulation of T cell differentiation in thymus (GO:0033089)2.78209281
80negative regulation of type 2 immune response (GO:0002829)2.77874751
81positive regulation of cellular amide metabolic process (GO:0034250)2.75858762
82detection of bacterium (GO:0016045)2.75803662
83mast cell activation (GO:0045576)2.75270773
84negative regulation of interleukin-1 beta production (GO:0032691)2.75138801
85regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.75126922
86growth hormone receptor signaling pathway (GO:0060396)2.75088038
87regulation of T cell receptor signaling pathway (GO:0050856)2.73310130
88negative regulation of leukocyte mediated immunity (GO:0002704)2.72835108
89interferon-gamma-mediated signaling pathway (GO:0060333)2.71134996
90respiratory burst (GO:0045730)2.68771982
91positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.68589682
92regulation of interferon-beta biosynthetic process (GO:0045357)2.68386568
93positive regulation of alpha-beta T cell differentiation (GO:0046638)2.67612561
94positive regulation of B cell differentiation (GO:0045579)2.67450518
95positive regulation of T cell mediated cytotoxicity (GO:0001916)2.66756251
96alpha-beta T cell differentiation involved in immune response (GO:0002293)2.66640729
97regulation of chemokine secretion (GO:0090196)2.66407742
98positive regulation of T-helper 1 type immune response (GO:0002827)2.66001342
99regulation of antigen processing and presentation (GO:0002577)2.65880720
100regulation of T-helper 1 type immune response (GO:0002825)2.65876134
101myeloid leukocyte activation (GO:0002274)2.64927651
102positive regulation of T cell differentiation (GO:0045582)2.64629432
103positive regulation of tolerance induction (GO:0002645)2.64595306
104regulation of T-helper 2 cell differentiation (GO:0045628)2.63855916
105myeloid cell activation involved in immune response (GO:0002275)2.63746827
106regulation of tolerance induction (GO:0002643)2.63696407
107regulation of alpha-beta T cell activation (GO:0046634)2.63324178
108B cell homeostasis (GO:0001782)2.62304210
109regulation of alpha-beta T cell differentiation (GO:0046637)2.59623305
110T-helper cell differentiation (GO:0042093)2.58291067
111CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.58291067
112response to host immune response (GO:0052572)2.58054546
113response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.58054546
114positive regulation of type 2 immune response (GO:0002830)2.56478473
115regulation of RIG-I signaling pathway (GO:0039535)2.55569834
116negative regulation of lipid storage (GO:0010888)2.55550153
117regulation of T cell tolerance induction (GO:0002664)2.53905487
118dendritic cell differentiation (GO:0097028)2.49996341
119regulation of fibroblast apoptotic process (GO:2000269)2.49263041
120immunoglobulin mediated immune response (GO:0016064)2.48665254
121positive regulation of natural killer cell differentiation (GO:0032825)2.48619168
122cell adhesion mediated by integrin (GO:0033627)2.46200959
123cytokine secretion (GO:0050663)2.45321700
124natural killer cell mediated immunity (GO:0002228)2.42472277
125natural killer cell mediated cytotoxicity (GO:0042267)2.42472277
126regulation of B cell receptor signaling pathway (GO:0050855)2.42206854
127lipopolysaccharide-mediated signaling pathway (GO:0031663)2.40287562
128lymphocyte chemotaxis (GO:0048247)2.40170785
129JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.39819665
130interferon-gamma secretion (GO:0072643)2.39762141
131wound healing, spreading of epidermal cells (GO:0035313)2.36398349
132response to host (GO:0075136)2.35130061
133response to host defenses (GO:0052200)2.35130061
134response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.35130061
135T cell activation involved in immune response (GO:0002286)2.35039520
136superoxide anion generation (GO:0042554)2.32775955
137cellular response to growth hormone stimulus (GO:0071378)2.31499540
138negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.30339076
139response to protozoan (GO:0001562)2.29909426
140positive regulation of monocyte chemotaxis (GO:0090026)2.29216591
141regulation of germinal center formation (GO:0002634)2.28799727
142positive regulation of heat generation (GO:0031652)2.28665851
143positive regulation of interferon-beta production (GO:0032728)2.28529594
144G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.28245815
145positive regulation of p38MAPK cascade (GO:1900745)2.28216054
146nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.27216901
147regulation of interleukin-12 production (GO:0032655)2.26877086
148establishment of endothelial barrier (GO:0061028)2.25952586
149detection of molecule of bacterial origin (GO:0032490)2.25536327
150tolerance induction (GO:0002507)2.25410038
151response to laminar fluid shear stress (GO:0034616)2.24968736
152positive regulation of toll-like receptor signaling pathway (GO:0034123)2.23386279
153positive regulation of acute inflammatory response (GO:0002675)2.23035990
154regulation of mononuclear cell migration (GO:0071675)2.22507493
155cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.22070241
156regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.21989074
157positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.21937820
158negative regulation of granulocyte differentiation (GO:0030853)2.21802195
159alpha-beta T cell activation involved in immune response (GO:0002287)2.21467395
160T cell differentiation involved in immune response (GO:0002292)2.21467395

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.02942139
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.74728046
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.71220575
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.21469685
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.52506970
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.48905880
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.37545246
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.10510158
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.97197123
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.87392267
11* IRF8_27001747_Chip-Seq_BMDM_Mouse2.82269033
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.81545964
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.75658446
14* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.70200107
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.53001312
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.44116250
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42919844
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.41239863
19RUNX_20019798_ChIP-Seq_JUKART_Human2.35514944
20* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.34059881
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.22139013
22* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.04503101
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00107245
24STAT4_19710469_ChIP-ChIP_TH1__Mouse1.99621112
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.97693809
26* GATA2_21666600_ChIP-Seq_HMVEC_Human1.97508311
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89572722
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.89182370
29* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.79934469
30* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.76983340
31* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.76983340
32* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74975962
33VDR_24787735_ChIP-Seq_THP-1_Human1.72845638
34* UTX_26944678_Chip-Seq_JUKART_Human1.71125709
35SCL_19346495_ChIP-Seq_HPC-7_Human1.68843375
36* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66075256
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65920789
38CJUN_26792858_Chip-Seq_BT549_Human1.65052917
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.58723433
40FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.57131317
41* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.54238558
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.51479129
43VDR_21846776_ChIP-Seq_THP-1_Human1.47689934
44* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47482279
45* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47014801
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46583954
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.43706362
48* MYB_26560356_Chip-Seq_TH2_Human1.43631969
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42414364
50CLOCK_20551151_ChIP-Seq_293T_Human1.40509319
51SPI1_23127762_ChIP-Seq_K562_Human1.39958445
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39590905
53SOX2_20726797_ChIP-Seq_SW620_Human1.39376968
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39345540
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38973330
56GATA1_22025678_ChIP-Seq_K562_Human1.37278594
57PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35949223
58* FOXO3_23340844_ChIP-Seq_DLD1_Human1.35452699
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34972043
60* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32812630
61* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32812630
62MYC_22102868_ChIP-Seq_BL_Human1.32282811
63PU_27001747_Chip-Seq_BMDM_Mouse1.29987181
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29619400
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26009367
66* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25141762
67RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24919224
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24666376
69* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24179344
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.23862355
71MAF_26560356_Chip-Seq_TH2_Human1.22198618
72TP53_18474530_ChIP-ChIP_U2OS_Human1.21495562
73* MAF_26560356_Chip-Seq_TH1_Human1.21354878
74* MYB_26560356_Chip-Seq_TH1_Human1.20470875
75CDX2_20551321_ChIP-Seq_CACO-2_Human1.17363076
76GATA1_19941826_ChIP-Seq_K562_Human1.16382822
77* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16291332
78* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15094200
79* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13909566
80* KDM2B_26808549_Chip-Seq_DND41_Human1.13110521
81* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12674161
82VDR_24763502_ChIP-Seq_THP-1_Human1.10203860
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.09934262
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09311312
85CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08462761
86* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06922298
87GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05864611
88SPI1_23547873_ChIP-Seq_NB4_Human1.05525634
89GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04514003
90* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04411996
91TP53_16413492_ChIP-PET_HCT116_Human1.02977530
92* RUNX1_22412390_ChIP-Seq_EML_Mouse1.02646521
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01916109
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01916109
95KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01916109
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01388268
97* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01324278
98AHR_22903824_ChIP-Seq_MCF-7_Human1.00899690
99RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00032323
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99065338
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98640268
102* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97936609
103BRD4_25478319_ChIP-Seq_HGPS_Human0.96129828
104GATA3_27048872_Chip-Seq_THYMUS_Human0.95084872
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93520375
106* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93307582
107SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92610112
108* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92458862
109P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91899766
110GATA1_19941827_ChIP-Seq_MEL_Mouse0.90246049
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89552986
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88544715
113GATA3_26560356_Chip-Seq_TH2_Human0.86983624
114* TCF7_22412390_ChIP-Seq_EML_Mouse0.85845102
115* TP63_23658742_ChIP-Seq_EP156T_Human0.85751855
116AR_21572438_ChIP-Seq_LNCaP_Human0.85132273
117KLF5_25053715_ChIP-Seq_YYC3_Human0.83265310
118* RXR_22108803_ChIP-Seq_LS180_Human0.80825606
119* GATA2_19941826_ChIP-Seq_K562_Human0.80044732
120* KDM2B_26808549_Chip-Seq_JURKAT_Human0.79198709
121* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79190467
122* LXR_22158963_ChIP-Seq_LIVER_Mouse0.78505144
123* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78409164
124VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.78215680
125* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77717999
126PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77480610
127FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.77291448
128* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.77124213
129CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.77101929
130* UBF1/2_26484160_Chip-Seq_HMECs_Human0.76986319
131* ELK3_25401928_ChIP-Seq_HUVEC_Human0.76646130
132EGR1_19032775_ChIP-ChIP_M12_Human0.76352270
133PPARA_22158963_ChIP-Seq_LIVER_Mouse0.76328415
134* SMRT_27268052_Chip-Seq_Bcells_Human0.75402876

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.38555338
2MP0002254_reproductive_system_inflammat3.37287951
3MP0003436_decreased_susceptibility_to3.11867299
4MP0003724_increased_susceptibility_to2.91211920
5MP0002148_abnormal_hypersensitivity_rea2.59758407
6MP0009785_altered_susceptibility_to2.52448752
7MP0005000_abnormal_immune_tolerance2.47566815
8MP0005387_immune_system_phenotype2.32751014
9MP0001790_abnormal_immune_system2.32751014
10MP0002419_abnormal_innate_immunity2.32448214
11MP0002452_abnormal_antigen_presenting2.18020559
12MP0006082_CNS_inflammation2.16673506
13MP0003303_peritoneal_inflammation2.16241244
14MP0000685_abnormal_immune_system2.16145880
15MP0005671_abnormal_response_to2.15937517
16MP0002877_abnormal_melanocyte_morpholog2.12244047
17MP0001800_abnormal_humoral_immune2.08397004
18MP0001533_abnormal_skeleton_physiology2.04702674
19MP0004510_myositis2.01709373
20MP0002723_abnormal_immune_serum1.97518219
21MP0005025_abnormal_response_to1.95469906
22MP0004947_skin_inflammation1.94580150
23MP0002405_respiratory_system_inflammati1.93848788
24MP0001853_heart_inflammation1.90954433
25MP0009278_abnormal_bone_marrow1.83388825
26MP0002009_preneoplasia1.83079009
27MP0001819_abnormal_immune_cell1.82305461
28MP0002420_abnormal_adaptive_immunity1.82117718
29MP0003828_pulmonary_edema1.81537115
30MP0002166_altered_tumor_susceptibility1.79186996
31MP0002006_tumorigenesis1.76485522
32MP0001346_abnormal_lacrimal_gland1.74930577
33MP0003566_abnormal_cell_adhesion1.73844414
34MP0003448_altered_tumor_morphology1.65618277
35MP0002277_abnormal_respiratory_mucosa1.64991010
36MP0003453_abnormal_keratinocyte_physiol1.62686952
37MP0010155_abnormal_intestine_physiology1.60922281
38MP0005464_abnormal_platelet_physiology1.58630486
39MP0001851_eye_inflammation1.56457286
40MP0003300_gastrointestinal_ulcer1.51390912
41MP0002998_abnormal_bone_remodeling1.48216783
42MP0003763_abnormal_thymus_physiology1.48039577
43MP0003866_abnormal_defecation1.46181465
44MP0005397_hematopoietic_system_phenotyp1.43301888
45MP0001545_abnormal_hematopoietic_system1.43301888
46MP0001501_abnormal_sleep_pattern1.42101692
47MP0003091_abnormal_cell_migration1.36552100
48MP0005390_skeleton_phenotype1.34862050
49MP0003656_abnormal_erythrocyte_physiolo1.34518119
50MP0001845_abnormal_inflammatory_respons1.34389381
51MP0003279_aneurysm1.32747931
52MP0004808_abnormal_hematopoietic_stem1.31865148
53MP0002396_abnormal_hematopoietic_system1.31809118
54MP0000703_abnormal_thymus_morphology1.31642436
55MP0000343_altered_response_to1.30605607
56MP0002138_abnormal_hepatobiliary_system1.30187651
57MP0003941_abnormal_skin_development1.28550833
58MP0005164_abnormal_response_to1.27181773
59MP0002060_abnormal_skin_morphology1.25980507
60MP0000716_abnormal_immune_system1.24563343
61MP0002933_joint_inflammation1.23314842
62MP0001873_stomach_inflammation1.22236078
63MP0000858_altered_metastatic_potential1.20470775
64MP0010352_gastrointestinal_tract_polyps1.19843040
65MP0008438_abnormal_cutaneous_collagen1.19711013
66MP0005076_abnormal_cell_differentiation1.19559348
67MP0005023_abnormal_wound_healing1.19269269
68MP0009764_decreased_sensitivity_to1.18914196
69MP0004883_abnormal_blood_vessel1.18697210
70MP0009840_abnormal_foam_cell1.17855809
71MP0002398_abnormal_bone_marrow1.16894976
72MP0001879_abnormal_lymphatic_vessel1.15046434
73MP0000383_abnormal_hair_follicle1.13327700
74MP0004782_abnormal_surfactant_physiolog1.10317461
75MP0005310_abnormal_salivary_gland1.05287412
76MP0010368_abnormal_lymphatic_system1.04635582
77MP0001216_abnormal_epidermal_layer1.01993904
78MP0004381_abnormal_hair_follicle0.99352320
79MP0009333_abnormal_splenocyte_physiolog0.98732628
80MP0001958_emphysema0.98556399
81MP0005275_abnormal_skin_tensile0.98290926
82MP0005058_abnormal_lysosome_morphology0.98234747
83MP0003045_fibrosis0.96851389
84MP0003172_abnormal_lysosome_physiology0.96258281
85MP0003075_altered_response_to0.96246024
86MP0000767_abnormal_smooth_muscle0.95497303
87* MP0002429_abnormal_blood_cell0.93306085
88MP0002722_abnormal_immune_system0.92183240
89MP0008961_abnormal_basal_metabolism0.91879406
90MP0000689_abnormal_spleen_morphology0.90666451
91MP0000465_gastrointestinal_hemorrhage0.90305314
92MP0005166_decreased_susceptibility_to0.89795476
93MP0000249_abnormal_blood_vessel0.89450235
94MP0008469_abnormal_protein_level0.87604901
95MP0002132_abnormal_respiratory_system0.87496094
96MP0001191_abnormal_skin_condition0.87481412
97MP0003795_abnormal_bone_structure0.86789938
98MP0010678_abnormal_skin_adnexa0.86375458
99MP0001542_abnormal_bone_strength0.86321138
100MP0000604_amyloidosis0.82992646
101MP0002098_abnormal_vibrissa_morphology0.81892635
102MP0004484_altered_response_of0.81594695
103MP0009763_increased_sensitivity_to0.81429921
104MP0003191_abnormal_cellular_cholesterol0.78614977
105MP0004272_abnormal_basement_membrane0.77743187
106MP0002876_abnormal_thyroid_physiology0.74702238
107MP0002928_abnormal_bile_duct0.74128398
108MP0003252_abnormal_bile_duct0.73752427
109MP0002295_abnormal_pulmonary_circulatio0.73370750
110MP0008007_abnormal_cellular_replicative0.72997131
111MP0005257_abnormal_intraocular_pressure0.72544261
112MP0001243_abnormal_dermal_layer0.71535933
113MP0000569_abnormal_digit_pigmentation0.71532196
114MP0003950_abnormal_plasma_membrane0.66838291
115MP0003183_abnormal_peptide_metabolism0.66668287
116MP0008004_abnormal_stomach_pH0.66582148
117MP0002136_abnormal_kidney_physiology0.61962201
118MP0001663_abnormal_digestive_system0.61413069
119MP0005167_abnormal_blood-brain_barrier0.55738886
120MP0002133_abnormal_respiratory_system0.55390998
121MP0005388_respiratory_system_phenotype0.55390998
122MP0001986_abnormal_taste_sensitivity0.53788126
123MP0005165_increased_susceptibility_to0.52442493

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.13309001
2Recurrent abscess formation (HP:0002722)4.53753841
3Recurrent bacterial skin infections (HP:0005406)4.07625857
4T lymphocytopenia (HP:0005403)3.96469702
5IgG deficiency (HP:0004315)3.79546471
6Panhypogammaglobulinemia (HP:0003139)3.78110628
7Orchitis (HP:0100796)3.77322684
8Abnormal delayed hypersensitivity skin test (HP:0002963)3.76855808
9Optic neuritis (HP:0100653)3.72475689
10Retrobulbar optic neuritis (HP:0100654)3.72475689
11Myositis (HP:0100614)3.60253345
12Abnormality of B cell number (HP:0010975)3.59358555
13Abnormality of T cells (HP:0002843)3.52113444
14Severe combined immunodeficiency (HP:0004430)3.39343325
15Thick nail (HP:0001805)3.38209602
16Mediastinal lymphadenopathy (HP:0100721)3.37350942
17B lymphocytopenia (HP:0010976)3.32779490
18Granulocytopenia (HP:0001913)3.25332161
19Abnormality of T cell physiology (HP:0011840)3.22228207
20Elevated erythrocyte sedimentation rate (HP:0003565)3.19614613
21Osteolytic defects of the phalanges of the hand (HP:0009771)3.14778494
22Osteolytic defects of the hand bones (HP:0009699)3.14778494
23Recurrent fungal infections (HP:0002841)3.07959757
24Agammaglobulinemia (HP:0004432)3.06212830
25Abnormality of macrophages (HP:0004311)3.02419483
26Increased neuronal autofluorescent lipopigment (HP:0002074)2.83045551
27Distal lower limb muscle weakness (HP:0009053)2.76368645
28Vasculitis (HP:0002633)2.73818600
29Recurrent bronchitis (HP:0002837)2.70564503
30Increased cerebral lipofuscin (HP:0011813)2.66705315
31Systemic lupus erythematosus (HP:0002725)2.64607604
32Hematochezia (HP:0002573)2.62860163
33Recurrent skin infections (HP:0001581)2.61914556
34Myocardial infarction (HP:0001658)2.60436641
35Encephalitis (HP:0002383)2.55124788
36Spondylolisthesis (HP:0003302)2.51885419
37Recurrent gram-negative bacterial infections (HP:0005420)2.49808484
38Joint swelling (HP:0001386)2.49093757
39Pulmonary infiltrates (HP:0002113)2.48769504
40Abnormality of the nasal septum (HP:0000419)2.48561537
41Vacuolated lymphocytes (HP:0001922)2.47871208
42Obstructive lung disease (HP:0006536)2.45846316
43Chronic obstructive pulmonary disease (HP:0006510)2.45846316
44Gingivitis (HP:0000230)2.44253291
45Interstitial pulmonary disease (HP:0006530)2.44061987
46Keratoconjunctivitis sicca (HP:0001097)2.43968805
47Combined immunodeficiency (HP:0005387)2.43935263
48Keratoconjunctivitis (HP:0001096)2.40960372
49Growth hormone excess (HP:0000845)2.40696361
50Cellulitis (HP:0100658)2.40313523
51Papilloma (HP:0012740)2.39689175
52Verrucae (HP:0200043)2.39689175
53Thyroiditis (HP:0100646)2.38228608
54Abnormality of the pleura (HP:0002103)2.37926881
55Epistaxis (HP:0000421)2.37438512
56Pulmonary fibrosis (HP:0002206)2.36626729
57Chest pain (HP:0100749)2.36228313
58Recurrent cutaneous fungal infections (HP:0011370)2.36225299
59Chronic mucocutaneous candidiasis (HP:0002728)2.36225299
60Pustule (HP:0200039)2.34280371
61Anhidrosis (HP:0000970)2.32018878
62Arterial thrombosis (HP:0004420)2.30547520
63Stomatitis (HP:0010280)2.29252053
64Persistence of primary teeth (HP:0006335)2.28045965
65Dysostosis multiplex (HP:0000943)2.27433021
66Amyloidosis (HP:0011034)2.27311160
67Increased IgE level (HP:0003212)2.25294953
68Periodontitis (HP:0000704)2.24721985
69Urticaria (HP:0001025)2.22289398
70Gangrene (HP:0100758)2.22226333
71Alveolar cell carcinoma (HP:0006519)2.21435697
72Recurrent viral infections (HP:0004429)2.20974748
73Pulmonary embolism (HP:0002204)2.19170617
74Autoimmune thrombocytopenia (HP:0001973)2.18819351
75Chronic otitis media (HP:0000389)2.15730038
76Milia (HP:0001056)2.15669584
77Alopecia of scalp (HP:0002293)2.14017739
78Gastrointestinal inflammation (HP:0004386)2.13111035
79Episodic fever (HP:0001954)2.12208546
80Increased IgM level (HP:0003496)2.10779727
81Leukocytosis (HP:0001974)2.09185378
82Gingival bleeding (HP:0000225)2.06616781
83Spontaneous hematomas (HP:0007420)2.05053586
84Hemoptysis (HP:0002105)2.04496352
85Spinal cord lesions (HP:0100561)2.03360704
86Syringomyelia (HP:0003396)2.03360704
87Lip pit (HP:0100267)2.02969683
88Eosinophilia (HP:0001880)2.02309222
89Conical tooth (HP:0000698)2.01996480
90Neoplasm of the tracheobronchial system (HP:0100552)2.01783530
91Osteomyelitis (HP:0002754)2.01342990
92Gastrointestinal infarctions (HP:0005244)2.00898046
93Arthralgia (HP:0002829)2.00572938
94Atrophic scars (HP:0001075)2.00432835
95Urethral obstruction (HP:0000796)1.99648901
96Submucous cleft hard palate (HP:0000176)1.98411405
97Gastrointestinal stroma tumor (HP:0100723)1.98060681
98Tetraparesis (HP:0002273)1.94571539
99Restrictive lung disease (HP:0002091)1.93712601
100Hypergammaglobulinemia (HP:0010702)1.93245921
101Abnormality of the frontal sinuses (HP:0002687)1.92898063
102Abnormality of glycolipid metabolism (HP:0010969)1.92682827
103Abnormality of liposaccharide metabolism (HP:0010968)1.92682827
104Abnormality of glycosphingolipid metabolism (HP:0004343)1.92682827
105Recurrent pneumonia (HP:0006532)1.91883592
106Pulmonary artery stenosis (HP:0004415)1.90794380
107Meningitis (HP:0001287)1.90248804
108Prolonged bleeding time (HP:0003010)1.90222114
109Polygenic inheritance (HP:0010982)1.89572627
110Premature rupture of membranes (HP:0001788)1.89509466
111Glomerulopathy (HP:0100820)1.88446459
112Glucose intolerance (HP:0000833)1.87982878
113Sepsis (HP:0100806)1.87729484
114Skin rash (HP:0000988)1.87602145
115Abnormality of the pericardium (HP:0001697)1.87351409
116Lymphopenia (HP:0001888)1.87008098
117Abnormality of the distal phalanges of the toes (HP:0010182)1.86827310
118Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86261037
119Cheilitis (HP:0100825)1.85939171
120Basal ganglia calcification (HP:0002135)1.85444932
121Xerostomia (HP:0000217)1.84996444
122Acute myeloid leukemia (HP:0004808)1.83162391
123Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82422854
124Vertebral compression fractures (HP:0002953)1.78796267
125Abnormality of T cell number (HP:0011839)1.78770966
126Plantar hyperkeratosis (HP:0007556)1.78245578
127Segmental peripheral demyelination/remyelination (HP:0003481)1.78208887
128Abnormality of eosinophils (HP:0001879)1.77503254
129Autoimmune hemolytic anemia (HP:0001890)1.77456598
130Skin ulcer (HP:0200042)1.77107321
131Aplasia cutis congenita (HP:0001057)1.76124933
132* Stomach cancer (HP:0012126)1.76099863
133Absent frontal sinuses (HP:0002688)1.75848172
134Petechiae (HP:0000967)1.73860328
135Axonal loss (HP:0003447)1.73789334
136Inflammation of the large intestine (HP:0002037)1.72752021
137Distal lower limb amyotrophy (HP:0008944)1.72536248
138Porencephaly (HP:0002132)1.72320573
139Esophageal varix (HP:0002040)1.71237015
140Colitis (HP:0002583)1.70928464
141Recurrent lower respiratory tract infections (HP:0002783)1.68139814
142Short nail (HP:0001799)1.67127368
143Bone pain (HP:0002653)1.66269031
144* Prostate neoplasm (HP:0100787)1.65785188
145Chronic diarrhea (HP:0002028)1.65591452

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.80779952
2GRK62.79020109
3MAPK152.72396522
4TYK22.59915065
5IKBKB2.57623847
6TBK12.41002099
7TGFBR22.34704674
8IRAK42.34611531
9MAP3K32.28482194
10IKBKE2.28348370
11EPHB12.26024746
12PIK3CG2.22511018
13MST42.19300054
14IRAK32.16969576
15TXK2.11137190
16EPHA32.09821015
17CHUK2.06018978
18JAK32.04682330
19JAK11.93768551
20FES1.84775979
21KIT1.70006044
22STK101.58899849
23RPS6KA41.55202241
24TEC1.54857434
25PIM21.53762477
26NEK91.50325806
27PRPF4B1.43795751
28ITK1.41749618
29MAP2K21.40408504
30MAP4K11.40144143
31ERN11.37248893
32NLK1.36502437
33MAP2K31.33386265
34PBK1.27957406
35EPHA21.26849540
36FGFR31.24553057
37NUAK11.24372199
38TRPM71.23957863
39RIPK41.18768632
40BMPR1B1.17192225
41FGFR41.17026742
42BLK1.10429149
43FRK1.06215227
44BMPR21.06058857
45CSK1.05656175
46PIM11.05420382
47TNK21.04699712
48BTK1.02818871
49TGFBR11.02624114
50IRAK10.99942295
51HCK0.98366630
52ERBB30.98314339
53GRK70.96703455
54EIF2AK20.96334962
55TIE10.96027824
56PIK3CA0.90747171
57TESK20.89835160
58CSF1R0.86615302
59SIK30.84999422
60LCK0.84259521
61ZAK0.83664404
62ZAP700.82286069
63MST1R0.81418853
64MAP3K70.81409640
65MAPKAPK20.80032743
66MATK0.78951812
67MAP3K20.78938190
68MAP3K10.78927287
69MAPKAPK50.78644636
70STK240.75050047
71MAP3K130.74571827
72RPS6KA20.72717651
73RPS6KA50.70482687
74MAPK40.69083263
75MAPK70.68801032
76JAK20.68642543
77CDK120.65932913
78SYK0.65612505
79RPS6KC10.65075765
80RPS6KL10.65075765
81RIPK10.64907299
82CDK60.64880453
83MAPK120.64325873
84CDK80.63756916
85HIPK20.63091628
86MAPKAPK30.62247415
87CLK10.61094454
88PTK60.60668990
89GSK3A0.58563232
90STK30.58480581
91PRKD20.58381202
92MAP2K10.55921892
93PDGFRB0.55568464
94PRKG20.54194888
95PDK10.53711193
96ABL10.53635182
97MAP3K100.52481268
98RPS6KA60.52298552
99TTN0.51499598
100TAOK30.50928242
101DMPK0.50623564
102STK40.50317827
103VRK10.49560434
104EPHB20.49480582
105RPS6KB20.49402928
106LYN0.48951860
107MAPK30.48668579
108MAPK110.46975329
109MAP3K110.46731370
110MARK30.45826425
111TSSK60.45748596
112MARK20.45380882
113SIK20.43256354
114IRAK20.43065613
115PRKCD0.42415819
116BMX0.41804955
117IGF1R0.41021902
118RPS6KA10.40696939
119FER0.40524000
120KDR0.39466336
121ADRBK20.38963174
122PRKCQ0.38487174
123MOS0.37812915
124LRRK20.37320938
125PTK2B0.37199864
126MAP3K60.37070527
127CDC42BPA0.36738353
128NEK60.36353354
129FLT30.36087305
130PDK20.34874038
131TAOK20.33196590
132PDPK10.32337281

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.64926872
2Graft-versus-host disease_Homo sapiens_hsa053322.43425756
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.40824399
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.37836916
5Osteoclast differentiation_Homo sapiens_hsa043802.31307145
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.23420167
7TNF signaling pathway_Homo sapiens_hsa046682.10665077
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.01402419
9Measles_Homo sapiens_hsa051621.99226440
10NOD-like receptor signaling pathway_Homo sapiens_hsa046211.95469687
11Toxoplasmosis_Homo sapiens_hsa051451.93196648
12Allograft rejection_Homo sapiens_hsa053301.88194623
13Malaria_Homo sapiens_hsa051441.87722388
14Pertussis_Homo sapiens_hsa051331.82574136
15Legionellosis_Homo sapiens_hsa051341.78293810
16Rheumatoid arthritis_Homo sapiens_hsa053231.71275750
17B cell receptor signaling pathway_Homo sapiens_hsa046621.60831054
18Influenza A_Homo sapiens_hsa051641.60759062
19Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.58258251
20Hematopoietic cell lineage_Homo sapiens_hsa046401.57127254
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.55425813
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54516595
23Apoptosis_Homo sapiens_hsa042101.53584132
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.52983135
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.52934682
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43706777
27Antigen processing and presentation_Homo sapiens_hsa046121.37895214
28Staphylococcus aureus infection_Homo sapiens_hsa051501.36486921
29Tuberculosis_Homo sapiens_hsa051521.34070967
30Salmonella infection_Homo sapiens_hsa051321.34029938
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.33934822
32T cell receptor signaling pathway_Homo sapiens_hsa046601.25187837
33African trypanosomiasis_Homo sapiens_hsa051431.24735571
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22764194
35Chemokine signaling pathway_Homo sapiens_hsa040621.22429943
36Autoimmune thyroid disease_Homo sapiens_hsa053201.22023884
37Hepatitis B_Homo sapiens_hsa051611.20572819
38Herpes simplex infection_Homo sapiens_hsa051681.19492558
39Shigellosis_Homo sapiens_hsa051311.18971611
40Small cell lung cancer_Homo sapiens_hsa052221.18209939
41Viral myocarditis_Homo sapiens_hsa054161.15287878
42Primary immunodeficiency_Homo sapiens_hsa053401.14885609
43Hepatitis C_Homo sapiens_hsa051601.12524776
44Acute myeloid leukemia_Homo sapiens_hsa052211.10128935
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06472557
46Asthma_Homo sapiens_hsa053101.06119739
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04649518
48Dorso-ventral axis formation_Homo sapiens_hsa043201.03679911
49ECM-receptor interaction_Homo sapiens_hsa045121.02731264
50Phagosome_Homo sapiens_hsa041451.01137637
51Chronic myeloid leukemia_Homo sapiens_hsa052201.00857899
52Prolactin signaling pathway_Homo sapiens_hsa049170.99844165
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99839864
54Amoebiasis_Homo sapiens_hsa051460.99834277
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90754508
56Platelet activation_Homo sapiens_hsa046110.90548059
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89193843
58Adherens junction_Homo sapiens_hsa045200.87917615
59Pancreatic cancer_Homo sapiens_hsa052120.86652354
60Focal adhesion_Homo sapiens_hsa045100.84342889
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83854518
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.81709653
63Prostate cancer_Homo sapiens_hsa052150.81075716
64Lysosome_Homo sapiens_hsa041420.80722644
65HTLV-I infection_Homo sapiens_hsa051660.79051685
66Proteoglycans in cancer_Homo sapiens_hsa052050.77791422
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76237626
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75590967
69Type I diabetes mellitus_Homo sapiens_hsa049400.70887623
70MicroRNAs in cancer_Homo sapiens_hsa052060.66781474
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65663183
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64633173
73Other glycan degradation_Homo sapiens_hsa005110.63956912
74Circadian rhythm_Homo sapiens_hsa047100.63940890
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63530403
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63365050
77TGF-beta signaling pathway_Homo sapiens_hsa043500.63317235
78FoxO signaling pathway_Homo sapiens_hsa040680.62342240
79Non-small cell lung cancer_Homo sapiens_hsa052230.61503327
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58741212
81Pathways in cancer_Homo sapiens_hsa052000.58638169
82HIF-1 signaling pathway_Homo sapiens_hsa040660.55893620
83Epstein-Barr virus infection_Homo sapiens_hsa051690.55182139
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.54541103
85Choline metabolism in cancer_Homo sapiens_hsa052310.54130048
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53894323
87Notch signaling pathway_Homo sapiens_hsa043300.53436056
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53335183
89Colorectal cancer_Homo sapiens_hsa052100.53275328
90Arachidonic acid metabolism_Homo sapiens_hsa005900.52834674
91Viral carcinogenesis_Homo sapiens_hsa052030.52375135
92MAPK signaling pathway_Homo sapiens_hsa040100.51875470
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.51359468
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50980548
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50827343
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50562509
97Renal cell carcinoma_Homo sapiens_hsa052110.47719152
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46724898
99Rap1 signaling pathway_Homo sapiens_hsa040150.45500345
100Sphingolipid metabolism_Homo sapiens_hsa006000.44125128
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.43894031
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43337338
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42973345
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.42696513
105Endocytosis_Homo sapiens_hsa041440.42464570
106VEGF signaling pathway_Homo sapiens_hsa043700.41998161
107Insulin resistance_Homo sapiens_hsa049310.41990618
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41419278
109p53 signaling pathway_Homo sapiens_hsa041150.40622185
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40495612
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40165853
112GnRH signaling pathway_Homo sapiens_hsa049120.40007936
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39778898
114Melanoma_Homo sapiens_hsa052180.39590471
115Linoleic acid metabolism_Homo sapiens_hsa005910.36410332
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36174180
117Estrogen signaling pathway_Homo sapiens_hsa049150.36174126
118Renin secretion_Homo sapiens_hsa049240.35940533
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32271752
120Complement and coagulation cascades_Homo sapiens_hsa046100.30499024
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.30320788
122Nitrogen metabolism_Homo sapiens_hsa009100.29895024

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