ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cell wall macromolecule catabolic process (GO:0016998)	8.06986181
2	cell wall macromolecule metabolic process (GO:0044036)	6.74502637
3	heparin biosynthetic process (GO:0030210)	6.39948178
4	heparin metabolic process (GO:0030202)	6.39948178
5	aggressive behavior (GO:0002118)	5.72531748
6	pyrimidine nucleobase catabolic process (GO:0006208)	4.79819165
7	activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)	4.47718816
8	base-excision repair, AP site formation (GO:0006285)	4.47679016
9	positive regulation of catecholamine secretion (GO:0033605)	4.41272479
10	negative regulation of JAK-STAT cascade (GO:0046426)	4.16080961
11	positive regulation of mitochondrial fission (GO:0090141)	4.14212109
12	sequestering of actin monomers (GO:0042989)	4.13959742
13	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.11427745
14	seminiferous tubule development (GO:0072520)	3.92167051
15	gamma-aminobutyric acid transport (GO:0015812)	3.91929150
16	histone H2A acetylation (GO:0043968)	3.91773673
17	nucleobase catabolic process (GO:0046113)	3.85025332
18	neurofilament cytoskeleton organization (GO:0060052)	3.84939009
19	cellular response to exogenous dsRNA (GO:0071360)	3.83861955
20	piRNA metabolic process (GO:0034587)	3.80605998
21	nitric oxide mediated signal transduction (GO:0007263)	3.76247147
22	mRNA modification (GO:0016556)	3.69657486
23	negative regulation of telomere maintenance (GO:0032205)	3.59223989
24	RNA destabilization (GO:0050779)	3.58687352
25	positive regulation of prostaglandin secretion (GO:0032308)	3.30548486
26	negative regulation of mast cell activation (GO:0033004)	3.29424574
27	regulation of penile erection (GO:0060405)	3.28783188
28	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.22908493
29	negative regulation of oligodendrocyte differentiation (GO:0048715)	3.16286794
30	behavioral response to ethanol (GO:0048149)	3.13014461
31	auditory receptor cell stereocilium organization (GO:0060088)	3.08636534
32	DNA methylation involved in gamete generation (GO:0043046)	3.07952096
33	negative regulation of neurological system process (GO:0031645)	3.05471047
34	vitamin transmembrane transport (GO:0035461)	3.02923172
35	regulation of mitochondrial fission (GO:0090140)	2.99656344
36	GMP metabolic process (GO:0046037)	2.99559754
37	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.99295751
38	positive regulation of fatty acid transport (GO:2000193)	2.97896282
39	positive regulation of vasculogenesis (GO:2001214)	2.96148590
40	response to ATP (GO:0033198)	2.92518673
41	cellular response to ATP (GO:0071318)	2.91165712
42	protein-cofactor linkage (GO:0018065)	2.89875426
43	parental behavior (GO:0060746)	2.89093238
44	response to pheromone (GO:0019236)	2.88519610
45	positive regulation of receptor internalization (GO:0002092)	2.85415939
46	epithelial cell differentiation involved in kidney development (GO:0035850)	2.84879500
47	regulation of feeding behavior (GO:0060259)	2.84340675
48	tryptophan catabolic process (GO:0006569)	2.84304682
49	indole-containing compound catabolic process (GO:0042436)	2.84304682
50	indolalkylamine catabolic process (GO:0046218)	2.84304682
51	aspartate family amino acid catabolic process (GO:0009068)	2.84117100
52	regulation of centriole replication (GO:0046599)	2.83634979
53	dendrite morphogenesis (GO:0048813)	2.83473600
54	retinal cone cell development (GO:0046549)	2.83410187
55	inner ear receptor stereocilium organization (GO:0060122)	2.80187101
56	regulation of female receptivity (GO:0045924)	2.78818441
57	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.78489520
58	positive regulation of synapse assembly (GO:0051965)	2.76888538
59	sleep (GO:0030431)	2.75052107
60	DNA double-strand break processing (GO:0000729)	2.74660571
61	regulation of prostaglandin secretion (GO:0032306)	2.73926748
62	kynurenine metabolic process (GO:0070189)	2.73605181
63	GPI anchor metabolic process (GO:0006505)	2.71715400
64	glial cell proliferation (GO:0014009)	2.71164617
65	indolalkylamine metabolic process (GO:0006586)	2.70757547
66	rRNA methylation (GO:0031167)	2.69016341
67	negative regulation of digestive system process (GO:0060457)	2.68972492
68	positive regulation of icosanoid secretion (GO:0032305)	2.68005341
69	negative regulation of meiotic cell cycle (GO:0051447)	2.67924855
70	maternal behavior (GO:0042711)	2.67518443
71	protein insertion into membrane (GO:0051205)	2.64038559
72	mannosylation (GO:0097502)	2.63929385
73	L-fucose catabolic process (GO:0042355)	2.63918417
74	fucose catabolic process (GO:0019317)	2.63918417
75	L-fucose metabolic process (GO:0042354)	2.63918417
76	establishment of mitochondrion localization (GO:0051654)	2.61914444
77	regulation of oligodendrocyte differentiation (GO:0048713)	2.61625855
78	positive regulation of amine transport (GO:0051954)	2.60725815
79	cGMP biosynthetic process (GO:0006182)	2.59518698
80	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.59357797
81	behavioral response to nicotine (GO:0035095)	2.58724523
82	rRNA modification (GO:0000154)	2.57383390
83	positive regulation of interleukin-1 beta secretion (GO:0050718)	2.55583784
84	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.54186424
85	C4-dicarboxylate transport (GO:0015740)	2.53916438
86	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.49452109
87	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.48644674
88	respiratory chain complex IV assembly (GO:0008535)	2.47340415
89	negative regulation of heart rate (GO:0010459)	2.47184426
90	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.47182074
91	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.46945134
92	resolution of meiotic recombination intermediates (GO:0000712)	2.46943693
93	DNA deamination (GO:0045006)	2.46611265
94	cilium morphogenesis (GO:0060271)	2.43663345
95	protein sumoylation (GO:0016925)	2.42938790
96	intraciliary transport (GO:0042073)	2.42618887
97	relaxation of smooth muscle (GO:0044557)	2.42455820
98	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.42195308
99	ADP metabolic process (GO:0046031)	2.42057332
100	GPI anchor biosynthetic process (GO:0006506)	2.41412722

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.67299451
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.66971460
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.24964228
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.18419945
5	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.82961518
6	FUS_26573619_Chip-Seq_HEK293_Human	2.79015084
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.64551052
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.53398703
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.44862742
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.35228733
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.33214128
12	EWS_26573619_Chip-Seq_HEK293_Human	2.11921659
13	P300_19829295_ChIP-Seq_ESCs_Human	2.09173821
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.04605111
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.03734560
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.01615053
17	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.00580619
18	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.99094621
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.96826406
20	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.94726591
21	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.93670652
22	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.92736699
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.89446457
24	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.89441146
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.89423561
26	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.84292145
27	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.83893708
28	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.81140927
29	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.79398447
30	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.76665305
31	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.70279614
32	VDR_22108803_ChIP-Seq_LS180_Human	1.64592266
33	RNF2_27304074_Chip-Seq_NSC_Mouse	1.56718561
34	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.55162781
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53748480
36	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.52590753
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.47907147
38	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.47850919
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.47173008
40	SMAD4_21799915_ChIP-Seq_A2780_Human	1.46397573
41	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.45352257
42	VDR_23849224_ChIP-Seq_CD4+_Human	1.42672222
43	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.41090837
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39455467
45	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.39449145
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.37391193
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.37366896
48	CBP_20019798_ChIP-Seq_JUKART_Human	1.37366896
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.34217209
50	TCF4_23295773_ChIP-Seq_U87_Human	1.33692519
51	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.33084362
52	STAT3_23295773_ChIP-Seq_U87_Human	1.31999482
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29853621
54	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.23982155
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.23979650
56	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.22974407
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.21777894
58	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.19712552
59	AR_25329375_ChIP-Seq_VCAP_Human	1.19573882
60	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.19197799
61	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.18773854
62	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.18568962
63	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.17191601
64	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.16742940
65	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.16129103
66	AR_20517297_ChIP-Seq_VCAP_Human	1.14962537
67	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14568987
68	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.13061123
69	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.13040785
70	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.11679776
71	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10894111
72	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10894111
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.10599930
74	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.10206917
75	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.09484519
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.09150791
77	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.08312261
78	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.07727457
79	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.06703767
80	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.06703767
81	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.06110161
82	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.05252730
83	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.05202224
84	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.05131763
85	AR_21572438_ChIP-Seq_LNCaP_Human	1.04509843
86	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.02218959
87	MYC_18940864_ChIP-ChIP_HL60_Human	1.02075177
88	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01791155
89	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.01458737
90	RUNX2_22187159_ChIP-Seq_PCA_Human	1.01129607
91	BCAT_22108803_ChIP-Seq_LS180_Human	1.00480780
92	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99483852
93	CDX2_22108803_ChIP-Seq_LS180_Human	0.99257039
94	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.98678817
95	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97159486
96	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95812798
97	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.95297002
98	P53_22387025_ChIP-Seq_ESCs_Mouse	0.94368639
99	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.93430546
100	IRF1_19129219_ChIP-ChIP_H3396_Human	0.93286201

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005084_abnormal_gallbladder_morpholo	4.77103558
2	MP0003303_peritoneal_inflammation	4.14993295
3	MP0001986_abnormal_taste_sensitivity	3.78109503
4	MP0004270_analgesia	3.52837737
5	MP0003787_abnormal_imprinting	3.33296230
6	MP0002139_abnormal_hepatobiliary_system	3.33119623
7	MP0004147_increased_porphyrin_level	2.97592917
8	MP0006276_abnormal_autonomic_nervous	2.87398217
9	MP0002138_abnormal_hepatobiliary_system	2.67898393
10	MP0002928_abnormal_bile_duct	2.41434303
11	MP0002102_abnormal_ear_morphology	2.39322063
12	MP0001529_abnormal_vocalization	1.96010817
13	MP0008877_abnormal_DNA_methylation	1.89857589
14	MP0008004_abnormal_stomach_pH	1.89589966
15	MP0002734_abnormal_mechanical_nocicepti	1.87666486
16	MP0003880_abnormal_central_pattern	1.84792763
17	MP0003252_abnormal_bile_duct	1.75811492
18	MP0004142_abnormal_muscle_tone	1.71784817
19	MP0000569_abnormal_digit_pigmentation	1.68039254
20	MP0009046_muscle_twitch	1.64278850
21	MP0001968_abnormal_touch/_nociception	1.64084086
22	MP0002160_abnormal_reproductive_system	1.61788101
23	MP0003172_abnormal_lysosome_physiology	1.57185917
24	MP0005646_abnormal_pituitary_gland	1.55237907
25	MP0003806_abnormal_nucleotide_metabolis	1.55148332
26	MP0003121_genomic_imprinting	1.51164196
27	MP0002272_abnormal_nervous_system	1.49986981
28	MP0003011_delayed_dark_adaptation	1.48720032
29	MP0001984_abnormal_olfaction	1.48441507
30	MP0005085_abnormal_gallbladder_physiolo	1.48369999
31	MP0003724_increased_susceptibility_to	1.45459958
32	MP0001502_abnormal_circadian_rhythm	1.44832351
33	MP0005551_abnormal_eye_electrophysiolog	1.44351752
34	MP0001486_abnormal_startle_reflex	1.43449680
35	MP0001501_abnormal_sleep_pattern	1.39894191
36	MP0008875_abnormal_xenobiotic_pharmacok	1.39815240
37	MP0009745_abnormal_behavioral_response	1.39539509
38	MP0006054_spinal_hemorrhage	1.38246184
39	MP0002653_abnormal_ependyma_morphology	1.34811221
40	MP0002572_abnormal_emotion/affect_behav	1.32904973
41	MP0002735_abnormal_chemical_nociception	1.24649249
42	MP0008995_early_reproductive_senescence	1.23865594
43	MP0002733_abnormal_thermal_nociception	1.21578447
44	MP0000955_abnormal_spinal_cord	1.20244345
45	MP0002751_abnormal_autonomic_nervous	1.20156109
46	MP0002184_abnormal_innervation	1.19014354
47	MP0000230_abnormal_systemic_arterial	1.18884334
48	MP0000778_abnormal_nervous_system	1.17469181
49	MP0003635_abnormal_synaptic_transmissio	1.14814820
50	MP0002638_abnormal_pupillary_reflex	1.14195444
51	MP0008058_abnormal_DNA_repair	1.12207498
52	MP0001970_abnormal_pain_threshold	1.11971896
53	MP0003718_maternal_effect	1.11734595
54	MP0002736_abnormal_nociception_after	1.11635552
55	MP0000013_abnormal_adipose_tissue	1.09268297
56	MP0002282_abnormal_trachea_morphology	1.08684780
57	MP0002277_abnormal_respiratory_mucosa	1.08369035
58	MP0003633_abnormal_nervous_system	1.03241586
59	MP0005253_abnormal_eye_physiology	1.02235181
60	MP0005645_abnormal_hypothalamus_physiol	1.02194238
61	MP0003122_maternal_imprinting	1.01753408
62	MP0002234_abnormal_pharynx_morphology	1.00572621
63	MP0000467_abnormal_esophagus_morphology	0.99686860
64	MP0000372_irregular_coat_pigmentation	0.97440026
65	MP0002557_abnormal_social/conspecific_i	0.96778907
66	MP0002063_abnormal_learning/memory/cond	0.96411194
67	MP0005389_reproductive_system_phenotype	0.96365684
68	MP0006072_abnormal_retinal_apoptosis	0.93639790
69	MP0005367_renal/urinary_system_phenotyp	0.91934177
70	MP0000516_abnormal_urinary_system	0.91934177
71	MP0005386_behavior/neurological_phenoty	0.91331244
72	MP0004924_abnormal_behavior	0.91331244
73	MP0005595_abnormal_vascular_smooth	0.90957409
74	MP0001664_abnormal_digestion	0.90517762
75	MP0003137_abnormal_impulse_conducting	0.90177857
76	MP0002752_abnormal_somatic_nervous	0.87379634
77	MP0003786_premature_aging	0.86966265
78	MP0002064_seizures	0.86261826
79	MP0005167_abnormal_blood-brain_barrier	0.84059014
80	MP0000631_abnormal_neuroendocrine_gland	0.80225653
81	MP0002822_catalepsy	0.78360887
82	MP0002882_abnormal_neuron_morphology	0.77495182
83	MP0008872_abnormal_physiological_respon	0.77045252
84	MP0002069_abnormal_eating/drinking_beha	0.77027457
85	MP0004215_abnormal_myocardial_fiber	0.76589184
86	MP0002067_abnormal_sensory_capabilities	0.76080572
87	MP0006292_abnormal_olfactory_placode	0.75774457
88	MP0005410_abnormal_fertilization	0.75605949
89	MP0006035_abnormal_mitochondrial_morpho	0.74951624
90	MP0004085_abnormal_heartbeat	0.72655540
91	MP0001188_hyperpigmentation	0.71379801
92	MP0002332_abnormal_exercise_endurance	0.70777568
93	MP0005464_abnormal_platelet_physiology	0.70555233
94	MP0003631_nervous_system_phenotype	0.69170286
95	MP0000427_abnormal_hair_cycle	0.67081492
96	MP0002229_neurodegeneration	0.66696777
97	MP0008775_abnormal_heart_ventricle	0.64645716
98	MP0008260_abnormal_autophagy	0.63917361
99	MP0003195_calcinosis	0.62781619
100	MP0005365_abnormal_bile_salt	0.61675558

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.47725192
2	Split foot (HP:0001839)	4.33190219
3	Retinal dysplasia (HP:0007973)	4.28408808
4	Type II lissencephaly (HP:0007260)	4.10644431
5	Pancreatic fibrosis (HP:0100732)	4.08871697
6	Fibular aplasia (HP:0002990)	4.07760741
7	Abnormal biliary tract physiology (HP:0012439)	4.03283215
8	Bile duct proliferation (HP:0001408)	4.03283215
9	Lissencephaly (HP:0001339)	3.90771330
10	Nephronophthisis (HP:0000090)	3.72237391
11	True hermaphroditism (HP:0010459)	3.72197233
12	Oligodactyly (hands) (HP:0001180)	3.69804428
13	Ulnar claw (HP:0001178)	3.59050181
14	Medial flaring of the eyebrow (HP:0010747)	3.38218764
15	Abnormality of the renal medulla (HP:0100957)	3.25451760
16	3-Methylglutaconic aciduria (HP:0003535)	3.07981155
17	Nephrogenic diabetes insipidus (HP:0009806)	2.90434102
18	Gait imbalance (HP:0002141)	2.68063972
19	Cone-rod dystrophy (HP:0000548)	2.67085030
20	Polyphagia (HP:0002591)	2.66992280
21	Failure to thrive in infancy (HP:0001531)	2.66712073
22	Inability to walk (HP:0002540)	2.61597654
23	Congenital primary aphakia (HP:0007707)	2.60728936
24	Hyperventilation (HP:0002883)	2.59359558
25	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.57983984
26	Aplasia/hypoplasia of the uterus (HP:0008684)	2.57891523
27	Congenital hepatic fibrosis (HP:0002612)	2.56704477
28	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.56612971
29	Synostosis involving the elbow (HP:0003938)	2.55331054
30	Humeroradial synostosis (HP:0003041)	2.55331054
31	Oligomenorrhea (HP:0000876)	2.54918470
32	Cystic liver disease (HP:0006706)	2.53017159
33	Abnormality of the renal cortex (HP:0011035)	2.49196137
34	Narrow nasal bridge (HP:0000446)	2.48736309
35	Molar tooth sign on MRI (HP:0002419)	2.47690209
36	Abnormality of midbrain morphology (HP:0002418)	2.47690209
37	Hip dysplasia (HP:0001385)	2.44732733
38	Dyschromatopsia (HP:0007641)	2.44305677
39	Ankle clonus (HP:0011448)	2.44182882
40	Progressive inability to walk (HP:0002505)	2.44117769
41	Pachygyria (HP:0001302)	2.42782384
42	Generalized aminoaciduria (HP:0002909)	2.33375235
43	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.31721506
44	Generalized myoclonic seizures (HP:0002123)	2.28070231
45	Hypothermia (HP:0002045)	2.26687981
46	Attenuation of retinal blood vessels (HP:0007843)	2.25970505
47	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.25899732
48	Hypoplasia of the brainstem (HP:0002365)	2.25899732
49	Oligodactyly (HP:0012165)	2.24709722
50	Congenital stationary night blindness (HP:0007642)	2.22631887
51	Absent speech (HP:0001344)	2.22605785
52	Acute necrotizing encephalopathy (HP:0006965)	2.21244179
53	Genital tract atresia (HP:0001827)	2.18016960
54	Delayed CNS myelination (HP:0002188)	2.16150186
55	Vaginal atresia (HP:0000148)	2.14360626
56	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.12760447
57	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.12760447
58	Occipital encephalocele (HP:0002085)	2.12327236
59	Renal cortical cysts (HP:0000803)	2.11331261
60	Abolished electroretinogram (ERG) (HP:0000550)	2.09293834
61	Bilateral microphthalmos (HP:0007633)	2.08469858
62	Stomach cancer (HP:0012126)	2.07330712
63	Esotropia (HP:0000565)	2.06945966
64	Azoospermia (HP:0000027)	2.06938689
65	Neonatal respiratory distress (HP:0002643)	2.02354054
66	Postaxial foot polydactyly (HP:0001830)	1.98327791
67	Progressive macrocephaly (HP:0004481)	1.95549367
68	Abnormal hair whorl (HP:0010721)	1.94509906
69	Neurodegeneration (HP:0002180)	1.92974905
70	Postaxial hand polydactyly (HP:0001162)	1.90857482
71	Hemiparesis (HP:0001269)	1.87688204
72	Volvulus (HP:0002580)	1.86291335
73	Acute encephalopathy (HP:0006846)	1.84520187
74	Hypoplastic nipples (HP:0002557)	1.83680472
75	Delayed gross motor development (HP:0002194)	1.83401539
76	Focal motor seizures (HP:0011153)	1.82733353
77	Anophthalmia (HP:0000528)	1.82438739
78	Sclerocornea (HP:0000647)	1.82169403
79	Type I diabetes mellitus (HP:0100651)	1.81960989
80	Widely spaced teeth (HP:0000687)	1.80667429
81	Colon cancer (HP:0003003)	1.80313123
82	Polydipsia (HP:0001959)	1.80080852
83	Abnormal drinking behavior (HP:0030082)	1.80080852
84	Decreased central vision (HP:0007663)	1.78981606
85	Steppage gait (HP:0003376)	1.77852710
86	Cerebellar dysplasia (HP:0007033)	1.77596617
87	Thyroid-stimulating hormone excess (HP:0002925)	1.77380785
88	Disproportionate short-trunk short stature (HP:0003521)	1.77354003
89	Methylmalonic acidemia (HP:0002912)	1.76994208
90	Autoamputation (HP:0001218)	1.76064315
91	Prolonged QT interval (HP:0001657)	1.75794653
92	Carpal bone hypoplasia (HP:0001498)	1.74505288
93	Barrel-shaped chest (HP:0001552)	1.74117651
94	Hepatic necrosis (HP:0002605)	1.73072281
95	Sensorimotor neuropathy (HP:0007141)	1.72231821
96	Anterior segment dysgenesis (HP:0007700)	1.71999194
97	Anencephaly (HP:0002323)	1.71724847
98	Atonic seizures (HP:0010819)	1.68698478
99	Abnormal mitochondria in muscle tissue (HP:0008316)	1.68271271
100	Chorioretinal atrophy (HP:0000533)	1.65405572

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	7.19166563
2	TESK2	4.15060377
3	MAPK15	3.05203622
4	NUAK1	2.61168949
5	CSNK1G2	2.59228400
6	PINK1	2.51859122
7	CSNK1G3	2.50423426
8	MARK1	2.45727403
9	BCR	2.23076489
10	FRK	2.22313303
11	SRPK1	2.11029376
12	TRIM28	2.08447285
13	MAPK13	2.08255027
14	CSNK1G1	2.05139961
15	TAOK3	2.00413920
16	CSNK1A1L	1.90585412
17	ZAK	1.83218439
18	SIK3	1.78813206
19	ERBB3	1.78715803
20	TLK1	1.73978833
21	MINK1	1.67022014
22	MAP3K4	1.42254643
23	IRAK2	1.36015055
24	EIF2AK3	1.33411668
25	MAP2K7	1.30126490
26	WNK3	1.29986279
27	BCKDK	1.23447806
28	CDK3	1.20657173
29	PAK6	1.14370902
30	VRK1	1.09672616
31	PRKD3	1.06329991
32	RPS6KA4	1.01889112
33	MAPKAPK3	0.98606469
34	SIK2	0.94814336
35	ERN1	0.93336165
36	PHKG2	0.92961338
37	PHKG1	0.92961338
38	TIE1	0.90216334
39	TSSK6	0.90103647
40	CASK	0.89201916
41	PTK2B	0.83974256
42	CLK1	0.83832577
43	PLK4	0.82965855
44	GRK7	0.82907188
45	DYRK2	0.82876291
46	RPS6KA5	0.79091662
47	GRK1	0.78546365
48	PAK3	0.77989953
49	PRKCE	0.75851912
50	MAP3K6	0.72394879
51	ADRBK2	0.70527019
52	LATS1	0.68461670
53	PLK2	0.62892612
54	STK38L	0.61883847
55	PLK3	0.61535325
56	CSNK1A1	0.60646884
57	LIMK1	0.58092486
58	BRSK2	0.56893976
59	PNCK	0.56136596
60	EPHA4	0.55670861
61	DAPK2	0.51536758
62	CAMK2A	0.49321167
63	PRKG1	0.48632247
64	MAPK4	0.48165878
65	CSF1R	0.47986338
66	KIT	0.47121865
67	INSRR	0.46730565
68	CSNK1E	0.44089947
69	ADRBK1	0.44027565
70	WEE1	0.43061365
71	CHUK	0.40643541
72	TEC	0.37570490
73	PRKACA	0.37418491
74	PRKD1	0.36239502
75	ABL1	0.35857518
76	TRPM7	0.34844414
77	PRKCQ	0.34186311
78	MUSK	0.33045063
79	PIM2	0.31825658
80	FGFR2	0.31297652
81	FER	0.30973220
82	GRK5	0.30123713
83	BMPR1B	0.30112533
84	CDK9	0.29103013
85	MAP2K4	0.28458065
86	CDK14	0.26035899
87	PRKG2	0.26011359
88	EGFR	0.25096575
89	ATM	0.24787299
90	CSNK1D	0.24620461
91	IGF1R	0.23741108
92	PRKCA	0.23609001
93	MAP2K1	0.23602199
94	ATR	0.23431614
95	RAF1	0.23352235
96	PRKACB	0.23261327
97	CAMKK2	0.23213686
98	MKNK2	0.22814587
99	CSNK2A1	0.22713363
100	CDK5	0.21813504

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.30077506
2	Asthma_Homo sapiens_hsa05310	3.26548852
3	Phototransduction_Homo sapiens_hsa04744	2.55364514
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.43991069
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.16588469
6	Type I diabetes mellitus_Homo sapiens_hsa04940	2.15183639
7	Allograft rejection_Homo sapiens_hsa05330	2.09633473
8	Rheumatoid arthritis_Homo sapiens_hsa05323	2.00230192
9	Graft-versus-host disease_Homo sapiens_hsa05332	1.99451405
10	Base excision repair_Homo sapiens_hsa03410	1.97428293
11	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.95806388
12	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.94874306
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.92767553
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.91849991
15	Salivary secretion_Homo sapiens_hsa04970	1.91550941
16	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.83643840
17	Regulation of autophagy_Homo sapiens_hsa04140	1.79140095
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.76852668
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.73238264
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.68356489
21	Basal transcription factors_Homo sapiens_hsa03022	1.67884809
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.67596352
23	Nicotine addiction_Homo sapiens_hsa05033	1.66305549
24	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.65346491
25	Long-term depression_Homo sapiens_hsa04730	1.58372814
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.58031194
27	Protein export_Homo sapiens_hsa03060	1.56718378
28	Oxidative phosphorylation_Homo sapiens_hsa00190	1.47347757
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.42109630
30	Peroxisome_Homo sapiens_hsa04146	1.38760559
31	Circadian entrainment_Homo sapiens_hsa04713	1.36608547
32	Butanoate metabolism_Homo sapiens_hsa00650	1.36369621
33	Taste transduction_Homo sapiens_hsa04742	1.35801406
34	Collecting duct acid secretion_Homo sapiens_hsa04966	1.28822294
35	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.27399975
36	Selenocompound metabolism_Homo sapiens_hsa00450	1.23209560
37	GABAergic synapse_Homo sapiens_hsa04727	1.22740831
38	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.20521491
39	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.18345429
40	Parkinsons disease_Homo sapiens_hsa05012	1.05114733
41	Renin secretion_Homo sapiens_hsa04924	1.04922896
42	beta-Alanine metabolism_Homo sapiens_hsa00410	1.01355197
43	Propanoate metabolism_Homo sapiens_hsa00640	1.00686819
44	Fatty acid elongation_Homo sapiens_hsa00062	0.97749886
45	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.90796954
46	Cocaine addiction_Homo sapiens_hsa05030	0.90311319
47	Dopaminergic synapse_Homo sapiens_hsa04728	0.90047244
48	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.83654296
49	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.83580669
50	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.83453917
51	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.78527609
52	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.78410193
53	Serotonergic synapse_Homo sapiens_hsa04726	0.77939131
54	Olfactory transduction_Homo sapiens_hsa04740	0.77657187
55	ABC transporters_Homo sapiens_hsa02010	0.76501421
56	Purine metabolism_Homo sapiens_hsa00230	0.76327462
57	Glycerolipid metabolism_Homo sapiens_hsa00561	0.76147030
58	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.75448236
59	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.75059742
60	Glutamatergic synapse_Homo sapiens_hsa04724	0.74350837
61	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.73280476
62	Phagosome_Homo sapiens_hsa04145	0.71522544
63	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.70776261
64	Antigen processing and presentation_Homo sapiens_hsa04612	0.70615373
65	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.70034014
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.69040726
67	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.66729760
68	Morphine addiction_Homo sapiens_hsa05032	0.66081830
69	Viral myocarditis_Homo sapiens_hsa05416	0.65507424
70	Amphetamine addiction_Homo sapiens_hsa05031	0.65161445
71	Circadian rhythm_Homo sapiens_hsa04710	0.64838538
72	Non-homologous end-joining_Homo sapiens_hsa03450	0.63918153
73	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.63323160
74	Homologous recombination_Homo sapiens_hsa03440	0.63281545
75	Steroid biosynthesis_Homo sapiens_hsa00100	0.61226536
76	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.59017213
77	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.58637208
78	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.57212501
79	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.56724890
80	Platelet activation_Homo sapiens_hsa04611	0.51982024
81	Tyrosine metabolism_Homo sapiens_hsa00350	0.49575248
82	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.49470032
83	Nitrogen metabolism_Homo sapiens_hsa00910	0.48950495
84	Caffeine metabolism_Homo sapiens_hsa00232	0.48789558
85	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.48195162
86	Sulfur metabolism_Homo sapiens_hsa00920	0.47550836
87	RNA degradation_Homo sapiens_hsa03018	0.47002010
88	Fatty acid metabolism_Homo sapiens_hsa01212	0.45478875
89	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.43736751
90	Huntingtons disease_Homo sapiens_hsa05016	0.42683943
91	Vibrio cholerae infection_Homo sapiens_hsa05110	0.39899566
92	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.38810177
93	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38065208
94	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.37234584
95	Metabolic pathways_Homo sapiens_hsa01100	0.35418549
96	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.34314398
97	Leishmaniasis_Homo sapiens_hsa05140	0.33248906
98	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.33150651
99	Histidine metabolism_Homo sapiens_hsa00340	0.33031743
100	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.32958090

KLF7P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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