KLF8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maintenance of protein location in nucleus (GO:0051457)6.56353935
2protein localization to kinetochore (GO:0034501)6.50328335
3aminoglycoside antibiotic metabolic process (GO:0030647)6.40324653
4negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.28361199
5regulation of nuclear cell cycle DNA replication (GO:0033262)6.23181577
6histone H4-K12 acetylation (GO:0043983)6.04810133
7negative regulation of epidermis development (GO:0045683)6.04807039
8regulation of mammary gland epithelial cell proliferation (GO:0033599)5.98808777
9somite rostral/caudal axis specification (GO:0032525)5.90800480
10regulation of telomere maintenance via telomerase (GO:0032210)5.89359932
11histone H4-K5 acetylation (GO:0043981)5.75081532
12histone H4-K8 acetylation (GO:0043982)5.75081532
13negative regulation of cell cycle G2/M phase transition (GO:1902750)5.65699975
14negative regulation of telomerase activity (GO:0051974)5.49098820
15rRNA transcription (GO:0009303)5.31254361
16negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.27670857
17regulation of response to osmotic stress (GO:0047484)5.26186919
18mitotic sister chromatid segregation (GO:0000070)5.16835221
19muscle organ morphogenesis (GO:0048644)5.11686155
20regulation of MHC class I biosynthetic process (GO:0045343)5.00192160
21nuclear pore complex assembly (GO:0051292)4.91147351
22heterochromatin organization (GO:0070828)4.86592521
23negative regulation of epidermal cell differentiation (GO:0045605)4.75842375
24protein localization to chromosome, centromeric region (GO:0071459)4.73183510
25DNA replication-dependent nucleosome organization (GO:0034723)4.70244753
26DNA replication-dependent nucleosome assembly (GO:0006335)4.70244753
27regulation of cilium movement (GO:0003352)4.61234380
28positive regulation of DNA-dependent DNA replication (GO:2000105)4.50803227
29notochord development (GO:0030903)4.49477071
30DNA replication checkpoint (GO:0000076)4.46862896
31nuclear pore organization (GO:0006999)4.39776471
32rRNA methylation (GO:0031167)4.34986463
33sister chromatid segregation (GO:0000819)4.34782054
34chromatin assembly (GO:0031497)4.31704623
35phenol-containing compound catabolic process (GO:0019336)4.31046138
36cell fate commitment involved in formation of primary germ layer (GO:0060795)4.28488885
37regulation of translation in response to stress (GO:0043555)4.24294335
38histone H4-K16 acetylation (GO:0043984)4.22836627
39negative regulation of telomere maintenance (GO:0032205)4.18595458
40pre-miRNA processing (GO:0031054)4.15314419
41behavioral response to ethanol (GO:0048149)4.13409643
42rRNA modification (GO:0000154)4.05618147
43cytidine deamination (GO:0009972)4.01727414
44cytidine metabolic process (GO:0046087)4.01727414
45cytidine catabolic process (GO:0006216)4.01727414
46behavioral response to nicotine (GO:0035095)3.97000502
47regulation of hippo signaling (GO:0035330)3.96787576
48regulation of mesoderm development (GO:2000380)3.95987291
49indolalkylamine metabolic process (GO:0006586)3.93877703
50primitive streak formation (GO:0090009)3.89713646
51detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.87638472
52branching involved in mammary gland duct morphogenesis (GO:0060444)3.87204648
53response to dietary excess (GO:0002021)3.85383539
54nucleoside transmembrane transport (GO:1901642)3.84778177
55interferon-gamma production (GO:0032609)3.83818132
56tryptophan catabolic process (GO:0006569)3.83054962
57indole-containing compound catabolic process (GO:0042436)3.83054962
58indolalkylamine catabolic process (GO:0046218)3.83054962
59intestinal epithelial cell development (GO:0060576)3.82448770
60regulation of telomere maintenance (GO:0032204)3.80995779
61fucose catabolic process (GO:0019317)3.79059422
62L-fucose metabolic process (GO:0042354)3.79059422
63L-fucose catabolic process (GO:0042355)3.79059422
64regulation of apoptotic process involved in morphogenesis (GO:1902337)3.72446727
65cullin deneddylation (GO:0010388)3.70626389
66intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.69026170
67pore complex assembly (GO:0046931)3.65066945
68hormone catabolic process (GO:0042447)3.64414837
69regulation of gene silencing by RNA (GO:0060966)3.62853561
70regulation of posttranscriptional gene silencing (GO:0060147)3.62853561
71regulation of gene silencing by miRNA (GO:0060964)3.62853561
72quinone metabolic process (GO:1901661)3.56264384
73maintenance of protein localization in organelle (GO:0072595)3.54967470
74regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.54374512
75photoreceptor cell maintenance (GO:0045494)3.52313702
76platelet dense granule organization (GO:0060155)3.48549839
77formation of translation preinitiation complex (GO:0001731)3.47965029
78ribosome biogenesis (GO:0042254)3.44785967
79kynurenine metabolic process (GO:0070189)3.42251419
80mitotic chromosome condensation (GO:0007076)3.41196906
81DNA duplex unwinding (GO:0032508)3.37903821
82negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.35426158
83mitochondrion distribution (GO:0048311)3.34326949
84DNA damage response, detection of DNA damage (GO:0042769)3.34218397
85neural tube formation (GO:0001841)3.34135503
86DNA geometric change (GO:0032392)3.33958221
87RNA stabilization (GO:0043489)3.32923302
88mRNA stabilization (GO:0048255)3.32923302
89negative regulation of translation, ncRNA-mediated (GO:0040033)3.31576679
90regulation of translation, ncRNA-mediated (GO:0045974)3.31576679
91negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.31576679
92tryptophan metabolic process (GO:0006568)3.30122295
93regulation of telomerase activity (GO:0051972)3.28507266
94transcription from mitochondrial promoter (GO:0006390)3.27428093
95regulation of action potential (GO:0098900)3.26366710
96trophectodermal cell differentiation (GO:0001829)3.25688297
97regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.25405123
98reflex (GO:0060004)3.23747814
99negative regulation of cytosolic calcium ion concentration (GO:0051481)3.20638083
100protein deneddylation (GO:0000338)3.18766396
101protein polyglutamylation (GO:0018095)3.18656427
102coenzyme catabolic process (GO:0009109)3.17683939
103microtubule severing (GO:0051013)3.14565629
104regulation of microtubule-based movement (GO:0060632)3.13916640
105GDP-mannose metabolic process (GO:0019673)3.12199598
106apoptotic DNA fragmentation (GO:0006309)3.10561581
107positive regulation of protein deacetylation (GO:0090312)3.10533904
108cilium or flagellum-dependent cell motility (GO:0001539)3.10326946
109detection of light stimulus involved in sensory perception (GO:0050962)3.10192879
110detection of light stimulus involved in visual perception (GO:0050908)3.10192879
111regulation of double-strand break repair (GO:2000779)3.08204199
112endoderm formation (GO:0001706)3.07323487
113negative regulation of activin receptor signaling pathway (GO:0032926)3.05419759
114cardiovascular system development (GO:0072358)3.05130410
115thyroid hormone metabolic process (GO:0042403)3.03245411
116spindle assembly (GO:0051225)2.97122516
117retinoic acid receptor signaling pathway (GO:0048384)2.96966818
118regulation of DNA-dependent DNA replication (GO:0090329)2.96315236
119proline transport (GO:0015824)2.95961497
120G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.92880407
121negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.91420273
122intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.91382502
123pseudouridine synthesis (GO:0001522)2.90152203
124kidney morphogenesis (GO:0060993)2.89978249
125anterior/posterior axis specification (GO:0009948)2.89070044
126tachykinin receptor signaling pathway (GO:0007217)2.88835442
127protein K11-linked deubiquitination (GO:0035871)2.88503827
128bone trabecula formation (GO:0060346)2.87917499
129epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.86400448
130NLS-bearing protein import into nucleus (GO:0006607)2.85925780
131signal peptide processing (GO:0006465)2.85862046
132response to pheromone (GO:0019236)2.85012730
133indole-containing compound metabolic process (GO:0042430)2.83744532
134dopamine transport (GO:0015872)2.81382669
135positive regulation of action potential (GO:0045760)2.80188108
136establishment of protein localization to Golgi (GO:0072600)2.79939190
137positive regulation of uterine smooth muscle contraction (GO:0070474)2.76619048
138positive regulation of developmental pigmentation (GO:0048087)2.75811721
139DNA double-strand break processing (GO:0000729)2.74203209
140nonmotile primary cilium assembly (GO:0035058)2.71825429
141piRNA metabolic process (GO:0034587)2.71684263
142sequestering of extracellular ligand from receptor (GO:0035581)2.69526819
143limb bud formation (GO:0060174)2.68886171
144neuronal action potential (GO:0019228)2.66401325
145retinal cone cell development (GO:0046549)2.63608937
146regulation of collateral sprouting (GO:0048670)2.63316310
147interkinetic nuclear migration (GO:0022027)2.62409100
148cilium morphogenesis (GO:0060271)2.62023204
149negative regulation of mast cell activation (GO:0033004)2.61322602
150inner ear receptor stereocilium organization (GO:0060122)2.60427585
151cellular response to sterol (GO:0036315)2.59342810
152auditory receptor cell stereocilium organization (GO:0060088)2.59279014
153keratinocyte development (GO:0003334)2.57810470
154regulation of sarcomere organization (GO:0060297)2.56114762
155aggressive behavior (GO:0002118)2.51720175
156cornea development in camera-type eye (GO:0061303)2.48174709
157sulfation (GO:0051923)2.47538897
158DNA deamination (GO:0045006)2.46980496
159UDP-N-acetylglucosamine metabolic process (GO:0006047)2.46765667
160protein localization to cilium (GO:0061512)2.46497808
161thyroid hormone generation (GO:0006590)2.44311670
162serotonin metabolic process (GO:0042428)2.44194100
163cilium organization (GO:0044782)2.44181500
164gamma-aminobutyric acid transport (GO:0015812)2.43119864
165detection of mechanical stimulus involved in sensory perception (GO:0050974)2.42452493
166regulation of pigment cell differentiation (GO:0050932)2.40812027
167cilium assembly (GO:0042384)2.40393614
168signal transduction involved in regulation of gene expression (GO:0023019)2.40236136
169limb development (GO:0060173)2.40032168
170appendage development (GO:0048736)2.40032168
171monoubiquitinated protein deubiquitination (GO:0035520)2.40009640
172multicellular organism reproduction (GO:0032504)2.39812205
173transmission of nerve impulse (GO:0019226)2.39107732
174benzene-containing compound metabolic process (GO:0042537)2.38687368
175somite development (GO:0061053)2.37933953
176embryonic epithelial tube formation (GO:0001838)2.37577589
177axoneme assembly (GO:0035082)2.37311090
178amine catabolic process (GO:0009310)2.37264576
179cellular biogenic amine catabolic process (GO:0042402)2.37264576
180negative regulation of systemic arterial blood pressure (GO:0003085)2.36369379
181membrane depolarization during action potential (GO:0086010)2.33781300
182protein K63-linked deubiquitination (GO:0070536)2.33677297
183phosphatidylinositol acyl-chain remodeling (GO:0036149)2.32342389
184photoreceptor cell development (GO:0042461)2.31188533
185cellular ketone body metabolic process (GO:0046950)2.30889091
186primary amino compound metabolic process (GO:1901160)2.29656540
187embryonic pattern specification (GO:0009880)2.29624666
188glycosphingolipid biosynthetic process (GO:0006688)2.28433428
189regulation of glucokinase activity (GO:0033131)2.27848301
190regulation of hexokinase activity (GO:1903299)2.27848301
191smooth muscle contraction (GO:0006939)2.27290710
192doxorubicin metabolic process (GO:0044598)10.0238017
193daunorubicin metabolic process (GO:0044597)10.0238017
194polyketide metabolic process (GO:0030638)10.0238017

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.48075687
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.48075687
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.48075687
4E2F7_22180533_ChIP-Seq_HELA_Human5.42362910
5BP1_19119308_ChIP-ChIP_Hs578T_Human5.31528445
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.90731157
7NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.48320381
8GBX2_23144817_ChIP-Seq_PC3_Human3.11143379
9TP63_19390658_ChIP-ChIP_HaCaT_Human3.09747332
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.09583931
11VDR_22108803_ChIP-Seq_LS180_Human3.07870453
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.06887636
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.02910017
14SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.96101704
15ZNF274_21170338_ChIP-Seq_K562_Hela2.83318631
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.82775404
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.72696646
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.66257179
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.61671428
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.61049220
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.55957771
22* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.53346945
23TCF3_18692474_ChIP-Seq_MEFs_Mouse2.51128024
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.48190122
25TAF15_26573619_Chip-Seq_HEK293_Human2.34698508
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.34441740
27EZH2_22144423_ChIP-Seq_EOC_Human2.33216623
28FLI1_27457419_Chip-Seq_LIVER_Mouse2.30191749
29P300_19829295_ChIP-Seq_ESCs_Human2.28588088
30FOXM1_23109430_ChIP-Seq_U2OS_Human2.24339434
31NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.18259506
32IGF1R_20145208_ChIP-Seq_DFB_Human2.13772617
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.13216642
34FUS_26573619_Chip-Seq_HEK293_Human2.08444884
35PIAS1_25552417_ChIP-Seq_VCAP_Human2.07233556
36NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.03610531
37MYC_18555785_ChIP-Seq_MESCs_Mouse2.02933664
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.99786331
39EWS_26573619_Chip-Seq_HEK293_Human1.95996692
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.93153520
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.92669450
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91931601
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91792031
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.89951594
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89591972
46ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.88189296
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87433969
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.85175778
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.85082604
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.83573983
51ER_23166858_ChIP-Seq_MCF-7_Human1.82634559
52SMAD4_21799915_ChIP-Seq_A2780_Human1.81343988
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.80721787
54* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.80372653
55BCAT_22108803_ChIP-Seq_LS180_Human1.79520786
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78107422
57STAT3_23295773_ChIP-Seq_U87_Human1.76118640
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.74561754
59IRF1_19129219_ChIP-ChIP_H3396_Human1.73175330
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.72055072
61POU5F1_16518401_ChIP-PET_MESCs_Mouse1.71625444
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70438492
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69167338
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.66782604
65CBP_20019798_ChIP-Seq_JUKART_Human1.62772848
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62772848
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61952442
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61644621
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.61071675
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60086701
71AR_25329375_ChIP-Seq_VCAP_Human1.60021541
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59782349
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.59533280
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59369112
75* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.58576480
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.58571065
77AR_21572438_ChIP-Seq_LNCaP_Human1.58559796
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.57571624
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55052047
80TCF4_23295773_ChIP-Seq_U87_Human1.54592128
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.53286472
82NANOG_18692474_ChIP-Seq_MESCs_Mouse1.52887594
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51560953
84SOX2_18555785_ChIP-Seq_MESCs_Mouse1.51104467
85NANOG_18692474_ChIP-Seq_MEFs_Mouse1.49597020
86SMAD3_21741376_ChIP-Seq_HESCs_Human1.49505644
87TCF4_22108803_ChIP-Seq_LS180_Human1.46757517
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45649762
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44872852
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44671799
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44671799
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.43562942
93PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.42767031
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.41714270
95* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.40602091
96RUNX2_22187159_ChIP-Seq_PCA_Human1.37124851
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.35885693
98MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35717816
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34789388
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.34668451
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.33092707
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32395414
103SOX2_18692474_ChIP-Seq_MESCs_Mouse1.32328864
104CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30940693
105EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30667907
106OCT4_18692474_ChIP-Seq_MEFs_Mouse1.30065906
107ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29939254
108CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28584386
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28467297
110ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28236911
111CRX_20693478_ChIP-Seq_RETINA_Mouse1.27515826
112SOX2_19829295_ChIP-Seq_ESCs_Human1.27446831
113NANOG_19829295_ChIP-Seq_ESCs_Human1.27446831
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27407976
115NANOG_16518401_ChIP-PET_MESCs_Mouse1.27206951
116TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26908684
117FLI1_21867929_ChIP-Seq_TH2_Mouse1.25252892
118* E2F1_17053090_ChIP-ChIP_MCF-7_Human1.24409688
119CDX2_22108803_ChIP-Seq_LS180_Human1.24124768
120MYC_22102868_ChIP-Seq_BL_Human1.23972240
121KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23764700
122ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23725942
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23610980
124FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23080267
125SOX2_18692474_ChIP-Seq_MEFs_Mouse1.22415016
126SMAD4_21741376_ChIP-Seq_HESCs_Human1.21558020
127NOTCH1_21737748_ChIP-Seq_TLL_Human1.19911755
128ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18629420
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18567355
130TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18493320
131P53_22387025_ChIP-Seq_ESCs_Mouse1.18004908
132GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17742125
133NANOG_21062744_ChIP-ChIP_HESCs_Human1.16851250
134TP53_16413492_ChIP-PET_HCT116_Human1.16625815
135NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15330294
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15330294
137E2F1_18555785_Chip-Seq_ESCs_Mouse1.13783038
138ARNT_22903824_ChIP-Seq_MCF-7_Human1.12772754
139AHR_22903824_ChIP-Seq_MCF-7_Human1.12365472
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12316463
141OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12062628
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11214609
143FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11105412
144SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09601094
145SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09476201
146KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08446880
147KDM2B_26808549_Chip-Seq_REH_Human1.08236603
148STAT3_18555785_Chip-Seq_ESCs_Mouse1.08204179
149CMYC_18555785_Chip-Seq_ESCs_Mouse1.07554968
150TP53_22573176_ChIP-Seq_HFKS_Human1.07304799
151EST1_17652178_ChIP-ChIP_JURKAT_Human1.06450533
152SOX2_21211035_ChIP-Seq_LN229_Gbm1.05433054
153POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05056107
154TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05008721
155NANOG_16153702_ChIP-ChIP_HESCs_Human1.04970357
156BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04495380
157P300_18555785_Chip-Seq_ESCs_Mouse1.03577571
158RXR_22108803_ChIP-Seq_LS180_Human1.02861122
159CBX2_27304074_Chip-Seq_ESCs_Mouse1.01927728
160CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01097826
161CJUN_26792858_Chip-Seq_BT549_Human1.00622769
162CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00285283
163* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00014984
164KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96443410
165KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95367409
166CDX2_20551321_ChIP-Seq_CACO-2_Human0.95333356
167E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94524681
168EGR1_19374776_ChIP-ChIP_THP-1_Human0.90401426
169ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89010324
170NCOR1_26117541_ChIP-Seq_K562_Human0.88798752
171KAP1_27257070_Chip-Seq_ESCs_Mouse0.88083963
172TBX3_20139965_ChIP-Seq_ESCs_Mouse0.85179552
173MYCN_18555785_ChIP-Seq_MESCs_Mouse0.84666057
174TBX3_20139965_ChIP-Seq_MESCs_Mouse0.83848353
175FOXP3_21729870_ChIP-Seq_TREG_Human0.82237765
176NELFA_20434984_ChIP-Seq_ESCs_Mouse0.81883727
177SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79526749
178STAT3_18555785_ChIP-Seq_MESCs_Mouse0.79440025
179TP53_22127205_ChIP-Seq_IMR90_Human0.79006822
180TCF7_22412390_ChIP-Seq_EML_Mouse0.78272905
181SOX2_16153702_ChIP-ChIP_HESCs_Human0.78028961
182AR_21909140_ChIP-Seq_LNCAP_Human0.77460430
183SALL1_21062744_ChIP-ChIP_HESCs_Human0.77103523
184ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76727535
185KDM5A_27292631_Chip-Seq_BREAST_Human0.76578356
186XRN2_22483619_ChIP-Seq_HELA_Human0.74351953
187HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.73025298
188SCL_19346495_ChIP-Seq_HPC-7_Human0.71010446
189RNF2_27304074_Chip-Seq_NSC_Mouse0.70264242
190PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70003403
191ETS1_20019798_ChIP-Seq_JURKAT_Human0.69263573
192RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.68285600
193ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.68071640
194JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.65962506
195SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.65666217
196* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.64727931
197SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.64579989

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004264_abnormal_extraembryonic_tissu4.30104873
2MP0006292_abnormal_olfactory_placode4.29766727
3MP0002254_reproductive_system_inflammat4.22947140
4MP0008057_abnormal_DNA_replication4.06565539
5MP0003011_delayed_dark_adaptation4.03086648
6MP0003195_calcinosis3.82673027
7MP0003890_abnormal_embryonic-extraembry3.75919628
8MP0004858_abnormal_nervous_system3.41067787
9MP0000569_abnormal_digit_pigmentation3.32838220
10MP0004957_abnormal_blastocyst_morpholog3.28003630
11MP0005075_abnormal_melanosome_morpholog3.09145472
12MP0005394_taste/olfaction_phenotype3.03089432
13MP0005499_abnormal_olfactory_system3.03089432
14MP0003122_maternal_imprinting2.94873497
15MP0003121_genomic_imprinting2.66113500
16MP0000372_irregular_coat_pigmentation2.56377780
17MP0003136_yellow_coat_color2.54837405
18MP0002736_abnormal_nociception_after2.54389431
19MP0001968_abnormal_touch/_nociception2.45364045
20MP0002332_abnormal_exercise_endurance2.45308518
21MP0010352_gastrointestinal_tract_polyps2.30711834
22MP0008877_abnormal_DNA_methylation2.28742047
23MP0003646_muscle_fatigue2.26505825
24MP0005551_abnormal_eye_electrophysiolog2.23649044
25MP0006035_abnormal_mitochondrial_morpho2.17384988
26MP0003705_abnormal_hypodermis_morpholog2.14973880
27MP0005257_abnormal_intraocular_pressure2.12733913
28MP0000427_abnormal_hair_cycle2.11548489
29MP0002653_abnormal_ependyma_morphology2.11254704
30MP0003123_paternal_imprinting2.10192903
31MP0001984_abnormal_olfaction2.01225779
32MP0002837_dystrophic_cardiac_calcinosis1.96553633
33* MP0001672_abnormal_embryogenesis/_devel1.91723553
34* MP0005380_embryogenesis_phenotype1.91723553
35MP0008872_abnormal_physiological_respon1.87381623
36MP0003880_abnormal_central_pattern1.86072038
37MP0006054_spinal_hemorrhage1.84857796
38MP0003077_abnormal_cell_cycle1.82547634
39MP0001501_abnormal_sleep_pattern1.82050424
40MP0003938_abnormal_ear_development1.80034644
41MP0009046_muscle_twitch1.77934559
42MP0001293_anophthalmia1.73183172
43MP0000383_abnormal_hair_follicle1.73005268
44* MP0002088_abnormal_embryonic_growth/wei1.72555786
45* MP0003984_embryonic_growth_retardation1.71112961
46MP0001485_abnormal_pinna_reflex1.69519149
47MP0002102_abnormal_ear_morphology1.69424236
48MP0000350_abnormal_cell_proliferation1.69417733
49MP0005646_abnormal_pituitary_gland1.68679818
50MP0003950_abnormal_plasma_membrane1.67449822
51MP0002277_abnormal_respiratory_mucosa1.66108370
52MP0002127_abnormal_cardiovascular_syste1.65126960
53MP0009745_abnormal_behavioral_response1.63050555
54MP0002876_abnormal_thyroid_physiology1.62885569
55MP0003183_abnormal_peptide_metabolism1.60036431
56MP0003111_abnormal_nucleus_morphology1.59782973
57MP0001529_abnormal_vocalization1.59600946
58MP0001849_ear_inflammation1.58565357
59MP0000678_abnormal_parathyroid_gland1.56191542
60MP0010094_abnormal_chromosome_stability1.54570421
61MP0005253_abnormal_eye_physiology1.52760819
62MP0002086_abnormal_extraembryonic_tissu1.51805714
63MP0006072_abnormal_retinal_apoptosis1.50835755
64MP0008961_abnormal_basal_metabolism1.47694632
65MP0002085_abnormal_embryonic_tissue1.44834309
66MP0004215_abnormal_myocardial_fiber1.42371034
67MP0003787_abnormal_imprinting1.42328380
68MP0000631_abnormal_neuroendocrine_gland1.40319285
69MP0002084_abnormal_developmental_patter1.37299002
70MP0002092_abnormal_eye_morphology1.35704263
71MP0003119_abnormal_digestive_system1.33590752
72MP0005174_abnormal_tail_pigmentation1.33482514
73MP0004142_abnormal_muscle_tone1.33191798
74MP0002735_abnormal_chemical_nociception1.32709452
75MP0002396_abnormal_hematopoietic_system1.31400177
76MP0006276_abnormal_autonomic_nervous1.30038288
77MP0002272_abnormal_nervous_system1.26861935
78MP0005266_abnormal_metabolism1.25958299
79MP0003315_abnormal_perineum_morphology1.25945604
80MP0001348_abnormal_lacrimal_gland1.24119702
81MP0006082_CNS_inflammation1.23586693
82MP0002938_white_spotting1.23531054
83MP0004133_heterotaxia1.22156502
84MP0001986_abnormal_taste_sensitivity1.21381683
85MP0002932_abnormal_joint_morphology1.21051320
86MP0008789_abnormal_olfactory_epithelium1.20911802
87MP0000762_abnormal_tongue_morphology1.19886197
88MP0001486_abnormal_startle_reflex1.19642078
89MP0010030_abnormal_orbit_morphology1.19418547
90MP0001730_embryonic_growth_arrest1.19196596
91MP0003283_abnormal_digestive_organ1.17892366
92MP0005670_abnormal_white_adipose1.17773316
93MP0005386_behavior/neurological_phenoty1.16628643
94MP0004924_abnormal_behavior1.16628643
95MP0004197_abnormal_fetal_growth/weight/1.15912937
96MP0008932_abnormal_embryonic_tissue1.14831855
97MP0003693_abnormal_embryo_hatching1.14229169
98MP0000538_abnormal_urinary_bladder1.13398700
99MP0005379_endocrine/exocrine_gland_phen1.12656537
100MP0000049_abnormal_middle_ear1.12429321
101MP0004145_abnormal_muscle_electrophysio1.11818626
102MP0000490_abnormal_crypts_of1.11181636
103MP0000647_abnormal_sebaceous_gland1.10706228
104MP0002067_abnormal_sensory_capabilities1.10197662
105MP0002114_abnormal_axial_skeleton1.09741779
106MP0010386_abnormal_urinary_bladder1.09188251
107MP0002572_abnormal_emotion/affect_behav1.09153870
108MP0001697_abnormal_embryo_size1.08659351
109MP0004885_abnormal_endolymph1.06673267
110MP0002233_abnormal_nose_morphology1.06622024
111MP0000432_abnormal_head_morphology1.05937075
112MP0000313_abnormal_cell_death1.05490348
113MP0008775_abnormal_heart_ventricle1.04981834
114MP0010678_abnormal_skin_adnexa1.04942881
115MP0000230_abnormal_systemic_arterial1.01746213
116MP0002557_abnormal_social/conspecific_i1.00554370
117MP0004085_abnormal_heartbeat0.99763223
118MP0000428_abnormal_craniofacial_morphol0.98993706
119MP0008770_decreased_survivor_rate0.98481235
120MP0002234_abnormal_pharynx_morphology0.98323609
121MP0009780_abnormal_chondrocyte_physiolo0.98242708
122MP0002080_prenatal_lethality0.96312632
123MP0003935_abnormal_craniofacial_develop0.95125183
124MP0003755_abnormal_palate_morphology0.94734946
125MP0002638_abnormal_pupillary_reflex0.93081860
126MP0002928_abnormal_bile_duct0.92710079
127MP0003786_premature_aging0.91855711
128MP0004147_increased_porphyrin_level0.91693453
129MP0005645_abnormal_hypothalamus_physiol0.90973064
130MP0008007_abnormal_cellular_replicative0.90659071
131MP0002095_abnormal_skin_pigmentation0.89870172
132MP0002970_abnormal_white_adipose0.89467505
133MP0008058_abnormal_DNA_repair0.88786180
134MP0008995_early_reproductive_senescence0.87177584
135MP0005275_abnormal_skin_tensile0.86575822
136MP0005248_abnormal_Harderian_gland0.86297346
137MP0002751_abnormal_autonomic_nervous0.85507861
138MP0002138_abnormal_hepatobiliary_system0.84902329
139MP0009703_decreased_birth_body0.83951214
140MP0005084_abnormal_gallbladder_morpholo0.83714128
141MP0005391_vision/eye_phenotype0.83069913
142MP0001970_abnormal_pain_threshold0.82823472
143MP0002064_seizures0.82062144
144MP0001764_abnormal_homeostasis0.81972861
145MP0000778_abnormal_nervous_system0.81745027
146MP0005195_abnormal_posterior_eye0.81397732
147MP0004484_altered_response_of0.80194893
148MP0000015_abnormal_ear_pigmentation0.78486890
149MP0003943_abnormal_hepatobiliary_system0.78466642
150MP0002925_abnormal_cardiovascular_devel0.77899165
151MP0004742_abnormal_vestibular_system0.77245931
152MP0002752_abnormal_somatic_nervous0.76097564
153MP0003137_abnormal_impulse_conducting0.75636429
154MP0000358_abnormal_cell_content/0.74861704
155MP0001324_abnormal_eye_pigmentation0.74389189
156MP0002168_other_aberrant_phenotype0.73527384
157MP0003635_abnormal_synaptic_transmissio0.73213117
158MP0004043_abnormal_pH_regulation0.71083222
159MP0002116_abnormal_craniofacial_bone0.70609118
160MP0003861_abnormal_nervous_system0.70115026
161MP0002163_abnormal_gland_morphology0.69224853
162MP0001286_abnormal_eye_development0.67719933
163MP0004381_abnormal_hair_follicle0.67491728
164MP0005187_abnormal_penis_morphology0.67399687
165MP0002249_abnormal_larynx_morphology0.67204580
166MP0001145_abnormal_male_reproductive0.66402370
167MP0002081_perinatal_lethality0.65692072
168MP0003937_abnormal_limbs/digits/tail_de0.65486320
169MP0002109_abnormal_limb_morphology0.65331579
170MP0005384_cellular_phenotype0.65271540
171MP0005508_abnormal_skeleton_morphology0.64312725
172MP0002269_muscular_atrophy0.62657192
173MP0005623_abnormal_meninges_morphology0.62356440
174MP0003448_altered_tumor_morphology0.54763935
175MP0000750_abnormal_muscle_regeneration0.53683475
176MP0002019_abnormal_tumor_incidence0.53434643
177MP0002111_abnormal_tail_morphology0.52918568
178MP0005023_abnormal_wound_healing0.52316570
179MP0002132_abnormal_respiratory_system0.50785474
180MP0002075_abnormal_coat/hair_pigmentati0.46595399

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.04066570
2Hypochromic microcytic anemia (HP:0004840)6.62457711
3Hepatoblastoma (HP:0002884)5.52820789
4Abnormality of the lower motor neuron (HP:0002366)4.88495318
5Ependymoma (HP:0002888)4.75454676
6Multiple enchondromatosis (HP:0005701)4.72065615
7Rib fusion (HP:0000902)4.48282595
8Pancreatic cysts (HP:0001737)4.33849786
9Nephroblastoma (Wilms tumor) (HP:0002667)3.89412199
10True hermaphroditism (HP:0010459)3.87321888
11Neoplasm of striated muscle (HP:0009728)3.79903259
12Rhabdomyosarcoma (HP:0002859)3.75315827
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.75272207
14Pancreatic fibrosis (HP:0100732)3.67619392
15Embryonal renal neoplasm (HP:0011794)3.64140142
16Amyotrophic lateral sclerosis (HP:0007354)3.61454151
17Abnormality of the astrocytes (HP:0100707)3.46359956
18Astrocytoma (HP:0009592)3.46359956
19Abnormality of midbrain morphology (HP:0002418)3.44588554
20Molar tooth sign on MRI (HP:0002419)3.44588554
21Rectal fistula (HP:0100590)3.28251190
22Rectovaginal fistula (HP:0000143)3.28251190
23Chromsome breakage (HP:0040012)3.22641781
24Gaze-evoked nystagmus (HP:0000640)3.22017422
25Fused cervical vertebrae (HP:0002949)3.13539906
26Hypoplasia of the fovea (HP:0007750)3.13121119
27Aplasia/Hypoplasia of the fovea (HP:0008060)3.13121119
28Aplasia/hypoplasia of the humerus (HP:0006507)3.08678534
29Nephronophthisis (HP:0000090)3.06614945
30Short humerus (HP:0005792)3.06394517
31Abnormality of the salivary glands (HP:0010286)3.02629023
32Testicular atrophy (HP:0000029)2.99788107
33Intestinal fistula (HP:0100819)2.94559448
34Abnormality of the renal medulla (HP:0100957)2.93676653
35Medial flaring of the eyebrow (HP:0010747)2.91122909
36Congenital stationary night blindness (HP:0007642)2.91038170
37Abnormality of the renal cortex (HP:0011035)2.89708856
38Genetic anticipation (HP:0003743)2.88065338
39Supernumerary spleens (HP:0009799)2.87913877
40Horizontal nystagmus (HP:0000666)2.85521422
41Shawl scrotum (HP:0000049)2.84964233
42Abnormal lung lobation (HP:0002101)2.81347684
43Chronic hepatic failure (HP:0100626)2.80824997
44Impulsivity (HP:0100710)2.80085601
45Bifid tongue (HP:0010297)2.77483938
46Vaginal fistula (HP:0004320)2.75923841
47Hypochromic anemia (HP:0001931)2.75250325
48Attenuation of retinal blood vessels (HP:0007843)2.73411884
49Type II lissencephaly (HP:0007260)2.69539406
50Partial duplication of thumb phalanx (HP:0009944)2.69102412
51Cystic liver disease (HP:0006706)2.67051315
52Ragged-red muscle fibers (HP:0003200)2.66786532
53Trismus (HP:0000211)2.65714231
54Inability to walk (HP:0002540)2.61812120
55Hypoplastic labia majora (HP:0000059)2.60398095
56Abolished electroretinogram (ERG) (HP:0000550)2.59222939
57Hypothermia (HP:0002045)2.59017371
58Glioma (HP:0009733)2.57772063
59Absent speech (HP:0001344)2.57035756
60Hyperinsulinemic hypoglycemia (HP:0000825)2.56507875
61Aplasia/Hypoplasia of the tibia (HP:0005772)2.55689609
62Meckel diverticulum (HP:0002245)2.53983331
63Anomalous pulmonary venous return (HP:0010772)2.51240974
64Genital tract atresia (HP:0001827)2.50904341
65Preauricular skin tag (HP:0000384)2.48674611
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.47179438
67Abnormality of alanine metabolism (HP:0010916)2.47179438
68Hyperalaninemia (HP:0003348)2.47179438
69Gait imbalance (HP:0002141)2.47159231
70Periauricular skin pits (HP:0100277)2.46411476
71Preauricular pit (HP:0004467)2.46411476
72Vaginal atresia (HP:0000148)2.45501978
73Furrowed tongue (HP:0000221)2.45126171
74Tetraplegia (HP:0002445)2.44340146
75Broad-based gait (HP:0002136)2.44331877
76Abnormality of the ileum (HP:0001549)2.43654556
77Fair hair (HP:0002286)2.42422270
78Large earlobe (HP:0009748)2.42395441
79Stomach cancer (HP:0012126)2.40315253
80Progressive cerebellar ataxia (HP:0002073)2.39597429
81Abnormality of chromosome segregation (HP:0002916)2.38896629
82Aplasia/Hypoplasia of the uvula (HP:0010293)2.38708706
83Sensory axonal neuropathy (HP:0003390)2.37341514
84Tubular atrophy (HP:0000092)2.36891176
85Congenital primary aphakia (HP:0007707)2.36367116
86Abnormal cartilage morphology (HP:0002763)2.36168253
87Aplasia/Hypoplasia of the tongue (HP:0010295)2.35769613
88Abnormality of the labia majora (HP:0012881)2.34301963
89Atrophy/Degeneration involving motor neurons (HP:0007373)2.33094061
90Reduced antithrombin III activity (HP:0001976)2.33069648
91Partial duplication of the phalanx of hand (HP:0009999)2.32521095
92Progressive inability to walk (HP:0002505)2.32133749
93Anencephaly (HP:0002323)2.30572683
94Generalized hypotonia (HP:0001290)2.30271787
95Febrile seizures (HP:0002373)2.29164333
96Large for gestational age (HP:0001520)2.28382613
97Intestinal atresia (HP:0011100)2.27691358
98Abnormality of the fovea (HP:0000493)2.26638079
99Tongue fasciculations (HP:0001308)2.26329399
100Bile duct proliferation (HP:0001408)2.25146265
101Abnormal biliary tract physiology (HP:0012439)2.25146265
102Medulloblastoma (HP:0002885)2.24191938
103Aplasia/Hypoplasia of the sternum (HP:0006714)2.22554263
104Cerebellar dysplasia (HP:0007033)2.22316733
105Upper motor neuron abnormality (HP:0002127)2.21667510
106Clumsiness (HP:0002312)2.21176976
107Oligodactyly (hands) (HP:0001180)2.20694554
108Abnormality of the musculature of the hand (HP:0001421)2.20649570
109Skin tags (HP:0010609)2.20397003
110Labial hypoplasia (HP:0000066)2.20252623
111Nasolacrimal duct obstruction (HP:0000579)2.20168621
112Concave nail (HP:0001598)2.20042261
113Protruding tongue (HP:0010808)2.19787872
114Pendular nystagmus (HP:0012043)2.19542797
115Glossoptosis (HP:0000162)2.19327668
116Decreased circulating renin level (HP:0003351)2.19253668
117Widely spaced teeth (HP:0000687)2.18984993
118Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.18869831
119Hyperventilation (HP:0002883)2.18407716
120Abnormality of the phalanges of the hallux (HP:0010057)2.16154471
121Increased corneal curvature (HP:0100692)2.15776736
122Keratoconus (HP:0000563)2.15776736
123Malignant neoplasm of the central nervous system (HP:0100836)2.14848019
124Nephrogenic diabetes insipidus (HP:0009806)2.14232311
125Progressive muscle weakness (HP:0003323)2.12487940
126Abnormality of the pulmonary veins (HP:0011718)2.11769356
127Sclerocornea (HP:0000647)2.11209564
128Volvulus (HP:0002580)2.10387028
129Short 5th finger (HP:0009237)2.07930785
130Difficulty running (HP:0009046)2.07344955
131Thyroid-stimulating hormone excess (HP:0002925)2.06691800
132Broad alveolar ridges (HP:0000187)2.05648968
133Aplasia/Hypoplasia of the macula (HP:0008059)2.05026594
134Preaxial foot polydactyly (HP:0001841)2.04141089
135Abnormal pancreas size (HP:0012094)2.03955544
136Muscle fibrillation (HP:0010546)2.03312171
137Congenital hepatic fibrosis (HP:0002612)2.02946257
138Neoplasm of the oral cavity (HP:0100649)2.02613604
139Abnormal drinking behavior (HP:0030082)2.01502570
140Polydipsia (HP:0001959)2.01502570
141Embryonal neoplasm (HP:0002898)2.01115299
142Hand muscle atrophy (HP:0009130)2.00728189
143Abnormality of the pubic bones (HP:0003172)1.99092917
144Premature ovarian failure (HP:0008209)1.98993750
145Supernumerary nipples (HP:0002558)1.98588880
146Abnormality of macular pigmentation (HP:0008002)1.98059941
147Skin pits (HP:0100276)1.98058068
148Neoplasm of the heart (HP:0100544)1.96429158
149Microvesicular hepatic steatosis (HP:0001414)1.95880961
150Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.95583646
151Hypopigmentation of the fundus (HP:0007894)1.95464859
152Optic nerve hypoplasia (HP:0000609)1.94293186
153Postaxial foot polydactyly (HP:0001830)1.93866542
154Small intestinal stenosis (HP:0012848)1.92780783
155Duodenal stenosis (HP:0100867)1.92780783
156Abnormality of the ischium (HP:0003174)1.92282606
157Increased connective tissue (HP:0009025)1.92137872
158Dialeptic seizures (HP:0011146)1.91763474
159Small hand (HP:0200055)1.91240106
160Resting tremor (HP:0002322)1.90119615
161Hypoplastic ischia (HP:0003175)1.89870224
162Polyuria (HP:0000103)1.88830516
163Amblyopia (HP:0000646)1.88189388
164Abnormality of the distal phalanx of the thumb (HP:0009617)1.88043217
165Abnormality of small intestinal villus morphology (HP:0011472)1.87557655
166Villous atrophy (HP:0011473)1.87557655
167Renal duplication (HP:0000075)1.87501318
168Amelogenesis imperfecta (HP:0000705)1.87343126
169Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87141426
170Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.85925027
171Cheilitis (HP:0100825)1.85368707
172Short hallux (HP:0010109)1.84628625
173Hypoplastic female external genitalia (HP:0012815)1.84617671
174Vertebral fusion (HP:0002948)1.84477223
175Focal seizures (HP:0007359)1.83035436
176Aplasia/Hypoplasia of the hallux (HP:0008362)1.82132299
177Duplicated collecting system (HP:0000081)1.81920484
178Male pseudohermaphroditism (HP:0000037)1.80944026
179Abnormality of the renal collecting system (HP:0004742)1.80553394
180Generalized hypopigmentation of hair (HP:0011358)1.80250106
181Preaxial hand polydactyly (HP:0001177)1.79380062
182Atonic seizures (HP:0010819)1.79245807
183Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79151450
184Lissencephaly (HP:0001339)1.79016938
185Poor coordination (HP:0002370)1.77571520
186Renal cortical cysts (HP:0000803)1.77179618
187Cupped ear (HP:0000378)1.76092219
188Absent/shortened dynein arms (HP:0200106)1.75402972
189Dynein arm defect of respiratory motile cilia (HP:0012255)1.75402972
190Anophthalmia (HP:0000528)1.74870391
191Short foot (HP:0001773)1.74751403
192Abnormal rod and cone electroretinograms (HP:0008323)1.72344086
193Postaxial hand polydactyly (HP:0001162)1.71139527
194Dandy-Walker malformation (HP:0001305)1.69606504
195Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.68828328

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK129.03863038
2FRK6.62121786
3GRK55.01249064
4ERN14.18967413
5GRK63.77633982
6BMPR1B3.11911782
7GRK12.88477109
8CSF1R2.85099653
9TYRO32.80797092
10TTK2.74138176
11ADRBK22.70734109
12MATK2.59346023
13TRIM282.52742273
14TNIK2.44874087
15GRK72.43690002
16MAPK132.43499556
17WNK32.32784024
18MAPK72.26119831
19TGFBR22.23845938
20CASK2.22392155
21MAP4K22.12822104
22NUAK12.01484074
23PINK11.99967212
24STK101.98553888
25WNK11.95552079
26MAPKAPK31.92379444
27MOS1.89636931
28MAP3K41.81358168
29CDK71.81190969
30MKNK21.71851428
31MST41.69644885
32STK38L1.65672333
33BCR1.65669427
34AKT31.63999076
35ZAK1.61855940
36INSRR1.58808252
37TAOK31.57427114
38NTRK11.57017661
39TRPM71.52220083
40CHEK21.46690260
41EPHA21.44790593
42CAMK41.36991516
43LATS11.35279591
44PLK11.34564499
45OXSR11.34483697
46TGFBR11.33732866
47BRSK21.28907145
48PRKG21.25329874
49PAK41.23237095
50ERBB31.21901283
51MARK21.21130203
52DAPK21.17928719
53EIF2AK31.13119820
54SIK31.12819790
55MAP2K41.09837600
56HIPK21.05257907
57CDC71.02256064
58PRKCE1.01851874
59FGFR31.01711799
60STK31.00311545
61LATS20.98443835
62CHEK10.97892265
63MAPKAPK50.96452585
64WEE10.96093913
65ALK0.95231217
66ADRBK10.94848898
67NLK0.92428861
68STK390.91521287
69MKNK10.91456650
70PIK3CG0.90399152
71FER0.90247695
72NTRK30.87970897
73MAP3K90.84729047
74NEK20.83944487
75PTK2B0.83457965
76TXK0.82479030
77TEC0.81201144
78PLK40.80508066
79MAP3K100.78897124
80CSK0.78777161
81PNCK0.75926621
82MUSK0.75684921
83AKT20.74478359
84PRKAA20.73399700
85FGFR20.72008878
86TNK20.71991262
87EIF2AK20.70652378
88PBK0.70423104
89CAMKK20.69535457
90PLK20.67272978
91EEF2K0.65331807
92DYRK30.64750088
93MAP2K70.64618107
94BUB10.64217272
95IRAK10.63961964
96CDK20.63883029
97PIK3CA0.62573950
98PRKCG0.61711138
99OBSCN0.61256552
100MAP2K60.59937729
101MTOR0.59913335
102PRKCI0.58564657
103RPS6KB20.55846548
104DYRK20.54511989
105ATM0.52320443
106MAPK120.51040739
107SGK20.50591941
108PKN10.49865476
109NEK10.48942522
110STK240.48388419
111AURKA0.48196270
112CSNK1G20.46437259
113CSNK1G10.44848228
114CAMK1G0.44443023
115VRK10.43751111
116CAMK2A0.43558194
117EPHA40.43518615
118CDK40.43336857
119WNK40.42095008
120CSNK1E0.41471559
121CDK10.39138437
122AURKB0.39051884
123TIE10.38621534
124MAP3K70.38317466
125MAPK100.37632959
126PHKG10.36873765
127PHKG20.36873765
128CAMK10.36580211
129PAK10.36458306
130MELK0.35932254
131PRKCQ0.35806452
132FLT30.35326248
133PRKG10.33875185
134BRD40.32898323
135TLK10.32807635
136KIT0.32421585
137ICK0.32347657
138CDK30.32245617
139PRKACA0.32183725
140YES10.32057134
141CSNK1A10.31144096
142GSK3B0.30843637
143DYRK1A0.30587638
144MARK10.30401444
145IKBKB0.29964744
146IGF1R0.28903080
147MAP2K10.28455690
148DMPK0.28214698
149ABL10.28109633
150MAPK140.27974652
151MAPK10.27038184
152ERBB20.26249449
153PRKCD0.25757365
154CDK150.23588212
155PRPF4B0.22813652
156CDK11A0.22717133
157PTK20.22546618
158DDR20.22262658
159ATR0.21922437
160NTRK20.20864405
161CDK180.20523844
162SIK20.20505734
163PRKAA10.20488690
164PDGFRA0.20069994
165INSR0.19710797
166RIPK10.19562579
167SRPK10.18761936
168MAPK40.17440680
169STK380.16970956
170PRKACB0.16837834
171CHUK0.16486536
172PRKACG0.16434809
173PAK30.15794641
174ITK0.15171047
175BMX0.14666134
176CDK140.14259456
177CAMK1D0.13705516
178CSNK1D0.13153361
179GSK3A0.12248878
180ACVR1B0.11308500
181MAPK80.11149183
182AKT10.11126485

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.87954356
2Vitamin B6 metabolism_Homo sapiens_hsa007505.80559125
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.89674662
4Fructose and mannose metabolism_Homo sapiens_hsa000513.46990774
5Phototransduction_Homo sapiens_hsa047442.81704167
6RNA transport_Homo sapiens_hsa030132.55561103
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.53011419
8Butanoate metabolism_Homo sapiens_hsa006502.48826629
9Nicotine addiction_Homo sapiens_hsa050332.30467782
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.26860951
11Galactose metabolism_Homo sapiens_hsa000522.18608415
12Arachidonic acid metabolism_Homo sapiens_hsa005902.17495782
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.14256502
14Nitrogen metabolism_Homo sapiens_hsa009102.13087475
15ABC transporters_Homo sapiens_hsa020102.01674987
16Tryptophan metabolism_Homo sapiens_hsa003802.01653357
17mRNA surveillance pathway_Homo sapiens_hsa030151.99757504
18Fanconi anemia pathway_Homo sapiens_hsa034601.96278758
19Mismatch repair_Homo sapiens_hsa034301.92189367
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82799806
21Propanoate metabolism_Homo sapiens_hsa006401.82713820
22DNA replication_Homo sapiens_hsa030301.80137916
23Cell cycle_Homo sapiens_hsa041101.73718018
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72187559
25mTOR signaling pathway_Homo sapiens_hsa041501.69743435
26Linoleic acid metabolism_Homo sapiens_hsa005911.69179434
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68728484
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.66932769
29Thyroid cancer_Homo sapiens_hsa052161.66757537
30Selenocompound metabolism_Homo sapiens_hsa004501.61758268
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57093895
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.55285016
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54743672
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.52969209
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.48917838
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.47907403
37Olfactory transduction_Homo sapiens_hsa047401.47204617
38Dorso-ventral axis formation_Homo sapiens_hsa043201.41899732
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.41322634
40Homologous recombination_Homo sapiens_hsa034401.37548141
41Spliceosome_Homo sapiens_hsa030401.36522083
42Morphine addiction_Homo sapiens_hsa050321.36439230
43Ribosome_Homo sapiens_hsa030101.34948584
44One carbon pool by folate_Homo sapiens_hsa006701.33514052
45RNA degradation_Homo sapiens_hsa030181.32736157
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29752053
47Circadian entrainment_Homo sapiens_hsa047131.29668891
48Glutamatergic synapse_Homo sapiens_hsa047241.26811913
49Circadian rhythm_Homo sapiens_hsa047101.25870977
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.25217294
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21711815
52Protein export_Homo sapiens_hsa030601.20125026
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17318579
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16888177
55Calcium signaling pathway_Homo sapiens_hsa040201.14470523
56Base excision repair_Homo sapiens_hsa034101.13606489
57Retinol metabolism_Homo sapiens_hsa008301.12808504
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12684311
59Basal transcription factors_Homo sapiens_hsa030221.12464834
60Pentose and glucuronate interconversions_Homo sapiens_hsa000401.10204564
61Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09229488
62Maturity onset diabetes of the young_Homo sapiens_hsa049501.08282040
63Glycerolipid metabolism_Homo sapiens_hsa005611.07192579
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06381539
65RNA polymerase_Homo sapiens_hsa030201.05063882
66p53 signaling pathway_Homo sapiens_hsa041151.03623751
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.99916054
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99288533
69Histidine metabolism_Homo sapiens_hsa003400.97209765
70GABAergic synapse_Homo sapiens_hsa047270.95368138
71Salivary secretion_Homo sapiens_hsa049700.94461553
72Peroxisome_Homo sapiens_hsa041460.94152351
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92665922
74MicroRNAs in cancer_Homo sapiens_hsa052060.91654001
75beta-Alanine metabolism_Homo sapiens_hsa004100.89096255
76Insulin secretion_Homo sapiens_hsa049110.88923025
77Inositol phosphate metabolism_Homo sapiens_hsa005620.88552306
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.88138726
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.86751959
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85813248
81cAMP signaling pathway_Homo sapiens_hsa040240.83150179
82Nucleotide excision repair_Homo sapiens_hsa034200.80855870
83Hedgehog signaling pathway_Homo sapiens_hsa043400.80446757
84Basal cell carcinoma_Homo sapiens_hsa052170.79951585
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79652799
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78245887
87Pathways in cancer_Homo sapiens_hsa052000.77691389
88Sphingolipid metabolism_Homo sapiens_hsa006000.76197666
89Steroid biosynthesis_Homo sapiens_hsa001000.74565848
90Dopaminergic synapse_Homo sapiens_hsa047280.72430191
91Choline metabolism in cancer_Homo sapiens_hsa052310.71873627
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.70986522
93Regulation of autophagy_Homo sapiens_hsa041400.70948299
94Sulfur metabolism_Homo sapiens_hsa009200.70590721
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70451726
96Acute myeloid leukemia_Homo sapiens_hsa052210.69292133
97Herpes simplex infection_Homo sapiens_hsa051680.68673750
98Ovarian steroidogenesis_Homo sapiens_hsa049130.67902943
99Oxytocin signaling pathway_Homo sapiens_hsa049210.67628760
100Hippo signaling pathway_Homo sapiens_hsa043900.67615015
101Ether lipid metabolism_Homo sapiens_hsa005650.66339128
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.65221004
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63815371
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63779907
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63130700
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60871690
107Pentose phosphate pathway_Homo sapiens_hsa000300.60553056
108Non-homologous end-joining_Homo sapiens_hsa034500.59978161
109Caffeine metabolism_Homo sapiens_hsa002320.59649969
110Renin secretion_Homo sapiens_hsa049240.58474841
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57824048
112Rap1 signaling pathway_Homo sapiens_hsa040150.57760632
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57535916
114Amphetamine addiction_Homo sapiens_hsa050310.57106459
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56583569
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56294433
117Vitamin digestion and absorption_Homo sapiens_hsa049770.56263013
118Wnt signaling pathway_Homo sapiens_hsa043100.53985604
119Asthma_Homo sapiens_hsa053100.53894337
120Collecting duct acid secretion_Homo sapiens_hsa049660.53810841
121Cholinergic synapse_Homo sapiens_hsa047250.52723441
122Pyrimidine metabolism_Homo sapiens_hsa002400.52242465
123Oocyte meiosis_Homo sapiens_hsa041140.51607405
124Notch signaling pathway_Homo sapiens_hsa043300.49307113
125Non-small cell lung cancer_Homo sapiens_hsa052230.48979787
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48291226
127Folate biosynthesis_Homo sapiens_hsa007900.48171666
128African trypanosomiasis_Homo sapiens_hsa051430.47577988
129Other glycan degradation_Homo sapiens_hsa005110.46747430
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.46266877
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46244060
132Lysine degradation_Homo sapiens_hsa003100.45459651
133Chemical carcinogenesis_Homo sapiens_hsa052040.45161852
134Colorectal cancer_Homo sapiens_hsa052100.44160540
135Pancreatic secretion_Homo sapiens_hsa049720.43832813
136Fatty acid degradation_Homo sapiens_hsa000710.43368745
137Type II diabetes mellitus_Homo sapiens_hsa049300.43197104
138Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42983208
139Apoptosis_Homo sapiens_hsa042100.42807939
140Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42771908
141Graft-versus-host disease_Homo sapiens_hsa053320.42164174
142Cocaine addiction_Homo sapiens_hsa050300.42008046
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41302782
144Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40687714
145Gastric acid secretion_Homo sapiens_hsa049710.40597652
146Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39745649
147AMPK signaling pathway_Homo sapiens_hsa041520.39362134
148Taste transduction_Homo sapiens_hsa047420.38459488
149Fat digestion and absorption_Homo sapiens_hsa049750.37727942
150Viral carcinogenesis_Homo sapiens_hsa052030.37375366
151Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36577093
152HTLV-I infection_Homo sapiens_hsa051660.35666848
153Serotonergic synapse_Homo sapiens_hsa047260.34481591
154Bladder cancer_Homo sapiens_hsa052190.33849620
155Proteoglycans in cancer_Homo sapiens_hsa052050.32165271
156Tight junction_Homo sapiens_hsa045300.31662056
157VEGF signaling pathway_Homo sapiens_hsa043700.30755027
158Long-term depression_Homo sapiens_hsa047300.29476076
159NF-kappa B signaling pathway_Homo sapiens_hsa040640.29397003
160Sphingolipid signaling pathway_Homo sapiens_hsa040710.28120465
161Ras signaling pathway_Homo sapiens_hsa040140.26665796
162Renin-angiotensin system_Homo sapiens_hsa046140.24818657
163PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24355976
164Pancreatic cancer_Homo sapiens_hsa052120.23444540
165Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23110296
166Small cell lung cancer_Homo sapiens_hsa052220.22794564
167Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.22632817
168Adherens junction_Homo sapiens_hsa045200.21497807
169Neurotrophin signaling pathway_Homo sapiens_hsa047220.18230604
170TGF-beta signaling pathway_Homo sapiens_hsa043500.17678209

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