KLF9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal action potential propagation (GO:0019227)3.86599432
2central nervous system myelination (GO:0022010)3.82278750
3axon ensheathment in central nervous system (GO:0032291)3.82278750
4locomotory exploration behavior (GO:0035641)3.62351566
5vocalization behavior (GO:0071625)3.55158159
6L-amino acid import (GO:0043092)3.50030695
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.48585871
8neuron cell-cell adhesion (GO:0007158)3.39140220
9ionotropic glutamate receptor signaling pathway (GO:0035235)3.35231251
10synaptic vesicle exocytosis (GO:0016079)3.26295499
11sarcoplasmic reticulum calcium ion transport (GO:0070296)3.26195926
12glutamate receptor signaling pathway (GO:0007215)3.25646845
13C4-dicarboxylate transport (GO:0015740)3.24693356
14glutamate secretion (GO:0014047)3.23159828
15negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.22561108
16regulation of short-term neuronal synaptic plasticity (GO:0048172)3.19970018
17gamma-aminobutyric acid transport (GO:0015812)3.16032120
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.11753968
19presynaptic membrane assembly (GO:0097105)3.11143718
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.10590603
21presynaptic membrane organization (GO:0097090)3.06435168
22gamma-aminobutyric acid signaling pathway (GO:0007214)3.03214502
23transmission of nerve impulse (GO:0019226)3.02405823
24actin-myosin filament sliding (GO:0033275)3.01297384
25muscle filament sliding (GO:0030049)3.01297384
26regulation of p38MAPK cascade (GO:1900744)2.98911986
27peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.95692635
28regulation of long-term neuronal synaptic plasticity (GO:0048169)2.94809410
29negative regulation of synaptic transmission, GABAergic (GO:0032229)2.93984874
30neuron-neuron synaptic transmission (GO:0007270)2.93633596
31protein localization to synapse (GO:0035418)2.88456270
32neuron remodeling (GO:0016322)2.85470102
33amino acid import (GO:0043090)2.84570938
34regulation of neuronal synaptic plasticity (GO:0048168)2.84143526
35regulation of glutamate receptor signaling pathway (GO:1900449)2.83259594
36synaptic vesicle maturation (GO:0016188)2.82911210
37behavioral response to cocaine (GO:0048148)2.82080267
38synaptic transmission, glutamatergic (GO:0035249)2.80885157
39long term synaptic depression (GO:0060292)2.78631896
40regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.78152949
41exploration behavior (GO:0035640)2.76893381
42regulation of synaptic vesicle exocytosis (GO:2000300)2.75989663
43cerebellar granule cell differentiation (GO:0021707)2.74841413
44regulation of dendritic spine morphogenesis (GO:0061001)2.74814321
45neuron recognition (GO:0008038)2.74603798
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.73838060
47long-term synaptic potentiation (GO:0060291)2.73677204
48regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.73393351
49regulation of excitatory postsynaptic membrane potential (GO:0060079)2.73248678
50regulation of relaxation of muscle (GO:1901077)2.71832572
51creatine metabolic process (GO:0006600)2.71080203
52cellular potassium ion homeostasis (GO:0030007)2.69803445
53negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.69109145
54regulation of voltage-gated calcium channel activity (GO:1901385)2.67912973
55positive regulation of p38MAPK cascade (GO:1900745)2.67907390
56detection of calcium ion (GO:0005513)2.67405621
57response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.67194948
58neurotransmitter-gated ion channel clustering (GO:0072578)2.67036322
59regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.66678868
60negative regulation of erythrocyte differentiation (GO:0045647)2.66321059
61negative regulation of neurotransmitter transport (GO:0051589)2.65478299
62long-term memory (GO:0007616)2.64042708
63myofibril assembly (GO:0030239)2.63752981
64G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.62769064
65regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.61002436
66sodium ion export (GO:0071436)2.60916331
67regulation of postsynaptic membrane potential (GO:0060078)2.56435299
68cardiac muscle contraction (GO:0060048)2.55603186
69neurotransmitter secretion (GO:0007269)2.55590768
70positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.55328525
71actin-mediated cell contraction (GO:0070252)2.54212832
72striated muscle hypertrophy (GO:0014897)2.53560270
73regulation of synaptic plasticity (GO:0048167)2.53335821
74regulation of T-helper 2 cell differentiation (GO:0045628)2.53098186
75regulation of synaptic vesicle transport (GO:1902803)2.52655270
76positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.52312753
77cardiac muscle hypertrophy (GO:0003300)2.50547816
78positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.50341466
79regulation of dendritic spine development (GO:0060998)2.49844609
80complement activation, alternative pathway (GO:0006957)2.48674969
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.47673103
82myelination (GO:0042552)2.47586690
83synaptic vesicle docking involved in exocytosis (GO:0016081)2.47348647
84regulation of skeletal muscle contraction (GO:0014819)2.46685389
85dendritic spine morphogenesis (GO:0060997)2.46547885
86response to inactivity (GO:0014854)2.45079915
87axon ensheathment (GO:0008366)2.44338695
88ensheathment of neurons (GO:0007272)2.44338695
89response to epinephrine (GO:0071871)2.43494467
90negative regulation of protein localization to cell surface (GO:2000009)2.43380916
91erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.42464973
92L-phenylalanine catabolic process (GO:0006559)2.42464973
93regulation of glutamate secretion (GO:0014048)2.41866841
94skeletal muscle adaptation (GO:0043501)2.41443394
95female mating behavior (GO:0060180)2.41374038
96neurotransmitter transport (GO:0006836)2.41320738
97positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.41282862
98axonal fasciculation (GO:0007413)2.41234822
99muscle hypertrophy (GO:0014896)2.40249274
100regulation of synaptic transmission, glutamatergic (GO:0051966)2.39830448
101fatty acid elongation (GO:0030497)2.39644649
102positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.39523868
103regulation of actin filament-based movement (GO:1903115)2.38828756
104striated muscle contraction (GO:0006941)2.38269955
105protein targeting to Golgi (GO:0000042)2.37337498
106response to histamine (GO:0034776)2.36241029
107neuronal ion channel clustering (GO:0045161)2.36226554
108positive regulation of extracellular matrix organization (GO:1903055)2.35965644
109neuromuscular process controlling balance (GO:0050885)2.35921555
110cardiac myofibril assembly (GO:0055003)2.35634676
111regulation of vesicle fusion (GO:0031338)2.35239753
112neurotransmitter uptake (GO:0001504)2.34933046
113potassium ion import (GO:0010107)2.34820561
114mating behavior (GO:0007617)2.34707832
115negative regulation of synaptic transmission (GO:0050805)2.34396927
116regulation of cell communication by electrical coupling (GO:0010649)2.33897837
117cGMP-mediated signaling (GO:0019934)2.30977591
118regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.30839222
119response to methylmercury (GO:0051597)2.30287453
120regulation of female receptivity (GO:0045924)2.30088870
121postsynaptic membrane organization (GO:0001941)2.29998005
122skeletal muscle contraction (GO:0003009)2.29355470
123positive regulation of membrane potential (GO:0045838)2.28736333
124regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.28038458
125regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.27598846
126glutamate metabolic process (GO:0006536)2.26659481
127short-chain fatty acid metabolic process (GO:0046459)2.25892008
128relaxation of cardiac muscle (GO:0055119)2.25804566
129cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.24867526
130long-chain fatty acid biosynthetic process (GO:0042759)2.24678205
131regulation of complement activation (GO:0030449)2.23611353
132regulation of neurotransmitter levels (GO:0001505)2.23569256
133positive regulation of dendritic spine development (GO:0060999)2.22653238
134cellular response to epinephrine stimulus (GO:0071872)2.22653001
135positive regulation of fibroblast migration (GO:0010763)2.22415964
136regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.21613742
137calcium-mediated signaling using intracellular calcium source (GO:0035584)2.21055132
138regulation of membrane protein ectodomain proteolysis (GO:0051043)2.20618936
139acidic amino acid transport (GO:0015800)2.20610635
140relaxation of muscle (GO:0090075)2.20062006
141neuromuscular process controlling posture (GO:0050884)2.19775068
142striated muscle adaptation (GO:0014888)2.19600643
143erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.19521414
144L-phenylalanine metabolic process (GO:0006558)2.19521414
145regulation of protein activation cascade (GO:2000257)2.18395512
146cardiac muscle hypertrophy in response to stress (GO:0014898)2.17519637
147muscle hypertrophy in response to stress (GO:0003299)2.17519637
148cardiac muscle adaptation (GO:0014887)2.17519637
149cellular sodium ion homeostasis (GO:0006883)2.17518778
150positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.15790361
151actin filament-based movement (GO:0030048)2.15719326
152growth hormone receptor signaling pathway (GO:0060396)2.15530236
153negative regulation of complement activation (GO:0045916)2.15459936
154regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.13226118
155barbed-end actin filament capping (GO:0051016)2.11870326
156extracellular matrix assembly (GO:0085029)2.11204483
157response to mercury ion (GO:0046689)2.11091535
158cytoskeletal anchoring at plasma membrane (GO:0007016)2.11000559
159regulation of ARF protein signal transduction (GO:0032012)2.10567427
160positive regulation of Rap GTPase activity (GO:0032854)2.08622039
161germinal center formation (GO:0002467)2.07302630
162muscle contraction (GO:0006936)2.06461954
163negative regulation of protein activation cascade (GO:2000258)2.05517396
164import into cell (GO:0098657)2.03023832
165regulation of macrophage cytokine production (GO:0010935)2.02908677
166response to laminar fluid shear stress (GO:0034616)2.01830289
167regulation of macrophage chemotaxis (GO:0010758)2.01582401
168negative regulation of fatty acid transport (GO:2000192)2.00825232
169response to muscle activity (GO:0014850)2.00385792
170regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00431.99490716
171cell volume homeostasis (GO:0006884)1.99081301
172cell communication by electrical coupling (GO:0010644)1.98449916
173regulation of calcium ion transmembrane transport (GO:1903169)1.97780432
174regulation of calcium ion transmembrane transporter activity (GO:1901019)1.97780432
175muscle system process (GO:0003012)1.97585529
176response to fluid shear stress (GO:0034405)1.97020131
177ovulation from ovarian follicle (GO:0001542)1.96945137
178sarcomere organization (GO:0045214)1.96276439
179regulation of energy homeostasis (GO:2000505)1.94004942
180regulation of striated muscle contraction (GO:0006942)1.92424266
181carnitine shuttle (GO:0006853)1.91608898
182regulation of the force of heart contraction (GO:0002026)1.91202478
183endocrine hormone secretion (GO:0060986)1.90968121
184activation of protein kinase A activity (GO:0034199)1.88839733
185regulation of muscle adaptation (GO:0043502)1.88501501
186cellular response to growth hormone stimulus (GO:0071378)1.88305305
187platelet-derived growth factor receptor signaling pathway (GO:0048008)1.87793008
188regulation of cardiac muscle hypertrophy (GO:0010611)1.87790215
189positive regulation of macrophage cytokine production (GO:0060907)1.87508834
190negative regulation of vascular permeability (GO:0043116)1.87080058
191regulation of muscle hypertrophy (GO:0014743)1.86967665

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.08628710
2GBX2_23144817_ChIP-Seq_PC3_Human3.22929088
3BP1_19119308_ChIP-ChIP_Hs578T_Human2.67788733
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.64841766
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61711521
6* SMAD_19615063_ChIP-ChIP_OVARY_Human2.40928922
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.39687488
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.35193342
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26605006
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.23266580
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.23266580
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19959198
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17112259
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11668468
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06086650
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02286412
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00393172
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.98527555
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.96094994
20TAF15_26573619_Chip-Seq_HEK293_Human1.95990843
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94653480
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.87468475
23AR_21572438_ChIP-Seq_LNCaP_Human1.87042689
24DROSHA_22980978_ChIP-Seq_HELA_Human1.86386471
25* RARB_27405468_Chip-Seq_BRAIN_Mouse1.80825637
26GATA2_21666600_ChIP-Seq_HMVEC_Human1.78946647
27REST_21632747_ChIP-Seq_MESCs_Mouse1.74321015
28CLOCK_20551151_ChIP-Seq_293T_Human1.73837615
29* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73543238
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.69371773
31GATA1_22025678_ChIP-Seq_K562_Human1.67863561
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.67854631
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.66061763
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.64537237
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.64236330
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63105126
37TBX20_22328084_ChIP-Seq_HEART_Mouse1.61513567
38TBX20_22080862_ChIP-Seq_HEART_Mouse1.61513567
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.60771323
40* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58557057
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55258456
42* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53853689
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.52847416
44SMAD4_21799915_ChIP-Seq_A2780_Human1.51400618
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47439863
46VDR_22108803_ChIP-Seq_LS180_Human1.43575544
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43088339
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42867646
49* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42490174
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.40712095
51P300_19829295_ChIP-Seq_ESCs_Human1.40392287
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38778650
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.38197628
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.37402135
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37313282
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34934232
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34084174
58* REST_18959480_ChIP-ChIP_MESCs_Mouse1.33794961
59ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.32953702
60* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32795335
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32603622
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31968930
63RUNX_20019798_ChIP-Seq_JUKART_Human1.29935269
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.29924486
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29656778
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28777018
67* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27835451
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27334414
69NFIB_24661679_ChIP-Seq_LUNG_Mouse1.26628952
70TP53_16413492_ChIP-PET_HCT116_Human1.26445319
71PPARA_22158963_ChIP-Seq_LIVER_Mouse1.25771829
72* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25651026
73* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25651026
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.24876340
75* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24645618
76EP300_21415370_ChIP-Seq_HL-1_Mouse1.21298396
77* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21080611
78* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20655389
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20632402
80BCAT_22108803_ChIP-Seq_LS180_Human1.20523597
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20392097
82NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19914217
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19195160
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18670988
85* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18536217
86IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17788450
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16774935
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16560866
89KDM2B_26808549_Chip-Seq_K562_Human1.15322975
90AHR_22903824_ChIP-Seq_MCF-7_Human1.15054729
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14440480
92STAT3_23295773_ChIP-Seq_U87_Human1.13868205
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.13530616
94* VDR_24787735_ChIP-Seq_THP-1_Human1.13391138
95FUS_26573619_Chip-Seq_HEK293_Human1.13273492
96* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12315630
97* AR_25329375_ChIP-Seq_VCAP_Human1.11982914
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10889671
99* SOX2_21211035_ChIP-Seq_LN229_Gbm1.10487986
100* GATA1_19941826_ChIP-Seq_K562_Human1.10208276
101CJUN_26792858_Chip-Seq_BT549_Human1.09583705
102EGR1_19374776_ChIP-ChIP_THP-1_Human1.09007007
103PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08719288
104SMAD3_21741376_ChIP-Seq_HESCs_Human1.08401958
105NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.08399537
106* LXR_22158963_ChIP-Seq_LIVER_Mouse1.08118948
107* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07930625
108STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.06616225
109* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06392145
110WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05643527
111* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05331136
112* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05124038
113* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05045613
114* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04549196
115TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04412194
116PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04307188
117VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04233229
118NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04143190
119PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04112164
120TCF7_22412390_ChIP-Seq_EML_Mouse1.04061810
121ZNF274_21170338_ChIP-Seq_K562_Hela1.03848022
122RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03747760
123* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03477191
124IRF8_27001747_Chip-Seq_BMDM_Mouse1.03413209
125NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03285831
126ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03127959
127RXR_22108803_ChIP-Seq_LS180_Human1.02627467
128TP53_18474530_ChIP-ChIP_U2OS_Human1.02616516
129ER_23166858_ChIP-Seq_MCF-7_Human1.01729453
130* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01413303
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01265524
132* RXR_22158963_ChIP-Seq_LIVER_Mouse1.01084489
133TRIM28_21343339_ChIP-Seq_HEK293_Human1.01030974
134TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00789868
135PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00455440
136FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00261411
137TCF4_23295773_ChIP-Seq_U87_Human0.99889077
138FOXA2_19822575_ChIP-Seq_HepG2_Human0.99627261
139* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99511430
140* KDM2B_26808549_Chip-Seq_DND41_Human0.98305852
141GATA1_19941827_ChIP-Seq_MEL_Mouse0.97056581
142* RING1B_27294783_Chip-Seq_ESCs_Mouse0.96396260
143CBX2_27304074_Chip-Seq_ESCs_Mouse0.96361327
144RUNX2_22187159_ChIP-Seq_PCA_Human0.95972206
145SMAD4_21741376_ChIP-Seq_HESCs_Human0.95906625
146* ESR2_21235772_ChIP-Seq_MCF-7_Human0.95438064
147SMAD4_21741376_ChIP-Seq_EPCs_Human0.94925082
148AR_19668381_ChIP-Seq_PC3_Human0.94416083
149EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93721961
150MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93054521
151PRDM14_20953172_ChIP-Seq_ESCs_Human0.93036941
152MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92621950
153FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92508259
154E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.92392732
155SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92012144
156BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91130773
157NANOG_18555785_Chip-Seq_ESCs_Mouse0.90826706
158* RING1B_27294783_Chip-Seq_NPCs_Mouse0.89733690
159* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89681319
160* GATA2_19941826_ChIP-Seq_K562_Human0.89432469
161* FOXO3_23340844_ChIP-Seq_DLD1_Human0.89394522
162TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88905302
163SCL_19346495_ChIP-Seq_HPC-7_Human0.87851550
164LXR_22292898_ChIP-Seq_THP-1_Human0.84756971
165SMC1_22415368_ChIP-Seq_MEFs_Mouse0.84477731
166* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.82244631
167NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80774072
168* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80648607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.31896956
2MP0003880_abnormal_central_pattern4.20482147
3MP0004270_analgesia3.09878275
4MP0003635_abnormal_synaptic_transmissio2.95168803
5MP0008438_abnormal_cutaneous_collagen2.77407894
6MP0009745_abnormal_behavioral_response2.68772881
7MP0002064_seizures2.50368487
8MP0002837_dystrophic_cardiac_calcinosis2.46564095
9MP0004510_myositis2.43248948
10MP0001486_abnormal_startle_reflex2.31813516
11MP0002272_abnormal_nervous_system2.31229280
12* MP0002063_abnormal_learning/memory/cond2.30719838
13MP0009046_muscle_twitch2.22596616
14MP0005275_abnormal_skin_tensile2.18999471
15MP0002822_catalepsy2.14633428
16MP0003329_amyloid_beta_deposits2.12315943
17MP0001440_abnormal_grooming_behavior2.12278859
18MP0004084_abnormal_cardiac_muscle2.12257711
19MP0009780_abnormal_chondrocyte_physiolo2.11323524
20MP0002572_abnormal_emotion/affect_behav2.11057284
21MP0004145_abnormal_muscle_electrophysio2.04608372
22MP0001501_abnormal_sleep_pattern2.02202125
23MP0002332_abnormal_exercise_endurance2.00805145
24MP0001968_abnormal_touch/_nociception1.96490158
25MP0003303_peritoneal_inflammation1.96102007
26MP0003279_aneurysm1.91578673
27MP0003705_abnormal_hypodermis_morpholog1.89449202
28MP0010368_abnormal_lymphatic_system1.86412477
29MP0005670_abnormal_white_adipose1.83522908
30MP0001958_emphysema1.82403409
31MP0003724_increased_susceptibility_to1.81422236
32MP0002139_abnormal_hepatobiliary_system1.80158660
33MP0002734_abnormal_mechanical_nocicepti1.76813134
34MP0004087_abnormal_muscle_fiber1.73817401
35MP0003690_abnormal_glial_cell1.73452684
36MP0003828_pulmonary_edema1.73376599
37MP0000920_abnormal_myelination1.73021976
38MP0004043_abnormal_pH_regulation1.69854056
39MP0003045_fibrosis1.68796471
40MP0003075_altered_response_to1.68701201
41MP0003300_gastrointestinal_ulcer1.64562444
42MP0004885_abnormal_endolymph1.63709723
43MP0003191_abnormal_cellular_cholesterol1.58506818
44MP0005503_abnormal_tendon_morphology1.55511042
45MP0005085_abnormal_gallbladder_physiolo1.55000612
46MP0000759_abnormal_skeletal_muscle1.53208450
47MP0002736_abnormal_nociception_after1.51098707
48MP0003091_abnormal_cell_migration1.48747374
49MP0009840_abnormal_foam_cell1.48368406
50MP0002067_abnormal_sensory_capabilities1.48326665
51MP0003136_yellow_coat_color1.47557437
52MP0005451_abnormal_body_composition1.47316450
53MP0003950_abnormal_plasma_membrane1.45746939
54MP0005166_decreased_susceptibility_to1.45059627
55MP0000751_myopathy1.42569476
56MP0002106_abnormal_muscle_physiology1.41956714
57MP0008004_abnormal_stomach_pH1.40306987
58MP0005165_increased_susceptibility_to1.39775999
59MP0008875_abnormal_xenobiotic_pharmacok1.37487660
60MP0002971_abnormal_brown_adipose1.34542442
61MP0005423_abnormal_somatic_nervous1.33220236
62MP0005360_urolithiasis1.32619212
63MP0004130_abnormal_muscle_cell1.31954483
64MP0002972_abnormal_cardiac_muscle1.31683052
65MP0002998_abnormal_bone_remodeling1.31188557
66MP0000778_abnormal_nervous_system1.30083235
67MP0002733_abnormal_thermal_nociception1.29367730
68MP0003633_abnormal_nervous_system1.29086125
69MP0001970_abnormal_pain_threshold1.28683209
70MP0003195_calcinosis1.28388868
71MP0005375_adipose_tissue_phenotype1.28288173
72MP0005386_behavior/neurological_phenoty1.27035671
73MP0004924_abnormal_behavior1.27035671
74MP0005369_muscle_phenotype1.26950256
75MP0008569_lethality_at_weaning1.23654177
76MP0004142_abnormal_muscle_tone1.22673571
77MP0001851_eye_inflammation1.22637775
78MP0001529_abnormal_vocalization1.22029546
79MP0005551_abnormal_eye_electrophysiolog1.20541134
80MP0004215_abnormal_myocardial_fiber1.20393478
81MP0004036_abnormal_muscle_relaxation1.20239334
82MP0005023_abnormal_wound_healing1.18086727
83MP0000343_altered_response_to1.18042795
84MP0005535_abnormal_body_temperature1.16795779
85MP0004484_altered_response_of1.16121093
86MP0002269_muscular_atrophy1.15951895
87MP0001905_abnormal_dopamine_level1.15556334
88MP0002735_abnormal_chemical_nociception1.15176010
89* MP0002066_abnormal_motor_capabilities/c1.14930671
90MP0003436_decreased_susceptibility_to1.13721668
91MP0005171_absent_coat_pigmentation1.12730549
92MP0005164_abnormal_response_to1.11595835
93MP0005058_abnormal_lysosome_morphology1.11032212
94MP0003631_nervous_system_phenotype1.10761776
95MP0000747_muscle_weakness1.09690119
96MP0002909_abnormal_adrenal_gland1.09672350
97MP0001879_abnormal_lymphatic_vessel1.09146642
98MP0000749_muscle_degeneration1.08811366
99MP0000750_abnormal_muscle_regeneration1.08762324
100MP0008874_decreased_physiological_sensi1.07994125
101MP0005332_abnormal_amino_acid1.07527472
102MP0001533_abnormal_skeleton_physiology1.07265177
103MP0003566_abnormal_cell_adhesion1.07159483
104MP0000955_abnormal_spinal_cord1.07044898
105MP0000013_abnormal_adipose_tissue1.06719151
106MP0001661_extended_life_span1.06606056
107MP0004185_abnormal_adipocyte_glucose1.06578916
108MP0002557_abnormal_social/conspecific_i1.06323172
109MP0005623_abnormal_meninges_morphology1.04866714
110MP0005385_cardiovascular_system_phenoty1.04604426
111MP0001544_abnormal_cardiovascular_syste1.04604426
112MP0005409_darkened_coat_color1.03534366
113MP0002229_neurodegeneration1.03386771
114MP0002933_joint_inflammation1.01277737
115MP0003656_abnormal_erythrocyte_physiolo1.00201504
116MP0005646_abnormal_pituitary_gland0.99817177
117MP0002254_reproductive_system_inflammat0.99747972
118MP0005365_abnormal_bile_salt0.99403216
119MP0002882_abnormal_neuron_morphology0.99336924
120MP0000733_abnormal_muscle_development0.98557062
121MP0004085_abnormal_heartbeat0.98247639
122MP0000604_amyloidosis0.97217463
123MP0001502_abnormal_circadian_rhythm0.96976668
124MP0004947_skin_inflammation0.96902921
125MP0003646_muscle_fatigue0.96857325
126MP0004742_abnormal_vestibular_system0.96494734
127MP0003868_abnormal_feces_composition0.96372201
128MP0003634_abnormal_glial_cell0.95776265
129MP0004272_abnormal_basement_membrane0.95544798
130MP0005620_abnormal_muscle_contractility0.95273662
131MP0003632_abnormal_nervous_system0.94994497
132MP0001485_abnormal_pinna_reflex0.94227795
133MP0010630_abnormal_cardiac_muscle0.93816131
134MP0000249_abnormal_blood_vessel0.93351441
135MP0002184_abnormal_innervation0.93223223
136MP0000767_abnormal_smooth_muscle0.92757567
137MP0002009_preneoplasia0.92222890
138MP0003806_abnormal_nucleotide_metabolis0.91296727
139MP0006082_CNS_inflammation0.90600214
140MP0001177_atelectasis0.90381182
141MP0003879_abnormal_hair_cell0.89740193
142MP0000003_abnormal_adipose_tissue0.89323586
143MP0001984_abnormal_olfaction0.87731724
144MP0004233_abnormal_muscle_weight0.87582543
145MP0006276_abnormal_autonomic_nervous0.86710051
146MP0003137_abnormal_impulse_conducting0.86513639
147MP0010329_abnormal_lipoprotein_level0.86263805
148MP0005595_abnormal_vascular_smooth0.86100071
149MP0004858_abnormal_nervous_system0.85453930
150MP0005167_abnormal_blood-brain_barrier0.84534142
151MP0008775_abnormal_heart_ventricle0.83753053
152MP0005330_cardiomyopathy0.83539782
153MP0003453_abnormal_keratinocyte_physiol0.83373337
154MP0001963_abnormal_hearing_physiology0.82664707
155MP0002118_abnormal_lipid_homeostasis0.81897487
156MP0005666_abnormal_adipose_tissue0.81055479
157MP0002090_abnormal_vision0.79751746
158MP0008872_abnormal_physiological_respon0.79378906
159MP0002295_abnormal_pulmonary_circulatio0.77705350
160MP0002896_abnormal_bone_mineralization0.77301167
161MP0002108_abnormal_muscle_morphology0.75712149
162MP0006138_congestive_heart_failure0.75584147
163MP0002876_abnormal_thyroid_physiology0.74492907
164MP0002133_abnormal_respiratory_system0.72636544
165MP0005388_respiratory_system_phenotype0.72636544

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.49723446
2Type 1 muscle fiber predominance (HP:0003803)4.60398126
3Muscle fiber inclusion bodies (HP:0100299)4.47859971
4Nemaline bodies (HP:0003798)4.42340321
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.33918768
6Focal seizures (HP:0007359)3.91446474
7Myokymia (HP:0002411)3.80944773
8Neurofibrillary tangles (HP:0002185)3.76713766
9Hyperventilation (HP:0002883)3.72702267
10Complement deficiency (HP:0004431)3.64869927
11Cerebral inclusion bodies (HP:0100314)3.63030420
12Aortic aneurysm (HP:0004942)3.50872688
13Asymmetric septal hypertrophy (HP:0001670)3.39443857
14Atonic seizures (HP:0010819)3.39098761
15Visual hallucinations (HP:0002367)3.34779604
16Bundle branch block (HP:0011710)3.32458457
17Increased variability in muscle fiber diameter (HP:0003557)3.23953346
18Systemic lupus erythematosus (HP:0002725)3.17690054
19Abnormality of skeletal muscle fiber size (HP:0012084)3.17122636
20Epileptic encephalopathy (HP:0200134)3.14266091
21Abnormality of complement system (HP:0005339)3.07811612
22Increased connective tissue (HP:0009025)3.02539742
23Scanning speech (HP:0002168)2.89536530
24Distal lower limb muscle weakness (HP:0009053)2.85527479
25Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.84189434
26Degeneration of the lateral corticospinal tracts (HP:0002314)2.84189434
27Absence seizures (HP:0002121)2.83485561
28Dysdiadochokinesis (HP:0002075)2.81567396
29Dialeptic seizures (HP:0011146)2.80535545
30Dysmetria (HP:0001310)2.80200842
31Generalized tonic-clonic seizures (HP:0002069)2.75582278
32Cerebral aneurysm (HP:0004944)2.75234642
33Muscle hypertrophy of the lower extremities (HP:0008968)2.71629614
34Glomerulonephritis (HP:0000099)2.68622679
35Action tremor (HP:0002345)2.68335423
36Broad-based gait (HP:0002136)2.66209209
37Neck muscle weakness (HP:0000467)2.62453755
38Abnormality of the left ventricular outflow tract (HP:0011103)2.61710452
39Subaortic stenosis (HP:0001682)2.61710452
40Centrally nucleated skeletal muscle fibers (HP:0003687)2.60789226
41Abnormality of the corticospinal tract (HP:0002492)2.56264459
42Protrusio acetabuli (HP:0003179)2.55459352
43Round ear (HP:0100830)2.53900120
44Febrile seizures (HP:0002373)2.49491327
45Obstructive sleep apnea (HP:0002870)2.47182209
46Exercise-induced muscle cramps (HP:0003710)2.46117495
47Intention tremor (HP:0002080)2.41916973
48Exercise-induced myalgia (HP:0003738)2.41027889
49Abnormal atrioventricular conduction (HP:0005150)2.40382091
50Increased circulating renin level (HP:0000848)2.38736115
51Gaze-evoked nystagmus (HP:0000640)2.37715677
52Heart block (HP:0012722)2.36703469
53Progressive cerebellar ataxia (HP:0002073)2.36204046
54Aortic dissection (HP:0002647)2.34609970
55Calf muscle hypertrophy (HP:0008981)2.33560401
56Hemiparesis (HP:0001269)2.32213895
57Aplasia involving bones of the upper limbs (HP:0009823)2.29387137
58Aplasia of the phalanges of the hand (HP:0009802)2.29387137
59Aplasia involving bones of the extremities (HP:0009825)2.29387137
60Status epilepticus (HP:0002133)2.27308690
61Anxiety (HP:0000739)2.27205339
62Hyperlipoproteinemia (HP:0010980)2.26973202
63Confusion (HP:0001289)2.23935651
64Ketoacidosis (HP:0001993)2.23293470
65Atrioventricular block (HP:0001678)2.22439771
66Peripheral hypomyelination (HP:0007182)2.18624948
67Poor eye contact (HP:0000817)2.18404484
68Termporal pattern (HP:0011008)2.18311345
69Insidious onset (HP:0003587)2.18311345
70Distal lower limb amyotrophy (HP:0008944)2.17540779
71Xanthomatosis (HP:0000991)2.16604677
72Distal arthrogryposis (HP:0005684)2.16428025
73Amblyopia (HP:0000646)2.16140655
74Supranuclear gaze palsy (HP:0000605)2.15340169
75Intrahepatic cholestasis (HP:0001406)2.14874731
76Ulnar deviation of the wrist (HP:0003049)2.14281928
77Rhabdomyolysis (HP:0003201)2.13914010
78Abnormal social behavior (HP:0012433)2.13040256
79Impaired social interactions (HP:0000735)2.13040256
80Frequent falls (HP:0002359)2.12898786
81Sudden death (HP:0001699)2.12826015
82Ketosis (HP:0001946)2.11925689
83Foot dorsiflexor weakness (HP:0009027)2.11037978
84Hyperglycinemia (HP:0002154)2.10106044
85Abnormality of glycine metabolism (HP:0010895)2.09818796
86Abnormality of serine family amino acid metabolism (HP:0010894)2.09818796
87Mildly elevated creatine phosphokinase (HP:0008180)2.07575772
88Hypoplasia of the iris (HP:0007676)2.06271997
89Sensory axonal neuropathy (HP:0003390)2.06197322
90Deep venous thrombosis (HP:0002625)2.06167585
91Vascular tortuosity (HP:0004948)2.05718535
92Aneurysm (HP:0002617)2.05055476
93Ventricular fibrillation (HP:0001663)2.04791066
94Cerebral hemorrhage (HP:0001342)2.04162956
95Abnormality of the Achilles tendon (HP:0005109)2.03390579
96Bulbar palsy (HP:0001283)2.01987420
97Abnormality of the foot musculature (HP:0001436)2.01907440
98Ventricular arrhythmia (HP:0004308)2.00638372
99Myoglobinuria (HP:0002913)2.00419466
100Generalized myoclonic seizures (HP:0002123)2.00248948
101Myopathic facies (HP:0002058)2.00225621
102Muscle fiber splitting (HP:0003555)1.99608037
103Hyporeflexia of lower limbs (HP:0002600)1.99214240
104Metabolic alkalosis (HP:0200114)1.97927340
105Amyloidosis (HP:0011034)1.97050318
106Polycythemia (HP:0001901)1.96641723
107Abnormality of the calf musculature (HP:0001430)1.96065391
108Achilles tendon contracture (HP:0001771)1.95687540
109Clumsiness (HP:0002312)1.95517372
110Testicular atrophy (HP:0000029)1.95233650
111Myocardial infarction (HP:0001658)1.93934427
112Nephritis (HP:0000123)1.92911821
113Spinal rigidity (HP:0003306)1.92302934
114Epileptiform EEG discharges (HP:0011182)1.91829993
115Dysmetric saccades (HP:0000641)1.91357869
116Interstitial pulmonary disease (HP:0006530)1.91165222
117Arterial tortuosity (HP:0005116)1.91094239
118EMG: neuropathic changes (HP:0003445)1.90500891
119Acute encephalopathy (HP:0006846)1.90479288
120Delusions (HP:0000746)1.89925596
121Abnormality of aromatic amino acid family metabolism (HP:0004338)1.89431433
122Truncal ataxia (HP:0002078)1.88597416
123Hyperkalemia (HP:0002153)1.88002821
124Abnormality of binocular vision (HP:0011514)1.87474990
125Diplopia (HP:0000651)1.87474990
126Hypokalemic alkalosis (HP:0001949)1.87011642
127Absent speech (HP:0001344)1.85551814
128Axonal loss (HP:0003447)1.85002899
129Lower limb amyotrophy (HP:0007210)1.84659204
130Ventricular tachycardia (HP:0004756)1.83542807
131Lipoatrophy (HP:0100578)1.83136195
132Atrial fibrillation (HP:0005110)1.83050927
133Osteolytic defects of the hand bones (HP:0009699)1.81855500
134Osteolytic defects of the phalanges of the hand (HP:0009771)1.81855500
135Hyperglycinuria (HP:0003108)1.81533511
136Hypoplastic ischia (HP:0003175)1.80858638
137Impaired vibration sensation in the lower limbs (HP:0002166)1.79990243
138Acute necrotizing encephalopathy (HP:0006965)1.79684845
139EEG with generalized epileptiform discharges (HP:0011198)1.78648840
140Pheochromocytoma (HP:0002666)1.78237934
141Postural instability (HP:0002172)1.77823106
142Recurrent gram-negative bacterial infections (HP:0005420)1.77595096
143Gout (HP:0001997)1.76597819
144Cerebral edema (HP:0002181)1.76443677
145Abnormality of the ischium (HP:0003174)1.74513750
146Progressive macrocephaly (HP:0004481)1.74287307
147Muscle stiffness (HP:0003552)1.74129907
148EMG: myopathic abnormalities (HP:0003458)1.73398222
149Onion bulb formation (HP:0003383)1.73390251
150Abnormality of monocarboxylic acid metabolism (HP:0010996)1.72940659
151Primary atrial arrhythmia (HP:0001692)1.70999724
152Dysostosis multiplex (HP:0000943)1.70821695
153Prolonged partial thromboplastin time (HP:0003645)1.70806442
154Blue irides (HP:0000635)1.70597517
155Papilledema (HP:0001085)1.69891381
156Megalencephaly (HP:0001355)1.68124810
157Depression (HP:0000716)1.68077574
158Overgrowth (HP:0001548)1.67970128
159Syncope (HP:0001279)1.67612775
160Scapular winging (HP:0003691)1.67146824
161Hypoalphalipoproteinemia (HP:0003233)1.66950738
162Spastic gait (HP:0002064)1.66675482
163Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.66543651
164Abnormal eating behavior (HP:0100738)1.66382082
165Impaired vibratory sensation (HP:0002495)1.65894107
166Difficulty running (HP:0009046)1.65891197
167Increased CSF protein (HP:0002922)1.65831004
168Bronchomalacia (HP:0002780)1.65419960
169Hypsarrhythmia (HP:0002521)1.64696144
170Methylmalonic acidemia (HP:0002912)1.64568978
171Retinal dysplasia (HP:0007973)1.64283318
172Spondylolisthesis (HP:0003302)1.64278281
173Right ventricular cardiomyopathy (HP:0011663)1.63627268
174Abnormality of glycolipid metabolism (HP:0010969)1.63500458
175Abnormality of liposaccharide metabolism (HP:0010968)1.63500458
176Abnormality of glycosphingolipid metabolism (HP:0004343)1.63500458
177Joint hemorrhage (HP:0005261)1.63476941
178Wormian bones (HP:0002645)1.63180496
179Dilatation of the ascending aorta (HP:0005111)1.62867885
180Mitral stenosis (HP:0001718)1.62696392
181Slender build (HP:0001533)1.61456192
182Spontaneous hematomas (HP:0007420)1.61031929

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.91906160
2RIPK13.23224658
3NTRK33.19266820
4TTN3.18821926
5STK392.59667430
6PNCK2.54475155
7OXSR12.42801613
8RIPK42.39121040
9MAP3K42.24578238
10MAP3K92.22770887
11MYLK2.16560558
12NTRK12.04144486
13MAP2K42.01157011
14CASK2.00940404
15DAPK21.90807090
16TGFBR21.77618267
17TRPM71.72162618
18MAP2K71.66328796
19MUSK1.60252068
20MINK11.57964748
21GRK51.57351380
22TNIK1.51555816
23MAP3K31.51128915
24BMPR21.47885130
25PAK61.45847717
26WNK41.44880938
27PIK3CG1.43889006
28PINK11.42948568
29JAK11.39117745
30FES1.38272889
31NME11.37160289
32PDGFRA1.36791543
33KSR21.35177303
34MAP2K31.34984995
35ERN11.33541123
36PTK2B1.32231036
37SGK31.29497003
38PLK21.29492427
39CAMK2B1.28992264
40MAPK71.28719188
41CAMK2A1.27243181
42TYRO31.26835909
43SGK21.25899046
44PRKD31.23900967
45FGR1.23587423
46FGFR31.23258895
47TRIB31.21799173
48MAP3K21.19009648
49MOS1.15876031
50PHKG11.11710817
51PHKG21.11710817
52FER1.11529764
53CDK51.11381921
54EPHA31.11275024
55MAP3K121.09969980
56CAMK2D1.08031675
57AKT31.07363195
58PKN11.07244815
59BLK1.06425021
60CDC42BPA1.06299985
61TYK21.03068288
62SGK2231.02954624
63SGK4941.02954624
64INSRR1.00853935
65NEK91.00726660
66EEF2K1.00239124
67MAP3K140.99736760
68ZAP700.99714425
69FGFR20.96540808
70PDK20.93065498
71PRKAA20.92763494
72PRKCG0.92079839
73CAMK2G0.90082439
74PDGFRB0.89761986
75PRKCE0.88276712
76PDPK10.88129194
77NTRK20.87317023
78PRPF4B0.86510204
79MAPKAPK50.86324510
80DMPK0.85537293
81TBK10.85356964
82FGFR40.85104971
83NLK0.84542827
84CDK190.84534436
85EPHB10.82946864
86NEK60.82064727
87JAK20.81673471
88TAOK20.80558349
89MAPK40.80307020
90PAK30.79962080
91PDK30.79880826
92PDK40.79880826
93MET0.77742213
94HIPK20.77233487
95STK380.77203815
96ROCK20.77070342
97SIK10.76792682
98BCKDK0.76239324
99WNK10.75932576
100CAMKK20.75897289
101MAP3K130.74907086
102BCR0.73797496
103IRAK30.73135350
104STK110.72862055
105SGK10.70916221
106IKBKE0.68905441
107OBSCN0.68888788
108GRK70.67746714
109PAK20.66726649
110CAMK40.66487770
111MAPK150.65613750
112KSR10.64556660
113CAMK10.64148164
114ARAF0.64093749
115CAMKK10.63816002
116PDK10.63276060
117CAMK1G0.62484751
118UHMK10.59949402
119TIE10.59023287
120MARK10.58507471
121MAP3K60.57571930
122DYRK1A0.57051701
123MAP3K70.56122616
124DAPK10.56112498
125CSK0.56041983
126DDR20.55707652
127MARK20.55112118
128ABL20.54912744
129MAPK120.54729469
130MAPKAPK30.54300969
131RET0.53340320
132PRKACA0.53093430
133WNK30.52709810
134PRKD20.52093860
135MAP2K10.50430222
136GSK3A0.50102359
137MAPK110.49729334
138CDK140.48693102
139ICK0.48497663
140LATS20.48214013
141MAP3K10.47554851
142MAPK130.47482725
143PRKD10.47217478
144PIK3CA0.46917087
145PRKCH0.46437909
146MAPK100.45267739
147IRAK10.45140708
148RPS6KA20.44932472
149ROCK10.44382290

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.20120722
2Nicotine addiction_Homo sapiens_hsa050332.47456591
3Glutamatergic synapse_Homo sapiens_hsa047242.03646043
4GABAergic synapse_Homo sapiens_hsa047271.96712803
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.95234205
6Long-term potentiation_Homo sapiens_hsa047201.92973420
7Amphetamine addiction_Homo sapiens_hsa050311.84240094
8Salivary secretion_Homo sapiens_hsa049701.83041006
9Circadian entrainment_Homo sapiens_hsa047131.82299642
10Circadian rhythm_Homo sapiens_hsa047101.66775567
11Morphine addiction_Homo sapiens_hsa050321.62395343
12Synaptic vesicle cycle_Homo sapiens_hsa047211.60359181
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.57022840
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.56559138
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55323840
16Renin secretion_Homo sapiens_hsa049241.55264855
17Gastric acid secretion_Homo sapiens_hsa049711.48516738
18Butanoate metabolism_Homo sapiens_hsa006501.47324013
19Arginine biosynthesis_Homo sapiens_hsa002201.44780012
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.41240119
21Insulin secretion_Homo sapiens_hsa049111.38531381
22Dopaminergic synapse_Homo sapiens_hsa047281.37692448
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37353269
24Long-term depression_Homo sapiens_hsa047301.36035834
25Taste transduction_Homo sapiens_hsa047421.35929101
26Propanoate metabolism_Homo sapiens_hsa006401.35400911
27Oxidative phosphorylation_Homo sapiens_hsa001901.35019951
28Collecting duct acid secretion_Homo sapiens_hsa049661.34739481
29Staphylococcus aureus infection_Homo sapiens_hsa051501.33127750
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.32338861
31Olfactory transduction_Homo sapiens_hsa047401.31062624
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30712213
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.29402612
34Cardiac muscle contraction_Homo sapiens_hsa042601.28239929
35Calcium signaling pathway_Homo sapiens_hsa040201.28121545
36Adipocytokine signaling pathway_Homo sapiens_hsa049201.27975836
37Serotonergic synapse_Homo sapiens_hsa047261.27617773
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26021969
39Malaria_Homo sapiens_hsa051441.22837170
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22296158
41Fatty acid elongation_Homo sapiens_hsa000621.20978787
42Osteoclast differentiation_Homo sapiens_hsa043801.20420425
43Cholinergic synapse_Homo sapiens_hsa047251.17316813
44Alzheimers disease_Homo sapiens_hsa050101.16172201
45Amoebiasis_Homo sapiens_hsa051461.14593882
46Oxytocin signaling pathway_Homo sapiens_hsa049211.14477500
47Insulin resistance_Homo sapiens_hsa049311.14444537
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.14074030
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12145109
50Pertussis_Homo sapiens_hsa051331.11908225
51Bile secretion_Homo sapiens_hsa049761.11873076
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11064246
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.10145969
54Focal adhesion_Homo sapiens_hsa045101.03724331
55ECM-receptor interaction_Homo sapiens_hsa045121.03484893
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02250955
57Sulfur metabolism_Homo sapiens_hsa009201.01508279
58Fatty acid metabolism_Homo sapiens_hsa012120.99317118
59Cocaine addiction_Homo sapiens_hsa050300.97936597
60Fatty acid degradation_Homo sapiens_hsa000710.97921710
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.97419218
62Fatty acid biosynthesis_Homo sapiens_hsa000610.96694589
63TNF signaling pathway_Homo sapiens_hsa046680.92149299
64VEGF signaling pathway_Homo sapiens_hsa043700.92082444
65GnRH signaling pathway_Homo sapiens_hsa049120.91608245
66Pancreatic secretion_Homo sapiens_hsa049720.91310930
67cAMP signaling pathway_Homo sapiens_hsa040240.90106678
68Platelet activation_Homo sapiens_hsa046110.89290494
69Insulin signaling pathway_Homo sapiens_hsa049100.87647087
70PPAR signaling pathway_Homo sapiens_hsa033200.87438509
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84681285
72Other glycan degradation_Homo sapiens_hsa005110.84051281
73Gap junction_Homo sapiens_hsa045400.83966258
74Parkinsons disease_Homo sapiens_hsa050120.82892567
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82305605
76Phototransduction_Homo sapiens_hsa047440.81479952
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80520024
78Leishmaniasis_Homo sapiens_hsa051400.79033374
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78632714
80Renal cell carcinoma_Homo sapiens_hsa052110.78297894
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78083806
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78055367
83FoxO signaling pathway_Homo sapiens_hsa040680.77583481
84Glioma_Homo sapiens_hsa052140.76700345
85mTOR signaling pathway_Homo sapiens_hsa041500.76154943
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76089535
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75926829
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75851705
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.75678494
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74742688
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.74647483
92Tryptophan metabolism_Homo sapiens_hsa003800.74222641
93Histidine metabolism_Homo sapiens_hsa003400.74110875
94Toxoplasmosis_Homo sapiens_hsa051450.73648651
95Pyruvate metabolism_Homo sapiens_hsa006200.72883274
96Mineral absorption_Homo sapiens_hsa049780.70992676
97Dorso-ventral axis formation_Homo sapiens_hsa043200.70642813
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70327706
99Axon guidance_Homo sapiens_hsa043600.70034286
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.69640341
101Vibrio cholerae infection_Homo sapiens_hsa051100.69084751
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69027315
103MAPK signaling pathway_Homo sapiens_hsa040100.68751481
104Estrogen signaling pathway_Homo sapiens_hsa049150.68409835
105Acute myeloid leukemia_Homo sapiens_hsa052210.67973330
106AMPK signaling pathway_Homo sapiens_hsa041520.67947821
107ABC transporters_Homo sapiens_hsa020100.67887939
108Peroxisome_Homo sapiens_hsa041460.66687600
109B cell receptor signaling pathway_Homo sapiens_hsa046620.66317542
110Melanogenesis_Homo sapiens_hsa049160.66262165
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65884559
112Dilated cardiomyopathy_Homo sapiens_hsa054140.65108117
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64284295
114Ether lipid metabolism_Homo sapiens_hsa005650.64249411
115Tuberculosis_Homo sapiens_hsa051520.63775629
116Thyroid hormone synthesis_Homo sapiens_hsa049180.63515989
117Steroid biosynthesis_Homo sapiens_hsa001000.61570596
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61259331
119Prolactin signaling pathway_Homo sapiens_hsa049170.61146720
120Glucagon signaling pathway_Homo sapiens_hsa049220.60161522
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59771902
122Vitamin B6 metabolism_Homo sapiens_hsa007500.59143972
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58792873
124Type II diabetes mellitus_Homo sapiens_hsa049300.57634147
125Chronic myeloid leukemia_Homo sapiens_hsa052200.56994745
126Choline metabolism in cancer_Homo sapiens_hsa052310.56666492
127Proteoglycans in cancer_Homo sapiens_hsa052050.56107711
128African trypanosomiasis_Homo sapiens_hsa051430.56046964
129Glycerolipid metabolism_Homo sapiens_hsa005610.55978620
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55328905
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54785403
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54717290
133HIF-1 signaling pathway_Homo sapiens_hsa040660.54182445
134Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53625537
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.53540103
136Arginine and proline metabolism_Homo sapiens_hsa003300.53465601
137Complement and coagulation cascades_Homo sapiens_hsa046100.53233429
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52424286
139ErbB signaling pathway_Homo sapiens_hsa040120.51428375
140Chemical carcinogenesis_Homo sapiens_hsa052040.51349676
141Phenylalanine metabolism_Homo sapiens_hsa003600.51301280
142Tyrosine metabolism_Homo sapiens_hsa003500.50143446
143Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49923256
144Lysosome_Homo sapiens_hsa041420.49228732
145Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48214272
146Prion diseases_Homo sapiens_hsa050200.47946750
147Inositol phosphate metabolism_Homo sapiens_hsa005620.47223172
148Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46562202
149Glycerophospholipid metabolism_Homo sapiens_hsa005640.46368740
150Huntingtons disease_Homo sapiens_hsa050160.46207463
151Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46083265

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