KLHDC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of mitochondrial fission (GO:0090141)5.37632832
2pyrimidine nucleobase catabolic process (GO:0006208)5.02942779
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.52641606
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.24798425
5nucleobase catabolic process (GO:0046113)4.23002839
6response to pheromone (GO:0019236)4.22869769
7synaptic vesicle exocytosis (GO:0016079)4.09908222
8synaptic vesicle maturation (GO:0016188)4.07118630
9neuronal action potential propagation (GO:0019227)4.03673183
10regulation of synaptic vesicle exocytosis (GO:2000300)3.83565922
11layer formation in cerebral cortex (GO:0021819)3.82630066
12synaptic vesicle docking involved in exocytosis (GO:0016081)3.69984660
13iron-sulfur cluster assembly (GO:0016226)3.66750642
14metallo-sulfur cluster assembly (GO:0031163)3.66750642
15neuron cell-cell adhesion (GO:0007158)3.66414428
16glutamate secretion (GO:0014047)3.64889081
17vocalization behavior (GO:0071625)3.62827884
18protein localization to synapse (GO:0035418)3.61528000
19regulation of synaptic vesicle transport (GO:1902803)3.60810456
20regulation of mitochondrial fission (GO:0090140)3.57164416
21locomotory exploration behavior (GO:0035641)3.56735911
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.46083488
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.41723838
24ribonucleoprotein complex disassembly (GO:0032988)3.35114859
25regulation of glutamate receptor signaling pathway (GO:1900449)3.19144947
26exploration behavior (GO:0035640)3.16608987
27axonal fasciculation (GO:0007413)3.15260930
28response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.12595996
29positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.12550207
30neuron recognition (GO:0008038)3.12024460
31neurotransmitter secretion (GO:0007269)3.11486614
32cell migration in hindbrain (GO:0021535)3.10369198
33succinate metabolic process (GO:0006105)3.08655091
34regulation of sarcomere organization (GO:0060297)3.04255590
35RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.03181500
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.03181500
37negative regulation of microtubule polymerization (GO:0031115)3.00204223
38ubiquinone biosynthetic process (GO:0006744)2.99873940
39cerebellar Purkinje cell differentiation (GO:0021702)2.98444106
40cell communication by electrical coupling (GO:0010644)2.98189125
41ubiquinone metabolic process (GO:0006743)2.97640516
42dendrite morphogenesis (GO:0048813)2.97288031
43innervation (GO:0060384)2.94779284
44postsynaptic membrane organization (GO:0001941)2.93910658
45nonmotile primary cilium assembly (GO:0035058)2.93422531
46regulation of synapse structural plasticity (GO:0051823)2.89932950
47behavioral response to nicotine (GO:0035095)2.89452897
48pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.89235296
49regulation of neuronal synaptic plasticity (GO:0048168)2.87794509
50positive regulation of synapse maturation (GO:0090129)2.87579760
51regulation of relaxation of muscle (GO:1901077)2.86823244
52quinone biosynthetic process (GO:1901663)2.86228749
53cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.85596783
54calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.85251271
55organelle disassembly (GO:1903008)2.84980913
56L-methionine salvage (GO:0071267)2.83861050
57L-methionine biosynthetic process (GO:0071265)2.83861050
58amino acid salvage (GO:0043102)2.83861050
59regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.82865660
60protein polyglutamylation (GO:0018095)2.82810051
61dendritic spine morphogenesis (GO:0060997)2.82035902
62regulation of long-term neuronal synaptic plasticity (GO:0048169)2.82009487
63peptidyl-arginine N-methylation (GO:0035246)2.81925124
64peptidyl-arginine methylation (GO:0018216)2.81925124
65righting reflex (GO:0060013)2.81714826
66epithelial cell differentiation involved in kidney development (GO:0035850)2.80684192
67sequestering of actin monomers (GO:0042989)2.76523351
68ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.73337947
69pyrimidine nucleotide catabolic process (GO:0006244)2.73287144
70synaptic transmission, glutamatergic (GO:0035249)2.71674717
71establishment of mitochondrion localization (GO:0051654)2.68882765
72regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.68773043
73chaperone-mediated protein transport (GO:0072321)2.68614612
74establishment of nucleus localization (GO:0040023)2.68334226
75gamma-aminobutyric acid transport (GO:0015812)2.68146322
76glutamate receptor signaling pathway (GO:0007215)2.67906150
77positive regulation of potassium ion transmembrane transport (GO:1901381)2.67524982
78proline transport (GO:0015824)2.67126392
79central nervous system projection neuron axonogenesis (GO:0021952)2.66828713
80daunorubicin metabolic process (GO:0044597)2.65815801
81polyketide metabolic process (GO:0030638)2.65815801
82doxorubicin metabolic process (GO:0044598)2.65815801
83regulation of hexokinase activity (GO:1903299)2.64649732
84regulation of glucokinase activity (GO:0033131)2.64649732
85pyrimidine dimer repair (GO:0006290)2.64502760
86neuron-neuron synaptic transmission (GO:0007270)2.64102857
87ionotropic glutamate receptor signaling pathway (GO:0035235)2.64072862
88regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.62802685
89negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.62302737
90regulation of development, heterochronic (GO:0040034)2.61863418
91positive regulation of dendritic spine morphogenesis (GO:0061003)2.60868586
92protein complex biogenesis (GO:0070271)2.60640369
93DNA integration (GO:0015074)2.59134641
94base-excision repair, AP site formation (GO:0006285)2.59122814
95membrane depolarization during action potential (GO:0086010)2.58860694
96regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.58380606
97peptidyl-arginine omega-N-methylation (GO:0035247)2.58263493
98protein-cofactor linkage (GO:0018065)2.58023628
99regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.57955839
100deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.56950050
101neurotransmitter-gated ion channel clustering (GO:0072578)2.56936490
102neurotransmitter biosynthetic process (GO:0042136)2.56823079
103protein localization to cilium (GO:0061512)2.56546217
104positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.56147423
105mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.56147423
106C4-dicarboxylate transport (GO:0015740)2.55035313
107hippocampus development (GO:0021766)2.53620078
108negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.52954593
109negative regulation of calcium ion transmembrane transport (GO:1903170)2.52954593
110peroxisome fission (GO:0016559)2.52875786
111intraspecies interaction between organisms (GO:0051703)2.52576654
112social behavior (GO:0035176)2.52576654
113activation of protein kinase A activity (GO:0034199)2.52552537
114synaptic vesicle endocytosis (GO:0048488)2.52463213
115L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.51991289
116G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.50919726
117synapse assembly (GO:0007416)2.50836980
118regulation of skeletal muscle contraction (GO:0014819)2.50459098
119regulation of dendritic spine morphogenesis (GO:0061001)2.49999359
120short-chain fatty acid metabolic process (GO:0046459)2.49499647
121negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.49231491
122dicarboxylic acid catabolic process (GO:0043649)2.48676897
123cerebellum development (GO:0021549)2.48634399
124positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.47651893
125neurotransmitter transport (GO:0006836)2.47371053
126regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.46966788
127organelle transport along microtubule (GO:0072384)2.46930994
128glyoxylate metabolic process (GO:0046487)2.45428697
129microtubule severing (GO:0051013)2.45326200
130regulation of meiosis (GO:0040020)2.45253778
131membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.43956533
132mitochondrial respiratory chain complex I assembly (GO:0032981)2.43660704
133NADH dehydrogenase complex assembly (GO:0010257)2.43660704
134mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.43660704
135regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.42719638
136regulation of cAMP-dependent protein kinase activity (GO:2000479)2.42517341
137presynaptic membrane organization (GO:0097090)2.41889110
138auditory behavior (GO:0031223)2.41010774
139regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.40893283
140quinone metabolic process (GO:1901661)2.40797472
141cerebellar Purkinje cell layer development (GO:0021680)2.40563001
142detection of light stimulus involved in sensory perception (GO:0050962)2.40482370
143detection of light stimulus involved in visual perception (GO:0050908)2.40482370
144positive regulation of membrane potential (GO:0045838)2.39406805
145positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.39378597
146regulation of calcium ion-dependent exocytosis (GO:0017158)2.39069990
147lipid particle organization (GO:0034389)2.38854449
148regulation of neurotransmitter secretion (GO:0046928)2.38758804
149S-adenosylmethionine metabolic process (GO:0046500)2.38469717
150regulation of membrane repolarization (GO:0060306)2.37987202
151long-term memory (GO:0007616)2.35733769
152aminoglycoside antibiotic metabolic process (GO:0030647)2.34677338
153regulation of respiratory system process (GO:0044065)2.34550014
154positive regulation of neurotransmitter secretion (GO:0001956)2.34511606
155regulation of cilium movement (GO:0003352)2.34474742
156regulation of cell communication by electrical coupling (GO:0010649)2.34045634
157establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.31777645
158mitochondrion transport along microtubule (GO:0047497)2.31777645
159mitochondrial respiratory chain complex assembly (GO:0033108)2.31622518
160behavioral defense response (GO:0002209)2.31196624
161behavioral fear response (GO:0001662)2.31196624
162photoreceptor cell maintenance (GO:0045494)2.30817236
163regulation of potassium ion transmembrane transport (GO:1901379)2.30235011
164intraciliary transport (GO:0042073)2.29581271
165actin-myosin filament sliding (GO:0033275)2.29066318
166muscle filament sliding (GO:0030049)2.29066318
167axon cargo transport (GO:0008088)2.29037370
168regulation of vesicle fusion (GO:0031338)2.28709013
169synaptic vesicle transport (GO:0048489)2.27555313
170establishment of synaptic vesicle localization (GO:0097480)2.27555313
171regulation of neurotransmitter levels (GO:0001505)2.27073677
172presynaptic membrane assembly (GO:0097105)2.26955194
173regulation of potassium ion transmembrane transporter activity (GO:1901016)2.25841811
174negative regulation of hormone biosynthetic process (GO:0032353)2.25652624
175negative regulation of hormone metabolic process (GO:0032351)2.25652624
176synapse organization (GO:0050808)2.25181857
177regulation of neurotransmitter transport (GO:0051588)2.24720198
178detection of calcium ion (GO:0005513)2.24412155
179branched-chain amino acid catabolic process (GO:0009083)2.23910404
180glycosphingolipid biosynthetic process (GO:0006688)2.23887191
181negative regulation of cation channel activity (GO:2001258)2.23578448
182short-term memory (GO:0007614)2.23371847
183axoneme assembly (GO:0035082)2.22191305

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.36890028
2GBX2_23144817_ChIP-Seq_PC3_Human2.92785243
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.73819058
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64973304
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.57115204
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.39850656
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.38432600
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.31906931
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.30782818
10IGF1R_20145208_ChIP-Seq_DFB_Human2.28693748
11VDR_22108803_ChIP-Seq_LS180_Human2.24879362
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24434485
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22329504
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22329504
15IRF1_19129219_ChIP-ChIP_H3396_Human2.20693377
16REST_21632747_ChIP-Seq_MESCs_Mouse2.19475362
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16410684
18ZNF274_21170338_ChIP-Seq_K562_Hela2.10854752
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07753820
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91857688
21* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90032817
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89714628
23REST_18959480_ChIP-ChIP_MESCs_Mouse1.87081016
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.87063547
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.87056694
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86468647
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.85681050
28* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82478444
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82027882
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.79263305
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.77535501
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.77160610
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.73818716
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64609820
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63509722
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.57483333
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56709470
38TAF15_26573619_Chip-Seq_HEK293_Human1.55213428
39FUS_26573619_Chip-Seq_HEK293_Human1.53889320
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51519054
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51090626
42RNF2_27304074_Chip-Seq_NSC_Mouse1.49578111
43TP53_22573176_ChIP-Seq_HFKS_Human1.48994696
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45972290
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43696357
46SMAD4_21799915_ChIP-Seq_A2780_Human1.43293053
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42805893
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.42192445
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.40013722
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38579791
51GABP_17652178_ChIP-ChIP_JURKAT_Human1.37776333
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36925084
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36034357
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35924250
55TAL1_26923725_Chip-Seq_HPCs_Mouse1.34967740
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32861904
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31965747
58AR_21572438_ChIP-Seq_LNCaP_Human1.29554497
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29417067
60CBP_20019798_ChIP-Seq_JUKART_Human1.29417067
61ER_23166858_ChIP-Seq_MCF-7_Human1.29311913
62P300_19829295_ChIP-Seq_ESCs_Human1.29003550
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28650818
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.28276732
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27290185
66DROSHA_22980978_ChIP-Seq_HELA_Human1.27170640
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25862735
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24374217
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.23790653
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.23341173
71* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22537768
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.21547805
73STAT3_23295773_ChIP-Seq_U87_Human1.21285692
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19752180
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19167679
76VDR_23849224_ChIP-Seq_CD4+_Human1.18927949
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17939537
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17929769
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17795621
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16140450
81SRF_21415370_ChIP-Seq_HL-1_Mouse1.15867991
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14905274
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14775340
84HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14143539
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12994736
86AR_25329375_ChIP-Seq_VCAP_Human1.12913327
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12587403
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11458292
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11458292
90BCAT_22108803_ChIP-Seq_LS180_Human1.11325433
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09747064
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.07109255
93RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06947070
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06757355
95KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06691076
96AR_19668381_ChIP-Seq_PC3_Human1.05819019
97NCOR_22424771_ChIP-Seq_293T_Human1.05722183
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05663363
99EWS_26573619_Chip-Seq_HEK293_Human1.05467542
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05460796
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.05191498
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03509362
103TCF4_23295773_ChIP-Seq_U87_Human1.02007113
104OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01013677
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99919769
106GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99122138
107* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98490693
108RING1B_27294783_Chip-Seq_NPCs_Mouse0.98361069
109SOX9_26525672_Chip-Seq_HEART_Mouse0.98311198
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98226569
111FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98152549
112MYC_18940864_ChIP-ChIP_HL60_Human0.97679634
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97377963
114REST_19997604_ChIP-ChIP_NEURONS_Mouse0.97059748
115HTT_18923047_ChIP-ChIP_STHdh_Human0.97046232
116PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97015185
117ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96430835
118POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96229289
119EP300_21415370_ChIP-Seq_HL-1_Mouse0.95664397
120* JUN_21703547_ChIP-Seq_K562_Human0.95161798
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94045165
122PIAS1_25552417_ChIP-Seq_VCAP_Human0.93312112
123ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93205392
124NANOG_19829295_ChIP-Seq_ESCs_Human0.93156738
125SOX2_19829295_ChIP-Seq_ESCs_Human0.93156738
126TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92780106
127P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92760469
128CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92573793
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92101579
130FLI1_21867929_ChIP-Seq_TH2_Mouse0.91917210
131KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91799495
132RUNX2_22187159_ChIP-Seq_PCA_Human0.91666107
133IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91576026
134NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91488835
135CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91139091
136* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90984903
137FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90718193
138FOXA1_25329375_ChIP-Seq_VCAP_Human0.90718193
139NANOG_18555785_Chip-Seq_ESCs_Mouse0.90469402
140* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90418918
141SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89833483
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89727658
143PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89015169
144EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88790956
145P53_22387025_ChIP-Seq_ESCs_Mouse0.87970429
146CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.87729173
147TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86419079
148NFE2_27457419_Chip-Seq_LIVER_Mouse0.80550002
149EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.80491180

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.09182532
2MP0003880_abnormal_central_pattern3.65818837
3MP0004270_analgesia2.98110306
4MP0003635_abnormal_synaptic_transmissio2.80704775
5MP0003646_muscle_fatigue2.69372455
6MP0006276_abnormal_autonomic_nervous2.53950905
7MP0004147_increased_porphyrin_level2.53778658
8MP0002102_abnormal_ear_morphology2.29673527
9MP0003787_abnormal_imprinting2.21283696
10MP0002822_catalepsy2.16230692
11MP0002063_abnormal_learning/memory/cond2.15700170
12MP0003122_maternal_imprinting2.15221080
13MP0001968_abnormal_touch/_nociception2.09585111
14MP0002734_abnormal_mechanical_nocicepti2.09185112
15MP0005423_abnormal_somatic_nervous2.01494654
16MP0004145_abnormal_muscle_electrophysio1.92005765
17MP0000751_myopathy1.88964596
18MP0009745_abnormal_behavioral_response1.85909561
19MP0002837_dystrophic_cardiac_calcinosis1.85470147
20MP0003123_paternal_imprinting1.84717812
21MP0002184_abnormal_innervation1.83789971
22MP0000778_abnormal_nervous_system1.82594070
23MP0003121_genomic_imprinting1.81758294
24MP0008877_abnormal_DNA_methylation1.74455489
25MP0009046_muscle_twitch1.71044275
26MP0002572_abnormal_emotion/affect_behav1.67443362
27MP0002064_seizures1.65957944
28MP0002736_abnormal_nociception_after1.63716746
29MP0005085_abnormal_gallbladder_physiolo1.60564285
30MP0002272_abnormal_nervous_system1.59389553
31MP0003221_abnormal_cardiomyocyte_apopto1.56627732
32MP0002067_abnormal_sensory_capabilities1.53827664
33MP0001529_abnormal_vocalization1.52437701
34MP0005646_abnormal_pituitary_gland1.50612966
35MP0002735_abnormal_chemical_nociception1.47960084
36MP0001486_abnormal_startle_reflex1.47389584
37MP0004215_abnormal_myocardial_fiber1.47085037
38MP0002653_abnormal_ependyma_morphology1.46935980
39MP0004084_abnormal_cardiac_muscle1.46759976
40MP0000955_abnormal_spinal_cord1.46449697
41MP0002733_abnormal_thermal_nociception1.45486842
42MP0005253_abnormal_eye_physiology1.39282377
43MP0005187_abnormal_penis_morphology1.38591225
44MP0004233_abnormal_muscle_weight1.36708741
45MP0002557_abnormal_social/conspecific_i1.36423704
46MP0004924_abnormal_behavior1.35921610
47MP0005386_behavior/neurological_phenoty1.35921610
48MP0002139_abnormal_hepatobiliary_system1.35758069
49MP0002909_abnormal_adrenal_gland1.35440627
50MP0001986_abnormal_taste_sensitivity1.34079300
51MP0004811_abnormal_neuron_physiology1.33886586
52MP0005551_abnormal_eye_electrophysiolog1.33763385
53MP0006292_abnormal_olfactory_placode1.31275055
54MP0002876_abnormal_thyroid_physiology1.31259548
55MP0001970_abnormal_pain_threshold1.31084609
56MP0004133_heterotaxia1.30790621
57MP0005645_abnormal_hypothalamus_physiol1.29207371
58MP0001299_abnormal_eye_distance/1.27310862
59MP0002882_abnormal_neuron_morphology1.23884470
60MP0004043_abnormal_pH_regulation1.23475179
61MP0006072_abnormal_retinal_apoptosis1.23039738
62MP0002638_abnormal_pupillary_reflex1.22254990
63MP0000631_abnormal_neuroendocrine_gland1.20050306
64MP0000569_abnormal_digit_pigmentation1.19109973
65MP0000013_abnormal_adipose_tissue1.18284998
66MP0003011_delayed_dark_adaptation1.16837650
67MP0005365_abnormal_bile_salt1.16381970
68MP0002152_abnormal_brain_morphology1.14188907
69MP0001440_abnormal_grooming_behavior1.12908442
70MP0003195_calcinosis1.12362379
71MP0003567_abnormal_fetal_cardiomyocyte1.11724198
72MP0008569_lethality_at_weaning1.09709169
73MP0003861_abnormal_nervous_system1.09258327
74MP0002066_abnormal_motor_capabilities/c1.08074717
75MP0009780_abnormal_chondrocyte_physiolo1.07558819
76MP0001984_abnormal_olfaction1.07552806
77MP0001502_abnormal_circadian_rhythm1.07074468
78MP0003890_abnormal_embryonic-extraembry1.06828643
79MP0003137_abnormal_impulse_conducting1.05507888
80MP0005394_taste/olfaction_phenotype1.02071125
81MP0005499_abnormal_olfactory_system1.02071125
82MP0001188_hyperpigmentation1.00898370
83MP0008995_early_reproductive_senescence1.00229194
84MP0008789_abnormal_olfactory_epithelium0.97095378
85MP0005084_abnormal_gallbladder_morpholo0.95965015
86MP0002127_abnormal_cardiovascular_syste0.95624633
87MP0001905_abnormal_dopamine_level0.94428018
88MP0009384_cardiac_valve_regurgitation0.93258234
89MP0003283_abnormal_digestive_organ0.91306615
90MP0004085_abnormal_heartbeat0.91151862
91MP0005360_urolithiasis0.89130082
92MP0002752_abnormal_somatic_nervous0.88799045
93MP0004036_abnormal_muscle_relaxation0.88784053
94MP0006036_abnormal_mitochondrial_physio0.87809177
95MP0005369_muscle_phenotype0.87139542
96MP0005332_abnormal_amino_acid0.86492525
97MP0001764_abnormal_homeostasis0.86232508
98MP0000465_gastrointestinal_hemorrhage0.86075390
99MP0001501_abnormal_sleep_pattern0.84832204
100MP0000026_abnormal_inner_ear0.84437863
101MP0003315_abnormal_perineum_morphology0.83511521
102MP0002234_abnormal_pharynx_morphology0.82369166
103MP0005620_abnormal_muscle_contractility0.82137053
104MP0003937_abnormal_limbs/digits/tail_de0.81771484
105MP0004858_abnormal_nervous_system0.81686806
106MP0000759_abnormal_skeletal_muscle0.79817965
107MP0003119_abnormal_digestive_system0.79616838
108MP0008875_abnormal_xenobiotic_pharmacok0.77658199
109MP0003942_abnormal_urinary_system0.77594117
110MP0000747_muscle_weakness0.77547598
111MP0003385_abnormal_body_wall0.76306027
112MP0002106_abnormal_muscle_physiology0.76086838
113MP0010329_abnormal_lipoprotein_level0.76069372
114MP0003329_amyloid_beta_deposits0.76035123
115MP0002751_abnormal_autonomic_nervous0.75587524
116MP0002938_white_spotting0.75500388
117MP0008872_abnormal_physiological_respon0.75340769
118MP0004484_altered_response_of0.74923759
119MP0010386_abnormal_urinary_bladder0.74512502
120MP0002163_abnormal_gland_morphology0.74329187
121MP0009250_abnormal_appendicular_skeleto0.73772750
122MP0004130_abnormal_muscle_cell0.73647806
123MP0002160_abnormal_reproductive_system0.73548974
124MP0000749_muscle_degeneration0.72059079
125MP0004142_abnormal_muscle_tone0.71912943
126MP0000534_abnormal_ureter_morphology0.70711769
127MP0003879_abnormal_hair_cell0.70338973
128MP0001944_abnormal_pancreas_morphology0.69228349
129MP0004885_abnormal_endolymph0.68824910
130MP0002249_abnormal_larynx_morphology0.68324406
131MP0000049_abnormal_middle_ear0.66717188
132MP0004087_abnormal_muscle_fiber0.64757464

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.43454107
2Medial flaring of the eyebrow (HP:0010747)3.77302478
3Congenital primary aphakia (HP:0007707)3.60996158
4Exercise-induced muscle cramps (HP:0003710)3.52377776
5Visual hallucinations (HP:0002367)3.49653161
6Nephrogenic diabetes insipidus (HP:0009806)3.42173383
7Myokymia (HP:0002411)3.39262938
8Focal seizures (HP:0007359)3.37403013
9Atonic seizures (HP:0010819)3.28270421
10Shoulder girdle muscle weakness (HP:0003547)3.20678216
11Epileptic encephalopathy (HP:0200134)2.98376733
12Hyperventilation (HP:0002883)2.96470841
13Hyperglycinemia (HP:0002154)2.95389782
14Febrile seizures (HP:0002373)2.79382777
15Genital tract atresia (HP:0001827)2.72973489
16Progressive cerebellar ataxia (HP:0002073)2.71225544
17Hyperglycinuria (HP:0003108)2.70943369
18Vaginal atresia (HP:0000148)2.70704249
19Ankle clonus (HP:0011448)2.61736604
20Myoglobinuria (HP:0002913)2.61437360
21Abnormality of glycine metabolism (HP:0010895)2.60272846
22Abnormality of serine family amino acid metabolism (HP:0010894)2.60272846
23Papillary thyroid carcinoma (HP:0002895)2.59716293
24Absence seizures (HP:0002121)2.59596363
25Hepatic necrosis (HP:0002605)2.59329888
26Pelvic girdle muscle weakness (HP:0003749)2.57382836
27Renal cortical cysts (HP:0000803)2.57209204
28Delayed CNS myelination (HP:0002188)2.56856894
29Tubulointerstitial nephritis (HP:0001970)2.55412780
30Hepatocellular necrosis (HP:0001404)2.55069806
31Anterior segment dysgenesis (HP:0007700)2.54407516
32Impaired vibration sensation in the lower limbs (HP:0002166)2.49028755
33Megalencephaly (HP:0001355)2.45155615
34Abnormality of the hip-girdle musculature (HP:0001445)2.44546483
35Abnormality of the musculature of the pelvis (HP:0001469)2.44546483
36Insidious onset (HP:0003587)2.42409092
37Termporal pattern (HP:0011008)2.42409092
38Agitation (HP:0000713)2.41112892
39Broad-based gait (HP:0002136)2.40653147
40Pancreatic cysts (HP:0001737)2.40090581
41Limb dystonia (HP:0002451)2.38106933
42Increased muscle lipid content (HP:0009058)2.37744599
43True hermaphroditism (HP:0010459)2.36633360
44Broad foot (HP:0001769)2.36110807
45Pheochromocytoma (HP:0002666)2.35608420
46Depression (HP:0000716)2.35288059
47Poor eye contact (HP:0000817)2.35153600
48Increased intramyocellular lipid droplets (HP:0012240)2.32505046
49Pancreatic fibrosis (HP:0100732)2.29869455
50Poor coordination (HP:0002370)2.28759646
51Poor suck (HP:0002033)2.27027492
52Muscle fiber inclusion bodies (HP:0100299)2.26565572
53Nemaline bodies (HP:0003798)2.26435703
54Rhabdomyolysis (HP:0003201)2.26211289
55Action tremor (HP:0002345)2.24244136
56Hypothermia (HP:0002045)2.24177178
57Generalized tonic-clonic seizures (HP:0002069)2.19234120
58Drooling (HP:0002307)2.17896265
59Excessive salivation (HP:0003781)2.17896265
60Left ventricular hypertrophy (HP:0001712)2.17420966
61Urinary urgency (HP:0000012)2.16668298
62Nephronophthisis (HP:0000090)2.14214485
63Cerebral palsy (HP:0100021)2.12065583
64Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.10420764
65Fetal akinesia sequence (HP:0001989)2.09668390
66EEG with generalized epileptiform discharges (HP:0011198)2.09632808
67Epileptiform EEG discharges (HP:0011182)2.09348361
68Dialeptic seizures (HP:0011146)2.06369369
69Neuroendocrine neoplasm (HP:0100634)2.06308042
70Abnormality of the labia minora (HP:0012880)2.05925426
71Papilledema (HP:0001085)2.02529667
72Hypsarrhythmia (HP:0002521)2.02178831
73Subaortic stenosis (HP:0001682)2.02080540
74Abnormality of the left ventricular outflow tract (HP:0011103)2.02080540
75Mitochondrial inheritance (HP:0001427)2.02001939
76Genetic anticipation (HP:0003743)2.01869287
77Amyotrophic lateral sclerosis (HP:0007354)2.01421816
78Rimmed vacuoles (HP:0003805)2.01237064
79Truncal ataxia (HP:0002078)2.00750599
80Insomnia (HP:0100785)1.97637096
81Abnormal mitochondria in muscle tissue (HP:0008316)1.95844998
82Decreased activity of mitochondrial respiratory chain (HP:0008972)1.95727149
83Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.95727149
84Hypoplasia of the brainstem (HP:0002365)1.95381542
85Aplasia/Hypoplasia of the brainstem (HP:0007362)1.95381542
86Deep palmar crease (HP:0006191)1.94372129
87Increased serum pyruvate (HP:0003542)1.94310961
88Anxiety (HP:0000739)1.94229377
89Distal arthrogryposis (HP:0005684)1.92911222
90Dicarboxylic aciduria (HP:0003215)1.92827489
91Abnormality of dicarboxylic acid metabolism (HP:0010995)1.92827489
92Thyroid-stimulating hormone excess (HP:0002925)1.92667934
93Hyperinsulinemic hypoglycemia (HP:0000825)1.92632672
94Supernumerary spleens (HP:0009799)1.92417516
95Amblyopia (HP:0000646)1.91801067
96Abnormality of the renal medulla (HP:0100957)1.91563705
97Hypoplasia of the thymus (HP:0000778)1.91142513
98Type 2 muscle fiber atrophy (HP:0003554)1.90080199
99Urinary bladder sphincter dysfunction (HP:0002839)1.90032957
100Thyroiditis (HP:0100646)1.88996655
101Muscle hypertrophy of the lower extremities (HP:0008968)1.88033131
102Hemiparesis (HP:0001269)1.88001897
103Thyroid carcinoma (HP:0002890)1.87949622
104Ketoacidosis (HP:0001993)1.87410253
105Ketosis (HP:0001946)1.86483864
106Acute encephalopathy (HP:0006846)1.86050072
107Abnormality of alanine metabolism (HP:0010916)1.84258945
108Hyperalaninemia (HP:0003348)1.84258945
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84258945
110Occipital encephalocele (HP:0002085)1.83004722
111Severe combined immunodeficiency (HP:0004430)1.82901797
112Dyskinesia (HP:0100660)1.82405398
113Abnormality of the renal cortex (HP:0011035)1.82039348
114Unsteady gait (HP:0002317)1.81991619
115Growth hormone excess (HP:0000845)1.81988775
116Decreased testicular size (HP:0008734)1.81856763
117Brushfield spots (HP:0001088)1.81240906
118Bile duct proliferation (HP:0001408)1.81172985
119Abnormal biliary tract physiology (HP:0012439)1.81172985
120Neonatal respiratory distress (HP:0002643)1.80459810
121Sudden death (HP:0001699)1.80322413
122Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79506378
123Degeneration of the lateral corticospinal tracts (HP:0002314)1.79506378
124Sacral dimple (HP:0000960)1.79032580
125Myotonia (HP:0002486)1.78633163
126Pointed chin (HP:0000307)1.78541324
127Impaired social interactions (HP:0000735)1.78428210
128Abnormal social behavior (HP:0012433)1.78428210
129Methylmalonic aciduria (HP:0012120)1.78329064
130Lactic acidosis (HP:0003128)1.77060380
131Calf muscle hypertrophy (HP:0008981)1.76165285
132B lymphocytopenia (HP:0010976)1.74377145
133Acute necrotizing encephalopathy (HP:0006965)1.74069013
134Facial hemangioma (HP:0000329)1.72909655
135Mutism (HP:0002300)1.71281174
136Ventricular fibrillation (HP:0001663)1.70640391
137Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.70377881
138Abnormality of the lower motor neuron (HP:0002366)1.69269838
139Neoplasm of the peripheral nervous system (HP:0100007)1.68640744
140Gaze-evoked nystagmus (HP:0000640)1.67694959
141Lissencephaly (HP:0001339)1.67473334
142Type II lissencephaly (HP:0007260)1.67418524
143Abnormal eating behavior (HP:0100738)1.66521555
144Abnormality of the corticospinal tract (HP:0002492)1.66248015
145Hyperthyroidism (HP:0000836)1.63377417
146Midline defect of the nose (HP:0004122)1.60733004
147Absent speech (HP:0001344)1.60730027
148Abnormality of the calf musculature (HP:0001430)1.60393052
149Exercise-induced myalgia (HP:0003738)1.59298519
150Spastic gait (HP:0002064)1.57753131
151Sporadic (HP:0003745)1.57697433
152Microglossia (HP:0000171)1.56734743
153Neoplasm of the heart (HP:0100544)1.56150866
154Abnormality of chromosome segregation (HP:0002916)1.54881702
155Protruding tongue (HP:0010808)1.54629854
156Supranuclear gaze palsy (HP:0000605)1.53685147
157Anosmia (HP:0000458)1.53387194
158Polyphagia (HP:0002591)1.52658999
159Overgrowth (HP:0001548)1.52229121
160Failure to thrive in infancy (HP:0001531)1.52058828
161Impaired smooth pursuit (HP:0007772)1.52022409
162Esotropia (HP:0000565)1.51954437
163Abnormality of calcium-phosphate metabolism (HP:0100530)1.50924580
164Dysdiadochokinesis (HP:0002075)1.50094552
165Menstrual irregularities (HP:0000858)1.49182291
166Gait imbalance (HP:0002141)1.48981062
167Lower limb muscle weakness (HP:0007340)1.47924773
168Specific learning disability (HP:0001328)1.47844340
169Enlarged penis (HP:0000040)1.47639297
170Limb-girdle muscle weakness (HP:0003325)1.46695623
171Dysmetria (HP:0001310)1.46525061

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.26110562
2MAP3K43.65414016
3BCR3.56669931
4MAP3K93.23256476
5MARK13.18381549
6MAP2K73.07727306
7LATS23.00402955
8NTRK32.99972204
9KSR22.83576686
10BCKDK2.69745840
11KSR12.57017179
12PAK62.28745742
13TAOK32.28110874
14MAP3K62.23729293
15PRKD32.22386679
16EPHA32.19373961
17MINK12.15943221
18MAP2K42.14677096
19MAPK132.01357106
20EPHA41.91792041
21CSNK1A1L1.81397539
22RPS6KA41.78970903
23MAP3K121.69932381
24TRIM281.56387984
25PIK3CA1.54787486
26NTRK21.54166360
27DYRK1B1.53722273
28PHKG11.49303395
29PHKG21.49303395
30MUSK1.30974459
31RAF11.30502177
32CDK191.30302244
33CDC71.29746230
34RET1.25062013
35GRK11.23993277
36WNK41.23819846
37DYRK21.20845832
38NTRK11.19597315
39ACVR1B1.16405906
40LATS11.15344440
41STK381.14216593
42TNIK1.09793592
43BRAF1.09407309
44DMPK1.06775169
45SCYL21.05231131
46PLK21.04396481
47UHMK11.02278845
48ARAF1.01585089
49WNK31.01285881
50NUAK10.98795352
51CDK140.96985722
52CDK180.95986835
53PRKCE0.95065967
54CDK50.94192532
55CDK150.93040290
56STK38L0.92938955
57LMTK20.92706810
58DAPK20.91332967
59CSNK1G20.90089266
60CDK80.90065723
61TAOK10.88996624
62PAK30.86558996
63CAMKK20.84395360
64NEK10.83757072
65CDK11A0.83168735
66ADRBK20.80511912
67PIM20.80322722
68MAPKAPK50.80278688
69TYRO30.79410035
70PINK10.78721225
71CASK0.77819334
72ERBB40.76592983
73MOS0.74437510
74CAMK2A0.74189265
75RIPK10.72767469
76PNCK0.71605483
77TIE10.71421400
78RPS6KA50.70449232
79DYRK1A0.70262365
80INSRR0.69806043
81STK390.68844418
82CAMKK10.67944577
83LIMK10.63656765
84MAP3K20.62016078
85EIF2AK10.61885040
86CSNK1D0.61658521
87TESK10.60916916
88EEF2K0.60199582
89SGK4940.60180619
90SGK2230.60180619
91PRKCG0.60155107
92DYRK30.59871036
93MAP3K130.59285193
94GRK70.58914558
95MAP3K50.58720111
96BRSK10.56599474
97CAMK40.55629043
98SGK20.54782462
99VRK10.54766305
100CHEK20.54560942
101SIK30.53405445
102ERBB30.53366126
103BMPR1B0.52975517
104MAP3K70.52810816
105TESK20.52219338
106PKN20.51871901
107CSNK1G30.51552993
108ZAK0.51051734
109PRKACA0.50075862
110PLK30.48985705
111GRK60.47722942
112FRK0.47075950
113FLT30.46769939
114FER0.46597338
115CDK90.45917401
116NME10.44712944
117STK110.44624515
118PRKAA10.44522017
119SRPK10.43601655
120BRD40.43574935
121MARK20.43452417
122MAP3K110.43304726
123MAP2K10.42310339
124DAPK10.42178782
125CSNK1G10.41651935
126CSNK1A10.41517966
127MAPKAPK30.41031024
128MAPK150.40636509
129CCNB10.39160216
130OXSR10.38455249
131GRK50.37663821
132RPS6KB10.36769252
133ADRBK10.36537309
134PRKACB0.36195543
135CDK30.36144848
136ROCK10.35013329
137MAPK100.34696521
138CAMK10.34319686
139HIPK20.33994421
140OBSCN0.33675003
141TTK0.33077361
142PTK2B0.32725694
143CAMK2D0.32448152
144PRKG10.32286006
145RPS6KA30.32057982
146MAP2K20.27955101
147CAMK2B0.27692881
148CAMK2G0.26238644
149MAPK90.25858563

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.68943534
2Nicotine addiction_Homo sapiens_hsa050332.89698598
3Butanoate metabolism_Homo sapiens_hsa006502.79125187
4Propanoate metabolism_Homo sapiens_hsa006402.73783737
5Synaptic vesicle cycle_Homo sapiens_hsa047212.62162039
6Long-term potentiation_Homo sapiens_hsa047202.40912720
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.26588761
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.10208893
9Oocyte meiosis_Homo sapiens_hsa041142.06612942
10Dopaminergic synapse_Homo sapiens_hsa047282.06212043
11Amphetamine addiction_Homo sapiens_hsa050312.05475467
12Circadian entrainment_Homo sapiens_hsa047132.03050942
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02846578
14Glutamatergic synapse_Homo sapiens_hsa047241.95874374
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.92757000
16Peroxisome_Homo sapiens_hsa041461.92180368
17Insulin secretion_Homo sapiens_hsa049111.91166845
18GABAergic synapse_Homo sapiens_hsa047271.89899058
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.79552227
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.78691496
21Olfactory transduction_Homo sapiens_hsa047401.78453353
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73094505
23Fatty acid elongation_Homo sapiens_hsa000621.72289392
24Long-term depression_Homo sapiens_hsa047301.71631550
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69278024
26Morphine addiction_Homo sapiens_hsa050321.68834227
27Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.66963685
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.66497684
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.66107659
30Regulation of autophagy_Homo sapiens_hsa041401.64663484
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63136691
32Cholinergic synapse_Homo sapiens_hsa047251.60087940
33GnRH signaling pathway_Homo sapiens_hsa049121.57948055
34Fatty acid degradation_Homo sapiens_hsa000711.57791840
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57773412
36beta-Alanine metabolism_Homo sapiens_hsa004101.55761534
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.51863531
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51593157
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51034771
40Oxytocin signaling pathway_Homo sapiens_hsa049211.48214467
41Serotonergic synapse_Homo sapiens_hsa047261.47037056
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.44114098
43Glioma_Homo sapiens_hsa052141.41774931
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.40782308
45Cocaine addiction_Homo sapiens_hsa050301.40738564
46Taste transduction_Homo sapiens_hsa047421.40622568
47Gap junction_Homo sapiens_hsa045401.39621304
48Cardiac muscle contraction_Homo sapiens_hsa042601.37095386
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.36443299
50Circadian rhythm_Homo sapiens_hsa047101.36294204
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.34848377
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.29732686
53Salivary secretion_Homo sapiens_hsa049701.29558249
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.27675671
55Chemical carcinogenesis_Homo sapiens_hsa052041.27505803
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26951386
57Estrogen signaling pathway_Homo sapiens_hsa049151.25267962
58Protein export_Homo sapiens_hsa030601.23258915
59Axon guidance_Homo sapiens_hsa043601.22646643
60Histidine metabolism_Homo sapiens_hsa003401.22188185
61Steroid hormone biosynthesis_Homo sapiens_hsa001401.21735927
62Retinol metabolism_Homo sapiens_hsa008301.21725374
63Arginine and proline metabolism_Homo sapiens_hsa003301.20912666
64ErbB signaling pathway_Homo sapiens_hsa040121.20499108
65Colorectal cancer_Homo sapiens_hsa052101.20075860
66Fatty acid metabolism_Homo sapiens_hsa012121.19930615
67Cell cycle_Homo sapiens_hsa041101.19789367
68Pyruvate metabolism_Homo sapiens_hsa006201.18822126
69Linoleic acid metabolism_Homo sapiens_hsa005911.18462792
70Gastric acid secretion_Homo sapiens_hsa049711.17783441
71Melanogenesis_Homo sapiens_hsa049161.16959648
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14448208
73Renin secretion_Homo sapiens_hsa049241.14411705
74Phenylalanine metabolism_Homo sapiens_hsa003601.12426567
75Calcium signaling pathway_Homo sapiens_hsa040201.11862696
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11409237
77Type II diabetes mellitus_Homo sapiens_hsa049301.11160191
78cAMP signaling pathway_Homo sapiens_hsa040241.09755289
79Arginine biosynthesis_Homo sapiens_hsa002201.08789890
80Alcoholism_Homo sapiens_hsa050341.08273835
81Carbon metabolism_Homo sapiens_hsa012001.08237600
82Caffeine metabolism_Homo sapiens_hsa002321.06496198
83Wnt signaling pathway_Homo sapiens_hsa043101.02981734
84Steroid biosynthesis_Homo sapiens_hsa001001.02875402
85mTOR signaling pathway_Homo sapiens_hsa041501.02590951
86Endometrial cancer_Homo sapiens_hsa052131.02165639
87Glucagon signaling pathway_Homo sapiens_hsa049221.01344067
88Renal cell carcinoma_Homo sapiens_hsa052111.00550959
89Tryptophan metabolism_Homo sapiens_hsa003800.99124153
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98647814
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98219471
92Arachidonic acid metabolism_Homo sapiens_hsa005900.96311624
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95924050
94Dilated cardiomyopathy_Homo sapiens_hsa054140.94429482
95Base excision repair_Homo sapiens_hsa034100.94341070
96Tyrosine metabolism_Homo sapiens_hsa003500.93338773
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92747684
98Fat digestion and absorption_Homo sapiens_hsa049750.92610005
99Dorso-ventral axis formation_Homo sapiens_hsa043200.91606288
100mRNA surveillance pathway_Homo sapiens_hsa030150.90604965
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89913165
102Choline metabolism in cancer_Homo sapiens_hsa052310.89779380
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89601959
104Selenocompound metabolism_Homo sapiens_hsa004500.88176702
105VEGF signaling pathway_Homo sapiens_hsa043700.88110827
106Insulin signaling pathway_Homo sapiens_hsa049100.86988029
107Non-small cell lung cancer_Homo sapiens_hsa052230.84578941
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83295000
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82270453
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81892222
111Pancreatic cancer_Homo sapiens_hsa052120.81702897
112Ovarian steroidogenesis_Homo sapiens_hsa049130.80549614
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80527522
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76927380
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.76029048
116Biosynthesis of amino acids_Homo sapiens_hsa012300.75973311
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.75754656
118Huntingtons disease_Homo sapiens_hsa050160.75428783
119Ether lipid metabolism_Homo sapiens_hsa005650.75077964
120Metabolic pathways_Homo sapiens_hsa011000.74557899
121Vibrio cholerae infection_Homo sapiens_hsa051100.74164614
122Hedgehog signaling pathway_Homo sapiens_hsa043400.74004148
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73367155
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73216240
125MAPK signaling pathway_Homo sapiens_hsa040100.70745600
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.69976469
127Hippo signaling pathway_Homo sapiens_hsa043900.69882368
128Bladder cancer_Homo sapiens_hsa052190.69648133
129Parkinsons disease_Homo sapiens_hsa050120.69585612
130Thyroid cancer_Homo sapiens_hsa052160.68091373
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.68077747
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.67770966
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67662587
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67043143
135Starch and sucrose metabolism_Homo sapiens_hsa005000.66603093
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66509049
137Alzheimers disease_Homo sapiens_hsa050100.64089627
138Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63879479
139Melanoma_Homo sapiens_hsa052180.63468275
140Non-homologous end-joining_Homo sapiens_hsa034500.63282831
141Prolactin signaling pathway_Homo sapiens_hsa049170.62282308
142RNA degradation_Homo sapiens_hsa030180.62130781
143AMPK signaling pathway_Homo sapiens_hsa041520.61694755
144Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61475301
145Nitrogen metabolism_Homo sapiens_hsa009100.58113213
146Ras signaling pathway_Homo sapiens_hsa040140.57862334
147Oxidative phosphorylation_Homo sapiens_hsa001900.57300491
148Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56485807
149PPAR signaling pathway_Homo sapiens_hsa033200.55593367
150Collecting duct acid secretion_Homo sapiens_hsa049660.53970381
151Thyroid hormone synthesis_Homo sapiens_hsa049180.53271938
152Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51127071
153Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49849676
154Basal transcription factors_Homo sapiens_hsa030220.48960618
155Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48541961
156Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48528766
157Pancreatic secretion_Homo sapiens_hsa049720.47742935
158Phototransduction_Homo sapiens_hsa047440.47363711
159Cyanoamino acid metabolism_Homo sapiens_hsa004600.47342710
160RNA transport_Homo sapiens_hsa030130.47294906
161Renin-angiotensin system_Homo sapiens_hsa046140.39621285
162Purine metabolism_Homo sapiens_hsa002300.39590337
163RNA polymerase_Homo sapiens_hsa030200.38991793
164Fanconi anemia pathway_Homo sapiens_hsa034600.38260334
165Folate biosynthesis_Homo sapiens_hsa007900.38236164

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