KLHDC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.99441553
2negative T cell selection (GO:0043383)4.95209902
3negative thymic T cell selection (GO:0045060)4.94540525
4positive regulation of gamma-delta T cell activation (GO:0046645)4.89230924
5positive thymic T cell selection (GO:0045059)4.85347545
6thymic T cell selection (GO:0045061)4.79504976
7regulation of gamma-delta T cell differentiation (GO:0045586)4.41825244
8DNA strand elongation involved in DNA replication (GO:0006271)4.34328907
9positive T cell selection (GO:0043368)4.30943143
10formation of translation preinitiation complex (GO:0001731)4.26481115
11DNA unwinding involved in DNA replication (GO:0006268)4.18449745
12T cell selection (GO:0045058)4.14660596
13DNA strand elongation (GO:0022616)4.10532355
14DNA replication initiation (GO:0006270)4.08353221
15telomere maintenance via semi-conservative replication (GO:0032201)4.06598426
16regulation of gamma-delta T cell activation (GO:0046643)4.01249193
17histone H3-K4 trimethylation (GO:0080182)3.88589333
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.87962320
19negative regulation of cell killing (GO:0031342)3.87962320
20nucleobase biosynthetic process (GO:0046112)3.85021889
21maturation of SSU-rRNA (GO:0030490)3.82463814
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.74029758
23folic acid-containing compound biosynthetic process (GO:0009396)3.71475701
24positive regulation of granulocyte differentiation (GO:0030854)3.71137311
25positive regulation of CREB transcription factor activity (GO:0032793)3.67752190
26ribosome assembly (GO:0042255)3.66883780
27telomere maintenance via recombination (GO:0000722)3.66308447
28protein localization to kinetochore (GO:0034501)3.62979516
29leukocyte aggregation (GO:0070486)3.49927410
30IMP biosynthetic process (GO:0006188)3.47388774
31mitotic nuclear envelope disassembly (GO:0007077)3.46983996
32ribosomal small subunit assembly (GO:0000028)3.46001042
33DNA deamination (GO:0045006)3.44727293
34ribosome biogenesis (GO:0042254)3.43977638
35DNA replication checkpoint (GO:0000076)3.41967194
36mitotic recombination (GO:0006312)3.38484508
37activated T cell proliferation (GO:0050798)3.38061562
38histone H3-K4 methylation (GO:0051568)3.36317880
39purine nucleobase biosynthetic process (GO:0009113)3.36202918
40antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.36039710
41histone H3-K36 demethylation (GO:0070544)3.34527272
42tolerance induction (GO:0002507)3.29885172
43mannose metabolic process (GO:0006013)3.28760311
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.26638405
45cellular response to interleukin-15 (GO:0071350)3.26503219
46response to interleukin-15 (GO:0070672)3.25885744
47regulation of histone H3-K27 methylation (GO:0061085)3.25190136
48membrane disassembly (GO:0030397)3.23354147
49nuclear envelope disassembly (GO:0051081)3.23354147
50regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.22779326
51antigen processing and presentation of endogenous antigen (GO:0019883)3.21706665
52B cell receptor signaling pathway (GO:0050853)3.21449691
53natural killer cell differentiation (GO:0001779)3.18924208
54DNA replication-dependent nucleosome assembly (GO:0006335)3.18042227
55DNA replication-dependent nucleosome organization (GO:0034723)3.18042227
56positive regulation of histone deacetylation (GO:0031065)3.17460128
57mitotic metaphase plate congression (GO:0007080)3.16650795
58positive regulation by host of viral transcription (GO:0043923)3.16499620
59telomere maintenance via telomere lengthening (GO:0010833)3.15038015
60ribonucleoprotein complex biogenesis (GO:0022613)3.14931987
61regulation of B cell receptor signaling pathway (GO:0050855)3.14580350
62IMP metabolic process (GO:0046040)3.14073350
63histone H3-K9 modification (GO:0061647)3.13529931
64Peyers patch development (GO:0048541)3.13300218
65mucosal-associated lymphoid tissue development (GO:0048537)3.13300218
66intracellular estrogen receptor signaling pathway (GO:0030520)3.12739433
67regulation of histone H3-K4 methylation (GO:0051569)3.12452044
68viral transcription (GO:0019083)3.11298766
69ribosomal large subunit biogenesis (GO:0042273)3.11181521
70spliceosomal tri-snRNP complex assembly (GO:0000244)3.09610906
71translational termination (GO:0006415)3.08779782
72histone H3-K9 methylation (GO:0051567)3.06221014
73translational initiation (GO:0006413)3.03830817
74regulation of granulocyte differentiation (GO:0030852)3.03155765
75nuclear pore organization (GO:0006999)3.01842725
76modulation by virus of host process (GO:0019054)3.00994563
77protein localization to chromosome, centromeric region (GO:0071459)3.00138152
78CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.99781495
79rRNA processing (GO:0006364)2.99686599
80nucleotide-excision repair, DNA gap filling (GO:0006297)2.95831741
81regulation of nuclear cell cycle DNA replication (GO:0033262)2.94223345
82translational elongation (GO:0006414)2.92637592
83cellular response to virus (GO:0098586)2.92581034
84negative regulation of histone methylation (GO:0031061)2.92361307
85antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.92345796
86negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.91843342
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90491636
88B cell mediated immunity (GO:0019724)2.89797703
89rRNA metabolic process (GO:0016072)2.87916500
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.87484160
91spliceosomal snRNP assembly (GO:0000387)2.87381521
92immunoglobulin mediated immune response (GO:0016064)2.85152360
93tRNA methylation (GO:0030488)2.84921630
94anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.84534992
95regulation of translational termination (GO:0006449)2.84152477
96peptidyl-lysine methylation (GO:0018022)2.81582097
97somatic diversification of immune receptors via somatic mutation (GO:0002566)2.79920421
98somatic hypermutation of immunoglobulin genes (GO:0016446)2.79920421
99regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.79901165
100positive regulation of protein deacetylation (GO:0090312)2.79726352
101positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.78904696
102antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.75757584
103ribosomal small subunit biogenesis (GO:0042274)2.73103318
104peptidyl-lysine trimethylation (GO:0018023)2.72891616
105histone H3 deacetylation (GO:0070932)2.72888446
106DNA duplex unwinding (GO:0032508)2.72817410
107cellular response to interleukin-4 (GO:0071353)2.72236204
108histone lysine methylation (GO:0034968)2.72090770
109nucleobase-containing small molecule interconversion (GO:0015949)2.71986574
110DNA geometric change (GO:0032392)2.71686642
111histone H4 deacetylation (GO:0070933)2.71197130
112snRNA metabolic process (GO:0016073)2.71168904
113positive regulation of gene expression, epigenetic (GO:0045815)2.71131918
114nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.71072399
115positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.70452928
116cell cycle G1/S phase transition (GO:0044843)2.69449425
117G1/S transition of mitotic cell cycle (GO:0000082)2.69449425
118tRNA modification (GO:0006400)2.67625502
119regulation of protein heterodimerization activity (GO:0043497)2.67289579
120chromatin silencing (GO:0006342)2.66922685
121folic acid metabolic process (GO:0046655)2.65860263
122histone H4-K16 acetylation (GO:0043984)2.63742289
123histone methylation (GO:0016571)2.63548394
124base-excision repair (GO:0006284)2.63332459
125metaphase plate congression (GO:0051310)2.62693133
126nuclear pore complex assembly (GO:0051292)2.62454580
127regulation of histone methylation (GO:0031060)2.62259295
128DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.61746989
129negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.60717381
130negative regulation of ligase activity (GO:0051352)2.60717381
131negative regulation of cAMP-mediated signaling (GO:0043951)2.60371946
132signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.59922489
133intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.59922489
134DNA methylation (GO:0006306)2.59887099
135DNA alkylation (GO:0006305)2.59887099
136regulation of type I interferon-mediated signaling pathway (GO:0060338)2.58441631
137negative regulation of gene expression, epigenetic (GO:0045814)2.58284356
138signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.57968841
139signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.57968841
140signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.57968841
141negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.57670899
142regulation of B cell differentiation (GO:0045577)2.57663195
143nuclear envelope organization (GO:0006998)2.56977393
144signal transduction involved in DNA damage checkpoint (GO:0072422)2.56542312
145signal transduction involved in DNA integrity checkpoint (GO:0072401)2.56542312
146Arp2/3 complex-mediated actin nucleation (GO:0034314)2.56540364
147interferon-gamma production (GO:0032609)2.56460449
148negative regulation of erythrocyte differentiation (GO:0045647)2.54681218
149SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.54273115
150establishment of chromosome localization (GO:0051303)2.54252923
151viral mRNA export from host cell nucleus (GO:0046784)2.54193583
152mitotic sister chromatid segregation (GO:0000070)2.53640691
153regulation of gene silencing by RNA (GO:0060966)2.52609148
154regulation of posttranscriptional gene silencing (GO:0060147)2.52609148
155regulation of gene silencing by miRNA (GO:0060964)2.52609148
156negative regulation of T cell mediated immunity (GO:0002710)2.52332184
157pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.51843004
158signal transduction involved in cell cycle checkpoint (GO:0072395)2.51820865
159ncRNA 3-end processing (GO:0043628)2.51730092
160snRNA processing (GO:0016180)2.50781270
161regulation of double-strand break repair via homologous recombination (GO:0010569)2.50464749
162antigen receptor-mediated signaling pathway (GO:0050851)2.50022755
163negative regulation of lymphocyte mediated immunity (GO:0002707)2.49620438
164NIK/NF-kappaB signaling (GO:0038061)2.49081082
165chromatin remodeling at centromere (GO:0031055)2.47881915
166CENP-A containing nucleosome assembly (GO:0034080)2.47487663
167pseudouridine synthesis (GO:0001522)2.47233330
168viral life cycle (GO:0019058)2.46845553
169transcription-coupled nucleotide-excision repair (GO:0006283)2.46446194
170regulation of alpha-beta T cell proliferation (GO:0046640)2.46143053
171positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.46019357
172negative regulation of histone acetylation (GO:0035067)2.45207353
173regulation of translational fidelity (GO:0006450)2.44967281
174telomere organization (GO:0032200)2.44944583
175protein targeting to ER (GO:0045047)2.44866090
176regulation of spindle organization (GO:0090224)2.44123290
177DNA topological change (GO:0006265)2.43905887
178telomere maintenance (GO:0000723)2.43867859
179regulation of translation in response to stress (GO:0043555)2.43839065
180cotranslational protein targeting to membrane (GO:0006613)2.43722513
181cellular protein complex disassembly (GO:0043624)2.43708548
182regulation of histone deacetylation (GO:0031063)2.42250112
183negative regulation of innate immune response (GO:0045824)2.42018338
184negative regulation of mRNA processing (GO:0050686)2.41537301
185meiotic chromosome segregation (GO:0045132)2.40726596
186GDP-mannose metabolic process (GO:0019673)2.40630716
187mast cell degranulation (GO:0043303)2.39935027
188mast cell activation involved in immune response (GO:0002279)2.39935027
189regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.39784172
190regulation of natural killer cell mediated immunity (GO:0002715)2.39784172
191chromatin assembly (GO:0031497)2.39748197

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.59106907
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.74689682
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.66583406
4* FOXM1_23109430_ChIP-Seq_U2OS_Human3.19564399
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.76252401
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.75258467
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69983526
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.50301784
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43512840
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.43249303
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.40641880
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.35868455
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32609022
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.30033094
15* GABP_17652178_ChIP-ChIP_JURKAT_Human2.29207885
16P68_20966046_ChIP-Seq_HELA_Human2.25029908
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.23785720
18LXR_22292898_ChIP-Seq_THP-1_Human2.22681949
19MAF_26560356_Chip-Seq_TH2_Human2.22167341
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21296990
21* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.17294226
22* MYC_22102868_ChIP-Seq_BL_Human2.13800079
23* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.10187964
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.05655709
25XRN2_22483619_ChIP-Seq_HELA_Human2.05568726
26CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.04226135
27KDM2B_26808549_Chip-Seq_DND41_Human2.02379164
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00186410
29* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94770664
30TCF7_22412390_ChIP-Seq_EML_Mouse1.94479099
31* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.92345283
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.90584423
33VDR_23849224_ChIP-Seq_CD4+_Human1.89974959
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78411767
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.78247634
36BCOR_27268052_Chip-Seq_Bcells_Human1.78086923
37BCL6_27268052_Chip-Seq_Bcells_Human1.76911099
38* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75994616
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74541012
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73212404
41DCP1A_22483619_ChIP-Seq_HELA_Human1.70168271
42ELF1_20517297_ChIP-Seq_JURKAT_Human1.68923428
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67177167
44SMC4_20622854_ChIP-Seq_HELA_Human1.64834114
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64648066
46* GABP_19822575_ChIP-Seq_HepG2_Human1.64326255
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63880493
48VDR_21846776_ChIP-Seq_THP-1_Human1.62713277
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62193987
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.60362933
51FOXP3_21729870_ChIP-Seq_TREG_Human1.60309333
52E2F1_20622854_ChIP-Seq_HELA_Human1.59750135
53* PHF8_20622854_ChIP-Seq_HELA_Human1.58596444
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.58340667
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55801925
56SCL_19346495_ChIP-Seq_HPC-7_Human1.53559577
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52663996
58* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52234461
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52076357
60SA1_27219007_Chip-Seq_ERYTHROID_Human1.51024185
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.50730191
62CIITA_25753668_ChIP-Seq_RAJI_Human1.49304513
63* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49068783
64TTF2_22483619_ChIP-Seq_HELA_Human1.47615434
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47260694
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44820725
67CTCF_27219007_Chip-Seq_ERYTHROID_Human1.44749275
68SPI1_23547873_ChIP-Seq_NB4_Human1.43705274
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43521287
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.43205000
71* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43031593
72RACK7_27058665_Chip-Seq_MCF-7_Human1.41560218
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.40671510
74AR_21909140_ChIP-Seq_LNCAP_Human1.40402677
75* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38990618
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38966685
77IRF8_22096565_ChIP-ChIP_GC-B_Human1.38898422
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37256257
79TFEB_21752829_ChIP-Seq_HELA_Human1.37222199
80MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35851252
81KDM5A_27292631_Chip-Seq_BREAST_Human1.35842628
82SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.34610662
83E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33929819
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.33346218
85ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31889705
86KDM2B_26808549_Chip-Seq_JURKAT_Human1.31022556
87* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30889569
88SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28701408
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.27335768
90HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27334491
91ELK1_19687146_ChIP-ChIP_HELA_Human1.27153365
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26867981
93FOXP1_21924763_ChIP-Seq_HESCs_Human1.26429329
94PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26403810
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26284887
96P300_27268052_Chip-Seq_Bcells_Human1.23424651
97NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23337707
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22301958
99YY1_22570637_ChIP-Seq_MALME-3M_Human1.22094582
100* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22048142
101NOTCH1_21737748_ChIP-Seq_TLL_Human1.22036310
102RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.21049843
103PKCTHETA_26484144_Chip-Seq_BREAST_Human1.20830159
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20721510
105IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20703843
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20406354
107MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.20240401
108ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19479770
109CTCF_21964334_ChIP-Seq_BJAB-B_Human1.19316858
110NCOR1_26117541_ChIP-Seq_K562_Human1.18950561
111HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18848865
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17548568
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17413094
114* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17258892
115CREB1_26743006_Chip-Seq_LNCaP_Human1.17227894
116* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.15802960
117RARB_24833708_ChIP-Seq_LIVER_Mouse1.15723841
118CTCF_26484167_Chip-Seq_Bcells_Mouse1.15604929
119SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15497771
120MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14786606
121SRF_21415370_ChIP-Seq_HL-1_Mouse1.13934421
122DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13853419
123ERA_21632823_ChIP-Seq_H3396_Human1.12856681
124RARA_24833708_ChIP-Seq_LIVER_Mouse1.12663283
125CTCF_21964334_Chip-Seq_Bcells_Human1.12155543
126CTCF_27219007_Chip-Seq_Bcells_Human1.12054543
127SA1_27219007_Chip-Seq_Bcells_Human1.11792311
128CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11408606
129ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11295729
130BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10550122
131RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09579314
132YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09113898
133KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08937747
134* OCT4_19829295_ChIP-Seq_ESCs_Human1.08773368
135TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08143092
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08110159
137RUNX_20019798_ChIP-Seq_JUKART_Human1.07009028
138STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04293705
139MAF_26560356_Chip-Seq_TH1_Human1.02644876
140NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02221753
141RUNX1_22412390_ChIP-Seq_EML_Mouse1.02144924
142* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02094226
143GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99848920
144UTX_26944678_Chip-Seq_JUKART_Human0.99084995
145* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98551428
146BP1_19119308_ChIP-ChIP_Hs578T_Human0.93837708
147MYB_26560356_Chip-Seq_TH1_Human0.93537263
148* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92863881
149* MYB_26560356_Chip-Seq_TH2_Human0.92213167
150HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91868967
151POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91501898
152VDR_24763502_ChIP-Seq_THP-1_Human0.90849178
153* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90164799
154TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90019338
155BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89186880
156OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89110055

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.42378595
2MP0003111_abnormal_nucleus_morphology3.39070006
3MP0004957_abnormal_blastocyst_morpholog3.34179872
4MP0010094_abnormal_chromosome_stability3.29668581
5MP0003077_abnormal_cell_cycle3.10855286
6MP0008057_abnormal_DNA_replication2.81464707
7MP0001835_abnormal_antigen_presentation2.75352987
8MP0010352_gastrointestinal_tract_polyps2.70219526
9MP0003436_decreased_susceptibility_to2.68989911
10MP0008058_abnormal_DNA_repair2.26035318
11MP0004381_abnormal_hair_follicle2.14853158
12MP0002396_abnormal_hematopoietic_system2.11131274
13MP0005451_abnormal_body_composition2.01521948
14MP0010307_abnormal_tumor_latency1.99560336
15MP0003303_peritoneal_inflammation1.96785489
16MP0009333_abnormal_splenocyte_physiolog1.95805211
17MP0009785_altered_susceptibility_to1.94232955
18MP0008007_abnormal_cellular_replicative1.88132271
19MP0008932_abnormal_embryonic_tissue1.87462816
20MP0002452_abnormal_antigen_presenting1.87451884
21MP0000350_abnormal_cell_proliferation1.86977251
22MP0000490_abnormal_crypts_of1.86831829
23MP0005000_abnormal_immune_tolerance1.86706259
24MP0005076_abnormal_cell_differentiation1.86311848
25MP0000685_abnormal_immune_system1.86287778
26MP0005025_abnormal_response_to1.83745764
27MP0001730_embryonic_growth_arrest1.83599998
28MP0001800_abnormal_humoral_immune1.80172090
29MP0002419_abnormal_innate_immunity1.77587118
30MP0001853_heart_inflammation1.74181192
31MP0003806_abnormal_nucleotide_metabolis1.74080267
32MP0002405_respiratory_system_inflammati1.73849780
33MP0002723_abnormal_immune_serum1.72480630
34MP0002148_abnormal_hypersensitivity_rea1.70757719
35MP0002398_abnormal_bone_marrow1.69791250
36MP0001348_abnormal_lacrimal_gland1.68107450
37MP0002420_abnormal_adaptive_immunity1.67259733
38MP0001819_abnormal_immune_cell1.67249684
39MP0000858_altered_metastatic_potential1.60145790
40MP0000689_abnormal_spleen_morphology1.56445492
41MP0002019_abnormal_tumor_incidence1.54135915
42MP0002722_abnormal_immune_system1.53800476
43MP0003763_abnormal_thymus_physiology1.53229747
44MP0008995_early_reproductive_senescence1.52225044
45MP0005671_abnormal_response_to1.52065829
46MP0001545_abnormal_hematopoietic_system1.50706062
47MP0005397_hematopoietic_system_phenotyp1.50706062
48MP0003866_abnormal_defecation1.48570291
49MP0005310_abnormal_salivary_gland1.48204671
50MP0000716_abnormal_immune_system1.48048821
51MP0009840_abnormal_foam_cell1.45881863
52MP0008961_abnormal_basal_metabolism1.44470152
53MP0005075_abnormal_melanosome_morpholog1.43058334
54MP0002429_abnormal_blood_cell1.41920793
55MP0009278_abnormal_bone_marrow1.41681896
56MP0001790_abnormal_immune_system1.40627585
57MP0005387_immune_system_phenotype1.40627585
58MP0003787_abnormal_imprinting1.37798360
59MP0000313_abnormal_cell_death1.36553356
60MP0003705_abnormal_hypodermis_morpholog1.36110489
61MP0003448_altered_tumor_morphology1.34119945
62MP0002163_abnormal_gland_morphology1.33670368
63MP0003786_premature_aging1.33432133
64MP0005058_abnormal_lysosome_morphology1.31247941
65MP0003123_paternal_imprinting1.29392121
66MP0004808_abnormal_hematopoietic_stem1.28939908
67MP0003172_abnormal_lysosome_physiology1.28914483
68MP0000703_abnormal_thymus_morphology1.27574209
69MP0003191_abnormal_cellular_cholesterol1.26413520
70MP0005464_abnormal_platelet_physiology1.25353037
71MP0004185_abnormal_adipocyte_glucose1.24230289
72MP0001845_abnormal_inflammatory_respons1.23487018
73MP0001986_abnormal_taste_sensitivity1.23147161
74MP0004947_skin_inflammation1.22325574
75MP0002080_prenatal_lethality1.22243915
76MP0002653_abnormal_ependyma_morphology1.20382575
77MP0001697_abnormal_embryo_size1.19571742
78MP0003186_abnormal_redox_activity1.19217112
79MP0005377_hearing/vestibular/ear_phenot1.19210428
80MP0003878_abnormal_ear_physiology1.19210428
81MP0006082_CNS_inflammation1.16956730
82MP0001672_abnormal_embryogenesis/_devel1.16828128
83MP0005380_embryogenesis_phenotype1.16828128
84MP0004510_myositis1.16765419
85MP0010155_abnormal_intestine_physiology1.14350582
86MP0003566_abnormal_cell_adhesion1.12052505
87MP0005083_abnormal_biliary_tract1.08561657
88MP0001873_stomach_inflammation1.08561116
89MP0003984_embryonic_growth_retardation1.07433348
90MP0000358_abnormal_cell_content/1.07194264
91MP0008260_abnormal_autophagy1.05396410
92MP0002088_abnormal_embryonic_growth/wei1.03938471
93MP0005174_abnormal_tail_pigmentation1.03783154
94MP0005023_abnormal_wound_healing1.02949191
95MP0000371_diluted_coat_color1.02461095
96MP0001533_abnormal_skeleton_physiology1.01732670
97MP0004197_abnormal_fetal_growth/weight/0.98900809
98MP0002086_abnormal_extraembryonic_tissu0.98608845
99MP0000470_abnormal_stomach_morphology0.98040340
100MP0006292_abnormal_olfactory_placode0.97566308
101MP0005645_abnormal_hypothalamus_physiol0.95957324
102MP0002970_abnormal_white_adipose0.94602793
103MP0002009_preneoplasia0.94370107
104MP0003724_increased_susceptibility_to0.94166808
105MP0002138_abnormal_hepatobiliary_system0.93543220
106MP0008469_abnormal_protein_level0.92853965
107MP0002132_abnormal_respiratory_system0.91436003
108MP0000015_abnormal_ear_pigmentation0.90777099
109MP0006035_abnormal_mitochondrial_morpho0.89601684
110MP0000465_gastrointestinal_hemorrhage0.88746131
111MP0002085_abnormal_embryonic_tissue0.88536839
112MP0002249_abnormal_larynx_morphology0.87643062
113MP0003453_abnormal_keratinocyte_physiol0.84850289
114MP0001663_abnormal_digestive_system0.84183772
115MP0005621_abnormal_cell_physiology0.83789004
116MP0002693_abnormal_pancreas_physiology0.82244281
117MP0003943_abnormal_hepatobiliary_system0.82126035
118MP0002084_abnormal_developmental_patter0.80394883
119MP0000343_altered_response_to0.80034971
120MP0005384_cellular_phenotype0.78547948
121MP0002254_reproductive_system_inflammat0.77670093
122MP0003718_maternal_effect0.76837259
123MP0004130_abnormal_muscle_cell0.76484612
124MP0000750_abnormal_muscle_regeneration0.76441246
125MP0002006_tumorigenesis0.76106106
126MP0008877_abnormal_DNA_methylation0.75983554
127MP0001929_abnormal_gametogenesis0.72588906
128MP0002928_abnormal_bile_duct0.72443143
129MP0003698_abnormal_male_reproductive0.72162708
130MP0002210_abnormal_sex_determination0.70931912
131MP0001293_anophthalmia0.70732690
132MP0002822_catalepsy0.69335166
133MP0005670_abnormal_white_adipose0.68517397
134MP0001346_abnormal_lacrimal_gland0.68371865
135MP0000678_abnormal_parathyroid_gland0.68349212
136MP0005266_abnormal_metabolism0.67875314
137MP0003136_yellow_coat_color0.67001087
138MP0000598_abnormal_liver_morphology0.65793062
139MP0003567_abnormal_fetal_cardiomyocyte0.65116039
140MP0002166_altered_tumor_susceptibility0.64924771
141MP0005410_abnormal_fertilization0.63385524
142MP0000477_abnormal_intestine_morphology0.63330763
143MP0005220_abnormal_exocrine_pancreas0.62734610
144MP0002933_joint_inflammation0.62527173
145MP0005379_endocrine/exocrine_gland_phen0.62110221
146MP0000367_abnormal_coat/_hair0.61741053
147MP0002083_premature_death0.60339409

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.45421220
2Recurrent abscess formation (HP:0002722)4.80203694
3Panhypogammaglobulinemia (HP:0003139)4.59748786
4Recurrent bacterial skin infections (HP:0005406)4.35672383
5Recurrent gram-negative bacterial infections (HP:0005420)4.08971327
6Agnosia (HP:0010524)3.81937317
7Abnormal delayed hypersensitivity skin test (HP:0002963)3.76516798
8Agammaglobulinemia (HP:0004432)3.70202367
9Abnormality of macrophages (HP:0004311)3.68152267
10Abnormality of the fingertips (HP:0001211)3.53315837
11Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.50949478
12Birth length less than 3rd percentile (HP:0003561)3.50403174
13Reticulocytopenia (HP:0001896)3.43380195
14Degeneration of anterior horn cells (HP:0002398)3.37115268
15Abnormality of the anterior horn cell (HP:0006802)3.37115268
16Colitis (HP:0002583)3.33181191
17Mediastinal lymphadenopathy (HP:0100721)3.29230481
18Abnormality of cells of the erythroid lineage (HP:0012130)3.16972212
19IgM deficiency (HP:0002850)3.16021749
20Selective tooth agenesis (HP:0001592)3.12892737
21Abnormal number of erythroid precursors (HP:0012131)3.10182537
22Recurrent fungal infections (HP:0002841)3.09215472
23Multiple enchondromatosis (HP:0005701)3.03397594
24Obstructive lung disease (HP:0006536)3.00882852
25Chronic obstructive pulmonary disease (HP:0006510)3.00882852
26Rough bone trabeculation (HP:0100670)3.00295229
27Oral leukoplakia (HP:0002745)2.93173662
28Gastrointestinal inflammation (HP:0004386)2.75083193
29Hyperacusis (HP:0010780)2.72931980
30Severe combined immunodeficiency (HP:0004430)2.71244695
31Spinal muscular atrophy (HP:0007269)2.70691490
32Encephalitis (HP:0002383)2.68886871
33Breast hypoplasia (HP:0003187)2.68447978
34Carpal bone hypoplasia (HP:0001498)2.67247642
35Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.66974507
36Cellulitis (HP:0100658)2.66556675
37Meningitis (HP:0001287)2.63065968
38Squamous cell carcinoma (HP:0002860)2.61055580
39Elevated erythrocyte sedimentation rate (HP:0003565)2.57110774
40Recurrent viral infections (HP:0004429)2.54850145
41Stomatitis (HP:0010280)2.53780964
42Inflammation of the large intestine (HP:0002037)2.53770104
43Abnormality of DNA repair (HP:0003254)2.52872089
44Recurrent skin infections (HP:0001581)2.50948656
45Attenuation of retinal blood vessels (HP:0007843)2.46413466
46Pustule (HP:0200039)2.45983385
47Chromsome breakage (HP:0040012)2.45775098
48Impulsivity (HP:0100710)2.43865926
49Viral hepatitis (HP:0006562)2.43186886
50Gingivitis (HP:0000230)2.42964512
51Increased IgE level (HP:0003212)2.40680750
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.39991021
53Hypoplasia of the pons (HP:0012110)2.39021880
54Thrombocytosis (HP:0001894)2.38949048
55Lymphoma (HP:0002665)2.38556739
56Patellar aplasia (HP:0006443)2.38222409
57Aplastic anemia (HP:0001915)2.37885389
58Progressive muscle weakness (HP:0003323)2.36941758
59Premature graying of hair (HP:0002216)2.36591684
60Pallor (HP:0000980)2.34366893
61Cellular immunodeficiency (HP:0005374)2.34005269
62Tracheoesophageal fistula (HP:0002575)2.32134360
63Trismus (HP:0000211)2.31549071
64Clumsiness (HP:0002312)2.29801059
65Ependymoma (HP:0002888)2.29581214
66Autoimmune thrombocytopenia (HP:0001973)2.29346160
67Bone marrow hypocellularity (HP:0005528)2.29008056
68Increased neuronal autofluorescent lipopigment (HP:0002074)2.27371658
69Hypochromic anemia (HP:0001931)2.27101161
70Atrophy/Degeneration involving motor neurons (HP:0007373)2.25725255
71Macrocytic anemia (HP:0001972)2.25221239
72Optic nerve coloboma (HP:0000588)2.25204410
73Aplasia/Hypoplasia of the patella (HP:0006498)2.24103611
74Gastrointestinal infarctions (HP:0005244)2.21655143
75Microvesicular hepatic steatosis (HP:0001414)2.21241885
76Testicular atrophy (HP:0000029)2.16926120
77Acute lymphatic leukemia (HP:0006721)2.16613845
78Absent thumb (HP:0009777)2.16575433
79Abnormal trabecular bone morphology (HP:0100671)2.15047048
80Abnormality of the pons (HP:0007361)2.14046115
81Colon cancer (HP:0003003)2.12833395
82Rib fusion (HP:0000902)2.12756154
83Myelodysplasia (HP:0002863)2.12729559
84Abnormality of pyrimidine metabolism (HP:0004353)2.12384491
85Personality changes (HP:0000751)2.10973662
86Basal cell carcinoma (HP:0002671)2.10054340
87Abnormality of T cells (HP:0002843)2.09005842
88Combined immunodeficiency (HP:0005387)2.08740502
89Chronic hepatic failure (HP:0100626)2.08554767
90Interstitial pulmonary disease (HP:0006530)2.05231081
91Meckel diverticulum (HP:0002245)2.04954735
92Myositis (HP:0100614)2.04243265
93Poor head control (HP:0002421)2.04228645
94Lymphopenia (HP:0001888)2.04084676
95Microretrognathia (HP:0000308)2.03919468
96Abnormality of chromosome stability (HP:0003220)2.03712051
97Cerebral hypomyelination (HP:0006808)2.03254483
98Poikiloderma (HP:0001029)2.02243593
99Neoplasm of the pancreas (HP:0002894)2.01280448
100Cleft eyelid (HP:0000625)1.99554431
101Pointed chin (HP:0000307)1.99176869
102Abnormality of the columella (HP:0009929)1.98489283
103T lymphocytopenia (HP:0005403)1.98378540
104Protruding tongue (HP:0010808)1.98195285
105Congenital stationary night blindness (HP:0007642)1.97933388
106Abnormality of the preputium (HP:0100587)1.97106850
107Hypoplasia of the thymus (HP:0000778)1.96558046
108Hypermelanotic macule (HP:0001034)1.96230193
109Abnormality of the motor neurons (HP:0002450)1.95228894
110Abnormal neuron morphology (HP:0012757)1.95228894
111Medulloblastoma (HP:0002885)1.95212379
112Abnormality of the ileum (HP:0001549)1.94614352
113Abnormality of T cell number (HP:0011839)1.94608474
114Osteomyelitis (HP:0002754)1.94128828
115Short thumb (HP:0009778)1.93738969
116Urticaria (HP:0001025)1.93620719
117Abnormal number of incisors (HP:0011064)1.93228493
118Abnormality of T cell physiology (HP:0011840)1.92993467
119Duplicated collecting system (HP:0000081)1.92939553
120Amaurosis fugax (HP:0100576)1.92247508
121Albinism (HP:0001022)1.91884077
122Aplasia/Hypoplasia of the thymus (HP:0010515)1.91033220
123Prominent nose (HP:0000448)1.90945382
124Papilloma (HP:0012740)1.89638687
125Verrucae (HP:0200043)1.89638687
126Supernumerary bones of the axial skeleton (HP:0009144)1.89405194
127Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.88566383
128Aplasia/Hypoplasia of the uvula (HP:0010293)1.87455001
129Leukopenia (HP:0001882)1.87388828
130Pancytopenia (HP:0001876)1.87328232
131Absent radius (HP:0003974)1.87320716
132Annular pancreas (HP:0001734)1.87217597
133Tented upper lip vermilion (HP:0010804)1.86986371
134Nausea (HP:0002018)1.86911255
135Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86164583
136Genetic anticipation (HP:0003743)1.84542333
137Truncal obesity (HP:0001956)1.83846448
138Broad distal phalanx of finger (HP:0009836)1.83679694
139Periodontitis (HP:0000704)1.82865273
140Intestinal fistula (HP:0100819)1.81874630
141Deep palmar crease (HP:0006191)1.81131999
142Hepatitis (HP:0012115)1.80275506
143IgG deficiency (HP:0004315)1.80173135
144Aseptic necrosis (HP:0010885)1.80046818
145Premature ovarian failure (HP:0008209)1.79352928
146Megaloblastic anemia (HP:0001889)1.79305417
147Abnormality of cells of the lymphoid lineage (HP:0012140)1.79136175
148Urethral obstruction (HP:0000796)1.78684907
149Abnormality of the aortic arch (HP:0012303)1.77454880
150Metaphyseal cupping (HP:0003021)1.76363886
151Granulocytopenia (HP:0001913)1.76250904
152Obsessive-compulsive behavior (HP:0000722)1.76210479
153Seborrheic dermatitis (HP:0001051)1.76065361
154High pitched voice (HP:0001620)1.73943763
155Aplasia/Hypoplasia of the sacrum (HP:0008517)1.73107840
156Leukocytosis (HP:0001974)1.72299309
157Chronic mucocutaneous candidiasis (HP:0002728)1.71065049
158Recurrent cutaneous fungal infections (HP:0011370)1.71065049
159Increased cerebral lipofuscin (HP:0011813)1.70983197
160Rhabdomyosarcoma (HP:0002859)1.70800372
161Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.67614446
162Gastrointestinal stroma tumor (HP:0100723)1.66334776
163Long eyelashes (HP:0000527)1.65986123

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.82419901
2WEE13.77544983
3MAP4K13.30458070
4SIK23.27199433
5SMG13.03650157
6CDC72.85729435
7NME22.57630682
8EIF2AK12.49793174
9BLK2.41963869
10TSSK62.10542148
11TESK22.08035583
12NEK22.07144949
13EIF2AK32.07133634
14ICK2.03889369
15SIK12.00579025
16STK101.95021610
17MAP3K101.87831460
18PIM21.83300148
19MAP3K111.79406601
20MAP3K131.64238569
21NEK11.58264111
22WNK41.55088157
23ZAP701.52888808
24RPS6KA41.52234839
25TNK21.51345036
26KDR1.51200318
27PRPF4B1.46597677
28FGFR41.45539349
29SCYL21.45453908
30BRSK21.45312227
31TYRO31.41467871
32MAP3K81.36842395
33CDK71.36305689
34MAPK111.36251310
35PLK11.35963147
36EPHA21.33954845
37SRPK11.32799305
38FES1.32689423
39PBK1.31749085
40TTK1.29620062
41PIM11.29501588
42ACVR1B1.28790394
43MAP2K31.28129898
44CAMK1D1.24386478
45CAMKK11.22920330
46TYK21.22560726
47ATR1.20463760
48CDK41.20454022
49LRRK21.19925332
50ITK1.15592742
51ALK1.15390522
52IRAK31.14155567
53BTK1.14059645
54MARK21.13543232
55PAK41.12907272
56RPS6KB21.12712682
57IKBKB1.11412109
58EEF2K1.11391994
59TBK11.09276821
60AURKB1.07723688
61TAOK31.01859136
62PASK1.01764083
63NME11.00737664
64MAP2K21.00371399
65TESK11.00274935
66MAP3K71.00178390
67CDK120.99761594
68MAPK150.97943311
69VRK20.97669489
70MAP2K60.96326112
71PLK40.95513441
72AURKA0.95027303
73FLT30.94510395
74TLK10.92128347
75ZAK0.91948979
76PKN20.91894398
77BRSK10.91531357
78HIPK20.89371113
79MTOR0.88505758
80RPS6KA60.87099748
81MAP3K140.86624889
82TGFBR10.85518318
83RIPK40.85468362
84CDC42BPA0.85431795
85GRK60.85276991
86CSF1R0.84477466
87ABL20.84096083
88KIT0.83122731
89JAK30.81984378
90STK40.81828265
91VRK10.80675684
92TRIB30.80302204
93TXK0.79970964
94EIF2AK20.78507064
95TEC0.78449818
96BRD40.77098794
97RPS6KL10.76864310
98RPS6KC10.76864310
99IRAK40.76572420
100SIK30.75293373
101CHEK10.74860599
102PTK60.74849032
103STK160.73864496
104TAOK20.72973466
105SYK0.72512795
106MKNK10.71917305
107CHUK0.71821114
108DYRK30.71458763
109PLK30.70876191
110CAMK1G0.70509052
111MAPK120.69303936
112MARK30.69065036
113ERN10.68819563
114MELK0.64640443
115CLK10.63166959
116CDK80.62253875
117MAPKAPK30.62070558
118PRKD20.61753628
119PAK10.61013510
120CHEK20.60090612
121TAOK10.59826706
122LYN0.57470000
123EPHB10.56459649
124PDK10.54930704
125DAPK10.54722359
126CDK20.54365389
127BMX0.54233120
128BRAF0.53147868
129CDK60.52276559
130PDPK10.52267610
131RPS6KA10.51807546
132RAF10.51764845
133RPS6KA50.51639327
134CSK0.50941375
135WNK10.49204052
136CSNK2A20.47318318
137TTN0.46951015
138PRKCQ0.46878047
139IKBKE0.46034106
140FGFR30.45950641
141LCK0.45011422
142MAP3K30.44989910
143CSNK2A10.44508569
144PRKCI0.43692594
145HCK0.43521298
146PRKCH0.43077367
147PDK20.42712490
148ATM0.42058725
149CAMK40.39971880

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.38810828
2Mismatch repair_Homo sapiens_hsa034303.47229071
3Proteasome_Homo sapiens_hsa030503.45471703
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.25163906
5Base excision repair_Homo sapiens_hsa034102.91081689
6Ribosome_Homo sapiens_hsa030102.85614963
7Spliceosome_Homo sapiens_hsa030402.81227866
8RNA polymerase_Homo sapiens_hsa030202.51671537
9RNA transport_Homo sapiens_hsa030132.51111751
10One carbon pool by folate_Homo sapiens_hsa006702.41140162
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.30248491
12Homologous recombination_Homo sapiens_hsa034402.21822896
13Nucleotide excision repair_Homo sapiens_hsa034202.14183461
14Pyrimidine metabolism_Homo sapiens_hsa002402.10060360
15Cell cycle_Homo sapiens_hsa041101.95687349
16Legionellosis_Homo sapiens_hsa051341.86116814
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.83730198
18Lysine degradation_Homo sapiens_hsa003101.70186250
19Leishmaniasis_Homo sapiens_hsa051401.66554815
20Non-small cell lung cancer_Homo sapiens_hsa052231.59843791
21p53 signaling pathway_Homo sapiens_hsa041151.53997632
22VEGF signaling pathway_Homo sapiens_hsa043701.46612893
23Epstein-Barr virus infection_Homo sapiens_hsa051691.44903607
24Fanconi anemia pathway_Homo sapiens_hsa034601.40047116
25Antigen processing and presentation_Homo sapiens_hsa046121.38331881
26Autoimmune thyroid disease_Homo sapiens_hsa053201.38276378
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.32273598
28Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.25806011
29Herpes simplex infection_Homo sapiens_hsa051681.23728045
30Non-homologous end-joining_Homo sapiens_hsa034501.21623396
31RNA degradation_Homo sapiens_hsa030181.18223652
32mRNA surveillance pathway_Homo sapiens_hsa030151.13019652
33Shigellosis_Homo sapiens_hsa051311.12424030
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09865751
35Apoptosis_Homo sapiens_hsa042101.09396056
36ABC transporters_Homo sapiens_hsa020101.07020137
37Graft-versus-host disease_Homo sapiens_hsa053321.06266479
38Primary immunodeficiency_Homo sapiens_hsa053401.06107371
39Measles_Homo sapiens_hsa051621.05729040
40Pentose phosphate pathway_Homo sapiens_hsa000301.04129227
41Viral carcinogenesis_Homo sapiens_hsa052031.03514423
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02746039
43Tuberculosis_Homo sapiens_hsa051521.02121452
44Pancreatic cancer_Homo sapiens_hsa052120.99536150
45mTOR signaling pathway_Homo sapiens_hsa041500.98916196
46Basal transcription factors_Homo sapiens_hsa030220.98563363
47Glycerophospholipid metabolism_Homo sapiens_hsa005640.96372612
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94132339
49Osteoclast differentiation_Homo sapiens_hsa043800.94088845
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.91029227
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86046361
52Influenza A_Homo sapiens_hsa051640.84083778
53Prolactin signaling pathway_Homo sapiens_hsa049170.83374631
54Choline metabolism in cancer_Homo sapiens_hsa052310.82476024
55Asthma_Homo sapiens_hsa053100.81328978
56Biosynthesis of amino acids_Homo sapiens_hsa012300.80992105
57Endometrial cancer_Homo sapiens_hsa052130.80361758
58Purine metabolism_Homo sapiens_hsa002300.79728279
59Selenocompound metabolism_Homo sapiens_hsa004500.78810194
60Hepatitis C_Homo sapiens_hsa051600.78368874
61Hematopoietic cell lineage_Homo sapiens_hsa046400.77995883
62Phagosome_Homo sapiens_hsa041450.76059713
63Hepatitis B_Homo sapiens_hsa051610.75893980
64B cell receptor signaling pathway_Homo sapiens_hsa046620.75813154
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.74824515
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74494695
67HTLV-I infection_Homo sapiens_hsa051660.74244323
68Acute myeloid leukemia_Homo sapiens_hsa052210.73936931
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73753618
70Allograft rejection_Homo sapiens_hsa053300.73578384
71Pertussis_Homo sapiens_hsa051330.73537877
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71397539
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.70726729
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.70147681
75Sulfur relay system_Homo sapiens_hsa041220.69767942
76Type I diabetes mellitus_Homo sapiens_hsa049400.69190792
77Inositol phosphate metabolism_Homo sapiens_hsa005620.68074141
78Folate biosynthesis_Homo sapiens_hsa007900.67820682
79Salmonella infection_Homo sapiens_hsa051320.67651207
80Bladder cancer_Homo sapiens_hsa052190.67631162
81Lysosome_Homo sapiens_hsa041420.67127111
82Insulin resistance_Homo sapiens_hsa049310.65968125
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65892030
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.65738965
85Systemic lupus erythematosus_Homo sapiens_hsa053220.64167336
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63531039
87Thyroid cancer_Homo sapiens_hsa052160.62799059
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62528061
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.62335536
90FoxO signaling pathway_Homo sapiens_hsa040680.61659875
91Malaria_Homo sapiens_hsa051440.61317057
92Prostate cancer_Homo sapiens_hsa052150.61247836
93Chemokine signaling pathway_Homo sapiens_hsa040620.60537897
94ErbB signaling pathway_Homo sapiens_hsa040120.60512672
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60046089
96MAPK signaling pathway_Homo sapiens_hsa040100.59283790
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58675017
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56044242
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54025879
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53859386
101TNF signaling pathway_Homo sapiens_hsa046680.53760996
102Staphylococcus aureus infection_Homo sapiens_hsa051500.53548646
103Viral myocarditis_Homo sapiens_hsa054160.51804748
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51523427
105Type II diabetes mellitus_Homo sapiens_hsa049300.51293758
106Rheumatoid arthritis_Homo sapiens_hsa053230.49725543
107HIF-1 signaling pathway_Homo sapiens_hsa040660.48689059
108Toxoplasmosis_Homo sapiens_hsa051450.47591597
109Chronic myeloid leukemia_Homo sapiens_hsa052200.47446234
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46834064
111Glutathione metabolism_Homo sapiens_hsa004800.46633579
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46356979
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.46099679
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45465135
115Carbon metabolism_Homo sapiens_hsa012000.45396987
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.45374483
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44510051
118Other glycan degradation_Homo sapiens_hsa005110.44358029
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43549482
120Small cell lung cancer_Homo sapiens_hsa052220.43451393
121Leukocyte transendothelial migration_Homo sapiens_hsa046700.43222452
122T cell receptor signaling pathway_Homo sapiens_hsa046600.40475737
123Renal cell carcinoma_Homo sapiens_hsa052110.39862274
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39738754
125GnRH signaling pathway_Homo sapiens_hsa049120.39151181
126Fructose and mannose metabolism_Homo sapiens_hsa000510.37360780
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37359751
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37136414
129MicroRNAs in cancer_Homo sapiens_hsa052060.36987715
130Colorectal cancer_Homo sapiens_hsa052100.36931175
131Oocyte meiosis_Homo sapiens_hsa041140.36910743
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35605112
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33808759
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.32467064
135Notch signaling pathway_Homo sapiens_hsa043300.31467676
136N-Glycan biosynthesis_Homo sapiens_hsa005100.30667609

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