KLHDC7A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1valine metabolic process (GO:0006573)5.71720994
2regulation of gene silencing by RNA (GO:0060966)5.64552269
3regulation of posttranscriptional gene silencing (GO:0060147)5.64552269
4regulation of gene silencing by miRNA (GO:0060964)5.64552269
5biotin metabolic process (GO:0006768)5.59949558
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.29606426
7L-phenylalanine catabolic process (GO:0006559)5.29606426
8alpha-linolenic acid metabolic process (GO:0036109)5.24925909
9regulation of sequestering of triglyceride (GO:0010889)5.17058021
10primary alcohol catabolic process (GO:0034310)5.16399512
11axonemal dynein complex assembly (GO:0070286)5.07789454
12L-phenylalanine metabolic process (GO:0006558)5.07411989
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.07411989
14fatty acid beta-oxidation (GO:0006635)5.03577386
15fatty acid transmembrane transport (GO:1902001)4.95362262
16sulfur amino acid catabolic process (GO:0000098)4.93334812
17fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.91185293
18low-density lipoprotein particle clearance (GO:0034383)4.87248298
19positive regulation of fatty acid beta-oxidation (GO:0032000)4.84947509
20lysine catabolic process (GO:0006554)4.83796035
21lysine metabolic process (GO:0006553)4.83796035
22L-serine metabolic process (GO:0006563)4.80858282
23aromatic amino acid family catabolic process (GO:0009074)4.78845526
24cysteine metabolic process (GO:0006534)4.71310888
25acetyl-CoA metabolic process (GO:0006084)4.70791543
26fatty acid oxidation (GO:0019395)4.70280584
27carnitine shuttle (GO:0006853)4.63663816
28lipid oxidation (GO:0034440)4.62296658
29cellular glucuronidation (GO:0052695)4.59846961
30branched-chain amino acid metabolic process (GO:0009081)4.52505781
31complement activation, alternative pathway (GO:0006957)4.49996648
32fatty acid catabolic process (GO:0009062)4.49291611
33amino-acid betaine metabolic process (GO:0006577)4.48459737
34regulation of triglyceride catabolic process (GO:0010896)4.48191925
35branched-chain amino acid catabolic process (GO:0009083)4.47339419
36regulation of cell fate specification (GO:0042659)4.46259028
37short-chain fatty acid metabolic process (GO:0046459)4.44961006
38triglyceride catabolic process (GO:0019433)4.44322326
39uronic acid metabolic process (GO:0006063)4.43846875
40glucuronate metabolic process (GO:0019585)4.43846875
41exogenous drug catabolic process (GO:0042738)4.41631553
42indole-containing compound catabolic process (GO:0042436)4.41537809
43indolalkylamine catabolic process (GO:0046218)4.41537809
44tryptophan catabolic process (GO:0006569)4.41537809
45positive regulation of fatty acid oxidation (GO:0046321)4.37530650
46glycine metabolic process (GO:0006544)4.35818004
47serine family amino acid catabolic process (GO:0009071)4.27392431
48triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.26128350
49neutral lipid catabolic process (GO:0046461)4.25409626
50acylglycerol catabolic process (GO:0046464)4.25409626
51homocysteine metabolic process (GO:0050667)4.22645433
52serine family amino acid biosynthetic process (GO:0009070)4.21602006
53glyoxylate metabolic process (GO:0046487)4.20250801
54tryptophan metabolic process (GO:0006568)4.18861509
55urea cycle (GO:0000050)4.10899383
56urea metabolic process (GO:0019627)4.10899383
57bile acid biosynthetic process (GO:0006699)4.09909559
58acylglycerol homeostasis (GO:0055090)4.08760490
59triglyceride homeostasis (GO:0070328)4.08760490
60kynurenine metabolic process (GO:0070189)4.07818872
61monocarboxylic acid catabolic process (GO:0072329)4.07386968
62carnitine transport (GO:0015879)4.04000552
63amino-acid betaine transport (GO:0015838)4.04000552
642-oxoglutarate metabolic process (GO:0006103)4.03965315
65positive regulation of lipid catabolic process (GO:0050996)4.01081532
66ethanol metabolic process (GO:0006067)3.96024731
67regulation of fatty acid beta-oxidation (GO:0031998)3.95752040
68plasma lipoprotein particle clearance (GO:0034381)3.93221356
69carnitine transmembrane transport (GO:1902603)3.92938235
70ethanol oxidation (GO:0006069)3.91444773
71establishment of integrated proviral latency (GO:0075713)3.88117208
72protein complex localization (GO:0031503)3.87558962
73carnitine metabolic process (GO:0009437)3.87213136
74cilium or flagellum-dependent cell motility (GO:0001539)3.86834315
75quaternary ammonium group transport (GO:0015697)3.79395772
76brown fat cell differentiation (GO:0050873)3.79216989
77nitrogen cycle metabolic process (GO:0071941)3.78713125
78alpha-amino acid catabolic process (GO:1901606)3.77693649
79regulation of fatty acid oxidation (GO:0046320)3.77262479
80regulation of protein activation cascade (GO:2000257)3.76347424
81gap junction assembly (GO:0016264)3.75376342
82establishment of apical/basal cell polarity (GO:0035089)3.74476762
83positive regulation of SMAD protein import into nucleus (GO:0060391)3.71108514
84response to nitrosative stress (GO:0051409)3.71043415
85bile acid metabolic process (GO:0008206)3.70972488
86cellular amino acid catabolic process (GO:0009063)3.69522337
87carboxylic acid catabolic process (GO:0046395)3.68432995
88organic acid catabolic process (GO:0016054)3.68432995
89drug catabolic process (GO:0042737)3.67730987
90serine family amino acid metabolic process (GO:0009069)3.67316958
91paraxial mesoderm development (GO:0048339)3.67015326
92tricarboxylic acid metabolic process (GO:0072350)3.65384507
93regulation of complement activation (GO:0030449)3.63213814
94drug transmembrane transport (GO:0006855)3.58453432
95acyl-CoA biosynthetic process (GO:0071616)3.57404553
96thioester biosynthetic process (GO:0035384)3.57404553
97fatty acid homeostasis (GO:0055089)3.55513311
98triglyceride biosynthetic process (GO:0019432)3.52853594
99L-alpha-amino acid transmembrane transport (GO:1902475)3.52793829
100negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.51049764
101protein carboxylation (GO:0018214)3.50225812
102peptidyl-glutamic acid carboxylation (GO:0017187)3.50225812
103neutral lipid biosynthetic process (GO:0046460)3.50102858
104acylglycerol biosynthetic process (GO:0046463)3.50102858
105negative regulation of lipase activity (GO:0060192)3.49526459
106urate metabolic process (GO:0046415)3.47795532
107triglyceride metabolic process (GO:0006641)3.46442628
108aromatic amino acid family metabolic process (GO:0009072)3.44648323
109fatty-acyl-CoA biosynthetic process (GO:0046949)3.42654899
110pre-miRNA processing (GO:0031054)3.42195100
111white fat cell differentiation (GO:0050872)3.39953372
112cellular ketone body metabolic process (GO:0046950)3.39300575
113positive regulation of catenin import into nucleus (GO:0035413)3.38155249
114cellular modified amino acid catabolic process (GO:0042219)3.37616387
115tyrosine metabolic process (GO:0006570)3.37582934
116regulation of triglyceride metabolic process (GO:0090207)3.35699908
117nodal signaling pathway (GO:0038092)3.35266754
118regulation of cholesterol storage (GO:0010885)3.34145530
119positive regulation of fatty acid metabolic process (GO:0045923)3.33156308
120cilium movement (GO:0003341)3.33075955
121positive regulation of triglyceride metabolic process (GO:0090208)3.32363937
122phospholipid homeostasis (GO:0055091)3.30515048
123heterochromatin organization (GO:0070828)3.30456155
124acylglycerol metabolic process (GO:0006639)3.28889362
125regulation of stem cell maintenance (GO:2000036)3.28669019
126cellular protein complex localization (GO:0034629)3.28195812
127regulation of cholesterol metabolic process (GO:0090181)3.27341120
128aspartate family amino acid catabolic process (GO:0009068)3.26851925
129acyl-CoA metabolic process (GO:0006637)3.26590583
130thioester metabolic process (GO:0035383)3.26590583
131high-density lipoprotein particle remodeling (GO:0034375)3.26365633
132regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.25911593
133neutral lipid metabolic process (GO:0006638)3.23499022
134vitamin transmembrane transport (GO:0035461)3.23029233
135glomerular epithelial cell development (GO:0072310)3.16311276
136protein localization to kinetochore (GO:0034501)3.13238525
137regulation of fibrinolysis (GO:0051917)3.05808781
138anterior/posterior axis specification, embryo (GO:0008595)3.05539912
139regulation of cell fate commitment (GO:0010453)2.97719785
140negative regulation of cell fate specification (GO:0009996)2.97422334
141aminoglycoside antibiotic metabolic process (GO:0030647)2.96983699
142epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.92809376
143regulation of helicase activity (GO:0051095)2.91548992
144calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.91369646
145negative regulation of cell fate commitment (GO:0010454)2.90787359
146establishment or maintenance of monopolar cell polarity (GO:0061339)2.88442475
147establishment of monopolar cell polarity (GO:0061162)2.88442475
148lung-associated mesenchyme development (GO:0060484)2.86647204
149negative regulation of fibrinolysis (GO:0051918)2.83563306
150epoxygenase P450 pathway (GO:0019373)2.82721417
151motile cilium assembly (GO:0044458)2.78896718
152planar cell polarity pathway involved in neural tube closure (GO:0090179)2.78869654
153polyketide metabolic process (GO:0030638)2.78663896
154doxorubicin metabolic process (GO:0044598)2.78663896
155daunorubicin metabolic process (GO:0044597)2.78663896
156establishment of viral latency (GO:0019043)2.77681003
157regulation of SMAD protein import into nucleus (GO:0060390)2.77128860
158primary alcohol metabolic process (GO:0034308)2.74868404
159epithelial cilium movement (GO:0003351)2.71655589
160chromatin remodeling at centromere (GO:0031055)2.71148455
161omega-hydroxylase P450 pathway (GO:0097267)2.68530222
162notochord development (GO:0030903)2.66720963
163mitotic metaphase plate congression (GO:0007080)2.65215442
164response to mercury ion (GO:0046689)2.60265489
165fibrinolysis (GO:0042730)2.59683850
166CENP-A containing nucleosome assembly (GO:0034080)2.57633165
167nucleotide-sugar biosynthetic process (GO:0009226)2.56570264
168citrulline biosynthetic process (GO:0019240)2.54849003
169protein localization to chromosome, centromeric region (GO:0071459)2.53334547
170purine nucleobase biosynthetic process (GO:0009113)2.52894998
171DNA strand elongation involved in DNA replication (GO:0006271)2.50558388
172regulation of gene silencing (GO:0060968)2.49756468
173NADPH regeneration (GO:0006740)2.49372627
174lateral sprouting from an epithelium (GO:0060601)2.47528923
175regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.47255817
176DNA replication checkpoint (GO:0000076)2.46164031
177negative regulation of gene silencing (GO:0060969)2.45251032
178negative regulation of androgen receptor signaling pathway (GO:0060766)2.44091389
179regulation of apoptotic cell clearance (GO:2000425)2.43977809
180mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.43597743
181branching involved in salivary gland morphogenesis (GO:0060445)2.42344152
182negative regulation of sterol transport (GO:0032372)2.42208591
183negative regulation of cholesterol transport (GO:0032375)2.42208591
184regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.42091844
185negative regulation of telomerase activity (GO:0051974)2.41649715
186pyrimidine-containing compound transmembrane transport (GO:0072531)2.41584144

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.98429726
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.13167804
3* RXR_22158963_ChIP-Seq_LIVER_Mouse6.18454527
4E2F7_22180533_ChIP-Seq_HELA_Human5.83167408
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.29545923
6* LXR_22158963_ChIP-Seq_LIVER_Mouse5.06692259
7EGR1_23403033_ChIP-Seq_LIVER_Mouse4.39836783
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.01071737
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.96217341
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.80989288
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.80989288
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.80989288
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.61003379
14MYC_18555785_ChIP-Seq_MESCs_Mouse3.26016080
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.05597035
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.03588463
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.96461867
18CLOCK_20551151_ChIP-Seq_293T_Human2.69984362
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58671601
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.56914972
21TCF3_18692474_ChIP-Seq_MEFs_Mouse2.51737425
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.48972656
23NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.47472996
24AR_21909140_ChIP-Seq_LNCAP_Human2.45924858
25FOXM1_23109430_ChIP-Seq_U2OS_Human2.40247989
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.26605341
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.15951350
28MYC_19030024_ChIP-ChIP_MESCs_Mouse2.15475960
29NANOG_16153702_ChIP-ChIP_HESCs_Human2.07839116
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.88149020
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.87354491
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.86118166
33SOX2_18555785_ChIP-Seq_MESCs_Mouse1.85218566
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.80675062
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80500879
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.77834478
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76055386
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.75151709
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74904969
40TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.74833890
41GATA1_22025678_ChIP-Seq_K562_Human1.74128185
42TCF3_18692474_ChIP-Seq_MESCs_Mouse1.71452540
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.64629487
44* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61936374
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61012712
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57148638
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57064125
48SOX2_16153702_ChIP-ChIP_HESCs_Human1.55940491
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.49710259
50SOX2_18692474_ChIP-Seq_MEFs_Mouse1.47564943
51* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.46537069
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45762386
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42003991
54HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.39337634
55PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.37988213
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36179642
57ESR1_21235772_ChIP-Seq_MCF-7_Human1.33363569
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32706301
59SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.32519877
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31955794
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31404499
62NANOG_18692474_ChIP-Seq_MEFs_Mouse1.31128410
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.30771734
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29604973
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29565999
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28670757
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28230326
68SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26312255
69* HNF4A_19822575_ChIP-Seq_HepG2_Human1.24102503
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23612460
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23607919
72* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22835207
73* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22468821
74* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.21223759
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19847986
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19647663
77* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.18962159
78XRN2_22483619_ChIP-Seq_HELA_Human1.18421332
79ZNF263_19887448_ChIP-Seq_K562_Human1.18024478
80KAP1_27257070_Chip-Seq_ESCs_Mouse1.16346174
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15204193
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.15019740
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14996205
84NANOG_21062744_ChIP-ChIP_HESCs_Human1.14361985
85* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12826774
86SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12650117
87OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12607231
88ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11685928
89CHD1_26751641_Chip-Seq_LNCaP_Human1.11216053
90PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10509328
91* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.09738030
92TRIM28_21343339_ChIP-Seq_HEK293_Human1.09488273
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08548999
94GATA4_25053715_ChIP-Seq_YYC3_Human1.07618097
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06149105
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05940996
97ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04954391
98* FOXO3_23340844_ChIP-Seq_DLD1_Human1.02837435
99TP63_17297297_ChIP-ChIP_HaCaT_Human1.02171504
100EST1_17652178_ChIP-ChIP_JURKAT_Human1.01296055
101ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01208314
102* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.99805353
103PIAS1_25552417_ChIP-Seq_VCAP_Human0.99740343
104* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.98843024
105IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98411592
106AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98410643
107ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98363952
108TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98099035
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96979922
110SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95306687
111Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94729648
112JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.94388889
113* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93931290
114GABP_17652178_ChIP-ChIP_JURKAT_Human0.93348628
115MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92420545
116TTF2_22483619_ChIP-Seq_HELA_Human0.92358703
117POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91147173
118ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91055043
119SOX17_20123909_ChIP-Seq_XEN_Mouse0.90679284
120SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87292901
121ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86754232
122* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.86256794
123CDX2_20551321_ChIP-Seq_CACO-2_Human0.84859609
124GATA2_21666600_ChIP-Seq_HMVEC_Human0.83422981
125TBX20_22080862_ChIP-Seq_HEART_Mouse0.82889173
126TBX20_22328084_ChIP-Seq_HEART_Mouse0.82889173
127FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82779852
128NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81629759
129NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81629759
130THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.77022210
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.76907051
132BCAT_22108803_ChIP-Seq_LS180_Human0.76167651
133RXR_22108803_ChIP-Seq_LS180_Human0.75993289
134FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.75748026
135AHR_22903824_ChIP-Seq_MCF-7_Human0.75407701
136CDX2_19796622_ChIP-Seq_MESCs_Mouse0.75371412
137RXRA_24833708_ChIP-Seq_LIVER_Mouse0.73287620
138TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.72347951
139SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72069274
140AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.71629171
141HTT_18923047_ChIP-ChIP_STHdh_Human0.71424086
142PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.70851815
143ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.70291703
144AUTS2_25519132_ChIP-Seq_293T-REX_Human0.70227514
145SOX2_20726797_ChIP-Seq_SW620_Human0.70085016
146TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69425447
147FOXA1_25552417_ChIP-Seq_VCAP_Human0.69247991
148GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.68830980
149NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.66993698
150CJUN_26792858_Chip-Seq_BT549_Human0.66923232
151ERG_21242973_ChIP-ChIP_JURKAT_Human0.65437620
152CTNNB1_20460455_ChIP-Seq_HCT116_Human0.64595347
153GATA3_24758297_ChIP-Seq_MCF-7_Human0.63455843
154KAP1_22055183_ChIP-Seq_ESCs_Mouse0.62754207
155* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.62220539
156RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61317172
157ARNT_22903824_ChIP-Seq_MCF-7_Human0.61075480
158CEBPB_22108803_ChIP-Seq_LS180_Human0.60573904
159CDX2_22108803_ChIP-Seq_LS180_Human0.60535494
160EP300_21415370_ChIP-Seq_HL-1_Mouse0.60305566
161GBX2_23144817_ChIP-Seq_PC3_Human0.59815095
162BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59175030
163CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.55230641
164NR3C1_21868756_ChIP-Seq_MCF10A_Human0.53969839
165CBP_21632823_ChIP-Seq_H3396_Human0.52942374
166FOXM1_26456572_ChIP-Seq_MCF-7_Human0.52011408
167* SMAD4_21741376_ChIP-Seq_HESCs_Human0.51411826
168* GATA2_19941826_ChIP-Seq_K562_Human0.51179325
169GATA6_25053715_ChIP-Seq_YYC3_Human0.51015553
170ESR1_15608294_ChIP-ChIP_MCF-7_Human0.50947998
171STAT1_17558387_ChIP-Seq_HELA_Human0.50850857
172P63_26484246_Chip-Seq_KERATINOCYTES_Human0.50786186
173TCF4_18268006_ChIP-ChIP_LS174T_Human0.50403190
174TP63_23658742_ChIP-Seq_EP156T_Human0.50201777
175* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.50041436
176CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.48658344

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.24490923
2MP0005360_urolithiasis5.87818527
3MP0005670_abnormal_white_adipose5.13580384
4MP0005365_abnormal_bile_salt5.03455054
5MP0003941_abnormal_skin_development4.47748711
6MP0005085_abnormal_gallbladder_physiolo4.25698586
7MP0010329_abnormal_lipoprotein_level3.77832999
8MP0005666_abnormal_adipose_tissue3.39571471
9MP0008875_abnormal_xenobiotic_pharmacok3.33088312
10MP0004130_abnormal_muscle_cell3.06795170
11MP0003252_abnormal_bile_duct2.90419056
12MP0005332_abnormal_amino_acid2.86830956
13MP0003693_abnormal_embryo_hatching2.81717731
14MP0004133_heterotaxia2.70537197
15MP0002876_abnormal_thyroid_physiology2.61977771
16MP0002118_abnormal_lipid_homeostasis2.53959900
17MP0003718_maternal_effect2.48339728
18MP0003191_abnormal_cellular_cholesterol2.46901868
19MP0004957_abnormal_blastocyst_morpholog2.43883113
20MP0004019_abnormal_vitamin_homeostasis2.38795718
21MP0004185_abnormal_adipocyte_glucose2.38311284
22MP0005375_adipose_tissue_phenotype2.28078698
23MP0002971_abnormal_brown_adipose2.21398498
24MP0003195_calcinosis2.15702137
25MP0003890_abnormal_embryonic-extraembry2.11939419
26MP0010030_abnormal_orbit_morphology2.10883966
27MP0000609_abnormal_liver_physiology2.10464249
28MP0005377_hearing/vestibular/ear_phenot2.10009894
29MP0003878_abnormal_ear_physiology2.10009894
30MP0000537_abnormal_urethra_morphology2.08566918
31MP0003806_abnormal_nucleotide_metabolis2.05526896
32MP0001666_abnormal_nutrient_absorption1.97562483
33MP0002254_reproductive_system_inflammat1.94967565
34MP0003111_abnormal_nucleus_morphology1.81681074
35MP0005334_abnormal_fat_pad1.80981980
36MP0009643_abnormal_urine_homeostasis1.75285307
37MP0005319_abnormal_enzyme/_coenzyme1.71615297
38MP0009115_abnormal_fat_cell1.70677317
39MP0005535_abnormal_body_temperature1.65708796
40MP0002138_abnormal_hepatobiliary_system1.64353385
41MP0005584_abnormal_enzyme/coenzyme_acti1.60208488
42MP0001293_anophthalmia1.58476997
43MP0001661_extended_life_span1.57762873
44MP0003186_abnormal_redox_activity1.55702865
45MP0002837_dystrophic_cardiac_calcinosis1.53824080
46MP0003136_yellow_coat_color1.52975809
47MP0001730_embryonic_growth_arrest1.50370194
48MP0001764_abnormal_homeostasis1.49749434
49MP0005647_abnormal_sex_gland1.46662919
50MP0010352_gastrointestinal_tract_polyps1.46524288
51MP0008932_abnormal_embryonic_tissue1.43648604
52MP0005083_abnormal_biliary_tract1.43065435
53MP0003119_abnormal_digestive_system1.40178515
54MP0002697_abnormal_eye_size1.40090611
55MP0008438_abnormal_cutaneous_collagen1.39153330
56MP0009840_abnormal_foam_cell1.38931937
57MP0000003_abnormal_adipose_tissue1.36164050
58MP0003705_abnormal_hypodermis_morpholog1.35787520
59MP0001756_abnormal_urination1.35374575
60MP0003077_abnormal_cell_cycle1.35306262
61MP0005367_renal/urinary_system_phenotyp1.34380798
62MP0000516_abnormal_urinary_system1.34380798
63MP0010094_abnormal_chromosome_stability1.31085067
64MP0002970_abnormal_white_adipose1.30485924
65MP0003937_abnormal_limbs/digits/tail_de1.29746567
66MP0003690_abnormal_glial_cell1.28296868
67MP0002085_abnormal_embryonic_tissue1.27523830
68MP0000013_abnormal_adipose_tissue1.26658187
69MP0002084_abnormal_developmental_patter1.23768152
70MP0009703_decreased_birth_body1.22998558
71MP0002089_abnormal_postnatal_growth/wei1.22757080
72MP0001346_abnormal_lacrimal_gland1.21872219
73MP0002078_abnormal_glucose_homeostasis1.21743231
74MP0005501_abnormal_skin_physiology1.20958691
75MP0006292_abnormal_olfactory_placode1.20660353
76MP0001881_abnormal_mammary_gland1.17530705
77MP0001849_ear_inflammation1.14542518
78MP0008057_abnormal_DNA_replication1.11447965
79MP0005380_embryogenesis_phenotype1.10585386
80MP0001672_abnormal_embryogenesis/_devel1.10585386
81MP0010386_abnormal_urinary_bladder1.10462045
82MP0005448_abnormal_energy_balance1.10091200
83MP0002111_abnormal_tail_morphology1.09755695
84MP0003959_abnormal_lean_body1.08892840
85MP0010234_abnormal_vibrissa_follicle1.08019026
86MP0002653_abnormal_ependyma_morphology1.07423223
87MP0005275_abnormal_skin_tensile1.06998624
88MP0004043_abnormal_pH_regulation1.06359907
89MP0001286_abnormal_eye_development1.06102834
90MP0009379_abnormal_foot_pigmentation1.04931004
91MP0008789_abnormal_olfactory_epithelium1.03513510
92MP0002132_abnormal_respiratory_system1.03307270
93MP0006036_abnormal_mitochondrial_physio1.02538944
94MP0005636_abnormal_mineral_homeostasis1.01841800
95MP0000579_abnormal_nail_morphology1.00776325
96MP0008877_abnormal_DNA_methylation0.99864973
97MP0009053_abnormal_anal_canal0.98810812
98MP0003566_abnormal_cell_adhesion0.98648589
99MP0000350_abnormal_cell_proliferation0.98584284
100MP0008058_abnormal_DNA_repair0.97482820
101MP0003868_abnormal_feces_composition0.96894922
102MP0002233_abnormal_nose_morphology0.95172166
103MP0003984_embryonic_growth_retardation0.95116854
104MP0000762_abnormal_tongue_morphology0.93866800
105MP0002136_abnormal_kidney_physiology0.93785698
106MP0002080_prenatal_lethality0.93713078
107MP0009764_decreased_sensitivity_to0.93364145
108MP0002088_abnormal_embryonic_growth/wei0.92537327
109MP0001697_abnormal_embryo_size0.91073109
110MP0000049_abnormal_middle_ear0.88052842
111MP0000598_abnormal_liver_morphology0.87974704
112MP0002796_impaired_skin_barrier0.86191525
113MP0003011_delayed_dark_adaptation0.85673746
114MP0009780_abnormal_chondrocyte_physiolo0.85447450
115MP0002168_other_aberrant_phenotype0.83534117
116MP0005452_abnormal_adipose_tissue0.83489552
117MP0000534_abnormal_ureter_morphology0.83124883
118MP0005451_abnormal_body_composition0.82371892
119MP0004197_abnormal_fetal_growth/weight/0.82258771
120MP0003724_increased_susceptibility_to0.80832024
121MP0003953_abnormal_hormone_level0.80137311
122MP0009763_increased_sensitivity_to0.79159883
123MP0008007_abnormal_cellular_replicative0.78001070
124MP0009642_abnormal_blood_homeostasis0.77757467
125MP0005076_abnormal_cell_differentiation0.76826132
126MP0001485_abnormal_pinna_reflex0.76196649
127MP0001765_abnormal_ion_homeostasis0.75017323
128MP0003938_abnormal_ear_development0.73942383
129MP0000432_abnormal_head_morphology0.73627230
130MP0002086_abnormal_extraembryonic_tissu0.72158310
131MP0008961_abnormal_basal_metabolism0.71656168
132MP0002277_abnormal_respiratory_mucosa0.70542008
133MP0000428_abnormal_craniofacial_morphol0.70414091
134MP0000678_abnormal_parathyroid_gland0.70019901
135MP0002092_abnormal_eye_morphology0.69522848
136MP0003567_abnormal_fetal_cardiomyocyte0.68933938
137MP0002060_abnormal_skin_morphology0.68622857
138MP0005084_abnormal_gallbladder_morpholo0.67766671
139MP0000627_abnormal_mammary_gland0.67617317
140MP0000230_abnormal_systemic_arterial0.65823123
141MP0004782_abnormal_surfactant_physiolog0.65075155
142MP0004264_abnormal_extraembryonic_tissu0.62510671
143MP0000604_amyloidosis0.62452407
144MP0000538_abnormal_urinary_bladder0.62273657
145MP0005220_abnormal_exocrine_pancreas0.59978745
146MP0004272_abnormal_basement_membrane0.59638215
147MP0004147_increased_porphyrin_level0.57007723
148MP0005376_homeostasis/metabolism_phenot0.56806073
149MP0008469_abnormal_protein_level0.56083576
150MP0009697_abnormal_copulation0.54934976
151MP0009765_abnormal_xenobiotic_induced0.54251989
152MP0002166_altered_tumor_susceptibility0.54094810
153MP0006138_congestive_heart_failure0.52776958
154MP0005167_abnormal_blood-brain_barrier0.51053181
155MP0000427_abnormal_hair_cycle0.50726253
156MP0001177_atelectasis0.49865788
157MP0003045_fibrosis0.47724984
158MP0002928_abnormal_bile_duct0.47000998
159MP0003656_abnormal_erythrocyte_physiolo0.46991411
160MP0009672_abnormal_birth_weight0.46861947
161MP0008872_abnormal_physiological_respon0.46505299
162MP0005395_other_phenotype0.46166373
163MP0001501_abnormal_sleep_pattern0.43546705
164MP0000566_synostosis0.43409024
165MP0002069_abnormal_eating/drinking_beha0.42882730
166MP0002909_abnormal_adrenal_gland0.42799992
167MP0005058_abnormal_lysosome_morphology0.42014845
168MP0005266_abnormal_metabolism0.40410545

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)6.91346855
2Chronic bronchitis (HP:0004469)6.43901226
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.03373010
4Abnormality of serine family amino acid metabolism (HP:0010894)5.97025236
5Abnormality of glycine metabolism (HP:0010895)5.97025236
6Hyperglycinemia (HP:0002154)5.33507194
7Abnormal respiratory motile cilium physiology (HP:0012261)5.13757858
8Abnormal respiratory epithelium morphology (HP:0012253)5.11208590
9Abnormal respiratory motile cilium morphology (HP:0005938)5.11208590
10Rhinitis (HP:0012384)5.04138757
11Complement deficiency (HP:0004431)4.98379253
12Abnormal ciliary motility (HP:0012262)4.84210966
13Intrahepatic cholestasis (HP:0001406)4.76077371
14Hyperammonemia (HP:0001987)4.69424090
15Abnormality of fatty-acid metabolism (HP:0004359)4.67715819
16Xanthomatosis (HP:0000991)4.66186185
17Dynein arm defect of respiratory motile cilia (HP:0012255)4.64436474
18Absent/shortened dynein arms (HP:0200106)4.64436474
19Ketosis (HP:0001946)4.62582885
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.49463563
21Hypoglycemic coma (HP:0001325)4.44408254
22Abnormality of aromatic amino acid family metabolism (HP:0004338)4.42631634
23Deep venous thrombosis (HP:0002625)4.40946536
24Hyperlipoproteinemia (HP:0010980)4.15551417
25Ketoacidosis (HP:0001993)4.10270616
26Hypoalphalipoproteinemia (HP:0003233)3.92496516
27Hydroxyprolinuria (HP:0003080)3.87127547
28Abnormality of proline metabolism (HP:0010907)3.87127547
29Abnormality of monocarboxylic acid metabolism (HP:0010996)3.86232750
30Oligomenorrhea (HP:0000876)3.82800737
31Epidermoid cyst (HP:0200040)3.79688302
32Dicarboxylic aciduria (HP:0003215)3.73593359
33Abnormality of dicarboxylic acid metabolism (HP:0010995)3.73593359
34Bronchiectasis (HP:0002110)3.67104607
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.66302604
36Prolonged partial thromboplastin time (HP:0003645)3.60702429
37Abnormality of purine metabolism (HP:0004352)3.56307828
38Hypertriglyceridemia (HP:0002155)3.44054792
39Abnormality of complement system (HP:0005339)3.39250238
40Hypolipoproteinemia (HP:0010981)3.35650968
41Gout (HP:0001997)3.33492300
42Acanthosis nigricans (HP:0000956)3.31459436
43Generalized aminoaciduria (HP:0002909)3.31280567
44Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.30243886
45Abnormality of serum amino acid levels (HP:0003112)3.24081587
46Proximal tubulopathy (HP:0000114)3.18062756
47Septo-optic dysplasia (HP:0100842)3.15222443
48Abnormality of aspartate family amino acid metabolism (HP:0010899)3.10775331
49Hypobetalipoproteinemia (HP:0003563)3.05511168
50Abnormality of sulfur amino acid metabolism (HP:0004339)3.04713916
51Abnormality of nucleobase metabolism (HP:0010932)3.02523179
52Myocardial infarction (HP:0001658)2.98443415
53Renal salt wasting (HP:0000127)2.97941641
54Increased purine levels (HP:0004368)2.97047344
55Hyperuricemia (HP:0002149)2.97047344
56Joint hemorrhage (HP:0005261)2.88625869
57Choanal stenosis (HP:0000452)2.85753523
58Metabolic acidosis (HP:0001942)2.81433506
59Lethargy (HP:0001254)2.73381161
60Fat malabsorption (HP:0002630)2.71956030
61Hemorrhage of the eye (HP:0011885)2.71904332
62Hypercholesterolemia (HP:0003124)2.69522859
63Renal cortical cysts (HP:0000803)2.68676545
64Abnormality of the common coagulation pathway (HP:0010990)2.67746453
65Delayed CNS myelination (HP:0002188)2.67294069
66Pancreatitis (HP:0001733)2.66493850
67Partial duplication of thumb phalanx (HP:0009944)2.61596150
68Abnormality of the intrinsic pathway (HP:0010989)2.55727735
69Myoglobinuria (HP:0002913)2.54333157
70Maternal diabetes (HP:0009800)2.54196399
71Bifid scrotum (HP:0000048)2.51070430
72Rickets (HP:0002748)2.48228545
73Abnormality of chloride homeostasis (HP:0011422)2.46979212
74Nausea (HP:0002018)2.46943439
75Abnormality of the labia minora (HP:0012880)2.46442816
76Sensorimotor neuropathy (HP:0007141)2.45343125
77Pigmentary retinal degeneration (HP:0001146)2.45157694
78Systemic lupus erythematosus (HP:0002725)2.42685271
79Vomiting (HP:0002013)2.39326635
80Conjugated hyperbilirubinemia (HP:0002908)2.38125193
81Colon cancer (HP:0003003)2.37608700
82Abnormality of the salivary glands (HP:0010286)2.36885342
83Infertility (HP:0000789)2.36881931
84Vascular calcification (HP:0004934)2.32281266
85Multiple enchondromatosis (HP:0005701)2.32053188
86Abnormality of the lacrimal duct (HP:0011481)2.31428019
87Facial cleft (HP:0002006)2.31188053
88Abnormality of methionine metabolism (HP:0010901)2.28975265
89Skin nodule (HP:0200036)2.28376195
90Bronchitis (HP:0012387)2.27933726
91Hyperaldosteronism (HP:0000859)2.27575805
92Hypoglycemic seizures (HP:0002173)2.25981890
93Insulin-resistant diabetes mellitus (HP:0000831)2.21653254
94Spastic diplegia (HP:0001264)2.20933509
95Enlarged kidneys (HP:0000105)2.20462973
96Cardiovascular calcification (HP:0011915)2.19919620
97Aplasia involving bones of the extremities (HP:0009825)2.18405622
98Aplasia involving bones of the upper limbs (HP:0009823)2.18405622
99Aplasia of the phalanges of the hand (HP:0009802)2.18405622
100Selective tooth agenesis (HP:0001592)2.17445491
101Stenosis of the external auditory canal (HP:0000402)2.16761725
102Megaloblastic anemia (HP:0001889)2.16235135
103Hyperglycemia (HP:0003074)2.14360430
104Hepatocellular carcinoma (HP:0001402)2.13285143
105Insulin resistance (HP:0000855)2.13085280
106Brushfield spots (HP:0001088)2.11494289
107Bronchomalacia (HP:0002780)2.10327657
108Nasal polyposis (HP:0100582)2.10251830
109Partial duplication of the phalanx of hand (HP:0009999)2.09593189
110Steatorrhea (HP:0002570)2.09557429
111Methylmalonic aciduria (HP:0012120)2.07221077
112Hyperbilirubinemia (HP:0002904)2.02305660
113Osteomalacia (HP:0002749)2.00255690
114Hepatoblastoma (HP:0002884)1.99918205
115Limb hypertonia (HP:0002509)1.99391994
116Alkalosis (HP:0001948)1.98942071
117Absent septum pellucidum (HP:0001331)1.98562458
118Esophageal varix (HP:0002040)1.97618470
119Long foot (HP:0001833)1.97350375
120Abnormality of the dental root (HP:0006486)1.95016222
121Taurodontia (HP:0000679)1.95016222
122Abnormality of permanent molar morphology (HP:0011071)1.95016222
123Abnormality of pyrimidine metabolism (HP:0004353)1.94953883
124Increased muscle lipid content (HP:0009058)1.94686608
125Rhabdomyolysis (HP:0003201)1.93392162
126Median cleft lip (HP:0000161)1.92797163
127Irritability (HP:0000737)1.92672573
128Cerebral edema (HP:0002181)1.92388969
129Hyperactive renin-angiotensin system (HP:0000841)1.91564337
130Subcapsular cataract (HP:0000523)1.90889546
131Broad metatarsal (HP:0001783)1.90819124
132Abnormality of urine glucose concentration (HP:0011016)1.90448627
133Glycosuria (HP:0003076)1.90448627
134Abnormal cartilage morphology (HP:0002763)1.90212750
135Right ventricular cardiomyopathy (HP:0011663)1.89557696
136Abnormality of the middle phalanges of the toes (HP:0010183)1.89140044
137Tachypnea (HP:0002789)1.88900785
138Abnormality of renin-angiotensin system (HP:0000847)1.88681660
139Elevated hepatic transaminases (HP:0002910)1.88296055
140Abnormality of the nasolacrimal system (HP:0000614)1.87951508
141Male infertility (HP:0003251)1.87173285
142Increased circulating renin level (HP:0000848)1.86527972
143Hypokalemic alkalosis (HP:0001949)1.85549764
144Neonatal hypoglycemia (HP:0001998)1.85008188
145Nasolacrimal duct obstruction (HP:0000579)1.83377513
146Abnormality of the septum pellucidum (HP:0007375)1.82383253
147Neonatal onset (HP:0003623)1.82223545
148Abnormality of the renal cortex (HP:0011035)1.80634150
149Abnormality of sodium homeostasis (HP:0010931)1.79610562
150Abnormality of the dental pulp (HP:0006479)1.78996472
151Nephrolithiasis (HP:0000787)1.78623494
152Thyroid-stimulating hormone excess (HP:0002925)1.78459828
153Breast aplasia (HP:0100783)1.77903104
154Impulsivity (HP:0100710)1.75627060
155Abnormality of vitamin metabolism (HP:0100508)1.74587437
156Vaginal fistula (HP:0004320)1.73664139
157Bilateral microphthalmos (HP:0007633)1.73113122
158Nephroblastoma (Wilms tumor) (HP:0002667)1.72829716
159Abnormality of homocysteine metabolism (HP:0010919)1.72363610
160Homocystinuria (HP:0002156)1.72363610
161Abnormality of molar (HP:0011077)1.70466269
162Abnormality of molar morphology (HP:0011070)1.70466269
163Humeroradial synostosis (HP:0003041)1.70134677
164Synostosis involving the elbow (HP:0003938)1.70134677
165Hypomagnesemia (HP:0002917)1.69591746
166Hyperphosphaturia (HP:0003109)1.67363578
167Hyponatremia (HP:0002902)1.66728138
168Carpal bone hypoplasia (HP:0001498)1.66127596
169Reduced antithrombin III activity (HP:0001976)1.64373620
170Supernumerary spleens (HP:0009799)1.63285770
171Turricephaly (HP:0000262)1.61457311
172Aplasia/Hypoplasia of the breasts (HP:0010311)1.61158240
173Esophageal atresia (HP:0002032)1.60384705
174Abnormal lung lobation (HP:0002101)1.60128437

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.51802261
2SIK15.20428029
3CAMK1D4.47513165
4TTK3.53921726
5CAMK1G3.32408435
6TRIB33.30410435
7CDC73.27892753
8MST43.10836874
9VRK22.61505804
10LATS12.56660852
11ERN12.56547681
12INSRR2.54430051
13PDK32.52565466
14PDK42.52565466
15SMG12.50590169
16FRK2.48006978
17MAPK152.45351506
18NME12.41339365
19BRSK22.40566525
20MAP3K102.34138211
21FGFR42.28411967
22BUB12.25248925
23MST1R2.18311470
24TSSK62.10033007
25OXSR12.05518875
26MKNK22.00494825
27PBK1.91741224
28MKNK11.80773358
29PRKAA21.79806265
30PDK21.78748875
31TAF11.78091977
32STK38L1.74094998
33LMTK21.73290020
34RIPK11.70783316
35STK391.68413431
36FGFR21.64610696
37WNK41.63927771
38SRPK11.61962101
39PLK31.59994607
40WNK31.56196113
41PAK41.54760856
42WEE11.48076408
43MAP3K91.46115168
44TIE11.44383172
45STK241.42043871
46PLK11.36035249
47TNIK1.31913514
48FGFR31.23850590
49NEK11.23819032
50IRAK31.22257298
51AKT31.21261552
52STK161.17623893
53CDK121.16462815
54PRKAA11.10163815
55ALK1.09009352
56ZAK1.07771868
57EEF2K1.07016933
58PINK11.06627911
59DYRK21.06244195
60SGK31.05169968
61EIF2AK11.05087779
62FER1.04951227
63CHEK21.04802579
64TAOK31.04329013
65NEK91.03573862
66MAPK111.03225246
67SGK21.00786989
68RPS6KB20.99826255
69JAK10.99326361
70ERBB40.98422579
71STK380.98069600
72CDK60.95348692
73SGK4940.91017466
74SGK2230.91017466
75DAPK20.89555462
76VRK10.86909148
77PIK3CA0.86838625
78TGFBR20.86561233
79DYRK30.85889176
80PLK40.84875646
81BRSK10.84763734
82MAP3K70.82851822
83MAP2K40.82791646
84JAK20.81037764
85PTK60.81014019
86EIF2AK30.80550225
87CDK190.79570997
88NTRK10.78540117
89AURKB0.77145523
90PIK3CG0.75021703
91CDK70.73586543
92PDPK10.73188597
93PASK0.72149430
94NEK20.69825127
95CDK90.69623191
96NLK0.69217568
97EPHA20.67169275
98MAP2K10.65135573
99GSK3A0.63278929
100ATR0.63045967
101PRKACG0.61975327
102MELK0.59524360
103EPHB20.59255976
104CHEK10.58887155
105LATS20.57800680
106MTOR0.57641753
107PDGFRA0.56245874
108PRKCZ0.54512368
109NME20.54342788
110PHKG20.54309005
111PHKG10.54309005
112MET0.52921319
113CSNK1E0.51971263
114AURKA0.51523145
115MAP3K80.51188116
116IGF1R0.50238071
117PDK10.49503423
118EIF2AK20.49346404
119ATM0.49280159
120STK30.49218128
121MYLK0.49129861
122TNK20.48685077
123PKN20.48369950
124GRK10.48293059
125PRKG20.47002558
126NUAK10.46665790
127ERBB20.46308592
128TYK20.45710133
129MAP3K140.45235798
130EPHA30.44339756
131MATK0.44243494
132STK40.42917749
133MAP3K60.41116928
134PRKCH0.40618561
135PRKCI0.39753834
136ACVR1B0.39282928
137MAPK120.39226836
138PRKDC0.39116016
139CDK10.37743742
140CDK20.36004779
141BCR0.35744932
142MAP3K30.35436186
143PTK20.35125287
144CAMK10.33500510
145SGK10.32012446
146CSNK1G10.31510726
147ABL20.31508329
148EPHB10.30465107
149CSNK2A20.30071151
150IRAK10.30027284
151CSNK2A10.29628117
152FGFR10.29482945
153PRKD30.29233415
154BMX0.28170937
155NEK60.27461992
156DAPK10.27260599
157DMPK0.26722787
158CSNK1A10.26480260
159ICK0.26377768
160EGFR0.25097738
161CDK40.24785893
162RPS6KB10.23866646
163DDR20.23332173
164FLT30.23228520
165MAP3K20.23185281
166RET0.23079759
167PRKD10.22421315
168STK110.22344774
169BRD40.22120198
170INSR0.21410883

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.62323967
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.38299276
3Fatty acid degradation_Homo sapiens_hsa000713.26894256
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.17413354
5PPAR signaling pathway_Homo sapiens_hsa033202.98927834
6Fatty acid metabolism_Homo sapiens_hsa012122.94299014
7Nitrogen metabolism_Homo sapiens_hsa009102.86233394
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.82238440
9Fatty acid biosynthesis_Homo sapiens_hsa000612.46507547
10Tryptophan metabolism_Homo sapiens_hsa003802.41832931
11Butanoate metabolism_Homo sapiens_hsa006502.41319792
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.39227071
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.26375842
14Peroxisome_Homo sapiens_hsa041462.20519852
15beta-Alanine metabolism_Homo sapiens_hsa004102.17531010
16Arginine biosynthesis_Homo sapiens_hsa002202.15121065
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.14009186
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.09480502
19Pyruvate metabolism_Homo sapiens_hsa006202.07886339
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.99253715
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.90548182
22Caffeine metabolism_Homo sapiens_hsa002321.85650553
23Mismatch repair_Homo sapiens_hsa034301.83786283
24Complement and coagulation cascades_Homo sapiens_hsa046101.82676966
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.81590137
26DNA replication_Homo sapiens_hsa030301.70397424
27Glycerolipid metabolism_Homo sapiens_hsa005611.65906757
28Carbon metabolism_Homo sapiens_hsa012001.58581327
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56038867
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53611787
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.52672683
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44603953
33Phenylalanine metabolism_Homo sapiens_hsa003601.39700991
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38164396
35Fatty acid elongation_Homo sapiens_hsa000621.35630475
36Vitamin B6 metabolism_Homo sapiens_hsa007501.33523946
37Histidine metabolism_Homo sapiens_hsa003401.31163952
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.31013240
39Fat digestion and absorption_Homo sapiens_hsa049751.30219454
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30187453
41Chemical carcinogenesis_Homo sapiens_hsa052041.28489585
42Staphylococcus aureus infection_Homo sapiens_hsa051501.25553109
43Tyrosine metabolism_Homo sapiens_hsa003501.24477635
44Bile secretion_Homo sapiens_hsa049761.21836702
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.21545314
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21133220
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.21069983
48Proteasome_Homo sapiens_hsa030501.20049588
49Retinol metabolism_Homo sapiens_hsa008301.19859405
50Sulfur metabolism_Homo sapiens_hsa009201.17513022
51Spliceosome_Homo sapiens_hsa030401.14889397
52ABC transporters_Homo sapiens_hsa020101.12952370
53Starch and sucrose metabolism_Homo sapiens_hsa005001.11519986
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.11502388
55Ribosome_Homo sapiens_hsa030101.03946572
56RNA polymerase_Homo sapiens_hsa030201.03678903
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02569602
58Selenocompound metabolism_Homo sapiens_hsa004501.01472668
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99943063
60Lysine degradation_Homo sapiens_hsa003100.97979853
61Biosynthesis of amino acids_Homo sapiens_hsa012300.96604387
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.96534325
63Base excision repair_Homo sapiens_hsa034100.95164584
64RNA transport_Homo sapiens_hsa030130.92881575
65Vitamin digestion and absorption_Homo sapiens_hsa049770.89715272
66Huntingtons disease_Homo sapiens_hsa050160.88335429
67Tight junction_Homo sapiens_hsa045300.86628168
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81904952
69AMPK signaling pathway_Homo sapiens_hsa041520.79714298
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.77697440
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.77465749
72Cell cycle_Homo sapiens_hsa041100.77082046
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72784600
74Pentose phosphate pathway_Homo sapiens_hsa000300.72287352
75Insulin resistance_Homo sapiens_hsa049310.71075459
76Adherens junction_Homo sapiens_hsa045200.70861532
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70330913
78mRNA surveillance pathway_Homo sapiens_hsa030150.67524933
79Thyroid cancer_Homo sapiens_hsa052160.64566861
80Nucleotide excision repair_Homo sapiens_hsa034200.64285540
81Homologous recombination_Homo sapiens_hsa034400.63875741
82Non-homologous end-joining_Homo sapiens_hsa034500.62913113
83Arginine and proline metabolism_Homo sapiens_hsa003300.61934740
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61324129
85Folate biosynthesis_Homo sapiens_hsa007900.57025006
86p53 signaling pathway_Homo sapiens_hsa041150.55826162
87Glutathione metabolism_Homo sapiens_hsa004800.54124249
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53765214
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51785533
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50742234
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.50325295
92RNA degradation_Homo sapiens_hsa030180.49175094
93Sphingolipid metabolism_Homo sapiens_hsa006000.48621076
94Glucagon signaling pathway_Homo sapiens_hsa049220.48004211
95Hippo signaling pathway_Homo sapiens_hsa043900.43791187
96Sulfur relay system_Homo sapiens_hsa041220.43395828
97Metabolic pathways_Homo sapiens_hsa011000.42884261
98Fructose and mannose metabolism_Homo sapiens_hsa000510.42772336
99Pyrimidine metabolism_Homo sapiens_hsa002400.42699757
100Oxidative phosphorylation_Homo sapiens_hsa001900.40001028
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.39749681
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38994806
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38794452
104Insulin signaling pathway_Homo sapiens_hsa049100.38633665
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37845307
106Basal transcription factors_Homo sapiens_hsa030220.37594111
107Steroid biosynthesis_Homo sapiens_hsa001000.35634826
108Purine metabolism_Homo sapiens_hsa002300.34717197
109Basal cell carcinoma_Homo sapiens_hsa052170.33611732
110N-Glycan biosynthesis_Homo sapiens_hsa005100.33270767
111Protein digestion and absorption_Homo sapiens_hsa049740.29725864
112TGF-beta signaling pathway_Homo sapiens_hsa043500.27661395
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24657250
114Galactose metabolism_Homo sapiens_hsa000520.13975604
115Linoleic acid metabolism_Homo sapiens_hsa005910.13702907
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.13654790
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.07929332
118Prion diseases_Homo sapiens_hsa050200.07550256
119Renin-angiotensin system_Homo sapiens_hsa046140.07355884
120Thyroid hormone synthesis_Homo sapiens_hsa049180.05927077
121Arachidonic acid metabolism_Homo sapiens_hsa005900.05685224
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.02749248
123Ovarian steroidogenesis_Homo sapiens_hsa049130.02519693
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.00893557
125ECM-receptor interaction_Homo sapiens_hsa045120.00394887
126Renin secretion_Homo sapiens_hsa04924-0.0819495
127Circadian rhythm_Homo sapiens_hsa04710-0.0787356
128Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0784962
129Regulation of autophagy_Homo sapiens_hsa04140-0.0734387
130Hepatitis C_Homo sapiens_hsa05160-0.0706229
131Lysosome_Homo sapiens_hsa04142-0.0597699
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0485159
133Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0312785
134Mineral absorption_Homo sapiens_hsa04978-0.0265510
135One carbon pool by folate_Homo sapiens_hsa00670-0.0220600
136Type II diabetes mellitus_Homo sapiens_hsa04930-0.0089558

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