KLHDC7B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.55310401
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.29637686
3antigen processing and presentation of endogenous antigen (GO:0019883)6.21472452
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.66978188
5negative regulation of cell killing (GO:0031342)5.57988743
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.57988743
7type I interferon signaling pathway (GO:0060337)5.55744774
8cellular response to type I interferon (GO:0071357)5.55744774
9response to type I interferon (GO:0034340)5.53022751
10positive regulation of gamma-delta T cell activation (GO:0046645)5.36566853
11detection of bacterium (GO:0016045)4.94980760
12detection of other organism (GO:0098543)4.78281635
13vocalization behavior (GO:0071625)4.66939850
14regulation of bile acid biosynthetic process (GO:0070857)4.58879907
15modulation by symbiont of host defense response (GO:0052031)4.42574473
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.42574473
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.42574473
18positive regulation by organism of defense response of other organism involved in symbiotic interact4.42574473
19modulation by symbiont of host immune response (GO:0052553)4.42574473
20positive regulation by symbiont of host defense response (GO:0052509)4.42574473
21intestinal cholesterol absorption (GO:0030299)4.33488236
22leukocyte aggregation (GO:0070486)4.32390729
23immunoglobulin mediated immune response (GO:0016064)4.25268192
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.24715670
25positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.24387184
26positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.22815279
27neuromuscular process controlling posture (GO:0050884)4.19191363
28ionotropic glutamate receptor signaling pathway (GO:0035235)4.19159462
29regulation of short-term neuronal synaptic plasticity (GO:0048172)4.14104536
30triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.12211023
31response to interferon-alpha (GO:0035455)4.09179611
32macrophage activation involved in immune response (GO:0002281)3.99950275
33response to peptidoglycan (GO:0032494)3.98923191
34regulation of B cell receptor signaling pathway (GO:0050855)3.96630527
35interferon-gamma-mediated signaling pathway (GO:0060333)3.94990179
36regulation of gamma-delta T cell activation (GO:0046643)3.89008954
37negative regulation of lymphocyte mediated immunity (GO:0002707)3.86142796
38negative regulation of T cell mediated immunity (GO:0002710)3.85617577
39negative regulation of erythrocyte differentiation (GO:0045647)3.83893724
40intestinal absorption (GO:0050892)3.82359299
41neutrophil activation involved in immune response (GO:0002283)3.79753140
42glutamate receptor signaling pathway (GO:0007215)3.75439776
43NIK/NF-kappaB signaling (GO:0038061)3.74526377
44response to interferon-beta (GO:0035456)3.72479468
45negative thymic T cell selection (GO:0045060)3.71084137
46cerebellar granule cell differentiation (GO:0021707)3.69292101
47T cell migration (GO:0072678)3.63479505
48regulation of T cell tolerance induction (GO:0002664)3.61603443
49detection of external biotic stimulus (GO:0098581)3.58907389
50response to interleukin-15 (GO:0070672)3.58905574
51L-phenylalanine catabolic process (GO:0006559)3.58182562
52erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.58182562
53regulation of interferon-beta biosynthetic process (GO:0045357)3.55899744
54negative T cell selection (GO:0043383)3.55687011
55negative regulation of leukocyte mediated immunity (GO:0002704)3.54610525
56negative regulation of viral genome replication (GO:0045071)3.54186946
57thymic T cell selection (GO:0045061)3.50229077
58regulation of dendritic cell antigen processing and presentation (GO:0002604)3.48906855
59positive thymic T cell selection (GO:0045059)3.43685132
60germinal center formation (GO:0002467)3.42342851
61phospholipid efflux (GO:0033700)3.42323573
62regulation of gamma-delta T cell differentiation (GO:0045586)3.41968913
63cellular response to interleukin-15 (GO:0071350)3.39877629
64erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.38156732
65L-phenylalanine metabolic process (GO:0006558)3.38156732
66regulation of type I interferon-mediated signaling pathway (GO:0060338)3.38131769
67negative regulation of interleukin-12 production (GO:0032695)3.37382185
68tolerance induction (GO:0002507)3.36147535
69response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.36123102
70response to host immune response (GO:0052572)3.36123102
71regulation of glutamate receptor signaling pathway (GO:1900449)3.35451922
72B cell mediated immunity (GO:0019724)3.34884470
73cerebellar Purkinje cell differentiation (GO:0021702)3.34882258
74response to muramyl dipeptide (GO:0032495)3.34663284
75locomotory exploration behavior (GO:0035641)3.33666335
76antigen processing and presentation via MHC class Ib (GO:0002475)3.29876613
77embryonic retina morphogenesis in camera-type eye (GO:0060059)3.26695370
78long-term memory (GO:0007616)3.26654431
79response to host (GO:0075136)3.25097477
80response to host defenses (GO:0052200)3.25097477
81response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.25097477
82B cell receptor signaling pathway (GO:0050853)3.24195821
83T cell selection (GO:0045058)3.23289240
84regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.23136664
85regulation of tolerance induction (GO:0002643)3.22204974
86cholesterol efflux (GO:0033344)3.17461055
87exploration behavior (GO:0035640)3.17460374
88high-density lipoprotein particle remodeling (GO:0034375)3.16823425
89regulation of triglyceride catabolic process (GO:0010896)3.16475049
90synaptic transmission, glutamatergic (GO:0035249)3.15814263
91positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.14774768
92regulation of cholesterol esterification (GO:0010872)3.14311615
93positive regulation of interferon-alpha production (GO:0032727)3.13544533
94regulation of antigen processing and presentation (GO:0002577)3.12476952
95positive regulation of antigen processing and presentation (GO:0002579)3.12126791
96urea metabolic process (GO:0019627)3.11833125
97urea cycle (GO:0000050)3.11833125
98detection of biotic stimulus (GO:0009595)3.11663045
99synaptic vesicle maturation (GO:0016188)3.11565111
100drug catabolic process (GO:0042737)3.11374066
101gamma-aminobutyric acid transport (GO:0015812)3.10472667
102cellular extravasation (GO:0045123)3.09830970
103synaptic vesicle docking involved in exocytosis (GO:0016081)3.09221388
104negative regulation of innate immune response (GO:0045824)3.08800495
105positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.08779405
106synaptic vesicle exocytosis (GO:0016079)3.08769858
107regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.07921506
108defense response to protozoan (GO:0042832)3.03782294
109regulation of neuronal synaptic plasticity (GO:0048168)3.03762566
110nucleobase catabolic process (GO:0046113)3.02265846
111regulation of alpha-beta T cell proliferation (GO:0046640)3.01766943
112respiratory burst (GO:0045730)3.01717272
113positive regulation of B cell differentiation (GO:0045579)3.01490223
114aromatic amino acid family catabolic process (GO:0009074)3.00805819
115cell differentiation in hindbrain (GO:0021533)3.00208569
116regulation of B cell differentiation (GO:0045577)3.00195331
117cellular response to interferon-gamma (GO:0071346)2.98848384
118glutamate secretion (GO:0014047)2.98240374
119lymphocyte chemotaxis (GO:0048247)2.97306148
120neuronal action potential propagation (GO:0019227)2.96266495
121regulation of mast cell degranulation (GO:0043304)2.95768498
122dendritic spine morphogenesis (GO:0060997)2.95763923
123negative regulation of phagocytosis (GO:0050765)2.95573861
124positive regulation of type 2 immune response (GO:0002830)2.95464122
125regulation of T cell mediated cytotoxicity (GO:0001914)2.94328633
126negative regulation of cytokine production involved in immune response (GO:0002719)2.94299020
127neurotransmitter secretion (GO:0007269)2.93615097
128reverse cholesterol transport (GO:0043691)2.93008765
129cellular potassium ion homeostasis (GO:0030007)2.92965730
130myeloid cell activation involved in immune response (GO:0002275)2.92312680
131plasma lipoprotein particle assembly (GO:0034377)2.92227816
132positive regulation of T cell mediated cytotoxicity (GO:0001916)2.91126586
133bile acid biosynthetic process (GO:0006699)2.91004243
134cellular response to interferon-alpha (GO:0035457)2.90296469
135regulation of interferon-alpha production (GO:0032647)2.90050584
136plasma lipoprotein particle remodeling (GO:0034369)2.89470820
137protein-lipid complex remodeling (GO:0034368)2.89470820
138macromolecular complex remodeling (GO:0034367)2.89470820
139regulation of regulatory T cell differentiation (GO:0045589)2.88674661
140sodium ion export (GO:0071436)2.87728915
141kynurenine metabolic process (GO:0070189)2.87313898
142lymphocyte migration (GO:0072676)2.86930444
143negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.86859019
144regulation of natural killer cell mediated immunity (GO:0002715)2.86037931
145regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.86037931
146angiotensin maturation (GO:0002003)2.84656447
147response to protozoan (GO:0001562)2.83993627
148lipopolysaccharide-mediated signaling pathway (GO:0031663)2.83866728
149regulation of myeloid leukocyte mediated immunity (GO:0002886)2.83166135
150negative regulation of type 2 immune response (GO:0002829)2.81691257
151response to interferon-gamma (GO:0034341)2.80230030
152cellular response to interferon-beta (GO:0035458)2.79675513
153positive T cell selection (GO:0043368)2.79142825
154neuron-neuron synaptic transmission (GO:0007270)2.78778512
155positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.77702049
156negative regulation of sterol transport (GO:0032372)2.77065465
157negative regulation of cholesterol transport (GO:0032375)2.77065465
158regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.77045926
159protein-lipid complex assembly (GO:0065005)2.76275674
160membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.75112869
161regulation of excitatory postsynaptic membrane potential (GO:0060079)2.74970353
162nitrogen cycle metabolic process (GO:0071941)2.74645008
163cellular sodium ion homeostasis (GO:0006883)2.73203683
164neuromuscular process controlling balance (GO:0050885)2.73039558
165protein localization to synapse (GO:0035418)2.72472713
166positive regulation of dendritic spine morphogenesis (GO:0061003)2.68592866
167very-low-density lipoprotein particle assembly (GO:0034379)2.68346907
168cochlea development (GO:0090102)2.67916716
169potassium ion homeostasis (GO:0055075)2.67086609
170tryptophan catabolic process (GO:0006569)2.65788375
171indole-containing compound catabolic process (GO:0042436)2.65788375
172indolalkylamine catabolic process (GO:0046218)2.65788375
173regulation of synaptic vesicle exocytosis (GO:2000300)2.65768419
174layer formation in cerebral cortex (GO:0021819)2.65133216
175positive regulation of membrane potential (GO:0045838)2.64176431
176flavonoid metabolic process (GO:0009812)2.62042398
177triglyceride homeostasis (GO:0070328)2.59525752
178acylglycerol homeostasis (GO:0055090)2.59525752
179alpha-linolenic acid metabolic process (GO:0036109)2.58227791
180regulation of postsynaptic membrane potential (GO:0060078)2.57815859
181tryptophan metabolic process (GO:0006568)2.53088324
182righting reflex (GO:0060013)2.53070769
183positive regulation of dendritic spine development (GO:0060999)2.52559263
184coenzyme catabolic process (GO:0009109)2.51764928
185proline transport (GO:0015824)2.50220486
186glutamate metabolic process (GO:0006536)2.49096107
187glycine transport (GO:0015816)2.48762079
188lipoprotein metabolic process (GO:0042157)2.48570708
189cholesterol homeostasis (GO:0042632)2.46328718
190exogenous drug catabolic process (GO:0042738)2.45840302
191dicarboxylic acid biosynthetic process (GO:0043650)2.43850075
192detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.43687311
193detection of temperature stimulus involved in sensory perception (GO:0050961)2.43687311
194bile acid metabolic process (GO:0008206)2.42750740
195negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.42388071
196long-term synaptic potentiation (GO:0060291)2.41370699
197positive regulation of triglyceride lipase activity (GO:0061365)2.40655081
198positive regulation of lipoprotein lipase activity (GO:0051006)2.40655081
199regulation of dendritic spine morphogenesis (GO:0061001)2.40280874
200sterol homeostasis (GO:0055092)2.39993319

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.80912544
2EZH2_22144423_ChIP-Seq_EOC_Human3.95871428
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.46517592
4VDR_21846776_ChIP-Seq_THP-1_Human3.29237476
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.20145141
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06274235
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.97618830
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.97202795
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.95834425
10MYC_22102868_ChIP-Seq_BL_Human2.93536531
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.88737087
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.76851226
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.71492720
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66450013
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66450013
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55660363
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.54524299
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.53261743
19* MAF_26560356_Chip-Seq_TH1_Human2.50808258
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50206651
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.46391865
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.46194914
23DROSHA_22980978_ChIP-Seq_HELA_Human2.45531449
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43913450
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.43588069
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42975482
27VDR_24763502_ChIP-Seq_THP-1_Human2.41879983
28* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30000726
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.28067909
30* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26906245
31KDM2B_26808549_Chip-Seq_SUP-B15_Human2.25488400
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25370084
33STAT4_19710469_ChIP-ChIP_TH1__Mouse2.24395081
34MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24385514
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.18917789
36EZH2_27304074_Chip-Seq_ESCs_Mouse2.16754609
37UTX_26944678_Chip-Seq_JUKART_Human2.15783880
38TCF7_22412390_ChIP-Seq_EML_Mouse2.14098290
39EGR1_19374776_ChIP-ChIP_THP-1_Human2.12636848
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.12430349
41* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.11507493
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.10469290
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09660218
44* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.08946859
45MYB_26560356_Chip-Seq_TH2_Human2.07146137
46IRF8_27001747_Chip-Seq_BMDM_Mouse2.05941015
47KDM2B_26808549_Chip-Seq_DND41_Human2.04708761
48RXR_22158963_ChIP-Seq_LIVER_Mouse2.03509766
49RNF2_27304074_Chip-Seq_ESCs_Mouse2.03214315
50RUNX1_22412390_ChIP-Seq_EML_Mouse2.02129084
51MAF_26560356_Chip-Seq_TH2_Human2.00945977
52ELK3_25401928_ChIP-Seq_HUVEC_Human2.00086236
53GBX2_23144817_ChIP-Seq_PC3_Human1.99841548
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.95197883
55REST_21632747_ChIP-Seq_MESCs_Mouse1.93528054
56SPI1_23547873_ChIP-Seq_NB4_Human1.93334160
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.89875099
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89660457
59MYB_21317192_ChIP-Seq_ERMYB_Mouse1.87969521
60MYB_26560356_Chip-Seq_TH1_Human1.85303687
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81700359
62LXR_22158963_ChIP-Seq_LIVER_Mouse1.77644085
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.77589771
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77451490
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77189369
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.76899523
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74031461
68SPI1_23127762_ChIP-Seq_K562_Human1.73958939
69STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.73467550
70RUNX_20019798_ChIP-Seq_JUKART_Human1.70270145
71FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66031278
72* RACK7_27058665_Chip-Seq_MCF-7_Human1.65115801
73PPARA_22158963_ChIP-Seq_LIVER_Mouse1.62368383
74SCL_19346495_ChIP-Seq_HPC-7_Human1.59775204
75NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.57324921
76REST_18959480_ChIP-ChIP_MESCs_Mouse1.56746576
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48028381
78RARB_27405468_Chip-Seq_BRAIN_Mouse1.47531201
79MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46777339
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46692797
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.43874671
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43184502
83FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.41577994
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38749048
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37383232
86PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34927642
87GATA1_22025678_ChIP-Seq_K562_Human1.33681216
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.33024890
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28942534
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28657588
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28221399
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27569934
93CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27439287
94CTCF_27219007_Chip-Seq_Bcells_Human1.27074571
95BCOR_27268052_Chip-Seq_Bcells_Human1.27005439
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26526299
97EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26477683
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26367162
99SA1_27219007_Chip-Seq_ERYTHROID_Human1.26175000
100KDM2B_26808549_Chip-Seq_JURKAT_Human1.25981034
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24912200
102CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24743772
103GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24575329
104CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23969231
105GATA1_19941827_ChIP-Seq_MEL_Mouse1.23734612
106BCL6_27268052_Chip-Seq_Bcells_Human1.23605117
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22382548
108DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21803635
109RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19859175
110* GATA3_27048872_Chip-Seq_THYMUS_Human1.19245830
111VDR_22108803_ChIP-Seq_LS180_Human1.19002808
112P63_26484246_Chip-Seq_KERATINOCYTES_Human1.18563281
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17409970
114NCOR1_26117541_ChIP-Seq_K562_Human1.16857268
115PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16495968
116CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16277663
117* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16130487
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14410647
119P68_20966046_ChIP-Seq_HELA_Human1.11292514
120LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11055951
121ELF1_20517297_ChIP-Seq_JURKAT_Human1.10934525
122SMAD4_21799915_ChIP-Seq_A2780_Human1.10200879
123GATA1_19941826_ChIP-Seq_K562_Human1.09672500
124PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09354404
125CIITA_25753668_ChIP-Seq_RAJI_Human1.08633357
126ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08513658
127ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08382048
128SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07756095
129KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07655298
130TP53_20018659_ChIP-ChIP_R1E_Mouse1.07377515
131STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07375331
132AHR_22903824_ChIP-Seq_MCF-7_Human1.06882142
133SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05660240
134P300_19829295_ChIP-Seq_ESCs_Human1.04770844
135SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04208366
136BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03164122
137KDM2B_26808549_Chip-Seq_K562_Human1.03138179
138CDX2_20551321_ChIP-Seq_CACO-2_Human1.02897942
139ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01502726
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01191270
141PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00882645
142SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99311877
143RING1B_27294783_Chip-Seq_NPCs_Mouse0.99174379
144PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98976956
145WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98868665
146GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98659880
147AR_19668381_ChIP-Seq_PC3_Human0.98564051
148TAF15_26573619_Chip-Seq_HEK293_Human0.98275355
149SOX2_21211035_ChIP-Seq_LN229_Gbm0.96899461
150TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96708617
151SMC4_20622854_ChIP-Seq_HELA_Human0.96176412
152NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96153795
153TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95844630
154CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95087358
155CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94722304
156UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93870897
157ARNT_22903824_ChIP-Seq_MCF-7_Human0.93783146
158TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92981574
159PU_27001747_Chip-Seq_BMDM_Mouse0.92006441
160ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91271990
161CTCF_26484167_Chip-Seq_Bcells_Mouse0.90810924
162SMAD3_21741376_ChIP-Seq_EPCs_Human0.89903921
163TP53_18474530_ChIP-ChIP_U2OS_Human0.88011817
164PIAS1_25552417_ChIP-Seq_VCAP_Human0.87992904
165SMAD4_21741376_ChIP-Seq_HESCs_Human0.87579193
166VDR_24787735_ChIP-Seq_THP-1_Human0.87526075
167ESR2_21235772_ChIP-Seq_MCF-7_Human0.87360791
168RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.86560324
169RUNX1_27514584_Chip-Seq_MCF-7_Human0.86459943
170AR_25329375_ChIP-Seq_VCAP_Human0.85509701
171ZNF274_21170338_ChIP-Seq_K562_Hela0.85025841
172EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.84212297
173WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83590300
174CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82667337
175NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82658643
176CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82426347
177OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82142259
178TRIM28_21343339_ChIP-Seq_HEK293_Human0.81497234
179PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81464540
180FOXA2_19822575_ChIP-Seq_HepG2_Human0.81356600
181EP300_21415370_ChIP-Seq_HL-1_Mouse0.81222402
182ZFP281_18757296_ChIP-ChIP_E14_Mouse0.81115150
183* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80289810
184STAT3_23295773_ChIP-Seq_U87_Human0.80266657
185P53_22127205_ChIP-Seq_FIBROBLAST_Human0.79216687
186TOP2B_26459242_ChIP-Seq_MCF-7_Human0.78434278
187STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.77511378
188SMAD3_21741376_ChIP-Seq_HESCs_Human0.77388654
189ZFP57_27257070_Chip-Seq_ESCs_Mouse0.76520910
190AR_21572438_ChIP-Seq_LNCaP_Human0.76310170
191GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76130318
192LXR_22292898_ChIP-Seq_THP-1_Human0.76049845
193MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75442891

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.43985645
2MP0002139_abnormal_hepatobiliary_system4.43839555
3MP0004859_abnormal_synaptic_plasticity4.43197552
4MP0001835_abnormal_antigen_presentation3.86983942
5MP0003436_decreased_susceptibility_to3.86610282
6MP0005085_abnormal_gallbladder_physiolo3.52210832
7MP0003724_increased_susceptibility_to3.42195077
8MP0000685_abnormal_immune_system3.28461025
9MP0001790_abnormal_immune_system3.14131238
10MP0005387_immune_system_phenotype3.14131238
11MP0005671_abnormal_response_to3.10794817
12MP0003763_abnormal_thymus_physiology3.01197707
13MP0003880_abnormal_central_pattern2.94737668
14MP0001800_abnormal_humoral_immune2.92074750
15MP0003252_abnormal_bile_duct2.90850497
16MP0005025_abnormal_response_to2.89559505
17MP0009785_altered_susceptibility_to2.86860015
18MP0003303_peritoneal_inflammation2.85822176
19MP0004270_analgesia2.79348223
20MP0005000_abnormal_immune_tolerance2.76506912
21MP0005083_abnormal_biliary_tract2.76142664
22MP0003635_abnormal_synaptic_transmissio2.74851651
23MP0001666_abnormal_nutrient_absorption2.73580839
24MP0005365_abnormal_bile_salt2.68677291
25MP0008875_abnormal_xenobiotic_pharmacok2.63085549
26MP0002419_abnormal_innate_immunity2.59584830
27MP0002723_abnormal_immune_serum2.52791243
28MP0010329_abnormal_lipoprotein_level2.51616196
29MP0002452_abnormal_antigen_presenting2.45120901
30MP0002420_abnormal_adaptive_immunity2.42646512
31MP0001819_abnormal_immune_cell2.40865719
32MP0003300_gastrointestinal_ulcer2.34486131
33MP0002148_abnormal_hypersensitivity_rea2.34267299
34MP0009046_muscle_twitch2.32884794
35MP0006082_CNS_inflammation2.32815381
36MP0005377_hearing/vestibular/ear_phenot2.24352852
37MP0003878_abnormal_ear_physiology2.24352852
38MP0009745_abnormal_behavioral_response2.23232095
39MP0001486_abnormal_startle_reflex2.21439487
40MP0003879_abnormal_hair_cell2.17376585
41MP0001968_abnormal_touch/_nociception2.16977718
42MP0009333_abnormal_splenocyte_physiolog2.09130527
43MP0003329_amyloid_beta_deposits2.08699023
44MP0004947_skin_inflammation2.07624671
45MP0010155_abnormal_intestine_physiology2.07369665
46MP0002064_seizures2.03098292
47MP0004381_abnormal_hair_follicle2.01118268
48MP0002398_abnormal_bone_marrow1.99985468
49MP0002063_abnormal_learning/memory/cond1.98843685
50MP0006276_abnormal_autonomic_nervous1.97884726
51MP0001485_abnormal_pinna_reflex1.97232762
52MP0001873_stomach_inflammation1.95582239
53MP0002405_respiratory_system_inflammati1.94764113
54MP0000716_abnormal_immune_system1.92722856
55MP0002272_abnormal_nervous_system1.90948256
56MP0009379_abnormal_foot_pigmentation1.89824095
57MP0002396_abnormal_hematopoietic_system1.87052152
58MP0010234_abnormal_vibrissa_follicle1.86737256
59MP0001501_abnormal_sleep_pattern1.82549630
60MP0002822_catalepsy1.82115870
61MP0002572_abnormal_emotion/affect_behav1.81962297
62MP0003866_abnormal_defecation1.81053237
63MP0005084_abnormal_gallbladder_morpholo1.78214225
64MP0002736_abnormal_nociception_after1.77188722
65MP0003453_abnormal_keratinocyte_physiol1.75168508
66MP0001533_abnormal_skeleton_physiology1.74568335
67MP0008260_abnormal_autophagy1.73491196
68MP0000858_altered_metastatic_potential1.73225767
69MP0002166_altered_tumor_susceptibility1.63495140
70MP0001845_abnormal_inflammatory_respons1.61275325
71MP0009278_abnormal_bone_marrow1.60886173
72MP0000703_abnormal_thymus_morphology1.59438306
73MP0000465_gastrointestinal_hemorrhage1.58837991
74MP0004885_abnormal_endolymph1.58024051
75MP0005464_abnormal_platelet_physiology1.56981004
76MP0002184_abnormal_innervation1.56126793
77MP0002429_abnormal_blood_cell1.55645610
78MP0003191_abnormal_cellular_cholesterol1.54817153
79MP0001851_eye_inflammation1.54325132
80MP0002722_abnormal_immune_system1.53765389
81MP0005451_abnormal_body_composition1.52829812
82MP0001346_abnormal_lacrimal_gland1.50982491
83MP0005310_abnormal_salivary_gland1.49400694
84MP0001440_abnormal_grooming_behavior1.48161086
85MP0000689_abnormal_spleen_morphology1.45500865
86MP0009840_abnormal_foam_cell1.42602575
87MP0004510_myositis1.42521811
88MP0000604_amyloidosis1.41987051
89MP0010368_abnormal_lymphatic_system1.40917077
90MP0002734_abnormal_mechanical_nocicepti1.40467990
91MP0002796_impaired_skin_barrier1.39559248
92MP0005423_abnormal_somatic_nervous1.38658533
93MP0003172_abnormal_lysosome_physiology1.37443351
94MP0002735_abnormal_chemical_nociception1.36413325
95MP0008569_lethality_at_weaning1.35787093
96MP0008469_abnormal_protein_level1.34594914
97MP0005623_abnormal_meninges_morphology1.34163365
98MP0002102_abnormal_ear_morphology1.34133845
99MP0002067_abnormal_sensory_capabilities1.33868895
100MP0003806_abnormal_nucleotide_metabolis1.30851696
101MP0005058_abnormal_lysosome_morphology1.23828485
102MP0004019_abnormal_vitamin_homeostasis1.23634915
103MP0002254_reproductive_system_inflammat1.23549068
104MP0002118_abnormal_lipid_homeostasis1.19795508
105MP0004742_abnormal_vestibular_system1.19122662
106MP0001502_abnormal_circadian_rhythm1.18490559
107MP0002006_tumorigenesis1.17326839
108MP0003045_fibrosis1.15954867
109MP0003705_abnormal_hypodermis_morpholog1.15419627
110MP0003938_abnormal_ear_development1.14495918
111MP0005332_abnormal_amino_acid1.13787595
112MP0002557_abnormal_social/conspecific_i1.12619168
113MP0003566_abnormal_cell_adhesion1.11851019
114MP0004142_abnormal_muscle_tone1.11422101
115MP0001963_abnormal_hearing_physiology1.11314365
116MP0005397_hematopoietic_system_phenotyp1.11171842
117MP0001545_abnormal_hematopoietic_system1.11171842
118MP0002733_abnormal_thermal_nociception1.10248094
119MP0003448_altered_tumor_morphology1.09966932
120MP0005076_abnormal_cell_differentiation1.09898618
121MP0002277_abnormal_respiratory_mucosa1.07630008
122MP0003828_pulmonary_edema1.07255545
123MP0000955_abnormal_spinal_cord1.06540035
124MP0005448_abnormal_energy_balance1.06149607
125MP0000579_abnormal_nail_morphology1.05975660
126MP0000026_abnormal_inner_ear1.04781924
127MP0001216_abnormal_epidermal_layer1.04078893
128MP0002132_abnormal_respiratory_system1.03734057
129MP0001853_heart_inflammation1.02596556
130MP0002933_joint_inflammation1.01380625
131MP0001188_hyperpigmentation1.01265285
132MP0000490_abnormal_crypts_of1.00583748
133MP0000778_abnormal_nervous_system0.98298599
134MP0002066_abnormal_motor_capabilities/c0.97496924
135MP0001970_abnormal_pain_threshold0.97044918
136MP0004858_abnormal_nervous_system0.95793415
137MP0003690_abnormal_glial_cell0.93865225
138MP0003091_abnormal_cell_migration0.92989853
139MP0002998_abnormal_bone_remodeling0.91377578
140MP0004264_abnormal_extraembryonic_tissu0.90913136
141MP0009764_decreased_sensitivity_to0.89706385
142MP0004808_abnormal_hematopoietic_stem0.89616884
143MP0008961_abnormal_basal_metabolism0.89041621
144MP0005166_decreased_susceptibility_to0.88864939
145MP0005075_abnormal_melanosome_morpholog0.88821410
146MP0008874_decreased_physiological_sensi0.87191096
147MP0004043_abnormal_pH_regulation0.86644993
148MP0005535_abnormal_body_temperature0.86644363
149MP0002882_abnormal_neuron_morphology0.84298988
150MP0004085_abnormal_heartbeat0.84258180
151MP0005501_abnormal_skin_physiology0.83537155
152MP0003122_maternal_imprinting0.83056588
153MP0002138_abnormal_hepatobiliary_system0.81767681
154MP0009931_abnormal_skin_appearance0.81655656
155MP0005390_skeleton_phenotype0.81614513
156MP0003632_abnormal_nervous_system0.81061984
157MP0003868_abnormal_feces_composition0.80534916
158MP0001663_abnormal_digestive_system0.80470081
159MP0009763_increased_sensitivity_to0.79763422
160MP0002971_abnormal_brown_adipose0.79544542
161MP0004883_abnormal_blood_vessel0.78882797
162MP0002069_abnormal_eating/drinking_beha0.77636320
163MP0001348_abnormal_lacrimal_gland0.77552803
164MP0000427_abnormal_hair_cycle0.76189616
165MP0009384_cardiac_valve_regurgitation0.75983497
166MP0001664_abnormal_digestion0.75725822
167MP0005023_abnormal_wound_healing0.74099403
168MP0002060_abnormal_skin_morphology0.74088898
169MP0003183_abnormal_peptide_metabolism0.74065406
170MP0004811_abnormal_neuron_physiology0.72980438
171MP0002089_abnormal_postnatal_growth/wei0.72213537
172MP0001765_abnormal_ion_homeostasis0.72133033
173MP0002019_abnormal_tumor_incidence0.70914470
174MP0004185_abnormal_adipocyte_glucose0.69966349
175MP0002909_abnormal_adrenal_gland0.69717255
176MP0000377_abnormal_hair_follicle0.69503401
177MP0000678_abnormal_parathyroid_gland0.69342821
178MP0000609_abnormal_liver_physiology0.68409227
179MP0002928_abnormal_bile_duct0.68115008
180MP0005584_abnormal_enzyme/coenzyme_acti0.67154008
181MP0002229_neurodegeneration0.66620138
182MP0002877_abnormal_melanocyte_morpholog0.65484720
183MP0000534_abnormal_ureter_morphology0.63284365
184MP0005164_abnormal_response_to0.62804234
185MP0008872_abnormal_physiological_respon0.62345412
186MP0000462_abnormal_digestive_system0.61885491
187MP0003075_altered_response_to0.61103350
188MP0002876_abnormal_thyroid_physiology0.60184237
189MP0003795_abnormal_bone_structure0.60097255
190MP0003631_nervous_system_phenotype0.59122280
191MP0002752_abnormal_somatic_nervous0.58926183
192MP0000343_altered_response_to0.58848781
193MP0005621_abnormal_cell_physiology0.58846686
194MP0004924_abnormal_behavior0.58674944
195MP0005386_behavior/neurological_phenoty0.58674944
196MP0000639_abnormal_adrenal_gland0.56532575

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.65025315
2Hypobetalipoproteinemia (HP:0003563)5.41914017
3Myositis (HP:0100614)4.65312549
4Elevated erythrocyte sedimentation rate (HP:0003565)4.56078356
5Intrahepatic cholestasis (HP:0001406)4.49584935
6Recurrent abscess formation (HP:0002722)4.37887422
7Recurrent bacterial skin infections (HP:0005406)4.35906388
8Abnormality of macrophages (HP:0004311)4.32095347
9Increased IgE level (HP:0003212)4.26452138
10Orchitis (HP:0100796)4.22961743
11Focal motor seizures (HP:0011153)4.22327770
12Potter facies (HP:0002009)4.21106659
13Facial shape deformation (HP:0011334)4.21106659
14Focal seizures (HP:0007359)4.20494801
15Xanthomatosis (HP:0000991)4.03391634
16Deep venous thrombosis (HP:0002625)4.03276375
17Abnormality of glutamine family amino acid metabolism (HP:0010902)3.92301514
18Recurrent fungal infections (HP:0002841)3.88613520
19Myokymia (HP:0002411)3.86302356
20Visual hallucinations (HP:0002367)3.84460458
21Optic neuritis (HP:0100653)3.82489659
22Retrobulbar optic neuritis (HP:0100654)3.82489659
23Abnormality of monocarboxylic acid metabolism (HP:0010996)3.81615213
24Mediastinal lymphadenopathy (HP:0100721)3.72770713
25Abnormality of aromatic amino acid family metabolism (HP:0004338)3.71116857
26Meningitis (HP:0001287)3.70183236
27Chronic obstructive pulmonary disease (HP:0006510)3.59928720
28Obstructive lung disease (HP:0006536)3.59928720
29Chronic mucocutaneous candidiasis (HP:0002728)3.50545679
30Recurrent cutaneous fungal infections (HP:0011370)3.50545679
31Abnormal delayed hypersensitivity skin test (HP:0002963)3.48882077
32Hypolipoproteinemia (HP:0010981)3.47596363
33Conjugated hyperbilirubinemia (HP:0002908)3.47195092
34Gastrointestinal infarctions (HP:0005244)3.42426416
35Action tremor (HP:0002345)3.39703785
36Stomatitis (HP:0010280)3.36842590
37Recurrent viral infections (HP:0004429)3.36726586
38Abnormality of aspartate family amino acid metabolism (HP:0010899)3.34400995
39Vasculitis (HP:0002633)3.31507559
40Supranuclear gaze palsy (HP:0000605)3.20217665
41Prolonged partial thromboplastin time (HP:0003645)3.20147513
42Recurrent skin infections (HP:0001581)3.18390200
43Recurrent gram-negative bacterial infections (HP:0005420)3.17809398
44Acanthocytosis (HP:0001927)3.17510900
45Cellulitis (HP:0100658)3.17339990
46Spontaneous abortion (HP:0005268)3.16526410
47Gastrointestinal inflammation (HP:0004386)3.10725744
48Inflammation of the large intestine (HP:0002037)3.08548763
49Ventricular fibrillation (HP:0001663)3.04281665
50Epileptic encephalopathy (HP:0200134)2.99749526
51Gingivitis (HP:0000230)2.99599355
52Urticaria (HP:0001025)2.97466382
53Intention tremor (HP:0002080)2.96539031
54Encephalitis (HP:0002383)2.95174061
55Hyperglycinuria (HP:0003108)2.90953691
56Chronic otitis media (HP:0000389)2.88408001
57Agammaglobulinemia (HP:0004432)2.87858382
58Progressive cerebellar ataxia (HP:0002073)2.85894413
59Panhypogammaglobulinemia (HP:0003139)2.85787752
60Epidermoid cyst (HP:0200040)2.85561560
61Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.83431361
62Recurrent bronchitis (HP:0002837)2.82567743
63Poikilocytosis (HP:0004447)2.80808399
64Milia (HP:0001056)2.80402823
65Confusion (HP:0001289)2.78336263
66Pulmonary infiltrates (HP:0002113)2.76587209
67Chest pain (HP:0100749)2.73595643
68Pustule (HP:0200039)2.73191356
69Hypochromic microcytic anemia (HP:0004840)2.72997154
70Keratoconjunctivitis sicca (HP:0001097)2.72667498
71Fat malabsorption (HP:0002630)2.71940694
72Abnormal gallbladder physiology (HP:0012438)2.71377959
73Cholecystitis (HP:0001082)2.71377959
74Hypercholesterolemia (HP:0003124)2.69218511
75Right ventricular cardiomyopathy (HP:0011663)2.68265742
76Status epilepticus (HP:0002133)2.67371528
77Hyperlipoproteinemia (HP:0010980)2.67018775
78Polygenic inheritance (HP:0010982)2.64746697
79Hemoptysis (HP:0002105)2.64731049
80Skin ulcer (HP:0200042)2.63681331
81Hypergammaglobulinemia (HP:0010702)2.62999561
82Hypochromic anemia (HP:0001931)2.62414751
83Thick nail (HP:0001805)2.62405699
84Autoimmune hemolytic anemia (HP:0001890)2.61520322
85Increased IgM level (HP:0003496)2.61470038
86Spontaneous hematomas (HP:0007420)2.60978385
87Torticollis (HP:0000473)2.60881205
88Nasal polyposis (HP:0100582)2.60158988
89Prolonged bleeding time (HP:0003010)2.57136510
90Hydroxyprolinuria (HP:0003080)2.57079417
91Abnormality of proline metabolism (HP:0010907)2.57079417
92Abnormality of glycine metabolism (HP:0010895)2.54907340
93Abnormality of serine family amino acid metabolism (HP:0010894)2.54907340
94Febrile seizures (HP:0002373)2.54098358
95Joint hemorrhage (HP:0005261)2.53904688
96Granulocytopenia (HP:0001913)2.53348780
97Generalized tonic-clonic seizures (HP:0002069)2.51042873
98Abnormality of sulfur amino acid metabolism (HP:0004339)2.48781293
99Reticulocytosis (HP:0001923)2.46446821
100Ketoacidosis (HP:0001993)2.45395009
101Malnutrition (HP:0004395)2.45047804
102Osteomyelitis (HP:0002754)2.44060462
103Complement deficiency (HP:0004431)2.43359446
104Abnormal eating behavior (HP:0100738)2.43147743
105Keratoconjunctivitis (HP:0001096)2.42962009
106Abnormality of the lower motor neuron (HP:0002366)2.42244119
107Abnormal social behavior (HP:0012433)2.39860237
108Impaired social interactions (HP:0000735)2.39860237
109Abnormality of T cells (HP:0002843)2.38794473
110Hypoalphalipoproteinemia (HP:0003233)2.37290049
111Ketosis (HP:0001946)2.36029210
112Sepsis (HP:0100806)2.34871131
113Absence seizures (HP:0002121)2.34763767
114Cerebral inclusion bodies (HP:0100314)2.34464622
115Abnormality of the corticospinal tract (HP:0002492)2.33857420
116Neurofibrillary tangles (HP:0002185)2.33646246
117T lymphocytopenia (HP:0005403)2.32627923
118Petechiae (HP:0000967)2.31601391
119Lip pit (HP:0100267)2.30192511
120Loss of speech (HP:0002371)2.29796498
121Gastrointestinal stroma tumor (HP:0100723)2.29674085
122Dysdiadochokinesis (HP:0002075)2.29365885
123Lymphopenia (HP:0001888)2.29045033
124Premature loss of primary teeth (HP:0006323)2.28958167
125Epistaxis (HP:0000421)2.25540672
126Increased circulating renin level (HP:0000848)2.25267168
127Abnormality of T cell physiology (HP:0011840)2.24637905
128Recurrent corneal erosions (HP:0000495)2.24297331
129Hyperammonemia (HP:0001987)2.23839895
130Ileus (HP:0002595)2.21228576
131Morphological abnormality of the pyramidal tract (HP:0002062)2.20459799
132Atonic seizures (HP:0010819)2.19431411
133Chorioretinal atrophy (HP:0000533)2.18735857
134Abnormality of cells of the lymphoid lineage (HP:0012140)2.18724099
135Prolonged QT interval (HP:0001657)2.18623252
136Abnormality of T cell number (HP:0011839)2.18419846
137Abnormality of the nasal mucosa (HP:0000433)2.18328596
138Abnormal gallbladder morphology (HP:0012437)2.18312237
139Syncope (HP:0001279)2.18279634
140Cholelithiasis (HP:0001081)2.18134449
141Leukocytosis (HP:0001974)2.18118370
142Skin rash (HP:0000988)2.17947758
143Cheilitis (HP:0100825)2.14952773
144Annular pancreas (HP:0001734)2.13566446
145Focal dystonia (HP:0004373)2.13339726
146Arterial thrombosis (HP:0004420)2.12648380
147Neonatal onset (HP:0003623)2.11920523
148Abnormality of methionine metabolism (HP:0010901)2.11585290
149Postural instability (HP:0002172)2.11393961
150Craniofacial dystonia (HP:0012179)2.11072144
151Episodic fever (HP:0001954)2.10200614
152Abnormal blistering of the skin (HP:0008066)2.09439043
153Interstitial pulmonary disease (HP:0006530)2.09275212
154Hypertensive crisis (HP:0100735)2.06445701
155Skin nodule (HP:0200036)2.04986640
156Scanning speech (HP:0002168)2.04929958
157Anorexia (HP:0002039)2.03355421
158Abnormality of the pleura (HP:0002103)2.02946224
159IgM deficiency (HP:0002850)2.02348022
160Poor eye contact (HP:0000817)2.02277266
161Pulmonary embolism (HP:0002204)2.00354478
162Dysmetria (HP:0001310)1.99333591
163Restrictive lung disease (HP:0002091)1.99157306
164Gingival bleeding (HP:0000225)1.98762668
165Papilloma (HP:0012740)1.98752621
166Verrucae (HP:0200043)1.98752621
167Emphysema (HP:0002097)1.98574979
168Dialeptic seizures (HP:0011146)1.97188488
169Increased cerebral lipofuscin (HP:0011813)1.96926261
170Abnormality of the pericardium (HP:0001697)1.95284396
171Stereotypic behavior (HP:0000733)1.95107151
172Viral hepatitis (HP:0006562)1.93853799
173Late onset (HP:0003584)1.93767415
174Gangrene (HP:0100758)1.93605665
175Abnormality of the common coagulation pathway (HP:0010990)1.92733790
176Hemiplegia (HP:0002301)1.92201158
177Nail dystrophy (HP:0008404)1.91194206
178Tetraplegia (HP:0002445)1.90409363
179Increased serum ferritin (HP:0003281)1.90397423
180Microcytic anemia (HP:0001935)1.90160976
181Hyperbilirubinemia (HP:0002904)1.89168161
182Metaphyseal cupping (HP:0003021)1.89053696
183Growth hormone excess (HP:0000845)1.88417191
184Abnormality of the salivary glands (HP:0010286)1.88026002
185Colitis (HP:0002583)1.87371826
186Plantar hyperkeratosis (HP:0007556)1.86926360
187Hyperkalemia (HP:0002153)1.85896941
188Purpura (HP:0000979)1.84778847
189Abnormality of the fingertips (HP:0001211)1.84750708
190Metabolic acidosis (HP:0001942)1.84219073
191Sensorimotor neuropathy (HP:0007141)1.83021493
192Anxiety (HP:0000739)1.82171081
193Broad-based gait (HP:0002136)1.80722449
194Pigmentary retinal degeneration (HP:0001146)1.80239086
195Ankle clonus (HP:0011448)1.79388573
196Bundle branch block (HP:0011710)1.78393334
197Spastic gait (HP:0002064)1.76093026
198Gout (HP:0001997)1.75307864

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.97634414
2MAP4K14.24557209
3SIK34.13046215
4NTRK33.77011154
5ERN13.73438695
6MAP3K133.31851873
7TYK23.17783027
8SIK22.96972404
9PAK62.73736790
10ARAF2.68559236
11SIK12.59942540
12TNIK2.49329385
13EPHA42.31244706
14BLK2.19792521
15TRIB32.17696361
16IRAK42.15707717
17TNK22.12555877
18SMG12.07065747
19JAK32.06693176
20KSR22.04622603
21IKBKE2.00924675
22FGFR41.97899802
23DDR21.95649435
24DAPK21.91217082
25CSK1.90445990
26TBK11.87959888
27JAK11.87294303
28ZAP701.81923888
29MAP2K31.81154024
30NTRK21.80541191
31MAP3K31.74634241
32MAP3K141.74210566
33PRPF4B1.65237493
34FGR1.61112974
35UHMK11.59672544
36BTK1.57640133
37KIT1.56493317
38MINK11.43261411
39PTK2B1.42085634
40RIPK41.37613815
41MAP3K111.33554656
42RIPK11.31643909
43HIPK21.30880585
44TXK1.30557068
45HCK1.28189389
46FRK1.24136076
47SYK1.21974768
48KSR11.20868114
49FGFR31.19566130
50PAK31.18704780
51CDK121.16365077
52TESK21.16226269
53NME21.13376188
54NTRK11.13094772
55MAP3K61.11019513
56PRKD21.10715037
57LCK1.10606663
58MAP2K41.09691413
59IKBKB1.07887029
60MARK21.07037143
61MARK11.06505544
62AKT31.04124293
63CDK51.00997567
64JAK21.00730935
65LYN1.00579721
66EPHA21.00451970
67CSF1R0.99102349
68CAMK10.93735091
69GRK50.93371666
70FES0.92960855
71GRK60.92255185
72IRAK30.88747744
73PRKCG0.88532052
74STK160.87248441
75GRK10.87227400
76EPHA30.85580132
77ITK0.85173657
78IRAK20.84310476
79MAP3K40.83170042
80CAMK2G0.80535927
81TESK10.80466003
82CDK190.80013023
83PDPK10.79861840
84SGK4940.79149734
85SGK2230.79149734
86CAMK2B0.79114636
87EPHB10.78577201
88PKN10.77791014
89MAP3K100.77759245
90MAPK150.77611098
91PTK20.77215710
92PAK20.76641630
93IRAK10.74126455
94LMTK20.73919492
95CAMK2A0.73460053
96PTK60.72912459
97MAP3K10.72599965
98MST1R0.72218774
99CDC42BPA0.71676735
100CDK180.70487883
101MAPK130.70184042
102MARK30.69995006
103CASK0.69938857
104TAOK20.68898741
105PRKCH0.68852789
106MAPK70.67511336
107CDK150.67487709
108MAP3K70.67154050
109SGK20.65378265
110ICK0.65091654
111CAMK40.64986307
112BRAF0.64016649
113LRRK20.63960616
114ERBB30.63521380
115PDK10.61375718
116MAP2K60.60225953
117STK110.60044660
118NME10.59793262
119CDK140.59300886
120PHKG20.58944503
121PHKG10.58944503
122BCR0.57709516
123CAMKK10.57537931
124ADRBK20.57406453
125CDK40.57010395
126MAP2K10.56605323
127MAPK110.56315191
128TAOK30.56156430
129CAMKK20.56137368
130MAPKAPK20.56115689
131OXSR10.56092731
132CHUK0.55870240
133DYRK1A0.55520843
134CDK11A0.54658299
135TEC0.53306601
136BMX0.52906867
137STK100.52501128
138INSRR0.51776312
139TAOK10.51677404
140STK380.51489025
141MOS0.51207573
142MAP3K20.50982195
143MET0.50936773
144ADRBK10.50429971
145SGK30.49884303
146PRKCZ0.49884014
147FER0.49769407
148ERBB20.49676927
149RET0.48952334
150FYN0.48657908
151NLK0.47981020
152PRKD30.47040083
153PKN20.46928291
154ERBB40.45545231
155PRKCE0.44069132
156MATK0.43845279
157MAPK120.43490597
158CAMK2D0.43193252
159DYRK1B0.43155505
160MAP2K70.42757973
161YES10.41092168
162PRKCQ0.38421560
163RPS6KC10.38400763
164RPS6KL10.38400763
165MAP2K20.33580571
166KDR0.33416091
167CDK90.28464378
168MAPK30.28015151

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.89298842
2Nicotine addiction_Homo sapiens_hsa050332.85514112
3Allograft rejection_Homo sapiens_hsa053302.75948494
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.73925210
5Primary immunodeficiency_Homo sapiens_hsa053402.71905674
6Graft-versus-host disease_Homo sapiens_hsa053322.64629076
7Leishmaniasis_Homo sapiens_hsa051402.64033804
8Autoimmune thyroid disease_Homo sapiens_hsa053202.61775069
9Osteoclast differentiation_Homo sapiens_hsa043802.51318142
10Fat digestion and absorption_Homo sapiens_hsa049752.33189308
11Measles_Homo sapiens_hsa051622.29084507
12Arginine biosynthesis_Homo sapiens_hsa002202.25718458
13Acute myeloid leukemia_Homo sapiens_hsa052212.23279038
14B cell receptor signaling pathway_Homo sapiens_hsa046622.21740407
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.18447674
16Staphylococcus aureus infection_Homo sapiens_hsa051502.17040411
17Bile secretion_Homo sapiens_hsa049762.14262112
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.13822424
19Toll-like receptor signaling pathway_Homo sapiens_hsa046202.04384323
20Influenza A_Homo sapiens_hsa051642.03560550
21Antigen processing and presentation_Homo sapiens_hsa046122.01749813
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.99843910
23Herpes simplex infection_Homo sapiens_hsa051681.96607454
24Type I diabetes mellitus_Homo sapiens_hsa049401.95182018
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.91890212
26Tuberculosis_Homo sapiens_hsa051521.85202486
27Viral myocarditis_Homo sapiens_hsa054161.83404571
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.82099054
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.81834877
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.75076155
31Glutamatergic synapse_Homo sapiens_hsa047241.74395072
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.74275908
33T cell receptor signaling pathway_Homo sapiens_hsa046601.72525717
34Toxoplasmosis_Homo sapiens_hsa051451.70294063
35Hepatitis C_Homo sapiens_hsa051601.66948835
36Asthma_Homo sapiens_hsa053101.65728288
37Amphetamine addiction_Homo sapiens_hsa050311.62682986
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.62128682
39Synaptic vesicle cycle_Homo sapiens_hsa047211.61990092
40Circadian entrainment_Homo sapiens_hsa047131.60192846
41Tryptophan metabolism_Homo sapiens_hsa003801.55983164
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.53900057
43GABAergic synapse_Homo sapiens_hsa047271.51501396
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.49887731
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48970752
46Long-term potentiation_Homo sapiens_hsa047201.46550987
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45123824
48Salivary secretion_Homo sapiens_hsa049701.44751548
49Malaria_Homo sapiens_hsa051441.43806923
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43000036
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42515062
52Starch and sucrose metabolism_Homo sapiens_hsa005001.41075417
53Hematopoietic cell lineage_Homo sapiens_hsa046401.39730502
54TNF signaling pathway_Homo sapiens_hsa046681.38774272
55Caffeine metabolism_Homo sapiens_hsa002321.37605177
56Chemokine signaling pathway_Homo sapiens_hsa040621.35800874
57Hepatitis B_Homo sapiens_hsa051611.35562173
58Pancreatic cancer_Homo sapiens_hsa052121.35527512
59Jak-STAT signaling pathway_Homo sapiens_hsa046301.35442522
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34448203
61Vitamin digestion and absorption_Homo sapiens_hsa049771.34326928
62NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34308481
63Olfactory transduction_Homo sapiens_hsa047401.33182285
64Carbohydrate digestion and absorption_Homo sapiens_hsa049731.32790894
65Chronic myeloid leukemia_Homo sapiens_hsa052201.31295469
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.30375617
67Insulin secretion_Homo sapiens_hsa049111.30230010
68Morphine addiction_Homo sapiens_hsa050321.26502572
69Butanoate metabolism_Homo sapiens_hsa006501.25599176
70Non-small cell lung cancer_Homo sapiens_hsa052231.25526328
71African trypanosomiasis_Homo sapiens_hsa051431.25500041
72PPAR signaling pathway_Homo sapiens_hsa033201.25129534
73Mineral absorption_Homo sapiens_hsa049781.24323105
74Steroid hormone biosynthesis_Homo sapiens_hsa001401.23323050
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21715148
76Histidine metabolism_Homo sapiens_hsa003401.19766063
77ABC transporters_Homo sapiens_hsa020101.18265191
78Gastric acid secretion_Homo sapiens_hsa049711.15554700
79Cocaine addiction_Homo sapiens_hsa050301.14884870
80Notch signaling pathway_Homo sapiens_hsa043301.13913441
81Complement and coagulation cascades_Homo sapiens_hsa046101.13802158
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12794669
83Cyanoamino acid metabolism_Homo sapiens_hsa004601.11829076
84Leukocyte transendothelial migration_Homo sapiens_hsa046701.08768562
85Taste transduction_Homo sapiens_hsa047421.08454942
86VEGF signaling pathway_Homo sapiens_hsa043701.08261725
87Renin-angiotensin system_Homo sapiens_hsa046141.07889920
88Other glycan degradation_Homo sapiens_hsa005111.07316576
89Fatty acid degradation_Homo sapiens_hsa000711.05115321
90Legionellosis_Homo sapiens_hsa051341.04241314
91Phagosome_Homo sapiens_hsa041451.02274591
92Renin secretion_Homo sapiens_hsa049241.02260260
93Apoptosis_Homo sapiens_hsa042101.01873112
94Epstein-Barr virus infection_Homo sapiens_hsa051691.00431203
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99743821
96Shigellosis_Homo sapiens_hsa051310.99368723
97Long-term depression_Homo sapiens_hsa047300.97981870
98Pertussis_Homo sapiens_hsa051330.97890003
99Prolactin signaling pathway_Homo sapiens_hsa049170.97798459
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97414419
101Dopaminergic synapse_Homo sapiens_hsa047280.97221028
102Viral carcinogenesis_Homo sapiens_hsa052030.93314665
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90485157
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90078579
105GnRH signaling pathway_Homo sapiens_hsa049120.89852267
106HTLV-I infection_Homo sapiens_hsa051660.87616837
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87317645
108Rheumatoid arthritis_Homo sapiens_hsa053230.85414893
109cAMP signaling pathway_Homo sapiens_hsa040240.84906367
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84573767
111Lysine degradation_Homo sapiens_hsa003100.84387674
112Cholinergic synapse_Homo sapiens_hsa047250.83663717
113Folate biosynthesis_Homo sapiens_hsa007900.83044479
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82726486
115Platelet activation_Homo sapiens_hsa046110.82586148
116Calcium signaling pathway_Homo sapiens_hsa040200.81574451
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.81205578
118Oxytocin signaling pathway_Homo sapiens_hsa049210.81170639
119Galactose metabolism_Homo sapiens_hsa000520.80683096
120Bladder cancer_Homo sapiens_hsa052190.80125461
121Protein digestion and absorption_Homo sapiens_hsa049740.80091662
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79744810
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79522314
124Chemical carcinogenesis_Homo sapiens_hsa052040.79445644
125Serotonergic synapse_Homo sapiens_hsa047260.77836384
126Salmonella infection_Homo sapiens_hsa051320.76288753
127Renal cell carcinoma_Homo sapiens_hsa052110.76109132
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75165461
129Phenylalanine metabolism_Homo sapiens_hsa003600.75039143
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74647549
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73929829
132beta-Alanine metabolism_Homo sapiens_hsa004100.72804479
133Fatty acid metabolism_Homo sapiens_hsa012120.72438407
134Dorso-ventral axis formation_Homo sapiens_hsa043200.72139351
135Endometrial cancer_Homo sapiens_hsa052130.71502711
136Type II diabetes mellitus_Homo sapiens_hsa049300.71446333
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71133500
138Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69920009
139Thyroid hormone synthesis_Homo sapiens_hsa049180.68505386
140Peroxisome_Homo sapiens_hsa041460.68481217
141Gap junction_Homo sapiens_hsa045400.68089046
142Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68025911
143Axon guidance_Homo sapiens_hsa043600.67496615
144Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67284151
145Thyroid cancer_Homo sapiens_hsa052160.66599326
146Endocytosis_Homo sapiens_hsa041440.66592740
147Circadian rhythm_Homo sapiens_hsa047100.65934352
1482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64016947
149Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63668475
150Sphingolipid signaling pathway_Homo sapiens_hsa040710.63304212
151Glycerolipid metabolism_Homo sapiens_hsa005610.62788052
152Colorectal cancer_Homo sapiens_hsa052100.62582948
153Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60314767
154Amoebiasis_Homo sapiens_hsa051460.58450757
155Collecting duct acid secretion_Homo sapiens_hsa049660.58186604
156Choline metabolism in cancer_Homo sapiens_hsa052310.58058324
157Glucagon signaling pathway_Homo sapiens_hsa049220.57912005
158Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57345637
159Glycerophospholipid metabolism_Homo sapiens_hsa005640.57247623
160Drug metabolism - other enzymes_Homo sapiens_hsa009830.56471073
161Lysosome_Homo sapiens_hsa041420.56325030
162Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56024096
163Adipocytokine signaling pathway_Homo sapiens_hsa049200.55979556
164Vascular smooth muscle contraction_Homo sapiens_hsa042700.55806273
165Melanogenesis_Homo sapiens_hsa049160.55757775
166Insulin resistance_Homo sapiens_hsa049310.55117089
167Retinol metabolism_Homo sapiens_hsa008300.54321302
168Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54280938
169Tyrosine metabolism_Homo sapiens_hsa003500.53896036
170Estrogen signaling pathway_Homo sapiens_hsa049150.53322660
171Inositol phosphate metabolism_Homo sapiens_hsa005620.53251194
172Central carbon metabolism in cancer_Homo sapiens_hsa052300.52893360
173Pancreatic secretion_Homo sapiens_hsa049720.52711209
174Sulfur metabolism_Homo sapiens_hsa009200.52112852
175cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51684568
176Prion diseases_Homo sapiens_hsa050200.51531833
177Phospholipase D signaling pathway_Homo sapiens_hsa040720.51455100
178Glioma_Homo sapiens_hsa052140.51102748
179FoxO signaling pathway_Homo sapiens_hsa040680.51096192
180Small cell lung cancer_Homo sapiens_hsa052220.50416303
181mTOR signaling pathway_Homo sapiens_hsa041500.50337753
182Fatty acid biosynthesis_Homo sapiens_hsa000610.48241416
183Prostate cancer_Homo sapiens_hsa052150.47502024
184Arginine and proline metabolism_Homo sapiens_hsa003300.46156234
185ErbB signaling pathway_Homo sapiens_hsa040120.45995110
186Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45516400
187Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44911256
188Glycosaminoglycan degradation_Homo sapiens_hsa005310.43582612
189Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42411443
190HIF-1 signaling pathway_Homo sapiens_hsa040660.41013245
191SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38484673
192Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37634390
193Insulin signaling pathway_Homo sapiens_hsa049100.35794991
194MAPK signaling pathway_Homo sapiens_hsa040100.35030710
195Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32917777

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »