KLHDC8A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a kelch domain-containing protein which is upregulated in cancer. Upregulated expression of the encoded protein may provide an alternative pathway for tumors to maintain aggressiveness in the absence of epidermal growth factor receptor dependence. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.93570170
2postsynaptic membrane organization (GO:0001941)5.69030287
3presynaptic membrane assembly (GO:0097105)5.58391719
4nucleobase catabolic process (GO:0046113)5.40156235
5presynaptic membrane organization (GO:0097090)5.33629129
6behavioral response to nicotine (GO:0035095)5.04743166
7C21-steroid hormone biosynthetic process (GO:0006700)4.86879647
8response to pheromone (GO:0019236)4.31005762
9glucocorticoid biosynthetic process (GO:0006704)4.21750982
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.19840051
11neuronal stem cell maintenance (GO:0097150)4.19029447
12cerebral cortex radially oriented cell migration (GO:0021799)4.04383619
13olfactory bulb development (GO:0021772)4.03600124
14negative regulation of cytosolic calcium ion concentration (GO:0051481)4.00068685
15regulation of short-term neuronal synaptic plasticity (GO:0048172)3.97374509
16mechanosensory behavior (GO:0007638)3.95059202
17synaptic vesicle maturation (GO:0016188)3.94807297
18retinal ganglion cell axon guidance (GO:0031290)3.93684489
19ganglion development (GO:0061548)3.90838623
20auditory behavior (GO:0031223)3.90107760
21synaptic vesicle exocytosis (GO:0016079)3.89651451
22sodium ion export (GO:0071436)3.86674220
23forebrain neuron differentiation (GO:0021879)3.84475777
24regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.79580123
25potassium ion homeostasis (GO:0055075)3.78291190
26cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.78039455
27central nervous system projection neuron axonogenesis (GO:0021952)3.77860532
28glucocorticoid metabolic process (GO:0008211)3.76622190
29plasma membrane repair (GO:0001778)3.72596005
30calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.72365059
31mating behavior (GO:0007617)3.59633774
32synaptic vesicle docking involved in exocytosis (GO:0016081)3.59583628
33cellular potassium ion homeostasis (GO:0030007)3.55253799
34synapse assembly (GO:0007416)3.54343001
35cell communication by electrical coupling (GO:0010644)3.51948382
36glutamate secretion (GO:0014047)3.49227853
37establishment of mitochondrion localization (GO:0051654)3.47209170
38spinal cord association neuron differentiation (GO:0021527)3.43455675
39negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.40206422
40substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.39449298
41substrate-independent telencephalic tangential migration (GO:0021826)3.39449298
42regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.33539395
43spinal cord development (GO:0021510)3.31033416
44layer formation in cerebral cortex (GO:0021819)3.28070620
45appendage development (GO:0048736)3.25518386
46limb development (GO:0060173)3.25518386
47positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.24671237
48positive regulation of synapse assembly (GO:0051965)3.24569931
49toxin metabolic process (GO:0009404)3.24320565
50cellular response to cadmium ion (GO:0071276)3.22929595
51somite development (GO:0061053)3.22580379
52limb bud formation (GO:0060174)3.21592674
53regulation of synapse structural plasticity (GO:0051823)3.21101949
54regulation of synaptic vesicle exocytosis (GO:2000300)3.19850116
55nonmotile primary cilium assembly (GO:0035058)3.16961638
56regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.16160766
57regulation of respiratory system process (GO:0044065)3.16061533
58sequestering of extracellular ligand from receptor (GO:0035581)3.14195530
59cerebral cortex cell migration (GO:0021795)3.13470694
60estrogen biosynthetic process (GO:0006703)3.13130955
61negative regulation of axon guidance (GO:1902668)3.11361219
62cellular response to cholesterol (GO:0071397)3.09809601
63vocalization behavior (GO:0071625)3.09762036
64ionotropic glutamate receptor signaling pathway (GO:0035235)3.09104614
65neuromuscular synaptic transmission (GO:0007274)3.08724417
66regulation of axon guidance (GO:1902667)3.08528812
67synaptic transmission, cholinergic (GO:0007271)3.08307947
68cellular response to interferon-alpha (GO:0035457)3.06678687
69response to auditory stimulus (GO:0010996)3.05350608
70cell proliferation in forebrain (GO:0021846)3.03219645
71central nervous system neuron axonogenesis (GO:0021955)3.03164369
72neuronal ion channel clustering (GO:0045161)3.01284542
73regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.01001314
74epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.99685036
75transmission of nerve impulse (GO:0019226)2.99142019
76positive regulation of neuroblast proliferation (GO:0002052)2.93652258
77camera-type eye morphogenesis (GO:0048593)2.91924376
78tongue development (GO:0043586)2.89531759
79positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.87894684
80neuron fate determination (GO:0048664)2.87642874
81negative regulation of microtubule polymerization (GO:0031115)2.86897042
82regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.86719202
83cell migration in hindbrain (GO:0021535)2.85964326
84neurotransmitter-gated ion channel clustering (GO:0072578)2.84976417
85cell communication involved in cardiac conduction (GO:0086065)2.83649246
86chondrocyte proliferation (GO:0035988)2.82197824
87activation of protein kinase A activity (GO:0034199)2.81284492
88regulation of axon extension involved in axon guidance (GO:0048841)2.81078020
89synaptic transmission, glutamatergic (GO:0035249)2.77922258
90establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.77393600
91mitochondrion transport along microtubule (GO:0047497)2.77393600
92C21-steroid hormone metabolic process (GO:0008207)2.77147139
93protein localization to synapse (GO:0035418)2.76719989
94neuronal action potential propagation (GO:0019227)2.76495669
95neuron migration (GO:0001764)2.76036430
96neurotransmitter secretion (GO:0007269)2.75740963
97dermatan sulfate biosynthetic process (GO:0030208)2.75681325
98central nervous system myelination (GO:0022010)2.75267941
99axon ensheathment in central nervous system (GO:0032291)2.75267941
100negative regulation of transcription regulatory region DNA binding (GO:2000678)2.74894422
101negative regulation of axonogenesis (GO:0050771)2.73294997
102hippocampus development (GO:0021766)2.72999167
103cranial nerve development (GO:0021545)2.72086513
104cell differentiation in spinal cord (GO:0021515)2.71707723
105establishment of nucleus localization (GO:0040023)2.71570500
106negative regulation of axon extension (GO:0030517)2.71137048
107regulation of feeding behavior (GO:0060259)2.70250435
108epithelial cilium movement (GO:0003351)2.69824332
109innervation (GO:0060384)2.69433390
110positive regulation of vesicle fusion (GO:0031340)2.68471320
111regulation of synaptic vesicle transport (GO:1902803)2.68346184
112protein targeting to plasma membrane (GO:0072661)2.67960620
113stress fiber assembly (GO:0043149)2.66810616
114negative regulation of axon extension involved in axon guidance (GO:0048843)2.66239323
115forebrain cell migration (GO:0021885)2.65794126
116telencephalon cell migration (GO:0022029)2.65220096
117locomotory exploration behavior (GO:0035641)2.63979576
118positive regulation of oligodendrocyte differentiation (GO:0048714)2.63923683
119cerebellar Purkinje cell layer development (GO:0021680)2.63566323
120regulation of clathrin-mediated endocytosis (GO:2000369)2.63516606
121astrocyte differentiation (GO:0048708)2.63339094
122intraciliary transport (GO:0042073)2.62228516
123negative regulation of oligodendrocyte differentiation (GO:0048715)2.61844237
124positive regulation of male gonad development (GO:2000020)2.61702713
125regulation of glutamate receptor signaling pathway (GO:1900449)2.61364908
126positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.60369887
127cytoskeletal anchoring at plasma membrane (GO:0007016)2.60006858
128synapse organization (GO:0050808)2.59632929
129regulation of vesicle fusion (GO:0031338)2.59486647
130detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.59294740
131detection of temperature stimulus involved in sensory perception (GO:0050961)2.59294740
132peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.59066360
133positive regulation of neural precursor cell proliferation (GO:2000179)2.58651035
134axon extension (GO:0048675)2.56077192
135prepulse inhibition (GO:0060134)2.55418868
136dendrite morphogenesis (GO:0048813)2.55204542
137neuron recognition (GO:0008038)2.53099221
138regulation of growth hormone secretion (GO:0060123)2.52769401
139proline transport (GO:0015824)2.51911144
140axon cargo transport (GO:0008088)2.51683866
141regulation of respiratory gaseous exchange (GO:0043576)2.50822983
142regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.50486243
143positive regulation of axon extension (GO:0045773)2.50090405
144regulation of timing of cell differentiation (GO:0048505)2.49945066
145regulation of development, heterochronic (GO:0040034)2.49132843
146hindbrain development (GO:0030902)2.49061157
147regulation of tight junction assembly (GO:2000810)2.48224616
148positive regulation of potassium ion transmembrane transport (GO:1901381)2.48046549
149axon extension involved in axon guidance (GO:0048846)2.46797029
150neuron projection extension involved in neuron projection guidance (GO:1902284)2.46797029
151positive regulation of synapse maturation (GO:0090129)2.44639871
152regulation of voltage-gated calcium channel activity (GO:1901385)2.44398420
153exploration behavior (GO:0035640)2.43315558
154negative regulation of fatty acid transport (GO:2000192)2.42514831
155positive regulation of fibroblast migration (GO:0010763)2.40915975
156positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.39178915
157negative regulation of synaptic transmission, GABAergic (GO:0032229)2.37882631
158cellular sodium ion homeostasis (GO:0006883)2.37821389
159cell adhesion mediated by integrin (GO:0033627)2.37436788
160neurotransmitter transport (GO:0006836)2.37000073
161regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.36810241
162collagen fibril organization (GO:0030199)2.35929690
163cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.35529437
164membrane repolarization (GO:0086009)2.35397128
165neuron cell-cell adhesion (GO:0007158)2.34430246
166negative regulation of cation channel activity (GO:2001258)2.34158407
167negative regulation of calcium ion transmembrane transport (GO:1903170)2.33845333
168negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.33845333
169positive regulation of potassium ion transport (GO:0043268)2.33592472
170axonal fasciculation (GO:0007413)2.32859156
171regulation of cell communication by electrical coupling (GO:0010649)2.32781976
172neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.32412313
173positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.31431254
174regulation of neuronal synaptic plasticity (GO:0048168)2.30054813
175renal system process involved in regulation of blood volume (GO:0001977)2.30021261
176metanephric mesenchyme development (GO:0072075)2.29532955
177regulation of calcium ion transmembrane transport (GO:1903169)2.28132257
178regulation of calcium ion transmembrane transporter activity (GO:1901019)2.28132257
179sodium ion homeostasis (GO:0055078)2.27113169
180detection of temperature stimulus (GO:0016048)2.26977889
181androgen biosynthetic process (GO:0006702)2.25386687
182dendritic spine morphogenesis (GO:0060997)2.25247095
183synaptic vesicle endocytosis (GO:0048488)2.23894055
184heparan sulfate proteoglycan metabolic process (GO:0030201)2.23727413

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.03501388
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.31958953
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92363572
4* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76146790
5* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76146790
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.65684361
7* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64866272
8EZH2_22144423_ChIP-Seq_EOC_Human2.59893141
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.58945310
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.58591933
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.52561366
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41768823
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.39223400
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37032056
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.36280111
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35366942
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33949227
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32618638
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.21173369
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05429183
21RNF2_27304074_Chip-Seq_NSC_Mouse1.99295400
22IGF1R_20145208_ChIP-Seq_DFB_Human1.99032140
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96507940
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.96026039
25GBX2_23144817_ChIP-Seq_PC3_Human1.93221726
26DROSHA_22980978_ChIP-Seq_HELA_Human1.93085427
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87986590
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85776029
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80554785
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.72425507
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71212669
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66081087
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65451954
34POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.65451954
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.64744767
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64426655
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.62138847
38TAF15_26573619_Chip-Seq_HEK293_Human1.58487133
39EP300_21415370_ChIP-Seq_HL-1_Mouse1.56980768
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.56801128
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54930164
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.54033974
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51560114
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51379967
45* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.50042164
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47494567
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.45739961
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.45280219
49KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.44874867
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44343071
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43800990
52* REST_21632747_ChIP-Seq_MESCs_Mouse1.42306839
53TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41388785
54RARB_27405468_Chip-Seq_BRAIN_Mouse1.40758974
55* KDM2B_26808549_Chip-Seq_K562_Human1.37023163
56REST_18959480_ChIP-ChIP_MESCs_Mouse1.36990589
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36763220
58* RING1B_27294783_Chip-Seq_ESCs_Mouse1.36634987
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36469160
60AR_21572438_ChIP-Seq_LNCaP_Human1.34464611
61FUS_26573619_Chip-Seq_HEK293_Human1.33109307
62CLOCK_20551151_ChIP-Seq_293T_Human1.32030619
63RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.31827125
64P300_19829295_ChIP-Seq_ESCs_Human1.30368296
65ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29406507
66EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28791625
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27556346
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27381390
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.26123295
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26029832
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25409405
72* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25214182
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24409370
74* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23964244
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23880566
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.19818379
77* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19499171
78ZNF274_21170338_ChIP-Seq_K562_Hela1.18956080
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.18055489
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17554296
81RING1B_27294783_Chip-Seq_NPCs_Mouse1.16497872
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15912704
83LXR_22292898_ChIP-Seq_THP-1_Human1.14419483
84PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14208612
85* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14132545
86SOX2_16153702_ChIP-ChIP_HESCs_Human1.12281383
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11687609
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10614974
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08913888
90ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08839567
91TP53_18474530_ChIP-ChIP_U2OS_Human1.08613024
92* CJUN_26792858_Chip-Seq_BT549_Human1.08368414
93* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07907024
94EWS_26573619_Chip-Seq_HEK293_Human1.07754936
95BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07276893
96CTCF_27219007_Chip-Seq_Bcells_Human1.07170408
97GATA1_26923725_Chip-Seq_HPCs_Mouse1.06921806
98P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05960764
99KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04907119
100CBX2_27304074_Chip-Seq_ESCs_Mouse1.03427382
101ISL1_27105846_Chip-Seq_CPCs_Mouse1.03342382
102OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03173473
103TP53_23651856_ChIP-Seq_MEFs_Mouse1.03067623
104IRF1_19129219_ChIP-ChIP_H3396_Human1.02336194
105* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02019297
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01806739
107AHR_22903824_ChIP-Seq_MCF-7_Human1.00910100
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00598355
109POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00472747
110SMAD4_21799915_ChIP-Seq_A2780_Human0.99177587
111SOX9_26525672_Chip-Seq_HEART_Mouse0.98232288
112AR_25329375_ChIP-Seq_VCAP_Human0.98231358
113NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98097247
114SMAD4_21741376_ChIP-Seq_HESCs_Human0.97880903
115TP63_19390658_ChIP-ChIP_HaCaT_Human0.97827515
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97786834
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97571871
118* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97091809
119* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96994441
120* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96994441
121* AR_19668381_ChIP-Seq_PC3_Human0.96830725
122RUNX2_22187159_ChIP-Seq_PCA_Human0.95295590
123TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95198977
124MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95001705
125* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94923811
126CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94904166
127UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94837572
128STAT3_23295773_ChIP-Seq_U87_Human0.93948699
129TET1_21490601_ChIP-Seq_MESCs_Mouse0.93247695
130PIAS1_25552417_ChIP-Seq_VCAP_Human0.93040945
131SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92354491
132* NANOG_18555785_Chip-Seq_ESCs_Mouse0.91255427
133ESR1_20079471_ChIP-ChIP_T-47D_Human0.91244488
134* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91195219
135ARNT_22903824_ChIP-Seq_MCF-7_Human0.91116058
136SMAD3_21741376_ChIP-Seq_ESCs_Human0.91024462
137SOX2_21211035_ChIP-Seq_LN229_Gbm0.90833403
138SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.90532727
139SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89797724
140UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89783723
141SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89522051
142SMAD3_21741376_ChIP-Seq_HESCs_Human0.87569825
143TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87030208
144ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86846341
145CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.84303125
146ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83765148
147TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81650669
148SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80286318
149TP53_16413492_ChIP-PET_HCT116_Human0.79480372
150TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.78914453
151YAP1_20516196_ChIP-Seq_MESCs_Mouse0.78134272

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.07393771
2MP0002653_abnormal_ependyma_morphology3.07169642
3MP0003880_abnormal_central_pattern3.03914010
4MP0005623_abnormal_meninges_morphology3.03197724
5MP0008438_abnormal_cutaneous_collagen2.79140835
6MP0001529_abnormal_vocalization2.68927675
7MP0000751_myopathy2.52606179
8MP0002909_abnormal_adrenal_gland2.43104853
9MP0006292_abnormal_olfactory_placode2.39294185
10MP0010030_abnormal_orbit_morphology2.35006907
11MP0008789_abnormal_olfactory_epithelium2.27506202
12MP0005499_abnormal_olfactory_system2.27433012
13MP0005394_taste/olfaction_phenotype2.27433012
14MP0003635_abnormal_synaptic_transmissio2.17772028
15MP0004084_abnormal_cardiac_muscle2.17700088
16MP0003787_abnormal_imprinting2.16126433
17MP0005503_abnormal_tendon_morphology2.13373989
18MP0002638_abnormal_pupillary_reflex2.12784329
19MP0003279_aneurysm2.11675177
20MP0003705_abnormal_hypodermis_morpholog2.05289160
21MP0003136_yellow_coat_color2.00968764
22MP0000013_abnormal_adipose_tissue1.94497430
23MP0005551_abnormal_eye_electrophysiolog1.93248592
24MP0004885_abnormal_endolymph1.91344464
25MP0004233_abnormal_muscle_weight1.91033589
26MP0002837_dystrophic_cardiac_calcinosis1.90270844
27MP0003121_genomic_imprinting1.84550874
28MP0001958_emphysema1.84111461
29MP0009379_abnormal_foot_pigmentation1.76039304
30MP0000566_synostosis1.74268400
31MP0004133_heterotaxia1.72849082
32MP0001968_abnormal_touch/_nociception1.72397288
33MP0001299_abnormal_eye_distance/1.70856385
34MP0005275_abnormal_skin_tensile1.70685597
35MP0003283_abnormal_digestive_organ1.70537786
36MP0005423_abnormal_somatic_nervous1.67856509
37MP0009780_abnormal_chondrocyte_physiolo1.65520329
38MP0000049_abnormal_middle_ear1.65486306
39MP0002734_abnormal_mechanical_nocicepti1.64311308
40MP0004270_analgesia1.63726491
41MP0000631_abnormal_neuroendocrine_gland1.63102859
42MP0006276_abnormal_autonomic_nervous1.62853963
43MP0001348_abnormal_lacrimal_gland1.55143618
44MP0002063_abnormal_learning/memory/cond1.55139487
45MP0003123_paternal_imprinting1.55116576
46MP0003890_abnormal_embryonic-extraembry1.53577610
47MP0002090_abnormal_vision1.53555136
48MP0003329_amyloid_beta_deposits1.53168164
49MP0002751_abnormal_autonomic_nervous1.47066433
50MP0002064_seizures1.45953952
51MP0000534_abnormal_ureter_morphology1.42815763
52MP0005253_abnormal_eye_physiology1.42545424
53MP0002735_abnormal_chemical_nociception1.42242532
54MP0006072_abnormal_retinal_apoptosis1.41544136
55MP0004036_abnormal_muscle_relaxation1.40422517
56MP0009745_abnormal_behavioral_response1.39232429
57MP0002152_abnormal_brain_morphology1.39049758
58MP0000749_muscle_degeneration1.37273106
59MP0004215_abnormal_myocardial_fiber1.36594585
60MP0002736_abnormal_nociception_after1.35968902
61MP0003942_abnormal_urinary_system1.35966605
62MP0009046_muscle_twitch1.35838962
63MP0003861_abnormal_nervous_system1.35656217
64MP0004142_abnormal_muscle_tone1.35265333
65MP0002184_abnormal_innervation1.33714752
66MP0003091_abnormal_cell_migration1.33542196
67MP0003011_delayed_dark_adaptation1.32966221
68MP0004858_abnormal_nervous_system1.31383667
69MP0002272_abnormal_nervous_system1.29067402
70MP0008775_abnormal_heart_ventricle1.28253520
71MP0005645_abnormal_hypothalamus_physiol1.27046248
72MP0002233_abnormal_nose_morphology1.25742541
73MP0001970_abnormal_pain_threshold1.25530600
74MP0000026_abnormal_inner_ear1.23484012
75MP0001440_abnormal_grooming_behavior1.22416039
76MP0002249_abnormal_larynx_morphology1.22249063
77MP0001905_abnormal_dopamine_level1.22075075
78MP0002733_abnormal_thermal_nociception1.21399355
79MP0002572_abnormal_emotion/affect_behav1.21376880
80MP0000639_abnormal_adrenal_gland1.19243733
81MP0001293_anophthalmia1.17636410
82MP0004085_abnormal_heartbeat1.17360242
83MP0002234_abnormal_pharynx_morphology1.16987271
84MP0000778_abnormal_nervous_system1.16619616
85MP0004087_abnormal_muscle_fiber1.15886633
86MP0002089_abnormal_postnatal_growth/wei1.15499329
87MP0001485_abnormal_pinna_reflex1.15086979
88MP0004272_abnormal_basement_membrane1.14639592
89MP0005248_abnormal_Harderian_gland1.14090822
90MP0003938_abnormal_ear_development1.13938886
91MP0005391_vision/eye_phenotype1.13545405
92MP0000747_muscle_weakness1.13313198
93MP0003137_abnormal_impulse_conducting1.12954639
94MP0003937_abnormal_limbs/digits/tail_de1.12718448
95MP0001346_abnormal_lacrimal_gland1.12622716
96MP0002938_white_spotting1.11318525
97MP0001486_abnormal_startle_reflex1.09676542
98MP0002067_abnormal_sensory_capabilities1.09639871
99MP0004742_abnormal_vestibular_system1.08173582
100MP0002102_abnormal_ear_morphology1.07642392
101MP0009250_abnormal_appendicular_skeleto1.07138102
102MP0005620_abnormal_muscle_contractility1.06416889
103MP0010368_abnormal_lymphatic_system1.05289066
104MP0005330_cardiomyopathy1.04499101
105MP0003755_abnormal_palate_morphology1.04377874
106MP0002882_abnormal_neuron_morphology1.02720861
107MP0004811_abnormal_neuron_physiology1.02674464
108MP0003566_abnormal_cell_adhesion1.02242139
109MP0005646_abnormal_pituitary_gland1.01802483
110MP0001984_abnormal_olfaction1.00914213
111MP0001286_abnormal_eye_development1.00711330
112MP0002972_abnormal_cardiac_muscle1.00266908
113MP0003122_maternal_imprinting0.99990430
114MP0001502_abnormal_circadian_rhythm0.99945413
115MP0000750_abnormal_muscle_regeneration0.99761634
116MP0000955_abnormal_spinal_cord0.99336964
117MP0003385_abnormal_body_wall0.99244831
118MP0000759_abnormal_skeletal_muscle0.98252853
119MP0002269_muscular_atrophy0.97625350
120MP0005595_abnormal_vascular_smooth0.97469054
121MP0002697_abnormal_eye_size0.97327569
122MP0002108_abnormal_muscle_morphology0.96814907
123MP0003119_abnormal_digestive_system0.95536059
124MP0005187_abnormal_penis_morphology0.91339097
125MP0002295_abnormal_pulmonary_circulatio0.90963105
126MP0000230_abnormal_systemic_arterial0.90103551
127MP0004924_abnormal_behavior0.88268451
128MP0005386_behavior/neurological_phenoty0.88268451
129MP0001963_abnormal_hearing_physiology0.88217490
130MP0009384_cardiac_valve_regurgitation0.87861830
131MP0000003_abnormal_adipose_tissue0.87817107
132MP0004145_abnormal_muscle_electrophysio0.87654190
133MP0002066_abnormal_motor_capabilities/c0.86082472
134MP0002896_abnormal_bone_mineralization0.86054648
135MP0002557_abnormal_social/conspecific_i0.84461596
136MP0010386_abnormal_urinary_bladder0.83113788
137MP0002116_abnormal_craniofacial_bone0.82961258
138MP0004484_altered_response_of0.82917383
139MP0002092_abnormal_eye_morphology0.82444714
140MP0001501_abnormal_sleep_pattern0.82323194
141MP0001188_hyperpigmentation0.81009304
142MP0001177_atelectasis0.80720264
143MP0008995_early_reproductive_senescence0.79604496
144MP0008569_lethality_at_weaning0.79592989
145MP0002069_abnormal_eating/drinking_beha0.78469458
146MP0006138_congestive_heart_failure0.78462999
147MP0002095_abnormal_skin_pigmentation0.77528797
148MP0003879_abnormal_hair_cell0.76966411
149MP0005195_abnormal_posterior_eye0.76785521
150MP0000569_abnormal_digit_pigmentation0.76043842
151MP0002081_perinatal_lethality0.75960714
152MP0008961_abnormal_basal_metabolism0.74796167
153MP0002822_catalepsy0.74662343
154MP0002752_abnormal_somatic_nervous0.74248622

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.07813460
2Premature rupture of membranes (HP:0001788)4.89460327
3Abnormal gallbladder physiology (HP:0012438)3.60607644
4Cholecystitis (HP:0001082)3.60607644
5Hepatoblastoma (HP:0002884)3.53912355
6Congenital stationary night blindness (HP:0007642)3.38293994
7True hermaphroditism (HP:0010459)3.23470804
8Septo-optic dysplasia (HP:0100842)3.20386038
9Central scotoma (HP:0000603)3.05849339
10Anomalous pulmonary venous return (HP:0010772)3.05281743
11Rib fusion (HP:0000902)3.03169118
12Oligodactyly (hands) (HP:0001180)3.01501898
13Abnormality of the diencephalon (HP:0010662)3.00560290
14Gait imbalance (HP:0002141)2.99126873
15Intestinal atresia (HP:0011100)2.98530393
16Abnormality of dentin (HP:0010299)2.94009998
17Short 4th metacarpal (HP:0010044)2.92916003
18Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.92916003
19Enlarged penis (HP:0000040)2.91385587
20Retinal dysplasia (HP:0007973)2.91078523
21Shallow orbits (HP:0000586)2.86704346
22Cortical dysplasia (HP:0002539)2.86596821
23Myokymia (HP:0002411)2.76776936
24Medial flaring of the eyebrow (HP:0010747)2.72339876
25Abnormality of the 4th metacarpal (HP:0010012)2.70466778
26Focal motor seizures (HP:0011153)2.67471796
27Distal upper limb amyotrophy (HP:0007149)2.67259871
28Upper limb amyotrophy (HP:0009129)2.67259871
29Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.66807085
30Oligodactyly (HP:0012165)2.64447605
31Renal salt wasting (HP:0000127)2.62969678
32Congenital primary aphakia (HP:0007707)2.61903687
33Hemiparesis (HP:0001269)2.61283142
34Atrophic scars (HP:0001075)2.59692563
35Difficulty climbing stairs (HP:0003551)2.57184866
36Abnormality of midbrain morphology (HP:0002418)2.55643414
37Molar tooth sign on MRI (HP:0002419)2.55643414
38Abnormality of the pulmonary veins (HP:0011718)2.54951791
39Increased connective tissue (HP:0009025)2.53206800
40Nephrogenic diabetes insipidus (HP:0009806)2.51760197
41Nephronophthisis (HP:0000090)2.49326930
42Bladder diverticulum (HP:0000015)2.49294480
43Hemivertebrae (HP:0002937)2.48899499
44Drooling (HP:0002307)2.48780288
45Hypoventilation (HP:0002791)2.47973497
46Fragile skin (HP:0001030)2.47576713
47Increased circulating renin level (HP:0000848)2.47297283
48Optic nerve hypoplasia (HP:0000609)2.46289885
49Morphological abnormality of the middle ear (HP:0008609)2.46213505
50Anophthalmia (HP:0000528)2.45707274
51Pancreatic fibrosis (HP:0100732)2.44840492
52Split foot (HP:0001839)2.44505371
53Dilatation of the ascending aorta (HP:0005111)2.42862125
54Cerebral aneurysm (HP:0004944)2.42456036
55Visual hallucinations (HP:0002367)2.41917262
56Peritonitis (HP:0002586)2.40900094
57Lissencephaly (HP:0001339)2.40438333
58Renal hypoplasia (HP:0000089)2.40058507
59Aortic dissection (HP:0002647)2.38628365
60Pachygyria (HP:0001302)2.36418741
61Abnormality of macular pigmentation (HP:0008002)2.35986443
62Bowel diverticulosis (HP:0005222)2.35899005
63Muscle fiber splitting (HP:0003555)2.35076924
64Lower limb amyotrophy (HP:0007210)2.33449924
65Broad metatarsal (HP:0001783)2.32842869
66Prolonged QT interval (HP:0001657)2.31963720
67Hand muscle atrophy (HP:0009130)2.31760442
68Specific learning disability (HP:0001328)2.31671376
69Chronic hepatic failure (HP:0100626)2.31240666
70Neonatal short-limb short stature (HP:0008921)2.30113386
71Hypercortisolism (HP:0001578)2.28823744
72Sudden death (HP:0001699)2.26793856
73Atrial fibrillation (HP:0005110)2.26434602
74Excessive salivation (HP:0003781)2.25374411
75Scotoma (HP:0000575)2.24779245
76Primary atrial arrhythmia (HP:0001692)2.22818488
77Peripheral hypomyelination (HP:0007182)2.22812916
78Buphthalmos (HP:0000557)2.21952771
79Pancreatic cysts (HP:0001737)2.21171354
80Polyphagia (HP:0002591)2.19534857
81Long toe (HP:0010511)2.19451466
82Focal seizures (HP:0007359)2.19334542
83Wrist flexion contracture (HP:0001239)2.18881566
84Spinal rigidity (HP:0003306)2.18759183
85Achilles tendon contracture (HP:0001771)2.18082379
86Abnormality of the aortic arch (HP:0012303)2.15767427
87Adrenal overactivity (HP:0002717)2.15109462
88Supranuclear gaze palsy (HP:0000605)2.15039764
89Supraventricular arrhythmia (HP:0005115)2.14803459
90Progressive cerebellar ataxia (HP:0002073)2.13955813
91Vaginal atresia (HP:0000148)2.13709885
92Supraventricular tachycardia (HP:0004755)2.13357627
93Limb dystonia (HP:0002451)2.12802132
94Aplasia/Hypoplasia of the sternum (HP:0006714)2.11819518
95Short nail (HP:0001799)2.11570703
96Congenital glaucoma (HP:0001087)2.11043808
97Genital tract atresia (HP:0001827)2.10930745
98Abnormality of the lower motor neuron (HP:0002366)2.10453054
99Postaxial hand polydactyly (HP:0001162)2.10445271
100Sclerocornea (HP:0000647)2.09998377
101Abnormality of the renal medulla (HP:0100957)2.09611038
102Increased variability in muscle fiber diameter (HP:0003557)2.09106023
103Poor coordination (HP:0002370)2.07981863
104Aortic aneurysm (HP:0004942)2.07041880
105Aplasia involving bones of the upper limbs (HP:0009823)2.06946098
106Aplasia of the phalanges of the hand (HP:0009802)2.06946098
107Aplasia involving bones of the extremities (HP:0009825)2.06946098
108Overgrowth (HP:0001548)2.06232803
109Abnormality of the calf musculature (HP:0001430)2.05216213
110Neonatal onset (HP:0003623)2.04683775
111Hyperventilation (HP:0002883)2.04617261
112Cholelithiasis (HP:0001081)2.04206829
113Distal lower limb amyotrophy (HP:0008944)2.03168379
114Type II lissencephaly (HP:0007260)2.02854530
115Gastrointestinal atresia (HP:0002589)2.02629132
116Abnormality of the intervertebral disk (HP:0005108)2.01951005
117Myotonia (HP:0002486)2.01872175
118Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.01406866
119Hyperaldosteronism (HP:0000859)2.01395180
120Genu recurvatum (HP:0002816)2.00479027
121Renal dysplasia (HP:0000110)1.99954388
122Wormian bones (HP:0002645)1.99301793
123Abnormality of the Achilles tendon (HP:0005109)1.99274350
124Esophageal atresia (HP:0002032)1.98937372
125Vitreoretinal degeneration (HP:0000655)1.98207459
126Depression (HP:0000716)1.97764697
127Soft skin (HP:0000977)1.97404043
128Growth hormone deficiency (HP:0000824)1.97229655
129Agitation (HP:0000713)1.97226804
130Abnormality of renin-angiotensin system (HP:0000847)1.96695936
131Hypoplasia of the brainstem (HP:0002365)1.96628725
132Aplasia/Hypoplasia of the brainstem (HP:0007362)1.96628725
133Anencephaly (HP:0002323)1.93555249
134Decreased circulating renin level (HP:0003351)1.92672304
135Bronchomalacia (HP:0002780)1.92306180
136Ankle contracture (HP:0006466)1.91382816
137Limb-girdle muscle atrophy (HP:0003797)1.90705102
138Severe visual impairment (HP:0001141)1.89914392
139Pheochromocytoma (HP:0002666)1.89466236
140Abnormality of the antihelix (HP:0009738)1.89388284
141Epileptic encephalopathy (HP:0200134)1.89225358
142Occipital encephalocele (HP:0002085)1.86799347
143Hyporeflexia of lower limbs (HP:0002600)1.86238083
144Amyotrophic lateral sclerosis (HP:0007354)1.85166933
145Micropenis (HP:0000054)1.84191665
146Preaxial hand polydactyly (HP:0001177)1.83889257
147Action tremor (HP:0002345)1.83561893
148Postaxial foot polydactyly (HP:0001830)1.82407930
149Spinal cord compression (HP:0002176)1.81790056
150Supernumerary spleens (HP:0009799)1.81783306
151Bradycardia (HP:0001662)1.81184098
152Cutaneous finger syndactyly (HP:0010554)1.79981974
153Hyperglycinemia (HP:0002154)1.79771290
154Vertebral compression fractures (HP:0002953)1.79576300
155Mitral valve prolapse (HP:0001634)1.79322237
156Amblyopia (HP:0000646)1.79086272
157Scapular winging (HP:0003691)1.78739545
158Absence seizures (HP:0002121)1.78107858
159Polymicrogyria (HP:0002126)1.77851585
160Rapidly progressive (HP:0003678)1.77726247
161Megalencephaly (HP:0001355)1.76168428
162EMG: myopathic abnormalities (HP:0003458)1.76160906
163Absent septum pellucidum (HP:0001331)1.74925604
164Abnormality of the labia minora (HP:0012880)1.74896148
165Increased corneal curvature (HP:0100692)1.74748705
166Keratoconus (HP:0000563)1.74748705
167Fibular hypoplasia (HP:0003038)1.74662227
168Double outlet right ventricle (HP:0001719)1.74128198
169Congenital malformation of the right heart (HP:0011723)1.74128198
170Absent speech (HP:0001344)1.73204285
171Vascular tortuosity (HP:0004948)1.73067668
172Abnormal gallbladder morphology (HP:0012437)1.72897523
173Neoplasm of the adrenal cortex (HP:0100641)1.72845541
174Decreased testicular size (HP:0008734)1.70215122
175Right ventricular cardiomyopathy (HP:0011663)1.70095806
176Elfin facies (HP:0004428)1.69910361
177Pendular nystagmus (HP:0012043)1.69398912
178Hyperextensible skin (HP:0000974)1.69102800
179Hypoplasia of the corpus callosum (HP:0002079)1.68976255
180Cystic liver disease (HP:0006706)1.68433568
181Male pseudohermaphroditism (HP:0000037)1.68123074
182Testicular neoplasm (HP:0010788)1.68089150
183Infantile muscular hypotonia (HP:0008947)1.67750766
184Narrow forehead (HP:0000341)1.67337254
185Cerebellar dysplasia (HP:0007033)1.66363348
186Febrile seizures (HP:0002373)1.65770575
187Ventricular fibrillation (HP:0001663)1.65660415
188Colon cancer (HP:0003003)1.65577739
189Exotropia (HP:0000577)1.65324345
190Holoprosencephaly (HP:0001360)1.63132503
191Cutaneous syndactyly (HP:0012725)1.61627951
192Renovascular hypertension (HP:0100817)1.60397025
193Meningocele (HP:0002435)1.60286212
194Volvulus (HP:0002580)1.59352864
195Spastic tetraplegia (HP:0002510)1.59289721
196Maternal diabetes (HP:0009800)1.58981712

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.44976388
2TRIB33.36401635
3TTN3.23979075
4LATS23.16828808
5DYRK22.81379785
6PAK62.67880508
7MARK12.49303287
8LIMK12.48289265
9MINK12.39780976
10TNIK2.35240388
11PAK32.30400846
12PNCK2.29231665
13PTK2B2.15588371
14PKN22.09789862
15BCR2.06925719
16TYRO31.98574808
17DDR21.88652440
18PHKG21.87768776
19PHKG11.87768776
20TESK11.79385267
21CSNK1G21.74197934
22NEK11.71867471
23MAP3K41.69289839
24KSR21.64859178
25NTRK11.64596175
26MAP3K91.63324573
27LMTK21.60815865
28FER1.59907939
29BMPR1B1.59161191
30MAPK151.58222307
31NTRK31.54239152
32EPHA31.53494831
33RIPK11.46934246
34STK381.44977193
35EPHB21.42050665
36MAP4K21.40718430
37CAMKK11.40583574
38PTK21.40334464
39CSNK1G31.38925339
40MKNK21.35597263
41WNK41.33641653
42PDGFRA1.33133719
43CSNK1G11.30554723
44RET1.29563961
45DYRK31.22845958
46CSNK1A1L1.21734374
47CDK141.19300469
48PKN11.18038450
49TESK21.15737824
50MAP2K11.15608789
51ROCK11.14903247
52GRK51.13458003
53MKNK11.12323953
54CDK151.11685137
55PRKD31.11430939
56FGFR21.10748545
57CDK181.08657786
58CDC42BPA1.07383373
59SGK4941.05681823
60SGK2231.05681823
61ROCK21.04599999
62DMPK1.03913410
63ERBB31.03710697
64ERBB21.02009472
65TRIM281.00834757
66WNK11.00204899
67MYLK0.99562842
68PLK20.97944710
69CDK11A0.97417992
70BMX0.97145877
71CAMK2D0.95476863
72PAK20.95211950
73PINK10.94872228
74CDK50.94491720
75ERBB40.92352395
76TAOK10.90446746
77UHMK10.90012813
78CAMK2A0.89809628
79CAMK1G0.89629957
80CDK190.87897314
81MAP3K20.85605451
82SIK20.85239059
83MAP2K40.85213886
84MAP2K70.84172082
85PRKD10.83459467
86SGK20.80532295
87ADRBK20.75576649
88NTRK20.75466641
89DAPK30.74682861
90PTK60.74525036
91MAPKAPK50.73232303
92DAPK20.71576252
93ILK0.71017657
94TLK10.70171489
95MAPK130.68676592
96CAMK1D0.67786589
97MAP3K70.66644192
98FGFR10.66132160
99PRKCG0.64052233
100STK390.63880224
101PRKCH0.63790197
102PRKG20.61655168
103KSR10.60571080
104SCYL20.59140221
105MARK20.58526013
106BCKDK0.57999532
107TNK20.57351723
108EPHA40.56652357
109SIK10.56498699
110ERN10.55286811
111PDK40.55043670
112PDK30.55043670
113DYRK1B0.54804298
114ADRBK10.54115828
115MOS0.52987769
116LRRK20.52914506
117CAMKK20.52631032
118DYRK1A0.51591674
119WEE10.49661813
120CDK30.49277570
121PRKCE0.48567301
122OXSR10.48270063
123STK110.48220312
124CAMK2G0.47672076
125STK38L0.47436407
126CSNK1D0.46966179
127FRK0.46952119
128PRKAA10.46815894
129WNK30.46608587
130PRKD20.46098201
131PRKACA0.45880040
132CAMK10.45403551
133RPS6KA20.45274483
134PRKCZ0.44005412
135SGK10.43718886
136CAMK2B0.43640290
137PIK3CA0.43302346
138CAMK40.39906212
139GRK10.39609968
140PRKDC0.37603158
141MAP3K100.36239958
142NUAK10.34980250
143CSNK1A10.33547510
144CSNK1E0.33430892
145INSRR0.33255281
146RPS6KA50.30357751
147GSK3B0.29947025
148PRKG10.29666751
149SRPK10.29602912
150PRKACG0.29298917
151PRKACB0.29144525

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.91338157
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.34389283
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.29159637
4Nicotine addiction_Homo sapiens_hsa050332.15965867
5Basal cell carcinoma_Homo sapiens_hsa052172.13399559
6Aldosterone synthesis and secretion_Homo sapiens_hsa049252.12919448
7Notch signaling pathway_Homo sapiens_hsa043302.10898214
8Cardiac muscle contraction_Homo sapiens_hsa042602.02718157
9GABAergic synapse_Homo sapiens_hsa047271.92765552
10Hedgehog signaling pathway_Homo sapiens_hsa043401.92662844
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.90580609
12Dilated cardiomyopathy_Homo sapiens_hsa054141.88557169
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.87988129
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.86018618
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.73794270
16Steroid biosynthesis_Homo sapiens_hsa001001.72361273
17Circadian entrainment_Homo sapiens_hsa047131.69966974
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.67348380
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.65572519
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.65426646
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.61074552
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59542875
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.58074409
24Insulin secretion_Homo sapiens_hsa049111.51671950
25Morphine addiction_Homo sapiens_hsa050321.51471927
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44933014
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44179402
28Phototransduction_Homo sapiens_hsa047441.43467313
29Dopaminergic synapse_Homo sapiens_hsa047281.43206334
30Olfactory transduction_Homo sapiens_hsa047401.38990576
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38124530
32Cholinergic synapse_Homo sapiens_hsa047251.38061242
33Salivary secretion_Homo sapiens_hsa049701.38018889
34Gap junction_Homo sapiens_hsa045401.31186685
35Cocaine addiction_Homo sapiens_hsa050301.28932879
36Glutamatergic synapse_Homo sapiens_hsa047241.24628616
37Oxytocin signaling pathway_Homo sapiens_hsa049211.22550554
38Collecting duct acid secretion_Homo sapiens_hsa049661.22241545
39Gastric acid secretion_Homo sapiens_hsa049711.21920758
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21367247
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20667654
42Amphetamine addiction_Homo sapiens_hsa050311.19749557
43Protein export_Homo sapiens_hsa030601.16442184
44Renin secretion_Homo sapiens_hsa049241.15954330
45Taste transduction_Homo sapiens_hsa047421.13838489
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11218466
47Serotonergic synapse_Homo sapiens_hsa047261.10362886
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10343663
49Ovarian steroidogenesis_Homo sapiens_hsa049131.08670074
50Long-term potentiation_Homo sapiens_hsa047201.04886847
51Vibrio cholerae infection_Homo sapiens_hsa051101.04407860
52ECM-receptor interaction_Homo sapiens_hsa045121.03706168
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.03692170
54Central carbon metabolism in cancer_Homo sapiens_hsa052301.03481687
55Focal adhesion_Homo sapiens_hsa045101.03143694
56Axon guidance_Homo sapiens_hsa043601.02709070
57Parkinsons disease_Homo sapiens_hsa050121.01683963
58GnRH signaling pathway_Homo sapiens_hsa049120.99506766
59Nitrogen metabolism_Homo sapiens_hsa009100.97247844
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96903788
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95396869
62Glioma_Homo sapiens_hsa052140.94968200
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92722279
64Oxidative phosphorylation_Homo sapiens_hsa001900.90874267
65Wnt signaling pathway_Homo sapiens_hsa043100.90208276
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88082550
67Bladder cancer_Homo sapiens_hsa052190.87784419
68Regulation of autophagy_Homo sapiens_hsa041400.87351141
69Propanoate metabolism_Homo sapiens_hsa006400.87132950
70Dorso-ventral axis formation_Homo sapiens_hsa043200.86908263
71Bile secretion_Homo sapiens_hsa049760.86720790
72cAMP signaling pathway_Homo sapiens_hsa040240.85807537
73Alcoholism_Homo sapiens_hsa050340.84906620
74Type II diabetes mellitus_Homo sapiens_hsa049300.84020227
75Estrogen signaling pathway_Homo sapiens_hsa049150.83424526
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83055271
77Fatty acid metabolism_Homo sapiens_hsa012120.81969182
78Alzheimers disease_Homo sapiens_hsa050100.79791856
79Fanconi anemia pathway_Homo sapiens_hsa034600.79594581
80Long-term depression_Homo sapiens_hsa047300.79529324
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.78621111
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78023576
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75350353
84Colorectal cancer_Homo sapiens_hsa052100.74398475
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73357233
86Calcium signaling pathway_Homo sapiens_hsa040200.72570286
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71271086
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71017839
89Proteoglycans in cancer_Homo sapiens_hsa052050.70111698
90Fructose and mannose metabolism_Homo sapiens_hsa000510.69315776
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.69053627
92Basal transcription factors_Homo sapiens_hsa030220.67911930
93Galactose metabolism_Homo sapiens_hsa000520.66572489
94Carbon metabolism_Homo sapiens_hsa012000.66507833
95Melanogenesis_Homo sapiens_hsa049160.66398250
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65746159
97Renal cell carcinoma_Homo sapiens_hsa052110.65476550
98Protein digestion and absorption_Homo sapiens_hsa049740.63899500
99ErbB signaling pathway_Homo sapiens_hsa040120.63536343
100Melanoma_Homo sapiens_hsa052180.61842885
101Linoleic acid metabolism_Homo sapiens_hsa005910.61611004
102Rap1 signaling pathway_Homo sapiens_hsa040150.61538186
103Thyroid hormone synthesis_Homo sapiens_hsa049180.61533537
104Amoebiasis_Homo sapiens_hsa051460.59631800
105Lysine degradation_Homo sapiens_hsa003100.59395017
106Hippo signaling pathway_Homo sapiens_hsa043900.59253573
107Insulin signaling pathway_Homo sapiens_hsa049100.59047047
108Peroxisome_Homo sapiens_hsa041460.56750979
109VEGF signaling pathway_Homo sapiens_hsa043700.55940054
110HIF-1 signaling pathway_Homo sapiens_hsa040660.55529399
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.54975449
112Pyruvate metabolism_Homo sapiens_hsa006200.54553290
113Endometrial cancer_Homo sapiens_hsa052130.54533702
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54365784
115Fatty acid elongation_Homo sapiens_hsa000620.54305964
116Endocytosis_Homo sapiens_hsa041440.54118210
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.53687024
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52682195
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52123883
120Tight junction_Homo sapiens_hsa045300.51621180
121Pancreatic secretion_Homo sapiens_hsa049720.50405612
122Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50238666
123beta-Alanine metabolism_Homo sapiens_hsa004100.50159563
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48715351
125MicroRNAs in cancer_Homo sapiens_hsa052060.47965703
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47955889
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47381974
128mTOR signaling pathway_Homo sapiens_hsa041500.46412283
129Ras signaling pathway_Homo sapiens_hsa040140.46044502
130MAPK signaling pathway_Homo sapiens_hsa040100.45386698
131Glucagon signaling pathway_Homo sapiens_hsa049220.45215411
132Choline metabolism in cancer_Homo sapiens_hsa052310.44439843
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42124359
134Huntingtons disease_Homo sapiens_hsa050160.41165409
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40631037
136Tyrosine metabolism_Homo sapiens_hsa003500.40380734
137Butanoate metabolism_Homo sapiens_hsa006500.40093539
138Ether lipid metabolism_Homo sapiens_hsa005650.37566805
139Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37450269
140Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37318783

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