KLHDC8B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Mutations in this gene have been associated with Hodgkin lymphoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron projection extension involved in neuron projection guidance (GO:1902284)5.29883744
2axon extension involved in axon guidance (GO:0048846)5.29883744
3response to pheromone (GO:0019236)4.67752212
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.53556111
5pyrimidine nucleobase catabolic process (GO:0006208)4.20004662
6negative regulation of cytosolic calcium ion concentration (GO:0051481)4.19013280
7negative regulation of axon guidance (GO:1902668)4.11867054
8potassium ion export (GO:0071435)3.87764406
9substrate-independent telencephalic tangential migration (GO:0021826)3.87724757
10substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.87724757
11spinal cord association neuron differentiation (GO:0021527)3.77141573
12cell communication by electrical coupling (GO:0010644)3.74961028
13positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.65675560
14cell proliferation in forebrain (GO:0021846)3.57239530
15neuron fate determination (GO:0048664)3.55618516
16regulation of short-term neuronal synaptic plasticity (GO:0048172)3.53709426
17neuron recognition (GO:0008038)3.51608652
18protein neddylation (GO:0045116)3.50104850
19cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.49613080
20sequestering of actin monomers (GO:0042989)3.43518953
21positive regulation of potassium ion transmembrane transport (GO:1901381)3.42856067
22glucocorticoid biosynthetic process (GO:0006704)3.39113910
23negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.34082966
24cardiac myofibril assembly (GO:0055003)3.33351051
25membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.31174832
26camera-type eye morphogenesis (GO:0048593)3.27342533
27behavioral response to nicotine (GO:0035095)3.27224318
28dopaminergic neuron differentiation (GO:0071542)3.26556193
29axon extension (GO:0048675)3.23357549
30protein localization to synapse (GO:0035418)3.19414251
31regulation of membrane repolarization (GO:0060306)3.19063999
32growth hormone secretion (GO:0030252)3.18753296
33regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.18265889
34membrane repolarization during action potential (GO:0086011)3.17058541
35nucleobase catabolic process (GO:0046113)3.11852673
36regulation of axon guidance (GO:1902667)3.07521858
37membrane repolarization (GO:0086009)3.06445367
38short-term memory (GO:0007614)3.06201033
39retinal ganglion cell axon guidance (GO:0031290)3.05585261
40intraciliary transport (GO:0042073)3.04970142
41retinal rod cell development (GO:0046548)3.03882868
42synaptic vesicle maturation (GO:0016188)3.02303472
43dendritic spine morphogenesis (GO:0060997)2.99979152
44ganglion development (GO:0061548)2.98030646
45calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.97834206
46negative regulation of axon extension involved in axon guidance (GO:0048843)2.97187094
47synaptic transmission, cholinergic (GO:0007271)2.95024684
48epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.94115205
49epithelial cilium movement (GO:0003351)2.93249702
50negative regulation of appetite (GO:0032099)2.93117993
51negative regulation of response to food (GO:0032096)2.93117993
52synaptic vesicle exocytosis (GO:0016079)2.91184741
53positive regulation of synaptic transmission, GABAergic (GO:0032230)2.89320359
54outflow tract septum morphogenesis (GO:0003148)2.88248238
55neuronal stem cell maintenance (GO:0097150)2.87665993
56establishment of mitochondrion localization (GO:0051654)2.86670473
57neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.86405715
58regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.84340248
59presynaptic membrane organization (GO:0097090)2.83029623
60left/right pattern formation (GO:0060972)2.80698975
61innervation (GO:0060384)2.79639058
62positive regulation of mitochondrial fission (GO:0090141)2.78951613
63positive regulation of amino acid transport (GO:0051957)2.78352227
64viral protein processing (GO:0019082)2.77996724
65regulation of cilium movement (GO:0003352)2.77195938
66cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.76880839
67positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.76655368
68detection of light stimulus involved in sensory perception (GO:0050962)2.75604579
69detection of light stimulus involved in visual perception (GO:0050908)2.75604579
70lens fiber cell development (GO:0070307)2.74316690
71photoreceptor cell maintenance (GO:0045494)2.74297915
72regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.73513100
73regulation of cardioblast proliferation (GO:0003264)2.72500389
74regulation of secondary heart field cardioblast proliferation (GO:0003266)2.72500389
75postsynaptic membrane organization (GO:0001941)2.72307578
76neuronal ion channel clustering (GO:0045161)2.71431931
77cardiac muscle contraction (GO:0060048)2.71427442
78negative regulation of striated muscle cell apoptotic process (GO:0010664)2.69949451
79cell-cell junction maintenance (GO:0045217)2.69203193
80negative chemotaxis (GO:0050919)2.69030993
81potassium ion homeostasis (GO:0055075)2.68426172
82protein-chromophore linkage (GO:0018298)2.67056474
83muscle filament sliding (GO:0030049)2.66654088
84actin-myosin filament sliding (GO:0033275)2.66654088
85regulation of heart rate by cardiac conduction (GO:0086091)2.63997475
86G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.63421557
87regulation of synaptic vesicle exocytosis (GO:2000300)2.62627621
88heart process (GO:0003015)2.61440420
89heart contraction (GO:0060047)2.61440420
90tongue development (GO:0043586)2.60407934
91myofibril assembly (GO:0030239)2.59523883
92positive regulation of insulin secretion (GO:0032024)2.58067924
93neuron projection extension (GO:1990138)2.56972423
94atrial septum morphogenesis (GO:0060413)2.56497714
95transmission of nerve impulse (GO:0019226)2.55976636
96layer formation in cerebral cortex (GO:0021819)2.55875018
97catecholamine transport (GO:0051937)2.55682169
98nonmotile primary cilium assembly (GO:0035058)2.55572732
99regulation of vesicle fusion (GO:0031338)2.55557066
100neurotransmitter secretion (GO:0007269)2.55309426
101toxin metabolic process (GO:0009404)2.54616986
102regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.54495964
103neurotransmitter-gated ion channel clustering (GO:0072578)2.54259706
104positive regulation of gastrulation (GO:2000543)2.53927518
105photoreceptor cell development (GO:0042461)2.53549167
106response to prostaglandin E (GO:0034695)2.53309915
107ventricular cardiac muscle cell action potential (GO:0086005)2.52996313
108nitric oxide mediated signal transduction (GO:0007263)2.52756108
109mitochondrion transport along microtubule (GO:0047497)2.50681031
110establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.50681031
111striatum development (GO:0021756)2.50521650
112endocardial cushion morphogenesis (GO:0003203)2.50096183
113cell communication involved in cardiac conduction (GO:0086065)2.49453635
114regulation of glutamate receptor signaling pathway (GO:1900449)2.49362602
115cranial nerve morphogenesis (GO:0021602)2.46742312
116nephron tubule morphogenesis (GO:0072078)2.45676369
117nephron epithelium morphogenesis (GO:0072088)2.45676369
118detection of calcium ion (GO:0005513)2.44536011
119respiratory system process (GO:0003016)2.44481247
120axonal fasciculation (GO:0007413)2.44315448
121adult heart development (GO:0007512)2.44257613
122hippocampus development (GO:0021766)2.43464031
123synaptic vesicle docking involved in exocytosis (GO:0016081)2.43328993
124platelet dense granule organization (GO:0060155)2.42490122
125estrogen biosynthetic process (GO:0006703)2.42358947
126membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.41451006
127protoporphyrinogen IX metabolic process (GO:0046501)2.41024274
128eye photoreceptor cell development (GO:0042462)2.40848622
129cardiac muscle cell proliferation (GO:0060038)2.40704914
130somite development (GO:0061053)2.39996603
131viral transcription (GO:0019083)2.39467028
132regulation of synapse structural plasticity (GO:0051823)2.39372885
133cardiac conduction (GO:0061337)2.39069038
134energy coupled proton transport, down electrochemical gradient (GO:0015985)2.38929196
135ATP synthesis coupled proton transport (GO:0015986)2.38929196
136regulation of sequestering of triglyceride (GO:0010889)2.38578355
137adult feeding behavior (GO:0008343)2.38456999
138positive regulation of vesicle fusion (GO:0031340)2.38422596
139positive regulation of potassium ion transport (GO:0043268)2.38046075
140regulation of synaptic vesicle transport (GO:1902803)2.38038077
141regulation of microtubule-based movement (GO:0060632)2.37641655
142auditory behavior (GO:0031223)2.37360769
143cilium movement (GO:0003341)2.36455093
144neuron cell-cell adhesion (GO:0007158)2.36197465
145protein polyglutamylation (GO:0018095)2.36038082
146cell migration in hindbrain (GO:0021535)2.35962480
147gamma-aminobutyric acid transport (GO:0015812)2.35722231
148regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.35268113
149spinal cord development (GO:0021510)2.35081300
150presynaptic membrane assembly (GO:0097105)2.32844905
151actin-mediated cell contraction (GO:0070252)2.32825834
152atrial cardiac muscle cell action potential (GO:0086014)2.32661478
153mesenchyme morphogenesis (GO:0072132)2.32065810
154regulation of glycogen (starch) synthase activity (GO:2000465)2.31627933
155response to dietary excess (GO:0002021)2.31604562
156calcium-mediated signaling using intracellular calcium source (GO:0035584)2.31070868
157cholesterol biosynthetic process (GO:0006695)2.30738498
158renal tubule morphogenesis (GO:0061333)2.30615774
159olfactory bulb development (GO:0021772)2.30269039
160regulation of cAMP-dependent protein kinase activity (GO:2000479)2.30225899
161protoporphyrinogen IX biosynthetic process (GO:0006782)2.30060083
162establishment of tissue polarity (GO:0007164)2.29966479
163establishment of planar polarity (GO:0001736)2.29966479
164membrane depolarization during action potential (GO:0086010)2.29943680
165sodium ion export (GO:0071436)2.29222776
166mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.28835736
167regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.28731635
168cell differentiation in spinal cord (GO:0021515)2.28399536
169phosphatidylglycerol biosynthetic process (GO:0006655)2.28382838
170thalamus development (GO:0021794)2.27549289
171telencephalon development (GO:0021537)2.25607439
172axonemal dynein complex assembly (GO:0070286)2.25123334
173arginine catabolic process (GO:0006527)2.25028021
174regulation of axon extension involved in axon guidance (GO:0048841)2.24801189
175cell junction maintenance (GO:0034331)2.24710867
176adult walking behavior (GO:0007628)2.22604292
177sarcomere organization (GO:0045214)2.21133442
178forebrain neuron differentiation (GO:0021879)2.20404856
179protein localization to cilium (GO:0061512)2.18814024
180ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.18376274
181dendrite development (GO:0016358)2.16828794
182translational termination (GO:0006415)2.16818678
183dorsal/ventral neural tube patterning (GO:0021904)2.16090375
184sterol biosynthetic process (GO:0016126)2.15897027
185motile cilium assembly (GO:0044458)2.15501974

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.03660473
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.87290257
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.15031507
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11108702
5JARID2_20075857_ChIP-Seq_MESCs_Mouse3.10007380
6SUZ12_16625203_ChIP-ChIP_MESCs_Mouse3.06009709
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01438119
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95205133
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.92444578
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.91147542
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.86807702
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.83538211
13EZH2_27294783_Chip-Seq_ESCs_Mouse2.81496077
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.81334413
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.81334413
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59824720
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.48609768
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47551393
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.46251039
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45211558
21PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.39997451
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31784720
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.26165177
24BMI1_23680149_ChIP-Seq_NPCS_Mouse2.18884718
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18090237
26REST_21632747_ChIP-Seq_MESCs_Mouse2.14298128
27GBX2_23144817_ChIP-Seq_PC3_Human2.06771528
28OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.90148498
29DROSHA_22980978_ChIP-Seq_HELA_Human1.89237128
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.86165836
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.83785618
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.80120360
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58337558
34RING1B_27294783_Chip-Seq_ESCs_Mouse1.56485666
35EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.53287187
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51668685
37TP53_20018659_ChIP-ChIP_R1E_Mouse1.50828259
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.44729664
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40090274
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.40040222
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.37275743
42GATA1_26923725_Chip-Seq_HPCs_Mouse1.36729601
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36355038
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30860675
45RNF2_27304074_Chip-Seq_NSC_Mouse1.29986453
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28920352
47CTCF_27219007_Chip-Seq_Bcells_Human1.27468217
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27213955
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.26367018
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25501889
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23276681
52RING1B_27294783_Chip-Seq_NPCs_Mouse1.20927915
53* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20626638
54KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.20357446
55SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.18925894
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18542457
57RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17695289
58CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17556279
59WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13446956
60IGF1R_20145208_ChIP-Seq_DFB_Human1.12359102
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12326015
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11465815
63ISL1_27105846_Chip-Seq_CPCs_Mouse1.11212444
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.10938795
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10833411
66SMAD4_21799915_ChIP-Seq_A2780_Human1.10405611
67PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09284448
68* AR_19668381_ChIP-Seq_PC3_Human1.08388255
69* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.05710549
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05440476
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04202309
72STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03772461
73* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03701327
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02749919
75SMAD4_21741376_ChIP-Seq_HESCs_Human1.02120454
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00830518
77P300_19829295_ChIP-Seq_ESCs_Human0.99964829
78SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99230309
79SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98379798
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97203105
81SOX2_21211035_ChIP-Seq_LN229_Gbm0.96142025
82ZNF274_21170338_ChIP-Seq_K562_Hela0.95604380
83WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94921391
84SOX2_16153702_ChIP-ChIP_HESCs_Human0.94903489
85KDM2B_26808549_Chip-Seq_K562_Human0.94805922
86CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94558023
87IRF1_19129219_ChIP-ChIP_H3396_Human0.94314081
88PIAS1_25552417_ChIP-Seq_VCAP_Human0.94209976
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94040382
90RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93510195
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92413239
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91583645
93* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91401433
94SMAD3_21741376_ChIP-Seq_EPCs_Human0.91363782
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88427525
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87939141
97CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87084132
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86149786
99AR_25329375_ChIP-Seq_VCAP_Human0.86130398
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85856460
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85527280
102SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.85524156
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84999907
104DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84141388
105CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82802601
106EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81661631
107CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.81645127
108ZFP57_27257070_Chip-Seq_ESCs_Mouse0.81585861
109TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.79858560
110ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79425669
111ELK4_26923725_Chip-Seq_MESODERM_Mouse0.78697043
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.78684396
113YAP1_20516196_ChIP-Seq_MESCs_Mouse0.78572119
114KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.77929969
115CTCF_18555785_ChIP-Seq_MESCs_Mouse0.76427407
116SA1_22415368_ChIP-Seq_MEFs_Mouse0.76353542
117GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76097401
118RAD21_21589869_ChIP-Seq_MESCs_Mouse0.76086000
119LXR_22292898_ChIP-Seq_THP-1_Human0.76042041
120POU5F1_16153702_ChIP-ChIP_HESCs_Human0.75996259
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.75023018
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75023018
123SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.74964829
124MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.74632069
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74329111
126NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.73951774
127SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.73870925
128SOX3_22085726_ChIP-Seq_NPCs_Mouse0.73655217
129YY1_22570637_ChIP-Seq_MALME-3M_Human0.73481509
130E2F1_17053090_ChIP-ChIP_MCF-7_Human0.73462344
131ETV2_25802403_ChIP-Seq_MESCs_Mouse0.73262375
132BCAT_22108803_ChIP-Seq_LS180_Human0.72990145
133SMAD3_21741376_ChIP-Seq_ESCs_Human0.72631698
134AR_21572438_ChIP-Seq_LNCaP_Human0.71959945
135P53_22127205_ChIP-Seq_FIBROBLAST_Human0.71090411
136NANOG_21062744_ChIP-ChIP_HESCs_Human0.70202225

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.62456483
2MP0002638_abnormal_pupillary_reflex3.57461686
3MP0005645_abnormal_hypothalamus_physiol3.23832218
4MP0006072_abnormal_retinal_apoptosis3.02711110
5MP0010386_abnormal_urinary_bladder2.81813244
6MP0006292_abnormal_olfactory_placode2.78633405
7MP0005551_abnormal_eye_electrophysiolog2.72108777
8MP0006276_abnormal_autonomic_nervous2.46529693
9MP0003136_yellow_coat_color2.45703299
10MP0002837_dystrophic_cardiac_calcinosis2.41231790
11MP0000013_abnormal_adipose_tissue2.32710095
12MP0001502_abnormal_circadian_rhythm2.28085810
13MP0004084_abnormal_cardiac_muscle2.27439019
14MP0005253_abnormal_eye_physiology2.23214954
15MP0009379_abnormal_foot_pigmentation2.17092579
16MP0004859_abnormal_synaptic_plasticity2.12183926
17MP0001984_abnormal_olfaction1.90034951
18MP0002909_abnormal_adrenal_gland1.87492708
19MP0003121_genomic_imprinting1.86304340
20MP0002234_abnormal_pharynx_morphology1.83152172
21MP0004133_heterotaxia1.83115307
22MP0004215_abnormal_myocardial_fiber1.83066572
23MP0005423_abnormal_somatic_nervous1.79030795
24MP0004036_abnormal_muscle_relaxation1.73735909
25MP0003635_abnormal_synaptic_transmissio1.73385657
26MP0002184_abnormal_innervation1.70924293
27MP0001968_abnormal_touch/_nociception1.68810273
28MP0000751_myopathy1.68281402
29MP0005248_abnormal_Harderian_gland1.66206365
30MP0004147_increased_porphyrin_level1.62517432
31MP0004270_analgesia1.57995478
32MP0002090_abnormal_vision1.55631986
33MP0004130_abnormal_muscle_cell1.55072443
34MP0001293_anophthalmia1.51277580
35MP0002127_abnormal_cardiovascular_syste1.51227902
36MP0002734_abnormal_mechanical_nocicepti1.51046918
37MP0000778_abnormal_nervous_system1.47150060
38MP0000749_muscle_degeneration1.43998753
39MP0005646_abnormal_pituitary_gland1.42422033
40MP0000631_abnormal_neuroendocrine_gland1.40487153
41MP0002063_abnormal_learning/memory/cond1.39873800
42MP0000049_abnormal_middle_ear1.39331042
43MP0002938_white_spotting1.39307377
44MP0003137_abnormal_impulse_conducting1.37644768
45MP0005379_endocrine/exocrine_gland_phen1.36951838
46MP0001486_abnormal_startle_reflex1.36501648
47MP0005377_hearing/vestibular/ear_phenot1.35459546
48MP0003878_abnormal_ear_physiology1.35459546
49MP0002572_abnormal_emotion/affect_behav1.35272689
50MP0002102_abnormal_ear_morphology1.34574691
51MP0009745_abnormal_behavioral_response1.34509391
52MP0004858_abnormal_nervous_system1.33780007
53MP0003123_paternal_imprinting1.32764165
54MP0002735_abnormal_chemical_nociception1.31928927
55MP0003183_abnormal_peptide_metabolism1.31316433
56MP0002736_abnormal_nociception_after1.29641429
57MP0003787_abnormal_imprinting1.29605938
58MP0003283_abnormal_digestive_organ1.28991077
59MP0008775_abnormal_heart_ventricle1.28918217
60MP0002557_abnormal_social/conspecific_i1.28745357
61MP0005670_abnormal_white_adipose1.28159917
62MP0000026_abnormal_inner_ear1.27592100
63MP0002733_abnormal_thermal_nociception1.27235945
64MP0002751_abnormal_autonomic_nervous1.26283845
65MP0005083_abnormal_biliary_tract1.25732350
66MP0002064_seizures1.24957150
67MP0004085_abnormal_heartbeat1.23427246
68MP0002972_abnormal_cardiac_muscle1.23259834
69MP0005171_absent_coat_pigmentation1.22458462
70MP0004145_abnormal_muscle_electrophysio1.22089126
71MP0003011_delayed_dark_adaptation1.17523835
72MP0000750_abnormal_muscle_regeneration1.17318583
73MP0005195_abnormal_posterior_eye1.17293214
74MP0004142_abnormal_muscle_tone1.16061832
75MP0002233_abnormal_nose_morphology1.15914223
76MP0000003_abnormal_adipose_tissue1.14897678
77MP0008961_abnormal_basal_metabolism1.14083523
78MP0008789_abnormal_olfactory_epithelium1.12872552
79MP0002272_abnormal_nervous_system1.12315814
80MP0003880_abnormal_central_pattern1.12050775
81MP0001299_abnormal_eye_distance/1.12031468
82MP0009046_muscle_twitch1.09620154
83MP0005620_abnormal_muscle_contractility1.06202882
84MP0002882_abnormal_neuron_morphology1.05748944
85MP0001529_abnormal_vocalization1.04653942
86MP0002067_abnormal_sensory_capabilities1.03941874
87MP0005499_abnormal_olfactory_system1.03366143
88MP0005394_taste/olfaction_phenotype1.03366143
89MP0003938_abnormal_ear_development1.03311303
90MP0001970_abnormal_pain_threshold1.02934541
91MP0010030_abnormal_orbit_morphology1.02301558
92MP0001485_abnormal_pinna_reflex1.01679664
93MP0002653_abnormal_ependyma_morphology1.00293475
94MP0001986_abnormal_taste_sensitivity0.99824013
95MP0001440_abnormal_grooming_behavior0.99402027
96MP0005391_vision/eye_phenotype0.99194220
97MP0009053_abnormal_anal_canal0.99105047
98MP0000566_synostosis0.98240921
99MP0002752_abnormal_somatic_nervous0.97539278
100MP0002822_catalepsy0.94975057
101MP0003329_amyloid_beta_deposits0.94709635
102MP0003879_abnormal_hair_cell0.93359256
103MP0000955_abnormal_spinal_cord0.92755094
104MP0003119_abnormal_digestive_system0.91976301
105MP0002152_abnormal_brain_morphology0.91327213
106MP0009780_abnormal_chondrocyte_physiolo0.91079843
107MP0001501_abnormal_sleep_pattern0.90050174
108MP0000372_irregular_coat_pigmentation0.88630848
109MP0003646_muscle_fatigue0.88605999
110MP0000534_abnormal_ureter_morphology0.87405105
111MP0002163_abnormal_gland_morphology0.85921566
112MP0000230_abnormal_systemic_arterial0.85330255
113MP0003861_abnormal_nervous_system0.84919501
114MP0004811_abnormal_neuron_physiology0.84101625
115MP0003942_abnormal_urinary_system0.83954970
116MP0004924_abnormal_behavior0.83132677
117MP0005386_behavior/neurological_phenoty0.83132677
118MP0003186_abnormal_redox_activity0.82886276
119MP0005330_cardiomyopathy0.82641526
120MP0002249_abnormal_larynx_morphology0.80847416
121MP0002069_abnormal_eating/drinking_beha0.79454821
122MP0001324_abnormal_eye_pigmentation0.79257077
123MP0001286_abnormal_eye_development0.79087225
124MP0001270_distended_abdomen0.78599373
125MP0003890_abnormal_embryonic-extraembry0.78207527
126MP0002092_abnormal_eye_morphology0.77745901
127MP0003385_abnormal_body_wall0.77210546
128MP0003195_calcinosis0.76897397
129MP0006138_congestive_heart_failure0.76326529
130MP0003959_abnormal_lean_body0.76127967
131MP0002697_abnormal_eye_size0.75610159
132MP0004272_abnormal_basement_membrane0.73941954
133MP0001544_abnormal_cardiovascular_syste0.73345772
134MP0005385_cardiovascular_system_phenoty0.73345772
135MP0002229_neurodegeneration0.72843553
136MP0005167_abnormal_blood-brain_barrier0.71359469
137MP0005666_abnormal_adipose_tissue0.70881315
138MP0004885_abnormal_endolymph0.70125285
139MP0000639_abnormal_adrenal_gland0.68686257
140MP0001963_abnormal_hearing_physiology0.68242599
141MP0002106_abnormal_muscle_physiology0.67650393
142MP0008995_early_reproductive_senescence0.67435238
143MP0003755_abnormal_palate_morphology0.66807845

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)4.24668925
2Congenital stationary night blindness (HP:0007642)4.23929890
3Prolonged QT interval (HP:0001657)4.01927052
4Abnormal rod and cone electroretinograms (HP:0008323)3.83370326
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.72748294
6Scotoma (HP:0000575)3.45069809
7Abnormality of calcium-phosphate metabolism (HP:0100530)3.17809476
8Hypoventilation (HP:0002791)3.17457256
9Limb dystonia (HP:0002451)3.17295853
10Abnormality of the heme biosynthetic pathway (HP:0010472)3.12266155
11Rib fusion (HP:0000902)3.05700867
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.02515401
13Abnormal EKG (HP:0003115)3.00251706
14Bony spicule pigmentary retinopathy (HP:0007737)2.97395433
15True hermaphroditism (HP:0010459)2.95854209
16Cortical dysplasia (HP:0002539)2.94812800
17Failure to thrive in infancy (HP:0001531)2.91962309
18Hypothermia (HP:0002045)2.91811977
19Pheochromocytoma (HP:0002666)2.88224277
20Abnormality of macular pigmentation (HP:0008002)2.87885805
21Severe visual impairment (HP:0001141)2.87747593
22Abnormal hair whorl (HP:0010721)2.85391474
23Agitation (HP:0000713)2.83143340
24Septo-optic dysplasia (HP:0100842)2.79295586
25Epileptic encephalopathy (HP:0200134)2.70835419
26Pancreatic fibrosis (HP:0100732)2.70505359
27Left ventricular hypertrophy (HP:0001712)2.69265984
28Ventricular fibrillation (HP:0001663)2.66934416
29Occipital encephalocele (HP:0002085)2.65406219
30Syncope (HP:0001279)2.63580158
31High anterior hairline (HP:0009890)2.63085184
32Growth hormone excess (HP:0000845)2.60721963
33Sudden death (HP:0001699)2.59707776
34Atrial fibrillation (HP:0005110)2.58106142
35Hypoglycemic seizures (HP:0002173)2.57904085
36Ketoacidosis (HP:0001993)2.55213839
37Polyphagia (HP:0002591)2.53780693
38Increased corneal curvature (HP:0100692)2.51394638
39Keratoconus (HP:0000563)2.51394638
40Primary atrial arrhythmia (HP:0001692)2.51173956
41Chorioretinal atrophy (HP:0000533)2.48655872
42Neoplasm of the heart (HP:0100544)2.46812738
43Retinal atrophy (HP:0001105)2.46032252
44Supraventricular tachycardia (HP:0004755)2.44954580
45Supraventricular arrhythmia (HP:0005115)2.44564775
46Gait imbalance (HP:0002141)2.41356541
47Hemiparesis (HP:0001269)2.41210624
48Pendular nystagmus (HP:0012043)2.39602165
49Anxiety (HP:0000739)2.39198681
50Symptomatic seizures (HP:0011145)2.38769528
51Exercise-induced myalgia (HP:0003738)2.37171461
52Febrile seizures (HP:0002373)2.36876382
53Aplasia/Hypoplasia of the lens (HP:0008063)2.36758603
54Abnormality of the aortic arch (HP:0012303)2.36561321
55Neuroendocrine neoplasm (HP:0100634)2.35713918
56Muscle fiber splitting (HP:0003555)2.33168064
57Anomalous pulmonary venous return (HP:0010772)2.32167458
58Molar tooth sign on MRI (HP:0002419)2.31576812
59Abnormality of midbrain morphology (HP:0002418)2.31576812
60Nephronophthisis (HP:0000090)2.28943880
61Reticulocytosis (HP:0001923)2.28536013
62Decreased circulating renin level (HP:0003351)2.28476623
63Decreased central vision (HP:0007663)2.27897752
64Abnormality of cells of the erythroid lineage (HP:0012130)2.27186216
65Myokymia (HP:0002411)2.26678303
66Hyperinsulinemic hypoglycemia (HP:0000825)2.25076320
67Narrow nasal bridge (HP:0000446)2.23889880
68Anophthalmia (HP:0000528)2.23725967
69Rimmed vacuoles (HP:0003805)2.22114193
70Anencephaly (HP:0002323)2.19185738
71Ankle clonus (HP:0011448)2.18452663
72Congenital primary aphakia (HP:0007707)2.18403938
73Ventricular arrhythmia (HP:0004308)2.16734538
74Hyperglycinemia (HP:0002154)2.16662446
75Myotonia (HP:0002486)2.16653504
76Sclerocornea (HP:0000647)2.16335661
77Hypoplastic pelvis (HP:0008839)2.15712765
78Abolished electroretinogram (ERG) (HP:0000550)2.15559762
79Abnormal respiratory epithelium morphology (HP:0012253)2.15207107
80Abnormal respiratory motile cilium morphology (HP:0005938)2.15207107
81Abnormal ciliary motility (HP:0012262)2.14214074
82Bifid tongue (HP:0010297)2.14049616
83Palpitations (HP:0001962)2.12405541
84Abnormal number of erythroid precursors (HP:0012131)2.12245971
85Abnormality of abdominal situs (HP:0011620)2.10962712
86Abdominal situs inversus (HP:0003363)2.10962712
87Abnormality of the fovea (HP:0000493)2.10336094
88Depression (HP:0000716)2.09098875
89Sleep apnea (HP:0010535)2.08275432
90Maternal diabetes (HP:0009800)2.06196262
91Calf muscle hypertrophy (HP:0008981)2.05187860
92Late onset (HP:0003584)2.04942151
93Poor suck (HP:0002033)2.04255291
94Abnormal hemoglobin (HP:0011902)2.03897347
95Intestinal atresia (HP:0011100)2.03142911
96Pancreatic cysts (HP:0001737)2.03030373
97Aplasia/Hypoplasia of the fovea (HP:0008060)2.02148057
98Hypoplasia of the fovea (HP:0007750)2.02148057
99Type II diabetes mellitus (HP:0005978)2.01024894
100Difficulty running (HP:0009046)2.00862482
101Abnormality of reticulocytes (HP:0004312)2.00393153
102Renal duplication (HP:0000075)2.00169820
103Abnormality of the calf musculature (HP:0001430)1.99648514
104Torticollis (HP:0000473)1.98574209
105Hip dysplasia (HP:0001385)1.97918164
106Poor coordination (HP:0002370)1.97422952
107Menstrual irregularities (HP:0000858)1.96268507
108Hypoplasia of the brainstem (HP:0002365)1.95979827
109Aplasia/Hypoplasia of the brainstem (HP:0007362)1.95979827
110Hepatoblastoma (HP:0002884)1.95665497
111Hypercortisolism (HP:0001578)1.95299395
112Specific learning disability (HP:0001328)1.94358216
113Exercise-induced muscle cramps (HP:0003710)1.93102203
114Abnormal respiratory motile cilium physiology (HP:0012261)1.92250386
115Pigmentary retinal degeneration (HP:0001146)1.92034828
116Hypoglycemic coma (HP:0001325)1.91355598
117Abnormality of the pulmonary veins (HP:0011718)1.91305381
118Abnormal gallbladder physiology (HP:0012438)1.88910559
119Cholecystitis (HP:0001082)1.88910559
120Hip contracture (HP:0003273)1.88300076
121Aplasia/Hypoplasia of the tongue (HP:0010295)1.88043119
122Abnormal pupillary function (HP:0007686)1.87083187
123Decreased testicular size (HP:0008734)1.86576708
124Labial hypoplasia (HP:0000066)1.86431375
125Morphological abnormality of the middle ear (HP:0008609)1.85002068
126Renal dysplasia (HP:0000110)1.84847074
127Postaxial hand polydactyly (HP:0001162)1.84047334
128Renal Fanconi syndrome (HP:0001994)1.83988553
129Myoglobinuria (HP:0002913)1.83650522
130EEG with generalized epileptiform discharges (HP:0011198)1.82898785
131Tubulointerstitial fibrosis (HP:0005576)1.82723381
132Dyschromatopsia (HP:0007641)1.82119203
133Cholelithiasis (HP:0001081)1.81119688
134Growth hormone deficiency (HP:0000824)1.80814843
135Nephrogenic diabetes insipidus (HP:0009806)1.80094626
136Hemivertebrae (HP:0002937)1.79457089
137Cystic liver disease (HP:0006706)1.78948356
138Absent septum pellucidum (HP:0001331)1.78797929
139Amblyopia (HP:0000646)1.78741265
140Genital tract atresia (HP:0001827)1.78547435
141Male pseudohermaphroditism (HP:0000037)1.78206837
142Abnormal eating behavior (HP:0100738)1.76687680
143Broad distal phalanx of finger (HP:0009836)1.76297345
144Vaginal atresia (HP:0000148)1.76295988
145Congenital malformation of the right heart (HP:0011723)1.76171923
146Double outlet right ventricle (HP:0001719)1.76171923
147Pachygyria (HP:0001302)1.76163330
148Visual hallucinations (HP:0002367)1.76082219
149Medial flaring of the eyebrow (HP:0010747)1.76037340
150Short 4th metacarpal (HP:0010044)1.75966135
151Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.75966135
152Insomnia (HP:0100785)1.75197576
153Abnormality of the left ventricular outflow tract (HP:0011103)1.73826256
154Subaortic stenosis (HP:0001682)1.73826256
155Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73734319
156Neoplasm of the adrenal gland (HP:0100631)1.73321477
157Mutism (HP:0002300)1.73299943
158Pancreatic islet-cell hyperplasia (HP:0004510)1.73170437
159Epileptiform EEG discharges (HP:0011182)1.72166286
160Osteomalacia (HP:0002749)1.72043833
161Ragged-red muscle fibers (HP:0003200)1.71408516
162Vitreoretinal degeneration (HP:0000655)1.70829009
163Large for gestational age (HP:0001520)1.70794706
164Retinitis pigmentosa (HP:0000510)1.70626636
165Focal dystonia (HP:0004373)1.70310919
166Nuclear cataract (HP:0100018)1.70259685
167Adrenal hypoplasia (HP:0000835)1.69802182
168Craniofacial dystonia (HP:0012179)1.69640728
169Sex reversal (HP:0012245)1.69090262
170Abnormal sex determination (HP:0012244)1.69090262
171Supernumerary spleens (HP:0009799)1.68179730
172Increased muscle lipid content (HP:0009058)1.67943401
173Abnormality of the renal medulla (HP:0100957)1.67592409
174Anosmia (HP:0000458)1.67444254
175Chronic hepatic failure (HP:0100626)1.65193843
176Congenital hepatic fibrosis (HP:0002612)1.63675145
177Partial duplication of thumb phalanx (HP:0009944)1.62446877
178Increased intramyocellular lipid droplets (HP:0012240)1.62306207
179Postaxial foot polydactyly (HP:0001830)1.61834237
180Oligomenorrhea (HP:0000876)1.61282519
181Meningocele (HP:0002435)1.61017133
182Optic nerve hypoplasia (HP:0000609)1.59884362
183Aplasia of the musculature (HP:0100854)1.59528177
184Disproportionate short-trunk short stature (HP:0003521)1.59256773

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.47759427
2MAPK153.66908747
3WNK33.40557912
4MARK12.74432385
5MYLK2.48757371
6SIK32.32494226
7EPHA32.01428640
8TNIK1.97338804
9NTRK21.96786845
10UHMK11.95085208
11OBSCN1.92875137
12EPHB21.86136271
13PHKG11.85958281
14PHKG21.85958281
15BMPR1B1.82879446
16NTRK31.76822457
17MAP3K111.74583122
18MINK11.72980183
19MAPK131.72889390
20MAP3K61.69825869
21MAP3K91.69819449
22MAP2K71.66044108
23PAK31.61307976
24PIK3CG1.57347057
25KSR11.56510680
26TRIM281.51856459
27MAP3K41.50925128
28MAP2K61.37415707
29CAMK11.35230468
30DDR21.29348712
31CDC42BPA1.28643792
32EPHB11.28503311
33PAK61.25652890
34LMTK21.24741169
35IRAK21.24059858
36RPS6KA21.23237234
37CSNK1G21.20939798
38PRKD31.19385802
39MAP4K21.15998883
40HIPK21.15148134
41CDK191.14812388
42TIE11.09447714
43TGFBR11.09425378
44DYRK21.06303945
45CAMK1G1.05538580
46GRK71.04641777
47LIMK11.02098795
48CSNK1G30.99741951
49MAP2K40.99050393
50ERBB30.98119647
51DAPK20.97725436
52NME10.97190522
53DYRK1B0.94255302
54SIK10.92872784
55ERBB20.89546747
56GRK50.89188769
57ADRBK10.88485064
58ARAF0.87708228
59TYRO30.86295991
60PIM20.82795715
61ERN10.82070926
62DYRK1A0.81915310
63CDK80.81314048
64NEK20.80965826
65CAMK40.80119200
66DYRK30.79800273
67SGK2230.79573391
68SGK4940.79573391
69ZAK0.79031170
70DAPK30.78746958
71STK110.77139615
72CSNK1A1L0.73973904
73PRKD20.73656464
74PKN10.73245992
75MAPK120.73016930
76BMX0.72918925
77ABL20.72517681
78MAP3K50.72027801
79PINK10.71878703
80BCKDK0.71338655
81PRKD10.69514797
82PRKAA10.66409671
83CASK0.65744933
84TGFBR20.65565474
85PTK2B0.65272700
86FGFR20.64204340
87SIK20.63723232
88SGK20.63654064
89WNK40.63580360
90CDK140.63372257
91CSNK1G10.63080888
92STK160.63064228
93PDGFRA0.62164846
94BCR0.61679017
95CDK50.61552842
96ADRBK20.61330570
97MARK20.60603940
98KSR20.60575332
99NEK60.59941933
100TTN0.59656370
101RPS6KA60.59192028
102MAPK70.58568388
103PRKACG0.58098005
104PRKCE0.56167601
105MAP3K120.55905088
106MUSK0.54468093
107MAP2K10.53606129
108LRRK20.53507239
109CDK180.52953378
110CDK11A0.52513373
111DMPK0.52174899
112PRKCZ0.51758147
113PRKCH0.51204135
114CDK150.51089630
115AKT20.49936572
116FER0.49886239
117RPS6KC10.49261242
118RPS6KL10.49261242
119CDK30.48983619
120RET0.48934936
121PRKCG0.48389732
122GRK10.46129938
123PRKAA20.45789622
124CAMKK10.45390986
125PAK20.45172509
126MAPK40.43900696
127TESK10.43518127
128CAMK2A0.43433368
129ROCK10.43272089
130STK240.43045416
131MAP3K70.42534397
132EPHA40.41333567
133NTRK10.40390867
134PRKACA0.40152819
135CAMK1D0.40093869
136PLK20.38938933
137PTK60.38484515
138CAMKK20.36476965

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042603.18989968
2Phototransduction_Homo sapiens_hsa047442.96515269
3Steroid biosynthesis_Homo sapiens_hsa001002.74203679
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.69719103
5Insulin secretion_Homo sapiens_hsa049112.63825835
6GABAergic synapse_Homo sapiens_hsa047272.55679440
7Synaptic vesicle cycle_Homo sapiens_hsa047212.53742285
8Circadian entrainment_Homo sapiens_hsa047132.33858789
9Nicotine addiction_Homo sapiens_hsa050332.27591347
10Parkinsons disease_Homo sapiens_hsa050122.26182215
11Oxidative phosphorylation_Homo sapiens_hsa001902.17098667
12Circadian rhythm_Homo sapiens_hsa047102.07156280
13Morphine addiction_Homo sapiens_hsa050321.96738003
14Dilated cardiomyopathy_Homo sapiens_hsa054141.95824155
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.95660965
16Fatty acid elongation_Homo sapiens_hsa000621.94863313
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.91920232
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.90733224
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.87729747
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.82870791
21Ribosome_Homo sapiens_hsa030101.82361095
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75784969
23Cocaine addiction_Homo sapiens_hsa050301.75254723
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.71556699
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.70295683
26Taste transduction_Homo sapiens_hsa047421.58063969
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57380967
28Olfactory transduction_Homo sapiens_hsa047401.56210738
29Alzheimers disease_Homo sapiens_hsa050101.55701793
30Dopaminergic synapse_Homo sapiens_hsa047281.54722249
31Cholinergic synapse_Homo sapiens_hsa047251.54395328
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.53369937
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51710244
34Renin secretion_Homo sapiens_hsa049241.49811611
35Huntingtons disease_Homo sapiens_hsa050161.47231250
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46835242
37Glutamatergic synapse_Homo sapiens_hsa047241.46797736
38Serotonergic synapse_Homo sapiens_hsa047261.37426485
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37401461
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37330068
41Amphetamine addiction_Homo sapiens_hsa050311.33681251
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.26828569
43Oxytocin signaling pathway_Homo sapiens_hsa049211.23230206
44PPAR signaling pathway_Homo sapiens_hsa033201.21662076
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21517447
46Salivary secretion_Homo sapiens_hsa049701.13194496
47Type II diabetes mellitus_Homo sapiens_hsa049301.12645857
48Melanogenesis_Homo sapiens_hsa049161.11781807
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10349740
50cAMP signaling pathway_Homo sapiens_hsa040241.09832050
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09324736
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.08285036
53Glucagon signaling pathway_Homo sapiens_hsa049221.06574349
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.06440926
55Vibrio cholerae infection_Homo sapiens_hsa051101.05209784
56Calcium signaling pathway_Homo sapiens_hsa040201.04715355
57Carbon metabolism_Homo sapiens_hsa012001.02829118
58Hedgehog signaling pathway_Homo sapiens_hsa043401.02547321
59Axon guidance_Homo sapiens_hsa043600.97008928
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.96641184
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93427228
62Peroxisome_Homo sapiens_hsa041460.93246434
63Sulfur relay system_Homo sapiens_hsa041220.93225200
64Gastric acid secretion_Homo sapiens_hsa049710.92100114
65ECM-receptor interaction_Homo sapiens_hsa045120.90137233
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87949151
67Basal cell carcinoma_Homo sapiens_hsa052170.87860044
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86061816
69Collecting duct acid secretion_Homo sapiens_hsa049660.86045572
70GnRH signaling pathway_Homo sapiens_hsa049120.85076159
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84897797
72Prion diseases_Homo sapiens_hsa050200.84201518
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82296366
74Gap junction_Homo sapiens_hsa045400.81066535
75Glycerolipid metabolism_Homo sapiens_hsa005610.80766327
76AMPK signaling pathway_Homo sapiens_hsa041520.80051112
77Arginine and proline metabolism_Homo sapiens_hsa003300.78653315
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78410792
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75698231
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73474595
81Insulin signaling pathway_Homo sapiens_hsa049100.71408094
82Biosynthesis of amino acids_Homo sapiens_hsa012300.69326680
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68636701
84Fat digestion and absorption_Homo sapiens_hsa049750.68511344
85Notch signaling pathway_Homo sapiens_hsa043300.67394793
86beta-Alanine metabolism_Homo sapiens_hsa004100.66132392
87Thyroid hormone synthesis_Homo sapiens_hsa049180.65628029
88Wnt signaling pathway_Homo sapiens_hsa043100.62213143
89Ovarian steroidogenesis_Homo sapiens_hsa049130.62173314
90Glutathione metabolism_Homo sapiens_hsa004800.61557578
91Long-term depression_Homo sapiens_hsa047300.58624783
92Protein export_Homo sapiens_hsa030600.57218230
93Regulation of autophagy_Homo sapiens_hsa041400.56964041
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56935044
95Estrogen signaling pathway_Homo sapiens_hsa049150.56614758
96Long-term potentiation_Homo sapiens_hsa047200.55917479
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55748805
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53892364
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53331369
100Tight junction_Homo sapiens_hsa045300.52098845
101Hippo signaling pathway_Homo sapiens_hsa043900.51499490
102Pyruvate metabolism_Homo sapiens_hsa006200.51431388
103Metabolic pathways_Homo sapiens_hsa011000.51427018
104Lysosome_Homo sapiens_hsa041420.51269279
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50648516
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50542583
107N-Glycan biosynthesis_Homo sapiens_hsa005100.50186292
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49242838
109Type I diabetes mellitus_Homo sapiens_hsa049400.48698730
110ABC transporters_Homo sapiens_hsa020100.48686299
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48443135
112Tryptophan metabolism_Homo sapiens_hsa003800.48236888
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47826976
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47157382
115Phagosome_Homo sapiens_hsa041450.46825154
116Fatty acid metabolism_Homo sapiens_hsa012120.45585451
117Alcoholism_Homo sapiens_hsa050340.44109801
118Rap1 signaling pathway_Homo sapiens_hsa040150.42655428
119Galactose metabolism_Homo sapiens_hsa000520.41322324
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39959004
121Tyrosine metabolism_Homo sapiens_hsa003500.38834543
122Fatty acid degradation_Homo sapiens_hsa000710.38678409
123Bile secretion_Homo sapiens_hsa049760.37962884
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37557616
125Endometrial cancer_Homo sapiens_hsa052130.36934474
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36828745
127Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35091023
128Pancreatic secretion_Homo sapiens_hsa049720.34410000
129Propanoate metabolism_Homo sapiens_hsa006400.33588647
130Lysine degradation_Homo sapiens_hsa003100.33440502
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.32834247
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.31842268
133Protein digestion and absorption_Homo sapiens_hsa049740.31705879
134Insulin resistance_Homo sapiens_hsa049310.31686434
135Butanoate metabolism_Homo sapiens_hsa006500.31283250
136Phenylalanine metabolism_Homo sapiens_hsa003600.31081640
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.30382984

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