KLHL11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.33273309
2monoubiquitinated protein deubiquitination (GO:0035520)5.20275167
3nuclear pore organization (GO:0006999)4.87848561
4pyrimidine dimer repair (GO:0006290)4.63349655
5regulation of RNA export from nucleus (GO:0046831)4.60152691
6pre-miRNA processing (GO:0031054)4.50520971
7piRNA metabolic process (GO:0034587)4.36673764
8COPI coating of Golgi vesicle (GO:0048205)4.29804810
9Golgi transport vesicle coating (GO:0048200)4.29804810
10regulation of nucleobase-containing compound transport (GO:0032239)4.02512427
11mitotic sister chromatid cohesion (GO:0007064)3.99763643
12positive regulation of mitochondrial fission (GO:0090141)3.95202144
13synaptonemal complex assembly (GO:0007130)3.83117431
14pore complex assembly (GO:0046931)3.82890357
15mitotic chromosome condensation (GO:0007076)3.80490592
16COPII vesicle coating (GO:0048208)3.68090334
17regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.60219292
18regulation of NFAT protein import into nucleus (GO:0051532)3.59677680
19spliceosomal tri-snRNP complex assembly (GO:0000244)3.59316444
20regulation of translational termination (GO:0006449)3.52233220
21male meiosis (GO:0007140)3.51958616
22regulation of short-term neuronal synaptic plasticity (GO:0048172)3.50640420
23peptidyl-lysine dimethylation (GO:0018027)3.44860350
24protein localization to kinetochore (GO:0034501)3.43807483
25DNA unwinding involved in DNA replication (GO:0006268)3.42805138
26histone H3-K9 demethylation (GO:0033169)3.42482469
27regulation of clathrin-mediated endocytosis (GO:2000369)3.41769921
28synaptonemal complex organization (GO:0070193)3.35954249
29gene silencing by RNA (GO:0031047)3.34718795
30cytoplasmic mRNA processing body assembly (GO:0033962)3.34198446
31negative regulation of histone methylation (GO:0031061)3.31296485
32histone H2A monoubiquitination (GO:0035518)3.30713877
33positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.25990204
34mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.25990204
35NLS-bearing protein import into nucleus (GO:0006607)3.25222562
36regulation of meiosis I (GO:0060631)3.24798624
37regulation of spindle organization (GO:0090224)3.23478972
38protein localization to chromosome, centromeric region (GO:0071459)3.21670534
39negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.20501563
40positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.19428360
41positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.19428360
42positive regulation of mitotic sister chromatid separation (GO:1901970)3.19428360
43mitotic metaphase plate congression (GO:0007080)3.14132233
44regulation of sister chromatid cohesion (GO:0007063)3.09692288
45non-recombinational repair (GO:0000726)3.08453453
46double-strand break repair via nonhomologous end joining (GO:0006303)3.08453453
47sister chromatid cohesion (GO:0007062)3.07477121
48regulation of mitotic spindle organization (GO:0060236)3.02918406
49retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.01453706
50histone lysine demethylation (GO:0070076)2.97844156
51regulation of histone H3-K9 methylation (GO:0051570)2.96656288
52regulation of centriole replication (GO:0046599)2.95490751
53establishment of nucleus localization (GO:0040023)2.93961894
54membrane disassembly (GO:0030397)2.93324896
55nuclear envelope disassembly (GO:0051081)2.93324896
56histone demethylation (GO:0016577)2.90177152
57microtubule nucleation (GO:0007020)2.90118515
58positive regulation of chromosome segregation (GO:0051984)2.89917975
59vesicle coating (GO:0006901)2.89680196
60ribonucleoprotein complex disassembly (GO:0032988)2.88758227
61mitotic nuclear envelope disassembly (GO:0007077)2.87845426
62vesicle transport along microtubule (GO:0047496)2.87341541
63protein K11-linked deubiquitination (GO:0035871)2.86259276
64DNA synthesis involved in DNA repair (GO:0000731)2.85367373
65meiotic nuclear division (GO:0007126)2.84947830
66microtubule depolymerization (GO:0007019)2.83802849
67protein demethylation (GO:0006482)2.82097825
68protein dealkylation (GO:0008214)2.82097825
69sister chromatid segregation (GO:0000819)2.79464068
70DNA methylation involved in gamete generation (GO:0043046)2.76438061
71stress granule assembly (GO:0034063)2.76429070
72gene silencing (GO:0016458)2.76320829
73regulation of helicase activity (GO:0051095)2.76227009
74histone H2B ubiquitination (GO:0033523)2.75798495
75DNA replication-dependent nucleosome organization (GO:0034723)2.75744369
76DNA replication-dependent nucleosome assembly (GO:0006335)2.75744369
77endoplasmic reticulum organization (GO:0007029)2.74053290
78androgen receptor signaling pathway (GO:0030521)2.74043187
79positive regulation of receptor biosynthetic process (GO:0010870)2.70910727
80negative regulation of oligodendrocyte differentiation (GO:0048715)2.70712411
81microtubule anchoring (GO:0034453)2.70679275
82attachment of spindle microtubules to kinetochore (GO:0008608)2.70172413
83mitochondrial fission (GO:0000266)2.69957759
84negative regulation of DNA repair (GO:0045738)2.69344384
85regulation of DNA damage checkpoint (GO:2000001)2.68465172
86organelle transport along microtubule (GO:0072384)2.68115584
87negative regulation of hormone metabolic process (GO:0032351)2.67844787
88negative regulation of hormone biosynthetic process (GO:0032353)2.67844787
89pyrimidine nucleobase catabolic process (GO:0006208)2.67764480
90histone H3-K9 methylation (GO:0051567)2.67712994
91negative regulation of circadian rhythm (GO:0042754)2.67496700
92nuclear envelope organization (GO:0006998)2.67493207
93negative regulation of DNA recombination (GO:0045910)2.67308087
94negative regulation of organelle assembly (GO:1902116)2.65422247
95olfactory bulb development (GO:0021772)2.64739804
96negative regulation of translation, ncRNA-mediated (GO:0040033)2.64472365
97regulation of translation, ncRNA-mediated (GO:0045974)2.64472365
98negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.64472365
99protein localization to microtubule (GO:0035372)2.64464750
100metaphase plate congression (GO:0051310)2.64208484
101protein localization to chromosome (GO:0034502)2.62959020
102fibroblast migration (GO:0010761)2.62776729
103locomotory exploration behavior (GO:0035641)2.62372947
104protein destabilization (GO:0031648)2.61829924
105positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.61577727
106establishment of protein localization to Golgi (GO:0072600)2.61002160
107mitotic spindle organization (GO:0007052)2.60565978
108regulation of chromosome segregation (GO:0051983)2.60422093
109protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.60124348
110synaptic vesicle maturation (GO:0016188)2.59575755
111morphogenesis of an epithelial sheet (GO:0002011)2.59190600
112rRNA catabolic process (GO:0016075)2.59145319
113peptidyl-threonine phosphorylation (GO:0018107)2.59042768
114regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.57962507
115negative regulation of neurotransmitter secretion (GO:0046929)2.57669414
116regulation of ARF protein signal transduction (GO:0032012)2.57298425
117chromosome organization involved in meiosis (GO:0070192)2.55013097
118spindle checkpoint (GO:0031577)2.54889356
119RNA localization (GO:0006403)2.54672916
120response to UV-C (GO:0010225)2.54409412
121ribosome assembly (GO:0042255)2.54046974
122protein targeting to Golgi (GO:0000042)2.53419048
123histone phosphorylation (GO:0016572)2.53406954
124regulation of centrosome cycle (GO:0046605)2.53205320
125histone H3-K36 demethylation (GO:0070544)2.53159574
126spindle assembly checkpoint (GO:0071173)2.52349476
127regulation of protein polyubiquitination (GO:1902914)2.52229038
128protein K48-linked deubiquitination (GO:0071108)2.51144062
129intra-Golgi vesicle-mediated transport (GO:0006891)2.50550615
130chromatin assembly or disassembly (GO:0006333)2.49232869
131DNA duplex unwinding (GO:0032508)2.48373810
132acrosome assembly (GO:0001675)2.48105723
133mitotic sister chromatid segregation (GO:0000070)2.47938399
134ectodermal placode formation (GO:0060788)2.47829777
135sodium ion export (GO:0071436)2.47552448
136resolution of meiotic recombination intermediates (GO:0000712)2.47014673
137layer formation in cerebral cortex (GO:0021819)2.46637404
138spindle assembly involved in mitosis (GO:0090307)2.46400820
139DNA geometric change (GO:0032392)2.45960241
140male meiosis I (GO:0007141)2.45952152
141regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.45897648
142regulation of mitotic metaphase/anaphase transition (GO:0030071)2.45897648
143establishment of chromosome localization (GO:0051303)2.45812429
144regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.45729690
145peptidyl-threonine modification (GO:0018210)2.44810420
146spermatid nucleus differentiation (GO:0007289)2.44171893
147calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.44145735
148mRNA transport (GO:0051028)2.43025212
149nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.42684834
150glucocorticoid receptor signaling pathway (GO:0042921)2.42497976
151nucleus organization (GO:0006997)2.41372627
152protein K6-linked ubiquitination (GO:0085020)2.40499552
153corticosteroid receptor signaling pathway (GO:0031958)2.40135067
154positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.39349764
155regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.39349764
156chromatin assembly (GO:0031497)2.39184824
157dosage compensation (GO:0007549)2.38531268
158peptidyl-threonine dephosphorylation (GO:0035970)2.38234146
159positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.37510120
160meiosis I (GO:0007127)2.37209551

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.94466833
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.87484092
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.58307315
4E2F7_22180533_ChIP-Seq_HELA_Human5.09247007
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.55731485
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.46765970
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.17395849
8PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.94462440
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.92459915
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.59404432
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43154666
12* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37274837
13PADI4_21655091_ChIP-ChIP_MCF-7_Human2.26132302
14TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.16656787
15DCP1A_22483619_ChIP-Seq_HELA_Human2.14144229
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.11820458
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.09155252
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05173774
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04822717
20VDR_23849224_ChIP-Seq_CD4+_Human2.00548866
21* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.00382005
22ELK1_19687146_ChIP-ChIP_HELA_Human1.99439301
23POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.97901281
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.97003647
25TAF15_26573619_Chip-Seq_HEK293_Human1.96492087
26SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.91081934
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.89114679
28* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84829309
29HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.84203013
30* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.80721796
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.80464848
32EZH2_22144423_ChIP-Seq_EOC_Human1.80410613
33PKCTHETA_26484144_Chip-Seq_BREAST_Human1.79041851
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.78828277
35IRF1_19129219_ChIP-ChIP_H3396_Human1.77524198
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74617136
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73312910
38TFEB_21752829_ChIP-Seq_HELA_Human1.72177443
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69196703
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67060004
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.67049362
42CIITA_25753668_ChIP-Seq_RAJI_Human1.62972446
43* GABP_19822575_ChIP-Seq_HepG2_Human1.59139014
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.58139466
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55967514
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55285989
47* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54159646
48* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53403664
49XRN2_22483619_ChIP-Seq_HELA_Human1.51892809
50FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.51025388
51ETS1_20019798_ChIP-Seq_JURKAT_Human1.50594470
52AR_21909140_ChIP-Seq_LNCAP_Human1.49528317
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49493036
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.49480760
55DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.47168334
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.44734137
57TP53_16413492_ChIP-PET_HCT116_Human1.44443001
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43627280
59EWS_26573619_Chip-Seq_HEK293_Human1.41754266
60GABP_17652178_ChIP-ChIP_JURKAT_Human1.41011617
61FUS_26573619_Chip-Seq_HEK293_Human1.38141637
62IGF1R_20145208_ChIP-Seq_DFB_Human1.34789121
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33578156
64E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.32841766
65ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30656119
66TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30451408
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27676932
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27477832
69ZNF274_21170338_ChIP-Seq_K562_Hela1.27429121
70ELK4_26923725_Chip-Seq_MESODERM_Mouse1.25657182
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.25224651
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24096104
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23650316
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23581554
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23188239
76* CHD1_26751641_Chip-Seq_LNCaP_Human1.22386662
77WT1_19549856_ChIP-ChIP_CCG9911_Human1.21168052
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.20446765
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16306637
80TTF2_22483619_ChIP-Seq_HELA_Human1.16226295
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16133450
82FOXP3_21729870_ChIP-Seq_TREG_Human1.15134586
83KDM2B_26808549_Chip-Seq_K562_Human1.13898905
84RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13543246
85RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13225707
86SOX9_26525672_Chip-Seq_HEART_Mouse1.13094112
87TCF4_18268006_ChIP-ChIP_LS174T_Human1.12422303
88KDM2B_26808549_Chip-Seq_DND41_Human1.11909926
89CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11417179
90TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.11410105
91NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.11379439
92STAT3_23295773_ChIP-Seq_U87_Human1.10929756
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10709737
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10709737
95MYC_22102868_ChIP-Seq_BL_Human1.10466306
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10261489
97MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09438383
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09133613
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09112073
100POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.06447334
101TP63_19390658_ChIP-ChIP_HaCaT_Human1.05911840
102SOX17_20123909_ChIP-Seq_XEN_Mouse1.05689115
103* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05016353
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04886134
105REST_21632747_ChIP-Seq_MESCs_Mouse1.03330873
106GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03002001
107SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01408936
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01216516
109TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01060718
110ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00645877
111ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00033053
112KDM2B_26808549_Chip-Seq_JURKAT_Human0.99669301
113CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99552744
114TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99318327
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98719858
116HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98078157
117REST_19997604_ChIP-ChIP_NEURONS_Mouse0.97536698
118CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97204339
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96733402
120GATA1_26923725_Chip-Seq_HPCs_Mouse0.96658740
121SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96344222
122TCF4_23295773_ChIP-Seq_U87_Human0.95107893
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94934007
124YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93864371
125WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93839671
126* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93246739
127SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92991088
128SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91859900
129SMAD_19615063_ChIP-ChIP_OVARY_Human0.90752814
130SMAD4_21799915_ChIP-Seq_A2780_Human0.89926722
131NANOG_21062744_ChIP-ChIP_HESCs_Human0.89373123
132GBX2_23144817_ChIP-Seq_PC3_Human0.88744400
133* AR_19668381_ChIP-Seq_PC3_Human0.87187038
134TCF7_22412390_ChIP-Seq_EML_Mouse0.86042794
135ZNF263_19887448_ChIP-Seq_K562_Human0.84725177
136RUNX1_26923725_Chip-Seq_HPCs_Mouse0.83208948
137ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82643400
138YAP1_20516196_ChIP-Seq_MESCs_Mouse0.82436742
139TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.82021321
140KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81240631
141ZFP281_18757296_ChIP-ChIP_E14_Mouse0.80686853
142ZNF217_24962896_ChIP-Seq_MCF-7_Human0.79251377
143KDM5A_27292631_Chip-Seq_BREAST_Human0.78449674
144TCF3_18692474_ChIP-Seq_MESCs_Mouse0.78348832
145CTBP2_25329375_ChIP-Seq_LNCAP_Human0.78251584
146PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.78008374
147AR_21572438_ChIP-Seq_LNCaP_Human0.77897168
148CTBP1_25329375_ChIP-Seq_LNCAP_Human0.77857216
149CTNNB1_20460455_ChIP-Seq_HCT116_Human0.77231917
150SOX2_21211035_ChIP-Seq_LN229_Gbm0.76864012
151P300_27058665_Chip-Seq_ZR-75-30cells_Human0.76275865
152* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.75631958
153PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.75225395
154BRD4_25478319_ChIP-Seq_HGPS_Human0.74752142
155REST_18959480_ChIP-ChIP_MESCs_Mouse0.73680789
156TBL1_22424771_ChIP-Seq_293T_Human0.72868747
157ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.72371113
158FOXO3_23340844_ChIP-Seq_DLD1_Human0.71440386
159NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.71183392
160FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.69605168

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.85268891
2MP0004859_abnormal_synaptic_plasticity3.41773648
3MP0003221_abnormal_cardiomyocyte_apopto3.20975088
4MP0010307_abnormal_tumor_latency3.01655548
5MP0000569_abnormal_digit_pigmentation2.79919213
6MP0003111_abnormal_nucleus_morphology2.61021447
7MP0005076_abnormal_cell_differentiation2.54320869
8MP0010094_abnormal_chromosome_stability2.49900068
9MP0003123_paternal_imprinting2.43413595
10MP0003787_abnormal_imprinting2.36549016
11MP0003890_abnormal_embryonic-extraembry2.09062866
12MP0001529_abnormal_vocalization2.06463406
13MP0003077_abnormal_cell_cycle2.05384588
14MP0009046_muscle_twitch2.05304628
15MP0003705_abnormal_hypodermis_morpholog1.92772814
16MP0002653_abnormal_ependyma_morphology1.91413554
17MP0001299_abnormal_eye_distance/1.90614456
18MP0010352_gastrointestinal_tract_polyps1.88762528
19MP0001730_embryonic_growth_arrest1.83735635
20MP0008961_abnormal_basal_metabolism1.82630813
21MP0001929_abnormal_gametogenesis1.81570404
22MP0008057_abnormal_DNA_replication1.81263132
23MP0003635_abnormal_synaptic_transmissio1.80689736
24MP0004270_analgesia1.80300136
25MP0008932_abnormal_embryonic_tissue1.77895603
26MP0009697_abnormal_copulation1.76367155
27MP0005394_taste/olfaction_phenotype1.74661883
28MP0005499_abnormal_olfactory_system1.74661883
29MP0000350_abnormal_cell_proliferation1.72098394
30MP0002084_abnormal_developmental_patter1.71652202
31MP0003693_abnormal_embryo_hatching1.69425868
32MP0003698_abnormal_male_reproductive1.62645871
33MP0003121_genomic_imprinting1.61128733
34MP0002210_abnormal_sex_determination1.56473691
35MP0010234_abnormal_vibrissa_follicle1.53936762
36MP0008007_abnormal_cellular_replicative1.53791804
37MP0005410_abnormal_fertilization1.51832054
38MP0008995_early_reproductive_senescence1.49548208
39MP0002085_abnormal_embryonic_tissue1.48881784
40MP0003091_abnormal_cell_migration1.48435640
41MP0000428_abnormal_craniofacial_morphol1.47252394
42MP0001145_abnormal_male_reproductive1.44916355
43MP0002063_abnormal_learning/memory/cond1.44326711
44MP0005380_embryogenesis_phenotype1.43601121
45MP0001672_abnormal_embryogenesis/_devel1.43601121
46MP0002234_abnormal_pharynx_morphology1.41689243
47MP0005187_abnormal_penis_morphology1.41017673
48MP0008058_abnormal_DNA_repair1.37961447
49MP0008789_abnormal_olfactory_epithelium1.37841418
50MP0004957_abnormal_blastocyst_morpholog1.37325485
51MP0001697_abnormal_embryo_size1.36527837
52MP0005623_abnormal_meninges_morphology1.35262461
53MP0004185_abnormal_adipocyte_glucose1.34059439
54MP0000653_abnormal_sex_gland1.32826636
55MP0003861_abnormal_nervous_system1.31510798
56MP0003984_embryonic_growth_retardation1.29361916
57MP0006276_abnormal_autonomic_nervous1.27786871
58MP0005423_abnormal_somatic_nervous1.25620886
59MP0002088_abnormal_embryonic_growth/wei1.24228925
60MP0003937_abnormal_limbs/digits/tail_de1.23683461
61MP0002086_abnormal_extraembryonic_tissu1.23295146
62MP0004197_abnormal_fetal_growth/weight/1.20549951
63MP0009703_decreased_birth_body1.18008937
64MP0004811_abnormal_neuron_physiology1.17468503
65MP0002102_abnormal_ear_morphology1.16005967
66MP0002877_abnormal_melanocyte_morpholog1.12306877
67MP0000647_abnormal_sebaceous_gland1.12203034
68MP0009780_abnormal_chondrocyte_physiolo1.10939389
69MP0001984_abnormal_olfaction1.10151400
70MP0002152_abnormal_brain_morphology1.09437082
71MP0004808_abnormal_hematopoietic_stem1.06849615
72MP0002161_abnormal_fertility/fecundity1.06376028
73MP0008260_abnormal_autophagy1.06007744
74MP0002233_abnormal_nose_morphology1.04134625
75MP0002080_prenatal_lethality1.03976945
76MP0004233_abnormal_muscle_weight1.03042451
77MP0005391_vision/eye_phenotype1.02545350
78MP0000778_abnormal_nervous_system1.02421851
79MP0006035_abnormal_mitochondrial_morpho1.02115025
80MP0003786_premature_aging1.01791066
81MP0002332_abnormal_exercise_endurance1.01786213
82MP0000358_abnormal_cell_content/1.01171582
83MP0002184_abnormal_innervation0.99681952
84MP0002064_seizures0.99522582
85MP0003718_maternal_effect0.98715082
86MP0003880_abnormal_central_pattern0.98193512
87MP0001849_ear_inflammation0.97695188
88MP0003935_abnormal_craniofacial_develop0.97317018
89MP0001286_abnormal_eye_development0.95802290
90MP0003045_fibrosis0.95709284
91MP0001915_intracranial_hemorrhage0.95162532
92MP0003300_gastrointestinal_ulcer0.94032228
93MP0000537_abnormal_urethra_morphology0.91841558
94MP0002098_abnormal_vibrissa_morphology0.91819217
95MP0009672_abnormal_birth_weight0.91379099
96MP0001502_abnormal_circadian_rhythm0.91349950
97MP0003385_abnormal_body_wall0.91122739
98MP0004885_abnormal_endolymph0.91107314
99MP0005621_abnormal_cell_physiology0.90924230
100MP0002009_preneoplasia0.89857809
101MP0009745_abnormal_behavioral_response0.89829798
102MP0000733_abnormal_muscle_development0.89363362
103MP0005253_abnormal_eye_physiology0.89164081
104MP0000955_abnormal_spinal_cord0.88774589
105MP0002751_abnormal_autonomic_nervous0.88675955
106MP0010678_abnormal_skin_adnexa0.88456968
107MP0002177_abnormal_outer_ear0.88094101
108MP0005501_abnormal_skin_physiology0.88057045
109MP0005451_abnormal_body_composition0.87996998
110MP0003283_abnormal_digestive_organ0.87965680
111MP0003115_abnormal_respiratory_system0.87843582
112MP0005266_abnormal_metabolism0.86744335
113MP0002090_abnormal_vision0.86243701
114MP0001486_abnormal_startle_reflex0.85978743
115MP0003941_abnormal_skin_development0.85519688
116MP0008770_decreased_survivor_rate0.85332935
117MP0000631_abnormal_neuroendocrine_gland0.84687304
118MP0002572_abnormal_emotion/affect_behav0.83670832
119MP0001727_abnormal_embryo_implantation0.82734641
120MP0002822_catalepsy0.80788503
121MP0002882_abnormal_neuron_morphology0.80786134
122MP0001293_anophthalmia0.80551864
123MP0002081_perinatal_lethality0.80175874
124MP0002638_abnormal_pupillary_reflex0.79248158
125MP0003755_abnormal_palate_morphology0.78793004
126MP0002269_muscular_atrophy0.77196637
127MP0003632_abnormal_nervous_system0.76427552
128MP0000013_abnormal_adipose_tissue0.76361705
129MP0005367_renal/urinary_system_phenotyp0.76338840
130MP0000516_abnormal_urinary_system0.76338840
131MP0005384_cellular_phenotype0.75641512
132MP0002697_abnormal_eye_size0.74126849
133MP0005257_abnormal_intraocular_pressure0.74090613
134MP0003119_abnormal_digestive_system0.73738941
135MP0005248_abnormal_Harderian_gland0.73687201
136MP0000313_abnormal_cell_death0.73588041
137MP0003699_abnormal_female_reproductive0.72954400
138MP0002909_abnormal_adrenal_gland0.72842594
139MP0002092_abnormal_eye_morphology0.72605598
140MP0002734_abnormal_mechanical_nocicepti0.71907489
141MP0000432_abnormal_head_morphology0.70591686
142MP0009278_abnormal_bone_marrow0.70456932

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)3.90026207
2Facial hemangioma (HP:0000329)3.78031483
3Hyperacusis (HP:0010780)3.53207148
4Renovascular hypertension (HP:0100817)3.39111138
5Entropion (HP:0000621)3.34956422
6Elfin facies (HP:0004428)3.33703056
7Medulloblastoma (HP:0002885)3.19623988
8Abnormality of the lower motor neuron (HP:0002366)3.18842716
9Overriding aorta (HP:0002623)3.17848271
10Abnormality of the hip-girdle musculature (HP:0001445)3.01969994
11Abnormality of the musculature of the pelvis (HP:0001469)3.01969994
12Heterotopia (HP:0002282)3.01793850
13Papillary thyroid carcinoma (HP:0002895)2.96154630
14Abnormality of the labia minora (HP:0012880)2.95148893
15Insomnia (HP:0100785)2.89070567
16Shoulder girdle muscle weakness (HP:0003547)2.70501593
17Renal duplication (HP:0000075)2.70053683
18Poikiloderma (HP:0001029)2.69946655
19Astrocytoma (HP:0009592)2.66756218
20Abnormality of the astrocytes (HP:0100707)2.66756218
21Bowel diverticulosis (HP:0005222)2.66146368
22Scanning speech (HP:0002168)2.56078725
23Flat cornea (HP:0007720)2.55727087
24Increased nuchal translucency (HP:0010880)2.51452062
25Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.50273174
26Tubulointerstitial nephritis (HP:0001970)2.48589246
27Congenital primary aphakia (HP:0007707)2.43385241
28Abnormality of the diencephalon (HP:0010662)2.42089955
29Nephrogenic diabetes insipidus (HP:0009806)2.40421693
30Short tibia (HP:0005736)2.38773530
31Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.36874263
32Short 4th metacarpal (HP:0010044)2.36874263
33Pointed chin (HP:0000307)2.36638501
34Poor coordination (HP:0002370)2.33768002
35Gait imbalance (HP:0002141)2.33605808
36Deep philtrum (HP:0002002)2.31742210
37Exercise-induced muscle cramps (HP:0003710)2.30365792
38Impaired smooth pursuit (HP:0007772)2.30117339
39Focal seizures (HP:0007359)2.27089164
40Truncal ataxia (HP:0002078)2.26963193
41Aplasia/Hypoplasia of the tibia (HP:0005772)2.25850516
42Focal motor seizures (HP:0011153)2.25314414
43Ependymoma (HP:0002888)2.24906843
44Obsessive-compulsive behavior (HP:0000722)2.24236479
45Oligodactyly (hands) (HP:0001180)2.24179764
46Sandal gap (HP:0001852)2.23256363
47Uterine leiomyosarcoma (HP:0002891)2.20421613
48Leiomyosarcoma (HP:0100243)2.20421613
49Overlapping toe (HP:0001845)2.18153105
50Hepatoblastoma (HP:0002884)2.17770723
51Abnormality of ocular smooth pursuit (HP:0000617)2.16822015
52Male infertility (HP:0003251)2.14043396
53Bladder carcinoma (HP:0002862)2.13601247
54Bladder neoplasm (HP:0009725)2.13601247
55Macroorchidism (HP:0000053)2.09695325
56Bladder diverticulum (HP:0000015)2.09530698
57Abnormality of the metopic suture (HP:0005556)2.08727832
58Oligodactyly (HP:0012165)2.07351749
59Megalocornea (HP:0000485)2.06180919
60Volvulus (HP:0002580)2.03396795
61Freckling (HP:0001480)2.03305671
62Urinary bladder sphincter dysfunction (HP:0002839)2.03182395
63Microglossia (HP:0000171)2.01789176
64Absent eyebrow (HP:0002223)2.01724523
65Glossoptosis (HP:0000162)2.01035514
66Glioma (HP:0009733)2.00867235
67Microvesicular hepatic steatosis (HP:0001414)1.99365707
68Postnatal microcephaly (HP:0005484)1.99131130
69Curly hair (HP:0002212)1.98390401
70High anterior hairline (HP:0009890)1.97980301
71Nephroblastoma (Wilms tumor) (HP:0002667)1.97037262
72Prominent nose (HP:0000448)1.95901313
73Abnormality of the carotid arteries (HP:0005344)1.95662662
74Progressive sensorineural hearing impairment (HP:0000408)1.95522719
75Abnormality of the fingertips (HP:0001211)1.94981994
76Hypopigmentation of the fundus (HP:0007894)1.94010717
77Narrow palate (HP:0000189)1.93755510
78Proximal placement of thumb (HP:0009623)1.92661545
79Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.91947468
80Termporal pattern (HP:0011008)1.91162091
81Insidious onset (HP:0003587)1.91162091
82Enlarged penis (HP:0000040)1.90988718
83Truncal obesity (HP:0001956)1.90802829
84Prominent metopic ridge (HP:0005487)1.89753168
85Ectropion (HP:0000656)1.89430054
86Shallow orbits (HP:0000586)1.88543607
87Ankyloglossia (HP:0010296)1.88165363
88Urethral obstruction (HP:0000796)1.87838551
89Open mouth (HP:0000194)1.87613520
90Chronic hepatic failure (HP:0100626)1.86521579
91Cutaneous melanoma (HP:0012056)1.86493982
92Impaired vibration sensation in the lower limbs (HP:0002166)1.86299771
93Birth length less than 3rd percentile (HP:0003561)1.86215286
94Capillary hemangiomas (HP:0005306)1.85762188
95Large earlobe (HP:0009748)1.85733224
96Septate vagina (HP:0001153)1.85336911
97Spastic gait (HP:0002064)1.85056691
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.84679216
99Subacute progressive viral hepatitis (HP:0006572)1.84554581
100Hypoplastic labia majora (HP:0000059)1.83154410
101Embryonal renal neoplasm (HP:0011794)1.82852933
102Deviation of the thumb (HP:0009603)1.82528851
103Sacral dimple (HP:0000960)1.82393979
104Menstrual irregularities (HP:0000858)1.81997535
105Facial cleft (HP:0002006)1.81571423
106Medial flaring of the eyebrow (HP:0010747)1.79156622
107Urinary urgency (HP:0000012)1.78450140
108Chromosomal breakage induced by crosslinking agents (HP:0003221)1.77685417
109Amyotrophic lateral sclerosis (HP:0007354)1.77272143
110Cerebral aneurysm (HP:0004944)1.77150963
111Lissencephaly (HP:0001339)1.76695355
112Rhabdomyosarcoma (HP:0002859)1.76410365
113Genetic anticipation (HP:0003743)1.75033707
114Failure to thrive in infancy (HP:0001531)1.74405075
115Aqueductal stenosis (HP:0002410)1.74219972
116Hypsarrhythmia (HP:0002521)1.74167946
117Ankle contracture (HP:0006466)1.73759572
118Abnormality of chromosome stability (HP:0003220)1.73232908
119Thyroid carcinoma (HP:0002890)1.72436090
120Spastic diplegia (HP:0001264)1.72416733
121Decreased testicular size (HP:0008734)1.71132788
122Long eyelashes (HP:0000527)1.70583050
123EEG with generalized epileptiform discharges (HP:0011198)1.70266262
124Dysmetric saccades (HP:0000641)1.69065425
125Specific learning disability (HP:0001328)1.66929426
126Genu recurvatum (HP:0002816)1.65095424
127Neoplasm of the oral cavity (HP:0100649)1.64762173
128Abnormality of oral frenula (HP:0000190)1.63995070
129Genital tract atresia (HP:0001827)1.63394928
130Aplasia/Hypoplasia of the sternum (HP:0006714)1.62980416
131Deep palmar crease (HP:0006191)1.62975298
132Vaginal atresia (HP:0000148)1.62791698
133Sensory axonal neuropathy (HP:0003390)1.62310226
134Hammertoe (HP:0001765)1.62285362
135Attention deficit hyperactivity disorder (HP:0007018)1.61928523
136Atonic seizures (HP:0010819)1.61532418
137Autoamputation (HP:0001218)1.61415681
138Broad thumb (HP:0011304)1.61397915
139Abnormality of the labia majora (HP:0012881)1.61093073
140Spina bifida occulta (HP:0003298)1.60489985
141Patellar dislocation (HP:0002999)1.60395042
142Cafe-au-lait spot (HP:0000957)1.60143450
143Aplasia/Hypoplasia of the brainstem (HP:0007362)1.60091463
144Hypoplasia of the brainstem (HP:0002365)1.60091463
145Epileptiform EEG discharges (HP:0011182)1.60013890
146Pheochromocytoma (HP:0002666)1.59342228
147Malignant neoplasm of the central nervous system (HP:0100836)1.58977509
148Spastic paraplegia (HP:0001258)1.58976293
149Broad nasal tip (HP:0000455)1.57895489
150Hypoplastic toenails (HP:0001800)1.57807830
151Lower limb muscle weakness (HP:0007340)1.57657835
152Sparse lateral eyebrow (HP:0005338)1.57534262
153Trigonocephaly (HP:0000243)1.56745802
154Breast aplasia (HP:0100783)1.56541207
155Abnormality of the 4th metacarpal (HP:0010012)1.56088321
156Complete atrioventricular canal defect (HP:0001674)1.55858009
157Action tremor (HP:0002345)1.55566313
158Shawl scrotum (HP:0000049)1.54984969
159Abnormality of the corticospinal tract (HP:0002492)1.54782620
160Pes planus (HP:0001763)1.53776615
161Gastrointestinal carcinoma (HP:0002672)1.53231372
162Malignant gastrointestinal tract tumors (HP:0006749)1.53231372
163Resting tremor (HP:0002322)1.52874740
164Hallux valgus (HP:0001822)1.52145159
165Absent frontal sinuses (HP:0002688)1.51778304
166Excessive salivation (HP:0003781)1.51660443
167Drooling (HP:0002307)1.51660443
168Visual hallucinations (HP:0002367)1.50591565
169Transitional cell carcinoma of the bladder (HP:0006740)1.48220419
170Broad phalanges of the hand (HP:0009768)1.47554634
171Abnormality of chromosome segregation (HP:0002916)1.47309953
172Pelvic girdle muscle weakness (HP:0003749)1.47282308
173Progressive cerebellar ataxia (HP:0002073)1.46864424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.88631608
2LATS13.74604197
3BCR3.33777422
4LATS23.32859843
5MAP3K93.24325941
6TRIM282.78951262
7CDC72.75796402
8ERBB32.54304570
9CSNK1A1L2.36031375
10MAP3K42.25068259
11KSR12.23413663
12NEK22.19761667
13CSNK1G32.07236741
14NTRK31.99897568
15PIM21.95457766
16CASK1.94238064
17PBK1.92460844
18SCYL21.87486182
19CSNK1G11.87111283
20STK31.86049536
21PAK61.85720310
22EIF2AK31.81556210
23CSNK1G21.70122678
24KSR21.69246768
25TSSK61.66331699
26STK381.65849918
27CDK61.65258158
28PRKD31.62380487
29BUB11.60710476
30RPS6KA41.58726082
31EPHA31.51232996
32TAOK11.51069116
33BRSK21.48553730
34DYRK1B1.45105464
35PDK31.45088986
36PDK41.45088986
37WEE11.44865746
38STK38L1.39777700
39MELK1.38533196
40TYRO31.34378337
41PDGFRB1.34224466
42BRD41.30949863
43NTRK21.26434255
44NEK11.20933489
45EPHA41.20018365
46BRSK11.16891895
47FRK1.16804612
48MAP4K21.15186594
49EEF2K1.14164627
50CHEK21.13604357
51PDGFRA1.13115722
52CAMK1D1.11560209
53NEK91.10069194
54ALK1.06898554
55RPS6KA51.05003755
56CHEK11.04426687
57NTRK11.04083659
58MTOR1.03870809
59SRPK11.03714157
60PKN21.02049187
61CAMKK21.01952122
62ACVR1B1.00300829
63RIPK11.00295378
64NEK61.00067477
65SGK30.99139260
66MARK10.98851890
67SGK20.97957749
68TTK0.97316150
69PLK10.95801427
70RAF10.95612812
71CCNB10.95090093
72MAP3K20.94727293
73SIK30.94380350
74PLK40.91716283
75CAMK40.91044252
76MINK10.90795140
77CAMKK10.86996223
78DYRK30.86582697
79CDK90.86008990
80DDR20.84980861
81RET0.83178126
82FER0.82791308
83STK110.82731822
84AURKA0.81734289
85MAPK100.81593415
86AKT30.81287926
87TRIB30.80662768
88CAMK1G0.78825229
89FGFR20.78365536
90AURKB0.78344783
91PLK30.78279102
92CDK20.77127562
93ATM0.75091547
94VRK10.73337232
95UHMK10.73307512
96PRPF4B0.72844474
97BCKDK0.70623851
98TLK10.70331326
99SGK2230.69778766
100SGK4940.69778766
101ATR0.68328677
102CDK10.67479709
103BRAF0.67384622
104DMPK0.67168615
105MAP2K40.66989377
106TESK20.61632085
107RPS6KB10.61052141
108ERBB40.60519513
109PIM10.59914797
110PRKAA10.59664906
111EIF2AK10.59518828
112MAP3K100.59244569
113MARK30.59052159
114ICK0.58284995
115MAP2K70.56827698
116MARK20.56459619
117PDK20.56317401
118CDK40.55907827
119CDK140.54212633
120SGK10.53875375
121PAK30.53459001
122PLK20.52730365
123CDK70.52618931
124DYRK1A0.52348425
125CDK30.50823212
126GSK3B0.49908833
127ZAK0.49300306
128RPS6KA30.49078529
129LMTK20.48643900
130CSNK1D0.46813388
131CSNK1E0.45687762
132MAP3K60.45517273
133PNCK0.45211148
134MAPK140.44054845
135PRKDC0.43448541
136MAP3K80.42387571
137CDK50.41358736
138YES10.41210359
139CDK180.39935819
140TTN0.39019432
141AKT20.38909061
142MAPK80.38866552
143MAP3K50.38192837
144PDK10.37923689
145PAK20.37836063
146MAPK110.33582356
147BMPR20.33556413
148CDK150.32567368
149MST1R0.32144022
150WNK30.31971795
151MAPK90.30984567

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38614544
2DNA replication_Homo sapiens_hsa030302.25719877
3Steroid biosynthesis_Homo sapiens_hsa001002.24353588
4Non-homologous end-joining_Homo sapiens_hsa034501.87009952
5Oocyte meiosis_Homo sapiens_hsa041141.84752407
6Mismatch repair_Homo sapiens_hsa034301.84364976
7Spliceosome_Homo sapiens_hsa030401.83528960
8Long-term potentiation_Homo sapiens_hsa047201.81544522
9Cell cycle_Homo sapiens_hsa041101.74088785
10mTOR signaling pathway_Homo sapiens_hsa041501.73464668
11Systemic lupus erythematosus_Homo sapiens_hsa053221.67414688
12Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.65441981
13Dorso-ventral axis formation_Homo sapiens_hsa043201.59596639
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.56722079
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55098409
16Nicotine addiction_Homo sapiens_hsa050331.54788800
17Alcoholism_Homo sapiens_hsa050341.51792985
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.50870026
19Phosphatidylinositol signaling system_Homo sapiens_hsa040701.50504521
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46384740
21RNA transport_Homo sapiens_hsa030131.46168953
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.44528454
23Glioma_Homo sapiens_hsa052141.42109021
24Amphetamine addiction_Homo sapiens_hsa050311.41812737
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40857472
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.36646728
27Type II diabetes mellitus_Homo sapiens_hsa049301.35567114
28Thyroid hormone signaling pathway_Homo sapiens_hsa049191.33806460
29Biosynthesis of amino acids_Homo sapiens_hsa012301.33561356
30Estrogen signaling pathway_Homo sapiens_hsa049151.32923150
31mRNA surveillance pathway_Homo sapiens_hsa030151.32319068
32Nucleotide excision repair_Homo sapiens_hsa034201.31274093
33ErbB signaling pathway_Homo sapiens_hsa040121.30263227
34MicroRNAs in cancer_Homo sapiens_hsa052061.24575542
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21188155
36Circadian entrainment_Homo sapiens_hsa047131.20575737
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.19291949
38Endometrial cancer_Homo sapiens_hsa052131.18230619
39Dopaminergic synapse_Homo sapiens_hsa047281.17963508
40Colorectal cancer_Homo sapiens_hsa052101.17851854
41Chronic myeloid leukemia_Homo sapiens_hsa052201.16906587
42Glutamatergic synapse_Homo sapiens_hsa047241.14839960
43Base excision repair_Homo sapiens_hsa034101.14581157
44GnRH signaling pathway_Homo sapiens_hsa049121.12591249
45Non-small cell lung cancer_Homo sapiens_hsa052231.10339210
46Olfactory transduction_Homo sapiens_hsa047401.10107619
47Longevity regulating pathway - mammal_Homo sapiens_hsa042111.09129975
48Vitamin B6 metabolism_Homo sapiens_hsa007501.08220649
49Renal cell carcinoma_Homo sapiens_hsa052111.08120870
50Gastric acid secretion_Homo sapiens_hsa049711.07792481
51Oxytocin signaling pathway_Homo sapiens_hsa049211.07677926
52Salivary secretion_Homo sapiens_hsa049701.07526493
53Insulin secretion_Homo sapiens_hsa049111.06652877
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06184019
55Inositol phosphate metabolism_Homo sapiens_hsa005621.05717344
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.05594910
57Vibrio cholerae infection_Homo sapiens_hsa051101.04980313
58Fatty acid biosynthesis_Homo sapiens_hsa000611.04262739
59Synaptic vesicle cycle_Homo sapiens_hsa047211.04133328
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03826178
61Viral carcinogenesis_Homo sapiens_hsa052031.02732007
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00122131
63Basal transcription factors_Homo sapiens_hsa030220.99997821
64Fanconi anemia pathway_Homo sapiens_hsa034600.99879725
65Adherens junction_Homo sapiens_hsa045200.99270595
66Cholinergic synapse_Homo sapiens_hsa047250.98659263
67Circadian rhythm_Homo sapiens_hsa047100.98369697
68Gap junction_Homo sapiens_hsa045400.98062547
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97905141
70GABAergic synapse_Homo sapiens_hsa047270.94895896
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.94884317
72Hippo signaling pathway_Homo sapiens_hsa043900.94688179
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93545501
74Choline metabolism in cancer_Homo sapiens_hsa052310.92707926
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92308349
76Morphine addiction_Homo sapiens_hsa050320.90752362
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.90380945
78Regulation of autophagy_Homo sapiens_hsa041400.90209174
79Glucagon signaling pathway_Homo sapiens_hsa049220.89140502
80TGF-beta signaling pathway_Homo sapiens_hsa043500.88909939
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88696273
82Lysine degradation_Homo sapiens_hsa003100.88252331
83Renin secretion_Homo sapiens_hsa049240.87259058
84Nitrogen metabolism_Homo sapiens_hsa009100.87203520
85FoxO signaling pathway_Homo sapiens_hsa040680.86283496
86Long-term depression_Homo sapiens_hsa047300.85762421
87Cocaine addiction_Homo sapiens_hsa050300.84599603
88Pancreatic cancer_Homo sapiens_hsa052120.84526402
89cAMP signaling pathway_Homo sapiens_hsa040240.83747184
90Melanogenesis_Homo sapiens_hsa049160.83284422
91Prolactin signaling pathway_Homo sapiens_hsa049170.83116502
92p53 signaling pathway_Homo sapiens_hsa041150.81745801
93Hepatitis B_Homo sapiens_hsa051610.81225428
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.80928726
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80762778
96Carbon metabolism_Homo sapiens_hsa012000.79888352
97Axon guidance_Homo sapiens_hsa043600.78839076
98Pentose phosphate pathway_Homo sapiens_hsa000300.78687494
99Wnt signaling pathway_Homo sapiens_hsa043100.77398971
100Insulin signaling pathway_Homo sapiens_hsa049100.77361890
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77190470
102VEGF signaling pathway_Homo sapiens_hsa043700.75573489
103Proteoglycans in cancer_Homo sapiens_hsa052050.75268924
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73924667
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73514013
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72977933
107MAPK signaling pathway_Homo sapiens_hsa040100.72720953
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72345863
109Small cell lung cancer_Homo sapiens_hsa052220.71824126
110Prostate cancer_Homo sapiens_hsa052150.71271628
111Thyroid hormone synthesis_Homo sapiens_hsa049180.70945284
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67015607
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65089988
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64598089
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64187755
116Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62184058
117AMPK signaling pathway_Homo sapiens_hsa041520.61422931
118Endocytosis_Homo sapiens_hsa041440.60662732
119Thyroid cancer_Homo sapiens_hsa052160.60631107
120HTLV-I infection_Homo sapiens_hsa051660.60155444
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.59768354
122Focal adhesion_Homo sapiens_hsa045100.58911791
123Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58760078
124Calcium signaling pathway_Homo sapiens_hsa040200.58650944
125RNA degradation_Homo sapiens_hsa030180.58119732
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57688886
127Bladder cancer_Homo sapiens_hsa052190.56678750
128RNA polymerase_Homo sapiens_hsa030200.55010454
129Propanoate metabolism_Homo sapiens_hsa006400.54118018
130Selenocompound metabolism_Homo sapiens_hsa004500.53280567
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53279296
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53274440
133Shigellosis_Homo sapiens_hsa051310.52060393
134Taste transduction_Homo sapiens_hsa047420.51571023
135Epstein-Barr virus infection_Homo sapiens_hsa051690.51402651
136Melanoma_Homo sapiens_hsa052180.50404250
137Pyrimidine metabolism_Homo sapiens_hsa002400.46580587
138Hedgehog signaling pathway_Homo sapiens_hsa043400.46294658
139HIF-1 signaling pathway_Homo sapiens_hsa040660.45543837
140Cysteine and methionine metabolism_Homo sapiens_hsa002700.45130392
141Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41581910
142Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40473334
143Apoptosis_Homo sapiens_hsa042100.39961157
144Fatty acid elongation_Homo sapiens_hsa000620.38307362
145Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37791434

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