KLHL17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is expressed in neurons of most regions of the brain. It contains an N-terminal BTB domain, which mediates dimerization of the protein, and a C-terminal Kelch domain, which mediates binding to F-actin. This protein may play a key role in the regulation of actin-based neuronal function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)4.99457067
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.67994129
3negative regulation of erythrocyte differentiation (GO:0045647)4.64147321
4synaptic vesicle maturation (GO:0016188)4.56988392
5proline biosynthetic process (GO:0006561)4.54180663
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.48399585
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.42825822
8regulation of mammary gland epithelial cell proliferation (GO:0033599)4.32607578
9neuron cell-cell adhesion (GO:0007158)4.32338837
10central nervous system myelination (GO:0022010)4.32134513
11axon ensheathment in central nervous system (GO:0032291)4.32134513
12COPI coating of Golgi vesicle (GO:0048205)4.19376949
13Golgi transport vesicle coating (GO:0048200)4.19376949
14apoptotic process involved in morphogenesis (GO:0060561)4.14192860
15vocalization behavior (GO:0071625)4.07664197
16synaptic vesicle exocytosis (GO:0016079)4.06528305
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.06324131
18dendritic spine morphogenesis (GO:0060997)4.05860749
19activation of Rac GTPase activity (GO:0032863)4.03897772
20mitotic chromosome condensation (GO:0007076)4.03604531
21planar cell polarity pathway involved in neural tube closure (GO:0090179)3.97111170
22ionotropic glutamate receptor signaling pathway (GO:0035235)3.92855757
23layer formation in cerebral cortex (GO:0021819)3.92296669
24regulation of translational fidelity (GO:0006450)3.91721716
25neuronal action potential propagation (GO:0019227)3.89077633
26regulation of synaptic vesicle exocytosis (GO:2000300)3.86331297
27DNA unwinding involved in DNA replication (GO:0006268)3.74848089
28regulation of glutamate receptor signaling pathway (GO:1900449)3.70901520
29cell-cell junction maintenance (GO:0045217)3.70293755
30transmission of nerve impulse (GO:0019226)3.68336525
31mannose metabolic process (GO:0006013)3.65950051
32neuron recognition (GO:0008038)3.65782574
33regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.65100504
34negative regulation of cell size (GO:0045792)3.63995955
35heterochromatin organization (GO:0070828)3.61828785
36pattern specification involved in kidney development (GO:0061004)3.61289499
37glutamate secretion (GO:0014047)3.60982857
38protein localization to synapse (GO:0035418)3.59173843
39glutamate receptor signaling pathway (GO:0007215)3.58915763
40nuclear pore complex assembly (GO:0051292)3.54582349
41neurotransmitter secretion (GO:0007269)3.54107141
42neuronal ion channel clustering (GO:0045161)3.50276884
43cellular potassium ion homeostasis (GO:0030007)3.49264699
44exploration behavior (GO:0035640)3.47937975
45semaphorin-plexin signaling pathway (GO:0071526)3.44093997
46adherens junction assembly (GO:0034333)3.42521832
47axonal fasciculation (GO:0007413)3.42158953
48synaptic transmission, glutamatergic (GO:0035249)3.39580586
49mating behavior (GO:0007617)3.38873312
50peptidyl-arginine omega-N-methylation (GO:0035247)3.38351496
51regulation of neuronal synaptic plasticity (GO:0048168)3.37797872
52focal adhesion assembly (GO:0048041)3.35507494
53cell-substrate adherens junction assembly (GO:0007045)3.35507494
54dendrite morphogenesis (GO:0048813)3.34713680
55spliceosomal tri-snRNP complex assembly (GO:0000244)3.32873155
56retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.32095177
57gamma-aminobutyric acid transport (GO:0015812)3.31271689
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31196839
59negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.31172539
60response to pheromone (GO:0019236)3.30827527
61regulation of synaptic vesicle transport (GO:1902803)3.29699446
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.25368853
63regulation of long-term neuronal synaptic plasticity (GO:0048169)3.25080269
64regulation of early endosome to late endosome transport (GO:2000641)3.24468525
65regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.24017351
66postsynaptic membrane organization (GO:0001941)3.23050616
67long-term memory (GO:0007616)3.22801368
68L-amino acid import (GO:0043092)3.22635691
69neuron-neuron synaptic transmission (GO:0007270)3.18430043
70protein retention in ER lumen (GO:0006621)3.15440525
71maternal placenta development (GO:0001893)3.15072111
72proline metabolic process (GO:0006560)3.15059151
73regulation of NFAT protein import into nucleus (GO:0051532)3.14916704
74cerebellar Purkinje cell differentiation (GO:0021702)3.13261384
75striatum development (GO:0021756)3.13183983
76regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.11777367
77DNA topological change (GO:0006265)3.11604826
78regulation of histone H3-K27 methylation (GO:0061085)3.10205383
79presynaptic membrane assembly (GO:0097105)3.10020428
80regulation of excitatory postsynaptic membrane potential (GO:0060079)3.08516364
81maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.08194517
82adult walking behavior (GO:0007628)3.07246207
83regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.06852815
84positive regulation of membrane potential (GO:0045838)3.04688242
85neurotransmitter transport (GO:0006836)3.03453328
86synaptic vesicle docking involved in exocytosis (GO:0016081)3.02288031
87regulation of chromatin binding (GO:0035561)3.02282072
88sodium ion export (GO:0071436)3.02005967
89gamma-aminobutyric acid signaling pathway (GO:0007214)3.01762709
90positive regulation of histone deacetylation (GO:0031065)3.01665319
91membrane depolarization during action potential (GO:0086010)3.00982990
92histone H4 deacetylation (GO:0070933)2.99832283
93regulation of RNA export from nucleus (GO:0046831)2.99708102
94presynaptic membrane organization (GO:0097090)2.99644090
95protein localization to endosome (GO:0036010)2.99337236
96suckling behavior (GO:0001967)2.99139317
97activation of protein kinase A activity (GO:0034199)2.99013237
98positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.98955235
99regulation of synapse structural plasticity (GO:0051823)2.97935382
100regulation of postsynaptic membrane potential (GO:0060078)2.97579049
101membrane hyperpolarization (GO:0060081)2.95514454
102regulation of ARF GTPase activity (GO:0032312)2.95419379
103nerve growth factor signaling pathway (GO:0038180)2.95226607
104neuromuscular process controlling balance (GO:0050885)2.94032581
105G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.91873192
106cerebellar granule cell differentiation (GO:0021707)2.91285869
107neurotransmitter-gated ion channel clustering (GO:0072578)2.91189464
108myelination (GO:0042552)2.91036985
109cell migration in hindbrain (GO:0021535)2.90498706
110regulation of ARF protein signal transduction (GO:0032012)2.90344975
111negative regulation of cytosolic calcium ion concentration (GO:0051481)2.90177306
112establishment of apical/basal cell polarity (GO:0035089)2.89881043
113potassium ion homeostasis (GO:0055075)2.89722446
114pentose-phosphate shunt (GO:0006098)2.88972587
115regulation of dendritic spine morphogenesis (GO:0061001)2.88947945
116membrane depolarization (GO:0051899)2.86167670
117axon ensheathment (GO:0008366)2.85703319
118ensheathment of neurons (GO:0007272)2.85703319
119activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.85580555
120basement membrane organization (GO:0071711)2.85476659
121regulation of glucose import in response to insulin stimulus (GO:2001273)2.84587567
122snRNA metabolic process (GO:0016073)2.81310810
123cell-substrate junction assembly (GO:0007044)2.81099015
124apoptotic process involved in development (GO:1902742)2.80704888
125positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.80412708
126positive regulation of nuclease activity (GO:0032075)2.80299150
127neural tube development (GO:0021915)2.80219259
128regulation of voltage-gated calcium channel activity (GO:1901385)2.79711399
129negative regulation of axon extension (GO:0030517)2.79614506
130long-term synaptic potentiation (GO:0060291)2.79256570
131positive regulation of synapse maturation (GO:0090129)2.79256463
132mitotic G1 DNA damage checkpoint (GO:0031571)2.79148263
133cellular protein complex localization (GO:0034629)2.78172720
134intracellular estrogen receptor signaling pathway (GO:0030520)2.77894635
135synaptic vesicle endocytosis (GO:0048488)2.77363551
136regulation of vesicle fusion (GO:0031338)2.76782891
137regulation of neurotransmitter levels (GO:0001505)2.76275560
138nuclear pore organization (GO:0006999)2.75877305
139glucose catabolic process (GO:0006007)2.75743021
140synapse organization (GO:0050808)2.75177229
141negative regulation of axonogenesis (GO:0050771)2.74634497
142prepulse inhibition (GO:0060134)2.73960979
143establishment of nucleus localization (GO:0040023)2.73298326
144regulation of synaptic transmission, glutamatergic (GO:0051966)2.72226499
145peptidyl-arginine N-methylation (GO:0035246)2.71857527
146peptidyl-arginine methylation (GO:0018216)2.71857527
147atrioventricular valve morphogenesis (GO:0003181)2.71619513
148convergent extension (GO:0060026)2.71286637
149negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.70787337
150positive regulation of synaptic transmission, GABAergic (GO:0032230)2.70712995
151positive regulation of synapse assembly (GO:0051965)2.70621888
152positive regulation of dendritic spine development (GO:0060999)2.70496940
153mitotic G1/S transition checkpoint (GO:0044819)2.70295484
154embryonic process involved in female pregnancy (GO:0060136)2.70163840
155stress granule assembly (GO:0034063)2.69774875
156regulation of nucleobase-containing compound transport (GO:0032239)2.68366330
157glycine transport (GO:0015816)2.68170554
158UV protection (GO:0009650)2.67628706
159regulation of synaptic plasticity (GO:0048167)2.66763805
160negative regulation of viral release from host cell (GO:1902187)2.65555528
161synapse assembly (GO:0007416)2.64862692
162negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.64858871
163positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.62617782
164neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.62118999
165positive regulation of potassium ion transmembrane transport (GO:1901381)2.62059990
166cytoskeletal anchoring at plasma membrane (GO:0007016)2.62002219
167regulation of neurotransmitter secretion (GO:0046928)2.61690196
168DNA replication initiation (GO:0006270)2.61172305
1693-UTR-mediated mRNA stabilization (GO:0070935)2.60614382
170protein export from nucleus (GO:0006611)2.58510970
171pore complex assembly (GO:0046931)2.58269656
172protein complex localization (GO:0031503)2.58067941
173positive regulation of blood vessel endothelial cell migration (GO:0043536)2.57702285
174cellular response to epidermal growth factor stimulus (GO:0071364)2.57132647
175modulation by virus of host process (GO:0019054)2.57077961
176negative regulation of mRNA metabolic process (GO:1903312)2.55314194
177positive regulation of DNA-dependent DNA replication (GO:2000105)2.54966148
178RNA stabilization (GO:0043489)2.53660757
179mRNA stabilization (GO:0048255)2.53660757
180G1 DNA damage checkpoint (GO:0044783)2.53579305
181protein-DNA complex disassembly (GO:0032986)2.53535778
182nucleosome disassembly (GO:0006337)2.53535778
183glucose 6-phosphate metabolic process (GO:0051156)2.52687921
184regulation of nuclease activity (GO:0032069)2.52532622
185mitotic sister chromatid segregation (GO:0000070)2.51878830
186epithelial cell-cell adhesion (GO:0090136)2.51692336
187chromosome condensation (GO:0030261)2.50693489
188negative regulation of DNA-templated transcription, elongation (GO:0032785)2.50544358
189histone H3-K9 demethylation (GO:0033169)2.50212752
190regulation of mitotic spindle organization (GO:0060236)2.49696185
191histone arginine methylation (GO:0034969)2.49127318
192DNA duplex unwinding (GO:0032508)2.48636626
193establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.48134549
194mitochondrion transport along microtubule (GO:0047497)2.48134549
195ribosomal small subunit biogenesis (GO:0042274)2.47526095
196cochlea morphogenesis (GO:0090103)2.47474423
197negative regulation of mRNA processing (GO:0050686)2.46379839
198endoplasmic reticulum unfolded protein response (GO:0030968)2.44914468
199activation of MAPKKK activity (GO:0000185)2.44267588
200peptidyl-lysine dimethylation (GO:0018027)2.43699768

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.43396878
2E2F7_22180533_ChIP-Seq_HELA_Human3.53158062
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10421521
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.07247415
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02674986
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95064138
7MYC_22102868_ChIP-Seq_BL_Human2.91723818
8DROSHA_22980978_ChIP-Seq_HELA_Human2.86281940
9GBX2_23144817_ChIP-Seq_PC3_Human2.77874078
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.77661862
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.77661862
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.73043678
13VDR_21846776_ChIP-Seq_THP-1_Human2.71621443
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.66448722
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.60412080
16LXR_22292898_ChIP-Seq_THP-1_Human2.58375798
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51722930
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.50967768
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.49928697
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.48892655
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47652508
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.40377143
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40183524
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39987428
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.39500637
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.39201325
27REST_21632747_ChIP-Seq_MESCs_Mouse2.35048384
28* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.34624058
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31874788
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.29566193
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.24420601
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.21512031
33EED_16625203_ChIP-ChIP_MESCs_Mouse2.21103050
34RACK7_27058665_Chip-Seq_MCF-7_Human2.07847231
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07618520
36FOXM1_23109430_ChIP-Seq_U2OS_Human2.06498752
37ZNF263_19887448_ChIP-Seq_K562_Human2.04306726
38IKZF1_21737484_ChIP-ChIP_HCT116_Human2.01945969
39RARG_19884340_ChIP-ChIP_MEFs_Mouse2.00569893
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00383833
41AR_21572438_ChIP-Seq_LNCaP_Human1.99184194
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91962967
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.90939555
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88100406
45* TCF7_22412390_ChIP-Seq_EML_Mouse1.88063422
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.87128108
47DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.85997764
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85645836
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81886395
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79025223
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75642087
52ZNF274_21170338_ChIP-Seq_K562_Hela1.68107343
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.66105145
54P68_20966046_ChIP-Seq_HELA_Human1.65489751
55TAF15_26573619_Chip-Seq_HEK293_Human1.63670348
56MYC_18555785_ChIP-Seq_MESCs_Mouse1.63292705
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61951979
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.61529414
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61284524
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59881910
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55663407
62* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53904021
63* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.52985253
64XRN2_22483619_ChIP-Seq_HELA_Human1.52530040
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51517044
66* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.51414185
67MYC_18358816_ChIP-ChIP_MESCs_Mouse1.47351910
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46962258
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.46192833
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45006803
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44933070
72* SA1_27219007_Chip-Seq_ERYTHROID_Human1.44144464
73WT1_25993318_ChIP-Seq_PODOCYTE_Human1.44071373
74NCOR1_26117541_ChIP-Seq_K562_Human1.43881995
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43414817
76* RING1B_27294783_Chip-Seq_ESCs_Mouse1.42925542
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41072708
78CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.40797293
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40728014
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40678589
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40135794
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39558180
83* MAF_26560356_Chip-Seq_TH2_Human1.38889214
84MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38008573
85* KDM2B_26808549_Chip-Seq_K562_Human1.36605642
86MAF_26560356_Chip-Seq_TH1_Human1.35021442
87* CREB1_26743006_Chip-Seq_LNCaP_Human1.34937881
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34730744
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34725223
90SMC4_20622854_ChIP-Seq_HELA_Human1.34706191
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33979852
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33642798
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33056594
94RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32998559
95RING1B_27294783_Chip-Seq_NPCs_Mouse1.30891113
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.28476375
97ATF3_27146783_Chip-Seq_COLON_Human1.27896450
98ELF1_20517297_ChIP-Seq_JURKAT_Human1.27831043
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.27382857
100ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26937589
101STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26846023
102SMAD4_21799915_ChIP-Seq_A2780_Human1.25817103
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23005994
104SMAD3_21741376_ChIP-Seq_EPCs_Human1.22945116
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22767059
106GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21881486
107SOX2_21211035_ChIP-Seq_LN229_Gbm1.21278683
108TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20861117
109* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19515072
110NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19488758
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19230766
112EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18716345
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18391648
114CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17954262
115UTX_26944678_Chip-Seq_JUKART_Human1.16944599
116MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16481929
117TP53_22127205_ChIP-Seq_IMR90_Human1.15583125
118CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15325321
119ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15112390
120AR_19668381_ChIP-Seq_PC3_Human1.14912933
121THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14867741
122P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14255252
123FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14010570
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13763820
125VDR_24763502_ChIP-Seq_THP-1_Human1.12506553
126* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12478100
127OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11897361
128POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11352988
129OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11103597
130ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10628357
131TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09981322
132AHR_22903824_ChIP-Seq_MCF-7_Human1.09364705
133NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08365421
134CLOCK_20551151_ChIP-Seq_293T_Human1.07935563
135* CTCF_27219007_Chip-Seq_Bcells_Human1.07318046
136ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07070998
137BCOR_27268052_Chip-Seq_Bcells_Human1.06948124
138ARNT_22903824_ChIP-Seq_MCF-7_Human1.06473417
139TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05350388
140* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05197985
141RUNX1_22412390_ChIP-Seq_EML_Mouse1.04675394
142SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04483723
143GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03749623
144NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03463925
145KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03451325
146RARA_24833708_ChIP-Seq_LIVER_Mouse1.03410258
147SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03310606
148BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02836432
149SMAD3_21741376_ChIP-Seq_ESCs_Human1.02769470
150HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02696141
151GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02543626
152P300_19829295_ChIP-Seq_ESCs_Human1.02440256
153STAT3_23295773_ChIP-Seq_U87_Human1.02325533
154DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01923282
155* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01746477
156SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01074142
157BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99574314
158CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99197814
159NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99107442
160RARB_24833708_ChIP-Seq_LIVER_Mouse0.98643443
161PIAS1_25552417_ChIP-Seq_VCAP_Human0.98464637
162BCL6_27268052_Chip-Seq_Bcells_Human0.98354348
163E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97875252
164* KDM2B_26808549_Chip-Seq_JURKAT_Human0.97781124
165FOXP1_21924763_ChIP-Seq_HESCs_Human0.96736514
166RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96205198
167TCF4_23295773_ChIP-Seq_U87_Human0.95751588
168KDM5A_27292631_Chip-Seq_BREAST_Human0.95740217
169STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95389678
170YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92951319
171ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92893770
172ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92530410
173ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92528659
174* KDM2B_26808549_Chip-Seq_DND41_Human0.89996905
175TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89696085
176TET1_21490601_ChIP-Seq_MESCs_Mouse0.89674266
177AR_25329375_ChIP-Seq_VCAP_Human0.88466347
178NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87982827
179SMAD4_21741376_ChIP-Seq_HESCs_Human0.87433841
180TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86501075
181POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86501075
182BCAT_22108803_ChIP-Seq_LS180_Human0.85913666
183SMAD3_21741376_ChIP-Seq_HESCs_Human0.85209739
184TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84863054
185PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84295158
186SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84072325
187EP300_21415370_ChIP-Seq_HL-1_Mouse0.83880639

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.40874604
2MP0003705_abnormal_hypodermis_morpholog4.65126348
3MP0003880_abnormal_central_pattern4.52226666
4MP0003635_abnormal_synaptic_transmissio3.66282919
5MP0005076_abnormal_cell_differentiation3.25517347
6MP0004270_analgesia3.21433888
7MP0005451_abnormal_body_composition3.00094714
8MP0002064_seizures2.96375702
9MP0009745_abnormal_behavioral_response2.90493365
10MP0009046_muscle_twitch2.85551072
11MP0005423_abnormal_somatic_nervous2.71142717
12MP0002063_abnormal_learning/memory/cond2.71039981
13MP0005058_abnormal_lysosome_morphology2.70031993
14MP0001486_abnormal_startle_reflex2.65675659
15MP0002272_abnormal_nervous_system2.65133003
16MP0001849_ear_inflammation2.51960006
17MP0000678_abnormal_parathyroid_gland2.44911931
18MP0002572_abnormal_emotion/affect_behav2.43252771
19MP0001968_abnormal_touch/_nociception2.42284390
20MP0004185_abnormal_adipocyte_glucose2.33754676
21MP0002249_abnormal_larynx_morphology2.31795786
22MP0003111_abnormal_nucleus_morphology2.25232040
23MP0002822_catalepsy2.24715346
24MP0008260_abnormal_autophagy2.18836181
25MP0002734_abnormal_mechanical_nocicepti2.17030488
26MP0010030_abnormal_orbit_morphology2.14339707
27MP0000778_abnormal_nervous_system2.13850175
28MP0003329_amyloid_beta_deposits2.13527277
29MP0008438_abnormal_cutaneous_collagen2.09997155
30MP0003566_abnormal_cell_adhesion2.09670554
31MP0001348_abnormal_lacrimal_gland2.09156361
32MP0002877_abnormal_melanocyte_morpholog2.07258239
33MP0001440_abnormal_grooming_behavior2.06732302
34MP0008569_lethality_at_weaning1.99110802
35MP0002067_abnormal_sensory_capabilities1.98125679
36MP0002736_abnormal_nociception_after1.89442950
37MP0000920_abnormal_myelination1.86697676
38MP0001984_abnormal_olfaction1.86357887
39MP0001730_embryonic_growth_arrest1.82462189
40MP0004885_abnormal_endolymph1.82244455
41MP0009278_abnormal_bone_marrow1.82071736
42MP0003453_abnormal_keratinocyte_physiol1.80639277
43MP0001501_abnormal_sleep_pattern1.79882507
44MP0002184_abnormal_innervation1.79303176
45MP0000955_abnormal_spinal_cord1.74259144
46MP0002733_abnormal_thermal_nociception1.73053270
47MP0002557_abnormal_social/conspecific_i1.71025182
48MP0004742_abnormal_vestibular_system1.69813685
49MP0001970_abnormal_pain_threshold1.67619225
50MP0000858_altered_metastatic_potential1.66985421
51MP0004145_abnormal_muscle_electrophysio1.63039649
52MP0003436_decreased_susceptibility_to1.62434836
53MP0002909_abnormal_adrenal_gland1.62318809
54MP0002882_abnormal_neuron_morphology1.61981422
55MP0003123_paternal_imprinting1.58867488
56MP0005666_abnormal_adipose_tissue1.58160607
57MP0005409_darkened_coat_color1.57825934
58MP0000537_abnormal_urethra_morphology1.57801007
59MP0003693_abnormal_embryo_hatching1.57570697
60MP0000733_abnormal_muscle_development1.56752246
61MP0002735_abnormal_chemical_nociception1.56736876
62MP0005551_abnormal_eye_electrophysiolog1.56358845
63MP0009333_abnormal_splenocyte_physiolog1.54683349
64MP0003077_abnormal_cell_cycle1.54670301
65MP0004924_abnormal_behavior1.54376421
66MP0005386_behavior/neurological_phenoty1.54376421
67MP0001502_abnormal_circadian_rhythm1.52844517
68MP0005501_abnormal_skin_physiology1.50898377
69MP0005375_adipose_tissue_phenotype1.50752222
70MP0003122_maternal_imprinting1.49582066
71MP0004957_abnormal_blastocyst_morpholog1.49088551
72MP0002066_abnormal_motor_capabilities/c1.46903207
73MP0005257_abnormal_intraocular_pressure1.45050381
74MP0000751_myopathy1.44485764
75MP0004811_abnormal_neuron_physiology1.43875293
76MP0004142_abnormal_muscle_tone1.43637976
77MP0003690_abnormal_glial_cell1.42683328
78MP0010094_abnormal_chromosome_stability1.39358037
79MP0010234_abnormal_vibrissa_follicle1.37090686
80MP0000566_synostosis1.36656646
81MP0001905_abnormal_dopamine_level1.35567771
82MP0003634_abnormal_glial_cell1.34287927
83MP0000350_abnormal_cell_proliferation1.34022911
84MP0000490_abnormal_crypts_of1.32117751
85MP0002229_neurodegeneration1.31424290
86MP0003787_abnormal_imprinting1.30965502
87MP0002796_impaired_skin_barrier1.30564009
88MP0004947_skin_inflammation1.30411247
89MP0001529_abnormal_vocalization1.28996148
90MP0003942_abnormal_urinary_system1.28329465
91MP0003633_abnormal_nervous_system1.26991683
92MP0008932_abnormal_embryonic_tissue1.25458601
93MP0001873_stomach_inflammation1.23801229
94MP0006276_abnormal_autonomic_nervous1.22556086
95MP0002396_abnormal_hematopoietic_system1.22422561
96MP0002152_abnormal_brain_morphology1.21805879
97MP0002080_prenatal_lethality1.21551027
98MP0005645_abnormal_hypothalamus_physiol1.21509638
99MP0008007_abnormal_cellular_replicative1.19343927
100MP0006072_abnormal_retinal_apoptosis1.17855944
101MP0002837_dystrophic_cardiac_calcinosis1.15029346
102MP0003091_abnormal_cell_migration1.14641871
103MP0002060_abnormal_skin_morphology1.14451099
104MP0003763_abnormal_thymus_physiology1.13167371
105MP0009840_abnormal_foam_cell1.12728853
106MP0003631_nervous_system_phenotype1.12084540
107MP0003115_abnormal_respiratory_system1.10116220
108MP0009780_abnormal_chondrocyte_physiolo1.09581841
109MP0005499_abnormal_olfactory_system1.08840877
110MP0005394_taste/olfaction_phenotype1.08840877
111MP0009672_abnormal_birth_weight1.08273750
112MP0001672_abnormal_embryogenesis/_devel1.08136575
113MP0005380_embryogenesis_phenotype1.08136575
114MP0003385_abnormal_body_wall1.06856026
115MP0004808_abnormal_hematopoietic_stem1.06323706
116MP0004272_abnormal_basement_membrane1.04357949
117MP0005360_urolithiasis1.04325269
118MP0002085_abnormal_embryonic_tissue1.03414610
119MP0008961_abnormal_basal_metabolism1.03351472
120MP0000569_abnormal_digit_pigmentation1.03236462
121MP0002086_abnormal_extraembryonic_tissu1.03188284
122MP0005621_abnormal_cell_physiology1.02531651
123MP0003984_embryonic_growth_retardation1.02449833
124MP0002752_abnormal_somatic_nervous1.02402937
125MP0001299_abnormal_eye_distance/1.02171359
126MP0002234_abnormal_pharynx_morphology1.01101057
127MP0003632_abnormal_nervous_system1.00871891
128MP0000747_muscle_weakness1.00591818
129MP0001485_abnormal_pinna_reflex0.99756510
130MP0000313_abnormal_cell_death0.99062929
131MP0000631_abnormal_neuroendocrine_gland0.98917951
132MP0003279_aneurysm0.98780797
133MP0003137_abnormal_impulse_conducting0.98284163
134MP0002932_abnormal_joint_morphology0.98116181
135MP0009053_abnormal_anal_canal0.96424556
136MP0001697_abnormal_embryo_size0.96385842
137MP0001915_intracranial_hemorrhage0.96254472
138MP0002088_abnormal_embryonic_growth/wei0.94316021
139MP0000462_abnormal_digestive_system0.93347734
140MP0003879_abnormal_hair_cell0.93107831
141MP0000703_abnormal_thymus_morphology0.93068935
142MP0002090_abnormal_vision0.91967247
143MP0004858_abnormal_nervous_system0.91755826
144MP0004197_abnormal_fetal_growth/weight/0.91560705
145MP0009384_cardiac_valve_regurgitation0.91330133
146MP0001346_abnormal_lacrimal_gland0.91244860
147MP0001216_abnormal_epidermal_layer0.90072571
148MP0010307_abnormal_tumor_latency0.89897890
149MP0002069_abnormal_eating/drinking_beha0.89871794
150MP0005646_abnormal_pituitary_gland0.89173715
151MP0001177_atelectasis0.87472384
152MP0009931_abnormal_skin_appearance0.86917216
153MP0003172_abnormal_lysosome_physiology0.86851851
154MP0004043_abnormal_pH_regulation0.86011827
155MP0008874_decreased_physiological_sensi0.85237850
156MP0000681_abnormal_thyroid_gland0.83603333
157MP0005023_abnormal_wound_healing0.83099183
158MP0005623_abnormal_meninges_morphology0.82273373
159MP0001963_abnormal_hearing_physiology0.82033580
160MP0000604_amyloidosis0.82011386
161MP0004085_abnormal_heartbeat0.81976542
162MP0010630_abnormal_cardiac_muscle0.81946328
163MP0000767_abnormal_smooth_muscle0.80438713
164MP0004233_abnormal_muscle_weight0.80008308
165MP0002970_abnormal_white_adipose0.79751563
166MP0008872_abnormal_physiological_respon0.77816809
167MP0005253_abnormal_eye_physiology0.77780259
168MP0002114_abnormal_axial_skeleton0.77359565
169MP0005384_cellular_phenotype0.77300419
170MP0000428_abnormal_craniofacial_morphol0.76776833
171MP0001943_abnormal_respiration0.76005039
172MP0001340_abnormal_eyelid_morphology0.75904339
173MP0000759_abnormal_skeletal_muscle0.75561381
174MP0002084_abnormal_developmental_patter0.74444521
175MP0002925_abnormal_cardiovascular_devel0.74307107
176MP0003861_abnormal_nervous_system0.73869324
177MP0002116_abnormal_craniofacial_bone0.73267151
178MP0001661_extended_life_span0.72134691
179MP0005195_abnormal_posterior_eye0.71987099
180MP0001958_emphysema0.70977779
181MP0003283_abnormal_digestive_organ0.70289442
182MP0002089_abnormal_postnatal_growth/wei0.68430511
183MP0002092_abnormal_eye_morphology0.68400966
184MP0000003_abnormal_adipose_tissue0.68134716
185MP0000477_abnormal_intestine_morphology0.67738373
186MP0001664_abnormal_digestion0.65124413
187MP0010769_abnormal_survival0.64979434
188MP0005535_abnormal_body_temperature0.63828056
189MP0004036_abnormal_muscle_relaxation0.63817443
190MP0000534_abnormal_ureter_morphology0.63302677
191MP0010770_preweaning_lethality0.63091333

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.34717400
2Supranuclear gaze palsy (HP:0000605)4.88085857
3Focal seizures (HP:0007359)4.68306971
4Visual hallucinations (HP:0002367)4.68251456
5Myokymia (HP:0002411)4.67339723
6Neurofibrillary tangles (HP:0002185)4.25883815
7Cerebral inclusion bodies (HP:0100314)3.93205006
8Epileptic encephalopathy (HP:0200134)3.64852022
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.58108371
10Degeneration of the lateral corticospinal tracts (HP:0002314)3.58108371
11Atonic seizures (HP:0010819)3.50471685
12Ankle clonus (HP:0011448)3.41229614
13Abnormality of the corticospinal tract (HP:0002492)3.38895239
14Spastic gait (HP:0002064)3.37775519
15Absence seizures (HP:0002121)3.32875218
16Ulnar bowing (HP:0003031)3.31724044
17Premature rupture of membranes (HP:0001788)3.29244172
18Broad face (HP:0000283)3.29153794
19Protrusio acetabuli (HP:0003179)3.26198143
20Dysmetria (HP:0001310)3.22182530
21Action tremor (HP:0002345)3.10457859
22Biconcave vertebral bodies (HP:0004586)3.09899507
23Broad-based gait (HP:0002136)3.07544875
24Dialeptic seizures (HP:0011146)3.02276059
25Progressive cerebellar ataxia (HP:0002073)3.01638541
26Disproportionate tall stature (HP:0001519)2.98919000
27Obstructive sleep apnea (HP:0002870)2.98562242
28Long palpebral fissure (HP:0000637)2.97880326
29Febrile seizures (HP:0002373)2.97674412
30Cerebral aneurysm (HP:0004944)2.81012197
31Cervical subluxation (HP:0003308)2.79274302
32Insidious onset (HP:0003587)2.75109988
33Termporal pattern (HP:0011008)2.75109988
34Intention tremor (HP:0002080)2.73345802
35Dysdiadochokinesis (HP:0002075)2.72990932
36Gaze-evoked nystagmus (HP:0000640)2.70643290
37Upper limb amyotrophy (HP:0009129)2.69302984
38Distal upper limb amyotrophy (HP:0007149)2.69302984
39Generalized tonic-clonic seizures (HP:0002069)2.67099714
40Broad distal phalanx of finger (HP:0009836)2.65294469
41Impaired vibration sensation in the lower limbs (HP:0002166)2.64055421
42Achilles tendon contracture (HP:0001771)2.63527501
43Scanning speech (HP:0002168)2.60904520
44Insomnia (HP:0100785)2.59965952
45Truncal ataxia (HP:0002078)2.59797435
46Stridor (HP:0010307)2.58168341
47Depression (HP:0000716)2.57552342
48Urinary urgency (HP:0000012)2.54438397
49Hemiplegia (HP:0002301)2.53777666
50J-shaped sella turcica (HP:0002680)2.48521379
51Peripheral hypomyelination (HP:0007182)2.48135066
52Fragile skin (HP:0001030)2.46401252
53Distal lower limb amyotrophy (HP:0008944)2.45718802
54Anxiety (HP:0000739)2.43349780
55Postural instability (HP:0002172)2.42302259
56Abnormal eating behavior (HP:0100738)2.40720881
57Truncus arteriosus (HP:0001660)2.40310713
58Urinary bladder sphincter dysfunction (HP:0002839)2.38407428
59Reticulocytosis (HP:0001923)2.37334405
60Neoplasm of the heart (HP:0100544)2.34536916
61Excessive salivation (HP:0003781)2.33836202
62Drooling (HP:0002307)2.33836202
63Abnormality of the Achilles tendon (HP:0005109)2.33682419
64Diplopia (HP:0000651)2.33414506
65Abnormality of binocular vision (HP:0011514)2.33414506
66Hemiparesis (HP:0001269)2.33135118
67Increased connective tissue (HP:0009025)2.31747990
68Anteriorly placed anus (HP:0001545)2.30794043
69Lower limb muscle weakness (HP:0007340)2.30686066
70Shallow orbits (HP:0000586)2.30131755
71Neuronal loss in central nervous system (HP:0002529)2.27637443
72Mitral regurgitation (HP:0001653)2.25339019
73Abnormal gallbladder physiology (HP:0012438)2.25273091
74Cholecystitis (HP:0001082)2.25273091
75Turricephaly (HP:0000262)2.23584088
76Amblyopia (HP:0000646)2.21916948
77Premature skin wrinkling (HP:0100678)2.21899281
78Deep palmar crease (HP:0006191)2.21784103
79Megalencephaly (HP:0001355)2.20917573
80Thin bony cortex (HP:0002753)2.20809912
81Vertebral compression fractures (HP:0002953)2.20432811
82Limb dystonia (HP:0002451)2.20127579
83Abnormal social behavior (HP:0012433)2.17728425
84Impaired social interactions (HP:0000735)2.17728425
85Flat acetabular roof (HP:0003180)2.17189823
86Ankyloglossia (HP:0010296)2.14094461
87Rapidly progressive (HP:0003678)2.12006129
88Retinal dysplasia (HP:0007973)2.11883103
89Atelectasis (HP:0100750)2.10328421
90Hyperthyroidism (HP:0000836)2.09559554
91Overriding aorta (HP:0002623)2.09539790
92Patellar dislocation (HP:0002999)2.09329143
93Metaphyseal cupping (HP:0003021)2.08980355
94Poor eye contact (HP:0000817)2.08198387
95Clonus (HP:0002169)2.07816960
96Ventricular fibrillation (HP:0001663)2.05668865
97Hypertensive crisis (HP:0100735)2.05328109
98Psychosis (HP:0000709)2.05064478
99Myopathic facies (HP:0002058)2.04102622
100Abnormality of the thoracic spine (HP:0100711)2.03090228
101Hypoventilation (HP:0002791)2.02377852
102Poor speech (HP:0002465)2.02277657
103Onion bulb formation (HP:0003383)2.01638670
104Prolonged QT interval (HP:0001657)2.00685587
105Split foot (HP:0001839)2.00489514
106Narrow nasal bridge (HP:0000446)2.00010700
107Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.99806771
108Type II lissencephaly (HP:0007260)1.98449538
109Renal duplication (HP:0000075)1.98247711
110EEG with generalized epileptiform discharges (HP:0011198)1.98058162
111Abnormality of oral frenula (HP:0000190)1.97782617
112Hypoplasia of the brainstem (HP:0002365)1.97314406
113Aplasia/Hypoplasia of the brainstem (HP:0007362)1.97314406
114Hand muscle atrophy (HP:0009130)1.96337420
115Blue sclerae (HP:0000592)1.95960912
116Dislocated radial head (HP:0003083)1.95560475
117Epileptiform EEG discharges (HP:0011182)1.95206098
118Thin ribs (HP:0000883)1.94296572
119Absent speech (HP:0001344)1.94286829
120Hyperventilation (HP:0002883)1.93823946
121Stereotypic behavior (HP:0000733)1.93635971
122Syringomyelia (HP:0003396)1.92871148
123Spinal cord lesions (HP:0100561)1.92871148
124Generalized hypotonia (HP:0001290)1.92320420
125Selective tooth agenesis (HP:0001592)1.90990523
126Hyperacusis (HP:0010780)1.90653323
127Elbow flexion contracture (HP:0002987)1.89182343
128Trismus (HP:0000211)1.88667085
129Genu recurvatum (HP:0002816)1.88565065
130Impaired smooth pursuit (HP:0007772)1.88552006
131Abnormality of the calcaneus (HP:0008364)1.87980898
132Torticollis (HP:0000473)1.87442692
133Bradykinesia (HP:0002067)1.87426743
134Pointed chin (HP:0000307)1.87133202
135Hemorrhage of the eye (HP:0011885)1.87115656
136Genetic anticipation (HP:0003743)1.87048211
137Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86918826
138Bowing of the arm (HP:0006488)1.86079363
139Bowed forearm bones (HP:0003956)1.86079363
140Abnormality of reticulocytes (HP:0004312)1.85817137
141Agitation (HP:0000713)1.84757128
142Lower limb asymmetry (HP:0100559)1.83602702
143Deviation of the thumb (HP:0009603)1.83462890
144Buphthalmos (HP:0000557)1.83460189
145Abnormality of the radial head (HP:0003995)1.83115147
146Bowel incontinence (HP:0002607)1.82224722
147Abnormality of the distal phalanges of the toes (HP:0010182)1.82164237
148Short nail (HP:0001799)1.81795099
149Squamous cell carcinoma (HP:0002860)1.81627103
150Hypsarrhythmia (HP:0002521)1.81463048
151Bladder diverticulum (HP:0000015)1.81411413
152Fetal akinesia sequence (HP:0001989)1.81386991
153Abnormality of saccadic eye movements (HP:0000570)1.81308276
154Bronchomalacia (HP:0002780)1.80954811
155Hypoplastic nipples (HP:0002557)1.80750062
156Increased nuchal translucency (HP:0010880)1.80607223
157Postural tremor (HP:0002174)1.80171199
158Progressive inability to walk (HP:0002505)1.79087302
159Abnormality of the tricuspid valve (HP:0001702)1.77843054
160Spinal rigidity (HP:0003306)1.77641025
161Polyphagia (HP:0002591)1.77514469
162Widely spaced teeth (HP:0000687)1.77481532
163Proximal placement of thumb (HP:0009623)1.77200132
164Poikiloderma (HP:0001029)1.77040234
165Morphological abnormality of the pyramidal tract (HP:0002062)1.77033027
166Aplasia of the phalanges of the hand (HP:0009802)1.76922220
167Aplasia involving bones of the extremities (HP:0009825)1.76922220
168Aplasia involving bones of the upper limbs (HP:0009823)1.76922220
169Seborrheic dermatitis (HP:0001051)1.76823050
170Abnormality of the parathyroid morphology (HP:0011766)1.76804096
171Heterotopia (HP:0002282)1.75659716
172Progressive muscle weakness (HP:0003323)1.74684554
173Easy fatigability (HP:0003388)1.74245417
174Deep venous thrombosis (HP:0002625)1.73283201
175Atrophic scars (HP:0001075)1.72222229
176Dysmetric saccades (HP:0000641)1.70099716
177Hypoparathyroidism (HP:0000829)1.68750841
178Mildly elevated creatine phosphokinase (HP:0008180)1.68372574
179Abnormal large intestine physiology (HP:0012700)1.68079420
180Advanced eruption of teeth (HP:0006288)1.67219186
181Progressive external ophthalmoplegia (HP:0000590)1.67198561
182Abnormality of the distal phalanx of the thumb (HP:0009617)1.66910528
183Entropion (HP:0000621)1.66509998
184Difficulty climbing stairs (HP:0003551)1.66249432
185Long eyelashes (HP:0000527)1.66018482
186Ragged-red muscle fibers (HP:0003200)1.65721977
187Abnormality of the aortic arch (HP:0012303)1.65201914
188Sparse lateral eyebrow (HP:0005338)1.64072427
189Nuclear cataract (HP:0100018)1.63612516
190Natal tooth (HP:0000695)1.61328062
191Centrally nucleated skeletal muscle fibers (HP:0003687)1.61277815
192Self-mutilation (HP:0000742)1.60077429
193Elfin facies (HP:0004428)1.59368670
194Abnormality of the umbilical cord (HP:0010881)1.59297825
195Asymmetry of the thorax (HP:0001555)1.58920817
196Arnold-Chiari malformation (HP:0002308)1.58599578

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.65786075
2SIK13.62345025
3NTRK33.09111666
4EPHA42.99203404
5TNIK2.82743738
6IRAK32.77422115
7PNCK2.75100224
8CDK122.45922349
9MARK12.38273893
10NME22.29441570
11PAK62.29115952
12MAP3K42.26663741
13ERN12.26202822
14CAMK1G2.22470220
15STK392.13455275
16UHMK12.10218080
17SIK22.10076021
18DAPK22.05094984
19FGFR42.02581231
20PHKG11.97315744
21PHKG21.97315744
22EPHA21.91087256
23MAP3K91.90924027
24NTRK21.90304093
25FES1.82163681
26MINK11.80377885
27MAP2K31.66883719
28MST1R1.65244542
29OXSR11.64533947
30TYRO31.61615075
31RIPK41.59119998
32MAPK131.58410760
33NTRK11.47394980
34LMTK21.45763086
35WNK41.45079885
36CDK191.44772786
37PRKD31.39306108
38CDK51.39092586
39MTOR1.38518898
40WNK11.38340993
41FGFR21.37282130
42KSR21.34529995
43MAP2K41.30986052
44MAP2K71.30323162
45EPHB11.30080183
46CAMKK21.29204923
47CAMKK11.29125285
48MAPKAPK51.29096910
49PAK31.22291948
50MAP3K21.22275874
51ICK1.21193964
52PTK61.18277247
53RET1.18261674
54STK381.12710871
55MARK21.12401538
56PIM21.08177327
57PTK21.05445534
58BMX1.04157667
59CDK71.00039852
60SGK2230.99725254
61SGK4940.99725254
62SIK30.99516237
63TAOK20.98118387
64PRPF4B0.97285264
65PKN10.97231542
66CAMK2B0.96408377
67PAK40.96030895
68CAMK1D0.95272640
69PTK2B0.94963990
70CAMK10.94613217
71CSNK1G20.93428211
72CDK40.92480091
73CDK80.91578163
74MAP3K110.91057520
75LATS20.90679419
76PRKCH0.88911897
77GRK50.87903328
78CDC42BPA0.87348511
79BRAF0.87276548
80NEK20.86788100
81IRAK20.86384330
82MAP3K80.85551021
83RPS6KA20.85515341
84STK110.85294352
85DYRK1A0.84435107
86CSNK1A1L0.83713216
87CAMK2A0.83559126
88ARAF0.82516356
89HIPK20.80958630
90CSNK1G30.80600927
91MET0.80458329
92FYN0.76866800
93MAP4K10.76526361
94CDK150.76417605
95KSR10.76276586
96PDPK10.76073639
97PDGFRB0.75571130
98PDGFRA0.74490358
99RPS6KC10.74089571
100RPS6KL10.74089571
101CDK11A0.73989499
102TAOK10.71494499
103FGR0.70507388
104PRKD10.69604653
105CDK180.69189309
106CDK140.68927592
107ROCK20.68392331
108TRIB30.68296750
109CAMK2D0.67952715
110PRKCG0.67759920
111BRSK10.67400426
112MAP3K10.67277064
113MAP3K70.66674735
114RIPK10.65394920
115MAP3K140.65332409
116TBK10.63538009
117MAPK110.63184369
118PDK10.63082580
119MAP3K130.60957568
120MAP2K20.60714718
121PRKD20.60345246
122MAP3K100.59143054
123IRAK40.58146390
124PKN20.58034955
125CDK90.56700640
126MAP3K30.56666457
127TESK20.54872298
128SGK10.54301482
129CHEK10.53880169
130TNK20.53835696
131DYRK1B0.52147870
132DAPK10.51340896
133CSNK1G10.50890219
134RPS6KA60.50843096
135CLK10.50325081
136LRRK20.50141492
137TESK10.49597373
138RPS6KB20.48168314
139DDR20.47868388
140CHEK20.47766240
141RPS6KA30.47587093
142MAP3K60.47460811
143PRKCQ0.47231980
144EEF2K0.47092759
145ERBB20.45917424
146AURKA0.45190868
147CAMK2G0.45088169
148MAPK100.45070104
149MAPK120.44771742
150CASK0.44278018
151BUB10.42789171
152ZAP700.42523265
153ALK0.42494011
154ILK0.42022493
155NME10.40268784
156GRK60.39934927
157CDK20.39624872
158TTN0.39469276
159TTK0.39200423
160PAK20.37590102
161MAP2K60.37538353
162CDK60.36023349
163TYK20.35510649
164BRD40.35120854
165AKT20.33723864

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.13343190
2Glutamatergic synapse_Homo sapiens_hsa047242.62269548
3Other glycan degradation_Homo sapiens_hsa005112.57445770
4Synaptic vesicle cycle_Homo sapiens_hsa047212.55543472
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.50120995
6GABAergic synapse_Homo sapiens_hsa047272.43469892
7Circadian entrainment_Homo sapiens_hsa047132.40138167
8Morphine addiction_Homo sapiens_hsa050322.39344760
9Olfactory transduction_Homo sapiens_hsa047402.32848367
10Notch signaling pathway_Homo sapiens_hsa043302.31498934
11Chronic myeloid leukemia_Homo sapiens_hsa052202.31172599
12Long-term potentiation_Homo sapiens_hsa047202.26366667
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.11567022
14Bladder cancer_Homo sapiens_hsa052192.06632617
15Amphetamine addiction_Homo sapiens_hsa050312.03563626
16Salivary secretion_Homo sapiens_hsa049702.03167825
17Dopaminergic synapse_Homo sapiens_hsa047281.95919538
18Acute myeloid leukemia_Homo sapiens_hsa052211.91878269
19Central carbon metabolism in cancer_Homo sapiens_hsa052301.91726566
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.90715829
21Gastric acid secretion_Homo sapiens_hsa049711.87239537
22Cholinergic synapse_Homo sapiens_hsa047251.86449106
23Renin secretion_Homo sapiens_hsa049241.79884209
24DNA replication_Homo sapiens_hsa030301.75716273
25Insulin secretion_Homo sapiens_hsa049111.75187959
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.73388186
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71517232
28Taste transduction_Homo sapiens_hsa047421.71096619
29Sulfur relay system_Homo sapiens_hsa041221.69572996
30Long-term depression_Homo sapiens_hsa047301.67096884
31Cocaine addiction_Homo sapiens_hsa050301.65787040
32Biosynthesis of amino acids_Homo sapiens_hsa012301.63921623
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63010324
34Axon guidance_Homo sapiens_hsa043601.60165787
35Pentose phosphate pathway_Homo sapiens_hsa000301.59899511
36Oxytocin signaling pathway_Homo sapiens_hsa049211.57752341
37Serotonergic synapse_Homo sapiens_hsa047261.56758164
38Fructose and mannose metabolism_Homo sapiens_hsa000511.52190183
39Pancreatic cancer_Homo sapiens_hsa052121.43350032
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42150740
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41265350
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.39471232
43Calcium signaling pathway_Homo sapiens_hsa040201.38456173
44Type II diabetes mellitus_Homo sapiens_hsa049301.37520138
45Thyroid cancer_Homo sapiens_hsa052161.36696991
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.33240699
47GnRH signaling pathway_Homo sapiens_hsa049121.32931351
48Base excision repair_Homo sapiens_hsa034101.31142928
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29805922
50Endometrial cancer_Homo sapiens_hsa052131.26727918
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26691564
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25669184
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25283601
54Gap junction_Homo sapiens_hsa045401.24305784
55Cell cycle_Homo sapiens_hsa041101.22710766
56cAMP signaling pathway_Homo sapiens_hsa040241.22549302
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22326783
58Galactose metabolism_Homo sapiens_hsa000521.22142285
59MicroRNAs in cancer_Homo sapiens_hsa052061.20954381
60Small cell lung cancer_Homo sapiens_hsa052221.18878727
61Pancreatic secretion_Homo sapiens_hsa049721.17347906
62mRNA surveillance pathway_Homo sapiens_hsa030151.16390370
63cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16264621
64Prion diseases_Homo sapiens_hsa050201.15481671
65Estrogen signaling pathway_Homo sapiens_hsa049151.15035693
66Cardiac muscle contraction_Homo sapiens_hsa042601.11877754
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.11686678
68Phospholipase D signaling pathway_Homo sapiens_hsa040721.11520770
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10936438
70Collecting duct acid secretion_Homo sapiens_hsa049661.10753829
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09506924
72Vascular smooth muscle contraction_Homo sapiens_hsa042701.07062574
73Lysine degradation_Homo sapiens_hsa003101.06801742
74Spliceosome_Homo sapiens_hsa030401.06609052
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05859940
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05018112
77Apoptosis_Homo sapiens_hsa042100.99702938
78Dorso-ventral axis formation_Homo sapiens_hsa043200.98709040
79Melanogenesis_Homo sapiens_hsa049160.97524917
80Hepatitis B_Homo sapiens_hsa051610.97504716
81Proteoglycans in cancer_Homo sapiens_hsa052050.96928768
82Choline metabolism in cancer_Homo sapiens_hsa052310.95629560
83Glioma_Homo sapiens_hsa052140.94879111
84Viral carcinogenesis_Homo sapiens_hsa052030.92896879
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92873674
86Dilated cardiomyopathy_Homo sapiens_hsa054140.92832322
87ErbB signaling pathway_Homo sapiens_hsa040120.92545325
88AMPK signaling pathway_Homo sapiens_hsa041520.92082237
89Shigellosis_Homo sapiens_hsa051310.92041908
90Prostate cancer_Homo sapiens_hsa052150.91544561
91Colorectal cancer_Homo sapiens_hsa052100.90743460
92Renal cell carcinoma_Homo sapiens_hsa052110.90644426
93Phototransduction_Homo sapiens_hsa047440.88884851
94Focal adhesion_Homo sapiens_hsa045100.88375371
95HTLV-I infection_Homo sapiens_hsa051660.87446616
96N-Glycan biosynthesis_Homo sapiens_hsa005100.85851372
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83624976
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82783649
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81268582
100VEGF signaling pathway_Homo sapiens_hsa043700.80855821
101HIF-1 signaling pathway_Homo sapiens_hsa040660.78598628
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77198931
103Hepatitis C_Homo sapiens_hsa051600.75677064
104Thyroid hormone synthesis_Homo sapiens_hsa049180.75590804
105Prolactin signaling pathway_Homo sapiens_hsa049170.75106595
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74715345
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74028478
108MAPK signaling pathway_Homo sapiens_hsa040100.72500920
109Basal cell carcinoma_Homo sapiens_hsa052170.72385579
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.72341189
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72316215
112TNF signaling pathway_Homo sapiens_hsa046680.72068124
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69270963
114RNA transport_Homo sapiens_hsa030130.67310969
115Alzheimers disease_Homo sapiens_hsa050100.66456248
116Carbon metabolism_Homo sapiens_hsa012000.65844682
117Epstein-Barr virus infection_Homo sapiens_hsa051690.64697837
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.63840175
119ECM-receptor interaction_Homo sapiens_hsa045120.61926387
120Inositol phosphate metabolism_Homo sapiens_hsa005620.61651079
121Vibrio cholerae infection_Homo sapiens_hsa051100.61289058
122Osteoclast differentiation_Homo sapiens_hsa043800.61121764
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59965780
124Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59711771
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59656556
126Adherens junction_Homo sapiens_hsa045200.59440183
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59215256
128Endocytosis_Homo sapiens_hsa041440.59082960
129Nitrogen metabolism_Homo sapiens_hsa009100.58929548
130Glucagon signaling pathway_Homo sapiens_hsa049220.58898975
131Pathways in cancer_Homo sapiens_hsa052000.58406135
132Insulin resistance_Homo sapiens_hsa049310.57737587
133Ether lipid metabolism_Homo sapiens_hsa005650.57097599
134Non-small cell lung cancer_Homo sapiens_hsa052230.56459561
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56319121
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54927845
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54863268
138Nucleotide excision repair_Homo sapiens_hsa034200.54834055
139Ras signaling pathway_Homo sapiens_hsa040140.54681121
140Influenza A_Homo sapiens_hsa051640.54403404
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53668950
142Rap1 signaling pathway_Homo sapiens_hsa040150.53184162
143Platelet activation_Homo sapiens_hsa046110.53078000
144Lysosome_Homo sapiens_hsa041420.52722938
145Alcoholism_Homo sapiens_hsa050340.52625135
146Herpes simplex infection_Homo sapiens_hsa051680.52037871
147p53 signaling pathway_Homo sapiens_hsa041150.51218986
148Leukocyte transendothelial migration_Homo sapiens_hsa046700.51081107
149Salmonella infection_Homo sapiens_hsa051320.50231513
150Neurotrophin signaling pathway_Homo sapiens_hsa047220.50228108
151Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50123547
152Bile secretion_Homo sapiens_hsa049760.49558250
153Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49398103
154NF-kappa B signaling pathway_Homo sapiens_hsa040640.49345889
155Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49020958
156Hippo signaling pathway_Homo sapiens_hsa043900.48767408
157Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47601140
158Wnt signaling pathway_Homo sapiens_hsa043100.46738766
159Insulin signaling pathway_Homo sapiens_hsa049100.46622240
160mTOR signaling pathway_Homo sapiens_hsa041500.45149656
161Circadian rhythm_Homo sapiens_hsa047100.43612414
162Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41800446
163Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41676050
164T cell receptor signaling pathway_Homo sapiens_hsa046600.41624156
165Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40588520
166Glycerophospholipid metabolism_Homo sapiens_hsa005640.40130279
167B cell receptor signaling pathway_Homo sapiens_hsa046620.39436408
168Oocyte meiosis_Homo sapiens_hsa041140.37450426
169Fatty acid elongation_Homo sapiens_hsa000620.37396308
170Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37046467
171Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36930286
172Fatty acid biosynthesis_Homo sapiens_hsa000610.36813748
173Parkinsons disease_Homo sapiens_hsa050120.36058438

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