KLHL18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal cone cell development (GO:0046549)9.00990406
2photoreceptor cell development (GO:0042461)7.49816177
3eye photoreceptor cell development (GO:0042462)7.12295402
4photoreceptor cell maintenance (GO:0045494)6.91159232
5detection of light stimulus involved in sensory perception (GO:0050962)6.53303715
6detection of light stimulus involved in visual perception (GO:0050908)6.53303715
7phototransduction (GO:0007602)6.39785715
8phototransduction, visible light (GO:0007603)6.18466880
9positive regulation of guanylate cyclase activity (GO:0031284)6.16029582
10detection of light stimulus (GO:0009583)6.10571627
11detection of visible light (GO:0009584)6.00409499
12retinal rod cell development (GO:0046548)5.99216865
13regulation of guanylate cyclase activity (GO:0031282)5.49013622
14GMP metabolic process (GO:0046037)5.31643831
15visual perception (GO:0007601)5.22682838
16protein-chromophore linkage (GO:0018298)5.16217812
17sensory perception of light stimulus (GO:0050953)5.15212025
18mitotic chromosome condensation (GO:0007076)4.93840076
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.60898572
20nuclear pore complex assembly (GO:0051292)4.44590616
21eye photoreceptor cell differentiation (GO:0001754)4.41707877
22photoreceptor cell differentiation (GO:0046530)4.41707877
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.37151389
24positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.33788795
25regulation of short-term neuronal synaptic plasticity (GO:0048172)4.31187071
26synaptic vesicle maturation (GO:0016188)4.24809389
27cellular response to light stimulus (GO:0071482)4.23170176
28detection of external stimulus (GO:0009581)4.22100228
29regulation of clathrin-mediated endocytosis (GO:2000369)4.19890081
30detection of abiotic stimulus (GO:0009582)4.11308482
31protein localization to chromosome, centromeric region (GO:0071459)4.10369654
32retina development in camera-type eye (GO:0060041)4.01141140
33mitotic metaphase plate congression (GO:0007080)3.93753212
34regulation of cGMP metabolic process (GO:0030823)3.89012876
35nuclear pore organization (GO:0006999)3.84957076
36protein localization to synapse (GO:0035418)3.84631065
37adaptation of signaling pathway (GO:0023058)3.84595589
38regulation of histone H3-K9 methylation (GO:0051570)3.83404728
39sodium ion export (GO:0071436)3.77193609
40negative regulation of histone methylation (GO:0031061)3.71771306
41positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.68956327
42transcription from mitochondrial promoter (GO:0006390)3.64810198
43positive regulation of cGMP biosynthetic process (GO:0030828)3.58540474
44regulation of DNA methylation (GO:0044030)3.56000622
45pore complex assembly (GO:0046931)3.51320856
46synaptic vesicle docking involved in exocytosis (GO:0016081)3.49277999
47locomotory exploration behavior (GO:0035641)3.47387842
48piRNA metabolic process (GO:0034587)3.41993635
49regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.40529747
50establishment of chromosome localization (GO:0051303)3.39185524
51regulation of RNA export from nucleus (GO:0046831)3.37847073
52DNA strand elongation (GO:0022616)3.37550542
53DNA strand elongation involved in DNA replication (GO:0006271)3.35414748
54regulation of cGMP biosynthetic process (GO:0030826)3.31891226
55N-terminal protein amino acid acetylation (GO:0006474)3.25366086
56protein localization to kinetochore (GO:0034501)3.25064979
57regulation of voltage-gated calcium channel activity (GO:1901385)3.23796894
58synaptic vesicle exocytosis (GO:0016079)3.23389874
59telomere maintenance via semi-conservative replication (GO:0032201)3.21892555
60regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.21537392
61positive regulation of chromosome segregation (GO:0051984)3.20090467
62metaphase plate congression (GO:0051310)3.19427041
63mitotic nuclear envelope disassembly (GO:0007077)3.18114556
64regulation of double-strand break repair via homologous recombination (GO:0010569)3.12914801
65membrane disassembly (GO:0030397)3.12851720
66nuclear envelope disassembly (GO:0051081)3.12851720
67response to histamine (GO:0034776)3.11001579
68positive regulation of cGMP metabolic process (GO:0030825)3.07698624
69glutamate secretion (GO:0014047)3.05291196
70synaptic vesicle endocytosis (GO:0048488)3.05263651
71cellular potassium ion homeostasis (GO:0030007)3.05074091
72activation of protein kinase A activity (GO:0034199)3.04730177
73histone H3-K4 methylation (GO:0051568)3.02832493
74regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.01705888
75regulation of ARF protein signal transduction (GO:0032012)3.01494982
76protein K6-linked ubiquitination (GO:0085020)3.01451560
77dopamine receptor signaling pathway (GO:0007212)3.00394489
78receptor guanylyl cyclase signaling pathway (GO:0007168)2.99336327
79regulation of chromatin binding (GO:0035561)2.98891137
80mitotic sister chromatid segregation (GO:0000070)2.98378526
81layer formation in cerebral cortex (GO:0021819)2.95412423
82mitochondrial RNA metabolic process (GO:0000959)2.93957902
83histone H3-K4 trimethylation (GO:0080182)2.91954557
84telomere maintenance via recombination (GO:0000722)2.90199446
85positive regulation of mitotic sister chromatid separation (GO:1901970)2.89614012
86positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.89614012
87positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.89614012
88negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.89429565
89regulation of meiosis I (GO:0060631)2.89422620
90meiotic cell cycle (GO:0051321)2.87981027
91positive regulation of histone H3-K4 methylation (GO:0051571)2.85881962
92regulation of synaptic vesicle exocytosis (GO:2000300)2.84870935
93regulation of histone methylation (GO:0031060)2.84235832
94protein localization to chromosome (GO:0034502)2.82197685
95DNA unwinding involved in DNA replication (GO:0006268)2.81881318
96positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.81839551
97DNA replication initiation (GO:0006270)2.81712605
98histone demethylation (GO:0016577)2.81684096
99ribosome assembly (GO:0042255)2.81193023
100attachment of spindle microtubules to kinetochore (GO:0008608)2.80447793
101positive regulation of neurotransmitter transport (GO:0051590)2.75780229
102histone lysine demethylation (GO:0070076)2.74501492
103positive regulation of membrane potential (GO:0045838)2.72538720
104negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.71951171
105negative regulation of cell killing (GO:0031342)2.71951171
106regulation of histone H3-K4 methylation (GO:0051569)2.71755507
107sister chromatid segregation (GO:0000819)2.70494115
108nucleotide-excision repair, DNA gap filling (GO:0006297)2.67059835
109DNA topological change (GO:0006265)2.66759726
110negative regulation of receptor-mediated endocytosis (GO:0048261)2.66659944
111DNA replication checkpoint (GO:0000076)2.66383639
112erythrocyte development (GO:0048821)2.66099773
113positive regulation of histone methylation (GO:0031062)2.65073124
114positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.64878319
115mitotic recombination (GO:0006312)2.63956236
116regulation of synaptic vesicle transport (GO:1902803)2.61654882
117DNA methylation involved in gamete generation (GO:0043046)2.61233564
118chemosensory behavior (GO:0007635)2.60459555
119regulation of spindle organization (GO:0090224)2.60199404
120dosage compensation (GO:0007549)2.59733880
121nuclear envelope organization (GO:0006998)2.59582465
122phospholipid translocation (GO:0045332)2.59062869
123lipid translocation (GO:0034204)2.59062869
124protein dealkylation (GO:0008214)2.58586387
125protein demethylation (GO:0006482)2.58586387
126G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.58230407
127chromosome segregation (GO:0007059)2.57970095
128membrane hyperpolarization (GO:0060081)2.57402890
129positive regulation of sodium ion transmembrane transport (GO:1902307)2.56879524
130cell morphogenesis involved in neuron differentiation (GO:0048667)2.56550422
131protoporphyrinogen IX metabolic process (GO:0046501)2.56338667
132regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.56205237
133regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.56205237
134regulation of nucleobase-containing compound transport (GO:0032239)2.55855923
135regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.54592863
136positive regulation of humoral immune response (GO:0002922)2.53555889
137ribosome biogenesis (GO:0042254)2.52689582
138positive regulation of vesicle fusion (GO:0031340)2.52636709
139spliceosomal tri-snRNP complex assembly (GO:0000244)2.52509519
140behavioral defense response (GO:0002209)2.51380807
141behavioral fear response (GO:0001662)2.51380807
142kinetochore organization (GO:0051383)2.47874859
143formation of translation preinitiation complex (GO:0001731)2.47749433
144somatic diversification of immune receptors via somatic mutation (GO:0002566)2.47480260
145somatic hypermutation of immunoglobulin genes (GO:0016446)2.47480260
146DNA synthesis involved in DNA repair (GO:0000731)2.47393392
147cellular response to radiation (GO:0071478)2.46601436
148protoporphyrinogen IX biosynthetic process (GO:0006782)2.46527938
149sensory perception (GO:0007600)2.46177879
150ncRNA 3-end processing (GO:0043628)2.45930021
151histone H3-K36 demethylation (GO:0070544)2.45760906
152cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.44637983
153regulation of chromosome segregation (GO:0051983)2.44629793
154gene silencing by RNA (GO:0031047)2.44548781
155regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.43214017
156regulation of mitotic metaphase/anaphase transition (GO:0030071)2.43214017
157DNA alkylation (GO:0006305)2.42907425
158DNA methylation (GO:0006306)2.42907425
159nonmotile primary cilium assembly (GO:0035058)2.42518385
160transcription-coupled nucleotide-excision repair (GO:0006283)2.42123002
161positive regulation of gamma-delta T cell activation (GO:0046645)2.40499011
162cortical actin cytoskeleton organization (GO:0030866)2.40225128
163mitotic sister chromatid cohesion (GO:0007064)2.40221078
164CENP-A containing nucleosome assembly (GO:0034080)2.39695816
165peptidyl-lysine trimethylation (GO:0018023)2.39487196
166vocalization behavior (GO:0071625)2.39200253
167neuron development (GO:0048666)2.38135878
168negative regulation of histone modification (GO:0031057)2.37983769
169regulation of DNA endoreduplication (GO:0032875)2.37793082
170negative regulation of chromosome segregation (GO:0051985)2.36183242
171response to light stimulus (GO:0009416)2.35357471
172histone H3-K9 demethylation (GO:0033169)2.35320232
173response to peptidoglycan (GO:0032494)2.35192062
174positive regulation by organism of defense response of other organism involved in symbiotic interact2.35063569
175modulation by symbiont of host immune response (GO:0052553)2.35063569
176positive regulation by symbiont of host defense response (GO:0052509)2.35063569
177modulation by symbiont of host defense response (GO:0052031)2.35063569
178modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.35063569
179modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.35063569
180cytoplasmic mRNA processing body assembly (GO:0033962)2.34745206
181potassium ion import (GO:0010107)2.33973327
182regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.33896904
183cellular protein complex localization (GO:0034629)2.33124980
184snRNA metabolic process (GO:0016073)2.33045222
185regulation of glutamate receptor signaling pathway (GO:1900449)2.32964713
186fear response (GO:0042596)2.31096581
187long-term memory (GO:0007616)2.30930759
188CDP-diacylglycerol biosynthetic process (GO:0016024)2.30284638
189regulation of neurotransmitter secretion (GO:0046928)2.29376636
190regulation of NFAT protein import into nucleus (GO:0051532)2.28826141
191peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.27749468
192establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.27506013
193mitochondrion transport along microtubule (GO:0047497)2.27506013
194neurotransmitter secretion (GO:0007269)2.26657379
195cell communication by electrical coupling (GO:0010644)2.25836843
196response to pheromone (GO:0019236)2.25585372
197lipoprotein transport (GO:0042953)2.23901286
198potassium ion homeostasis (GO:0055075)2.21645737
199regulation of rhodopsin mediated signaling pathway (GO:0022400)10.6700397
200rhodopsin mediated signaling pathway (GO:0016056)10.4220124

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.56396285
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.42861730
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.22669603
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.15554336
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.08622030
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.02570212
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.98027798
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.93953173
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.93912121
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.88755641
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.81245929
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.78907551
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.67134788
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55914927
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.38328216
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.36304435
17* ETS1_20019798_ChIP-Seq_JURKAT_Human2.32000099
18POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.30196996
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.27504582
20DROSHA_22980978_ChIP-Seq_HELA_Human2.26591025
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21942185
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.19320860
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.17059169
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.13579251
25* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13564573
26KDM2B_26808549_Chip-Seq_SUP-B15_Human2.12917106
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.10232605
28STAT6_21828071_ChIP-Seq_BEAS2B_Human2.05472615
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.03391815
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02441140
31KDM2B_26808549_Chip-Seq_DND41_Human2.02289435
32* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.00583721
33* FOXP3_21729870_ChIP-Seq_TREG_Human1.99715800
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.99550918
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97332546
36KDM2B_26808549_Chip-Seq_K562_Human1.97069792
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96268955
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.96169357
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95007377
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89500795
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.89293403
42VDR_23849224_ChIP-Seq_CD4+_Human1.89227472
43CIITA_25753668_ChIP-Seq_RAJI_Human1.88588023
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.87981550
45GABP_19822575_ChIP-Seq_HepG2_Human1.86182512
46TFEB_21752829_ChIP-Seq_HELA_Human1.85195912
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83487683
48DCP1A_22483619_ChIP-Seq_HELA_Human1.82894093
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.82097384
50KDM5A_27292631_Chip-Seq_BREAST_Human1.81998645
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81067368
52GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.77353752
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.77062708
54EZH2_22144423_ChIP-Seq_EOC_Human1.76120219
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76117153
56XRN2_22483619_ChIP-Seq_HELA_Human1.73533048
57* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73399028
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73178236
59* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72319340
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70935195
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.69273927
62TCF7_22412390_ChIP-Seq_EML_Mouse1.67709102
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.66634844
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64118360
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.62791508
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.61594814
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.59391837
68* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.58790219
69MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57811457
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.57707977
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57528271
72* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.56600848
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52736232
74RUNX_20019798_ChIP-Seq_JUKART_Human1.51952611
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48793224
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.48613590
77SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46830596
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.46800920
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.46522637
80SPI1_23547873_ChIP-Seq_NB4_Human1.44770435
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44451671
82EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44124728
83RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44124728
84NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43832134
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.43713134
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43498940
87* TTF2_22483619_ChIP-Seq_HELA_Human1.43393544
88YY1_21170310_ChIP-Seq_MESCs_Mouse1.43364679
89E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43314544
90GBX2_23144817_ChIP-Seq_PC3_Human1.43196600
91* LXR_22292898_ChIP-Seq_THP-1_Human1.42551101
92SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42049660
93EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40327150
94ELK1_19687146_ChIP-ChIP_HELA_Human1.39447276
95MYB_21317192_ChIP-Seq_ERMYB_Mouse1.36510523
96CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35690815
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34750627
98AR_21909140_ChIP-Seq_LNCAP_Human1.34562077
99RNF2_27304074_Chip-Seq_ESCs_Mouse1.34538225
100MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.30482941
101SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29362742
102AR_21572438_ChIP-Seq_LNCaP_Human1.28914133
103SPI1_23127762_ChIP-Seq_K562_Human1.27936085
104REST_21632747_ChIP-Seq_MESCs_Mouse1.27575844
105MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27505569
106JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25325154
107MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25004642
108JARID2_20064375_ChIP-Seq_MESCs_Mouse1.24983994
109REST_18959480_ChIP-ChIP_MESCs_Mouse1.23487962
110IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23194541
111EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22615817
112KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21424654
113VDR_21846776_ChIP-Seq_THP-1_Human1.20001396
114ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19967387
115GATA1_19941827_ChIP-Seq_MEL_Mouse1.19483436
116DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18717903
117THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17705828
118AR_19668381_ChIP-Seq_PC3_Human1.17691767
119SMAD3_21741376_ChIP-Seq_HESCs_Human1.16619734
120TP63_17297297_ChIP-ChIP_HaCaT_Human1.16388769
121SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16106420
122PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15839765
123SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15699359
124HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14981709
125PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14942305
126MYC_22102868_ChIP-Seq_BL_Human1.14772041
127GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14339720
128WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14207087
129ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13369705
130WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13228539
131RUNX1_22412390_ChIP-Seq_EML_Mouse1.13196525
132AHR_22903824_ChIP-Seq_MCF-7_Human1.12271038
133PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10666620
134SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10435520
135NCOR1_26117541_ChIP-Seq_K562_Human1.10382154
136TCF4_18268006_ChIP-ChIP_LS174T_Human1.08563491
137TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08275875
138P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08144748
139* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07857875
140CREB1_26743006_Chip-Seq_LNCaP_Human1.07851749
141BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07290079
142MAF_26560356_Chip-Seq_TH1_Human1.06871703
143TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06758487
144SMC4_20622854_ChIP-Seq_HELA_Human1.06174206
145SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04243326
146ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04121332
147ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03278709
148FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03073966
149UTX_26944678_Chip-Seq_JUKART_Human1.03015434
150MYB_26560356_Chip-Seq_TH1_Human1.02939482
151* SRF_21415370_ChIP-Seq_HL-1_Mouse1.02917027
152BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02620338
153EP300_21415370_ChIP-Seq_HL-1_Mouse1.01594702
154EGR1_19032775_ChIP-ChIP_M12_Human1.01292732
155SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00559115
156NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00078055
157ARNT_22903824_ChIP-Seq_MCF-7_Human0.99148503
158ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99133324
159* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98501196
160CTCF_27219007_Chip-Seq_Bcells_Human0.97826963
161MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96928275
162* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96663110
163TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96593394
164SMAD_19615063_ChIP-ChIP_OVARY_Human0.96494495
165SCL_19346495_ChIP-Seq_HPC-7_Human0.95977782
166ELK3_25401928_ChIP-Seq_HUVEC_Human0.95910713
167PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94644412
168ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94477306
169SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94394673
170IRF8_21731497_ChIP-ChIP_J774_Mouse0.94194443
171P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94132115
172GATA2_21666600_ChIP-Seq_HMVEC_Human0.93985386
173VDR_24763502_ChIP-Seq_THP-1_Human0.93527950
174RING1B_27294783_Chip-Seq_NPCs_Mouse0.93446576
175CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93329201
176E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92954323
177BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92725385
178VDR_24787735_ChIP-Seq_THP-1_Human0.92422817
179ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92307672
180SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92276838
181* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92065937
182IRF8_27001747_Chip-Seq_BMDM_Mouse0.89824891
183CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88803959
184EZH2_27304074_Chip-Seq_ESCs_Mouse0.88292798
185CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87956674
186MYB_26560356_Chip-Seq_TH2_Human0.87555693
187OCT4_19829295_ChIP-Seq_ESCs_Human0.85208654
188RXR_22108803_ChIP-Seq_LS180_Human0.84341089
189ESR2_21235772_ChIP-Seq_MCF-7_Human0.83725057
190SMAD4_21741376_ChIP-Seq_HESCs_Human0.83460548
191PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83329352
192P68_20966046_ChIP-Seq_HELA_Human0.82482927
193* SMAD4_21741376_ChIP-Seq_ESCs_Human0.82382008

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog7.99757698
2MP0003011_delayed_dark_adaptation7.88384863
3MP0005253_abnormal_eye_physiology5.16201382
4MP0006072_abnormal_retinal_apoptosis5.08096826
5MP0008057_abnormal_DNA_replication4.38760317
6MP0008058_abnormal_DNA_repair3.96437087
7MP0010094_abnormal_chromosome_stability3.77215634
8MP0003111_abnormal_nucleus_morphology3.71741328
9MP0003077_abnormal_cell_cycle3.47759436
10MP0005195_abnormal_posterior_eye3.24447345
11MP0003693_abnormal_embryo_hatching3.21106492
12MP0004859_abnormal_synaptic_plasticity3.17472012
13MP0002090_abnormal_vision3.11912606
14MP0003718_maternal_effect2.95330659
15MP0003950_abnormal_plasma_membrane2.95041037
16MP0004957_abnormal_blastocyst_morpholog2.88428855
17MP0008260_abnormal_autophagy2.86085829
18MP0001324_abnormal_eye_pigmentation2.73599829
19MP0005423_abnormal_somatic_nervous2.64599725
20MP0003656_abnormal_erythrocyte_physiolo2.38328251
21MP0002229_neurodegeneration2.33910239
22MP0005391_vision/eye_phenotype2.29457661
23MP0001730_embryonic_growth_arrest2.25494000
24MP0008932_abnormal_embryonic_tissue2.17598867
25MP0006035_abnormal_mitochondrial_morpho2.05765341
26MP0002796_impaired_skin_barrier2.05072697
27MP0000350_abnormal_cell_proliferation2.04422910
28MP0000015_abnormal_ear_pigmentation1.99655928
29MP0008877_abnormal_DNA_methylation1.95659922
30MP0002638_abnormal_pupillary_reflex1.90097901
31MP0009697_abnormal_copulation1.87012590
32MP0003786_premature_aging1.85866148
33MP0003221_abnormal_cardiomyocyte_apopto1.85399188
34MP0004270_analgesia1.85098731
35MP0003303_peritoneal_inflammation1.84135612
36MP0005451_abnormal_body_composition1.84125346
37MP0005394_taste/olfaction_phenotype1.83163423
38MP0005499_abnormal_olfactory_system1.83163423
39MP0004233_abnormal_muscle_weight1.81445058
40MP0008007_abnormal_cellular_replicative1.80716109
41MP0005501_abnormal_skin_physiology1.78218466
42MP0002396_abnormal_hematopoietic_system1.69653614
43MP0003828_pulmonary_edema1.69243512
44MP0005380_embryogenesis_phenotype1.68863115
45MP0001672_abnormal_embryogenesis/_devel1.68863115
46MP0003635_abnormal_synaptic_transmissio1.64974328
47MP0000313_abnormal_cell_death1.61243928
48MP0003984_embryonic_growth_retardation1.51577661
49MP0010307_abnormal_tumor_latency1.50948662
50MP0005397_hematopoietic_system_phenotyp1.47812055
51MP0001545_abnormal_hematopoietic_system1.47812055
52MP0008789_abnormal_olfactory_epithelium1.47539549
53MP0001697_abnormal_embryo_size1.47216886
54MP0008961_abnormal_basal_metabolism1.46413713
55MP0004510_myositis1.45415240
56MP0000569_abnormal_digit_pigmentation1.45025322
57MP0002752_abnormal_somatic_nervous1.43570018
58MP0002088_abnormal_embryonic_growth/wei1.42877996
59MP0002398_abnormal_bone_marrow1.41179000
60MP0002080_prenatal_lethality1.40949857
61MP0002882_abnormal_neuron_morphology1.40351646
62MP0001529_abnormal_vocalization1.37146588
63MP0000685_abnormal_immune_system1.36923430
64MP0001502_abnormal_circadian_rhythm1.36046278
65MP0002063_abnormal_learning/memory/cond1.35676205
66MP0004885_abnormal_endolymph1.35152303
67MP0000358_abnormal_cell_content/1.33843247
68MP0005621_abnormal_cell_physiology1.30794914
69MP0006292_abnormal_olfactory_placode1.29505979
70MP0002064_seizures1.29051571
71MP0005384_cellular_phenotype1.26624596
72MP0000703_abnormal_thymus_morphology1.16080567
73MP0005076_abnormal_cell_differentiation1.15933498
74MP0003806_abnormal_nucleotide_metabolis1.15696320
75MP0001486_abnormal_startle_reflex1.15261895
76MP0002019_abnormal_tumor_incidence1.13670364
77MP0009745_abnormal_behavioral_response1.13185894
78MP0002086_abnormal_extraembryonic_tissu1.13185065
79MP0003941_abnormal_skin_development1.11821501
80MP0002722_abnormal_immune_system1.09393579
81MP0001216_abnormal_epidermal_layer1.08830735
82MP0003566_abnormal_cell_adhesion1.08124497
83MP0003329_amyloid_beta_deposits1.06438318
84MP0008995_early_reproductive_senescence1.05183298
85MP0001986_abnormal_taste_sensitivity1.05160777
86MP0002084_abnormal_developmental_patter1.05031426
87MP0002429_abnormal_blood_cell1.03435095
88MP0005395_other_phenotype1.03354278
89MP0001929_abnormal_gametogenesis1.02441592
90MP0002210_abnormal_sex_determination1.02382690
91MP0009046_muscle_twitch1.00564124
92MP0002653_abnormal_ependyma_morphology1.00246689
93MP0009333_abnormal_splenocyte_physiolog1.00064486
94MP0000689_abnormal_spleen_morphology0.99734242
95MP0003045_fibrosis0.99415385
96MP0000465_gastrointestinal_hemorrhage0.98762472
97MP0003880_abnormal_central_pattern0.98640949
98MP0003699_abnormal_female_reproductive0.98510002
99MP0002420_abnormal_adaptive_immunity0.98455244
100MP0009278_abnormal_bone_marrow0.97897400
101MP0005197_abnormal_uvea_morphology0.96892159
102MP0009780_abnormal_chondrocyte_physiolo0.96423736
103MP0002085_abnormal_embryonic_tissue0.96270052
104MP0004130_abnormal_muscle_cell0.96199468
105MP0001819_abnormal_immune_cell0.95663305
106MP0003172_abnormal_lysosome_physiology0.95534123
107MP0002572_abnormal_emotion/affect_behav0.94596965
108MP0004197_abnormal_fetal_growth/weight/0.94334061
109MP0000716_abnormal_immune_system0.93111210
110MP0003705_abnormal_hypodermis_morpholog0.92908576
111MP0003634_abnormal_glial_cell0.92190458
112MP0010352_gastrointestinal_tract_polyps0.91781663
113MP0003075_altered_response_to0.90379982
114MP0004811_abnormal_neuron_physiology0.89381326
115MP0002909_abnormal_adrenal_gland0.87439034
116MP0003890_abnormal_embryonic-extraembry0.86325822
117MP0005000_abnormal_immune_tolerance0.85724429
118MP0003763_abnormal_thymus_physiology0.85657591
119MP0003183_abnormal_peptide_metabolism0.85525352
120MP0003453_abnormal_keratinocyte_physiol0.85411186
121MP0001968_abnormal_touch/_nociception0.84304817
122MP0002723_abnormal_immune_serum0.83295547
123MP0002006_tumorigenesis0.83249131
124MP0002272_abnormal_nervous_system0.81463957
125MP0002734_abnormal_mechanical_nocicepti0.81341347
126MP0002419_abnormal_innate_immunity0.78961783
127MP0001764_abnormal_homeostasis0.78921220
128MP0006036_abnormal_mitochondrial_physio0.78637049
129MP0003690_abnormal_glial_cell0.77310543
130MP0009931_abnormal_skin_appearance0.76668294
131MP0000490_abnormal_crypts_of0.76338786
132MP0008569_lethality_at_weaning0.75856358
133MP0005187_abnormal_penis_morphology0.75174000
134MP0002332_abnormal_exercise_endurance0.74949738
135MP0000751_myopathy0.74939599
136MP0001501_abnormal_sleep_pattern0.74168621
137MP0003191_abnormal_cellular_cholesterol0.73845370
138MP0001853_heart_inflammation0.71604059
139MP0002877_abnormal_melanocyte_morpholog0.69821889
140MP0003300_gastrointestinal_ulcer0.68839533
141MP0003091_abnormal_cell_migration0.68569741
142MP0000604_amyloidosis0.68299582
143MP0000858_altered_metastatic_potential0.66758733
144MP0003646_muscle_fatigue0.66413941
145MP0004019_abnormal_vitamin_homeostasis0.66249524
146MP0010368_abnormal_lymphatic_system0.66158973
147MP0004084_abnormal_cardiac_muscle0.66152176
148MP0002837_dystrophic_cardiac_calcinosis0.65799303
149MP0000653_abnormal_sex_gland0.65070708
150MP0005310_abnormal_salivary_gland0.64799363
151MP0004085_abnormal_heartbeat0.64578180
152MP0005464_abnormal_platelet_physiology0.62605990
153MP0005620_abnormal_muscle_contractility0.61941332
154MP0005166_decreased_susceptibility_to0.61223325
155MP0003633_abnormal_nervous_system0.60523371
156MP0004036_abnormal_muscle_relaxation0.58529865
157MP0006082_CNS_inflammation0.58342904
158MP0010234_abnormal_vibrissa_follicle0.58067147
159MP0009840_abnormal_foam_cell0.58025363
160MP0005386_behavior/neurological_phenoty0.57863378
161MP0004924_abnormal_behavior0.57863378
162MP0004087_abnormal_muscle_fiber0.57093592
163MP0001800_abnormal_humoral_immune0.56583212
164MP0004215_abnormal_myocardial_fiber0.56232444
165MP0003436_decreased_susceptibility_to0.55146644
166MP0004808_abnormal_hematopoietic_stem0.55119133
167MP0002067_abnormal_sensory_capabilities0.54753231
168MP0004947_skin_inflammation0.54364182
169MP0001851_eye_inflammation0.54360064
170MP0003943_abnormal_hepatobiliary_system0.54055647
171MP0001835_abnormal_antigen_presentation0.53752521
172MP0008874_decreased_physiological_sensi0.50146982
173MP0008004_abnormal_stomach_pH0.50097865
174MP0001915_intracranial_hemorrhage0.50072595
175MP0001970_abnormal_pain_threshold0.48886434
176MP0004185_abnormal_adipocyte_glucose0.48475758
177MP0002822_catalepsy0.48445812
178MP0002972_abnormal_cardiac_muscle0.47934207
179MP0001440_abnormal_grooming_behavior0.47683105
180MP0002452_abnormal_antigen_presenting0.47288408
181MP0003866_abnormal_defecation0.46469112
182MP0002735_abnormal_chemical_nociception0.46299461
183MP0002557_abnormal_social/conspecific_i0.45657348
184MP0003638_abnormal_response/metabolism_0.44101378
185MP0001984_abnormal_olfaction0.43657061
186MP0002066_abnormal_motor_capabilities/c0.43648127

Predicted human phenotypes

RankGene SetZ-score
1Bony spicule pigmentary retinopathy (HP:0007737)9.58733247
2Absent rod-and cone-mediated responses on ERG (HP:0007688)9.10839924
3Abnormal rod and cone electroretinograms (HP:0008323)8.86040748
4Pigmentary retinal degeneration (HP:0001146)7.72337436
5Central scotoma (HP:0000603)7.55872950
6Chorioretinal atrophy (HP:0000533)7.37783018
7Pendular nystagmus (HP:0012043)6.82035717
8Abnormality of macular pigmentation (HP:0008002)6.62777104
9Scotoma (HP:0000575)6.45182595
10Dyschromatopsia (HP:0007641)6.42233795
11Attenuation of retinal blood vessels (HP:0007843)5.90827330
12Abolished electroretinogram (ERG) (HP:0000550)5.86537157
13Decreased central vision (HP:0007663)5.39930999
14Type II diabetes mellitus (HP:0005978)4.80908314
15Photophobia (HP:0000613)4.70895042
16Macular degeneration (HP:0000608)4.60844080
17Severe visual impairment (HP:0001141)4.42597831
18Constricted visual fields (HP:0001133)4.30608027
19Keratoconus (HP:0000563)4.26073531
20Increased corneal curvature (HP:0100692)4.26073531
21Posterior subcapsular cataract (HP:0007787)4.22994817
22Cone-rod dystrophy (HP:0000548)4.15851597
23Vitreoretinal degeneration (HP:0000655)3.92723939
24Choroideremia (HP:0001139)3.80045099
25Cholecystitis (HP:0001082)3.69384904
26Abnormal gallbladder physiology (HP:0012438)3.69384904
27Upper limb muscle weakness (HP:0003484)3.62636181
28Birth length less than 3rd percentile (HP:0003561)3.54118284
29Microvesicular hepatic steatosis (HP:0001414)3.45976832
30Chromosomal breakage induced by crosslinking agents (HP:0003221)3.43312746
31Retinitis pigmentosa (HP:0000510)3.39805717
32Chromsome breakage (HP:0040012)3.38619738
33Progressive visual loss (HP:0000529)3.17081065
34Decreased electroretinogram (ERG) amplitude (HP:0000654)2.95898355
35Entropion (HP:0000621)2.95367306
36Subcapsular cataract (HP:0000523)2.76798740
37Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.72915496
38Abnormality of the preputium (HP:0100587)2.69578927
39Poikiloderma (HP:0001029)2.69231747
40Abnormality of the heme biosynthetic pathway (HP:0010472)2.68355178
41Retinal atrophy (HP:0001105)2.56573310
42Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.54959280
43Myelodysplasia (HP:0002863)2.45184100
44Premature ovarian failure (HP:0008209)2.43241001
45Visual hallucinations (HP:0002367)2.35627847
46Progressive external ophthalmoplegia (HP:0000590)2.34426002
47Abnormality of chromosome stability (HP:0003220)2.33143777
48Progressive muscle weakness (HP:0003323)2.25910558
49Mutism (HP:0002300)2.21627699
50Wide nasal bridge (HP:0000431)2.20001659
51Prominent nose (HP:0000448)2.19231759
52Duodenal stenosis (HP:0100867)2.18713779
53Small intestinal stenosis (HP:0012848)2.18713779
54Long palpebral fissure (HP:0000637)2.17744524
55Abnormality of nail color (HP:0100643)2.17347151
56Rough bone trabeculation (HP:0100670)2.16460204
57Oral leukoplakia (HP:0002745)2.16405400
58Facial hemangioma (HP:0000329)2.16326613
59Reticulocytosis (HP:0001923)2.13837825
60Meckel diverticulum (HP:0002245)2.12274353
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.10674447
62Interstitial pulmonary disease (HP:0006530)2.09795743
63Clubbing of toes (HP:0100760)2.09745171
64Fatigue (HP:0012378)2.09661311
65Papillary thyroid carcinoma (HP:0002895)2.09256314
66Squamous cell carcinoma (HP:0002860)2.08082584
67Acute lymphatic leukemia (HP:0006721)2.07815304
68Abnormality of DNA repair (HP:0003254)2.05088741
69Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.01356737
70Abnormality of the ileum (HP:0001549)2.00679501
71Congenital stationary night blindness (HP:0007642)11.9073395
72Cortical dysplasia (HP:0002539)1.99341378
73Capillary hemangiomas (HP:0005306)1.98550437
74Cafe-au-lait spot (HP:0000957)1.98290149
75Leiomyosarcoma (HP:0100243)1.97687973
76Uterine leiomyosarcoma (HP:0002891)1.97687973
77High anterior hairline (HP:0009890)1.97137017
78Ectropion (HP:0000656)1.96801241
79Urethral obstruction (HP:0000796)1.94300482
80Recurrent bacterial skin infections (HP:0005406)1.94047347
81Peripheral hypomyelination (HP:0007182)1.92631291
82Osteomalacia (HP:0002749)1.92428482
83Sparse scalp hair (HP:0002209)1.90883013
84Abnormality of the labia minora (HP:0012880)1.90722979
85Breast hypoplasia (HP:0003187)1.88839581
86Congenital ichthyosiform erythroderma (HP:0007431)1.88285898
87Slow saccadic eye movements (HP:0000514)1.87498511
88Urinary urgency (HP:0000012)1.86172834
89Lip pit (HP:0100267)1.85993300
90Bone marrow hypocellularity (HP:0005528)1.85714058
91Aplastic anemia (HP:0001915)1.84873367
92Genetic anticipation (HP:0003743)1.84867838
93Medulloblastoma (HP:0002885)1.83937791
94Supranuclear gaze palsy (HP:0000605)1.83126276
95Paralysis (HP:0003470)1.81774623
96Osteomyelitis (HP:0002754)1.81747961
97Cholelithiasis (HP:0001081)1.80553299
98Gait imbalance (HP:0002141)1.80055521
99Myokymia (HP:0002411)1.79598864
100Homocystinuria (HP:0002156)1.78964127
101Abnormality of homocysteine metabolism (HP:0010919)1.78964127
102Deep palmar crease (HP:0006191)1.77647128
103Abnormal trabecular bone morphology (HP:0100671)1.77112911
104Epileptic encephalopathy (HP:0200134)1.75847758
105Urticaria (HP:0001025)1.74919529
106Carpal bone hypoplasia (HP:0001498)1.73488572
107Basal cell carcinoma (HP:0002671)1.73009771
108Sparse lateral eyebrow (HP:0005338)1.72295763
109Renal cell carcinoma (HP:0005584)1.71252648
110Ragged-red muscle fibers (HP:0003200)1.71207888
111Deep philtrum (HP:0002002)1.70663340
112Lymphoma (HP:0002665)1.69693836
113Progressive hearing impairment (HP:0001730)1.69638919
114Impaired platelet aggregation (HP:0003540)1.69505755
115Abnormal platelet function (HP:0011869)1.69505755
116Polycythemia (HP:0001901)1.68603170
117Abnormal large intestine physiology (HP:0012700)1.68550249
118Impulsivity (HP:0100710)1.68075055
119Septate vagina (HP:0001153)1.65851579
120Abnormality of macrophages (HP:0004311)1.65666777
121Cutaneous photosensitivity (HP:0000992)1.65436247
122Thrombocytosis (HP:0001894)1.63463765
123Abnormality of the fingertips (HP:0001211)1.63304333
1243-Methylglutaconic aciduria (HP:0003535)1.63265906
125Hypokinesia (HP:0002375)1.62731952
126Abnormality of the duodenum (HP:0002246)1.62602942
127Recurrent abscess formation (HP:0002722)1.62579059
128Progressive cerebellar ataxia (HP:0002073)1.62342875
129Gastrointestinal stroma tumor (HP:0100723)1.60555092
130Increased IgM level (HP:0003496)1.60500459
131Onycholysis (HP:0001806)1.60240054
132Dysmetric saccades (HP:0000641)1.59715934
133Secondary amenorrhea (HP:0000869)1.57783248
134Abnormal gallbladder morphology (HP:0012437)1.56456149
135Long eyelashes (HP:0000527)1.56455331
136Insidious onset (HP:0003587)1.56064527
137Termporal pattern (HP:0011008)1.56064527
138Congenital primary aphakia (HP:0007707)1.55892938
139Macroorchidism (HP:0000053)1.55427336
140Papilledema (HP:0001085)1.47224318
141Optic disc pallor (HP:0000543)1.47015954
142Hyperacusis (HP:0010780)1.46438048
143Horizontal nystagmus (HP:0000666)1.45967954
144Urinary bladder sphincter dysfunction (HP:0002839)1.45885019
145Polar cataract (HP:0010696)1.44969241
146Abnormality of the lower motor neuron (HP:0002366)1.41615401
147Dysdiadochokinesis (HP:0002075)1.38079015
148Congenital sensorineural hearing impairment (HP:0008527)1.37761261
149Depression (HP:0000716)1.35674274
150Truncal ataxia (HP:0002078)1.33183403
151Postural instability (HP:0002172)1.32483282
152Febrile seizures (HP:0002373)1.32288972
153Lower limb amyotrophy (HP:0007210)1.30401384
154Abnormality of binocular vision (HP:0011514)1.27657032
155Diplopia (HP:0000651)1.27657032
156Apathy (HP:0000741)1.27410596
157Cerebral aneurysm (HP:0004944)1.27232606
158Focal seizures (HP:0007359)1.27110060
159Inappropriate behavior (HP:0000719)1.26415056
160Striae distensae (HP:0001065)1.23603102
161Increased cerebral lipofuscin (HP:0011813)1.23494382
162Aortic aneurysm (HP:0004942)1.21130058
163Poor coordination (HP:0002370)1.21013666
164Optic atrophy (HP:0000648)1.20639149
165Nephrogenic diabetes insipidus (HP:0009806)1.19930759
166Hemiplegia (HP:0002301)1.19571585
167Prolonged QT interval (HP:0001657)1.18147345
168Amyotrophic lateral sclerosis (HP:0007354)1.17421231
169Broad-based gait (HP:0002136)1.17103964
170Colitis (HP:0002583)1.16345289
171Hematochezia (HP:0002573)1.14723704
172Heterotopia (HP:0002282)1.13208039
173Severe Myopia (HP:0011003)1.12729437
174Lower limb asymmetry (HP:0100559)1.12320094
175Centrally nucleated skeletal muscle fibers (HP:0003687)1.11556550
176Syncope (HP:0001279)1.11101996
177Hypermetropia (HP:0000540)1.09486369
178Diminished motivation (HP:0000745)1.09382083
179Elfin facies (HP:0004428)1.09341670
180Insomnia (HP:0100785)1.07810324
181Ventricular fibrillation (HP:0001663)1.06924391
182Upper limb amyotrophy (HP:0009129)1.06482753
183Distal upper limb amyotrophy (HP:0007149)1.06482753
184Left ventricular hypertrophy (HP:0001712)1.05133799
185Disinhibition (HP:0000734)1.05114339
186Abnormality of ocular smooth pursuit (HP:0000617)1.04805043
187Hand muscle atrophy (HP:0009130)1.04781418
188Aqueductal stenosis (HP:0002410)1.04735785
189Abnormal social behavior (HP:0012433)1.04548416
190Impaired social interactions (HP:0000735)1.04548416
191Hypoventilation (HP:0002791)1.04539483
192Pointed chin (HP:0000307)1.03496149
193Neuronal loss in central nervous system (HP:0002529)1.03371980
194Intention tremor (HP:0002080)1.01517140

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK14.44721220
2SRPK13.28966195
3SIK23.05926438
4MAP3K92.87337291
5EIF2AK12.72301674
6MARK12.67388549
7CDC72.57526024
8TTK2.55631625
9PRPF4B2.37792393
10BUB12.11688469
11PAK62.11633434
12MAP4K12.07502292
13BRSK22.00116415
14RAF11.94637813
15MAP3K101.89746022
16TAOK11.88053127
17TRIB31.87661348
18CLK11.79840922
19CAMK1G1.79471124
20ERN11.76686858
21MAP2K31.74696623
22MAPK121.73965485
23ARAF1.70466108
24TSSK61.68750323
25BRAF1.68742649
26CAMKK11.63169143
27MST41.59209698
28PLK41.58912773
29SMG11.57988321
30EIF2AK31.48538854
31BRSK11.44843904
32AURKA1.44711188
33CAMK1D1.44259291
34MAP3K41.43888232
35NTRK21.43121106
36TYRO31.41645319
37MAP3K81.40724929
38MAP3K51.34216027
39STK381.32209389
40ICK1.31565589
41CHEK11.31357214
42STK41.31349840
43PDK21.31019277
44PRKCH1.27620646
45PHKG11.26642609
46PHKG21.26642609
47MAPK71.25693801
48IRAK31.24463309
49MINK11.24405357
50KSR21.24031634
51TGFBR21.22462370
52RIPK11.20576036
53PLK21.20568927
54FGFR41.19717692
55CDK121.19176937
56TAOK31.16767139
57RIPK41.16462676
58FGFR21.15376155
59PBK1.15263021
60STK161.15233352
61FES1.14235677
62JAK11.13981365
63PRKD31.13633721
64PIM11.12968469
65TRIM281.12528211
66PLK11.11723023
67SGK31.11043185
68IRAK21.09069436
69DMPK1.08729132
70MAP3K141.04914971
71PKN21.04864052
72CHEK21.04646966
73TIE11.03085783
74TTN1.02382333
75IRAK41.01375347
76ZAK1.01028146
77ALK1.00340857
78PIM21.00209828
79FGR0.99090156
80CDK50.96534667
81MAP3K70.96391598
82CDK40.95055605
83DAPK20.94309938
84FGFR30.93745774
85ATR0.93463456
86DYRK30.93394001
87CDK70.91787377
88EEF2K0.91599028
89PDK10.90606868
90CSF1R0.89463600
91PDGFRA0.88450645
92MAP3K30.88222270
93WEE10.87876574
94STK110.87258230
95RET0.86265069
96AURKB0.85269995
97TYK20.84982394
98MARK20.84040190
99PLK30.83781516
100BMPR20.83214775
101HIPK20.80813765
102CCNB10.80626276
103ATM0.77080922
104SYK0.75558654
105PTK60.75121503
106DYRK1A0.74369285
107SGK4940.74348107
108SGK2230.74348107
109KSR10.73142057
110CAMK40.72373025
111CDK20.71894718
112NEK90.71774383
113RPS6KA20.71698316
114TBK10.70257738
115CDK190.69717861
116LRRK20.68394997
117MAP2K40.68182753
118TXK0.67942388
119MARK30.67030834
120SIK30.66618695
121NME10.66092670
122SCYL20.65302554
123HCK0.64976271
124PRKCZ0.64584326
125MAP3K130.64074668
126PAK10.63952760
127YES10.63944598
128PDGFRB0.62641177
129BMX0.62101309
130MAP2K70.61698692
131CDK10.61381426
132BCR0.60965236
133CAMK10.59217386
134EPHB10.58696375
135PRKCI0.58678353
136AKT30.58169605
137LMTK20.57616942
138IRAK10.57453637
139SGK20.56722502
140STK30.56353729
141PKN10.56214910
142TESK20.56213186
143BTK0.54936267
144PDPK10.53981373
145MELK0.53952797
146NTRK30.53896540
147PRKD10.52807324
148MET0.52602006
149AKT20.52473798
150ITK0.52452968
151KIT0.52032230
152FYN0.51755300
153PRKAA10.50885652
154TAOK20.50543799
155SGK10.50371240
156ERBB20.50120692
157CDK90.49952055
158BLK0.49556402
159SIK10.49181090
160JAK30.48543632
161PRKD20.48478023
162RPS6KA30.48454055
163MAP3K10.48416447
164MAP3K110.47889648
165MTOR0.47692374
166PINK10.47555417
167MAP3K120.46447313
168PAK30.46015080
169LATS20.45515821
170GRK50.44712015
171PRKAA20.43997030
172STK100.43007535
173RPS6KA10.42443126
174PIK3CG0.42213729
175VRK10.40487481

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.27827551
2DNA replication_Homo sapiens_hsa030303.16334778
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.64435814
4Cell cycle_Homo sapiens_hsa041102.53994621
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.33261134
6Basal transcription factors_Homo sapiens_hsa030222.23075224
7Base excision repair_Homo sapiens_hsa034102.12009947
8RNA transport_Homo sapiens_hsa030132.07662019
9Homologous recombination_Homo sapiens_hsa034402.07213279
10Nucleotide excision repair_Homo sapiens_hsa034202.05109084
11Spliceosome_Homo sapiens_hsa030402.00171457
12Phototransduction_Homo sapiens_hsa0474410.5042628
13Fanconi anemia pathway_Homo sapiens_hsa034601.90618974
14mRNA surveillance pathway_Homo sapiens_hsa030151.89925530
15Olfactory transduction_Homo sapiens_hsa047401.86399775
16Synaptic vesicle cycle_Homo sapiens_hsa047211.86349807
17RNA polymerase_Homo sapiens_hsa030201.86182905
18Non-homologous end-joining_Homo sapiens_hsa034501.82433708
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.65172258
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.62151538
21GABAergic synapse_Homo sapiens_hsa047271.58584074
22Circadian entrainment_Homo sapiens_hsa047131.56065125
23Proteasome_Homo sapiens_hsa030501.51769420
24Cholinergic synapse_Homo sapiens_hsa047251.43904049
25Glutamatergic synapse_Homo sapiens_hsa047241.39464692
26Morphine addiction_Homo sapiens_hsa050321.38328599
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.37628901
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.37419809
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.35912506
30RNA degradation_Homo sapiens_hsa030181.33316231
31Shigellosis_Homo sapiens_hsa051311.32477688
32Oocyte meiosis_Homo sapiens_hsa041141.31138699
33Viral carcinogenesis_Homo sapiens_hsa052031.29544587
34Epstein-Barr virus infection_Homo sapiens_hsa051691.26480411
35p53 signaling pathway_Homo sapiens_hsa041151.25816062
36Pyrimidine metabolism_Homo sapiens_hsa002401.24579660
37Hepatitis B_Homo sapiens_hsa051611.19780819
38Dopaminergic synapse_Homo sapiens_hsa047281.18325192
39Long-term potentiation_Homo sapiens_hsa047201.18149530
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16447626
41Oxytocin signaling pathway_Homo sapiens_hsa049211.12260079
42Salivary secretion_Homo sapiens_hsa049701.11563015
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11305766
44Herpes simplex infection_Homo sapiens_hsa051681.10998010
45Apoptosis_Homo sapiens_hsa042101.10630238
46Gastric acid secretion_Homo sapiens_hsa049711.08857293
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.07198070
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06876065
49Dilated cardiomyopathy_Homo sapiens_hsa054141.02125919
50GnRH signaling pathway_Homo sapiens_hsa049121.00991565
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00770722
52B cell receptor signaling pathway_Homo sapiens_hsa046620.96597853
53Renin secretion_Homo sapiens_hsa049240.95560409
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94910276
55Insulin secretion_Homo sapiens_hsa049110.93807572
56Chemokine signaling pathway_Homo sapiens_hsa040620.89093387
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88948526
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88023692
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87891509
60Influenza A_Homo sapiens_hsa051640.87765263
61VEGF signaling pathway_Homo sapiens_hsa043700.87755266
62Type II diabetes mellitus_Homo sapiens_hsa049300.85154813
63Glioma_Homo sapiens_hsa052140.84835224
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84404064
65Regulation of autophagy_Homo sapiens_hsa041400.83736249
66Serotonergic synapse_Homo sapiens_hsa047260.83296998
67Nicotine addiction_Homo sapiens_hsa050330.81837747
68cAMP signaling pathway_Homo sapiens_hsa040240.80595345
69Osteoclast differentiation_Homo sapiens_hsa043800.79557571
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78799881
71Gap junction_Homo sapiens_hsa045400.78155214
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.77327779
73Non-small cell lung cancer_Homo sapiens_hsa052230.77124367
74Legionellosis_Homo sapiens_hsa051340.77089917
75Thyroid cancer_Homo sapiens_hsa052160.76920093
76Measles_Homo sapiens_hsa051620.76750924
77Platelet activation_Homo sapiens_hsa046110.76217941
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75798574
79mTOR signaling pathway_Homo sapiens_hsa041500.75347234
80Folate biosynthesis_Homo sapiens_hsa007900.74980357
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74874074
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74312636
83Protein export_Homo sapiens_hsa030600.73947386
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.71058629
85ErbB signaling pathway_Homo sapiens_hsa040120.69889410
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68816071
87Ribosome_Homo sapiens_hsa030100.68551432
88Estrogen signaling pathway_Homo sapiens_hsa049150.68392235
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68289721
90HTLV-I infection_Homo sapiens_hsa051660.68246622
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67324415
92Long-term depression_Homo sapiens_hsa047300.67324172
93Renal cell carcinoma_Homo sapiens_hsa052110.67229120
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67123156
95Chronic myeloid leukemia_Homo sapiens_hsa052200.66917867
96Phagosome_Homo sapiens_hsa041450.66460045
97MicroRNAs in cancer_Homo sapiens_hsa052060.66317389
98Amphetamine addiction_Homo sapiens_hsa050310.66188562
99Cocaine addiction_Homo sapiens_hsa050300.65774167
100Choline metabolism in cancer_Homo sapiens_hsa052310.64660217
101Prostate cancer_Homo sapiens_hsa052150.64044243
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64015467
103MAPK signaling pathway_Homo sapiens_hsa040100.63716651
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62554804
105Steroid biosynthesis_Homo sapiens_hsa001000.62149654
106One carbon pool by folate_Homo sapiens_hsa006700.61649671
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61644929
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61571818
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61324830
110Small cell lung cancer_Homo sapiens_hsa052220.60706678
111Endometrial cancer_Homo sapiens_hsa052130.60162783
112Insulin resistance_Homo sapiens_hsa049310.59612219
113Pancreatic cancer_Homo sapiens_hsa052120.58917319
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58794095
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58629915
116Calcium signaling pathway_Homo sapiens_hsa040200.58108142
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57823393
118Bladder cancer_Homo sapiens_hsa052190.57183417
119Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57109655
120Circadian rhythm_Homo sapiens_hsa047100.56649637
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56192810
122Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56182891
123Alcoholism_Homo sapiens_hsa050340.56102598
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55550385
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.55016326
126HIF-1 signaling pathway_Homo sapiens_hsa040660.53610963
127T cell receptor signaling pathway_Homo sapiens_hsa046600.53052895
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52428247
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.50973595
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49801888
131Inositol phosphate metabolism_Homo sapiens_hsa005620.49507638
132Tuberculosis_Homo sapiens_hsa051520.49489531
133Colorectal cancer_Homo sapiens_hsa052100.48865389
134Lysine degradation_Homo sapiens_hsa003100.48399209
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48217525
136Endocytosis_Homo sapiens_hsa041440.47827786
137FoxO signaling pathway_Homo sapiens_hsa040680.47644793
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.47501626
139Insulin signaling pathway_Homo sapiens_hsa049100.46194096
140Pentose phosphate pathway_Homo sapiens_hsa000300.45535666
141Viral myocarditis_Homo sapiens_hsa054160.45220018
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45099407
143Ras signaling pathway_Homo sapiens_hsa040140.44970439
144Notch signaling pathway_Homo sapiens_hsa043300.44471079
145NF-kappa B signaling pathway_Homo sapiens_hsa040640.44392892
146Systemic lupus erythematosus_Homo sapiens_hsa053220.44164803
147Toxoplasmosis_Homo sapiens_hsa051450.44084434
148Acute myeloid leukemia_Homo sapiens_hsa052210.43711857
149Prolactin signaling pathway_Homo sapiens_hsa049170.43460989
150Purine metabolism_Homo sapiens_hsa002300.42999181
151Melanogenesis_Homo sapiens_hsa049160.42958214
152Sphingolipid signaling pathway_Homo sapiens_hsa040710.42780182
153Leishmaniasis_Homo sapiens_hsa051400.41998489
154Ovarian steroidogenesis_Homo sapiens_hsa049130.41844374
155Axon guidance_Homo sapiens_hsa043600.40299755
156Dorso-ventral axis formation_Homo sapiens_hsa043200.38829044
157Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38795695
158Thyroid hormone synthesis_Homo sapiens_hsa049180.38632534
159Glucagon signaling pathway_Homo sapiens_hsa049220.38222853
160Pancreatic secretion_Homo sapiens_hsa049720.38221371
161Rap1 signaling pathway_Homo sapiens_hsa040150.37890841
162TNF signaling pathway_Homo sapiens_hsa046680.37580888

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