KLHL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)7.62764745
2axon ensheathment in central nervous system (GO:0032291)7.62764745
3myelination (GO:0042552)5.00272168
4ensheathment of neurons (GO:0007272)4.97129351
5axon ensheathment (GO:0008366)4.97129351
6fatty acid elongation (GO:0030497)4.90123393
7long-chain fatty acid biosynthetic process (GO:0042759)4.47102154
8negative regulation of neurotransmitter secretion (GO:0046929)4.37900796
9negative regulation of neurotransmitter transport (GO:0051589)4.37715144
10detection of molecule of bacterial origin (GO:0032490)4.22888330
11presynaptic membrane assembly (GO:0097105)4.16258553
12negative regulation of cell killing (GO:0031342)4.16059723
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.16059723
14presynaptic membrane organization (GO:0097090)4.14395689
15L-amino acid import (GO:0043092)4.06882296
16neuron cell-cell adhesion (GO:0007158)4.01251277
17synaptic vesicle docking involved in exocytosis (GO:0016081)3.97725388
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.96888760
19neuronal action potential propagation (GO:0019227)3.96268872
20macrophage activation involved in immune response (GO:0002281)3.89230718
21transmission of nerve impulse (GO:0019226)3.82910649
22synaptic vesicle maturation (GO:0016188)3.81638368
23positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.72587786
24dendritic spine morphogenesis (GO:0060997)3.72000374
25renal system development (GO:0072001)3.70759411
26negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.68876402
27regulation of B cell receptor signaling pathway (GO:0050855)3.64829623
28ionotropic glutamate receptor signaling pathway (GO:0035235)3.63247379
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.62807727
30positive regulation of gamma-delta T cell activation (GO:0046645)3.60740030
31regulation of short-term neuronal synaptic plasticity (GO:0048172)3.59484189
32modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.56888206
33positive regulation by organism of defense response of other organism involved in symbiotic interact3.56888206
34modulation by symbiont of host immune response (GO:0052553)3.56888206
35positive regulation by symbiont of host defense response (GO:0052509)3.56888206
36modulation by symbiont of host defense response (GO:0052031)3.56888206
37modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.56888206
38locomotory exploration behavior (GO:0035641)3.56593970
39negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.53557439
40glycerophospholipid catabolic process (GO:0046475)3.51826775
41microglial cell activation (GO:0001774)3.43350755
42establishment of mitochondrion localization (GO:0051654)3.40755155
43apical protein localization (GO:0045176)3.39712893
44synaptic vesicle exocytosis (GO:0016079)3.37449088
45detection of other organism (GO:0098543)3.36388967
46regulation of beta-amyloid formation (GO:1902003)3.36326146
47regulation of neuronal synaptic plasticity (GO:0048168)3.35329636
48negative regulation of protein localization to cell surface (GO:2000009)3.35071118
49regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.34996271
50macrophage activation (GO:0042116)3.34327473
51adult walking behavior (GO:0007628)3.33266393
52regulation of collateral sprouting (GO:0048670)3.32767046
53positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.32059156
54detection of external biotic stimulus (GO:0098581)3.31217137
55regulation of ARF protein signal transduction (GO:0032012)3.30322573
56regulation of synaptic vesicle exocytosis (GO:2000300)3.30319967
57regulation of dendritic spine morphogenesis (GO:0061001)3.29867496
58vocalization behavior (GO:0071625)3.29541120
59nerve growth factor signaling pathway (GO:0038180)3.29380531
60myelin maintenance (GO:0043217)3.27672766
61regulation of long-term neuronal synaptic plasticity (GO:0048169)3.27283253
62peptidyl-tyrosine autophosphorylation (GO:0038083)3.27274856
63protein localization to synapse (GO:0035418)3.25650531
64positive regulation of cellular amide metabolic process (GO:0034250)3.25625195
65glutamate receptor signaling pathway (GO:0007215)3.23182794
66neuron recognition (GO:0008038)3.22930159
67neuronal ion channel clustering (GO:0045161)3.22209832
68gamma-aminobutyric acid signaling pathway (GO:0007214)3.21002876
69oligodendrocyte differentiation (GO:0048709)3.20669421
70cellular extravasation (GO:0045123)3.20174052
71glutamate secretion (GO:0014047)3.16485814
72neuron-neuron synaptic transmission (GO:0007270)3.14439918
73synaptic transmission, glutamatergic (GO:0035249)3.13498287
74asymmetric protein localization (GO:0008105)3.09799271
75neutrophil activation involved in immune response (GO:0002283)3.07468896
76negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.06465791
77negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04642905
78leukocyte migration involved in inflammatory response (GO:0002523)3.04517475
79cerebral cortex radially oriented cell migration (GO:0021799)3.03733822
80negative regulation of axonogenesis (GO:0050771)2.99195002
81regulation of interferon-beta biosynthetic process (GO:0045357)2.99045710
82cerebellar granule cell differentiation (GO:0021707)2.98201245
83regulation of glutamate receptor signaling pathway (GO:1900449)2.96521040
84amino acid import (GO:0043090)2.96444332
85regulation of excitatory postsynaptic membrane potential (GO:0060079)2.95355862
86signal complex assembly (GO:0007172)2.95328294
87positive regulation of membrane potential (GO:0045838)2.94747161
88regulation of dendritic spine development (GO:0060998)2.94677749
89cholesterol biosynthetic process (GO:0006695)2.93876493
90gamma-aminobutyric acid transport (GO:0015812)2.93252285
91response to peptidoglycan (GO:0032494)2.93231161
92positive regulation of Rap GTPase activity (GO:0032854)2.92572872
93response to methylmercury (GO:0051597)2.92415516
94production of molecular mediator involved in inflammatory response (GO:0002532)2.92259221
95negative regulation of lymphocyte mediated immunity (GO:0002707)2.91661979
96substantia nigra development (GO:0021762)2.90069182
97astrocyte development (GO:0014002)2.87595471
98axonal fasciculation (GO:0007413)2.86855581
99regulation of amyloid precursor protein catabolic process (GO:1902991)2.85296401
100neutrophil mediated immunity (GO:0002446)2.84326624
101negative regulation of interleukin-12 production (GO:0032695)2.83713374
102cyclic nucleotide catabolic process (GO:0009214)2.83165677
103regulation of glutamate secretion (GO:0014048)2.82824508
104cellular response to epinephrine stimulus (GO:0071872)2.82288473
105regulation of voltage-gated calcium channel activity (GO:1901385)2.80079270
106mating behavior (GO:0007617)2.79810878
107detection of biotic stimulus (GO:0009595)2.79073658
108dendritic spine organization (GO:0097061)2.78989576
109exploration behavior (GO:0035640)2.78020934
110negative regulation of interleukin-17 production (GO:0032700)2.77315871
111cellular potassium ion homeostasis (GO:0030007)2.76733738
112long-term synaptic potentiation (GO:0060291)2.75980003
113regulation of synapse structural plasticity (GO:0051823)2.75699433
114regulation of gamma-delta T cell activation (GO:0046643)2.75540398
115eye photoreceptor cell differentiation (GO:0001754)2.75379893
116photoreceptor cell differentiation (GO:0046530)2.75379893
117neurotransmitter-gated ion channel clustering (GO:0072578)2.75079901
118negative regulation of synaptic transmission (GO:0050805)2.74869786
119regulation of synaptic vesicle transport (GO:1902803)2.74470636
120regulation of synaptic plasticity (GO:0048167)2.74140517
121dendrite morphogenesis (GO:0048813)2.73854177
122neutrophil activation (GO:0042119)2.72976044
123positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.72889660
124detection of bacterium (GO:0016045)2.71866628
125regulation of postsynaptic membrane potential (GO:0060078)2.71831251
126regulation of T-helper 2 cell differentiation (GO:0045628)2.71075475
127regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.70783209
128long-term memory (GO:0007616)2.70619832
129positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.66919167
130regulation of dopamine metabolic process (GO:0042053)2.66894357
131regulation of catecholamine metabolic process (GO:0042069)2.66894357
132neuron remodeling (GO:0016322)2.66146517
133auditory behavior (GO:0031223)2.65752302
134regulation of regulated secretory pathway (GO:1903305)2.65750296
135membrane assembly (GO:0071709)2.65134553
136positive T cell selection (GO:0043368)2.64734921
137response to interleukin-15 (GO:0070672)2.64152631
138negative regulation of T cell mediated immunity (GO:0002710)2.64098475
139import into cell (GO:0098657)2.63776546
140regulation of cellular amide metabolic process (GO:0034248)2.63767025
141negative regulation of leukocyte mediated immunity (GO:0002704)2.63546412
142positive regulation of macrophage cytokine production (GO:0060907)2.63350877
143glycine transport (GO:0015816)2.63263818
144membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.62526720
145sterol biosynthetic process (GO:0016126)2.62196424
146positive regulation of dendritic spine development (GO:0060999)2.61226485
147negative regulation of amino acid transport (GO:0051956)2.60754962
148long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.60686426
149myeloid leukocyte mediated immunity (GO:0002444)2.60593833
150positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.60413090
151Golgi to endosome transport (GO:0006895)2.60047851
152sodium ion export (GO:0071436)2.59352751
153behavioral response to cocaine (GO:0048148)2.58324529
154positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.57807091
155layer formation in cerebral cortex (GO:0021819)2.57460501
156regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.57456200
157regulation of Rap GTPase activity (GO:0032317)2.57207045
158response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.56945523
159response to host immune response (GO:0052572)2.56945523
160synaptic transmission, dopaminergic (GO:0001963)2.56695673
161neurotransmitter secretion (GO:0007269)2.54666340
162myeloid cell activation involved in immune response (GO:0002275)2.54455747
163cellular response to ethanol (GO:0071361)2.54334762
164positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.53533609
165granulocyte activation (GO:0036230)2.50927384
166negative regulation of glycoprotein biosynthetic process (GO:0010561)2.50285213
167regulation of myeloid leukocyte mediated immunity (GO:0002886)2.49631421
168regulation of leukocyte degranulation (GO:0043300)2.48245972
169antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.48159611
170B cell receptor signaling pathway (GO:0050853)2.47699169
171lipopolysaccharide-mediated signaling pathway (GO:0031663)2.47501141
172positive regulation of mast cell activation (GO:0033005)2.47117979
173regulation of macrophage cytokine production (GO:0010935)2.46871520
174cerebellar Purkinje cell differentiation (GO:0021702)2.45914164
175response to muramyl dipeptide (GO:0032495)2.45816816
176regulation of gamma-delta T cell differentiation (GO:0045586)2.40984070
177leukocyte aggregation (GO:0070486)2.39121415
178negative regulation of immunoglobulin mediated immune response (GO:0002890)2.38388742
179negative regulation of B cell mediated immunity (GO:0002713)2.38388742
180negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.36608275

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.98288029
2GBX2_23144817_ChIP-Seq_PC3_Human3.84941587
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.83700004
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.79076560
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76204178
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76167046
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.72641454
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.64935690
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41675981
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41675981
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38045739
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34025521
13TAF15_26573619_Chip-Seq_HEK293_Human2.33015155
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.30274877
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.29377055
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27848451
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27348972
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21084819
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.19834687
20* RARB_27405468_Chip-Seq_BRAIN_Mouse2.18459366
21GATA1_22025678_ChIP-Seq_K562_Human2.15295837
22RUNX_20019798_ChIP-Seq_JUKART_Human2.15284542
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.14127704
24SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.13193139
25IRF8_22096565_ChIP-ChIP_GC-B_Human2.12693265
26DROSHA_22980978_ChIP-Seq_HELA_Human2.09043860
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07303349
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.06043644
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.05274288
30EZH2_27294783_Chip-Seq_ESCs_Mouse2.04583971
31SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02612485
32REST_21632747_ChIP-Seq_MESCs_Mouse1.96365623
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.94975859
34AR_21572438_ChIP-Seq_LNCaP_Human1.92921714
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85945471
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.78291076
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78228575
38VDR_24787735_ChIP-Seq_THP-1_Human1.76570908
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.76192258
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.75921491
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.71825372
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.71061379
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68047780
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64832569
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63268684
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60415804
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.57854529
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.56993026
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54252227
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53766616
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52169009
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50577323
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47869336
54P300_19829295_ChIP-Seq_ESCs_Human1.46712072
55ER_23166858_ChIP-Seq_MCF-7_Human1.44741203
56SMAD4_21799915_ChIP-Seq_A2780_Human1.44235554
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43738786
58* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43106136
59SPI1_23127762_ChIP-Seq_K562_Human1.41323316
60FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40613159
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40482017
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.38923264
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38201275
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35637312
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.35336753
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34648829
67VDR_22108803_ChIP-Seq_LS180_Human1.34496460
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33701154
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.31083655
70PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30812523
71SCL_19346495_ChIP-Seq_HPC-7_Human1.30454430
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29908312
73STAT3_23295773_ChIP-Seq_U87_Human1.29560914
74FUS_26573619_Chip-Seq_HEK293_Human1.27065766
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24757257
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24352151
77EGR1_19374776_ChIP-ChIP_THP-1_Human1.22722547
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21549395
79* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19706406
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19133458
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18367665
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16994348
83NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16543921
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15768210
85WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15614480
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15544477
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15348769
88GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14975523
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13394494
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12968625
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.12877011
92* TCF4_23295773_ChIP-Seq_U87_Human1.12369327
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11884628
94IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10406194
95PRDM14_20953172_ChIP-Seq_ESCs_Human1.10340892
96IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09923566
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09610134
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09518820
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.09315162
100TP53_16413492_ChIP-PET_HCT116_Human1.08770306
101IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08560632
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.08103726
103CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07017602
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06485143
105AHR_22903824_ChIP-Seq_MCF-7_Human1.04798767
106NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04439265
107NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04439265
108ESR1_20079471_ChIP-ChIP_T-47D_Human1.04436752
109RING1B_27294783_Chip-Seq_ESCs_Mouse1.04172128
110RING1B_27294783_Chip-Seq_NPCs_Mouse1.00984393
111AR_25329375_ChIP-Seq_VCAP_Human1.00811896
112NANOG_18555785_Chip-Seq_ESCs_Mouse0.99723332
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99153406
114RUNX2_22187159_ChIP-Seq_PCA_Human0.98450640
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98188987
116THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98187786
117RNF2_27304074_Chip-Seq_NSC_Mouse0.97601180
118EP300_21415370_ChIP-Seq_HL-1_Mouse0.97452206
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97211178
120CMYC_18555785_Chip-Seq_ESCs_Mouse0.95723914
121PU_27001747_Chip-Seq_BMDM_Mouse0.95590923
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95581138
123KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94587042
124GATA1_19941827_ChIP-Seq_MEL_Mouse0.94473501
125LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94400858
126EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94375462
127FLI1_27457419_Chip-Seq_LIVER_Mouse0.94345926
128FOXO3_23340844_ChIP-Seq_DLD1_Human0.94210618
129TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93321611
130* KDM2B_26808549_Chip-Seq_K562_Human0.92107954
131* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91892190
132NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91571482
133SMAD4_21741376_ChIP-Seq_EPCs_Human0.91513098
134VDR_24763502_ChIP-Seq_THP-1_Human0.90639246
135RXR_22108803_ChIP-Seq_LS180_Human0.90020286
136BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89602044
137E2F1_18555785_Chip-Seq_ESCs_Mouse0.89367626
138TP53_18474530_ChIP-ChIP_U2OS_Human0.89307242
139FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89089411
140LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88668814
141WT1_19549856_ChIP-ChIP_CCG9911_Human0.88244342
142GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88121865
143* AR_19668381_ChIP-Seq_PC3_Human0.88029209
144* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87952297
145PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87594452
146EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87538413
147ZNF274_21170338_ChIP-Seq_K562_Hela0.87036088
148CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86857027
149SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86646506
150SMAD4_21741376_ChIP-Seq_HESCs_Human0.86470521
151TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86140074
152BCAT_22108803_ChIP-Seq_LS180_Human0.85418622
153SMRT_27268052_Chip-Seq_Bcells_Human0.84777448
154RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83808747
155PU1_27457419_Chip-Seq_LIVER_Mouse0.82762345

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.25049832
2MP0003880_abnormal_central_pattern5.05424248
3MP0004270_analgesia4.06466440
4MP0003724_increased_susceptibility_to3.79578938
5MP0000920_abnormal_myelination3.75950728
6MP0003635_abnormal_synaptic_transmissio3.36094168
7MP0003303_peritoneal_inflammation3.34750450
8MP0009745_abnormal_behavioral_response3.02666845
9MP0002064_seizures3.02556082
10MP0002822_catalepsy2.89377633
11MP0001486_abnormal_startle_reflex2.86995096
12MP0002272_abnormal_nervous_system2.85121434
13MP0003329_amyloid_beta_deposits2.77069713
14MP0002063_abnormal_learning/memory/cond2.73023504
15MP0003690_abnormal_glial_cell2.51753952
16MP0009046_muscle_twitch2.50419273
17MP0001529_abnormal_vocalization2.50099677
18MP0002572_abnormal_emotion/affect_behav2.36148083
19MP0004885_abnormal_endolymph2.32665662
20MP0005423_abnormal_somatic_nervous2.29135614
21MP0003436_decreased_susceptibility_to2.22853305
22MP0002734_abnormal_mechanical_nocicepti2.21045375
23MP0000778_abnormal_nervous_system2.19520575
24MP0001905_abnormal_dopamine_level2.14207353
25MP0003172_abnormal_lysosome_physiology2.11832719
26MP0002419_abnormal_innate_immunity2.08819845
27MP0004947_skin_inflammation2.05129061
28MP0000569_abnormal_digit_pigmentation2.01444702
29MP0006082_CNS_inflammation2.00934809
30MP0004742_abnormal_vestibular_system1.98007717
31MP0001440_abnormal_grooming_behavior1.97556998
32MP0001968_abnormal_touch/_nociception1.97488060
33MP0008877_abnormal_DNA_methylation1.97444022
34MP0005409_darkened_coat_color1.84711285
35MP0001835_abnormal_antigen_presentation1.81802664
36MP0001501_abnormal_sleep_pattern1.77457886
37MP0003634_abnormal_glial_cell1.77087989
38MP0004142_abnormal_muscle_tone1.76767809
39MP0003828_pulmonary_edema1.73846901
40MP0003191_abnormal_cellular_cholesterol1.72653462
41MP0005386_behavior/neurological_phenoty1.69571872
42MP0004924_abnormal_behavior1.69571872
43MP0001485_abnormal_pinna_reflex1.66637486
44MP0005000_abnormal_immune_tolerance1.65807366
45MP0003183_abnormal_peptide_metabolism1.64120227
46MP0005025_abnormal_response_to1.63191160
47MP0009785_altered_susceptibility_to1.63165508
48MP0001970_abnormal_pain_threshold1.61720065
49MP0002067_abnormal_sensory_capabilities1.61121348
50MP0009780_abnormal_chondrocyte_physiolo1.60796514
51MP0001800_abnormal_humoral_immune1.57638293
52MP0002396_abnormal_hematopoietic_system1.57067721
53MP0005171_absent_coat_pigmentation1.57052376
54MP0003632_abnormal_nervous_system1.56655643
55MP0000955_abnormal_spinal_cord1.56608029
56MP0003300_gastrointestinal_ulcer1.56571741
57MP0002736_abnormal_nociception_after1.55565580
58MP0008569_lethality_at_weaning1.54568540
59MP0002229_neurodegeneration1.52975640
60MP0002733_abnormal_thermal_nociception1.52346788
61MP0003950_abnormal_plasma_membrane1.51302428
62MP0002735_abnormal_chemical_nociception1.51231700
63MP0002723_abnormal_immune_serum1.47993716
64MP0003631_nervous_system_phenotype1.46813565
65MP0002882_abnormal_neuron_morphology1.46452656
66MP0002420_abnormal_adaptive_immunity1.45960270
67MP0000604_amyloidosis1.45791653
68MP0002066_abnormal_motor_capabilities/c1.45141560
69MP0003633_abnormal_nervous_system1.43747268
70MP0001819_abnormal_immune_cell1.43092551
71MP0005671_abnormal_response_to1.42527320
72MP0001790_abnormal_immune_system1.41435981
73MP0005387_immune_system_phenotype1.41435981
74MP0002452_abnormal_antigen_presenting1.39956844
75MP0001986_abnormal_taste_sensitivity1.36802674
76MP0000465_gastrointestinal_hemorrhage1.34652952
77MP0005166_decreased_susceptibility_to1.28508216
78MP0004811_abnormal_neuron_physiology1.22283172
79MP0010678_abnormal_skin_adnexa1.22269452
80MP0005248_abnormal_Harderian_gland1.22105196
81MP0000685_abnormal_immune_system1.21962638
82MP0003045_fibrosis1.21346087
83MP0002557_abnormal_social/conspecific_i1.19254980
84MP0002184_abnormal_innervation1.19209794
85MP0001533_abnormal_skeleton_physiology1.18071782
86MP0003136_yellow_coat_color1.18013730
87MP0004484_altered_response_of1.17512082
88MP0002148_abnormal_hypersensitivity_rea1.17366633
89MP0005167_abnormal_blood-brain_barrier1.16702992
90MP0005551_abnormal_eye_electrophysiolog1.16520898
91MP0000566_synostosis1.15812850
92MP0004883_abnormal_blood_vessel1.15149939
93MP0003763_abnormal_thymus_physiology1.13777055
94MP0005310_abnormal_salivary_gland1.13617461
95MP0005410_abnormal_fertilization1.10664526
96MP0001177_atelectasis1.09076863
97MP0001963_abnormal_hearing_physiology1.09007196
98MP0005646_abnormal_pituitary_gland1.07870048
99MP0003448_altered_tumor_morphology1.05917308
100MP0010234_abnormal_vibrissa_follicle1.05276906
101MP0004130_abnormal_muscle_cell1.04948949
102MP0005164_abnormal_response_to1.03817157
103MP0005464_abnormal_platelet_physiology1.03399073
104MP0002152_abnormal_brain_morphology1.03066371
105MP0001845_abnormal_inflammatory_respons1.02952261
106MP0001851_eye_inflammation1.00849715
107MP0002405_respiratory_system_inflammati0.98626652
108MP0004043_abnormal_pH_regulation0.97702217
109MP0005397_hematopoietic_system_phenotyp0.97117664
110MP0001545_abnormal_hematopoietic_system0.97117664
111MP0000716_abnormal_immune_system0.96835138
112MP0005388_respiratory_system_phenotype0.94474622
113MP0002133_abnormal_respiratory_system0.94474622
114MP0002998_abnormal_bone_remodeling0.94043627
115MP0003656_abnormal_erythrocyte_physiolo0.93641589
116MP0002752_abnormal_somatic_nervous0.93627750
117MP0008004_abnormal_stomach_pH0.93127107
118MP0003075_altered_response_to0.92161229
119MP0004510_myositis0.91320678
120MP0001502_abnormal_circadian_rhythm0.90111781
121MP0008874_decreased_physiological_sensi0.89984875
122MP0001984_abnormal_olfaction0.87326611
123MP0006276_abnormal_autonomic_nervous0.87254588
124MP0002398_abnormal_bone_marrow0.86805073
125MP0005623_abnormal_meninges_morphology0.85968239
126MP0004145_abnormal_muscle_electrophysio0.84932511
127MP0009764_decreased_sensitivity_to0.83728440
128MP0003866_abnormal_defecation0.81560913
129MP0005645_abnormal_hypothalamus_physiol0.80694183
130MP0003195_calcinosis0.78471181
131MP0001299_abnormal_eye_distance/0.78112000
132MP0000462_abnormal_digestive_system0.77775917
133MP0004147_increased_porphyrin_level0.76948176
134MP0000383_abnormal_hair_follicle0.76910236
135MP0002069_abnormal_eating/drinking_beha0.76350808
136MP0004858_abnormal_nervous_system0.76226436
137MP0001188_hyperpigmentation0.75019333
138MP0002090_abnormal_vision0.72786542
139MP0000747_muscle_weakness0.71863910
140MP0005535_abnormal_body_temperature0.69330907
141MP0003879_abnormal_hair_cell0.67888326
142MP0003938_abnormal_ear_development0.66070431
143MP0004085_abnormal_heartbeat0.65675599
144MP0001346_abnormal_lacrimal_gland0.65510154
145MP0001664_abnormal_digestion0.64315255
146MP0005195_abnormal_posterior_eye0.64261437
147MP0000013_abnormal_adipose_tissue0.63094895
148MP0000026_abnormal_inner_ear0.61213608
149MP0004185_abnormal_adipocyte_glucose0.60986844
150MP0004134_abnormal_chest_morphology0.59868662
151MP0000631_abnormal_neuroendocrine_gland0.57364250
152MP0003137_abnormal_impulse_conducting0.56192938
153MP0002909_abnormal_adrenal_gland0.56040541
154MP0000003_abnormal_adipose_tissue0.55474045
155MP0003787_abnormal_imprinting0.54954564
156MP0005451_abnormal_body_composition0.54657647
157MP0008260_abnormal_autophagy0.51791360
158MP0002295_abnormal_pulmonary_circulatio0.51633983
159MP0008872_abnormal_physiological_respon0.50006914
160MP0001661_extended_life_span0.49299450
161MP0003861_abnormal_nervous_system0.49153751

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)6.08627696
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.78817313
3Degeneration of the lateral corticospinal tracts (HP:0002314)5.78817313
4Myokymia (HP:0002411)5.48292505
5Focal motor seizures (HP:0011153)5.09381418
6Cerebral inclusion bodies (HP:0100314)4.94801323
7Abnormality of the corticospinal tract (HP:0002492)4.76521205
8Back pain (HP:0003418)4.45226333
9Supranuclear gaze palsy (HP:0000605)4.33008314
10Sensory axonal neuropathy (HP:0003390)4.13278172
11Eczematoid dermatitis (HP:0000976)4.06385759
12Retrobulbar optic neuritis (HP:0100654)3.88831032
13Optic neuritis (HP:0100653)3.88831032
14Dysmetria (HP:0001310)3.85102841
15Spastic gait (HP:0002064)3.83699000
16Orchitis (HP:0100796)3.76555503
17Intention tremor (HP:0002080)3.73707130
18Focal seizures (HP:0007359)3.71025410
19Recurrent bacterial skin infections (HP:0005406)3.66911176
20Peripheral hypomyelination (HP:0007182)3.57699123
21Insidious onset (HP:0003587)3.55797690
22Termporal pattern (HP:0011008)3.55797690
23Myositis (HP:0100614)3.55761800
24Recurrent abscess formation (HP:0002722)3.54393472
25Recurrent gram-negative bacterial infections (HP:0005420)3.52957897
26Parakeratosis (HP:0001036)3.46862245
27Atonic seizures (HP:0010819)3.33552640
28Epileptic encephalopathy (HP:0200134)3.31596859
29Ankle clonus (HP:0011448)3.30280097
30Scanning speech (HP:0002168)3.25226209
31Abnormality of macrophages (HP:0004311)3.12325922
32Onion bulb formation (HP:0003383)3.11995495
33Action tremor (HP:0002345)2.98373286
34Akinesia (HP:0002304)2.98193536
35Retinal dysplasia (HP:0007973)2.92438044
36Papilledema (HP:0001085)2.89140223
37Broad-based gait (HP:0002136)2.84865600
38Hyperventilation (HP:0002883)2.83808607
39Abnormality of the labia minora (HP:0012880)2.74472765
40Thickened helices (HP:0000391)2.72924161
41Dialeptic seizures (HP:0011146)2.71297894
42Stomatitis (HP:0010280)2.71224838
43Lower limb muscle weakness (HP:0007340)2.71184050
44Keratoconjunctivitis sicca (HP:0001097)2.68516665
45Gaze-evoked nystagmus (HP:0000640)2.66076477
46Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.65947013
47Hemiplegia (HP:0002301)2.65679424
48Dysdiadochokinesis (HP:0002075)2.58246678
49Megalencephaly (HP:0001355)2.54213239
50Absence seizures (HP:0002121)2.53538676
51Visual hallucinations (HP:0002367)2.52666165
52Mediastinal lymphadenopathy (HP:0100721)2.52293167
53Cerebral hemorrhage (HP:0001342)2.49571289
54Abnormality of cochlea (HP:0000375)2.49051094
55Urinary urgency (HP:0000012)2.47651890
56Pheochromocytoma (HP:0002666)2.47327943
57Bilateral sensorineural hearing impairment (HP:0008619)2.47120880
58Keratoconjunctivitis (HP:0001096)2.47054361
59Ventricular fibrillation (HP:0001663)2.45386478
60Generalized tonic-clonic seizures (HP:0002069)2.45155599
61Urinary bladder sphincter dysfunction (HP:0002839)2.43540621
62Gingivitis (HP:0000230)2.43135999
63Alacrima (HP:0000522)2.40716110
64Clumsiness (HP:0002312)2.39998242
65Abnormal auditory evoked potentials (HP:0006958)2.39781389
66Impaired vibration sensation in the lower limbs (HP:0002166)2.38874938
67Generalized myoclonic seizures (HP:0002123)2.33850862
68Cerebral hypomyelination (HP:0006808)2.33820047
69Progressive cerebellar ataxia (HP:0002073)2.31812238
70Anxiety (HP:0000739)2.31748454
71Spontaneous hematomas (HP:0007420)2.29139914
72Increased circulating renin level (HP:0000848)2.29002952
73Obstructive sleep apnea (HP:0002870)2.28209152
74Gastrointestinal infarctions (HP:0005244)2.26946940
75Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.25525709
76Episodic fever (HP:0001954)2.25117703
77Amyloidosis (HP:0011034)2.23026368
78Spastic tetraparesis (HP:0001285)2.19572888
79Slow saccadic eye movements (HP:0000514)2.19088696
80Neuroendocrine neoplasm (HP:0100634)2.18258735
81Bowel incontinence (HP:0002607)2.17579540
82Memory impairment (HP:0002354)2.17337867
83Recurrent skin infections (HP:0001581)2.16167540
84Progressive inability to walk (HP:0002505)2.15455754
85Status epilepticus (HP:0002133)2.14362392
86Curly hair (HP:0002212)2.12953296
87Clonus (HP:0002169)2.12177373
88Papillary thyroid carcinoma (HP:0002895)2.10632832
89Mutism (HP:0002300)2.09778887
90Aplasia involving bones of the upper limbs (HP:0009823)2.08253136
91Aplasia of the phalanges of the hand (HP:0009802)2.08253136
92Aplasia involving bones of the extremities (HP:0009825)2.08253136
93Abnormality of the endocardium (HP:0004306)2.07986774
94Neuronal loss in central nervous system (HP:0002529)2.07932358
95Truncal ataxia (HP:0002078)2.07788938
96Menstrual irregularities (HP:0000858)2.06665930
97Abnormal eating behavior (HP:0100738)2.06413883
98Pulmonary embolism (HP:0002204)2.06278591
99Excessive salivation (HP:0003781)2.06099978
100Drooling (HP:0002307)2.06099978
101Hypoplastic labia majora (HP:0000059)2.03954557
102Hemoptysis (HP:0002105)2.03742589
103Meningitis (HP:0001287)2.02199298
104Recurrent fungal infections (HP:0002841)2.02134190
105Abnormal large intestine physiology (HP:0012700)2.02034007
106Leukodystrophy (HP:0002415)2.01305976
107Postural instability (HP:0002172)2.01007008
108T lymphocytopenia (HP:0005403)1.99791043
109Spastic paraparesis (HP:0002313)1.99766305
110Torticollis (HP:0000473)1.98471953
111Febrile seizures (HP:0002373)1.97823691
112Poor eye contact (HP:0000817)1.97136926
113Morphological abnormality of the inner ear (HP:0011390)1.96879585
114Widely spaced teeth (HP:0000687)1.95485138
115Type II lissencephaly (HP:0007260)1.95238171
116Anteriorly placed anus (HP:0001545)1.94640861
117Abnormality of binocular vision (HP:0011514)1.93550397
118Diplopia (HP:0000651)1.93550397
119Aneurysm (HP:0002617)1.92504853
120Abnormality of glycolysis (HP:0004366)1.92378527
121Increased serum pyruvate (HP:0003542)1.92378527
122Autoamputation (HP:0001218)1.90979955
123Depression (HP:0000716)1.89750619
124Absent speech (HP:0001344)1.89404068
125Birth length less than 3rd percentile (HP:0003561)1.89338702
126Morphological abnormality of the pyramidal tract (HP:0002062)1.88893419
127Hemiparesis (HP:0001269)1.88048540
128Abnormality of the periventricular white matter (HP:0002518)1.87624203
129Metabolic alkalosis (HP:0200114)1.87595894
130Abnormality of glycolipid metabolism (HP:0010969)1.87154345
131Abnormality of liposaccharide metabolism (HP:0010968)1.87154345
132Abnormality of glycosphingolipid metabolism (HP:0004343)1.87154345
133Resting tremor (HP:0002322)1.86924012
134Hammertoe (HP:0001765)1.86228026
135Abnormality of the labia majora (HP:0012881)1.85924285
136Amblyopia (HP:0000646)1.85839214
137Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.84409732
138Bradykinesia (HP:0002067)1.84391375
139Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.83805072
140Decreased lacrimation (HP:0000633)1.83584868
141Pulmonary infiltrates (HP:0002113)1.83234243
142Abnormality of T cell number (HP:0011839)1.83020391
143Vasculitis (HP:0002633)1.80910529
144Blue irides (HP:0000635)1.80842007
145Arterial thrombosis (HP:0004420)1.80029374
146Apathy (HP:0000741)1.79786490
147Focal dystonia (HP:0004373)1.79625402
148Partial agenesis of the corpus callosum (HP:0001338)1.78690360
149Gingival bleeding (HP:0000225)1.78194486
150Urinary incontinence (HP:0000020)1.77649619
151Delusions (HP:0000746)1.77541451
152Cystic liver disease (HP:0006706)1.77494727
153Impaired social interactions (HP:0000735)1.77242879
154Abnormal social behavior (HP:0012433)1.77242879
155Obstructive lung disease (HP:0006536)1.77118318
156Chronic obstructive pulmonary disease (HP:0006510)1.77118318
157Congenital ichthyosiform erythroderma (HP:0007431)1.77062880
158Abnormality of saccadic eye movements (HP:0000570)1.76630139
159Poor speech (HP:0002465)1.76194755
160Epileptiform EEG discharges (HP:0011182)1.74176052

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.57922519
2EPHA44.27515552
3OXSR13.67081671
4SGK22.49049411
5NTRK32.43361123
6TNIK2.37228217
7MAP3K92.27725754
8CDK192.20659904
9SGK32.10904355
10BCR2.05581372
11PRPF4B2.04717022
12NTRK12.04500056
13EPHB12.04084472
14PNCK2.03041450
15MARK11.98565861
16PAK61.93506386
17MAP3K131.92661493
18KSR21.83087444
19PKN11.71307057
20FGFR21.71091425
21BLK1.71076511
22AKT31.67808585
23WNK41.66168268
24UHMK11.57527546
25ARAF1.55118453
26CASK1.52556982
27FGR1.51883211
28MET1.49475731
29RIPK41.46643513
30CAMK2B1.45451105
31WNK11.43891906
32MAPKAPK51.42537814
33MAP3K41.42257629
34CSK1.42172234
35CDK51.39468935
36NEK61.39405684
37MINK11.37782053
38JAK21.36646661
39IRAK41.35965294
40DAPK21.35212623
41TYRO31.29142334
42MAP3K141.21133122
43JAK11.20376892
44ICK1.19809437
45CAMKK21.15797527
46MAP2K31.15588385
47PRKD31.13860763
48NTRK21.13020685
49CSNK1G21.13010011
50ROCK21.12072362
51CSNK1G31.10832647
52FES1.10492927
53TYK21.09707134
54SGK4941.08382625
55SGK2231.08382625
56CAMK2A1.07314033
57PBK1.06609662
58CSF1R1.06469834
59MAP2K71.05000054
60CSNK1A1L1.04708182
61MAP3K61.03619736
62CAMK2D1.03390500
63BMPR21.02938961
64MAP4K11.01221393
65STK380.98304854
66CDK140.96557115
67KSR10.96096597
68PAK30.94501313
69MARK20.94199593
70PTK2B0.94094581
71IKBKE0.94039281
72MAP3K110.92503780
73HCK0.92030403
74CLK10.90949483
75PLK20.88762283
76TNK20.88358193
77MAP3K20.88051193
78CDK150.87647754
79LIMK10.87232267
80SYK0.85068581
81CDK180.84900933
82ZAP700.84149301
83MAPK130.81545939
84STK110.80372415
85CSNK1G10.79821809
86PDPK10.79771246
87TAOK30.78870265
88PRKCQ0.77664471
89CDK11A0.76927049
90CAMK2G0.76096778
91GRK60.73217178
92MATK0.73074287
93GRK50.72424924
94FGFR30.68765313
95MAP2K40.67817047
96RAF10.67282729
97FYN0.65959866
98STK38L0.65578340
99RIPK10.64924981
100JAK30.64343318
101PRKCH0.64231414
102MAP3K50.63492152
103PRKCE0.63257228
104MAP3K120.62066528
105PRKCG0.61837853
106PHKG20.61628681
107PHKG10.61628681
108LYN0.61444456
109BRAF0.61442659
110CAMK1G0.60878212
111STK240.60066301
112ALK0.59633301
113PDK10.57915385
114YES10.57294182
115TXK0.55969091
116CAMKK10.55641271
117CAMK1D0.55019401
118LATS20.54200989
119SGK10.53195967
120MAPK120.53058302
121BTK0.53042112
122CAMK40.51022596
123MAP2K60.50979644
124TAOK10.50356059
125RET0.49996505
126IRAK10.49832954
127PRKD10.48518038
128DYRK1A0.47843769
129PDGFRB0.45347075
130CAMK10.45012116
131MAP3K30.44863306
132ERN10.42579811
133MOS0.42315823
134DMPK0.41020370
135NME10.40116429
136IRAK20.39962995
137MAPK100.39598419
138DYRK20.39553292
139TGFBR20.39149573
140CSNK1A10.37457543
141MUSK0.37317005
142CSNK1D0.36624275
143PRKG10.36448195
144PINK10.36205464
145PRKCZ0.33420515
146MAP3K10.33162751
147PRKACB0.32528970
148ERBB40.32513770
149RPS6KA30.30968164

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.95125593
2Steroid biosynthesis_Homo sapiens_hsa001002.61208639
3Nicotine addiction_Homo sapiens_hsa050332.53536110
4Glutamatergic synapse_Homo sapiens_hsa047242.39093203
5GABAergic synapse_Homo sapiens_hsa047272.36883207
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.23825479
7Morphine addiction_Homo sapiens_hsa050322.22775351
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20241181
9Fatty acid elongation_Homo sapiens_hsa000622.15165718
10Circadian entrainment_Homo sapiens_hsa047132.10959723
11Long-term potentiation_Homo sapiens_hsa047201.99688218
12Synaptic vesicle cycle_Homo sapiens_hsa047211.97354533
13Olfactory transduction_Homo sapiens_hsa047401.94380411
14Osteoclast differentiation_Homo sapiens_hsa043801.86825044
15Salivary secretion_Homo sapiens_hsa049701.82261043
16Ether lipid metabolism_Homo sapiens_hsa005651.81535800
17Serotonergic synapse_Homo sapiens_hsa047261.81356428
18Amphetamine addiction_Homo sapiens_hsa050311.79898491
19Axon guidance_Homo sapiens_hsa043601.76311565
20Leishmaniasis_Homo sapiens_hsa051401.75772414
21Long-term depression_Homo sapiens_hsa047301.75477917
22Dopaminergic synapse_Homo sapiens_hsa047281.73158200
23B cell receptor signaling pathway_Homo sapiens_hsa046621.60108844
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.59633157
25Nitrogen metabolism_Homo sapiens_hsa009101.54622160
26Cholinergic synapse_Homo sapiens_hsa047251.53741427
27Tuberculosis_Homo sapiens_hsa051521.51893117
28Renin secretion_Homo sapiens_hsa049241.48122666
29Gastric acid secretion_Homo sapiens_hsa049711.47904384
30Cocaine addiction_Homo sapiens_hsa050301.41406890
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40519984
32Collecting duct acid secretion_Homo sapiens_hsa049661.36669915
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35642003
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32597435
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28667973
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28187952
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23813875
38Oxytocin signaling pathway_Homo sapiens_hsa049211.23040673
39Taste transduction_Homo sapiens_hsa047421.18844932
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16998337
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16166400
42Non-small cell lung cancer_Homo sapiens_hsa052231.16000444
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12637948
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.12517398
45Calcium signaling pathway_Homo sapiens_hsa040201.12401184
46Gap junction_Homo sapiens_hsa045401.10733501
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.10710842
48Staphylococcus aureus infection_Homo sapiens_hsa051501.10683842
49Insulin secretion_Homo sapiens_hsa049111.10519715
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08846311
51Butanoate metabolism_Homo sapiens_hsa006501.08789074
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.05298146
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.04538710
54T cell receptor signaling pathway_Homo sapiens_hsa046601.03689421
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03575674
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03070535
57cAMP signaling pathway_Homo sapiens_hsa040241.00958166
58GnRH signaling pathway_Homo sapiens_hsa049121.00465351
59Renal cell carcinoma_Homo sapiens_hsa052110.99465908
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99396278
61ErbB signaling pathway_Homo sapiens_hsa040120.99272480
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.98983836
63Vibrio cholerae infection_Homo sapiens_hsa051100.98902214
64Sphingolipid metabolism_Homo sapiens_hsa006000.98730189
65Dorso-ventral axis formation_Homo sapiens_hsa043200.98717352
66Prolactin signaling pathway_Homo sapiens_hsa049170.97733403
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97267459
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.96505214
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96401129
70Oxidative phosphorylation_Homo sapiens_hsa001900.91720216
71Protein export_Homo sapiens_hsa030600.90969622
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89626885
73Legionellosis_Homo sapiens_hsa051340.89590266
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89262235
75Alzheimers disease_Homo sapiens_hsa050100.89171752
76Phagosome_Homo sapiens_hsa041450.88740853
77Toxoplasmosis_Homo sapiens_hsa051450.88037049
78Caffeine metabolism_Homo sapiens_hsa002320.86232534
79Salmonella infection_Homo sapiens_hsa051320.84116441
80TNF signaling pathway_Homo sapiens_hsa046680.84091560
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83622193
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83536455
83Sulfur metabolism_Homo sapiens_hsa009200.83081982
84Endometrial cancer_Homo sapiens_hsa052130.82872416
85Acute myeloid leukemia_Homo sapiens_hsa052210.82688333
86Malaria_Homo sapiens_hsa051440.82097303
87Inositol phosphate metabolism_Homo sapiens_hsa005620.81907002
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81097184
89Platelet activation_Homo sapiens_hsa046110.80644504
90Ras signaling pathway_Homo sapiens_hsa040140.79223776
91Phototransduction_Homo sapiens_hsa047440.78996086
92Pancreatic secretion_Homo sapiens_hsa049720.78241782
93Pancreatic cancer_Homo sapiens_hsa052120.77550960
94Choline metabolism in cancer_Homo sapiens_hsa052310.77307763
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.77288229
96Hematopoietic cell lineage_Homo sapiens_hsa046400.76352911
97Cardiac muscle contraction_Homo sapiens_hsa042600.74283632
98Influenza A_Homo sapiens_hsa051640.74117495
99Melanogenesis_Homo sapiens_hsa049160.73871078
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72990288
101Vitamin B6 metabolism_Homo sapiens_hsa007500.72745944
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.72082629
103Pertussis_Homo sapiens_hsa051330.71556239
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.71253177
105Endocytosis_Homo sapiens_hsa041440.70067586
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68894684
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66819387
108Measles_Homo sapiens_hsa051620.66533991
109Chronic myeloid leukemia_Homo sapiens_hsa052200.66323758
110Tight junction_Homo sapiens_hsa045300.65211369
111FoxO signaling pathway_Homo sapiens_hsa040680.64572694
112Ovarian steroidogenesis_Homo sapiens_hsa049130.64159111
113Estrogen signaling pathway_Homo sapiens_hsa049150.63051984
114Glioma_Homo sapiens_hsa052140.62350469
115mTOR signaling pathway_Homo sapiens_hsa041500.61936850
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61493869
117Parkinsons disease_Homo sapiens_hsa050120.60832467
118Hepatitis B_Homo sapiens_hsa051610.60213154
119Hepatitis C_Homo sapiens_hsa051600.59998457
120Circadian rhythm_Homo sapiens_hsa047100.59132072
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.58409877
122Amoebiasis_Homo sapiens_hsa051460.57695535
123Histidine metabolism_Homo sapiens_hsa003400.56066961
124MAPK signaling pathway_Homo sapiens_hsa040100.55949687
125Linoleic acid metabolism_Homo sapiens_hsa005910.52529694
126Fatty acid biosynthesis_Homo sapiens_hsa000610.51175648
127Prion diseases_Homo sapiens_hsa050200.50213933
128Rheumatoid arthritis_Homo sapiens_hsa053230.49777316
129Thyroid hormone synthesis_Homo sapiens_hsa049180.48816637
130Type II diabetes mellitus_Homo sapiens_hsa049300.46992969
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45913700
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45761718
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44995587
134VEGF signaling pathway_Homo sapiens_hsa043700.44116056
135Rap1 signaling pathway_Homo sapiens_hsa040150.43933277
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42925538
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42765025
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40577675
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38043354
140Chemokine signaling pathway_Homo sapiens_hsa040620.37212492
141Bile secretion_Homo sapiens_hsa049760.36842463
142Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35623773
143African trypanosomiasis_Homo sapiens_hsa051430.34827325
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34824520
145Glycerolipid metabolism_Homo sapiens_hsa005610.34502836
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34437769
147Alcoholism_Homo sapiens_hsa050340.34127526

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