KLHL21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)4.72208863
2actin-myosin filament sliding (GO:0033275)4.72208863
3sarcomere organization (GO:0045214)4.44430503
42-oxoglutarate metabolic process (GO:0006103)4.30215554
5lysine metabolic process (GO:0006553)4.27910172
6lysine catabolic process (GO:0006554)4.27910172
7regulation of skeletal muscle contraction (GO:0014819)4.26865333
8carnitine shuttle (GO:0006853)4.20986234
9fatty acid transmembrane transport (GO:1902001)4.06601180
10L-phenylalanine metabolic process (GO:0006558)4.04522116
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.04522116
12valine metabolic process (GO:0006573)4.04148166
13low-density lipoprotein particle clearance (GO:0034383)3.99326874
14serine family amino acid catabolic process (GO:0009071)3.98129914
15actin-mediated cell contraction (GO:0070252)3.94847643
16L-phenylalanine catabolic process (GO:0006559)3.88931900
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.88931900
18kynurenine metabolic process (GO:0070189)3.88231595
19cysteine metabolic process (GO:0006534)3.82824382
20glycine metabolic process (GO:0006544)3.78669526
21negative regulation of erythrocyte differentiation (GO:0045647)3.66205355
22glyoxylate metabolic process (GO:0046487)3.65917557
23hemidesmosome assembly (GO:0031581)3.63802989
24amino-acid betaine metabolic process (GO:0006577)3.60886992
25cellular glucuronidation (GO:0052695)3.54546431
26negative regulation of fibrinolysis (GO:0051918)3.53795506
27aromatic amino acid family catabolic process (GO:0009074)3.48583955
28sulfur amino acid catabolic process (GO:0000098)3.46361667
294-hydroxyproline metabolic process (GO:0019471)3.43746646
30myofibril assembly (GO:0030239)3.42711256
31protein localization to endosome (GO:0036010)3.42323033
32fatty acid beta-oxidation (GO:0006635)3.42017423
33cardiac myofibril assembly (GO:0055003)3.39829573
34homocysteine metabolic process (GO:0050667)3.39439727
35cell-substrate junction assembly (GO:0007044)3.37093961
36bundle of His cell to Purkinje myocyte communication (GO:0086069)3.36906199
37plasma membrane repair (GO:0001778)3.34422893
38regulation of cholesterol homeostasis (GO:2000188)3.32620694
39biotin metabolic process (GO:0006768)3.32411462
40negative regulation of fatty acid biosynthetic process (GO:0045717)3.29793722
41positive regulation of fatty acid beta-oxidation (GO:0032000)3.28860637
42aspartate family amino acid catabolic process (GO:0009068)3.27539544
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.26662113
44negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.25704276
45serine family amino acid metabolic process (GO:0009069)3.24354811
46tricarboxylic acid cycle (GO:0006099)3.23469182
47tryptophan catabolic process (GO:0006569)3.22209837
48indole-containing compound catabolic process (GO:0042436)3.22209837
49indolalkylamine catabolic process (GO:0046218)3.22209837
50peptidyl-glutamic acid carboxylation (GO:0017187)3.21190130
51protein carboxylation (GO:0018214)3.21190130
52triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.19766728
53carnitine metabolic process (GO:0009437)3.19632552
54carnitine transmembrane transport (GO:1902603)3.19425631
55cellular response to arsenic-containing substance (GO:0071243)3.17783615
56regulation of protein activation cascade (GO:2000257)3.15042565
57cardiac muscle cell development (GO:0055013)3.14708110
58fatty acid oxidation (GO:0019395)3.14529694
59bile acid biosynthetic process (GO:0006699)3.14039109
60regulation of sequestering of triglyceride (GO:0010889)3.10096226
61positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.09723759
62regulation of fibrinolysis (GO:0051917)3.07876555
63regulation of triglyceride catabolic process (GO:0010896)3.07582286
64acetyl-CoA metabolic process (GO:0006084)3.06663153
65tryptophan metabolic process (GO:0006568)3.05782077
66acylglycerol homeostasis (GO:0055090)3.05701099
67triglyceride homeostasis (GO:0070328)3.05701099
68regulation of necroptotic process (GO:0060544)3.05512263
69lipid oxidation (GO:0034440)3.04771786
70alpha-amino acid catabolic process (GO:1901606)3.04731822
71alpha-linolenic acid metabolic process (GO:0036109)3.03946442
72positive regulation of fatty acid oxidation (GO:0046321)3.03873784
73regulation of fatty acid oxidation (GO:0046320)3.02474888
74regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.02020810
75regulation of complement activation (GO:0030449)3.01664705
76fatty acid catabolic process (GO:0009062)3.00656399
77actin filament-based movement (GO:0030048)2.99913538
78carnitine transport (GO:0015879)2.99433878
79amino-acid betaine transport (GO:0015838)2.99433878
80branched-chain amino acid catabolic process (GO:0009083)2.98804201
81complement activation, alternative pathway (GO:0006957)2.97053988
82NADH metabolic process (GO:0006734)2.96525044
83glucuronate metabolic process (GO:0019585)2.96031225
84uronic acid metabolic process (GO:0006063)2.96031225
85cardiac cell development (GO:0055006)2.95718682
86fatty acid homeostasis (GO:0055089)2.95236454
87focal adhesion assembly (GO:0048041)2.94222749
88cell-substrate adherens junction assembly (GO:0007045)2.94222749
89oxaloacetate metabolic process (GO:0006107)2.91893544
90response to peptidoglycan (GO:0032494)2.91102156
91branched-chain amino acid metabolic process (GO:0009081)2.89509507
92regulation of fatty acid beta-oxidation (GO:0031998)2.88471009
93monocarboxylic acid catabolic process (GO:0072329)2.87464826
94negative regulation of necroptotic process (GO:0060546)2.87035589
95mannose metabolic process (GO:0006013)2.85311700
96cellular amino acid catabolic process (GO:0009063)2.82149706
97skin morphogenesis (GO:0043589)2.81917090
98tricarboxylic acid metabolic process (GO:0072350)2.81744779
99negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.80943162
100negative regulation of cell killing (GO:0031342)2.80943162
101negative regulation of fatty acid metabolic process (GO:0045922)2.80103647
102hypotonic response (GO:0006971)2.79412007
103protein hydroxylation (GO:0018126)2.78996861
104urea metabolic process (GO:0019627)2.77986255
105urea cycle (GO:0000050)2.77986255
106antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.77711687
107actomyosin structure organization (GO:0031032)2.77702700
108adherens junction assembly (GO:0034333)2.76518406
109ethanol oxidation (GO:0006069)2.75003596
110short-chain fatty acid metabolic process (GO:0046459)2.73861334
111regulation of necrotic cell death (GO:0010939)2.73450404
112skeletal muscle contraction (GO:0003009)2.73147753
113AMP metabolic process (GO:0046033)2.72815247
114serine family amino acid biosynthetic process (GO:0009070)2.72756805
115negative regulation of potassium ion transmembrane transport (GO:1901380)2.72746145
116carboxylic acid catabolic process (GO:0046395)2.72024285
117organic acid catabolic process (GO:0016054)2.72024285
118skeletal muscle adaptation (GO:0043501)2.71631720
119heart trabecula formation (GO:0060347)2.70585454
120activation of MAPKKK activity (GO:0000185)2.70444494
121regulation of fatty acid biosynthetic process (GO:0042304)2.70250299
122regulation of membrane protein ectodomain proteolysis (GO:0051043)2.69527488
123oxygen transport (GO:0015671)2.66720240
124negative regulation of fatty acid transport (GO:2000192)2.64694393
125response to muramyl dipeptide (GO:0032495)2.64376726
126stress fiber assembly (GO:0043149)2.61652241
127positive regulation of cholesterol efflux (GO:0010875)2.58565534
128positive regulation of myotube differentiation (GO:0010831)2.57306584
129antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.56964469
130response to laminar fluid shear stress (GO:0034616)2.54556548
131positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.53380568
132germinal center formation (GO:0002467)2.52743118
133positive regulation by symbiont of host defense response (GO:0052509)2.52357656
134modulation by symbiont of host defense response (GO:0052031)2.52357656
135modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.52357656
136modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.52357656
137positive regulation by organism of defense response of other organism involved in symbiotic interact2.52357656
138modulation by symbiont of host immune response (GO:0052553)2.52357656
139antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.52355525
140negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.52011859
141sarcoplasmic reticulum calcium ion transport (GO:0070296)2.50161614
142macrophage activation involved in immune response (GO:0002281)2.46402858
143negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.45370739
1443-UTR-mediated mRNA stabilization (GO:0070935)2.43608023
145antigen processing and presentation of endogenous antigen (GO:0019883)2.41630732
146detection of other organism (GO:0098543)2.41103588
147positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.40958648
148regulation of early endosome to late endosome transport (GO:2000641)2.40946962
149negative regulation of homotypic cell-cell adhesion (GO:0034111)2.40407875
150lipopolysaccharide-mediated signaling pathway (GO:0031663)2.39966106
151positive regulation of receptor recycling (GO:0001921)2.39728104
152regulation of water loss via skin (GO:0033561)2.37483089
153creatine metabolic process (GO:0006600)2.35066620
154gas transport (GO:0015669)2.34386644
155positive regulation of p38MAPK cascade (GO:1900745)2.33842791
156detection of molecule of bacterial origin (GO:0032490)2.33748980
157regulation of p38MAPK cascade (GO:1900744)2.33451449
158regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.33368565
159cellular response to epinephrine stimulus (GO:0071872)2.32493088
160regulation of T-helper 2 cell differentiation (GO:0045628)2.31258946
161regulation of leukocyte degranulation (GO:0043300)2.30979765
162barbed-end actin filament capping (GO:0051016)2.30941808
163modulation by symbiont of host cellular process (GO:0044068)2.30892796
164positive regulation of astrocyte differentiation (GO:0048711)2.30776007
165positive regulation of cellular amide metabolic process (GO:0034250)2.30579129
166macroautophagy (GO:0016236)2.30540572
167detection of bacterium (GO:0016045)2.28704364
168regulation of response to osmotic stress (GO:0047484)2.28467582
169negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.27856244
170apoptotic process involved in morphogenesis (GO:0060561)2.26049761
171negative regulation of viral release from host cell (GO:1902187)2.24525120
172negative regulation of necrotic cell death (GO:0060547)2.24255865
173negative regulation of cell size (GO:0045792)2.24240299
174embryonic process involved in female pregnancy (GO:0060136)2.20875876
175detection of external biotic stimulus (GO:0098581)2.20412484
176positive regulation of blood vessel endothelial cell migration (GO:0043536)2.18879272
177positive regulation of protein dephosphorylation (GO:0035307)2.17774550
178regulation of mast cell degranulation (GO:0043304)2.17754924
179positive regulation of gamma-delta T cell activation (GO:0046645)2.16611797
180regulation of transforming growth factor beta1 production (GO:0032908)2.14260833
181negative regulation of myotube differentiation (GO:0010832)2.13753913
182JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.12687715
183negative regulation of stress fiber assembly (GO:0051497)2.12563081
184keratinization (GO:0031424)2.11992519
185establishment of skin barrier (GO:0061436)2.11230020
186negative regulation of toll-like receptor signaling pathway (GO:0034122)2.09793309
187negative regulation of interleukin-6 production (GO:0032715)2.09658207
188epithelial cell differentiation involved in prostate gland development (GO:0060742)2.09549265
189negative regulation of type 2 immune response (GO:0002829)2.08865113
190negative regulation of interleukin-12 production (GO:0032695)2.08512607
191protein targeting to plasma membrane (GO:0072661)2.08499466
192negative regulation of cytokine production involved in immune response (GO:0002719)2.07316447
193desmosome organization (GO:0002934)2.06998561

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.61017145
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.86957248
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.70918491
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.46041016
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.71882877
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.10641614
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.04841798
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.66201905
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.63332317
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.62782099
11* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.58125286
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.57019704
13CLOCK_20551151_ChIP-Seq_293T_Human2.55808796
14VDR_21846776_ChIP-Seq_THP-1_Human2.42645568
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.40441816
16ZNF263_19887448_ChIP-Seq_K562_Human2.22068734
17* KDM2B_26808549_Chip-Seq_DND41_Human2.12489572
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.96827183
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91922522
20STAT3_1855785_ChIP-Seq_MESCs_Mouse1.88558992
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.82335314
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.82160779
23* KDM2B_26808549_Chip-Seq_K562_Human1.79697003
24VDR_24763502_ChIP-Seq_THP-1_Human1.75703982
25GATA1_19941826_ChIP-Seq_K562_Human1.74952326
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.72345629
27GATA1_22025678_ChIP-Seq_K562_Human1.71692382
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.66958783
29* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.65797572
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.64294193
31* MAF_26560356_Chip-Seq_TH1_Human1.63631320
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.63512385
33* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61428865
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59149013
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.57555635
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.57471609
37ATF3_27146783_Chip-Seq_COLON_Human1.57108167
38* KDM2B_26808549_Chip-Seq_JURKAT_Human1.55892230
39* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55369235
40TBX20_22080862_ChIP-Seq_HEART_Mouse1.53377224
41TBX20_22328084_ChIP-Seq_HEART_Mouse1.53377224
42* MYC_18555785_ChIP-Seq_MESCs_Mouse1.52413512
43* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52053873
44* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.51820777
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50934218
46STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.47567009
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.44991112
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43700105
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.43509131
50* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42186699
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41829919
52* SA1_27219007_Chip-Seq_ERYTHROID_Human1.39978438
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38657902
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38569056
55IRF8_22096565_ChIP-ChIP_GC-B_Human1.38398015
56* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38243710
57* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37731606
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37683885
59* MAF_26560356_Chip-Seq_TH2_Human1.37128561
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.36850612
61MYC_22102868_ChIP-Seq_BL_Human1.35780050
62* RACK7_27058665_Chip-Seq_MCF-7_Human1.30548858
63NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.29531102
64AR_21909140_ChIP-Seq_LNCAP_Human1.28085592
65* ELK3_25401928_ChIP-Seq_HUVEC_Human1.27617722
66STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26930785
67* UTX_26944678_Chip-Seq_JUKART_Human1.26347244
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.24618364
69* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.24189688
70TP53_22127205_ChIP-Seq_IMR90_Human1.22338633
71SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21944037
72* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21520429
73SPI1_23127762_ChIP-Seq_K562_Human1.21415000
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18952544
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18764039
76SMC4_20622854_ChIP-Seq_HELA_Human1.18357441
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18253242
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.17694947
79ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17055920
80* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16712947
81SCL_19346495_ChIP-Seq_HPC-7_Human1.16165316
82* CREB1_26743006_Chip-Seq_LNCaP_Human1.15785220
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13976141
84CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11905954
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11701226
86* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11371879
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.09774352
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09755068
89THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09407360
90TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.09234173
91SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08186010
92* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07661870
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07522157
94BCOR_27268052_Chip-Seq_Bcells_Human1.06152163
95GATA4_21415370_ChIP-Seq_HL-1_Mouse1.05714147
96SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05157754
97* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05129299
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04978867
99* TP63_22573176_ChIP-Seq_HFKS_Human1.04572810
100MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.04550953
101IRF8_27001747_Chip-Seq_BMDM_Mouse1.03452999
102ELF1_20517297_ChIP-Seq_JURKAT_Human1.03181645
103SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03093555
104* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02653906
105GATA2_19941826_ChIP-Seq_K562_Human1.02221404
106PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01808065
107SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01208283
108STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00174605
109EGR1_19374776_ChIP-ChIP_THP-1_Human0.99718268
110FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99104514
111FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98704703
112TRIM28_21343339_ChIP-Seq_HEK293_Human0.97977000
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96942415
114* GATA6_25053715_ChIP-Seq_YYC3_Human0.96611994
115* NCOR1_26117541_ChIP-Seq_K562_Human0.96295861
116MYC_19030024_ChIP-ChIP_MESCs_Mouse0.96287955
117CREB1_15753290_ChIP-ChIP_HEK293T_Human0.95961086
118* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95239221
119* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.94698706
120TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94466483
121* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94193971
122NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92775089
123DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91696158
124* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91524965
125CTCF_21964334_Chip-Seq_Bcells_Human0.91443800
126* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90670524
127* UBF1/2_26484160_Chip-Seq_HMECs_Human0.89888273
128* LXR_22292898_ChIP-Seq_THP-1_Human0.89403836
129GATA4_25053715_ChIP-Seq_YYC3_Human0.89080731
130* CHD1_26751641_Chip-Seq_LNCaP_Human0.88993299
131SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88568521
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87202562
133* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87011426
134MYC_19079543_ChIP-ChIP_MESCs_Mouse0.86508603
135* TCF7_22412390_ChIP-Seq_EML_Mouse0.86449216
136ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85474744
137* FOXO3_23340844_ChIP-Seq_DLD1_Human0.85056520
138* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84760915
139GATA3_24758297_ChIP-Seq_MCF-7_Human0.83775891
140RXRA_24833708_ChIP-Seq_LIVER_Mouse0.83198028
141* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82925899
142FOXA2_19822575_ChIP-Seq_HepG2_Human0.82904412
143* HNF4A_19822575_ChIP-Seq_HepG2_Human0.82343932
144SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82195295
145SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82195295
146NANOG_18555785_ChIP-Seq_MESCs_Mouse0.79932923
147* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.79754765
148RBPJ_22232070_ChIP-Seq_NCS_Mouse0.79101918
149* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.78646451
150* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.78014280
151EP300_21415370_ChIP-Seq_HL-1_Mouse0.77815284
152P68_20966046_ChIP-Seq_HELA_Human0.77361070
153* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.77194398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.78936077
2MP0003646_muscle_fatigue3.74794504
3MP0002837_dystrophic_cardiac_calcinosis3.38003020
4MP0005085_abnormal_gallbladder_physiolo3.22162184
5MP0005365_abnormal_bile_salt3.20537867
6MP0003806_abnormal_nucleotide_metabolis3.00484109
7MP0005360_urolithiasis2.92645320
8MP0004084_abnormal_cardiac_muscle2.87185549
9MP0000749_muscle_degeneration2.80545931
10MP0000751_myopathy2.58143850
11MP0003705_abnormal_hypodermis_morpholog2.43804404
12MP0004036_abnormal_muscle_relaxation2.43200236
13MP0003436_decreased_susceptibility_to2.42058777
14MP0003303_peritoneal_inflammation2.38703532
15MP0009840_abnormal_foam_cell2.32210010
16MP0004510_myositis2.27324894
17MP0005330_cardiomyopathy2.22508064
18MP0000750_abnormal_muscle_regeneration2.14827761
19MP0004087_abnormal_muscle_fiber2.09698891
20MP0008875_abnormal_xenobiotic_pharmacok2.07173667
21MP0002269_muscular_atrophy2.04447708
22MP0008260_abnormal_autophagy2.01441385
23MP0003453_abnormal_keratinocyte_physiol2.01112644
24MP0005083_abnormal_biliary_tract1.89466587
25MP0003252_abnormal_bile_duct1.83605544
26MP0004947_skin_inflammation1.81311266
27MP0004130_abnormal_muscle_cell1.80968247
28MP0000747_muscle_weakness1.76885174
29MP0002106_abnormal_muscle_physiology1.72191895
30MP0010329_abnormal_lipoprotein_level1.67587602
31MP0005076_abnormal_cell_differentiation1.65334860
32MP0005058_abnormal_lysosome_morphology1.64342858
33MP0010630_abnormal_cardiac_muscle1.64114633
34MP0003091_abnormal_cell_migration1.62580645
35MP0003300_gastrointestinal_ulcer1.62065212
36MP0005620_abnormal_muscle_contractility1.56420002
37MP0000759_abnormal_skeletal_muscle1.54862012
38MP0004145_abnormal_muscle_electrophysio1.53525913
39MP0004858_abnormal_nervous_system1.50440599
40MP0004381_abnormal_hair_follicle1.49611262
41MP0001958_emphysema1.47556813
42MP0004185_abnormal_adipocyte_glucose1.47013559
43MP0003724_increased_susceptibility_to1.46640679
44MP0005670_abnormal_white_adipose1.46622498
45MP0003195_calcinosis1.46098540
46MP0005666_abnormal_adipose_tissue1.44215096
47MP0005332_abnormal_amino_acid1.43377944
48MP0004215_abnormal_myocardial_fiber1.40573374
49MP0009278_abnormal_bone_marrow1.40568853
50MP0002972_abnormal_cardiac_muscle1.39930807
51MP0006036_abnormal_mitochondrial_physio1.39827573
52MP0005369_muscle_phenotype1.39802310
53MP0003221_abnormal_cardiomyocyte_apopto1.39178310
54MP0005319_abnormal_enzyme/_coenzyme1.38799348
55MP0003045_fibrosis1.37568792
56MP0003075_altered_response_to1.37314282
57MP0000609_abnormal_liver_physiology1.36719939
58MP0010352_gastrointestinal_tract_polyps1.36117899
59MP0001533_abnormal_skeleton_physiology1.35163713
60MP0003191_abnormal_cellular_cholesterol1.34835787
61MP0006138_congestive_heart_failure1.34139836
62MP0003172_abnormal_lysosome_physiology1.33525183
63MP0001666_abnormal_nutrient_absorption1.31064431
64MP0000685_abnormal_immune_system1.30885792
65MP0003566_abnormal_cell_adhesion1.28677856
66MP0002419_abnormal_innate_immunity1.27680942
67MP0001544_abnormal_cardiovascular_syste1.26627065
68MP0005385_cardiovascular_system_phenoty1.26627065
69MP0002877_abnormal_melanocyte_morpholog1.24608659
70MP0005451_abnormal_body_composition1.22948661
71MP0002998_abnormal_bone_remodeling1.22714103
72MP0004233_abnormal_muscle_weight1.19595986
73MP0000858_altered_metastatic_potential1.19448960
74MP0002118_abnormal_lipid_homeostasis1.17116993
75MP0008775_abnormal_heart_ventricle1.16221170
76MP0005025_abnormal_response_to1.14326586
77MP0000733_abnormal_muscle_development1.13333549
78MP0009785_altered_susceptibility_to1.13299383
79MP0010368_abnormal_lymphatic_system1.13135419
80MP0000003_abnormal_adipose_tissue1.12417486
81MP0003329_amyloid_beta_deposits1.09221494
82MP0009333_abnormal_splenocyte_physiolog1.08452670
83MP0005000_abnormal_immune_tolerance1.06189382
84MP0002234_abnormal_pharynx_morphology1.05751071
85MP0005275_abnormal_skin_tensile1.05416370
86MP0003656_abnormal_erythrocyte_physiolo1.05335137
87MP0005409_darkened_coat_color1.04724183
88MP0005164_abnormal_response_to1.04394319
89MP0005387_immune_system_phenotype1.02416671
90MP0001790_abnormal_immune_system1.02416671
91MP0000579_abnormal_nail_morphology1.00886010
92MP0003763_abnormal_thymus_physiology1.00871795
93MP0004272_abnormal_basement_membrane1.00343663
94MP0005397_hematopoietic_system_phenotyp0.99862509
95MP0001545_abnormal_hematopoietic_system0.99862509
96MP0010234_abnormal_vibrissa_follicle0.99860082
97MP0003186_abnormal_redox_activity0.95220898
98MP0004019_abnormal_vitamin_homeostasis0.94966145
99MP0000013_abnormal_adipose_tissue0.94040689
100MP0005375_adipose_tissue_phenotype0.91786217
101MP0002127_abnormal_cardiovascular_syste0.91021011
102MP0001851_eye_inflammation0.90799851
103MP0000604_amyloidosis0.90171852
104MP0002405_respiratory_system_inflammati0.90072768
105MP0001216_abnormal_epidermal_layer0.90050468
106MP0004484_altered_response_of0.89990256
107MP0002060_abnormal_skin_morphology0.89362160
108MP0009643_abnormal_urine_homeostasis0.89152345
109MP0005501_abnormal_skin_physiology0.88930658
110MP0008438_abnormal_cutaneous_collagen0.87714509
111MP0005266_abnormal_metabolism0.86357015
112MP0002332_abnormal_exercise_endurance0.86167566
113MP0002971_abnormal_brown_adipose0.86084657
114MP0003567_abnormal_fetal_cardiomyocyte0.85975101
115MP0002148_abnormal_hypersensitivity_rea0.85803838
116MP0005023_abnormal_wound_healing0.85691532
117MP0005390_skeleton_phenotype0.85458360
118MP0006082_CNS_inflammation0.83173216
119MP0005165_increased_susceptibility_to0.82764889
120MP0009931_abnormal_skin_appearance0.81947911
121MP0000598_abnormal_liver_morphology0.81784283
122MP0000266_abnormal_heart_morphology0.81355836
123MP0003828_pulmonary_edema0.80847525
124MP0003448_altered_tumor_morphology0.80750791
125MP0009053_abnormal_anal_canal0.80417524
126MP0002723_abnormal_immune_serum0.80031755
127MP0003984_embryonic_growth_retardation0.79538274
128MP0002088_abnormal_embryonic_growth/wei0.79090746
129MP0003279_aneurysm0.78612540
130MP0002108_abnormal_muscle_morphology0.77966531
131MP0009672_abnormal_birth_weight0.77698754
132MP0003137_abnormal_impulse_conducting0.77262168
133MP0000678_abnormal_parathyroid_gland0.75582788
134MP0002138_abnormal_hepatobiliary_system0.74610002
135MP0000343_altered_response_to0.70633827
136MP0002078_abnormal_glucose_homeostasis0.69860037
137MP0005220_abnormal_exocrine_pancreas0.68868413
138MP0003950_abnormal_plasma_membrane0.68583122
139MP0002796_impaired_skin_barrier0.67369852
140MP0003868_abnormal_feces_composition0.67317798
141MP0001764_abnormal_homeostasis0.67134284
142MP0001672_abnormal_embryogenesis/_devel0.65623764
143MP0005380_embryogenesis_phenotype0.65623764
144MP0002128_abnormal_blood_circulation0.62750938
145MP0006035_abnormal_mitochondrial_morpho0.62216300
146MP0005334_abnormal_fat_pad0.61493422
147MP0004197_abnormal_fetal_growth/weight/0.61371538
148MP0001243_abnormal_dermal_layer0.59272099
149MP0001849_ear_inflammation0.58601275
150MP0000767_abnormal_smooth_muscle0.57298096
151MP0004085_abnormal_heartbeat0.56722516
152MP0010030_abnormal_orbit_morphology0.55079177

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)4.79291467
2Exercise-induced myalgia (HP:0003738)4.70347879
3Muscle fiber splitting (HP:0003555)4.68615515
4Myoglobinuria (HP:0002913)4.28563506
5Increased connective tissue (HP:0009025)4.19276718
6Muscle fiber inclusion bodies (HP:0100299)4.08200558
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.07421292
8Hyporeflexia of lower limbs (HP:0002600)4.02766532
9Calf muscle hypertrophy (HP:0008981)3.97632468
10Muscle hypertrophy of the lower extremities (HP:0008968)3.85737658
11Right ventricular cardiomyopathy (HP:0011663)3.83879106
12Sudden death (HP:0001699)3.76166545
13Ventricular tachycardia (HP:0004756)3.68586946
14Rhabdomyolysis (HP:0003201)3.67903820
15Increased variability in muscle fiber diameter (HP:0003557)3.58444153
16Nemaline bodies (HP:0003798)3.47892205
17Type 1 muscle fiber predominance (HP:0003803)3.45958654
18Difficulty climbing stairs (HP:0003551)3.36286795
19Difficulty running (HP:0009046)3.33306488
20Deep venous thrombosis (HP:0002625)3.28801215
21Hypoglycemic coma (HP:0001325)3.27285850
22Hyperglycinuria (HP:0003108)3.24566586
23Hyperglycinemia (HP:0002154)3.22190541
24Abnormality of the calf musculature (HP:0001430)3.19949795
25EMG: myopathic abnormalities (HP:0003458)3.16231728
26Xanthomatosis (HP:0000991)3.13846856
27Abnormality of aromatic amino acid family metabolism (HP:0004338)3.11583350
28Subaortic stenosis (HP:0001682)3.09479114
29Abnormality of the left ventricular outflow tract (HP:0011103)3.09479114
30Distal lower limb muscle weakness (HP:0009053)3.09433040
31Intrahepatic cholestasis (HP:0001406)3.07047619
32Abnormality of monocarboxylic acid metabolism (HP:0010996)3.05140818
33Hypoalphalipoproteinemia (HP:0003233)3.01715418
34Centrally nucleated skeletal muscle fibers (HP:0003687)2.95344356
35Asymmetric septal hypertrophy (HP:0001670)2.89976607
36Abnormality of glycine metabolism (HP:0010895)2.89461511
37Abnormality of serine family amino acid metabolism (HP:0010894)2.89461511
38Vertebral compression fractures (HP:0002953)2.89420226
39Hyperammonemia (HP:0001987)2.88561855
40Ketosis (HP:0001946)2.87525285
41Spinal rigidity (HP:0003306)2.81366702
42Lipoatrophy (HP:0100578)2.73639477
43Abnormality of fatty-acid metabolism (HP:0004359)2.72847235
44Hyperglycemia (HP:0003074)2.71254765
45Myopathic facies (HP:0002058)2.70361930
46Gout (HP:0001997)2.69266060
47Hypolipoproteinemia (HP:0010981)2.67947390
48Distal arthrogryposis (HP:0005684)2.67889896
49Abnormality of nail color (HP:0100643)2.67660157
50Ulnar deviation of the wrist (HP:0003049)2.67256672
51Hypoplastic ischia (HP:0003175)2.62673506
52Areflexia of lower limbs (HP:0002522)2.61942801
53Atrioventricular block (HP:0001678)2.59441973
54Ketoacidosis (HP:0001993)2.56240384
55Hypobetalipoproteinemia (HP:0003563)2.53477164
56Obstructive sleep apnea (HP:0002870)2.49222951
57Eczematoid dermatitis (HP:0000976)2.48787518
58Muscle stiffness (HP:0003552)2.48046390
59Palpitations (HP:0001962)2.47660380
60Slender build (HP:0001533)2.45186674
61Premature rupture of membranes (HP:0001788)2.40635930
62Dilated cardiomyopathy (HP:0001644)2.39863243
63Increased IgE level (HP:0003212)2.39820560
64Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.37655677
65Hyperlipoproteinemia (HP:0010980)2.36971081
66Abnormality of the ischium (HP:0003174)2.34915237
67Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.32710413
68Bundle branch block (HP:0011710)2.32163480
69Abnormality of the intrinsic pathway (HP:0010989)2.31000052
70Limb-girdle muscle atrophy (HP:0003797)2.28835843
71Thick nail (HP:0001805)2.28330609
72Cerebral aneurysm (HP:0004944)2.28161002
73Abnormality of liposaccharide metabolism (HP:0010968)2.27375254
74Abnormality of glycosphingolipid metabolism (HP:0004343)2.27375254
75Abnormality of glycolipid metabolism (HP:0010969)2.27375254
76Abnormal cartilage morphology (HP:0002763)2.27260064
77Dicarboxylic aciduria (HP:0003215)2.26941414
78Abnormality of dicarboxylic acid metabolism (HP:0010995)2.26941414
79Abnormal atrioventricular conduction (HP:0005150)2.24611318
80Round ear (HP:0100830)2.23690290
81Hyperinsulinemic hypoglycemia (HP:0000825)2.22566069
82Atrial fibrillation (HP:0005110)2.21668471
83Atrophic scars (HP:0001075)2.19724355
84Myotonia (HP:0002486)2.17348341
85Heart block (HP:0012722)2.15530590
86Complement deficiency (HP:0004431)2.13446849
87Myositis (HP:0100614)2.13165220
88Aortic aneurysm (HP:0004942)2.12751201
89Neck muscle weakness (HP:0000467)2.12099602
90Abnormality of serum amino acid levels (HP:0003112)2.12033247
91Fragile skin (HP:0001030)2.10071034
92Orchitis (HP:0100796)2.09570802
93Progressive muscle weakness (HP:0003323)2.08927723
94Ventricular arrhythmia (HP:0004308)2.08592930
95Mildly elevated creatine phosphokinase (HP:0008180)2.07551748
96Milia (HP:0001056)2.07128264
97Achilles tendon contracture (HP:0001771)2.06570508
98Prolonged partial thromboplastin time (HP:0003645)2.06007740
99Abnormality of sulfur amino acid metabolism (HP:0004339)2.04769265
100Cholelithiasis (HP:0001081)2.04289799
101Broad face (HP:0000283)2.03901011
102Stridor (HP:0010307)2.03034935
103Bulbar palsy (HP:0001283)2.02890443
104Multiple enchondromatosis (HP:0005701)2.01043885
105Late onset (HP:0003584)2.00374915
106Generalized amyotrophy (HP:0003700)1.99543370
107Primary atrial arrhythmia (HP:0001692)1.98547030
108Flat acetabular roof (HP:0003180)1.97818011
109Easy fatigability (HP:0003388)1.97593417
110Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97027940
111Malignant hyperthermia (HP:0002047)1.96345305
112Abnormality of purine metabolism (HP:0004352)1.96344225
113Myocardial infarction (HP:0001658)1.96232637
114Abnormality of skeletal muscle fiber size (HP:0012084)1.95776688
115Lower limb amyotrophy (HP:0007210)1.95553802
116Abnormality of macrophages (HP:0004311)1.94298026
117Protrusio acetabuli (HP:0003179)1.94143028
118Dilatation of the ascending aorta (HP:0005111)1.92109503
119Supraventricular tachycardia (HP:0004755)1.91800926
120Abnormal gallbladder morphology (HP:0012437)1.90672839
121Hypertriglyceridemia (HP:0002155)1.90289810
122Abnormality of the Achilles tendon (HP:0005109)1.89936567
123Skin nodule (HP:0200036)1.89858829
124Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.89729737
125Hyperuricemia (HP:0002149)1.89640943
126Increased purine levels (HP:0004368)1.89640943
127Supraventricular arrhythmia (HP:0005115)1.89274798
128Ulnar bowing (HP:0003031)1.88649773
129Abnormality of the common coagulation pathway (HP:0010990)1.88627640
130Increased cerebral lipofuscin (HP:0011813)1.86746265
131Cupped ribs (HP:0000887)1.86193149
132Axonal loss (HP:0003447)1.86138432
133EMG: neuropathic changes (HP:0003445)1.85844788
134Absent phalangeal crease (HP:0006109)1.84719919
135Aneurysm (HP:0002617)1.83930858
136Distal lower limb amyotrophy (HP:0008944)1.83441252
137Testicular atrophy (HP:0000029)1.82291204
138Polycythemia (HP:0001901)1.81759780
139Scapular winging (HP:0003691)1.79016236
140Diaphragmatic weakness (HP:0009113)1.76573577
141Gastrointestinal infarctions (HP:0005244)1.76412428
142Increased serum ferritin (HP:0003281)1.75936723
143Frequent falls (HP:0002359)1.73766964
144Natal tooth (HP:0000695)1.72498426
145Cerebral inclusion bodies (HP:0100314)1.72061879
146Cervical subluxation (HP:0003308)1.71900053
147Generalized muscle weakness (HP:0003324)1.71137533
148Foot dorsiflexor weakness (HP:0009027)1.70646476
149Dysostosis multiplex (HP:0000943)1.68983467
150Increased neuronal autofluorescent lipopigment (HP:0002074)1.66240288
151Osteolytic defects of the hand bones (HP:0009699)1.66197437
152Osteolytic defects of the phalanges of the hand (HP:0009771)1.66197437
153Abnormal blistering of the skin (HP:0008066)1.65902223
154Reduced subcutaneous adipose tissue (HP:0003758)1.65529787
155Segmental peripheral demyelination/remyelination (HP:0003481)1.65388088
156Ankle contracture (HP:0006466)1.65367563
157Elbow flexion contracture (HP:0002987)1.63778008
158Mitral regurgitation (HP:0001653)1.63096097
159Mitral stenosis (HP:0001718)1.61584372
160Fatigue (HP:0012378)1.61456573
161Persistence of primary teeth (HP:0006335)1.60247622
162Ragged-red muscle fibers (HP:0003200)1.59006619
163Follicular hyperkeratosis (HP:0007502)1.58660184
164Muscular dystrophy (HP:0003560)1.58632134
165Neurofibrillary tangles (HP:0002185)1.58611797

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.38647175
2BCKDK3.65002769
3OBSCN3.46808219
4TRIB33.39485615
5PKN23.15530035
6MAP3K32.85080752
7PRPF4B2.79569101
8LATS12.48869283
9ERN12.44555203
10MAP2K32.31633260
11SIK12.25024334
12PDK42.22312893
13PDK32.22312893
14STK38L2.14294340
15PHKG11.91433846
16PHKG21.91433846
17ICK1.90375467
18NEK11.88617936
19SMG11.86175996
20FLT31.83575247
21EPHA21.81974667
22PDK21.71143985
23TAOK21.68520905
24FGFR41.67265035
25EEF2K1.52514872
26KSR21.52476300
27MAP3K11.50651902
28MAPKAPK31.44504561
29TBK11.44253156
30PIK3CG1.44017240
31PRKD21.41465285
32STK241.40422097
33MAP3K61.40275647
34MAP3K131.35229146
35ZAP701.32633348
36IRAK41.29521809
37NEK91.26003079
38MYLK1.22942768
39PINK11.21743346
40MARK21.20604201
41DMPK1.16283135
42LATS21.16124973
43ZAK1.15834080
44RIPK11.13869337
45STK31.10911227
46STK381.09470314
47MAP3K51.07878438
48MAP3K101.06986383
49MOS1.06805248
50TRPM71.01820748
51PIK3CA1.00953645
52AKT31.00311759
53INSRR0.99295552
54CDK120.99146239
55MAP3K70.98567804
56MAP4K10.97909009
57NME10.97532675
58MTOR0.94289186
59MAPK110.93840427
60CSK0.93269712
61BLK0.92983227
62RPS6KA40.92262134
63PTK60.91711272
64CDC42BPA0.90362491
65TAOK10.89073140
66RIPK40.88827822
67HIPK20.87438759
68MAP3K110.87346442
69PDGFRA0.87259613
70PRKAA20.85315008
71PDPK10.84110613
72CAMK1D0.83129413
73BMX0.82026412
74RPS6KB20.80718914
75MAPK120.80034197
76SGK30.78707784
77PRKAA10.76854435
78MAP2K60.76744244
79NME20.75626816
80MAP3K20.74628271
81RPS6KA20.74563466
82IRAK20.73530623
83ARAF0.72346736
84STK100.72324743
85PAK40.72294295
86RAF10.71833371
87MAP3K140.71335641
88IKBKB0.70625234
89HCK0.70595559
90BRSK20.68404230
91IKBKE0.67163607
92PIM20.66774724
93JAK30.66028123
94CDK40.65470972
95EIF2AK10.65167062
96TGFBR20.65137160
97IRAK30.62111972
98TNK20.61753654
99EPHB10.61248834
100MAPK70.61198867
101WNK10.58320283
102CHUK0.57903301
103GRK60.57565709
104MAPK40.56740108
105TYK20.54950556
106MAP2K10.54543141
107MAPK150.54319274
108LRRK20.54043856
109MAP3K80.53625681
110CDK60.53171188
111IRAK10.52886588
112KDR0.52711786
113AKT20.52582717
114PTK20.51873425
115PDGFRB0.50473142
116WEE10.49799151
117PDK10.49791691
118PAK20.49690016
119TIE10.48796403
120JAK10.47952141
121FES0.47458017
122LMTK20.47341806
123DDR20.46884877
124JAK20.46612196
125STK40.46136628
126TAOK30.46013603
127ILK0.44565638
128FGFR10.42332142
129PTK2B0.41689393
130CAMK40.41411631
131DYRK1B0.40983180
132ABL20.38387668
133PAK30.38305537
134EPHA30.36667384
135NEK20.36589033
136DYRK30.36315593
137MST1R0.36011061
138MAP2K20.35706953
139PRKD10.35431974
140PIM10.34416368
141MET0.34145377
142ERBB40.33231595
143PASK0.30784954
144NLK0.30722861
145GSK3A0.30655624
146RPS6KL10.30630558
147RPS6KC10.30630558
148RPS6KA10.30112639
149CDK70.30057535
150AURKB0.29646498
151RPS6KA60.28207690

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.43879052
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.05421314
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.94888529
4Fatty acid degradation_Homo sapiens_hsa000712.70083369
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.66590175
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.60937474
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.57380070
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.54303595
9Propanoate metabolism_Homo sapiens_hsa006402.46295800
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.35567352
11Arginine biosynthesis_Homo sapiens_hsa002202.33761158
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.14884315
13Tryptophan metabolism_Homo sapiens_hsa003802.10237985
14Carbon metabolism_Homo sapiens_hsa012002.05000149
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.01059077
16Osteoclast differentiation_Homo sapiens_hsa043801.92069611
17Selenocompound metabolism_Homo sapiens_hsa004501.89849036
18Acute myeloid leukemia_Homo sapiens_hsa052211.89661999
19Biosynthesis of amino acids_Homo sapiens_hsa012301.88957089
20Fatty acid metabolism_Homo sapiens_hsa012121.82453796
21Other glycan degradation_Homo sapiens_hsa005111.81735555
22Starch and sucrose metabolism_Homo sapiens_hsa005001.81423854
23Nitrogen metabolism_Homo sapiens_hsa009101.73548219
24Malaria_Homo sapiens_hsa051441.71370921
25Chronic myeloid leukemia_Homo sapiens_hsa052201.66478744
26PPAR signaling pathway_Homo sapiens_hsa033201.63000410
27Complement and coagulation cascades_Homo sapiens_hsa046101.61888910
28TNF signaling pathway_Homo sapiens_hsa046681.61691746
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.57686648
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.57374163
31Butanoate metabolism_Homo sapiens_hsa006501.57126063
32Vitamin B6 metabolism_Homo sapiens_hsa007501.56255137
33VEGF signaling pathway_Homo sapiens_hsa043701.55389672
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.55189570
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.54929600
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.53051593
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52003616
38Folate biosynthesis_Homo sapiens_hsa007901.49782673
39beta-Alanine metabolism_Homo sapiens_hsa004101.47848985
40Pyruvate metabolism_Homo sapiens_hsa006201.45336953
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.43878422
42Peroxisome_Homo sapiens_hsa041461.39216729
43Non-small cell lung cancer_Homo sapiens_hsa052231.37751457
44Sulfur relay system_Homo sapiens_hsa041221.35146414
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.35110669
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35053752
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.33706305
48Phenylalanine metabolism_Homo sapiens_hsa003601.33264952
49Chemical carcinogenesis_Homo sapiens_hsa052041.32036938
50Toxoplasmosis_Homo sapiens_hsa051451.30585309
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.30028273
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.28456493
53Caffeine metabolism_Homo sapiens_hsa002321.27132041
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.27066564
55Arginine and proline metabolism_Homo sapiens_hsa003301.26889239
56Retinol metabolism_Homo sapiens_hsa008301.24148627
57Glycosaminoglycan degradation_Homo sapiens_hsa005311.20983439
58Pancreatic cancer_Homo sapiens_hsa052121.20981974
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20600096
60B cell receptor signaling pathway_Homo sapiens_hsa046621.20490012
61GnRH signaling pathway_Homo sapiens_hsa049121.20328388
62Neurotrophin signaling pathway_Homo sapiens_hsa047221.20139264
63Renal cell carcinoma_Homo sapiens_hsa052111.20070084
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18703788
65Notch signaling pathway_Homo sapiens_hsa043301.18368121
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17911044
67Leishmaniasis_Homo sapiens_hsa051401.17397871
68Amoebiasis_Homo sapiens_hsa051461.16821371
69NOD-like receptor signaling pathway_Homo sapiens_hsa046211.15068841
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14174710
71One carbon pool by folate_Homo sapiens_hsa006701.12965975
72Hepatitis C_Homo sapiens_hsa051601.12707282
73Lysine degradation_Homo sapiens_hsa003101.12578176
74Tuberculosis_Homo sapiens_hsa051521.12048522
75Prion diseases_Homo sapiens_hsa050201.09086510
76NF-kappa B signaling pathway_Homo sapiens_hsa040641.06437743
77Pentose phosphate pathway_Homo sapiens_hsa000301.06288967
78Jak-STAT signaling pathway_Homo sapiens_hsa046301.05824283
79Dilated cardiomyopathy_Homo sapiens_hsa054141.05800534
80Insulin resistance_Homo sapiens_hsa049311.05697517
81Lysosome_Homo sapiens_hsa041421.03485031
82Steroid hormone biosynthesis_Homo sapiens_hsa001401.01834664
83Influenza A_Homo sapiens_hsa051641.00800831
84Fructose and mannose metabolism_Homo sapiens_hsa000510.99313442
85Apoptosis_Homo sapiens_hsa042100.98976805
86Hepatitis B_Homo sapiens_hsa051610.96967100
87ErbB signaling pathway_Homo sapiens_hsa040120.96338946
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.95584069
89Tyrosine metabolism_Homo sapiens_hsa003500.95354427
90Measles_Homo sapiens_hsa051620.94962687
91T cell receptor signaling pathway_Homo sapiens_hsa046600.94799227
92Proteoglycans in cancer_Homo sapiens_hsa052050.93308600
93Fat digestion and absorption_Homo sapiens_hsa049750.92878787
94Prolactin signaling pathway_Homo sapiens_hsa049170.92280169
95Endometrial cancer_Homo sapiens_hsa052130.90358331
96Glioma_Homo sapiens_hsa052140.90173567
97Galactose metabolism_Homo sapiens_hsa000520.89950401
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.88992118
99Pertussis_Homo sapiens_hsa051330.88170021
100Sulfur metabolism_Homo sapiens_hsa009200.87889681
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87223944
102MAPK signaling pathway_Homo sapiens_hsa040100.85876570
103Histidine metabolism_Homo sapiens_hsa003400.83739789
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83405313
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.83364660
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82470193
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.81650105
108Salmonella infection_Homo sapiens_hsa051320.79962083
109Legionellosis_Homo sapiens_hsa051340.79130368
110Inositol phosphate metabolism_Homo sapiens_hsa005620.78058627
111African trypanosomiasis_Homo sapiens_hsa051430.76423450
112Fatty acid elongation_Homo sapiens_hsa000620.75866110
113Endocytosis_Homo sapiens_hsa041440.74317794
114Bile secretion_Homo sapiens_hsa049760.74157736
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72631729
116Shigellosis_Homo sapiens_hsa051310.72523302
117Estrogen signaling pathway_Homo sapiens_hsa049150.72030118
118Chemokine signaling pathway_Homo sapiens_hsa040620.71275060
119Platelet activation_Homo sapiens_hsa046110.70943853
120Dorso-ventral axis formation_Homo sapiens_hsa043200.70656456
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70477738
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70343927
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.70276750
124Prostate cancer_Homo sapiens_hsa052150.69637610
125Glucagon signaling pathway_Homo sapiens_hsa049220.69553069
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68967562
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.68600012
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67910875
129Type II diabetes mellitus_Homo sapiens_hsa049300.67261774
130Staphylococcus aureus infection_Homo sapiens_hsa051500.66990368
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66947217
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66782272
133AMPK signaling pathway_Homo sapiens_hsa041520.65346612
134Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64606967
135Glutathione metabolism_Homo sapiens_hsa004800.63611681
136Choline metabolism in cancer_Homo sapiens_hsa052310.62396442
137MicroRNAs in cancer_Homo sapiens_hsa052060.61629952
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61009468
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60343967
140ABC transporters_Homo sapiens_hsa020100.59733487
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59132011
142cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58477036
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56382333
144Insulin signaling pathway_Homo sapiens_hsa049100.55291737
145HTLV-I infection_Homo sapiens_hsa051660.54712004
146Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54288187
147Vascular smooth muscle contraction_Homo sapiens_hsa042700.53522900
148Cardiac muscle contraction_Homo sapiens_hsa042600.53280876
149Vitamin digestion and absorption_Homo sapiens_hsa049770.52350419
150Glycerolipid metabolism_Homo sapiens_hsa005610.50349204
151ECM-receptor interaction_Homo sapiens_hsa045120.49492003
152Metabolic pathways_Homo sapiens_hsa011000.46915159
153Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46537349
154Central carbon metabolism in cancer_Homo sapiens_hsa052300.45602495
155Circadian rhythm_Homo sapiens_hsa047100.39880707
156Fatty acid biosynthesis_Homo sapiens_hsa000610.35464893
157Focal adhesion_Homo sapiens_hsa045100.33578309
158Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33285642
159Viral myocarditis_Homo sapiens_hsa054160.31925816
160Adherens junction_Homo sapiens_hsa045200.30894502
161Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30055193
162Thyroid cancer_Homo sapiens_hsa052160.29487442
163HIF-1 signaling pathway_Homo sapiens_hsa040660.28697411
164Small cell lung cancer_Homo sapiens_hsa052220.27939632
165Bladder cancer_Homo sapiens_hsa052190.26643498
166Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26375467
167p53 signaling pathway_Homo sapiens_hsa041150.26231991
168RNA transport_Homo sapiens_hsa030130.25582079
169Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24841103
170Regulation of autophagy_Homo sapiens_hsa041400.22475450
171Protein digestion and absorption_Homo sapiens_hsa049740.20925740
172mTOR signaling pathway_Homo sapiens_hsa041500.20560443
173FoxO signaling pathway_Homo sapiens_hsa040680.19953478
174Glycerophospholipid metabolism_Homo sapiens_hsa005640.14471770

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