KLHL22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.42489090
2synaptic vesicle docking involved in exocytosis (GO:0016081)5.00505589
3vocalization behavior (GO:0071625)4.99646498
4synaptic vesicle exocytosis (GO:0016079)4.92578728
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.67285678
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.62532657
7neuron cell-cell adhesion (GO:0007158)4.54470132
8synaptic vesicle maturation (GO:0016188)4.42915483
9regulation of synaptic vesicle exocytosis (GO:2000300)4.35554049
10glutamate secretion (GO:0014047)4.34165057
11locomotory exploration behavior (GO:0035641)4.30668064
12regulation of glutamate receptor signaling pathway (GO:1900449)4.27661789
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.19482759
14neurotransmitter secretion (GO:0007269)4.10526285
15regulation of ARF protein signal transduction (GO:0032012)4.06894084
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.93156972
17proline transport (GO:0015824)3.91033327
18postsynaptic membrane organization (GO:0001941)3.90944648
19regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.90244871
20regulation of synapse structural plasticity (GO:0051823)3.89306050
21regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.85303723
22exploration behavior (GO:0035640)3.85233883
23regulation of synaptic vesicle transport (GO:1902803)3.81884562
24protein localization to synapse (GO:0035418)3.75893952
25neurotransmitter-gated ion channel clustering (GO:0072578)3.68404941
26negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.68362976
27positive regulation of synapse maturation (GO:0090129)3.68125774
28regulation of long-term neuronal synaptic plasticity (GO:0048169)3.67227510
29regulation of neuronal synaptic plasticity (GO:0048168)3.64273757
30ionotropic glutamate receptor signaling pathway (GO:0035235)3.55815400
31synaptic transmission, glutamatergic (GO:0035249)3.49518742
32neuron-neuron synaptic transmission (GO:0007270)3.40504050
33mannose metabolic process (GO:0006013)3.39616954
34long-term synaptic potentiation (GO:0060291)3.37789483
35response to pheromone (GO:0019236)3.33979774
36neuron recognition (GO:0008038)3.33490071
37negative regulation of norepinephrine secretion (GO:0010700)3.33343837
38neuronal action potential propagation (GO:0019227)3.33075591
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.30145647
40positive regulation of membrane potential (GO:0045838)3.29226881
41regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.28033818
42axonal fasciculation (GO:0007413)3.27042555
43glutamate receptor signaling pathway (GO:0007215)3.26104766
44presynaptic membrane assembly (GO:0097105)3.20068061
45neurotransmitter transport (GO:0006836)3.19432870
46negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.19304813
47regulation of ARF GTPase activity (GO:0032312)3.18118774
48layer formation in cerebral cortex (GO:0021819)3.17521620
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.17356384
50positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.16485506
51regulation of postsynaptic membrane potential (GO:0060078)3.15721475
52regulation of synapse maturation (GO:0090128)3.14979752
53protein localization to endosome (GO:0036010)3.11289825
54gamma-aminobutyric acid signaling pathway (GO:0007214)3.06652257
55cellular response to catecholamine stimulus (GO:0071870)3.06295849
56cellular response to monoamine stimulus (GO:0071868)3.06295849
57establishment of mitochondrion localization (GO:0051654)3.05530336
58behavioral defense response (GO:0002209)3.03059921
59behavioral fear response (GO:0001662)3.03059921
60retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.00794022
61negative regulation of microtubule polymerization (GO:0031115)2.98297898
62regulation of synaptic plasticity (GO:0048167)2.98161136
63positive regulation of neurotransmitter transport (GO:0051590)2.97993383
64negative regulation of synaptic transmission, GABAergic (GO:0032229)2.97714107
65cerebellar granule cell differentiation (GO:0021707)2.97639852
66positive regulation of synapse assembly (GO:0051965)2.96685102
67neuronal ion channel clustering (GO:0045161)2.95010097
68negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.94840165
69negative regulation of cell killing (GO:0031342)2.94840165
70negative regulation of cell size (GO:0045792)2.94216222
71innervation (GO:0060384)2.93399329
72synaptic vesicle endocytosis (GO:0048488)2.92291674
73gamma-aminobutyric acid transport (GO:0015812)2.91980702
74cell migration in hindbrain (GO:0021535)2.91380335
75regulation of neurotransmitter secretion (GO:0046928)2.90896531
76fear response (GO:0042596)2.90774023
77negative regulation of catecholamine secretion (GO:0033604)2.90431029
78cell communication by electrical coupling (GO:0010644)2.90044656
79regulation of neurotransmitter levels (GO:0001505)2.86414337
80cerebellar Purkinje cell layer development (GO:0021680)2.86067985
81dendritic spine morphogenesis (GO:0060997)2.84673003
82response to histamine (GO:0034776)2.84348821
83protein retention in ER lumen (GO:0006621)2.84297934
84positive regulation of neurotransmitter secretion (GO:0001956)2.83018238
85regulation of synaptic transmission, glutamatergic (GO:0051966)2.81505060
86long-term memory (GO:0007616)2.80357035
87positive regulation of synaptic transmission, GABAergic (GO:0032230)2.79497158
88positive regulation of fibroblast migration (GO:0010763)2.77356266
89regulation of defense response to virus by virus (GO:0050690)2.77066867
90presynaptic membrane organization (GO:0097090)2.74871030
91female mating behavior (GO:0060180)2.74495942
92membrane hyperpolarization (GO:0060081)2.73113589
93negative regulation of erythrocyte differentiation (GO:0045647)2.72744136
94Rac protein signal transduction (GO:0016601)2.71825074
95cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.71510282
96establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.70083895
97mitochondrion transport along microtubule (GO:0047497)2.70083895
98regulation of glutamate secretion (GO:0014048)2.69457552
99regulation of synapse organization (GO:0050807)2.68994175
100barbed-end actin filament capping (GO:0051016)2.68600474
101dendrite morphogenesis (GO:0048813)2.68475196
102regulation of female receptivity (GO:0045924)2.67707960
103cell-cell junction maintenance (GO:0045217)2.67191455
104regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.67103018
105transferrin transport (GO:0033572)2.66133496
106axon extension (GO:0048675)2.65877076
107COPI coating of Golgi vesicle (GO:0048205)2.64560912
108Golgi transport vesicle coating (GO:0048200)2.64560912
109membrane depolarization (GO:0051899)2.64194775
110regulation of neurotransmitter transport (GO:0051588)2.63941860
111G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.62443995
112establishment of nucleus localization (GO:0040023)2.62349541
113G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.61622017
114positive regulation of synaptic transmission (GO:0050806)2.60597646
115activation of protein kinase A activity (GO:0034199)2.60261594
116synaptic vesicle transport (GO:0048489)2.58827641
117establishment of synaptic vesicle localization (GO:0097480)2.58827641
118synapse organization (GO:0050808)2.58469931
119cochlea development (GO:0090102)2.58079683
120behavioral response to cocaine (GO:0048148)2.55584821
121regulation of vesicle fusion (GO:0031338)2.55293868
122auditory behavior (GO:0031223)2.55119727
123positive regulation of protein dephosphorylation (GO:0035307)2.54896324
124learning (GO:0007612)2.54818890
125energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.54683701
126ATP hydrolysis coupled proton transport (GO:0015991)2.54683701
127sodium ion export (GO:0071436)2.52149018
128adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.51599435
129intracellular estrogen receptor signaling pathway (GO:0030520)2.51515112
130regulation of NFAT protein import into nucleus (GO:0051532)2.50907968
131amino acid import (GO:0043090)2.48380138
132response to monoamine (GO:0071867)2.45373713
133response to catecholamine (GO:0071869)2.45373713
134negative regulation of cAMP-mediated signaling (GO:0043951)2.36122023
135regulation of extracellular matrix disassembly (GO:0010715)2.35858081
136neuron projection extension (GO:1990138)2.35529762
137protein targeting to plasma membrane (GO:0072661)2.34702261
138dopamine receptor signaling pathway (GO:0007212)2.33254424
139ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.30826775
140maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.29828651
141cytoskeletal anchoring at plasma membrane (GO:0007016)2.29653164
142semaphorin-plexin signaling pathway (GO:0071526)2.29557210
143chondroitin sulfate catabolic process (GO:0030207)2.29420525
144positive regulation of CREB transcription factor activity (GO:0032793)2.27386737
145L-amino acid import (GO:0043092)2.27233222
146dendritic spine organization (GO:0097061)2.26391843
147response to parathyroid hormone (GO:0071107)2.25897366
148cellular potassium ion homeostasis (GO:0030007)2.25779113
149activation of JUN kinase activity (GO:0007257)2.25772585
150negative regulation of Ras protein signal transduction (GO:0046580)2.25125931
151peptidyl-tyrosine autophosphorylation (GO:0038083)2.21732880
152cell junction maintenance (GO:0034331)2.20415753
153regulation of amyloid precursor protein catabolic process (GO:1902991)2.19427326
154respiratory system process (GO:0003016)2.17358098
155histone H3-K9 demethylation (GO:0033169)2.16824087
156signal complex assembly (GO:0007172)2.16254539
157negative regulation of small GTPase mediated signal transduction (GO:0051058)2.16129475
158positive regulation by symbiont of host defense response (GO:0052509)2.14740965
159modulation by symbiont of host defense response (GO:0052031)2.14740965
160modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.14740965
161modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.14740965
162positive regulation by organism of defense response of other organism involved in symbiotic interact2.14740965
163modulation by symbiont of host immune response (GO:0052553)2.14740965
164negative regulation of necrotic cell death (GO:0060547)2.14482874
165stress fiber assembly (GO:0043149)2.14188148
166neuromuscular process controlling balance (GO:0050885)2.12774740
167negative regulation of catenin import into nucleus (GO:0035414)2.12288379

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.76472989
2GBX2_23144817_ChIP-Seq_PC3_Human3.75649838
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.72175522
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.55729892
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.01085519
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99727831
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.86979182
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.86391321
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85021373
10* LXR_22292898_ChIP-Seq_THP-1_Human2.76976917
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73715976
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59087932
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59087932
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56704846
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54528760
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.54383815
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49492712
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.48712623
19REST_21632747_ChIP-Seq_MESCs_Mouse2.46257636
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44091749
21VDR_21846776_ChIP-Seq_THP-1_Human2.43929986
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41993770
23KDM2B_26808549_Chip-Seq_K562_Human2.36641972
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.36611559
25KDM2B_26808549_Chip-Seq_DND41_Human2.36611182
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.25584759
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.18910763
28MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17302908
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14874232
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.10988743
31CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06278691
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.98793283
33* RNF2_27304074_Chip-Seq_ESCs_Mouse1.95409762
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88727061
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.88629038
36KDM2B_26808549_Chip-Seq_JURKAT_Human1.84325058
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.84283314
38ZNF274_21170338_ChIP-Seq_K562_Hela1.81806933
39TCF7_22412390_ChIP-Seq_EML_Mouse1.80909030
40SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.80799605
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79599006
42DROSHA_22980978_ChIP-Seq_HELA_Human1.76156182
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72731651
44SMC4_20622854_ChIP-Seq_HELA_Human1.71959485
45TAF15_26573619_Chip-Seq_HEK293_Human1.70998590
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.70854357
47RACK7_27058665_Chip-Seq_MCF-7_Human1.70732348
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69250484
49P68_20966046_ChIP-Seq_HELA_Human1.63827513
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.61973891
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61003531
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58770091
53SA1_27219007_Chip-Seq_ERYTHROID_Human1.58509656
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58402862
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58250515
56GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.57854718
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.57679873
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56689116
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55885186
60MYC_22102868_ChIP-Seq_BL_Human1.54279476
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54107899
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54039248
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53966686
64CTCF_27219007_Chip-Seq_ERYTHROID_Human1.51198221
65SMAD4_21799915_ChIP-Seq_A2780_Human1.50222644
66FUS_26573619_Chip-Seq_HEK293_Human1.49156831
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.47435386
68UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.45461417
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45433318
70CTCF_27219007_Chip-Seq_Bcells_Human1.45212347
71TET1_21490601_ChIP-Seq_MESCs_Mouse1.40531676
72ZFP281_27345836_Chip-Seq_ESCs_Mouse1.39878690
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39185432
74SOX2_21211035_ChIP-Seq_LN229_Gbm1.37770741
75P300_19829295_ChIP-Seq_ESCs_Human1.35361322
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34933814
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34869823
78EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33196370
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32817691
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32148280
81MAF_26560356_Chip-Seq_TH2_Human1.31993449
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31240182
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.30657476
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30286223
85DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29738357
86TP53_22127205_ChIP-Seq_IMR90_Human1.29734889
87SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28935200
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28808502
89RING1B_27294783_Chip-Seq_NPCs_Mouse1.27000484
90CREB1_26743006_Chip-Seq_LNCaP_Human1.26653093
91TP53_20018659_ChIP-ChIP_R1E_Mouse1.25264751
92ELF1_20517297_ChIP-Seq_JURKAT_Human1.24934198
93AR_21572438_ChIP-Seq_LNCaP_Human1.23531370
94PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23524307
95MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.22138476
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21440483
97P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20902125
98* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18882016
99YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18748166
100* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18723671
101MAF_26560356_Chip-Seq_TH1_Human1.18130992
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17401887
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16402052
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16240573
105SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15984435
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15500257
107UTX_26944678_Chip-Seq_JUKART_Human1.15086204
108RING1B_27294783_Chip-Seq_ESCs_Mouse1.14137217
109OCT4_19829295_ChIP-Seq_ESCs_Human1.13944167
110SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13924632
111CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.13071077
112* BCL6_27268052_Chip-Seq_Bcells_Human1.13067636
113AR_19668381_ChIP-Seq_PC3_Human1.12285054
114SPI1_23127762_ChIP-Seq_K562_Human1.12007153
115AR_25329375_ChIP-Seq_VCAP_Human1.11819434
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11141857
117CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09314428
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08799473
119VDR_24763502_ChIP-Seq_THP-1_Human1.08253262
120STAT3_23295773_ChIP-Seq_U87_Human1.08253169
121RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08070368
122SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07707537
123* RNF2_27304074_Chip-Seq_NSC_Mouse1.07640204
124* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06771479
125THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06647159
126* BCOR_27268052_Chip-Seq_Bcells_Human1.05639447
127ESR2_21235772_ChIP-Seq_MCF-7_Human1.05338583
128PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05062387
129TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03448765
130TP53_23651856_ChIP-Seq_MEFs_Mouse1.03209876
131SMAD3_21741376_ChIP-Seq_EPCs_Human1.02976310
132PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02365306
133* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00702356
134RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00439312
135TP63_22573176_ChIP-Seq_HFKS_Human1.00399522
136SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00072706
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95810360
138ARNT_22903824_ChIP-Seq_MCF-7_Human0.95768681
139NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95591188
140DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95482808
141EWS_26573619_Chip-Seq_HEK293_Human0.94644921
142CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94559670
143HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94558322
144SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94274305
145POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93289371
146OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93286165
147TRIM28_21343339_ChIP-Seq_HEK293_Human0.91879599
148WT1_19549856_ChIP-ChIP_CCG9911_Human0.90713270
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90702767
150MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89445956
151FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88038326
152* JUN_21703547_ChIP-Seq_K562_Human0.87593848
153POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87290033
154RUNX2_22187159_ChIP-Seq_PCA_Human0.87195951
155TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87152519
156SOX9_26525672_Chip-Seq_HEART_Mouse0.86641093
157* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86210661
158HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.85951752
159SALL1_21062744_ChIP-ChIP_HESCs_Human0.85891920
160* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83188644
161SOX2_16153702_ChIP-ChIP_HESCs_Human0.82205402
162PIAS1_25552417_ChIP-Seq_VCAP_Human0.81153782

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.10746736
2MP0003880_abnormal_central_pattern3.63881006
3MP0003635_abnormal_synaptic_transmissio3.37054690
4MP0003122_maternal_imprinting3.31464677
5MP0008260_abnormal_autophagy3.26696131
6MP0003705_abnormal_hypodermis_morpholog3.22449554
7MP0009780_abnormal_chondrocyte_physiolo3.15943244
8MP0004270_analgesia2.90121285
9MP0002063_abnormal_learning/memory/cond2.81056850
10MP0009745_abnormal_behavioral_response2.53152915
11MP0002572_abnormal_emotion/affect_behav2.45202365
12MP0005058_abnormal_lysosome_morphology2.38401333
13MP0002064_seizures2.31609935
14MP0001958_emphysema2.24984103
15MP0001968_abnormal_touch/_nociception2.17160920
16MP0009046_muscle_twitch2.15868599
17MP0004130_abnormal_muscle_cell2.10015246
18MP0006276_abnormal_autonomic_nervous2.04490627
19MP0001188_hyperpigmentation2.03841454
20MP0004145_abnormal_muscle_electrophysio2.03637845
21MP0002734_abnormal_mechanical_nocicepti1.99615518
22MP0005646_abnormal_pituitary_gland1.92401654
23MP0002736_abnormal_nociception_after1.86955272
24MP0002272_abnormal_nervous_system1.83826580
25MP0003123_paternal_imprinting1.83161510
26MP0002249_abnormal_larynx_morphology1.82916481
27MP0001348_abnormal_lacrimal_gland1.82763421
28MP0000604_amyloidosis1.80071481
29MP0002733_abnormal_thermal_nociception1.74794438
30MP0005248_abnormal_Harderian_gland1.73161856
31MP0005171_absent_coat_pigmentation1.73066964
32MP0002822_catalepsy1.72670926
33MP0002184_abnormal_innervation1.72004834
34MP0000013_abnormal_adipose_tissue1.71714274
35MP0003121_genomic_imprinting1.70360848
36MP0002557_abnormal_social/conspecific_i1.70190085
37MP0003283_abnormal_digestive_organ1.69063030
38MP0000778_abnormal_nervous_system1.67992999
39MP0002653_abnormal_ependyma_morphology1.66840243
40MP0002735_abnormal_chemical_nociception1.64774380
41MP0001501_abnormal_sleep_pattern1.64656976
42MP0003279_aneurysm1.63654722
43MP0004858_abnormal_nervous_system1.61769763
44MP0005645_abnormal_hypothalamus_physiol1.59805841
45MP0001486_abnormal_startle_reflex1.56375597
46MP0001440_abnormal_grooming_behavior1.56202804
47MP0003183_abnormal_peptide_metabolism1.53921580
48MP0005623_abnormal_meninges_morphology1.51245238
49MP0002067_abnormal_sensory_capabilities1.50810072
50MP0003787_abnormal_imprinting1.50404545
51MP0001970_abnormal_pain_threshold1.49103383
52MP0003690_abnormal_glial_cell1.46557329
53MP0004811_abnormal_neuron_physiology1.42906599
54MP0003634_abnormal_glial_cell1.41559793
55MP0002909_abnormal_adrenal_gland1.41296427
56MP0005423_abnormal_somatic_nervous1.40604582
57MP0001529_abnormal_vocalization1.40239003
58MP0001502_abnormal_circadian_rhythm1.37505506
59MP0009278_abnormal_bone_marrow1.37501928
60MP0010386_abnormal_urinary_bladder1.36668978
61MP0000678_abnormal_parathyroid_gland1.32439279
62MP0000747_muscle_weakness1.31413280
63MP0000955_abnormal_spinal_cord1.31337565
64MP0004233_abnormal_muscle_weight1.30740056
65MP0003436_decreased_susceptibility_to1.30421891
66MP0003191_abnormal_cellular_cholesterol1.30374289
67MP0005386_behavior/neurological_phenoty1.29340429
68MP0004924_abnormal_behavior1.29340429
69MP0001849_ear_inflammation1.27284757
70MP0003303_peritoneal_inflammation1.27221905
71MP0003385_abnormal_body_wall1.25558350
72MP0005451_abnormal_body_composition1.25111450
73MP0003091_abnormal_cell_migration1.21684062
74MP0000759_abnormal_skeletal_muscle1.21260286
75MP0000003_abnormal_adipose_tissue1.18462609
76MP0009840_abnormal_foam_cell1.18145584
77MP0003879_abnormal_hair_cell1.18027768
78MP0005503_abnormal_tendon_morphology1.15663755
79MP0002066_abnormal_motor_capabilities/c1.14176052
80MP0002837_dystrophic_cardiac_calcinosis1.13116307
81MP0008569_lethality_at_weaning1.12976415
82MP0000751_myopathy1.10536643
83MP0002876_abnormal_thyroid_physiology1.09095050
84MP0000534_abnormal_ureter_morphology1.08783426
85MP0002882_abnormal_neuron_morphology1.06342805
86MP0002152_abnormal_brain_morphology1.05943636
87MP0004510_myositis1.05755357
88MP0000920_abnormal_myelination1.05090855
89MP0000631_abnormal_neuroendocrine_gland1.04603412
90MP0005375_adipose_tissue_phenotype1.02036723
91MP0001299_abnormal_eye_distance/1.01123463
92MP0002971_abnormal_brown_adipose0.99189840
93MP0000733_abnormal_muscle_development0.96288486
94MP0003119_abnormal_digestive_system0.95960257
95MP0001984_abnormal_olfaction0.94001835
96MP0008874_decreased_physiological_sensi0.93128859
97MP0003300_gastrointestinal_ulcer0.90352125
98MP0000750_abnormal_muscle_regeneration0.89416454
99MP0004085_abnormal_heartbeat0.88930576
100MP0005666_abnormal_adipose_tissue0.88908136
101MP0003632_abnormal_nervous_system0.88267799
102MP0001542_abnormal_bone_strength0.87793475
103MP0002069_abnormal_eating/drinking_beha0.87009970
104MP0003942_abnormal_urinary_system0.86893435
105MP0001905_abnormal_dopamine_level0.86201706
106MP0004272_abnormal_basement_membrane0.85918812
107MP0003763_abnormal_thymus_physiology0.85526758
108MP0004142_abnormal_muscle_tone0.83542949
109MP0009384_cardiac_valve_regurgitation0.83108066
110MP0000049_abnormal_middle_ear0.81945635
111MP0003045_fibrosis0.78502197
112MP0003566_abnormal_cell_adhesion0.76457895
113MP0005377_hearing/vestibular/ear_phenot0.75575952
114MP0003878_abnormal_ear_physiology0.75575952
115MP0004883_abnormal_blood_vessel0.75367348
116MP0009250_abnormal_appendicular_skeleto0.74043510
117MP0001986_abnormal_taste_sensitivity0.73610591
118MP0002896_abnormal_bone_mineralization0.73470703
119MP0001177_atelectasis0.72768648
120MP0000749_muscle_degeneration0.72280573
121MP0003861_abnormal_nervous_system0.72241233
122MP0004885_abnormal_endolymph0.70768411
123MP0001270_distended_abdomen0.70482503
124MP0005409_darkened_coat_color0.70161763
125MP0004087_abnormal_muscle_fiber0.69142606
126MP0000026_abnormal_inner_ear0.69040913
127MP0000681_abnormal_thyroid_gland0.68342402
128MP0002751_abnormal_autonomic_nervous0.68120479
129MP0003115_abnormal_respiratory_system0.68057131
130MP0002419_abnormal_innate_immunity0.67669940
131MP0003948_abnormal_gas_homeostasis0.67490591
132MP0003329_amyloid_beta_deposits0.67440466
133MP0002970_abnormal_white_adipose0.67301711
134MP0002269_muscular_atrophy0.67198045
135MP0002638_abnormal_pupillary_reflex0.65634350
136MP0001664_abnormal_digestion0.64287350
137MP0004264_abnormal_extraembryonic_tissu0.63963891
138MP0003755_abnormal_palate_morphology0.63615369
139MP0004215_abnormal_myocardial_fiber0.63328519
140MP0003633_abnormal_nervous_system0.61810586
141MP0001943_abnormal_respiration0.61545018
142MP0006138_congestive_heart_failure0.61401832
143MP0003631_nervous_system_phenotype0.60660459
144MP0005535_abnormal_body_temperature0.60390213
145MP0002108_abnormal_muscle_morphology0.57410968
146MP0002081_perinatal_lethality0.56518156
147MP0008438_abnormal_cutaneous_collagen0.56484879
148MP0003137_abnormal_impulse_conducting0.56412978
149MP0003172_abnormal_lysosome_physiology0.55988971
150MP0005394_taste/olfaction_phenotype0.55985097
151MP0005499_abnormal_olfactory_system0.55985097

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.05495072
2Atonic seizures (HP:0010819)4.07866639
3Epileptic encephalopathy (HP:0200134)4.07111070
4Focal seizures (HP:0007359)3.78159784
5Visual hallucinations (HP:0002367)3.61229887
6Supranuclear gaze palsy (HP:0000605)3.54633966
7Myokymia (HP:0002411)3.45451795
8Amblyopia (HP:0000646)3.28414988
9Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.08281384
10Febrile seizures (HP:0002373)2.91914276
11Absence seizures (HP:0002121)2.89152814
12Broad face (HP:0000283)2.74428528
13Hyperventilation (HP:0002883)2.74047577
14Cervical subluxation (HP:0003308)2.68087399
15Papilledema (HP:0001085)2.67113236
16Increased variability in muscle fiber diameter (HP:0003557)2.65965229
17Generalized tonic-clonic seizures (HP:0002069)2.65108868
18Epileptiform EEG discharges (HP:0011182)2.63946964
19Protrusio acetabuli (HP:0003179)2.60906498
20Hyperacusis (HP:0010780)2.60616523
21Progressive cerebellar ataxia (HP:0002073)2.58988603
22Neuronal loss in central nervous system (HP:0002529)2.54698562
23Obstructive sleep apnea (HP:0002870)2.54432959
24Dialeptic seizures (HP:0011146)2.53944025
25Poor eye contact (HP:0000817)2.52877440
26EEG with generalized epileptiform discharges (HP:0011198)2.51294421
27Peripheral hypomyelination (HP:0007182)2.50833015
28Neurofibrillary tangles (HP:0002185)2.49156839
29Distal upper limb amyotrophy (HP:0007149)2.46954013
30Upper limb amyotrophy (HP:0009129)2.46954013
31Hypsarrhythmia (HP:0002521)2.42323521
32Increased connective tissue (HP:0009025)2.40267618
33Narrow nasal bridge (HP:0000446)2.36277960
34Hand muscle atrophy (HP:0009130)2.34875465
35Stridor (HP:0010307)2.33695047
36Vertebral compression fractures (HP:0002953)2.33679479
37Impaired smooth pursuit (HP:0007772)2.33190681
38Premature rupture of membranes (HP:0001788)2.29698725
39Impaired vibration sensation in the lower limbs (HP:0002166)2.29130357
40Limb dystonia (HP:0002451)2.28246757
41Cerebral inclusion bodies (HP:0100314)2.28177215
42Sleep apnea (HP:0010535)2.27657337
43Eczematoid dermatitis (HP:0000976)2.26781365
44Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.24566498
45J-shaped sella turcica (HP:0002680)2.23445015
46Mitral regurgitation (HP:0001653)2.23269945
47Depression (HP:0000716)2.22158293
48Hyperthyroidism (HP:0000836)2.21840405
49Centrally nucleated skeletal muscle fibers (HP:0003687)2.21753752
50Abnormality of skeletal muscle fiber size (HP:0012084)2.19941025
51Failure to thrive in infancy (HP:0001531)2.19428715
52Excessive salivation (HP:0003781)2.19161565
53Drooling (HP:0002307)2.19161565
54Atelectasis (HP:0100750)2.16600714
55Spastic gait (HP:0002064)2.14222611
56Hypoventilation (HP:0002791)2.13704323
57Severe visual impairment (HP:0001141)2.12019904
58Protruding tongue (HP:0010808)2.11988645
59Truncal ataxia (HP:0002078)2.09983242
60Abnormal social behavior (HP:0012433)2.08243766
61Impaired social interactions (HP:0000735)2.08243766
62Type 1 muscle fiber predominance (HP:0003803)2.07801959
63Spinal rigidity (HP:0003306)2.07252453
64Blue irides (HP:0000635)2.05567952
65Disproportionate tall stature (HP:0001519)2.05153216
66Abnormality of the labia minora (HP:0012880)2.04045774
67Biconcave vertebral bodies (HP:0004586)2.02497276
68Broad-based gait (HP:0002136)2.02480853
69Polyphagia (HP:0002591)2.02146459
70Bowel incontinence (HP:0002607)2.01065883
71Ankle clonus (HP:0011448)2.01022693
72Flared iliac wings (HP:0002869)2.00730948
73Hemiparesis (HP:0001269)1.98925410
74Torticollis (HP:0000473)1.98147279
75Abnormal eating behavior (HP:0100738)1.96873120
76Pheochromocytoma (HP:0002666)1.96362012
77Diplopia (HP:0000651)1.95046915
78Abnormality of binocular vision (HP:0011514)1.95046915
79Turricephaly (HP:0000262)1.93273768
80Bowel diverticulosis (HP:0005222)1.93137456
81Deep palmar crease (HP:0006191)1.90180585
82Hypercortisolism (HP:0001578)1.90021177
83Dysostosis multiplex (HP:0000943)1.89590138
84Abnormality of ocular smooth pursuit (HP:0000617)1.89285385
85Heterochromia iridis (HP:0001100)1.89243285
86Peritonitis (HP:0002586)1.88624394
87Abnormality of the calcaneus (HP:0008364)1.88143633
88Long palpebral fissure (HP:0000637)1.87325872
89Intellectual disability, profound (HP:0002187)1.87257536
90Bradykinesia (HP:0002067)1.86983456
91Difficulty running (HP:0009046)1.86772481
92Mildly elevated creatine phosphokinase (HP:0008180)1.86654539
93Exercise-induced myalgia (HP:0003738)1.86584312
94Difficulty climbing stairs (HP:0003551)1.86507817
95Bladder diverticulum (HP:0000015)1.86094160
96Spinal canal stenosis (HP:0003416)1.85678020
97Dilatation of the ascending aorta (HP:0005111)1.85610595
98Focal dystonia (HP:0004373)1.85561933
99Apathy (HP:0000741)1.85560127
100Gait imbalance (HP:0002141)1.83959130
101Achilles tendon contracture (HP:0001771)1.82155224
102Anxiety (HP:0000739)1.82140002
103Abnormal large intestine physiology (HP:0012700)1.82013444
104Rapidly progressive (HP:0003678)1.81656180
105Diminished motivation (HP:0000745)1.81432146
106Annular pancreas (HP:0001734)1.79579161
107Abnormality of the lower motor neuron (HP:0002366)1.78863175
108Gaze-evoked nystagmus (HP:0000640)1.78744213
109Slow saccadic eye movements (HP:0000514)1.77854833
110Asymmetric septal hypertrophy (HP:0001670)1.77220402
111Aplasia/Hypoplasia of the brainstem (HP:0007362)1.77208646
112Hypoplasia of the brainstem (HP:0002365)1.77208646
113Dysdiadochokinesis (HP:0002075)1.76874193
114Abnormality of pain sensation (HP:0010832)1.76450988
115Impaired pain sensation (HP:0007328)1.76450988
116Neoplasm of the adrenal cortex (HP:0100641)1.75463811
117Vascular tortuosity (HP:0004948)1.74266602
118Broad distal phalanx of finger (HP:0009836)1.74126063
119Shoulder girdle muscle weakness (HP:0003547)1.74077353
120Hammertoe (HP:0001765)1.73897648
121Akinesia (HP:0002304)1.73864338
122Thin bony cortex (HP:0002753)1.73723514
123Abnormality of glycosphingolipid metabolism (HP:0004343)1.73591370
124Abnormality of glycolipid metabolism (HP:0010969)1.73591370
125Abnormality of liposaccharide metabolism (HP:0010968)1.73591370
126Shallow orbits (HP:0000586)1.72403535
127Foot dorsiflexor weakness (HP:0009027)1.72327573
128Arterial tortuosity (HP:0005116)1.71983706
129Aortic aneurysm (HP:0004942)1.71871013
130Calcaneovalgus deformity (HP:0001848)1.70995657
131Hepatoblastoma (HP:0002884)1.70186937
132Craniofacial dystonia (HP:0012179)1.69717222
133Aneurysm (HP:0002617)1.69554878
134Truncus arteriosus (HP:0001660)1.69105560
135Supernumerary nipples (HP:0002558)1.69032851
136Scapular winging (HP:0003691)1.68927647
137Urinary urgency (HP:0000012)1.68477917
138Insomnia (HP:0100785)1.68433721
139Lower limb muscle weakness (HP:0007340)1.67936006
140Cellulitis (HP:0100658)1.67882389
141Orthostatic hypotension (HP:0001278)1.67850927
142Distal lower limb amyotrophy (HP:0008944)1.67270829
143Gingivitis (HP:0000230)1.67154677
144Postural instability (HP:0002172)1.66524043
145Renal duplication (HP:0000075)1.66362390
146Absent speech (HP:0001344)1.66299772
147Macroglossia (HP:0000158)1.65801743
148Scanning speech (HP:0002168)1.64665217
149Dislocated radial head (HP:0003083)1.64545073
150Urinary bladder sphincter dysfunction (HP:0002839)1.64371365
151Genetic anticipation (HP:0003743)1.64175340
152Resting tremor (HP:0002322)1.62290668
153Ulnar bowing (HP:0003031)1.62197094
154Long toe (HP:0010511)1.62162464
155Shawl scrotum (HP:0000049)1.61929234
156Slender build (HP:0001533)1.61471026
157Neuroendocrine neoplasm (HP:0100634)1.61207530
158Onion bulb formation (HP:0003383)1.60929525
159Abnormality of calcium-phosphate metabolism (HP:0100530)1.60703112
160Myopathic facies (HP:0002058)1.60271435
161Poor suck (HP:0002033)1.60157878
162Abnormality of polysaccharide metabolism (HP:0011012)1.59720545
163Abnormality of glycosaminoglycan metabolism (HP:0004371)1.59720545
164Abnormality of mucopolysaccharide metabolism (HP:0011020)1.59720545
165Complete atrioventricular canal defect (HP:0001674)1.58859557
166Atrioventricular canal defect (HP:0006695)1.58604514
167Dysmetric saccades (HP:0000641)1.58235384
168Hypoplasia of the odontoid process (HP:0003311)1.57979158
169Nephrogenic diabetes insipidus (HP:0009806)1.56614005
170Exotropia (HP:0000577)1.55578768
171Impaired vibratory sensation (HP:0002495)1.55489651
172Action tremor (HP:0002345)1.55459283
173Fetal akinesia sequence (HP:0001989)1.55010953
174Pointed chin (HP:0000307)1.54661989
175Abnormal hair whorl (HP:0010721)1.54312646
176Cerebral aneurysm (HP:0004944)1.53653028
177Specific learning disability (HP:0001328)1.53334581

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.10538678
2EPHA43.55823448
3MAP3K43.01777503
4MAP2K72.70047025
5MARK12.65714108
6MINK12.63411776
7CASK2.49014329
8ICK2.42611997
9AKT32.39666151
10MAP3K92.31042645
11TAOK12.25245636
12CDK192.18675239
13MAP2K42.12621299
14MAP3K122.12046164
15ERN12.00060129
16GRK51.97879383
17DAPK11.91982298
18PRPF4B1.91497913
19MAP3K111.89349170
20MARK21.89223132
21EPHB11.88674456
22CAMKK21.87316649
23MAP3K61.83593738
24DAPK21.73508955
25PRKD31.72600256
26INSRR1.68013195
27SIK11.67759396
28TNIK1.66095171
29CAMKK11.56404318
30ARAF1.56308826
31PLK21.56203873
32MAPK131.55428151
33TNK21.54429404
34MAP2K31.50014225
35PRKD21.47386019
36NTRK21.47109771
37TSSK61.47040392
38PKN21.46201103
39RIPK11.45508734
40LATS21.45505144
41NEK11.39619892
42RIPK41.38429870
43TTN1.33944914
44CDK81.33404143
45MOS1.29109848
46DYRK1B1.28529321
47KSR11.25307101
48TESK11.21217008
49BRAF1.19616017
50PAK61.16693484
51FGFR41.16199427
52MAPK121.15637149
53SIK21.15249825
54WNK31.14830340
55TYK21.12167180
56DDR21.10319982
57ERBB31.07515088
58SGK21.07327289
59BLK1.07266686
60CDK51.06285898
61PRKCG1.05610162
62SCYL21.03457883
63NTRK11.00649208
64FES0.99670019
65GRK70.99313603
66MAP4K10.95874645
67EEF2K0.95540410
68CDK180.94930726
69UHMK10.90986181
70CDK150.90312116
71SMG10.85751398
72MAP3K10.85122642
73CDK140.84499173
74SGK4940.83651961
75SGK2230.83651961
76CDK11A0.80917248
77PHKG20.79186929
78PHKG10.79186929
79FER0.77511049
80PLK30.74588895
81EPHA30.74540660
82PTK2B0.74264732
83PDGFRA0.72288655
84KSR20.71619278
85ADRBK10.71180315
86SGK30.70650620
87GRK60.70346531
88ZAP700.70261581
89TGFBR20.69500186
90TYRO30.69328814
91PRKCH0.69120727
92CAMK2A0.68504063
93PASK0.68321267
94PDPK10.68315183
95CAMK1G0.67769775
96HCK0.67160742
97PAK30.66923700
98CAMK2B0.66065964
99CSK0.65921521
100RPS6KA20.63078757
101STK110.62304707
102JAK20.62078586
103PTK60.61800912
104NME10.61310159
105MAP3K30.61241842
106RET0.60737902
107CDK120.60066943
108PDK10.60016728
109TAOK20.58160371
110TESK20.55660257
111PIM20.55575623
112CAMK10.55280223
113FYN0.54373780
114CAMK40.52315601
115BRSK10.51375222
116STK380.51099254
117JAK10.50470606
118MTOR0.50374081
119PDK30.50088047
120PDK40.50088047
121PRKCE0.50040109
122RPS6KC10.49815633
123RPS6KL10.49815633
124ZAK0.49426085
125CCNB10.48728460
126EPHB20.48378007
127IRAK40.47912668
128PRKD10.47610528
129DYRK20.46956164
130PRKAA10.46530741
131MAP2K10.46298078
132CSF1R0.44982852
133PRKCZ0.44764987
134PTK20.43677816
135RPS6KB10.38901259
136RAF10.37850224
137CSNK1G20.36406254
138SGK10.33420979
139RPS6KA30.33281395
140DYRK1A0.31246791
141SIK30.27120840
142PNCK0.27053101
143MATK0.26817760
144CSNK1E0.26589425
145MAP3K70.25799279
146TRIB30.25696410
147DAPK30.25453103
148ALK0.25416551
149CAMK1D0.25031066
150CDC42BPA0.24928788
151MAPK70.24075032

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.73861732
2Synaptic vesicle cycle_Homo sapiens_hsa047213.61720329
3GABAergic synapse_Homo sapiens_hsa047272.52012284
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.48485424
5Long-term potentiation_Homo sapiens_hsa047202.43682038
6Olfactory transduction_Homo sapiens_hsa047402.40092273
7Amphetamine addiction_Homo sapiens_hsa050312.33716763
8Circadian entrainment_Homo sapiens_hsa047132.28725848
9Collecting duct acid secretion_Homo sapiens_hsa049662.14998211
10Morphine addiction_Homo sapiens_hsa050322.13921471
11Dopaminergic synapse_Homo sapiens_hsa047282.07794610
12Insulin secretion_Homo sapiens_hsa049112.06656063
13Glutamatergic synapse_Homo sapiens_hsa047242.01972837
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92905780
15Vibrio cholerae infection_Homo sapiens_hsa051101.87435188
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.77847069
17Taste transduction_Homo sapiens_hsa047421.69859750
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62389932
19Other glycan degradation_Homo sapiens_hsa005111.62281684
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60244721
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59626617
22Serotonergic synapse_Homo sapiens_hsa047261.57694698
23Salivary secretion_Homo sapiens_hsa049701.56522247
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55459714
25Gap junction_Homo sapiens_hsa045401.55103978
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.54550362
27Notch signaling pathway_Homo sapiens_hsa043301.51023761
28Cocaine addiction_Homo sapiens_hsa050301.50252808
29VEGF signaling pathway_Homo sapiens_hsa043701.48194443
30Renin secretion_Homo sapiens_hsa049241.46087808
31Long-term depression_Homo sapiens_hsa047301.45895725
32Cholinergic synapse_Homo sapiens_hsa047251.44578015
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44195016
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40471247
35Oxytocin signaling pathway_Homo sapiens_hsa049211.38282326
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37303088
37Acute myeloid leukemia_Homo sapiens_hsa052211.36531152
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34618510
39Calcium signaling pathway_Homo sapiens_hsa040201.30824701
40GnRH signaling pathway_Homo sapiens_hsa049121.26958390
41Gastric acid secretion_Homo sapiens_hsa049711.24670675
42Renal cell carcinoma_Homo sapiens_hsa052111.21470407
43Melanogenesis_Homo sapiens_hsa049161.17727671
44Osteoclast differentiation_Homo sapiens_hsa043801.16426843
45Chronic myeloid leukemia_Homo sapiens_hsa052201.16175893
46Glioma_Homo sapiens_hsa052141.12278319
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11684352
48Endocytosis_Homo sapiens_hsa041441.06022149
49Oocyte meiosis_Homo sapiens_hsa041141.04296789
50AMPK signaling pathway_Homo sapiens_hsa041521.04041824
51Estrogen signaling pathway_Homo sapiens_hsa049151.03601380
52Prion diseases_Homo sapiens_hsa050201.02437922
53Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01606337
54Inositol phosphate metabolism_Homo sapiens_hsa005621.01121362
55Lysosome_Homo sapiens_hsa041420.98405015
56B cell receptor signaling pathway_Homo sapiens_hsa046620.98361006
57Axon guidance_Homo sapiens_hsa043600.97939348
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97377641
59Pancreatic cancer_Homo sapiens_hsa052120.96828637
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96325692
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94694158
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.94555560
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94127924
64cAMP signaling pathway_Homo sapiens_hsa040240.91851368
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91093839
66Dilated cardiomyopathy_Homo sapiens_hsa054140.87538279
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87458694
68Alcoholism_Homo sapiens_hsa050340.86570254
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.85219170
70ErbB signaling pathway_Homo sapiens_hsa040120.84760058
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84551334
72Cardiac muscle contraction_Homo sapiens_hsa042600.83237660
73Hedgehog signaling pathway_Homo sapiens_hsa043400.82454630
74Wnt signaling pathway_Homo sapiens_hsa043100.81921425
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78706479
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.77995659
77Type II diabetes mellitus_Homo sapiens_hsa049300.77742438
78Chemokine signaling pathway_Homo sapiens_hsa040620.76384937
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73767093
80Glucagon signaling pathway_Homo sapiens_hsa049220.72706389
81Endometrial cancer_Homo sapiens_hsa052130.72092879
82Prolactin signaling pathway_Homo sapiens_hsa049170.71561840
83Tuberculosis_Homo sapiens_hsa051520.71195013
84N-Glycan biosynthesis_Homo sapiens_hsa005100.70490098
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69770516
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69650723
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69482828
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.66852207
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66020104
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65840149
91Thyroid hormone synthesis_Homo sapiens_hsa049180.64003202
92MAPK signaling pathway_Homo sapiens_hsa040100.63834586
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63485902
94Hippo signaling pathway_Homo sapiens_hsa043900.63279560
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62783594
96Oxidative phosphorylation_Homo sapiens_hsa001900.62764169
97Hepatitis B_Homo sapiens_hsa051610.61991255
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60679687
99T cell receptor signaling pathway_Homo sapiens_hsa046600.60560128
100Colorectal cancer_Homo sapiens_hsa052100.58543086
101Circadian rhythm_Homo sapiens_hsa047100.58233113
102Salmonella infection_Homo sapiens_hsa051320.57575684
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.57349800
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57280078
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55452717
106Shigellosis_Homo sapiens_hsa051310.55318781
107Insulin resistance_Homo sapiens_hsa049310.55073939
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54887912
109Hepatitis C_Homo sapiens_hsa051600.54711102
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54613455
111Platelet activation_Homo sapiens_hsa046110.54184746
112Melanoma_Homo sapiens_hsa052180.53490793
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53270305
114Choline metabolism in cancer_Homo sapiens_hsa052310.52874477
115Sulfur relay system_Homo sapiens_hsa041220.52721094
116Rap1 signaling pathway_Homo sapiens_hsa040150.52711799
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.52533578
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50391743
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.50067017
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49704499
121Alzheimers disease_Homo sapiens_hsa050100.46864421
122Insulin signaling pathway_Homo sapiens_hsa049100.46859993
123Ras signaling pathway_Homo sapiens_hsa040140.45578057
124mTOR signaling pathway_Homo sapiens_hsa041500.45074794
125Basal cell carcinoma_Homo sapiens_hsa052170.45049180
126Thyroid cancer_Homo sapiens_hsa052160.43542181
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42432873
128Parkinsons disease_Homo sapiens_hsa050120.40341758
129Phototransduction_Homo sapiens_hsa047440.39211646
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37420724
131Phagosome_Homo sapiens_hsa041450.37284354
132Huntingtons disease_Homo sapiens_hsa050160.34714455
133Non-small cell lung cancer_Homo sapiens_hsa052230.34680245
134Focal adhesion_Homo sapiens_hsa045100.34558181
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.34452858
136Fructose and mannose metabolism_Homo sapiens_hsa000510.33607406
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32274900
138Type I diabetes mellitus_Homo sapiens_hsa049400.31770471
139Maturity onset diabetes of the young_Homo sapiens_hsa049500.30668795

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