KLHL23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gonadal mesoderm development (GO:0007506)6.42332897
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.94738534
3layer formation in cerebral cortex (GO:0021819)4.87439662
4vocalization behavior (GO:0071625)4.67401783
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.64077556
6neuron cell-cell adhesion (GO:0007158)4.55574587
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.50734666
8regulation of glutamate receptor signaling pathway (GO:1900449)4.40159867
9protein localization to synapse (GO:0035418)4.39509358
10locomotory exploration behavior (GO:0035641)4.38690319
11chromatin remodeling at centromere (GO:0031055)4.26850499
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.26020941
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.08915547
14CENP-A containing nucleosome assembly (GO:0034080)3.98268549
15regulation of synaptic vesicle exocytosis (GO:2000300)3.96102244
16dendritic spine morphogenesis (GO:0060997)3.94450521
17synaptic vesicle exocytosis (GO:0016079)3.90974216
18exploration behavior (GO:0035640)3.90680270
19postsynaptic membrane organization (GO:0001941)3.89378102
20synaptic vesicle maturation (GO:0016188)3.84973814
21neuron recognition (GO:0008038)3.83142244
22regulation of synapse structural plasticity (GO:0051823)3.75143870
23pyrimidine nucleobase catabolic process (GO:0006208)3.75100815
24establishment of integrated proviral latency (GO:0075713)3.73309870
25positive regulation of dendritic spine morphogenesis (GO:0061003)3.66857139
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.66278845
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.61090691
28regulation of dendritic spine morphogenesis (GO:0061001)3.54890737
29positive regulation of synapse maturation (GO:0090129)3.51866827
30glutamate receptor signaling pathway (GO:0007215)3.49257560
31positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.48932303
32DNA replication-independent nucleosome organization (GO:0034724)3.48907939
33DNA replication-independent nucleosome assembly (GO:0006336)3.48907939
34histone exchange (GO:0043486)3.48535024
35glutamate secretion (GO:0014047)3.46189170
36establishment of nucleus localization (GO:0040023)3.45053692
37axonal fasciculation (GO:0007413)3.43661137
38cardiac myofibril assembly (GO:0055003)3.43414999
39regulation of synaptic vesicle transport (GO:1902803)3.43043373
40neurotransmitter-gated ion channel clustering (GO:0072578)3.41426530
41cell communication by electrical coupling (GO:0010644)3.40663500
42DNA strand elongation involved in DNA replication (GO:0006271)3.39590421
43synaptic transmission, glutamatergic (GO:0035249)3.39333376
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.37066291
45regulation of long-term neuronal synaptic plasticity (GO:0048169)3.32363661
46central nervous system projection neuron axonogenesis (GO:0021952)3.31984746
47DNA replication checkpoint (GO:0000076)3.27835190
48positive regulation of neurotransmitter secretion (GO:0001956)3.26226898
49neuron-neuron synaptic transmission (GO:0007270)3.24230027
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.23745203
51DNA unwinding involved in DNA replication (GO:0006268)3.22507275
52presynaptic membrane assembly (GO:0097105)3.22019677
53heterochromatin organization (GO:0070828)3.21393196
54DNA strand elongation (GO:0022616)3.20779326
55dendrite morphogenesis (GO:0048813)3.18203393
56negative regulation of microtubule polymerization (GO:0031115)3.17164246
57regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.16116556
58DNA double-strand break processing (GO:0000729)3.12549379
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.12142183
60positive regulation of male gonad development (GO:2000020)3.11940869
61regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.11497584
62DNA replication-dependent nucleosome organization (GO:0034723)3.10886447
63DNA replication-dependent nucleosome assembly (GO:0006335)3.10886447
64innervation (GO:0060384)3.10696662
65regulation of neuronal synaptic plasticity (GO:0048168)3.09213498
66DNA damage response, detection of DNA damage (GO:0042769)3.08119847
67axon extension (GO:0048675)3.06134130
68neurotransmitter secretion (GO:0007269)3.05430824
69regulation of excitatory postsynaptic membrane potential (GO:0060079)3.02193333
70regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.02009228
71regulation of dendritic spine development (GO:0060998)3.01732671
72synapse assembly (GO:0007416)2.99780900
73telomere maintenance via semi-conservative replication (GO:0032201)2.98183636
74regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.98135687
75protein localization to kinetochore (GO:0034501)2.97783476
76regulation of postsynaptic membrane potential (GO:0060078)2.97302581
77auditory behavior (GO:0031223)2.96325685
78nucleobase catabolic process (GO:0046113)2.95687583
79positive regulation of membrane potential (GO:0045838)2.92642081
80activation of protein kinase A activity (GO:0034199)2.92343866
81pre-miRNA processing (GO:0031054)2.92341422
82positive regulation of dendritic spine development (GO:0060999)2.91848691
83kinetochore organization (GO:0051383)2.91311791
84L-serine metabolic process (GO:0006563)2.91103185
85positive regulation of neurotransmitter transport (GO:0051590)2.90224861
86regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.89948206
87regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.88132014
88ATP-dependent chromatin remodeling (GO:0043044)2.86912087
89positive regulation of synapse assembly (GO:0051965)2.86890206
90presynaptic membrane organization (GO:0097090)2.85430436
91regulation of synapse maturation (GO:0090128)2.85320930
92regulation of gene silencing by RNA (GO:0060966)2.84233274
93regulation of posttranscriptional gene silencing (GO:0060147)2.84233274
94regulation of gene silencing by miRNA (GO:0060964)2.84233274
95paraxial mesoderm development (GO:0048339)2.80939089
96G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.80440313
97replication fork processing (GO:0031297)2.79654236
98DNA ligation (GO:0006266)2.79534931
99negative regulation of DNA-dependent DNA replication (GO:2000104)2.78268923
100G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.77691195
101synaptic vesicle endocytosis (GO:0048488)2.77684593
102synapse organization (GO:0050808)2.76706212
103cell migration in hindbrain (GO:0021535)2.76567603
104sister chromatid segregation (GO:0000819)2.76465902
105long-term memory (GO:0007616)2.75356937
106membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.74701046
107regulation of synapse organization (GO:0050807)2.73997104
108regulation of neurotransmitter secretion (GO:0046928)2.72998842
109cochlea development (GO:0090102)2.71381753
110regulation of synapse assembly (GO:0051963)2.71270984
111mitotic sister chromatid segregation (GO:0000070)2.70346196
112response to pheromone (GO:0019236)2.70185656
113regulation of centriole replication (GO:0046599)2.70134359
114proline transport (GO:0015824)2.69135818
115neuronal action potential propagation (GO:0019227)2.68333845
116non-recombinational repair (GO:0000726)2.68109812
117double-strand break repair via nonhomologous end joining (GO:0006303)2.68109812
118glial cell proliferation (GO:0014009)2.67633479
119cerebellar granule cell differentiation (GO:0021707)2.67288674
120transmission of nerve impulse (GO:0019226)2.66935049
121regulation of cell communication by electrical coupling (GO:0010649)2.66865872
122positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.66575353
123nuclear pore complex assembly (GO:0051292)2.66259619
124response to histamine (GO:0034776)2.65995826
125regulation of male gonad development (GO:2000018)2.65223209
126DNA replication initiation (GO:0006270)2.65156966
127regulation of DNA endoreduplication (GO:0032875)2.65025722
128nuclear pore organization (GO:0006999)2.65015413
129mitotic recombination (GO:0006312)2.64246631
130chromatin assembly or disassembly (GO:0006333)2.63747356
131nucleotide-excision repair, DNA gap filling (GO:0006297)2.63577506
132DNA topological change (GO:0006265)2.63220811
133regulation of cAMP-dependent protein kinase activity (GO:2000479)2.62485612
134dendritic spine organization (GO:0097061)2.62445368
135negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.62426615
136negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.62426615
137negative regulation of mitotic sister chromatid segregation (GO:0033048)2.62426615
138negative regulation of mitotic sister chromatid separation (GO:2000816)2.62426615
139negative regulation of sister chromatid segregation (GO:0033046)2.62426615
140negative regulation of synaptic transmission, GABAergic (GO:0032229)2.62116248
141kinetochore assembly (GO:0051382)2.61903801
142establishment of viral latency (GO:0019043)2.61693358
143negative regulation of chromosome segregation (GO:0051985)2.61173339
144nucleus localization (GO:0051647)2.60982028
145positive regulation of dendrite morphogenesis (GO:0050775)2.59855382
146regulation of synaptic transmission, glutamatergic (GO:0051966)2.58985771
147somatic diversification of immune receptors via somatic mutation (GO:0002566)2.58959983
148somatic hypermutation of immunoglobulin genes (GO:0016446)2.58959983
149regulation of helicase activity (GO:0051095)2.58851790
150cerebellum development (GO:0021549)2.58685252
151IMP biosynthetic process (GO:0006188)2.57870294
152neuron projection extension (GO:1990138)2.57626932
153regulation of mitotic spindle checkpoint (GO:1903504)2.57005503
154regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.57005503
155telomere maintenance via recombination (GO:0000722)2.56824693
156regulation of respiratory system process (GO:0044065)2.56584442
157mitotic sister chromatid cohesion (GO:0007064)2.56501374
158spindle checkpoint (GO:0031577)2.56361677
159maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.54009505
160establishment of protein localization to mitochondrial membrane (GO:0090151)2.52979642
161purine nucleobase biosynthetic process (GO:0009113)2.52092065
162protein localization to chromosome, centromeric region (GO:0071459)2.51597586
163mitotic spindle checkpoint (GO:0071174)2.51007836
164mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.50902900
165resolution of meiotic recombination intermediates (GO:0000712)2.50121453
166mitotic metaphase plate congression (GO:0007080)2.49884220
167negative regulation of DNA recombination (GO:0045910)2.48633250
168negative regulation of translation, ncRNA-mediated (GO:0040033)2.48252819
169regulation of translation, ncRNA-mediated (GO:0045974)2.48252819
170negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.48252819
171regulation of mitochondrial translation (GO:0070129)2.42223938
172DNA strand renaturation (GO:0000733)2.41343543
173postreplication repair (GO:0006301)2.41321498
174mitotic spindle assembly checkpoint (GO:0007094)2.41000861
175translesion synthesis (GO:0019985)2.38915695
176regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.38787550
177regulation of mitotic metaphase/anaphase transition (GO:0030071)2.38787550
178spliceosomal snRNP assembly (GO:0000387)2.38002987
179negative regulation of RNA splicing (GO:0033119)2.37933256
180negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.37861037
181spindle assembly checkpoint (GO:0071173)2.37672126
182regulation of sister chromatid segregation (GO:0033045)2.37292068
183regulation of mitotic sister chromatid separation (GO:0010965)2.37292068
184regulation of mitotic sister chromatid segregation (GO:0033047)2.37292068
185termination of RNA polymerase II transcription (GO:0006369)2.36436002
186nucleobase biosynthetic process (GO:0046112)2.34541771
187chaperone-mediated protein transport (GO:0072321)2.33378645
188regulation of chromosome segregation (GO:0051983)2.33282632
189regulation of centrosome cycle (GO:0046605)2.33013335
190chromatin assembly (GO:0031497)2.31567549
191IMP metabolic process (GO:0046040)2.31410950
192metaphase plate congression (GO:0051310)2.29204724
193regulation of nuclear cell cycle DNA replication (GO:0033262)2.28987473
194negative regulation of mRNA processing (GO:0050686)2.28041888
195microtubule depolymerization (GO:0007019)2.27943510

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.12739249
2EZH2_22144423_ChIP-Seq_EOC_Human6.08179546
3GBX2_23144817_ChIP-Seq_PC3_Human3.55455139
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.35852715
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.21705064
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07946257
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02674090
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.94642884
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75792617
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75792617
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.75032325
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.73827417
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.67913672
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.67358845
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.64034416
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62530185
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58333745
18* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57511170
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51350899
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49911668
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.42718813
22* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35699762
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.31535819
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.31093846
25REST_21632747_ChIP-Seq_MESCs_Mouse2.26051184
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25123285
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.22804184
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.22636082
29EST1_17652178_ChIP-ChIP_JURKAT_Human2.18366762
30* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14659498
31SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12929772
32POU5F1_16153702_ChIP-ChIP_HESCs_Human2.12257527
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.11895616
34RBPJ_22232070_ChIP-Seq_NCS_Mouse2.09690435
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.08294124
36* RARB_27405468_Chip-Seq_BRAIN_Mouse2.05364830
37GABP_17652178_ChIP-ChIP_JURKAT_Human2.05197150
38CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00888087
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.98623366
40ZNF274_21170338_ChIP-Seq_K562_Hela1.92983057
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.91297796
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89036171
43DROSHA_22980978_ChIP-Seq_HELA_Human1.88074315
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84013784
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.83511708
46AR_21909140_ChIP-Seq_LNCAP_Human1.82729112
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.82499062
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81103851
49SOX2_16153702_ChIP-ChIP_HESCs_Human1.76761375
50TAF15_26573619_Chip-Seq_HEK293_Human1.76109513
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.75143567
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.73235531
53AR_21572438_ChIP-Seq_LNCaP_Human1.73044718
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.71321821
55FUS_26573619_Chip-Seq_HEK293_Human1.68756907
56ELK1_19687146_ChIP-ChIP_HELA_Human1.68214572
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.66993926
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65081905
59IGF1R_20145208_ChIP-Seq_DFB_Human1.64435262
60RNF2_27304074_Chip-Seq_NSC_Mouse1.64096860
61MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63178125
62MYC_18940864_ChIP-ChIP_HL60_Human1.61544588
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61479571
64SMAD4_21799915_ChIP-Seq_A2780_Human1.60307352
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59929294
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59227185
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57331463
68MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56002782
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50918583
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.50552017
71NANOG_16153702_ChIP-ChIP_HESCs_Human1.50097826
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49420153
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48125482
74P300_19829295_ChIP-Seq_ESCs_Human1.47340021
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.46725549
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.46010331
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44855846
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42810566
79* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42287247
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.41922621
81TTF2_22483619_ChIP-Seq_HELA_Human1.41148934
82TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.38374443
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37435953
84SOX2_21211035_ChIP-Seq_LN229_Gbm1.36197545
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36131488
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34319387
87THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34087018
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33654448
89RING1B_27294783_Chip-Seq_NPCs_Mouse1.32802720
90VDR_22108803_ChIP-Seq_LS180_Human1.32625862
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31175044
92PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30408088
93MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28363329
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27857569
95* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26972334
96EP300_21415370_ChIP-Seq_HL-1_Mouse1.26278892
97XRN2_22483619_ChIP-Seq_HELA_Human1.26142449
98ERG_21242973_ChIP-ChIP_JURKAT_Human1.24621151
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23513132
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23422929
101JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23029735
102MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21556599
103AR_19668381_ChIP-Seq_PC3_Human1.21201063
104MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20983903
105NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20882266
106NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20569343
107EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19451504
108AR_25329375_ChIP-Seq_VCAP_Human1.18759040
109STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18105357
110IRF1_19129219_ChIP-ChIP_H3396_Human1.17499959
111YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16214458
112PIAS1_25552417_ChIP-Seq_VCAP_Human1.16026782
113ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14802122
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.14729504
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13383787
116TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13383787
117STAT3_23295773_ChIP-Seq_U87_Human1.12930685
118ARNT_22903824_ChIP-Seq_MCF-7_Human1.12686402
119GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12621890
120FOXP3_21729870_ChIP-Seq_TREG_Human1.10343516
121E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09992590
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09706543
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09397388
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09091740
125FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08039376
126WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07961565
127SOX9_26525672_Chip-Seq_HEART_Mouse1.07899878
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07640513
129* TCF4_23295773_ChIP-Seq_U87_Human1.07512179
130ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07223632
131VDR_23849224_ChIP-Seq_CD4+_Human1.05045254
132ISL1_27105846_Chip-Seq_CPCs_Mouse1.04863211
133P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04625065
134NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04412622
135HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04123135
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03775268
137GATA1_26923725_Chip-Seq_HPCs_Mouse1.02314927
138EWS_26573619_Chip-Seq_HEK293_Human1.01588811
139RUNX2_22187159_ChIP-Seq_PCA_Human1.01435920
140MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01199590
141POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00776765
142HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00512418
143JUN_21703547_ChIP-Seq_K562_Human0.99545126
144MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99101263
145AHR_22903824_ChIP-Seq_MCF-7_Human0.98833226
146SMAD3_21741376_ChIP-Seq_ESCs_Human0.98831323
147TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98458217
148TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97604523
149MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97291367
150* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95645954
151ER_23166858_ChIP-Seq_MCF-7_Human0.95539263
152FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95404857
153RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94558169
154FLI1_27457419_Chip-Seq_LIVER_Mouse0.94214440
155SMAD_19615063_ChIP-ChIP_OVARY_Human0.94091374
156BCAT_22108803_ChIP-Seq_LS180_Human0.93758537
157DCP1A_22483619_ChIP-Seq_HELA_Human0.92653318
158ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89468559
159PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88026396
160NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.87825013
161GABP_19822575_ChIP-Seq_HepG2_Human0.87505221
162TBX3_20139965_ChIP-Seq_MESCs_Mouse0.86549804
163TBX3_20139965_ChIP-Seq_ESCs_Mouse0.86538867
164GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86333780
165* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.85985707
166POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84893835
167CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84881974

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.69985235
2MP0003880_abnormal_central_pattern3.70689450
3MP0003635_abnormal_synaptic_transmissio3.21449802
4MP0006292_abnormal_olfactory_placode3.02968889
5MP0002063_abnormal_learning/memory/cond2.71702170
6MP0004270_analgesia2.64799296
7MP0003890_abnormal_embryonic-extraembry2.59665375
8MP0010094_abnormal_chromosome_stability2.54662171
9MP0009745_abnormal_behavioral_response2.48261337
10MP0003693_abnormal_embryo_hatching2.37469202
11MP0005423_abnormal_somatic_nervous2.31757761
12MP0001968_abnormal_touch/_nociception2.27748493
13MP0008058_abnormal_DNA_repair2.26047022
14MP0003122_maternal_imprinting2.21808698
15MP0000778_abnormal_nervous_system2.21362024
16MP0001293_anophthalmia2.19532712
17MP0002572_abnormal_emotion/affect_behav2.18317556
18MP0000751_myopathy2.17979646
19MP0002064_seizures2.04650956
20MP0009046_muscle_twitch1.97556535
21MP0009780_abnormal_chondrocyte_physiolo1.95681409
22MP0004957_abnormal_blastocyst_morpholog1.95350072
23MP0008057_abnormal_DNA_replication1.95283807
24MP0004215_abnormal_myocardial_fiber1.93731083
25MP0001486_abnormal_startle_reflex1.93539985
26MP0003787_abnormal_imprinting1.90853958
27MP0000566_synostosis1.89738212
28MP0003937_abnormal_limbs/digits/tail_de1.89033112
29MP0003111_abnormal_nucleus_morphology1.87240059
30MP0002734_abnormal_mechanical_nocicepti1.87065785
31MP0004145_abnormal_muscle_electrophysio1.84297512
32MP0004084_abnormal_cardiac_muscle1.84250928
33MP0002184_abnormal_innervation1.83596528
34MP0001440_abnormal_grooming_behavior1.80488255
35MP0002736_abnormal_nociception_after1.75783455
36MP0003567_abnormal_fetal_cardiomyocyte1.75749093
37MP0003136_yellow_coat_color1.74497176
38MP0002272_abnormal_nervous_system1.74319633
39MP0002938_white_spotting1.70827139
40MP0008932_abnormal_embryonic_tissue1.70751484
41MP0010030_abnormal_orbit_morphology1.66604302
42MP0002102_abnormal_ear_morphology1.64154838
43MP0003077_abnormal_cell_cycle1.61387691
44MP0002837_dystrophic_cardiac_calcinosis1.60705893
45MP0003879_abnormal_hair_cell1.59049179
46MP0002557_abnormal_social/conspecific_i1.57651629
47MP0003121_genomic_imprinting1.56166804
48MP0002697_abnormal_eye_size1.54745327
49MP0002233_abnormal_nose_morphology1.54611594
50MP0008877_abnormal_DNA_methylation1.53494952
51MP0002067_abnormal_sensory_capabilities1.53094011
52MP0006276_abnormal_autonomic_nervous1.53081995
53MP0002735_abnormal_chemical_nociception1.52582609
54MP0001188_hyperpigmentation1.51550002
55MP0004811_abnormal_neuron_physiology1.47208026
56MP0004133_heterotaxia1.44759061
57MP0001286_abnormal_eye_development1.42819047
58MP0003941_abnormal_skin_development1.40481924
59MP0005187_abnormal_penis_morphology1.37698949
60MP0002733_abnormal_thermal_nociception1.36734741
61MP0004036_abnormal_muscle_relaxation1.36715225
62MP0004085_abnormal_heartbeat1.36406906
63MP0008995_early_reproductive_senescence1.34548652
64MP0000631_abnormal_neuroendocrine_gland1.33318929
65MP0004858_abnormal_nervous_system1.33274405
66MP0000537_abnormal_urethra_morphology1.32692495
67MP0009672_abnormal_birth_weight1.30805883
68MP0003137_abnormal_impulse_conducting1.30790256
69MP0000955_abnormal_spinal_cord1.30551472
70MP0003718_maternal_effect1.30429747
71MP0005386_behavior/neurological_phenoty1.30113682
72MP0004924_abnormal_behavior1.30113682
73MP0009697_abnormal_copulation1.27675286
74MP0009379_abnormal_foot_pigmentation1.26504272
75MP0002882_abnormal_neuron_morphology1.25548480
76MP0004885_abnormal_endolymph1.25067957
77MP0000569_abnormal_digit_pigmentation1.23931624
78MP0008569_lethality_at_weaning1.23325844
79MP0001970_abnormal_pain_threshold1.20652115
80MP0002084_abnormal_developmental_patter1.20407298
81MP0003938_abnormal_ear_development1.18456489
82MP0002152_abnormal_brain_morphology1.17820641
83MP0005620_abnormal_muscle_contractility1.16093469
84MP0002085_abnormal_embryonic_tissue1.14975373
85MP0001984_abnormal_olfaction1.14320742
86MP0003315_abnormal_perineum_morphology1.13280305
87MP0004484_altered_response_of1.13256695
88MP0004233_abnormal_muscle_weight1.12270174
89MP0002751_abnormal_autonomic_nervous1.10880432
90MP0002972_abnormal_cardiac_muscle1.09333769
91MP0005623_abnormal_meninges_morphology1.07790679
92MP0001299_abnormal_eye_distance/1.06543869
93MP0003119_abnormal_digestive_system1.06103460
94MP0002111_abnormal_tail_morphology1.04876366
95MP0001485_abnormal_pinna_reflex1.04559439
96MP0006138_congestive_heart_failure1.04193246
97MP0002066_abnormal_motor_capabilities/c1.04191859
98MP0003123_paternal_imprinting1.03992585
99MP0002234_abnormal_pharynx_morphology1.03653493
100MP0003755_abnormal_palate_morphology1.02191801
101MP0002653_abnormal_ependyma_morphology1.00783896
102MP0003861_abnormal_nervous_system1.00123957
103MP0005377_hearing/vestibular/ear_phenot0.99436527
104MP0003878_abnormal_ear_physiology0.99436527
105MP0004742_abnormal_vestibular_system0.99153016
106MP0004197_abnormal_fetal_growth/weight/0.98415205
107MP0002160_abnormal_reproductive_system0.98414349
108MP0005391_vision/eye_phenotype0.97538142
109MP0005253_abnormal_eye_physiology0.96079168
110MP0005499_abnormal_olfactory_system0.96067157
111MP0005394_taste/olfaction_phenotype0.96067157
112MP0001672_abnormal_embryogenesis/_devel0.95902461
113MP0005380_embryogenesis_phenotype0.95902461
114MP0009703_decreased_birth_body0.95703300
115MP0001730_embryonic_growth_arrest0.95699275
116MP0002638_abnormal_pupillary_reflex0.95263788
117MP0005646_abnormal_pituitary_gland0.95140723
118MP0001529_abnormal_vocalization0.94998385
119MP0002092_abnormal_eye_morphology0.94481138
120MP0000428_abnormal_craniofacial_morphol0.94261315
121MP0001697_abnormal_embryo_size0.94002918
122MP0001501_abnormal_sleep_pattern0.93969071
123MP0005551_abnormal_eye_electrophysiolog0.92690477
124MP0002210_abnormal_sex_determination0.91993301
125MP0003221_abnormal_cardiomyocyte_apopto0.88364696
126MP0005645_abnormal_hypothalamus_physiol0.88252638
127MP0003115_abnormal_respiratory_system0.87184816
128MP0008007_abnormal_cellular_replicative0.87063661
129MP0005248_abnormal_Harderian_gland0.86804453
130MP0003942_abnormal_urinary_system0.86077925
131MP0002909_abnormal_adrenal_gland0.86016738
132MP0003329_amyloid_beta_deposits0.85711476
133MP0006072_abnormal_retinal_apoptosis0.84775608
134MP0002127_abnormal_cardiovascular_syste0.84439748
135MP0002081_perinatal_lethality0.83118097
136MP0003984_embryonic_growth_retardation0.82837910
137MP0000350_abnormal_cell_proliferation0.82188472
138MP0005330_cardiomyopathy0.81930835
139MP0002088_abnormal_embryonic_growth/wei0.81136225
140MP0003935_abnormal_craniofacial_develop0.80252743
141MP0001145_abnormal_male_reproductive0.80216320
142MP0001346_abnormal_lacrimal_gland0.80094551
143MP0003385_abnormal_body_wall0.80082464
144MP0002249_abnormal_larynx_morphology0.79306127
145MP0002752_abnormal_somatic_nervous0.77826584
146MP0002822_catalepsy0.76535947
147MP0008789_abnormal_olfactory_epithelium0.75511046
148MP0004147_increased_porphyrin_level0.75203800
149MP0001963_abnormal_hearing_physiology0.74796582
150MP0000049_abnormal_middle_ear0.73940981
151MP0005409_darkened_coat_color0.73546111
152MP0000749_muscle_degeneration0.73302440
153MP0002106_abnormal_muscle_physiology0.72834546
154MP0004087_abnormal_muscle_fiber0.72378744
155MP0001905_abnormal_dopamine_level0.70771965
156MP0001177_atelectasis0.70209886

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.85197736
2Focal seizures (HP:0007359)3.96858961
3Myokymia (HP:0002411)3.89066873
4Visual hallucinations (HP:0002367)3.77294669
5Epileptic encephalopathy (HP:0200134)3.69837041
6Colon cancer (HP:0003003)3.37184451
7Abnormality of the labia minora (HP:0012880)3.32770250
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.26516792
9Septo-optic dysplasia (HP:0100842)3.23198847
10Chromsome breakage (HP:0040012)3.22177517
11Hyperventilation (HP:0002883)3.20280145
12Broad-based gait (HP:0002136)3.09392050
13Ankle clonus (HP:0011448)3.03852195
14Atonic seizures (HP:0010819)2.90386815
15Poor eye contact (HP:0000817)2.88511921
16Generalized tonic-clonic seizures (HP:0002069)2.88157807
17Progressive inability to walk (HP:0002505)2.86583364
18Absence seizures (HP:0002121)2.76232633
19Meckel diverticulum (HP:0002245)2.75299358
20Progressive cerebellar ataxia (HP:0002073)2.74322331
21Sudden death (HP:0001699)2.73482932
22Cortical dysplasia (HP:0002539)2.71313141
23Febrile seizures (HP:0002373)2.71259219
24Excessive salivation (HP:0003781)2.65329510
25Drooling (HP:0002307)2.65329510
26Mutism (HP:0002300)2.61415362
27Abnormality of the ileum (HP:0001549)2.61085313
28Amyotrophic lateral sclerosis (HP:0007354)2.60390636
29Amblyopia (HP:0000646)2.56736181
30Aplasia/Hypoplasia of the uvula (HP:0010293)2.51699082
31Birth length less than 3rd percentile (HP:0003561)2.50942957
32Inability to walk (HP:0002540)2.44158438
33Abnormality of chromosome stability (HP:0003220)2.43300849
34Abnormal lung lobation (HP:0002101)2.41921370
35Gonadal dysgenesis (HP:0000133)2.39480035
36Reticulocytopenia (HP:0001896)2.38430116
37Primary atrial arrhythmia (HP:0001692)2.38073487
38Dialeptic seizures (HP:0011146)2.37037438
39Papilledema (HP:0001085)2.35978814
40Intestinal atresia (HP:0011100)2.35853067
41Megalencephaly (HP:0001355)2.35194244
42Atrial fibrillation (HP:0005110)2.35179413
43Volvulus (HP:0002580)2.34548265
44Testicular neoplasm (HP:0010788)2.31343494
45Nephroblastoma (Wilms tumor) (HP:0002667)2.29323220
46Abnormal social behavior (HP:0012433)2.28152546
47Impaired social interactions (HP:0000735)2.28152546
48Hypoplastic left heart (HP:0004383)2.27927443
49Impaired vibration sensation in the lower limbs (HP:0002166)2.27713737
50Anophthalmia (HP:0000528)2.27473489
51Supraventricular tachycardia (HP:0004755)2.26142822
52Hyperglycinemia (HP:0002154)2.25722359
53Depression (HP:0000716)2.24756571
54Aplasia/Hypoplasia of the sternum (HP:0006714)2.23857562
55Shoulder girdle muscle weakness (HP:0003547)2.23025006
56Supraventricular arrhythmia (HP:0005115)2.22571566
57Rimmed vacuoles (HP:0003805)2.22115335
58Embryonal renal neoplasm (HP:0011794)2.18805421
59Esophageal atresia (HP:0002032)2.18618464
60Limb dystonia (HP:0002451)2.18280155
61Optic nerve hypoplasia (HP:0000609)2.15861130
62Urinary urgency (HP:0000012)2.15692381
63Triphalangeal thumb (HP:0001199)2.15249587
64Protruding tongue (HP:0010808)2.13883358
65Aplasia/Hypoplasia of the brainstem (HP:0007362)2.13431097
66Hypoplasia of the brainstem (HP:0002365)2.13431097
67Absent septum pellucidum (HP:0001331)2.13340382
68Inappropriate behavior (HP:0000719)2.11022724
69Exercise-induced myalgia (HP:0003738)2.10981236
70Urinary bladder sphincter dysfunction (HP:0002839)2.09995137
71Truncal ataxia (HP:0002078)2.07760141
72Insomnia (HP:0100785)2.06541298
73Calf muscle hypertrophy (HP:0008981)2.05530532
74Prolonged QT interval (HP:0001657)2.04188525
75Abnormality of the septum pellucidum (HP:0007375)2.03429377
76Germ cell neoplasia (HP:0100728)2.02598579
77Asymmetry of the thorax (HP:0001555)2.02476985
78Anxiety (HP:0000739)2.02044751
79Muscle hypertrophy of the lower extremities (HP:0008968)2.01964172
80Lissencephaly (HP:0001339)2.01700466
81Abnormality of the lower motor neuron (HP:0002366)2.01455839
82Absent radius (HP:0003974)2.01346255
83Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.00697595
84Termporal pattern (HP:0011008)1.99091845
85Insidious onset (HP:0003587)1.99091845
86Pachygyria (HP:0001302)1.97676336
87Lower limb amyotrophy (HP:0007210)1.97360531
88Ectopic kidney (HP:0000086)1.96534206
89Abnormality of the duodenum (HP:0002246)1.95746508
90Pheochromocytoma (HP:0002666)1.95477009
91Abnormal EKG (HP:0003115)1.94571443
92Stereotypic behavior (HP:0000733)1.94475398
93Abnormality of the calf musculature (HP:0001430)1.93864825
94Gastrointestinal atresia (HP:0002589)1.93064213
95Absent speech (HP:0001344)1.92938147
96Morphological abnormality of the middle ear (HP:0008609)1.92930192
97Hypoventilation (HP:0002791)1.92907684
98Hepatoblastoma (HP:0002884)1.92638190
99Absent forearm bone (HP:0003953)1.92553505
100Aplasia involving forearm bones (HP:0009822)1.92553505
101Male infertility (HP:0003251)1.92207267
102Hemiparesis (HP:0001269)1.91967239
103Epileptiform EEG discharges (HP:0011182)1.91239921
104Maternal diabetes (HP:0009800)1.91224013
105Dysdiadochokinesis (HP:0002075)1.90655574
106Gaze-evoked nystagmus (HP:0000640)1.90437467
107Lower limb muscle weakness (HP:0007340)1.90122432
108Pointed chin (HP:0000307)1.90017594
109Bifid tongue (HP:0010297)1.89823396
110Increased nuchal translucency (HP:0010880)1.89426878
111Supernumerary spleens (HP:0009799)1.89245280
112Abnormality of the preputium (HP:0100587)1.89073217
113Small intestinal stenosis (HP:0012848)1.88104229
114Duodenal stenosis (HP:0100867)1.88104229
115Vaginal atresia (HP:0000148)1.87861313
116Agitation (HP:0000713)1.87085482
117Ventricular fibrillation (HP:0001663)1.86336106
118Medulloblastoma (HP:0002885)1.85926354
119Genital tract atresia (HP:0001827)1.85505813
120Bilateral microphthalmos (HP:0007633)1.85121184
121Renal duplication (HP:0000075)1.84031311
122Action tremor (HP:0002345)1.82920653
123EEG with generalized epileptiform discharges (HP:0011198)1.82803793
124High anterior hairline (HP:0009890)1.82390094
125Abnormal number of incisors (HP:0011064)1.82330511
126Acute necrotizing encephalopathy (HP:0006965)1.82029515
127Syncope (HP:0001279)1.80853731
128Abnormality of the carotid arteries (HP:0005344)1.80832317
129Increased hepatocellular lipid droplets (HP:0006565)1.80740881
130Acute encephalopathy (HP:0006846)1.80173721
131Cutaneous finger syndactyly (HP:0010554)1.78275949
132Renal hypoplasia (HP:0000089)1.77630699
133Complete atrioventricular canal defect (HP:0001674)1.77430218
134Rib fusion (HP:0000902)1.76263950
135Genetic anticipation (HP:0003743)1.75281206
136Sacral dimple (HP:0000960)1.75142525
137Patellar aplasia (HP:0006443)1.73292344
138Hypsarrhythmia (HP:0002521)1.73236887
139Atrioventricular canal defect (HP:0006695)1.72358402
140Male pseudohermaphroditism (HP:0000037)1.72324909
141Gait imbalance (HP:0002141)1.71801177
142Abnormality of cochlea (HP:0000375)1.71380135
143Duplication of thumb phalanx (HP:0009942)1.70663163
144Hemivertebrae (HP:0002937)1.70580709
145Hyperthyroidism (HP:0000836)1.70029614
146Horseshoe kidney (HP:0000085)1.68592803
147Pendular nystagmus (HP:0012043)1.68529419
148Spastic gait (HP:0002064)1.68159375
149True hermaphroditism (HP:0010459)1.67829944
150Hypoplastic heart (HP:0001961)1.67622559
151Cutaneous syndactyly (HP:0012725)1.66994723
152Facial cleft (HP:0002006)1.66445970
153Oligodactyly (hands) (HP:0001180)1.66355030
154Preaxial hand polydactyly (HP:0001177)1.66235659
155Gastroesophageal reflux (HP:0002020)1.65730413
156Absent eyebrow (HP:0002223)1.65587604
157Autism (HP:0000717)1.65417163
158Hyperglycinuria (HP:0003108)1.64613963
159Supranuclear gaze palsy (HP:0000605)1.64605183
160Aqueductal stenosis (HP:0002410)1.64255735
161Sloping forehead (HP:0000340)1.62890165
162Congenital primary aphakia (HP:0007707)1.61874586
163Nephronophthisis (HP:0000090)1.61831037
164Lipid accumulation in hepatocytes (HP:0006561)1.61694542
165Morphological abnormality of the inner ear (HP:0011390)1.60616343
166Medial flaring of the eyebrow (HP:0010747)1.60398166
167Myelomeningocele (HP:0002475)1.60185964
168Pancreatic fibrosis (HP:0100732)1.59138783
169Aplasia/Hypoplasia of the patella (HP:0006498)1.58920830
170Sporadic (HP:0003745)1.58744821
171Exotropia (HP:0000577)1.58139650
172Neuroendocrine neoplasm (HP:0100634)1.57248497
173Subaortic stenosis (HP:0001682)1.56488039
174Abnormality of the left ventricular outflow tract (HP:0011103)1.56488039
175Torticollis (HP:0000473)1.56321495
176Fetal akinesia sequence (HP:0001989)1.55611701
177Micropenis (HP:0000054)1.55519572
178Abnormality of glycine metabolism (HP:0010895)1.55033548
179Abnormality of serine family amino acid metabolism (HP:0010894)1.55033548
180Abnormal mitochondria in muscle tissue (HP:0008316)1.54212870
181Preaxial foot polydactyly (HP:0001841)1.53553846
182Pancreatic islet-cell hyperplasia (HP:0004510)1.50967043
183Broad foot (HP:0001769)1.50612278
184Pancreatic cysts (HP:0001737)1.49909337
185Dandy-Walker malformation (HP:0001305)1.49845340
186Hypoplastic female external genitalia (HP:0012815)1.49812113
187Midline defect of the nose (HP:0004122)1.49361756
188Neoplasm of the colon (HP:0100273)1.49197650
189Progressive macrocephaly (HP:0004481)1.48994233
190Nephrogenic diabetes insipidus (HP:0009806)1.47986222
191Oligodactyly (HP:0012165)1.47502623
192Embryonal neoplasm (HP:0002898)1.47075456
193Sclerocornea (HP:0000647)1.46708140
194Anencephaly (HP:0002323)1.46560342
195Scrotal hypoplasia (HP:0000046)1.46238279
196Abnormality of abdominal situs (HP:0011620)1.45699375
197Abdominal situs inversus (HP:0003363)1.45699375

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.27121703
2CDC73.79382622
3MAP3K43.46647998
4NTRK33.23093430
5MAP2K72.88024365
6EPHA42.84599373
7SRPK12.76817548
8MINK12.64776896
9BUB12.64090470
10CASK2.47438214
11TTK2.36085267
12MAP3K92.34391646
13MAPK132.33379293
14MKNK12.32668794
15PLK42.31539192
16DAPK22.27640118
17NTRK22.26090094
18MAP2K42.17778235
19ZAK2.08745686
20WEE11.98624634
21TAF11.87539459
22TSSK61.86844115
23KSR11.86088222
24MAP3K121.79058784
25PLK21.74045168
26PHKG21.70310447
27PHKG11.70310447
28TYRO31.69913112
29VRK21.68417711
30ERBB31.57949126
31MYLK1.55164088
32VRK11.52539602
33PBK1.52015318
34TNIK1.50214226
35PRPF4B1.46365173
36CCNB11.44936897
37DAPK11.44000456
38DYRK31.43222370
39BRSK21.39646496
40STK161.39489413
41OBSCN1.38737767
42PLK11.38616769
43SIK21.37372493
44PAK61.35735307
45TRIM281.32908253
46NUAK11.30558008
47DYRK21.29761706
48PRKD31.24497056
49CHEK21.21588969
50CDK51.20457485
51MAP3K61.19026623
52BMPR1B1.17440137
53ATR1.14569784
54PAK31.12462697
55NEK21.12171477
56EPHB21.11918557
57CAMKK11.11897698
58UHMK11.10713460
59MAP4K21.09171163
60CSNK1G11.08900792
61LATS21.08580237
62LATS11.07343206
63MAP3K101.04448916
64STK38L1.02382860
65KSR21.01728773
66LMTK21.01384104
67STK240.97763950
68RPS6KA40.94975225
69PTK2B0.93702358
70PRKCG0.91118193
71PASK0.90558001
72ATM0.89991408
73DYRK1A0.88644926
74WNK40.88342558
75STK390.87737593
76CAMK2A0.86416868
77CAMK1G0.85184191
78PNCK0.84648889
79NME10.83708967
80AURKB0.83264522
81CDK180.83043007
82LIMK10.82918491
83CSNK1G20.82603099
84CDC42BPA0.80925974
85RET0.80555454
86CDK140.78703565
87CSNK1E0.78644273
88CDK150.78015026
89DMPK0.77531876
90MAPK120.77288181
91CHEK10.74172184
92CDK30.74077623
93GRK50.72211342
94CDK190.71056275
95NTRK10.69527334
96WNK30.69192316
97CDK11A0.67391579
98ILK0.63786443
99SIK30.63393400
100CDK10.61355488
101FGFR20.60855507
102STK30.60844410
103CDK70.60687608
104CAMK10.60623361
105ALK0.59935629
106PRKDC0.59348194
107RAF10.59316752
108CAMKK20.58985604
109CAMK1D0.58210929
110CDK20.57563232
111GRK10.57531126
112BRD40.57052240
113RPS6KA20.57033113
114PDGFRA0.56834455
115PINK10.56208560
116SGK2230.53821046
117SGK4940.53821046
118PKN20.53658273
119STK110.52908277
120ROCK10.52499528
121CAMK2B0.52323937
122SGK20.52122085
123EIF2AK10.51143498
124EIF2AK20.50573489
125MARK20.50520221
126RIPK40.49443514
127EIF2AK30.49103117
128NEK10.48577528
129AURKA0.47932514
130CSNK2A20.47653858
131PRKCE0.46656069
132BCR0.45775465
133SGK10.45768989
134INSRR0.45435048
135CAMK40.44726574
136PRKCZ0.44723482
137FGFR10.44672878
138DAPK30.43526675
139CSNK2A10.43522379
140ERBB40.42466041
141FES0.41976636
142ADRBK10.41968531
143PDK30.41826860
144PDK40.41826860
145ADRBK20.41512306
146MAP3K20.41376043
147BRSK10.41034126
148MKNK20.39140322
149PKN10.38897355
150OXSR10.38385272
151FRK0.38220209
152CSNK1G30.37722544
153PIK3CA0.37440250
154RPS6KA50.36283381
155YES10.35875611
156CSNK1A1L0.35470356
157RPS6KA30.34811584
158CAMK2D0.34779497
159AKT30.34460670
160PLK30.34172596
161MUSK0.33513824

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.29459647
2Mismatch repair_Homo sapiens_hsa034303.18124900
3Nicotine addiction_Homo sapiens_hsa050333.12764348
4Non-homologous end-joining_Homo sapiens_hsa034502.68552429
5Circadian entrainment_Homo sapiens_hsa047132.58275771
6Long-term potentiation_Homo sapiens_hsa047202.55896524
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.48476965
8Homologous recombination_Homo sapiens_hsa034402.43841617
9Spliceosome_Homo sapiens_hsa030402.29615290
10Ribosome_Homo sapiens_hsa030102.28031552
11Glutamatergic synapse_Homo sapiens_hsa047242.26331314
12Olfactory transduction_Homo sapiens_hsa047402.24502693
13Fanconi anemia pathway_Homo sapiens_hsa034602.24243629
14Dopaminergic synapse_Homo sapiens_hsa047282.18911393
15Morphine addiction_Homo sapiens_hsa050322.15432394
16Amphetamine addiction_Homo sapiens_hsa050312.14760442
17Synaptic vesicle cycle_Homo sapiens_hsa047212.14609887
18GABAergic synapse_Homo sapiens_hsa047272.14036278
19RNA transport_Homo sapiens_hsa030132.08368606
20Protein export_Homo sapiens_hsa030602.07289571
21RNA polymerase_Homo sapiens_hsa030202.02735479
22Base excision repair_Homo sapiens_hsa034102.01687870
23Cardiac muscle contraction_Homo sapiens_hsa042602.01581726
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00756273
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.99028975
26Renin secretion_Homo sapiens_hsa049241.96475177
27Cell cycle_Homo sapiens_hsa041101.93082104
28Nucleotide excision repair_Homo sapiens_hsa034201.87038206
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84623426
30Oxytocin signaling pathway_Homo sapiens_hsa049211.81086530
31Axon guidance_Homo sapiens_hsa043601.78608211
32Cholinergic synapse_Homo sapiens_hsa047251.78598921
33Salivary secretion_Homo sapiens_hsa049701.77520153
34Basal transcription factors_Homo sapiens_hsa030221.77062640
35Long-term depression_Homo sapiens_hsa047301.74949809
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74320013
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72132341
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.68559836
39One carbon pool by folate_Homo sapiens_hsa006701.68180658
40Steroid biosynthesis_Homo sapiens_hsa001001.67444897
41Gastric acid secretion_Homo sapiens_hsa049711.65846968
42Insulin secretion_Homo sapiens_hsa049111.63721229
43Gap junction_Homo sapiens_hsa045401.63005481
44RNA degradation_Homo sapiens_hsa030181.59787106
45Serotonergic synapse_Homo sapiens_hsa047261.57760535
46Dilated cardiomyopathy_Homo sapiens_hsa054141.57669323
47Proteasome_Homo sapiens_hsa030501.57212229
48Calcium signaling pathway_Homo sapiens_hsa040201.55818315
49Taste transduction_Homo sapiens_hsa047421.54320679
50Propanoate metabolism_Homo sapiens_hsa006401.50167903
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49956555
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.46607674
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46146367
54GnRH signaling pathway_Homo sapiens_hsa049121.44603023
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.40160593
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37352214
57Phototransduction_Homo sapiens_hsa047441.33311979
58Oocyte meiosis_Homo sapiens_hsa041141.32583625
59cAMP signaling pathway_Homo sapiens_hsa040241.29938009
60Cocaine addiction_Homo sapiens_hsa050301.29231344
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.25961363
62Melanogenesis_Homo sapiens_hsa049161.22781647
63Glioma_Homo sapiens_hsa052141.22146815
64Pyrimidine metabolism_Homo sapiens_hsa002401.19827033
65Pyruvate metabolism_Homo sapiens_hsa006201.17978623
66Selenocompound metabolism_Homo sapiens_hsa004501.17084024
67Estrogen signaling pathway_Homo sapiens_hsa049151.16473122
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16457804
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14847999
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13810553
71Vascular smooth muscle contraction_Homo sapiens_hsa042701.10583283
72Parkinsons disease_Homo sapiens_hsa050121.08599172
73Alzheimers disease_Homo sapiens_hsa050101.07918459
74Purine metabolism_Homo sapiens_hsa002301.06399430
75ErbB signaling pathway_Homo sapiens_hsa040121.06255474
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04699872
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.04102665
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03630566
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03473958
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03330021
81Vitamin B6 metabolism_Homo sapiens_hsa007501.02730538
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98786031
83Butanoate metabolism_Homo sapiens_hsa006500.97498162
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96525296
85Biosynthesis of amino acids_Homo sapiens_hsa012300.96071385
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93638651
87Type II diabetes mellitus_Homo sapiens_hsa049300.92821188
88Endometrial cancer_Homo sapiens_hsa052130.91617856
89Folate biosynthesis_Homo sapiens_hsa007900.91510849
90Wnt signaling pathway_Homo sapiens_hsa043100.90871422
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90131172
92Huntingtons disease_Homo sapiens_hsa050160.88672358
93Oxidative phosphorylation_Homo sapiens_hsa001900.88481542
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87358021
95Fatty acid elongation_Homo sapiens_hsa000620.85085779
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80192664
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.77707093
98Alcoholism_Homo sapiens_hsa050340.77694252
99Colorectal cancer_Homo sapiens_hsa052100.77440609
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76257179
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73864655
102Glucagon signaling pathway_Homo sapiens_hsa049220.73277910
103Fatty acid metabolism_Homo sapiens_hsa012120.72435126
104TGF-beta signaling pathway_Homo sapiens_hsa043500.72415762
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72139330
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71976218
107VEGF signaling pathway_Homo sapiens_hsa043700.71914786
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.71792815
109Dorso-ventral axis formation_Homo sapiens_hsa043200.71505201
110MAPK signaling pathway_Homo sapiens_hsa040100.70410136
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69877070
112Hedgehog signaling pathway_Homo sapiens_hsa043400.68709268
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68277627
114Thyroid hormone synthesis_Homo sapiens_hsa049180.65784551
115Carbon metabolism_Homo sapiens_hsa012000.65168046
116Tight junction_Homo sapiens_hsa045300.62915484
117Hippo signaling pathway_Homo sapiens_hsa043900.61257331
118Lysine degradation_Homo sapiens_hsa003100.60721635
119Rap1 signaling pathway_Homo sapiens_hsa040150.60196796
120Non-small cell lung cancer_Homo sapiens_hsa052230.58669704
121Arginine and proline metabolism_Homo sapiens_hsa003300.58287773
122Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57569273
123p53 signaling pathway_Homo sapiens_hsa041150.56534762
124Choline metabolism in cancer_Homo sapiens_hsa052310.56507910
125Ras signaling pathway_Homo sapiens_hsa040140.56248679
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56060458
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55822636
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.55427608
129Renal cell carcinoma_Homo sapiens_hsa052110.55021947
130Metabolic pathways_Homo sapiens_hsa011000.54791914
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54782152
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54569597
133Collecting duct acid secretion_Homo sapiens_hsa049660.54029416
134mTOR signaling pathway_Homo sapiens_hsa041500.53954330
135Insulin signaling pathway_Homo sapiens_hsa049100.53562654
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53092756
137Ovarian steroidogenesis_Homo sapiens_hsa049130.52919075
138Focal adhesion_Homo sapiens_hsa045100.52387545
139Vibrio cholerae infection_Homo sapiens_hsa051100.51867620
140Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51612398
141Central carbon metabolism in cancer_Homo sapiens_hsa052300.51221401
142mRNA surveillance pathway_Homo sapiens_hsa030150.50695151
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.49037316
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48906952
145Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48485963
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47930576
147Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47434404
148Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45783607
149Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45579981
150Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45245734
151Sulfur relay system_Homo sapiens_hsa041220.43720207
152Basal cell carcinoma_Homo sapiens_hsa052170.43238240
153Pancreatic secretion_Homo sapiens_hsa049720.43001641
154Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42488151
155Fatty acid degradation_Homo sapiens_hsa000710.42097294
156Fat digestion and absorption_Homo sapiens_hsa049750.40797837
157Viral myocarditis_Homo sapiens_hsa054160.40172189
158Arginine biosynthesis_Homo sapiens_hsa002200.39144491
159Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38803874
160Adherens junction_Homo sapiens_hsa045200.37963308
161Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37392598
162Glutathione metabolism_Homo sapiens_hsa004800.37161588
163Peroxisome_Homo sapiens_hsa041460.36897624
164Vitamin digestion and absorption_Homo sapiens_hsa049770.35841777
165Tryptophan metabolism_Homo sapiens_hsa003800.32336705
166beta-Alanine metabolism_Homo sapiens_hsa004100.30978885
167Nitrogen metabolism_Homo sapiens_hsa009100.30516221

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